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https://www.readbyqxmd.com/read/29913284/effect-sizes-of-bold-cvr-resting-state-signal-fluctuations-and-time-delay-measures-for-the-assessment-of-hemodynamic-impairment-in-carotid-occlusion-patients
#1
Jill B De Vis, Alex A Bhogal, Jeroen Hendrikse, Esben T Petersen, Jeroen C W Siero
BACKGROUND AND PURPOSE: The BOLD signal amplitude as a response to a hypercapnia stimulus is commonly used to assess cerebrovascular reserve. Despite recent advances, the implementation remains cumbersome and alternative ways to assess hemodynamic impairment are desirable. Resting-state BOLD signal fluctuations (rsBOLD) have been proposed however data on its sensitivity and dependence on baseline venous cerebral blood volume (vCBV) is limited. The primary aim of this study was to compare the effect sizes of resting-state and hypercapnia induced BOLD signal changes in the detection of hemodynamic impairment...
June 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29912952/effects-of-early-diuretic-response-to-carperitide-in-acute-decompensated-heart-failure-treatment-a-single-center-retrospective-study
#2
Yoshitaka Okuhara, Masanori Asakura, Kohei Azuma, Yoshiyuki Orihara, Koichi Nishimura, Tomotaka Ando, Hideyuki Kondo, Yoshiro Naito, Kazunori Kashiwase, Shinichi Hirotani, Masaharu Ishihara, Tohru Masuyama
BACKGROUND: Diuretic response is a strong predictor of outcome for admitted patients of acute decompensated heart failure (ADHF). However, little is known about the effects of early diuretic response to carperitide. METHODS: We retrospectively analyzed records of 85 patients hospitalized for ADHF who received carperitide as initial treatment and <40 mg furosemide during the early period. The eligible patients were divided into good diuretic responder (GR) group and poor diuretic responder (PR) group on the basis of median urinary volume...
2018: PloS One
https://www.readbyqxmd.com/read/29912924/hemodiafiltration-is-associated-with-reduced-inflammation-oxidative-stress-and-improved-endothelial-risk-profile-compared-to-high-flux-hemodialysis-in-children
#3
Ayşe Ağbaş, Nur Canpolat, Salim Çalışkan, Alev Yılmaz, Hakan Ekmekçi, Mark Mayes, Helen Aitkenhead, Franz Schaefer, Lale Sever, Rukshana Shroff
Randomized trials in adults have shown reduced all-cause and cardiovascular mortality on hemodiafiltration (HDF) compared to high-flux hemodialysis (HD), but the mechanisms leading to improved outcomes are not clear. We studied biomarkers of inflammation, oxidative stress, anti-oxidant capacity and endothelial dysfunction in 22 children (13 female, age 8-15 years). All children received HD for at least 3 months, and were then switched to HDF, keeping all dialysis related parameters and dialysis time constant...
2018: PloS One
https://www.readbyqxmd.com/read/29912067/rbc-exposure-in-pediatric-extracorporeal-membrane-oxygenation-epidemiology-and-factors-associated-with-large-blood-transfusion-volume
#4
Conor P O'Halloran, Peta M A Alexander, Kristofer G Andren, Jessica Mecklosky, Joshua W Salvin, Stephanie Larsen, Jill Zalieckas, Francis Fynn-Thompson, Ravi R Thiagarajan
OBJECTIVES: To quantify and identify factors associated with large RBC exposure in children supported with extracorporeal membrane oxygenation. DESIGN: Retrospective cohort study. SETTING: Single tertiary care children's hospital. PATIENTS: One-hundred twenty-two children supported with extracorporeal membrane oxygenation for greater than 12 hours during January 1, 2015, to December 31, 2016. INTERVENTIONS: None...
June 14, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29911484/the-need-for-an-alternative-method-to-determine-intravascular-volumes
#5
L M Lobigs, P Peeling, B Dawson, Y O Schumacher
It is well described that numerous environmental factors, including exercise, modulate plasma volume (PV). These modulations prove problematic when a number of haematological markers are measured as a concentration in blood plasma. A primary example is haemoglobin concentration ([Hb]), a marker of erythropoiesis commonly used within medicine and also used to detect blood doping. Natural changes in PV can confound [Hb] values when a volume change is detected rather than a true change in haemoglobin mass (Hbmass ) (e...
June 17, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29911022/adaptation-of-the-agyrophil-technique-for-nucleolar-organizer-regions-to-canine-peripheral-blood-smears
#6
John Ogunsola, Richard Antia
Nucleolar organizer regions (NORs) are chromosomal segments which are selectively stained by silver methods and evaluated as agyrophilic nucleolar organizer regions (AgNORs). The evaluation of AgNORs provides an insight into the level of cellular proliferation. This technique has extensively and sparsely been used in human and veterinary histopathology respectively. However, two major drawbacks have been irreproducible results and excessive staining precipitates. This study seeks to adapt the technique to canine peripheral blood smears in order to establish a routine staining protocol...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29910743/squeezing-for-life-properties-of-red-blood-cell-deformability
#7
REVIEW
Rick Huisjes, Anna Bogdanova, Wouter W van Solinge, Raymond M Schiffelers, Lars Kaestner, Richard van Wijk
Deformability is an essential feature of blood cells (RBCs) that enables them to travel through even the smallest capillaries of the human body. Deformability is a function of (i) structural elements of cytoskeletal proteins, (ii) processes controlling intracellular ion and water handling and (iii) membrane surface-to-volume ratio. All these factors may be altered in various forms of hereditary hemolytic anemia, such as sickle cell disease, thalassemia, hereditary spherocytosis and hereditary xerocytosis. Although mutations are known as the primary causes of these congenital anemias, little is known about the resulting secondary processes that affect RBC deformability (such as secondary changes in RBC hydration, membrane protein phosphorylation, and RBC vesiculation)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29910171/characterization-of-breast-lesion-using-t-1-perfusion-magnetic-resonance-imaging-qualitative-vs-quantitative-analysis
#8
S Thakran, P K Gupta, V Kabra, I Saha, P Jain, R K Gupta, A Singh
OBJECTIVES: The objective of this study was to quantify the hemodynamic parameters using first pass analysis of T1 -perfusion magnetic resonance imaging (MRI) data of human breast and to compare these parameters with the existing tracer kinetic parameters, semi-quantitative and qualitative T1 -perfusion analysis in terms of lesion characterization. MATERIALS AND METHODS: MRI of the breast was performed in 50 women (mean age, 44±11 [SD] years; range: 26-75) years with a total of 15 benign and 35 malignant breast lesions...
June 14, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29909774/cardiovascular-magnetic-resonance-assessment-of-acute-cardiovascular-effects-of-voluntary-apnoea-in-elite-divers
#9
L Eichhorn, J Doerner, J A Luetkens, J M Lunkenheimer, R C Dolscheid-Pommerich, F Erdfelder, R Fimmers, J Nadal, B Stoffel-Wagner, H H Schild, A Hoeft, B Zur, C P Naehle
BACKGROUND: Prolonged breath holding results in hypoxemia and hypercapnia. Compensatory mechanisms help maintain adequate oxygen supply to hypoxia sensitive organs, but burden the cardiovascular system. The aim was to investigate human compensatory mechanisms and their effects on the cardiovascular system with regard to cardiac function and morphology, blood flow redistribution, serum biomarkers of the adrenergic system and myocardial injury markers following prolonged apnoea. METHODS: Seventeen elite apnoea divers performed maximal breath-hold during cardiovascular magnetic resonance imaging (CMR)...
June 18, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29908993/priors-guided-slice-wise-adaptive-outlier-cleaning-for-arterial-spin-labeling-perfusion-mri
#10
Yiran Li, Sudipto Dolui, Dan-Feng Xie, Ze Wang
BACKGROUND: Due to the low signal-to-noise-ratio (SNR) and unavoidable head motions, the pairwise subtraction perfusion signal extraction process in arterial spin labeling (ASL) perfusion MRI can produce extreme outliers. COMPARISON WITH EXISTING METHODS: We previously proposed an adaptive outlier cleaning (AOC) algorithm for ASL MRI. While it performed well even for clinical ASL data, two issues still exist. One is that if the reference is already dominated by noise, outlier cleaning using low correlation with the mean as a rejection criterion will actually reject the less noisy samples but keep the more noisy ones...
June 14, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29908860/a-molecularly-imprinted-electrochemical-sensor-modified-with-nano-carbon-dots-with-high-sensitivity-and-selectivity-for-rapid-determination-of-glucose
#11
Wei Zheng, Haiyan Wu, Yan Jiang, Jicheng Xu, Xin Li, Wenchi Zhang, Fengxian Qiu
In this work, a novel molecularly imprinted electrochemical sensor (MIECS) based on a glassy carbon electrode (GCE) modified with carbon dots (CDs) and chitosan (CS) for the determination of glucose was proposed for the first time. The use of the environmental-friendly CDs and CS as electrode modifications improved the active area and electron-transport ability substantially, while 3-aminobenzeneboronic acid was used as a functional monomer and glucose as template for the fabrication of molecularly imprinted polymer (MIP) film to detect glucose via differential pulse voltammetry...
June 14, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29908806/preweaned-heifer-management-on-us-dairy-operations-part-ii-factors-associated-with-colostrum-quality-and-passive-transfer-status-of-dairy-heifer-calves
#12
C B Shivley, J E Lombard, N J Urie, D M Haines, R Sargent, C A Kopral, T J Earleywine, J D Olson, F B Garry
Passive transfer of immunity is essential for the short- and long-term health of dairy calves. The objective of this study was to evaluate factors associated with colostrum quality and passive transfer status of US heifer calves. This study included 104 operations in 13 states that participated in the calf component of the National Animal Health Monitoring System's Dairy 2014 study. This 18-mo longitudinal study included 1,972 Holstein heifer calves from birth to weaning. Multivariable mixed linear regression models were selected using backward elimination model selection after univariate screening to determine which factors were associated with colostrum IgG and serum IgG concentrations...
June 13, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29908395/a-novel-compliance-pressure-loop-approach-to-quantify-arterial-compliance-in-systole-and-in-diastole
#13
Mehmet Kaya, Vignesh Balasubramanian, Amit Patel, Yueya Ge, John K-J Li
Arterial compliance has been recognized as a critical parameter in governing pulsatile flow dynamics. It has traditionally been assumed constant throughout the cardiac cycle and its computation has been based either on the classic Windkessel model (C) in diastole or the stroke volume over pulse pressure (Cv ) method in systole. Other methods using area (Cam ) or two-area (Ctam ) and exponential (C(P)exp1 ) methods were used for the cardiac cycle. We proposed a novel compliance-pressure loop (CPP loop) approach for the quantification of arterial compliance and compared it to existing linear and nonlinear methods...
June 5, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29908345/functional-and-physiological-adaptations-following-concurrent-training-using-sets-with-and-without-concentric-failure-in-elderly-men-a-randomized-clinical-trial
#14
Eduardo Lusa Cadore, Erik Menger, Juliana Lopes Teodoro, Larissa Xavier Neves da Silva, Francesco Pinto Boeno, Daniel Umpierre, Cíntia Ehlers Botton, Rodrigo Ferrari, Giovani Dos Santos Cunha, Mikel Izquierdo, Ronei Silveira Pinto
This study compared the functional and physiological adaptations induced by concurrent training (CT) performed with repetitions to concentric failure and not to failure in elderly men. Fifty-two individuals (66.2 ± 5.2 years) completed the pre- and post-measurements and were divided into three groups: repetitions to failure (RFG, n = 17); repetitions not to failure (NFG, n = 20); and repetitions not to failure with total volume equalized to that in the RFG (ENFG, n = 15). The participants' sit-to-stand ability, timed-up-and-go (TUG), muscle power output in squat jump (SJ) and countermovement jump (CMJ), peak oxygen uptake (VO2peak ), blood lipids and glucose, as well as blood pressure levels were assessed...
June 13, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29908198/in-hospital-delays-result-in-worse-patient-outcomes-and-higher-cost-after-cardiac-surgery
#15
Diane R M Somlo, Nelson P Repenning, Abeel A Mangi
BACKGROUND: Contemporary reimbursement systems allow hospitals to maintain profitability by offering procedural services. However, increasing procedural volume can be met with structural inefficiencies that in turn cause delays, worse patient outcomes, and increased cost. METHODS: A multidisciplinary team assessed operations and outcomes at the Heart and Vascular Center at Yale New Haven Hospital, a tertiary academic medical center. Data were analyzed retrospectively to assess delays in transferring patients between care environments, patient outcomes, and cost...
June 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29907846/greater-blood-volume-and-hb-mass-in-obese-women-quantified-by-the-carbon-monoxide-rebreathing-method-affects-interpretation-of-iron-biomarkers-and-iron-requirements
#16
Ana C Cepeda-Lopez, Michael B Zimmermann, Sophia Wussler, Alida Melse-Boonstra, Nicole Naef, Sandro Manuel Mueller, Marco Toigo, Isabelle Herter-Aeberli
BACKGROUND/OBJECTIVE: Iron deficiency (ID) is common in overweight and obese individuals (OW/OB) but the mechanism is uncertain. Greater blood volume (BV) in OW/OB may increase hemoglobin (Hb) mass and iron requirements, and confound iron biomarkers by hemodilution. Quantification of BV/PV changes in OW/OB is challenging and a formula to estimate BV/PV based on anthropometric indices would be valuable. In normal weight (NW) and OW/OB women, we aimed at: (1) measure BV and assess whether differences in BV affect concentrations and total circulating mass of Hb and iron biomarkers; (2) develop an algorithm describing BV in OW/OB...
June 15, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29907502/functional-liver-image-guided-hepatic-therapy-flight-with-hepatobiliary-iminodiacetic-acid-hida-scans
#17
David E Long, Mark Tann, Ke Colin Huang, Gregory Bartlett, James O Galle, Yukie Furukawa, Mary Maluccio, John A Cox, Feng-Ming Spring Kong, Susannah G Ellsworth
PURPOSE: Hepatobiliary iminodiacetic acid (HIDA) scans provide global and regional assessments of liver function that can serve as a road map for functional avoidance in stereotactic body radiation therapy (SBRT) planning. Functional liver image guided hepatic therapy (FLIGHT), an innovative planning technique, is described and compared with standard planning using functional dose-volume histograms. Thresholds predicting for decompensation during follow up are evaluated. METHODS AND MATERIALS: We studied 17 patients who underwent HIDA scans before SBRT...
May 1, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29907235/rapid-valproic-acid-induced-modulation-of-the-traumatic-proteome-in-a-porcine-model-of-traumatic-brain-injury-and-hemorrhagic-shock
#18
Michael Weykamp, Vahagn C Nikolian, Isabel S Dennahy, Gerald A Higgins, Patrick E Georgoff, Henriette Remmer, Mohamed H Ghandour, Hasan B Alam
BACKGROUND: Histone deacetylase inhibitors such as valproic acid (VPA) improve survival in lethal models of hemorrhagic shock and polytrauma. Although VPA is known to modulate transcription, its ability to reduce mortality within minutes of administration suggests involvement of a rapid, posttranslational mechanism. We hypothesized that VPA treatment would cause proteomic changes within minutes of treatment including quantitative and/or posttranslational differences in structural and/or effector proteins...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907194/peripheral-venous-vs-capillary-microfilariaemia-in-a-dog-co-infected-with-dirofilaria-repens-and-d-immitis-a-comparative-approach-using-triatomine-bugs-for-blood-collection
#19
Ioana Raluca Păstrav, Angela Monica Ionică, Cosmin Peştean, Eva Novakova, David Modrý, Andrei Daniel Mihalca
Dirofilaria immitis and D. repens are mosquito-borne nematodes, primarily infecting dogs, but also other species of carnivores and even humans. Given their impact on animal and human health, the transmission of these filarioids has been widely studied. The microfilariaemia has been shown to have a circadian variation for both Dirofilaria species infecting dogs. Due to methodological difficulties, the periodicity was only studied using venous blood samples, while the mosquitoes feed, in fact, on capillary blood...
June 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29907130/acute-kidney-injury-is-associated-with-a-decrease-in-cortical-renal-perfusion-during-septic-shock
#20
Anatole Harrois, Nicolas Grillot, Samy Figueiredo, Jacques Duranteau
BACKGROUND: Renal perfusion status remains poorly studied at the bedside during septic shock. We sought to measure cortical renal perfusion in patients with septic shock during their first 3 days of care using renal contrast enhanced ultrasound (CEUS). METHODS: We prospectively included 20 ICU patients with septic shock and 10 control patients (CL) without septic shock admitted to a surgical ICU. Cortical renal perfusion was evaluated with CEUS during continuous infusion of Sonovue (Milan, Italy) within the first 24 h (day 0), between 24 and 48 h (day 1) and after 72 h (day 3) of care...
June 15, 2018: Critical Care: the Official Journal of the Critical Care Forum
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