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https://www.readbyqxmd.com/read/28731354/anionic-surfactants-on-anionic-substrate-monovalent-cation-binding
#1
Finian J Allen, Lucy Griffin, Richard M Alloway, Philipp Gutfreund, Seung Yeon Lee, Chris Leslie Truscott, Rebecca J L Welbourn, Mary H Wood, Stuart Matthew Clarke
Neutron reflectometry has been used to study the adsorption of the anionic surfactant bis(2-ethylhexyl) sulfosuccinate cesium salt (CsAOT) on the anionic surface of mica. Evidence of significant adsorption is reported. The adsorption is reversible and changes little with pH. This somewhat unexpected adsorption behaviour of an anionic molecule on an anionic surface is discussed in terms of recent models for surfactant adsorption such as cation bridging, where adsorption has been reported with the divalent ion calcium but not previously observed with monovalent ions...
July 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28730296/early-computed-tomography-or-focused-assessment-with-sonography-in-abdominal-trauma-what-are-the-leading-opinions
#2
L Grünherz, K O Jensen, V Neuhaus, L Mica, C M L Werner, B Ciritsis, C Michelitsch, G Osterhoff, H-P Simmen, K Sprengel
PURPOSE: The initial assessment of severely injured patients in the resuscitation room requires a systematic and quickly performed survey. Whereas the Advanced Trauma Life Support (ATLS(®))-based algorithm recommends focused assessment with sonography in trauma (FAST) among others, recent studies report a survival advantage of early whole-body computed tomography (WBCT) in haemodynamically stable as well as unstable patients. This study assessed the opinions of trauma surgeons about the early use of WBCT in severely injured patients with abdominal trauma, and abdominal CT in patients with isolated abdominal trauma, during resuscitation room treatment...
July 20, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28728044/atomic-force-microscopy-study-of-morphological-modifications-induced-by-different-decontamination-treatments-on-escherichia-coli
#3
Florina Lucica Zorila, Cristina Ionescu, Liviu Stefan Craciun, Bogdan Zorila
In this paper we used atomic force microscopy (AFM) to investigate the surface morphology of Escherichia coli, after being subjected to decontamination treatments, at sub-MICs levels (minimal inhibitory concentrations), with different disinfectants used in hospitals, pharmaceutical, food industry and even in our home, as an essential means to prevent the spreading of microorganisms. This article focuses on different morphological modifications adopted by E. coli cells as responses to the different modes of action of these substances...
July 14, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28727920/ballistic-penetration-of-highly-charged-nanoaerosol-particles-through-a-lipid-monolayer
#4
Victor N Morozov, Yuri M Shlyapnikov, Igor L Kanev, Elena Andreevna Shlyapnikova
To be used as a drug, inhaled nanoaerosol particles (NAPs) must first penetrate the lipid layer on top of the lung fluid before they will be able to reach the lung epithelium. We investigated how the penetration of NAPs through a model lipid monolayer (LM) depends upon their charging level and size. It was shown that deposition of NAPs 20-200 nm in diameter and charged to the Rayleigh limit gradually increased the surface tension of a dipalmitoylphosphatidylcholine monolayer (DPPC), indicating a loss of lipid molecules from the monolayer...
July 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28726859/surface-hydration-drives-rapid-water-imbibition-into-strongly-hydrophilic-nanopores
#5
Chao Fang, Rui Qiao
The imbibition of liquids into nanopores plays a critical role in numerous applications, and most prior studies focused on imbibition due to capillary flows. Here we report molecular simulations of the imbibition of water into single mica nanopores filled with pressurized gas. We show that, while capillary flow is suppressed by the high gas pressure, water is imbibed into the nanopore through surface hydration in the form of monolayer liquid films. As the imbibition front moves, the water film behind it gradually densifies...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28724544/mica-expressing-monocytes-enhance-natural-killer-cell-fc-receptor-mediated-antitumor-functions
#6
Amanda R Campbell, Megan C Duggan, Lorena P Suarez-Kelly, Neela Bhave, Kallan S Opheim, Elizabeth McMichael, Prashant Trikha, Robin Parihar, Eric Luedke, Adrian Lewis, Bryant Yung, Robert Lee, David Raulet, Susheela Tridandapani, Veronika Groh, Lianbo Yu, Vedat Yildiz, John C Byrd, Michael A Caligiuri, William E Carson
Natural Killer (NK) cells are large granular lymphocytes that promote the antitumor response via communication with other cell types in the tumor microenvironment. Previously, we have shown that NK cells secrete a profile of immune stimulatory factors (e.g., IFNgamma, MIP-1alpha, TNFalpha) in response to dual stimulation with the combination of antibody (Ab)-coated tumor cells and cytokines, such as interleukin (IL) 12. We now demonstrate that this response is enhanced in the presence of autologous monocytes...
July 19, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28722103/decreased-levels-of-active-upa-and-klk8-assessed-by-111-in-mica-401-binding-correlate-with-the-seizure-burden-in-an-animal-model-of-temporal-lobe-epilepsy
#7
Stephan Missault, Lore Peeters, Halima Amhaoul, David Thomae, Annemie Van Eetveldt, Barbara Favier, Anagha Thakur, Jeroen Van Soom, Asla Pitkänen, Koen Augustyns, Jurgen Joossens, Steven Staelens, Stefanie Dedeurwaerdere
OBJECTIVE: Urokinase-type plasminogen activator (uPA) and kallikrein-related peptidase 8 (KLK8) are serine proteases that contribute to extracellular matrix (ECM) remodeling after brain injury. They can be labelled with the novel radiotracer [(111) In]MICA-401. As the first step in exploring the applicability of [(111) In]MICA-401 in tracing the mechanisms of postinjury ECM reorganization in vivo, we performed in vitro and ex vivo studies, assessing [(111) In]MICA-401 distribution in the brain in two animal models: kainic acid-induced status epilepticus (KASE) and controlled cortical impact (CCI)-induced traumatic brain injury (TBI)...
July 19, 2017: Epilepsia
https://www.readbyqxmd.com/read/28708284/cd20-specific-immunoligands-engaging-nkg2d-enhance-%C3%AE-%C3%AE-t-cell-mediated-lysis-of-lymphoma-cells
#8
Matthias Peipp, Daniela Wesch, Hans-Heinrich Oberg, Sebastian Lutz, Anja Muskulus, Jan G J van de Winkel, Paul W H I Parren, Renate Burger, Andreas Humpe, Dieter Kabelitz, Martin Gramatzki, Christian Kellner
Human γδ T cells are innate-like T cells which are able to kill a broad range of tumor cells and thus may have potential for cancer immunotherapy. The activating receptor natural killer group 2 member D (NKG2D) plays a key role in regulating immune responses driven by γδ T cells. Here, we explored whether recombinant immunoligands consisting of a CD20 single-chain fragment variable (scFv) linked to a NKG2D ligand, either MHC class I chain-related protein A (MICA) or UL16 binding protein 2 (ULBP2), could be employed to engage γδ T cells for tumor cell killing...
July 14, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28703789/capturing-suboptical-dynamic-structures-in-lipid-bilayer-patches-formed-from-free-standing-giant-unilamellar-vesicles
#9
Tripta Bhatia, Flemming Cornelius, John H Ipsen
There is accumulating evidence that the small-scale lateral organization of biological membranes has a crucial role in signaling and trafficking in cells. However, it has been difficult to characterize these features with existing methods for preparing and analyzing freestanding membranes, because the dynamics occurs below the optical resolution possible with these protocols. We have developed a protocol that permits the imaging of lipid nanodomains and lateral protein organization in membranes of giant unilamellar vesicles (GUVs)...
August 2017: Nature Protocols
https://www.readbyqxmd.com/read/28702455/synergistic-interactions-of-a-synthetic-lubricin-mimetic-with-fibronectin-for-enhanced-wear-protection
#10
Roberto C Andresen Eguiluz, Sierra G Cook, Mingchee Tan, Cory N Brown, Noah J Pacifici, Mihir S Samak, Lawrence J Bonassar, David Putnam, Delphine Gourdon
Lubricin (LUB), a major mucinous glycoprotein of mammalian synovial fluids, is believed to provide excellent lubrication to cartilage surfaces. Consequently, when joint disease or replacement leads to increased friction and surface damage in the joint, robust synthetic LUB alternatives that could be used therapeutically to improve lubrication and surface protection are needed. Here, we report the characterization of a lubricating multiblock bottlebrush polymer whose architecture was inspired by LUB, and we investigate the role of fibronectin (FN), a glycoprotein found in the superficial zone of cartilage, in mediating the tribological properties of the polymer upon shear between mica surfaces...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28701757/oncolytic-measles-virus-enhances-antitumour-responses-of-adoptive-cd8-nkg2d-cells-in-hepatocellular-carcinoma-treatment
#11
Aiping Chen, Yonghui Zhang, Gang Meng, Dengxu Jiang, Hailin Zhang, Meihong Zheng, Mao Xia, Aiqin Jiang, Junhua Wu, Christian Beltinger, Jiwu Wei
There is an urgent need for novel effective treatment for hepatocellular carcinoma (HCC). Oncolytic viruses (OVs) not only directly lyse malignant cells, but also induce potent antitumour immune responses. The potency and precise mechanisms of antitumour immune activation by attenuated measles virus remain unclear. In this study, we investigated the potency of the measles virus vaccine strain Edmonston (MV-Edm) in improving adoptive CD8(+)NKG2D(+) cells for HCC treatment. We show that MV-Edm-infected HCC enhanced the antitumour activity of CD8(+)NKG2D(+) cells, mediated by at least three distinct mechanisms...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699345/nanostructural-tailoring-to-induce-flexibility-in-thermoelectric-ca3co4o9-thin-films
#12
Biplab Paul, Jun Lu, Per Eklund
Due to their inherent rigidity and brittleness, inorganic materials have seen limited use in flexible thermoelectric applications. On the other hand, for high output power density and stability, the use of inorganic materials is required. Here, we demonstrate a concept of fully-inorganic flexible thermoelectric thin films with Ca3Co4O9-on-mica. Ca3Co4O9 is promising not only due to its high Seebeck coefficient and good electrical conductivity but also important due to the abundance, low cost and nontoxicity of its constituent raw materials...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28697599/enhancement-of-friction-by-water-intercalated-between-graphene-and-mica
#13
Hyunsoo Lee, Jae-Hyeon Ko, Jin Sik Choi, Jin Heui Hwang, Yong-Hyun Kim, Miquel B Salmeron, Jeong Young Park
Common experience shows that friction converts mechanical energy into heat. The first part of this process is the vibrational excitation of the atoms at the interface between the rubbing bodies. The second and necessary part is the effective removal of this vibration energy by transfer from the contact region to the bulk substrate. A fundamental understanding of these phenomena is important for the design of improved tribological contact; however, this is difficult because excitation and dissipation are usually intimately entangled processes...
July 11, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28692797/versatile-large-area-custom-feature-van-der-waals-epitaxy-of-topological-insulators
#14
Tanuj Trivedi, Anupam Roy, Hema C P Movva, Emily S Walker, Seth R Bank, Dean P Neikirk, Sanjay K Banerjee
As the focus of applied research in topological insulators (TI) evolves, the need to synthesize large-area TI films for practical device applications takes center stage. However, constructing scalable and adaptable processes for high-quality TI compounds remains a challenge. To this end, a versatile van der Waals epitaxy (vdWE) process for custom-feature Bismuth Telluro-Sulfide TI growth and fabrication is presented, achieved through selective-area fluorination and modification of surface free-energy on mica...
July 10, 2017: ACS Nano
https://www.readbyqxmd.com/read/28691823/reversible-monolayer-bilayer-transition-in-supported-phospholipid-lb-films-under-the-presence-of-water-morphological-and-nanomechanical-behavior
#15
Silvia Ruíz-Rincón, Alejandro González Orive, Jesús M De La Fuente, Pilar Cea
Mixed monolayer Langmuir-Blodgett (LB) films of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and cholesterol (Chol) in the 1:1 ratio have been prepared onto solid mica substrates. Upon immersion in water or in an aqueous HEPES solution (pH 7.4) the monolayer LB films were spontaneously converted into well-organized bilayers leaving free mica areas. The process has been demonstrated to be reversible upon removal of the aqueous solution resulting in remarkably free of defects monolayers which are homogeneously distributed onto the mica...
July 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28691699/ancient-hydrothermal-seafloor-deposits-in-eridania-basin-on-mars
#16
Joseph R Michalski, Eldar Z Noe Dobrea, Paul B Niles, Javier Cuadros
The Eridania region in the southern highlands of Mars once contained a vast inland sea with a volume of water greater than that of all other Martian lakes combined. Here we show that the most ancient materials within Eridania are thick (>400 m), massive (not bedded), mottled deposits containing saponite, talc-saponite, Fe-rich mica (for example, glauconite-nontronite), Fe- and Mg-serpentine, Mg-Fe-Ca-carbonate and probable Fe-sulphide that likely formed in a deep water (500-1,500 m) hydrothermal setting...
July 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28689087/the-histone-deacetylase-inhibitor-saha-simultaneously-reactivates-hiv-1-from-latency-and-up-regulates-nkg2d-ligands-sensitizing-for-natural-killer-cell-cytotoxicity
#17
Maria Giovanna Desimio, Erica Giuliani, Margherita Doria
In pilot HIV-1 eradication studies, patients' immune responses were ineffective at killing viral reservoirs reactivated through latency reversing agents (LRAs) like suberoylanilide hydroxamic acid (SAHA). We hypothesized that T cells harboring reactivated HIV-1 express MIC and ULBP ligands for the activating NKG2D receptor of natural killer (NK) cells. Here, we demonstrated that MICA/B and ULBP2 are induced by SAHA on primary T cells harboring reactivated virus. Using latently HIV-1-infected J-Lat 6.3/8.4/9...
July 6, 2017: Virology
https://www.readbyqxmd.com/read/28684217/nkg2d-ligand-expression-in-crohn-s-disease-and-nkg2d-dependent-stimulation-of-cd8-t-cell-migration
#18
Kasper Vadstrup, Elisabeth Douglas Galsgaard, Helle Jensen, Lewis L Lanier, James C Ryan, Shih-Yu Chen, Garry P Nolan, Marianne Kajbæk Vester-Andersen, Julie Steen Pedersen, Jens Gerwien, Teis Jensen, Flemming Bendtsen
Interaction between the activating NKG2D receptor on lymphocytes and its ligands MICA, MICB, and ULBP1-6 modulate T and NK cell activity and may contribute to the pathogenesis of Crohn's disease (CD). NKG2D ligands are generally not expressed on the cell surface of normal, non-stressed cells, but expression of MICA and MICB in CD intestine has been reported. In this exploratory study, we further characterize the expression of NKG2D and its ligands, including the less well-described ULBP4-6, in CD, and test if NKG2D ligand interactions are involved in the migration of activated T cells into the affected mucosal compartments...
July 3, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28680748/mycn-is-an-immunosuppressive-oncogene-dampening-the-expression-of-ligands-for-nk-cell-activating-receptors-in-human-high-risk-neuroblastoma
#19
Elisa Brandetti, Irene Veneziani, Ombretta Melaiu, Annalisa Pezzolo, Aurora Castellano, Renata Boldrini, Elisa Ferretti, Doriana Fruci, Lorenzo Moretta, Vito Pistoia, Franco Locatelli, Loredana Cifaldi
Neuroblastoma (NB) is the most common extracranial solid tumor occurring in childhood. Amplification of the MYCN oncogene is associated with poor prognosis. Downregulation on NB cells of ligands recognized by Natural Killer (NK) cell-activating receptors, involved in tumor cell recognition and lysis, may contribute to tumor progression and relapse. Here, we demonstrate that in human NB cell lines MYCN expression inversely correlates with that of ligands recognized by NKG2D and DNAM1 activating receptors in human NB cell lines...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28679632/trends-in-mica-mica-adhesion-reflect-the-influence-of-molecular-details-on-long-range-dispersion-forces-underlying-aggregation-and-coalignment
#20
Dongsheng Li, Jaehun Chun, Dongdong Xiao, Weijiang Zhou, Huacheng Cai, Lei Zhang, Kevin M Rosso, Christopher J Mundy, Gregory K Schenter, James J De Yoreo
Oriented attachment of nanocrystalline subunits is recognized as a common crystallization pathway that is closely related to formation of nanoparticle superlattices, mesocrystals, and other kinetically stabilized structures. Approaching particles have been observed to rotate to achieve coalignment while separated by nanometer-scale solvent layers. Little is known about the forces that drive coalignment, particularly in this "solvent-separated" regime. To obtain a mechanistic understanding of this process, we used atomic-force-microscopy-based dynamic force spectroscopy with tips fabricated from oriented mica to measure the adhesion forces between mica (001) surfaces in electrolyte solutions as a function of orientation, temperature, electrolyte type, and electrolyte concentration...
July 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
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