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https://www.readbyqxmd.com/read/28820526/silica-nanoparticle-monolayers-on-a-macroion-modified-surface-formation-mechanism-and-stability
#1
M Morga, Z Adamczyk, D Kosior
Even though silica nanoparticles and their monolayers find a broad field of applications, only a few studies providing a quantitative description of silica nanoparticle deposition at solid/liquid interfaces have been reported in the literature. Given the deficit of reliable experimental data, the goal of this work is to acquire thorough physicochemical characteristics of amorphous silica nanoparticle deposition. Silica nanoparticle monolayers of controlled coverage were formed on macroion (PAH)-modified mica...
August 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28819213/in-vivo-regulation-of-glycogen-synthase-kinase-3%C3%AE-activity-in-neurons-and-brains
#2
Ambika Krishnankutty, Taeko Kimura, Taro Saito, Kyota Aoyagi, Akiko Asada, Shin-Ichiro Takahashi, Kanae Ando, Mica Ohara-Imaizumi, Koichi Ishiguro, Shin-Ichi Hisanaga
Glycogen synthase kinase 3β (GSK3β) is a multifunctional protein kinase involved in many cellular activities including development, differentiation and diseases. GSK3β is thought to be constitutively activated by autophosphorylation at Tyr216 and inactivated by phosphorylation at Ser9. The GSK3β activity has previously been evaluated by inhibitory Ser9 phosphorylation, but it does not necessarily indicate the kinase activity itself. Here, we applied the Phos-tag SDS-PAGE technique to the analysis of GSK3β phosphoisotypes in cells and brains...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811958/soluble-nkg2d-ligands-are-biomarkers-associated-with-the-clinical-outcome-to-immune-checkpoint-blockade-therapy-of-metastatic-melanoma-patients
#3
Cristina Maccalli, Diana Giannarelli, Carla Chiarucci, Ornella Cutaia, Gianluca Giacobini, Wouter Hendrickx, Giovanni Amato, Diego Annesi, Davide Bedognetti, Maresa Altomonte, Riccardo Danielli, Luana Calabrò, Anna Maria Di Giacomo, Francesco M Marincola, Giorgio Parmiani, Michele Maio
The introduction of immune checkpoint blockade into the clinical practice resulted in improvement of survival of a significant portion of melanoma patients. Consequently, predictive biomarkers of response are needed to optimize patient's stratification and the development of combination therapies. The aim of this study was to determine whether levels of soluble NKG2D ligands (MICA, MICB, ULBP1, 2 and 3; sNKG2DLs) in the serum of melanoma patients can serve as useful predictors of response to the treatment with immune checkpoint blockade...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28804926/van-der-waals-epitaxial-growth-of-2d-metallic-vanadium-diselenide-single-crystals-and-their-extra-high-electrical-conductivity
#4
Zhepeng Zhang, Jingjing Niu, Pengfei Yang, Yue Gong, Qingqing Ji, Jianping Shi, Qiyi Fang, Shaolong Jiang, He Li, Xiebo Zhou, Lin Gu, Xiaosong Wu, Yanfeng Zhang
2D metallic transition-metal dichalcogenides (MTMDs) have recently emerged as a new class of materials for the engineering of novel electronic phases, 2D superconductors, magnets, as well as novel electronic applications. However, the mechanical exfoliation route is predominantly used to obtain such metallic 2D flakes, but the batch production remains challenging. Herein, the van der Waals epitaxial growth of monocrystalline, 1T-phase, few-layer metallic VSe2 nanosheets on an atomically flat mica substrate via a "one-step" chemical vapor deposition method is reported...
August 14, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28803679/systematic-review-of-the-methods-predictive-of-the-functionality-of-kidney-transplantation
#5
E Miret Alomar, E Trilla Herrera, D Lorente Garcia, L Regis Placido, R López Del Campo, M Cuadras Solé, T Pont Castellana, F Moreso Mateos, D Serón Micas, J Morote Robles
CONTEXT: Kidney transplantation from donors with expanded criteria has increased the pool of kidneys at the cost of a higher risk of short and long-term graft dysfunction. The main issue lies in determining which kidneys will offer acceptable function and survival compared with the risk represented by surgery and subsequent immunosuppression. OBJECTIVE: The objective of our article is to review the current evidence on the tools for predicting the functionality of kidney transplantation from cadaveric donors with expanded criteria and determining the validity for their use in standard practice...
August 10, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28795749/poly-styrene-co-butadiene-random-copolymer-thin-films-and-nanostructures-on-a-mica-surface-morphology-and-contact-angles-of-nanodroplets
#6
Jake McClements, Cosimo Buffone, Michael P Shaver, Khellil Sefiane, Vasileios Koutsos
The self-assembly of poly(styrene-co-butadiene) random copolymers on mica surfaces was studied by varying solution concentrations and polymer molecular weights. Toluene solutions of the poly(styrene-co-butadiene) samples were spin coated onto a mica surface and the resulting polymer morphology was investigated by atomic force microscopy. At higher concentrations, thin films formed with varying thicknesses; some dewetting was observed which depended on the molecular weight. Total dewetting did not occur despite the polymer's low glass transition temperature...
August 10, 2017: Soft Matter
https://www.readbyqxmd.com/read/28789536/computational-simulations-of-solvation-force-and-squeezing-out-of-dodecane-chain-molecules-in-an-atomic-force-microscope
#7
Rong-Guang Xu, Yuan Xiang, Yongsheng Leng
Understanding the squeeze out behaviors of liquid films at nanometer scale in an atomic force microscope (AFM) has been a significant interest since the 1990s. We carry out all-atom static-mode AFM simulations in a liquid-vapor molecular dynamics ensemble to investigate the solvation force oscillation and squeeze out mechanisms of a confined linear dodecane fluid between a gold AFM tip and a mica substrate. Solvation force oscillations are found to be associated with the layering transition of the liquid film and unstable jumps of the AFM tip...
August 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28782775/sequential-nested-assembly-at-the-liquid-solid-interface
#8
Baharan Karamzadeh, Thomas Eaton, David Muñoz Torres, Izabela Cebula, Marcel Mayor, Manfred Buck
Studying the stepwise assembly of a four component hybrid structure on Au(111)/mica, the pores of a hydrogen bonded bimolecular network of 3,4,9,10-perylenetetracarboxylic diimide (PTCDI) and 1,3,5-triazine-2,4,6-triamine (melamine) were partitioned by three and four-armed molecules based on oligo([biphenyl]-4-ylethynyl)benzene, followed by the templated adsorption of either C60 fullerene or adamantane thiol molecules. The characterisation by ambient scanning tunneling microscopy (STM) reveals that the pore modifiers exhibit dynamics which pronouncedly depend on the molecular structure...
August 7, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28771222/microrna-519a-3p-mediates-apoptosis-resistance-in-breast-cancer-cells-and-their-escape-from-recognition-by-natural-killer-cells
#9
Christian Breunig, Jens Pahl, Moritz Küblbeck, Matthias Miller, Daniela Antonelli, Nese Erdem, Cornelia Wirth, Rainer Will, Alexander Bott, Adelheid Cerwenka, Stefan Wiemann
Aggressive breast cancer is associated with poor patient outcome and characterized by the development of tumor cell variants that are able to escape from control of the immune system or are resistant to targeted therapies. The complex molecular mechanisms leading to immune escape and therapy resistance are incompletely understood. We have previously shown that high miR-519a-3p levels are associated with poor survival in breast cancer. Here, we demonstrate that miR-519a-3p confers resistance to apoptosis induced by TRAIL, FasL and granzyme B/perforin by interfering with apoptosis signaling in breast cancer cells...
August 3, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28770981/interaction-forces-between-pegylated-star-shaped-polymers-at-mica-surfaces
#10
Xavier Banquy, Frantz Le Dévédec, Hsiu-Wei Cheng, Jimmy Faivre, Julian X X Zhu, Markus Valtiner
We present a study focused on characterizing the interaction forces between mica surfaces across solutions containing star-shaped polymers with cationic ends. Using the surface forces apparatus, we show that the interaction forces in pure water between surfaces covered with the polymers can be adequately described by the dendronized brush model. In that framework, our experimental data suggest that the number of branches adsorbed at the surface decreases as the concentration of polymer in the adsorbing solution increases...
August 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28767439/resveratrol-promotes-mica-b-expression-and-natural-killer-cell-lysis-of-breast-cancer-cells-by-suppressing-c-myc-mir-17-pathway
#11
Jie Pan, Jiaying Shen, Wengong Si, Chengyong Du, Danni Chen, Liang Xu, Minya Yao, Peifen Fu, Weimin Fan
Major histocompatibility complex class I chain-related proteins A and B (MICA and MICB) are important ligands for recognition of tumor cells by immune effector cells. Here, we report that resveratrol upregulated the protein and mRNA expression of MICA and MICB in breast cancer cells, which in turn promoted breast cancer cell lysis by natural killer (NK) cells in vitro and in vivo. Antibodies against NK group 2 member D blocked this effect. The 3'-untranslated regions of MICA and MICB were found to be direct binding targets of miR-17...
July 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28759240/strong-stretching-of-poly-ethylene-glycol-brushes-mediated-by-ionic-liquid-solvation
#12
Mengwei Han, Rosa M Espinosa-Marzal
We have measured forces between mica surfaces coated with a poly(ethylene glycol) (PEG) brush solvated by a vacuum dry ionic liquid, 1-ethyl-3-methyl imidazolium bis(trifluoromethylsulfonyl)imide, with a surface forces apparatus. At high grafting density, the solvation mediated by the ionic liquid causes the brush to stretch twice as much as in water. Modeling of the steric repulsion indicates that PEG behaves as a polyelectrolyte; the hydrogen bonding between ethylene glycol and the imidazolium cation seems to effectively charge the polymer brush, which justifies the strong stretching...
July 31, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28756360/combined-intra-and-extraperitoneal-urinary-bladder-rupture-a-rare-seat-belt-injury-a-case-report
#13
Lisanne Grünherz, Xenia Startseva, Marko Kozomara-Hocke, Borna K Barth, Hans-Peter Simmen, Ladislav Mica, Thomas Rauer
INTRODUCTION: While isolated traumatic urinary bladder injuries are rare, combined intra- and extraperitoneal traumatic urinary bladder ruptures without an underlying fracture are an absolute rarity. PRESENTATION OF CASE: We report a case of combined intra- and extraperitoneal urinary bladder rupture without an underlying fracture resulting from blunt abdominal trauma during a high velocity car accident. A midline laparotomy was performed, and the intra- and extraperitoneal bladder ruptures were surgically treated...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28752674/association-of-mica-129-polymorphism-and-circulating-soluble-mica-level-with-rheumatoid-arthritis-in-a-south-indian-tamil-population
#14
Christina M Mariaselvam, Wahid Boukouaci, Dominique Charron, Rajagopal Krishnamoorthy, Ryad Tamouza, Durga P Misra, Vir S Negi
INTRODUCTION: Rheumatoid arthritis (RA) is a clinically heterogeneous chronic inflammatory disorder characterized by synovitis leading to joint destruction. Both genetic and environmental factors are involved in the pathogenesis of RA. Significant dysregulation of NKG2D, an activating receptor of natural killer and certain autoreactive T cells as well as its ligand major histocompatibility complex class I chain-related gene A (MICA) has been implicated in perpetuating the pathology of RA...
July 27, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28742417/mica-129met-val-polymorphism-is-associated-with-early-onset-breast-cancer-risk
#15
Nesrine Ouni, Arij Ben Chaaben, Ghalia Kablouti, Mohamed Lajnef, Fayza Ayari, Hajer Abaza, Tarek Damak, Latifa Harzallah, Amel Benammar-Elgaaeid, Fethi Guemira, Ryad Tamouza
The major histocompatibility complex class I-related chain A (MICA), expressed on cell surface, plays an important role in the elimination of both virus-infected cells and tumor through the activation of the natural killer (NK) receptor NKG2D. A polymorphic change from methionine (Met) to valine (Val) at amino acid position 129 categorizes MICA alleles into strong and weak binders for the NKG2D receptor and has been found in a variety of immune-related disorders. In this study, we investigated the potential interaction between genetic polymorphism of MICA and the development of breast cancer...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28735200/ion-specific-hydration-in-nano-confined-electrical-double-layers
#16
Z Zachariah, R M Espinosa-Marzal, M P Heuberger
We probe counter-ion specific effects in nano-confined electrical-double-layers (EDLs) by means of direct force measurements across a model slit pore in the extended surface forces apparatus. By variation of solution composition, we compare four different counter-ions with dissimilar hydration properties, namely Na(+), K(+), Cs(+) as well as H3O(+), all confined between (001) mica surfaces. We discuss the results in terms of a recently proposed π-transition model, evoking hydrated ion layering as the recurrent structural element in highly confined EDLs...
July 14, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28732877/enhanced-antitumor-activity-of-gemcitabine-by-polysaccharide-induced-nk-cell-activation-and-immune-cytotoxicity-reduction-in-vitro-vivo
#17
Xin Xie, Yiran Zhou, Xue Wang, Jian Guo, Jingwen Li, Hongye Fan, Jie Dou, Baiyong Shen, Changlin Zhou
The polysaccharide SEP has been reported to activate NK and T cells via TLR2/4. Here, the combination of gemcitabine (GEM) and SEP against HepG-2 was investigated. SEP apparently enhanced antitumor activity of gemcitabine against liver cancer through stimulating NKG2D and DAP10/Akt pathway to activate NK cells. The NKG2D upregulation could improve the sensitivity of NK-92 cells targeting to its ligand MICA expressed on HepG-2 cells. Meanwhile, GEM up-regulated MICA expression and attenuated soluble MICA secretion through inhibiting ADAM10 expression, which in turn enhanced the cytotoxicity of NK-92 cells against cancer cells...
October 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28731354/an-anionic-surfactant-on-an-anionic-substrate-monovalent-cation-binding
#18
Finian J Allen, Lucy R Griffin, Richard M Alloway, Philipp Gutfreund, Seung Yeon Lee, Chris L Truscott, Rebecca J L Welbourn, Mary H Wood, Stuart M Clarke
Neutron reflectometry has been used to study the adsorption of the anionic surfactant bis(2-ethylhexyl) sulfosuccinate cesium salt on the anionic surface of mica. Evidence of significant adsorption is reported. The adsorption is reversible and changes little with pH. This unexpected adsorption behavior of an anionic molecule on an anionic surface is discussed in terms of recent models for surfactant adsorption such as cation bridging, where adsorption has been reported with the divalent ion calcium but not previously observed with monovalent ions...
August 3, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28730296/early-computed-tomography-or-focused-assessment-with-sonography-in-abdominal-trauma-what-are-the-leading-opinions
#19
L Grünherz, K O Jensen, V Neuhaus, L Mica, C M L Werner, B Ciritsis, C Michelitsch, G Osterhoff, H-P Simmen, K Sprengel
PURPOSE: The initial assessment of severely injured patients in the resuscitation room requires a systematic and quickly performed survey. Whereas the Advanced Trauma Life Support (ATLS(®))-based algorithm recommends focused assessment with sonography in trauma (FAST) among others, recent studies report a survival advantage of early whole-body computed tomography (WBCT) in haemodynamically stable as well as unstable patients. This study assessed the opinions of trauma surgeons about the early use of WBCT in severely injured patients with abdominal trauma, and abdominal CT in patients with isolated abdominal trauma, during resuscitation room treatment...
July 20, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28728044/atomic-force-microscopy-study-of-morphological-modifications-induced-by-different-decontamination-treatments-on-escherichia-coli
#20
Florina Lucica Zorila, Cristina Ionescu, Liviu Stefan Craciun, Bogdan Zorila
In this paper we used atomic force microscopy (AFM) to investigate the surface morphology of Escherichia coli, after being subjected to decontamination treatments, at sub-MICs levels (minimal inhibitory concentrations), with different disinfectants used in hospitals, pharmaceutical, food industry and even in our home, as an essential means to prevent the spreading of microorganisms. This article focuses on different morphological modifications adopted by E. coli cells as responses to the different modes of action of these substances...
July 14, 2017: Ultramicroscopy
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