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https://www.readbyqxmd.com/read/29667705/intellectual-disability-in-cerebral-palsy-a-population-based-retrospective-study
#1
Susan M Reid, Elaine M Meehan, Sarah J Arnup, Dinah S Reddihough
AIM: A population-based observational study design was used to describe the epidemiology of intellectual disability in cerebral palsy (CP) in terms of clinical and neuroimaging associations, and to report the impact of intellectual disability on utilization of health services and length of survival. METHOD: Population CP registry data were used to retrospectively assess the frequency of intellectual disability and strength of associations between intellectual disability and mobility, epilepsy, vision, hearing, communication, and neuroimaging patterns (n=1141)...
April 18, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29667217/secondary-prostate-cancer-screening-outcomes-by-race-in-the-prostate-lung-colorectal-and-ovarian-plco-screening-trial
#2
Eric A Miller, Paul F Pinsky, Amanda Black, Gerald L Andriole, Dudith Pierre-Victor
BACKGROUND: Despite disparities in prostate cancer incidence and mortality rates between black and white men, there is still insufficient data available to assess potential differences in the benefits and harms of prostate cancer screening by race. Although the Prostate, Lung, Colorectal, and Ovarian (PLCO) Screening Trial is underpowered to detect a difference by race in prostate-cancer specific mortality, because of the large study size, there are still sufficient numbers to examine secondary screening outcomes...
April 17, 2018: Prostate
https://www.readbyqxmd.com/read/29667039/perception-of-time-to-contact-of-slow-and-fast-moving-objects-using-monocular-and-binocular-motion-information
#3
Aaron J Fath, Mats Lind, Geoffrey P Bingham
The role of the monocular-flow-based optical variable τ in the perception of the time to contact of approaching objects has been well-studied. There are additional contributions from binocular sources of information, such as changes in disparity over time (CDOT), but these are less understood. We conducted an experiment to determine whether an object's velocity affects which source is most effective for perceiving time to contact. We presented participants with stimuli that simulated two approaching squares...
April 17, 2018: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29666758/-rhinochelys-amaberti-moret-1935-a-protostegid-turtle-from-the-early-cretaceous-of-france
#4
Isaure Scavezzoni, Valentin Fischer
Modern marine turtles (chelonioids) are the remnants of an ancient radiation that roots in the Cretaceous. The oldest members of that radiation are first recorded from the Early Cretaceous and a series of species are known from the Albian-Cenomanian interval, many of which have been allocated to the widespread but poorly defined genus Rhinochelys , possibly concealing the diversity and the evolution of early marine turtles. In order to better understand the radiation of chelonioids, we redescribe the holotype and assess the taxonomy of Rhinochelys amaberti Moret (1935) (UJF-ID...
2018: PeerJ
https://www.readbyqxmd.com/read/29666698/prevalence-of-intestinal-parasites-and-associated-factors-among-pulmonary-tuberculosis-suspected-patients-attending-university-of-gondar-hospital-gondar-northwest-ethiopia
#5
Yalewayker Tegegne, Tadelo Wondmagegn, Ligabaw Worku, Ayalew Jejaw Zeleke
Introduction: Intestinal parasitic infections are among the major public health problems in developing countries. Hence, it is significant to explore coinfection with intestinal parasites and pulmonary tuberculosis because coinfection increases the complexity of control and prevention of pulmonary tuberculosis and parasitic diseases. Objective: To assess the prevalence of intestinal parasites among pulmonary tuberculosis suspected patients. Method: Institutional based cross-sectional study was conducted at University of Gondar Hospital from March to May, 2017...
2018: Journal of Parasitology Research
https://www.readbyqxmd.com/read/29666440/analysis-of-dna-methylation-in-cancer-location-revisited
#6
REVIEW
Alexander Koch, Sophie C Joosten, Zheng Feng, Tim C de Ruijter, Muriel X Draht, Veerle Melotte, Kim M Smits, Jurgen Veeck, James G Herman, Leander Van Neste, Wim Van Criekinge, Tim De Meyer, Manon van Engeland
Changes in DNA methylation in cancer have been heralded as promising targets for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite the existence of more than 14,000 scientific publications describing DNA methylation-based biomarkers and their clinical associations in cancer, only 14 of these biomarkers have been translated into a commercially available clinical test. Methodological and experimental obstacles are both major causes of this disparity, but the genomic location of a DNA methylation-based biomarker is an intrinsic and essential property that also has an important and often overlooked role...
April 17, 2018: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29666277/disparate-binding-kinetics-by-an-intrinsically-disordered-domain-enables-temporal-regulation-of-transcriptional-complex-formation
#7
Neil O Robertson, Ngaio C Smith, Athina Manakas, Mahiar Mahjoub, Gordon McDonald, Ann H Kwan, Jacqueline M Matthews
Intrinsically disordered regions are highly represented among mammalian transcription factors, where they often contribute to the formation of multiprotein complexes that regulate gene expression. An example of this occurs with LIM-homeodomain (LIM-HD) proteins in the developing spinal cord. The LIM-HD protein LHX3 and the LIM-HD cofactor LDB1 form a binary complex that gives rise to interneurons, whereas in adjacent cell populations, LHX3 and LDB1 form a rearranged ternary complex with the LIM-HD protein ISL1, resulting in motor neurons...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666042/relationship-between-evidence-requirements-user-expectations-and-actual-experiences-usability-evaluation-of-the-twazon-arabic-weight-loss-app
#8
Aroub Alnasser, Janet Kyle, Abdulrahman Alkhalifah, Debbi Marais
BACKGROUND: Saudi Arabia has faced a steady growth in the prevalence of obesity. The concurrent and ubiquitous use of mobile technology, such as smartphones and apps, provides an opportunity for the implementation of mHealth technology, a method for delivering behavioral interventions. Despite their effectiveness in promoting lifestyle and diet modification, culturally adapted weight loss apps and related interventions are lacking in Gulf Cooperation Council countries. OBJECTIVE: The objective of our study was to identify the relationship between adherence to evidence-informed practices, potential user expectations, and actual user experiences in order to enhance the understanding of the overall usability of the Twazon Arabic weight loss app...
April 17, 2018: JMIR Human Factors
https://www.readbyqxmd.com/read/29666034/contraceptive-use-effectiveness-and-pregnancy-prevention-information-preferences-among-heterosexual-and-sexual-minority-college-women
#9
Heather D Blunt-Vinti, Erika L Thompson, Stacey B Griner
BACKGROUND: Previous research shows that sexual minority women have higher rates of unintended pregnancy than heterosexual women, but has not considered the wide range of contraceptive method effectiveness when exploring this disparity. We examine contraceptive use effectiveness and desire for pregnancy prevention information among college women across sexual orientation identity as a risk factor for unintended pregnancy. METHODS: Using the National College Health Assessment Fall-2015 dataset, restricted to women who reported engaging in vaginal sex and not wanting to be pregnant (N = 6,486), logistic regression models estimated the odds of contraceptive method effectiveness and desire for pregnancy prevention information by sexual orientation...
April 14, 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29666024/social-determinants-of-self-reported-health-for-canada-s-indigenous-peoples-a-public-health-approach
#10
R Bethune, N Absher, M Obiagwu, T Qarmout, M Steeves, M Yaghoubi, R Tikoo, M Szafron, C Dell, M Farag
OBJECTIVE: In Canada, indigenous peoples suffer from a multitude of health disparities. To better understand these disparities, this study aims to examine the social determinants of self-reported health for indigenous peoples in Canada. STUDY DESIGN: This study uses data from Statistics Canada's Aboriginal Peoples Survey 2012. METHODS: Multinomial logistic regression models were used to examine how selected social determinants of health are associated with self-reported health among off-reserve First Nations and Métis peoples in Canada...
April 14, 2018: Public Health
https://www.readbyqxmd.com/read/29665751/residential-mobility-and-cognitive-function-among-middle-aged-and-older-adults-in-china
#11
Hanzhang Xu, Matthew E Dupre, Truls Østbye, Allison A Vorderstrasse, Bei Wu
OBJECTIVES: To assess the association between rural and urban residential mobility and cognitive function among middle-aged and older adults in China. METHOD: We used data from the World Health Organization Study on global AGEing and adult health that included adults age 50+ from China ( N = 12,410). We used multivariate linear regressions to examine how residential mobility and age at migration were associated with cognitive function. RESULTS: Urban and urban-to-urban residents had the highest level of cognitive function, whereas rural and rural-to-rural residents had the poorest cognitive function...
January 1, 2018: Research on Aging
https://www.readbyqxmd.com/read/29665703/culturally-safe-health-initiatives-for-indigenous-peoples-in-canada-a-scoping-review
#12
Lauren Brooks-Cleator, Breanna Phillipps, Audrey Giles
Background Cultural safety has the potential to improve the health disparities between Indigenous and non-Indigenous Canadians, yet practical applications of the concept are lacking in the literature. Purpose This study aims to identify the key components of culturally safe health initiatives for the Indigenous population of Canada to refine its application in health-care settings. Methods We conducted a scoping review of the literature pertaining to culturally safe health promotion programs, initiatives, services, or care for the Indigenous population in Canada...
January 1, 2018: Canadian Journal of Nursing Research, Revue Canadienne de Recherche en Sciences Infirmières
https://www.readbyqxmd.com/read/29665231/estrogen-returns-to-the-stage-in-melanoma
#13
Jennifer L McQuade, Michael A Davies
It has long been recognized that female sex is associated with a lower risk of and improved survival in melanoma (Joosse et al., 2012). However, the mechanism underlying this disparity in outcomes is not understood. One potential explanation is behavioral- i.e. differences by sex in UV exposure, screening and detection, and healthcare utilization. Observed differences between men and women in prognostic factors in primary melanomas would support this. For example, men are more likely to have thicker, ulcerated tumors, which could reflect diagnostic delays...
April 17, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29664975/estimation-of-unobservable-selection-effects-in-on-line-surveys-through-propensity-score-matching-an-application-to-public-acceptance-of-healthy-eating-policies
#14
Sara Capacci, Mario Mazzocchi, Sergio Brasini
The use of model-based propensity scores as matching tools opens the way to the indirect estimation of mode-related measurement effects and selection effects in web surveys, including a component of selection that cannot be traced back to observable characteristics. By matching and comparing respondents from real independent surveys that use the same questionnaire, but different administration modes, it becomes possible to isolate the selection effect induced by unobservable (or unobserved) respondent characteristics...
2018: PloS One
https://www.readbyqxmd.com/read/29664635/ultrafast-through-space-electronic-energy-transfer-in-molecular-dyads-built-around-dynamic-spacer-units
#15
Raymond Ziessel, Patrycja Stachelek, Anthony Harriman, Gordon J Hedley, Thomas J Roland, Arvydas Ruseckas, Ifor David William Samuel
A pair of complimentary molecular dyads have been synthesized around a 1,2-diaminocyclohexyl spacer that itself undergoes ring inversion. Despite these conformational exchange processes, the donor and acceptor occupy quite restricted spatial regions and they are not interchangeable. The donor and acceptor pair comprise disparate boron dipyrromethene dyes selected to display favorable electronic energy transfer (EET). Steady-state emission spectroscopy con-firms that through-space EET from donor to acceptor is almost quantitative, aided by the relatively short separations...
April 17, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29664403/socioeconomic-disparities-in-adherence-and-outcomes-after-heart-transplant-a-unos-united-network-for-organ-sharing-registry-analysis
#16
Brian Wayda, Autumn Clemons, Raymond C Givens, Koji Takeda, Hiroo Takayama, Farhana Latif, Susan Restaino, Yoshifumi Naka, Maryjane A Farr, Paolo C Colombo, Veli K Topkara
BACKGROUND: There is mixed evidence of racial and socioeconomic disparities in heart transplant outcomes. Their underlying cause-and whether individual- or community-level traits are most influential-remains unclear. The current study aimed to characterize socioeconomic disparities in outcomes and identify time trends and mediators of these disparities. METHODS AND RESULTS: We used United Network for Organ Sharing registry data and included 33 893 adult heart transplant recipients between 1994 and 2014...
March 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29664388/epidemic-dynamics-of-vibrio-parahaemolyticus-illness-in-a-hotspot-of-disease-emergence-galicia-spain
#17
Jaime Martinez-Urtaza, Joaquin Trinanes, Michel Abanto, Antonio Lozano-Leon, Jose Llovo-Taboada, Marta Garcia-Campello, Anxela Pousa, Andy Powell, Craig Baker-Austin, Narjol Gonzalez-Escalona
Galicia in northwestern Spain has been considered a hotspot for Vibrio parahaemolyticus infections. Infections abruptly emerged in 1998 and, over the next 15 years, were associated with large outbreaks caused by strains belonging to a single clone. We report a recent transition in the epidemiologic pattern in which cases throughout the region have been linked to different and unrelated strains. Global genome-wide phylogenetic analysis revealed that most of the pathogenic strains isolated from infections were associated with globally diverse isolates, indicating frequent episodic introductions from disparate and remote sources...
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29663981/health-behaviors-among-low-income-hispanic-and-non-hispanic-white-women
#18
Donna M Winham, Shelly M Palmer, Traci L Armstrong Florian, Mack C Shelley
OBJECTIVES: We determined relationships between food behaviors and health-risk factors by acculturation among limited-income Hispanic and non-Hispanic white women. METHODS: Women aged 18-49 years were recruited from income-based programs in metro-Phoenix, Arizona. Self-administered surveys in English or Spanish included demographics, a 10-item food behavior checklist, health-risk factors, food security, and acculturation. Differences by 4 acculturation/ethnicity categories were assessed with chi-square and analysis of variance (ANOVA)...
May 1, 2018: American Journal of Health Behavior
https://www.readbyqxmd.com/read/29663862/dynamics-and-structural-stability-effects-of-germline-pten-mutations-associated-with-cancer-versus-autism-phenotypes
#19
Iris Nira Smith, Stetson Thacker, Ritika Jaini, Charis Eng
Individuals with germline mutations in the tumor suppressor gene phosphatase and tensin homolog (PTEN), irrespective of clinical presentation, are diagnosed with PTEN hamartoma tumor syndrome (PHTS). PHTS confers a high risk of breast, thyroid, and other cancers or autism spectrum disorder (ASD) with macrocephaly. It remains unclear why mutations in one gene can lead to seemingly disparate phenotypes. Thus, we sought to identify differences in ASD vs. cancer-associated germline PTEN missense mutations by investigating putative structural effects induced by each mutation...
April 17, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29663552/sex-differences-in-the-drivers-of-reproductive-skew-in-a-cooperative-breeder
#20
Martha J Nelson-Flower, Tom P Flower, Amanda R Ridley
Many cooperatively breeding societies are characterized by high reproductive skew, such that some socially dominant individuals breed, while socially subordinate individuals provide help. Inbreeding avoidance serves as a source of reproductive skew in many high-skew societies, but few empirical studies have examined sources of skew operating alongside inbreeding avoidance, or compared individual attempts to reproduce (reproductive competition) with individual reproductive success. Here we use long-term genetic and observational data to examine factors affecting reproductive skew in the high-skew cooperatively breeding southern pied babbler (Turdoides bicolor)...
April 16, 2018: Molecular Ecology
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