keyword
MENU ▼
Read by QxMD icon Read
search

lycorine

keyword
https://www.readbyqxmd.com/read/29737624/leveraging-botanical-resources-for-crop-protection-the-isolation-bioactivity-and-structure-activity-relationships-of-lycoris-alkaloids
#1
Zhan Hu, Ziwen Wang, Liu Yuxiu, Qingmin Wang
BACKGROUND: Lycoris aurea (L' Herit.) Herb (Amaryllidaceae) is a native pesticide in China. The ethanolic extract of Lycoris aureate bulbs, the total alkaloids of L. aurea bulbs and the main alkaloids of L. aurea bulbs were systematically investigated as part of a novel project to study their antiviral, fungal (phytopathogenic) and insecticidal activities. We also prepared eighteen lycorine derivatives and evaluated their bioactivities. RESULTS: Lycorine had excellent larvacidal activity against Plutella xylostella (LC50 = 10...
May 8, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29561817/amaryllidaceae-alkaloids-as-potential-glycogen-synthase-kinase-3%C3%AE-inhibitors
#2
Daniela Hulcová, Kateřina Breiterová, Tomáš Siatka, Kamila Klímová, Lara Davani, Marcela Šafratová, Anna Hošťálková, Angela De Simone, Vincenza Andrisano, Lucie Cahlíková
Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine protein kinase that was originally identified as an enzyme involved in the control of glycogen metabolism. It plays a key role in diverse physiological processes including metabolism, the cell cycle, and gene expression by regulating a wide variety of well-known substances like glycogen synthase, tau-protein, and β-catenin. Recent studies have identified GSK-3β as a potential therapeutic target in Alzheimer´s disease, bipolar disorder, stroke, more than 15 types of cancer, and diabetes...
March 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29448253/lycorine-suppresses-endplate-chondrocyte-degeneration-and-prevents-intervertebral-disc-degeneration-by-inhibiting-nf-%C3%AE%C2%BAb-signalling-pathway
#3
Gangliang Wang, Kangmao Huang, Yangxin Dong, Shuai Chen, Jianfeng Zhang, Jiying Wang, Ziang Xie, Xianfeng Lin, Xiangqiang Fang, Shunwu Fan
BACKGROUND/AIMS: Cartilaginous endplate (CEP) degeneration is an important cause for intervertebral disc (IVD) degeneration that leads to low-back pain. The identification of compounds that may prevent CEP degeneration is of interest for the prevention of IVD degeneration. METHODS: Catabolic protease expression in the CEP of disc degeneration patients was first assessed. The toxicity, function and underlying mechanism of lycorine (LY) on CEP-derived chondrocytes degeneration were assessed in vitro by flow cytometry analysis and western blotting...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29442621/construction-of-fluorescein-isothiocyanate-labeled-msns-peg-lycorine-antibody-as-drug-carrier-for-targeting-prostate-cancer-cells
#4
Xiaoning Liu, Jingjing Kang, Hui Wang, Tao Huang, Chun Li
Lycorine possesses various pharmacological effects, including anti-tumor, antiviral, anti-malarial and anti-inflammatory properties, as well as a potential therapeutic against prostate cancer cells. Therefore, a drug carrier of lycorine with good biocompatibility, high drug loading capacity and good release ability is required to develop to gain maximum benefit from lycorine to target cancer cells. In this study, MSNs labeled with FITC and PEG were synthesized. These FITC-labeled MSNs/PEG/Lycorine/Antibody were loaded with lycorine and anti-EpCAM antibody, and analyzed for endocytosis, biocompatibility, drug loading and release ability...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29345138/a-four-step-synthesis-of-%C3%A2-%C3%AE-lycorane-via-pd0-catalyzed-double-c-sp2-h-c-sp3-h-arylation
#5
Ronan Rocaboy, David Dailler, Olivier Baudoin
An expedient synthesis of lycorine alkaloids is reported using a palladium(0)-catalyzed double C-X/C-H arylation as the key step. The selectivity of this reaction was controlled through the judicious choice of the two halogen atoms, and its generality was demonstrated through the construction of various substituted pyrrolophenanthridinones. A selective arene hydrogenation allowed for the completion of the synthesis of (±)-γ-lycorane in just four steps from commercially available precursors.
January 18, 2018: Organic Letters
https://www.readbyqxmd.com/read/29127013/lycorine-possesses-notable-anticancer-potentials-in-on-small-cell-lung-carcinoma-cells-via-blocking-wnt-%C3%AE-catenin-signaling-and-epithelial-mesenchymal-transition-emt
#6
Yanfang Sun, Pingping Wu, Yang Sun, Farukh S Sharopov, Qi Yang, Fangming Chen, Pan Wang, Zongsuo Liang
Lycorine, an natural isoquinoline alkaloid has reportedly that possesses multi-anticancer activity. However, to date, the anticancer feature of lycorine in non-small cell lung carcinoma (NSCLC) has still not fully been spelled out. The present study mainly focused on the molecular mechanism of lycorine against NSCLC in vitro and vivo. The results showed that lycorine evidently inhibited proliferation of A549 and H460 with IC50 values were 10.83 ± 1.14 μM and 12.35 ± 1.13 μM, while caused slight cytotoxicity in normal pulmonary epithelial Beas-2B cells, and arrested cell cycle in G0/G1 phase...
January 1, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28974556/lycorine-promotes-autophagy-and-apoptosis-via-tcrp1-akt-mtor-axis-inactivation-in-human-hepatocellular-carcinoma
#7
Haiyang Yu, Yuling Qiu, Xu Pang, Jian Li, Song Wu, Shuangshuang Yin, Lifeng Han, Yi Zhang, Chengyun Jin, Xiumei Gao, Wenwei Hu, Tao Wang
Lycorine is a multifunctional bioactive compound, and it possesses potential anticancer activities. However, little is known about the underlying mechanism. In this research, we have found that lycorine significantly induces the apoptotic and autophagic capacities of hepatocellular carcinoma (HCC) cells in vitro and in vivo Treatment with specific autophagy inhibitor (3-methyladenine/Bafilomycin A1) or knockdown of LC-3B/Atg5 by siRNA drastically enhances the apoptotic cell death effect by facilitating the switch from autophagy to apoptosis...
December 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28933285/anticancer-and-reversing-multidrug-resistance-activities-of-natural-isoquinoline-alkaloids-and-their-structure-activity-relationship
#8
Zhi-Xing Qing, Jia-Lu Huang, Xue-Yi Yang, Jing-Hong Liu, Hua-Liang Cao, Feng Xiang, Pi Cheng, Jian-Guo Zeng
The severe anticancer situation as well as the emergence of multidrug-resistant (MDR) cancer cells has created an urgent need for the development of novel anticancer drugs with different mechanisms of action. A large number of natural alkaloids, such as paclitaxel, vinblastine and camptothecin have already been successfully developed into chemotherapy agents. Following the success of these natural products, in this review, twenty-six types of isoquinoline alkaloid (a total of 379 alkaloids), including benzyltetrahydroisoquinoline, aporphine, oxoaporphine, isooxoaporphine, dimeric aporphine, bisbenzylisoquinoline, tetrahydroprotoberberine, protoberberine, protopine, dihydrobenzophenanthridine, benzophenanthridine, benzophenanthridine dimer, ipecac, simple isoquinoline, pavine, montanine, erythrina, chelidonine, tropoloisoquinoline, azafluoranthene, phthalideisoquinoline, naphthylisoquinoline, lycorine, crinane, narciclasine, and phenanthridone, were summarized based on their cytotoxic and MDR reversing activities against various cancer cells...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28910973/lycorine-inhibits-the-growth-and-metastasis-of-breast-cancer-through-the-blockage-of-stat3-signaling-pathway
#9
Jian Wang, Jie Xu, Guoqiang Xing
Signal transducer and activator of transcription 3 (STAT3) is involved in the growth and metastasis of breast cancer, and represents a potential target for developing new anti-tumor drugs. The purpose of this study is to investigate whether Lycorine, a pyrrolo[de]phenanthridine ring-type alkaloid extracted from Amaryllidaceae genera, could inhibit breast cancer by targeting STAT3 signaling pathway. The human breast cancer cell lines were incubated with various concentrations of Lycorine, and cell proliferation, colony formation, cell cycle distribution, apoptosis, migration and invasion were assayed by several in vitro approaches...
September 1, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28898076/acetylcholinesterase-inhibitory-alkaloids-from-the-whole-plants-of-zephyranthes-carinata
#10
Guanqun Zhan, Junfei Zhou, Junjun Liu, Jinfeng Huang, Hanqi Zhang, Rong Liu, Guangmin Yao
Eleven new alkaloids (1-11), classified as the 12-acetylplicamine (1), N-deformyl-seco-plicamine (2), plicamine (3-6), 4a-epi-plicamine (7), seco-plicamine (8), and lycorine (9-11) framework types, along with 15 known alkaloids (12-26) were isolated from the whole plants of Zephyranthes carinata. The structures of the new alkaloids 1-11 were established by extensive spectroscopic data interpretation. The absolute configurations of 9 and 10 were defined by single-crystal X-ray diffraction analysis. Zephycarinatines A (1), B (2), and G (7) represent the first examples of 12-acetylplicamine, N-deformyl-seco-plicamine, and 4a-epi-plicamine alkaloids, respectively...
September 22, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28809439/in-silico-profiling-of-the-biological-activities-of-amaryllidaceae-alkaloids
#11
Eman Shawky
OBJECTIVES: The large number of publications about Amaryllidaceae alkaloids reflects the abundance and variety in biological activity of these alkaloids. An in-silico approach was implemented in this work to rationalize the individual alkaloids to molecular biological activity. METHODS: A database was generated containing 313 Amaryllidaceae alkaloids which were then subjected to in-silico-validated structure-based virtual screening using extra precision (XP) approach of Glide docking program...
August 15, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28808407/in-vitro-cell-viability-by-cellprofiler-%C3%A2-software-as-equivalent-to-mtt-assay
#12
Luciana S Gasparini, Nayana D Macedo, Elisângela F Pimentel, Marcio Fronza, Valdemar L Junior, Warley S Borges, Eduardo R Cole, Tadeu U Andrade, Denise C Endringer, Dominik Lenz
OBJECTIVE: This study evaluated in vitro cell viability by the colorimetric MTT stands for 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay compared to image analysis by CellProfiler(®) software. MATERIALS AND METHODS: Hepatoma (Hepa-1c1c7) and fibroblast (L929) cells were exposed to isolated substances, camptothecin, lycorine, tazettine, albomaculine, 3-epimacronine, trispheridine, galanthine and Padina gymnospora, Sargassum sp...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28756149/anticancer-potential-of-amaryllidaceae-alkaloids-evaluated-by-screening-with-a-panel-of-human-cells-real-time-cellular-analysis-and-ehrlich-tumor-bearing-mice
#13
Radim Havelek, Darina Muthna, Pavel Tomsik, Karel Kralovec, Martina Seifrtova, Lucie Cahlikova, Anna Hostalkova, Marcela Safratova, Maria Perwein, Eva Cermakova, Martina Rezacova
In this study, twenty-two Amaryllidaceae alkaloids were screened for their anticancer potential. All isolates were evaluated for antiproliferative activities on a panel of 17 human cell types of different tissue origin using WST-1 assay. In addition, we determined the antiproliferative effect with a real-time cell analysis xCELLigence system. Thereafter, to evaluate the barely known in vivo anticancer potential of the most potent molecule haemanthamine, a preliminary study was performed using an Ehrlich tumor-bearing mice model...
September 25, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28649696/amaryllidaceae-alkaloids-absolute-configuration-and-biological-activity
#14
REVIEW
Alessio Cimmino, Marco Masi, Marco Evidente, Stefano Superchi, Antonio Evidente
Plants belonging to the Amaryllidaceae family are well known for their ornamental and medicinal use. Plant members of this group are distributed through both tropical and subtropical regions of the world and are dominant in Andean South America, the Mediterranean basin, and southern Africa. Amaryllidaceae plants have been demonstrated to be a good source of alkaloids with a large spectrum of biological activities, the latter being strictly related to the absolute stereochemistry of the alkaloid scaffold. Among them, great importance for practical applications in medicine has galanthamine, which has already spawned an Alzheimer's prescription drug as a potent and selective inhibitor of the enzyme acetylcholinesterase...
September 2017: Chirality
https://www.readbyqxmd.com/read/28579903/study-on-apoptosis-effect-of-human-breast-cancer-cell-mcf-7-induced-by-lycorine-hydrochloride-via-death-receptor-pathway
#15
Yubin Ji, Miao Yu, Zheng Qi, Di Cui, Guosong Xin, Bing Wang, Weiling Jia, Lin Chang
As research was conducted on the early apoptosis of human breast cancer cell MCF-7 caused by lycorine hydrochloride and the expression of the related apoptosis proteins. The early-period apoptosis rate of human breast cancer cell MCF-7 was tested with the AnnexinV/PI double staining and flow cytometry. The Western Blotting method was also used to detect the protein expression conditions of Fas, FasL, Caspase-8 and Bid. The results showed that the higher the dose, the higher the rate of apoptosis and that the rate of apoptosis was dependent on the dose; the relative protein activity of Fas, FasL, Caspase-8 and bid gradually rose with the increase of lycorine dosage and the activities revealed certain dose-independence...
May 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28450693/lycorine-induces-apoptosis-of-a549-cells-via-ampk-mammalian-target-of-rapamycin-mtor-s6k-signaling-pathway
#16
Hui Zeng, Rong Fu, Linxia Yan, Jian Huang
BACKGROUND This study was designed to investigate the effect of lycorine (LY) on the AMPK-mTOR-S6K signaling pathway and to clarify its role in autophagy and apoptosis. MATERIAL AND METHODS Various concentrations of LY were used to treat non-small cell lung carcinoma A549 cells. The MTT assay was used to measure cell viability and acridine orange staining was used to detect cell morphology changes. Western blot analysis was used to test the effect of LY on the expression levels of LC3, caspase 3, and other proteins involved in the AMPK-mTOR-S6K signaling pathway...
April 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28416753/synergistic-effects-of-the-immune-checkpoint-inhibitor-ctla-4-combined-with-the-growth-inhibitor-lycorine-in-a-mouse-model-of-renal-cell-carcinoma
#17
Xiezhao Li, Peng Xu, Chongshan Wang, Naijin Xu, Abai Xu, Yawen Xu, Takuya Sadahira, Motoo Araki, Koichiro Wada, Eiji Matsuura, Masami Watanabe, Junxia Zheng, Pinghua Sun, Peng Huang, Yasutomo Nasu, Chunxiao Liu
Renal cell carcinoma (RCC) management has undergone a major transformation over the past decade; immune checkpoint inhibitors are currently undergoing clinical trials and show promising results. However, the effectiveness of immune checkpoint inhibitors in patients with metastatic RCC (mRCC) is still limited. Lycorine, an alkaloid extracted from plants of the Amaryllidaceae family, is touted as a potential anti-cancer drug because of its demonstrative growth inhibition capacity (induction of cell cycle arrest and inhibition of vasculogenic mimicry formation)...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28251459/lycorine-inhibits-breast-cancer-growth-and-metastasis-via-inducing-apoptosis-and-blocking-src-fak-involved-pathway
#18
Xuexiang Ying, Anling Huang, Yajing Xing, Liping Lan, Zhengfang Yi, Pingqing He
Breast cancer is the most commonly diagnosed cancer type worldwide among women and more than 90% of patients die from tumor metastasis. Lycorine, a natural alkaloid, has been widely reported possessing potential efficacy against cancer proliferation and metastasis. In our study, the anti-tumor potency on breast cancer was evaluated in vitro and in vivo for the first time. Our results indicated that lycorine inhibited breast cancer cells growth, migration and invasion as well as induced their apoptosis. In in vivo study, lycorine not only suppressed breast tumor growth in xenograft models and inhibited breast tumor metastasis in MDA-MB-231 tail vein model...
February 27, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28240308/the-influences-of-four-types-of-soil-on-the-growth-physiological-and-biochemical-characteristics-of-lycoris-aurea-l-her-herb
#19
Miaohua Quan, Juan Liang
Based on the characteristics of Lycoris aurea (L. aurea) natural distribution and local soil types, we selected four representative types of soil, including humus soil, sandy soil, garden soil and yellow-brown soil, for conducting the cultivation experiments to investigate key soil factors influencing its growth and development and to select the soil types suitable for cultivating it. We found that there existed significant differences in the contents of mineral elements and the activities of soil enzymes (urease, phosphatase, sucrase and catalase) etc...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28044411/solid-phase-extraction-based-on-a-molecularly-imprinted-polymer-nanoshell-at-the-surface-of-silica-nanospheres-for-the-specific-enrichment-and-identification-of-alkaloids-from-crinum-asiaticum-l-var-sinicum
#20
Ruixiang Yang, Dong Zhu, Hongmei Wen, Anchen Fu, Zihan Zhao, Guoying Dai, Zhaoyi Miao, Yue Hu
A molecularly imprinted nanoshell on the surface of silica nanospheres was prepared for specific enrichment and identification of alkaloids from Crinum asiaticum L. var. sinicum. The nanoshell was synthesized by surface polymerization using lycorine as the template, acrylamide as the functional monomer, ethylene glycol dimethacrylate as the cross-linker, 2',2-azobisisobutyronitrile as the initiator and acetonitrile as the pore-forming agent. The core-shell nanospheres were characterized by transmission electron microscopy and infrared spectroscopy, and the results show that the nanoshell layer was homogeneously attached to the surface of vinyl-modified SiO2 nanospheres...
March 2017: Journal of Separation Science
keyword
keyword
18468
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"