Andrew D Bretherick, Simon J McGrath, Andy Devereux-Cooke, Sian Leary, Emma Northwood, Anna Redshaw, Pippa Stacey, Claire Tripp, Jim Wilson, Sonya Chowdhury, Isabel Lewis, Øyvind Almelid, Sumy V Baby, Tom Baker, Hannes Becher, Thibaud Boutin, Malgorzata Clyde, Diana Garcia, John Ireland, Shona M Kerr, Ewan McDowall, David Perry, Gemma L Samms, Veronique Vitart, Jareth C Wolfe, Chris P Ponting
BACKGROUND: People with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) experience core symptoms of post-exertional malaise, unrefreshing sleep, and cognitive impairment. Despite numbering 0.2-0.4% of the population, no laboratory test is available for their diagnosis, no effective therapy exists for their treatment, and no scientific breakthrough regarding pathogenesis has been made. It remains unknown, despite decades of small-scale studies, whether individuals experience different types of ME/CFS separated by onset-type, sex or age...
2023: NIHR Open Res