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blood management

George A Dumas, Ayesha S Bryant, Justin Ibey, John A Long, Matthew G Vicinanzo, Gwendolyn L Boyd
PURPOSE: This study will determine the safety of laryngeal mask airway (LMA) compared with endotracheal tube (ETT) in patients undergoing general anesthesia for dacryocystorhinostomy (DCR) surgery. METHODS: In this retrospective cohort study, intraoperative and postoperative outcomes of patients who underwent DCR at UAB Callahan Eye Hospital using either LMA or ETT were compared. RESULTS: Over a period of 52 months, 429 patients underwent external DCR surgery...
August 8, 2017: Ophthalmic Plastic and Reconstructive Surgery
Aryane Flauzino Machado, Jéssica Kirsch Micheletti, Jaqueline Santos Silva Lopes, Franciele Marques Vanderlei, Ernesto Cesar Pinto Leal-Junior, Jayme Netto Junior, Carlos Marcelo Pastre
OBJECTIVE: The main focus of this systematic review was to determine the efficacy of phototherapy in the management of creatine kinase (CK) activity after exercise and furthermore to identify for which exercise model protocol phototherapy provides the best results. DESIGN: Meta-analysis comparing phototherapy with a control condition. SETTING: The MEDLINE, EMBASE, SPORTDiscus, PEDro, and CENTRAL databases were searched from their earliest records to October 03, 2016...
June 21, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Jeron Zerillo, Parul Agarwal, Jashvant Poeran, Nicole Zubizarreta, George Poultsides, Myron Schwartz, Stavros Memtsoudis, Madhu Mazumdar, Samuel DeMaria
BACKGROUND: Complication rates after hepatic resection can be affected by management decisions of the hospital care team and/or disparities in care. This is true in many other surgical populations, but little study has been done regarding patients undergoing hepatectomy. METHODS: Data from the claims-based national Premier Perspective database were used for 2006 to 2014. The analytical sample consisted of adults undergoing partial hepatectomy and total hepatic lobectomy with anesthesia care consisting of general anesthesia (GA) only or neuraxial and GA (n = 9442)...
June 20, 2018: Anesthesia and Analgesia
Yizhuo Yang, Zhongyu Liu, Lei Song, Hui Liu, Lian Li, Yuanguang Meng
INTRODUCTION: Retroperitoneal ectopic pregnancy (REP) is a rare type of gestation that is difficult to diagnose and treat. To date, only several published cases are available and no specific guideline has been developed to manage this disease. As the lesions are located closely to the large retroperitoneal blood vessels, surgical resection of the gestational tissue might incur risks such as associated hemorrhage, injury of blood vessels or nerves. On the other hand, the therapeutic effect of conservative treatment using methotrexate is not satisfactory...
June 9, 2018: International Journal of Surgery Case Reports
Kim Marienhagen, Frank Lehner, Jürgen Klempnauer, Hartmut Hecker, Jürgen Borlak
Post-transplant hypertension (PTH) is a common complication in cyclosporine immunosuppressed patients; however choosing the right antihypertensive medication is challenging. In a long-term observational study (≤13y) we examined different antihypertensive medications on graft/patient survival of kidney recipients with pre-existing and PTH. Altogether thirty-three co-variables were analyzed including dose and type of immunosuppressive and antihypertensive medication, co-medications, serum biochemistries and the glomerular filtration rate (GFR)...
June 19, 2018: Vascular Pharmacology
Patrick H Kee, Delia Danila
Management of patients suffering from myocardial infarction (MI) is based on the extent of coronary artery disease and myocardial scar burden. We have developed a potentially clinically-useful X-ray molecular imaging contrast agent based on gold nanoparticle (AuNPs) functionalized with collagen-binding adhesion protein 35 (CNA35) with the capabilities of achieving prolonged blood pool enhancement for vascular imaging of the coronary arteries and specific targeting of collagen within myocardial scar. At a concentration of ~ 45mg Au/ml, AuNPs maintained a stable blood pool enhancement at 142-160 HU within an hour of intravenous administration...
June 19, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Kwang-Bok Lee, Seong-Yup Jeong, Seung-Ho Kim, Dong-Gun Shim
The surgical management of distal intra-articular comminuted fracture of the tibia (pilon fracture) is difficult because complications frequently develop. The minimally invasive plate osteosynthesis technique is generally accepted for this type of fracture. In this study, complications developed after open reduction and internal fixation using multiple miniplates for accurate reduction of small fracture fragments. Therefore, when we use this technique, we need to pay attention to the development of complications such as nonunion, avascular necrosis, and osteomyelitis by the disruption of both endosteal blood supply by fracture and periosteal blood supply during approach or reduction...
May 2018: Journal of the American Podiatric Medical Association
Odette Fisher-Glover, Barbara Edlund, Emily Johnson
This quality improvement project evaluated whether offering a series of 5 structured interdisciplinary diabetic educational teaching sessions would improve glycemic control as measured by random blood sugars (RBS) in a Program of All-Inclusive Care for the Elderly (PACE). Five diabetic educational sessions were held over a 4-week period with 50 participants (N = 50). Data were analyzed and displayed using descriptive statistics and figures. Average RBS remained steady from 176.34 pre- to 175.52 post-intervention...
July 2017: Journal of National Black Nurses' Association: JNBNA
Ekrem İslamoğlu, Hakan Anıl, İbrahim Erol, Selim Taş, Mutlu Ateş, Murat Savaş
OBJECTIVE: To present the surgical and pathological results of robotic radical cystectomy (RRC) operations performed in our clinic. MATERIAL AND METHODS: A total of 18 patients, who underwent RRC and intracorporeal urinary diversion between October 2016 and September 2017 for clinically localized bladder cancer in our clinic, were included in the study. The results were evaluated under three headings. 1. operative outcomes (total operation time, perioperative blood loss, postoperative hematocrit decrease) 2...
July 2018: Turkish Journal of Urology
Thomas J Sorenson, Waleed Brinjikji, Kelly D Flemming, Giuseppe Lanzino
Incidental vascular lesions are being discovered at an increasing frequency due to widespread noninvasive brain imaging studies. One of these lesions has recently been termed a "pure arterial malformation" (PAM), which is defined as dilated, overlapping, and tortuous arteries forming a mass of arterial loops with a coil-like appearance in the absence of arteriovenous shunting. The pathogenesis of these lesions is not known, but a congenital etiology is suspected. The authors report the case of a 17-year-old female who was found to have a PAM of the posterior inferior cerebellar artery with adipose tissue interspersed within the arterial loops...
June 22, 2018: Journal of Neurosurgery. Pediatrics
Stine Ulrik Mikkelsen, Lasse Kjaer, Mads Emil Bjørn, Trine Alma Knudsen, Anders Lindholm Sørensen, Christen Bertel Lykkegaard Andersen, Ole Weis Bjerrum, Nana Brochmann, Daniel El Fassi, Torben A Kruse, Thomas Stauffer Larsen, Hans Torben Mourits-Andersen, Claus Henrik Nielsen, Niels Pallisgaard, Mads Thomassen, Vibe Skov, Hans Carl Hasselbalch
Interferon-α2 reduces elevated blood cell counts and splenomegaly in patients with myeloproliferative neoplasms (MPN) and may restore polyclonal hematopoiesis. Its use is limited by inflammation-mediated toxicity, leading to treatment discontinuation in 10-30% of patients. Ruxolitinib, a potent anti-inflammatory agent, has demonstrated benefit in myelofibrosis (MF) and polycythemia vera (PV) patients. Combination therapy (CT) with these two agents may be more efficacious than monotherapy with either, potentially improving tolerability of interferon-α2 as well...
June 22, 2018: Cancer Medicine
Cristina Alonso Madrigal, Manuela Dobón Rebollo, Viviana Laredo de la Torre, Luis Palomera Bernal, Francisco Agustín García Gil
INTRODUCTION: infection with the hepatitis C virus (HCV) causes significant morbidity and mortality in patients with hemophilia. Finally, patients are considered for a liver transplantation (LT) due to cirrhosis and/or hepatocellular carcinoma (HCC). MATERIAL AND METHODS: we report the cases of congenital coagulopathy and HCV infection that underwent LT in our institution. There were three patients with hemophilia A and one patient with von Willebrand disease (vWD) type 3...
June 22, 2018: Revista Española de Enfermedades Digestivas
Sern Wei Yeoh, Alex C N Holmes, Michael M Saling, Ian P Everall, Amanda J Nicoll
Patients with chronic hepatitis C virus (HCV) infection experience a range of symptoms including depression, fatigue and neurocognitive deficits, impairing quality of life. Depression, in particular, may be reactive to increased psychosocial stress, and the physical symptoms of advanced HCV or associated comorbidities. However, even patients at an early stage of HCV infection, with minimal hepatic inflammation or comorbidities, report more depressive symptoms and fatigue than the general population. Similarly, specific neurocognitive deficits occur in early stage HCV infection and are independent of the presence of depression or encephalopathy...
June 21, 2018: Hepatology International
Der-Ming Chang, Wei-Jei Lee, Jung-Chien Chen, Kong-Han Ser, Pei-Ling Tsai, Yi-Chih Lee
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has been validated as a safe and effective treatment for morbid obesity. However, data of the long-term outcome remains lacking. METHODS: A total of 1759 LSG was performed as primary bariatric procedure from 2005 to 2017 with mean age of 35.2 ± 10.3 years old (14-71), female 69.7%, mean body mass index (BMI) 37.9 ± 7.7 kg/m2 , and mean waist width 113.7 ± 17.9 cm. All patients were evaluated and managed under a strict multidisciplinary team approach...
June 21, 2018: Obesity Surgery
Karl Walsh, Ioannis Goutos, Baljit Dheansa
Acute acalculous cholecystitis (AAC) is an acute inflammatory disorder of the gallbladder, which can complicate the recovery of burn patients. No formal literature review has been performed about this uncommon but potentially fatal complication in burn care. A Pubmed search from 1950 to 2015 was performed using MESH terms: "acalculous cholecystitis," "burns or thermal injuries or thermal damage," and "cholecystitis or gallbladder inflammation." The articles were analyzed and data collected individually on the incidence, presenting symptoms or signs, risk factors, investigations, and treatment modalities used...
February 9, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
Mohsen Meidani, Masoome Baniasadi, Farzin Khorvash
Background: Increasing use of different chemotherapy regimens, organ transplants, etc., has led to the increasing number of neutropenic patients. Overall, 10% of patients affected by cancer who are under treatment with anticancer drugs, regardless of the tumor type, are susceptible to febrile neutropenia. The study was performed to evaluate the frequency of bloodstream fungal infections in pediatric patients with febrile neutropenia in Sayed Al-Shohada Hospital (Cancer Referral Center in Isfahan) in 2010-2012...
2018: Advanced Biomedical Research
James I Ausman, David S Liebeskind, Nestor Gonzalez, Jeffrey Saver, Neil Martin, J Pablo Villablanca, Paul Vespa, Gary Duckwiler, Reza Jahan, Tianyi Niu, Noriko Salamon, Bryan Yoo, Satoshi Tateshima, Manuel M Buitrago Blanco, Sidney Starkman
We have reviewed the English literature published in the last 70 years on Diseases of the Vertebral Basilar Circulation, or Posterior Circulation Disease (PCD). We have found that errors have been made in the conduct and interpretation of these studies that have led to incorrect approaches to the management of PCD. Because of the difficulty in evaluating the PC, the management of PCD has been incorrectly applied from anterior circulation disease (ACD) experience to PCD. PCD is a common form of stroke affecting 20-40% patients with stroke...
2018: Surgical Neurology International
Federica Tarquini, Elena Picchiassi, Giuliana Coata, Michela Centra, Vittorio Bini, Samanta Meniconi, Chiara Antonelli, Irene Giardina, Gian Carlo Di Renzo
The purpose of the present study was to search for associations between spontaneous preterm birth (sPTB), single nucleotide polymorphisms (SNPs) associated with the apoptotic pathway as triggered by oxidative stress, maternal lifestyle and health status. SNP genotyping [rs7560 for c-Jun N-terminal kinase (JNK), rs9517320 for mammalian STE20-like protein kinase 3 (MST3), rs1049216 for caspase 3 (CASP3)] in the placenta and maternal blood of 300 controls with at-term birth and 43 cases of sPTB was performed. No association was identified in genotype frequencies or combinations of foetal/maternal genotypes between single SNPs and sPTB...
July 2018: Biomedical Reports
H B Lin, Y Chen, P Shen, X Y Li, Y Q Si, D D Zhang, X Tang, P Gao
OBJECTIVE: To estimate the incidence rate and effects of risk factors on chronic kidney disease (CKD) in Chinese patients with diabetes, based on Electronic Health Records (EHRs) from the Chinese Electronic health Records Research in Yinzhou (CHERRY) Study. METHODS: Using the CHERRY cohort study with the individual-level information on chronic disease management; and health administrative, clinical and laboratory databases, patients with diabetes without kidney disease at baseline were enrolled and followed up from January 2009 through December 2016...
June 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Rachel C Orme, William A E Parker, Mark R Thomas, Heather M Judge, Kathleen Baster, Wael Sumaya, Kenneth P Morgan, Hannah C McMellon, James D Richardson, Ever D Grech, Nigel M Wheeldon, Ian R Hall, Javaid Iqbal, David Barmby, Julian P Gunn, Robert F Storey
Background -Ticagrelor has superior efficacy to clopidogrel in the management of acute coronary syndromes but has not been assessed in patients undergoing percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD). We compared the pharmacodynamic effects of ticagrelor and clopidogrel in this stable population. Methods -180 aspirin-treated stable CAD patients, who were planned to undergo elective PCI in a single center, were randomized 1:1:1 to either a standard clopidogrel regimen or one of two regimens of ticagrelor, either 90mg (T90) or 60mg twice-daily (T60), both with 180mg loading dose...
June 21, 2018: Circulation
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