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Ajay K Baranwal, Sanjeev Goswami, Deepali K Bhat, Gurvinder Kaur, Sanjay K Agarwal, Narinder K Mehra
BACKGROUND: Since soluble isoforms of MICA play an important role in modulating the immune response, we evaluated a possible correlation between their levels and development of acute rejection following renal transplantation. METHODS: Serum samples collected at pre- and different time points posttransplant from 137 live related donor renal transplant recipients were evaluated retrospectively for sMICA levels and for the presence of MICA antibodies. Samples from 30 healthy volunteers were also tested as controls...
January 9, 2018: Human Immunology
Maryam Nojabaee, Hsiu-Wei Cheng, Markus Valtiner, Jelena Popovic, Joachim Maier
Understanding of electrical double layers is essential to all electrochemical devices, particularly at high charge carrier concentrations. Using a combined approach (surface force apparatus, Zeta potential, infrared spectroscopy), we propose a model for the interfacial structure of triglyme electrolytes on muscovite Mica. In contact with the pure triglyme, a brush-like polymeric structure grows on the Mica surface. When lithium triflate is present in the triglyme, this structure is suppressed by anion adsorption and an extended double layer is formed...
January 11, 2018: Journal of Physical Chemistry Letters
Yang Mi, Zhixiong Liu, Qiuyu Shang, Xinxiang Niu, Jia Shi, Shuai Zhang, Jie Chen, Wenna Du, Zhiyong Wu, Rui Wang, Xiaohui Qiu, Xiaoyong Hu, Qing Zhang, Tom Wu, Xinfeng Liu
Recently, organometal halide perovskite-based optoelectronics, particularly lasers, have attracted intensive attentions because of its outstanding spectral coherence, low threshold, and wideband tunability. In this work, high-quality CH3 NH3 PbBr3 single crystals with a unique shape of cube-corner pyramids are synthesized on mica substrates using chemical vapor deposition method. These micropyramids naturally form cube-corner cavities, which are eminent candidates for small-sized resonators and retroreflectors...
January 10, 2018: Small
Zbigniew Adamczyk, Małgorzata Nattich-Rak, Maria Dąbkowska, Marta Kujda-Kruk
Adsorption of human serum albumin (HSA), recombinant HSA (rHSA) and the albumin dimer (dHSA) at solid/electrolyte interfaces is reviewed with the emphasis put on quantitative analysis of this process. Initially, various physicochemical data characterizing bulk properties of albumin molecules are discussed such as electrophoretic mobility, electrokinetic charge, zeta potential and diffusion coefficient. Adsorption kinetics of HSA, rHSA and dHSA at mica derived from AFM, streaming potential and XPS measurements is analyzed...
December 19, 2017: Journal of Colloid and Interface Science
Elizabeth Gensterblum-Miller, Weisheng Wu, Amr H Sawalha
The MHC region encodes HLA genes and is the most complex region in the human genome. The extensively polymorphic nature of the HLA hinders accurate localization and functional assessment of disease risk loci within this region. Using targeted capture sequencing and constructing individualized genomes for transcriptome alignment, we identified 908 novel transcripts within the human MHC region. These include 593 novel isoforms of known genes, 137 antisense strand RNAs, 119 novel long intergenic noncoding RNAs, and 5 transcripts of 3 novel putative protein-coding human endogenous retrovirus genes...
January 8, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Sheila López-Cobo, Natalia Pieper, Carmen Campos-Silva, Eva M García-Cuesta, Hugh T Reyburn, Annette Paschen, Mar Valés-Gómez
Therapy of metastatic melanoma advanced recently with the clinical implementation of signalling pathway inhibitors, such as vemurafenib, specifically targeting mutant BRAFV600E. In general, patients experience remarkable clinical responses under BRAF inhibitor (BRAFi) treatment but eventually progress within 6-8 months due to resistance development. Responding metastases show an increased immune cell infiltrate, including also NK cells, that, however, is no longer detectable in BRAFi-resistant lesions, suggesting NK cell activity should be exploited to prevent disease progression...
2018: Oncoimmunology
Stefanie Maurer, Korbinian Nepomuk Kropp, Gerd Klein, Alexander Steinle, Sebastian P Haen, Juliane S Walz, Clemens Hinterleitner, Melanie Märklin, Hans-Georg Kopp, Helmut Rainer Salih
Platelets promote metastasis, among others by coating cancer cells traveling through the blood, which results in protection from NK cell immune-surveillance. The underlying mechanisms, however, remain to be fully elucidated. Here we report that platelet-coating reduces surface expression of NKG2D ligands, in particular MICA and MICB, on tumor cells, which was mirrored by enhanced release of their soluble ectodomains. Similar results were obtained upon exposure of tumor cells to platelet-releasate and can be attributed to the sheddases ADAM10 and ADAM17 that are detectable on the platelet surface and in releasate following activation and at higher levels on platelets of patients with metastasized lung cancer compared with healthy controls...
2018: Oncoimmunology
Michael T McCarthy, Gerald Moncayo, Thomas K Hiron, Niels A Jakobsen, Alessandro Vali, Tomoyoshi Soga, Julie Adam, Christopher A O'Callaghan
Expression of the cell surface glycoprotein MHC class I polypeptide-related sequence A (MICA) is induced in dangerous, abnormal or 'stressed' cells, including cancer cells, virus-infected cells and rapidly proliferating cells. MICA is recognized by the activating immune cell receptor NKG2D, providing a mechanism by which immune cells can identify and potentially eliminate pathological cells. Immune recognition through NKG2D is implicated in cancer, atherosclerosis, transplant rejection and inflammatory diseases such as rheumatoid arthritis...
December 26, 2017: Journal of Biological Chemistry
Juliette Experton, Xiaojian Wu, Charles R Martin
Asymmetrically shaped nanopores have been shown to rectify the ionic current flowing through pores in a fashion similar to a p-n junction in a solid-state diode. Such asymmetric nanopores include conical pores in polymeric membranes and pyramidal pores in mica membranes. We review here both theoretical and experimental aspects of this ion current rectification phenomenon. A simple intuitive model for rectification, stemming from previously published more quantitative models, is discussed. We also review experimental results on controlling the extent and sign of rectification...
December 14, 2017: Nanomaterials
K O Jensen, R Heyard, D Schmitt, L Mica, C Ossendorf, H P Simmen, G A Wanner, C M L Werner, L Held, K Sprengel
PURPOSE: To find ways to reduce the rate of over-triage without drastically increasing the rate of under-triage, we applied a current guideline and identified relevant pre-hospital triage predictors that indicate the need for immediate evaluation and treatment of severely injured patients in the resuscitation area. METHODS: Data for adult trauma patients admitted to our level-1 trauma centre in a one year period were collected. Outpatients were excluded. Correct triage for trauma team activation was identified for patients with an ISS or NISS ≥ 16 or the need for ICU treatment due to trauma sequelae...
December 13, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Toshinori Motegi, Kenji Yamazaki, Toshio Ogino, Ryugo Tero
The solid-substrate-dependent structure and dynamics of molecules in a supported lipid bilayer (SLB) were directly investigated via atomic force microscopy (AFM) and single particle tracking (SPT) measurements. The appearance of either vertical or horizontal heterogeneities in the SLB was found to be strongly dependent on the underlying substrates. SLB has been widely used as a biointerface with incorporated proteins and other biological materials. Both silica and mica are popular substrates for SLB. Using single-molecule dynamics, the fluidity of the upper and lower membrane leaflets was found to depend on the substrate, undergoing coupling and decoupling on the SiO2/Si and mica substrates, respectively...
December 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Fan Wang, Pai-Lan Peng, Xue Lin, Ying Chang, Jing Liu, Rui Zhou, Jia-Yan Nie, Wei-Guo Dong, Qiu Zhao, Jin Li
The role of intestinal lamina propria (LP) NKG2D+ NK cells is unclear in regulating Th1/Th2 balance in ulcerative colitis (UC). In this study, we investigated the frequency of LP NKG2D+ NK cells in DSS-induced colitis model and intestinal mucosal samples of UC patients, as well as the secretion of Th1/Th2/Th17 cytokines in NK cell lines after MICA stimulation. The role of Th1 cytokines in UC was validated by bioinformatics analysis. We found that DSS-induced colitis in mice was characterized by a Th2-mediated process...
November 17, 2017: Oncotarget
Qingye Lu, Jun Huang, Omar Maan, Yang Liu, Hongbo Zeng
Surface fouling is the dominant fouling mechanism of thin-film composite (TFC) membranes used in reverse osmosis (RO) technology. Understanding the complex interactions between foulant-membrane which drive the attachment and growth of foulants on membrane surface is of both fundamental and practical importance. This work aims to understand the molecular interaction mechanisms of organic fouling on RO-TFC membranes. A surface forces apparatus (SFA) was employed to directly measure the interaction forces and time-dependent adsorption behaviors between model organic foulants: humic acid (HA), bovine serum albumin (BSA), and lipopolysaccharides (LPS) and a polyamide (PA) thin film...
December 6, 2017: Science of the Total Environment
Yijing Zhao, Naifei Chen, Yu Yu, Lili Zhou, Chao Niu, Yudi Liu, Huimin Tian, Zheng Lv, Fujun Han, Jiuwei Cui
Purpose: MHC class I chain related-proteins A (MICA) and B (MICB) are natural killer group 2D ligands that mediate tumor surveillance. Several studies have suggested that MICA/B levels predict clinical outcomes in patients with cancer; however, this remains contentious. Here, we present a systematic review and meta-analysis of available studies of the prognostic value of MICA/B in cancer. Materials and Methods: We searched PubMed, Embase,, and Cochrane Library to identify studies published from inception to July 2017 that assessed MICA/B in patients with cancer...
November 10, 2017: Oncotarget
Clemens Scheuner, Steffen Jankuhn, Jürgen Vogt, Sébastien Pezzagna, Christina Trautmann, Jan Meijer
Long channels with diameter of few tens of nanometer are produced by chemical track etching of swift heavy ion irradiated muscovite sheets. Such small apertures are most suitable e.g. as beam defining apertures for focusing systems in ion beam facilities enabling beam diameters down to a few nanometers. One of the most important parameters to consider is the interaction of the ion beam with the walls of the aperture. We report angle-resolved transmission and energy-loss measurements of MeV ion beams through ion-track-etched capillaries with very high aspect ratio of about 60...
December 6, 2017: Scientific Reports
M R El-Naggar, M Amin
Radio-cesium constitutes major environmental threats. Sorption of hazardous species onto geopolymeric sorbents is relatively recent and may give information about the retention mechanisms when geopolymers are applied to immobilize radwastes. Here, Na-MK, K-MK, Na-MKBFS, and K-MKBFS geopolymeric sorbents were synthesized from metakaolin (MK) and blast furnace slag (BFS) and were characterized using XRD, XRF, FT-IR, DTA/TGA and SEM. FT-IR/XRF results clarified the impact of mono-valent alkali cation (M+) in dividing the sorbents into Al-rich (sodium-based) and Si-rich (potassium-based)...
November 27, 2017: Journal of Hazardous Materials
Suchiwa Pan-On, Soravoot Rujivipat, Anan Ounaroon, Waree Tiyaboonchai
OBJECTIVE: To develop clay facial mask containing turmeric extract solid dispersion (TESD) for enhancing curcumin water solubility and permeability and to determine suitable clay based facial mask. METHODS: The TESD were prepared by solvent and melting solvent method with various TE to PVP K30 mass ratios. The physicochemical properties, water solubility and permeability were examined. The effects of clay types on physical stability of TESD, water adsorption and curcumin adsorption capacity were evaluated...
November 30, 2017: Drug Development and Industrial Pharmacy
Ileana F Márquez, Marisela Vélez
We describe a simple way of fusing E. coli lipid vesicles onto a gold surface. Supported lipid bilayers on metal surfaces are interesting for several reasons: transducing a biological signal to an electric readout, using surface analytical tools such as Surface Plasmon Resonance (SPR), Infrared Reflection Absorption Spectroscopy, Neutron Reflectivity or Electrochemistry. The most widely used method to prepare supported lipid membranes is fusion of preexisting liposomes. It is quite efficient on hydrophilic surfaces such as glass, mica or SiO2, but vesicle fusion on metals and metal oxide surfaces (as gold, titanium oxide or indium tin oxide), remains a challenge, particularly for vesicles containing charged lipids, as is the case of bacterial lipids...
2017: MethodsX
Xiao-Yan Fan, Peng-Yu Wang, Chao Zhang, Yu-Long Zhang, Yun Fu, Cong Zhang, Qiao-Xia Li, Jie-Na Zhou, Bao-En Shan, Dong-Wei He
To determine the growth inhibition capability of all-trans retinoic acid (ATRA) with cytokine-induced killer cells (CIKs), we evaluated their effects, alone and in combination, on human lung carcinoma A549 cells. CIKs treated with ATRA significantly inhibited cell growth. Additionally, CIK with ATRA synergistically inhibited migration and invasiveness, colony formation of A549 and NCI-H520 cells. Furthermore, analysis of apoptosis markers Bcl-2, Bax, Survivin and cleaved Caspase-3 showed that Bcl-2 and Survivin mRNA levels significantly decreased, and that Bax mRNA significantly increased, in the CIK + ATRA-treated cells, with corresponding effects on their respective proteins...
November 28, 2017: Scientific Reports
Narmadha Subramanian, Zeguang Wu, Frank Reister, Kerstin Laib Sampaio, Giada Frascaroli, Luka Cicin-Sain, Thomas Mertens
Apart from classical antigen-presenting cells (APCs) like dendritic cells and macrophages, there are semiprofessional APCs such as endothelial cells (ECs) and Langerhans' cells. Human cytomegalovirus (HCMV) infects a wide range of cell types including the ECs which are involved in the trafficking and homing of T cells. By investigating the interaction of naïve T cells obtained from HCMV-seronegative umbilical cord blood with autologous HCMV-infected human umbilical vein ECs (HUVECs), we could show that the activation of naïve T cells occurred after 1 day of peripheral blood mononuclear cell (PBMC) exposure to HCMV-infected HUVECs...
November 21, 2017: Journal of General Virology
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