Ellen M McDonagh, Gosia Trynka, Mark McCarthy, Emily Rose Holzinger, Shameer Khader, Nikolina Nakic, Xinli Hu, Helena Cornu, Ian Dunham, David Hulcoop
Open Targets, a consortium among academic and industry partners, focuses on using human genetics and genomics to provide insights to key questions that build therapeutic hypotheses. Large-scale experiments generate foundational data, and open-source informatic platforms systematically integrate evidence for target-disease relationships and provide dynamic tooling for target prioritization. A locus-to-gene machine learning model uses evidence from genome-wide association studies (GWAS Catalog, UK BioBank, and FinnGen), functional genomic studies, epigenetic studies, and variant effect prediction to predict potential drug targets for complex diseases...
April 12, 2024: Annual review of biomedical data science