keyword
https://read.qxmd.com/read/37936690/astrogliosis-in-multiple-sclerosis-and-neuro-inflammation-what-role-for-the-notch-pathway
#21
REVIEW
Pierre Mora, Candice Chapouly
Multiple sclerosis is an autoimmune inflammatory disease of the central nervous system leading to neurodegeneration. It affects 2.3 million people worldwide, generally younger than 50. There is no known cure for the disease, and current treatment options - mainly immunotherapies to limit disease progression - are few and associated with serious side effects. In multiple sclerosis, disruption of the blood-brain barrier is an early event in the pathogenesis of lesions, predisposing to edema, excito-toxicity and inflammatory infiltration into the central nervous system...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37936169/gateway-reflexes-describe-novel-neuro-immune-communications-that-establish-immune-cell-gateways-at-specific-vessels
#22
REVIEW
Hiroki Tanaka, Rie Hasebe, Kaoru Murakami, Toshiki Sugawara, Takeshi Yamasaki, Masaaki Murakami
Neuroinflammation is an important biological process induced by complex interactions between immune cells and neuronal cells in the central nervous system (CNS). Recent research on the bidirectional communication between neuronal and immunological systems has provided evidence for how immune and inflammatory processes are regulated by nerve activation. One example is the gateway reflex, in which immune cells bypass the blood brain barrier and infiltrate the CNS to cause neuroinflammation. We have found several modes of the gateway reflex in mouse models, in which gateways for immune cells are established at specific blood vessels in the spinal cords and brain in experimental autoimmune encephalomyelitis and systemic lupus erythematosus models, at retinal blood vessels in an experimental autoimmune uveitis model, and the ankle joints in an inflammatory arthritis model...
November 8, 2023: Bioelectronic Medicine
https://read.qxmd.com/read/37905282/the-hook-effect-a-case-study-of-a-giant-invasive-prolactinoma-with-falsely-low-serum-prolactin
#23
Rafaela F Gonçalves, Marco Antônio S Vaz, Guilherme Rollin, Gustavo Rassier Isolan
Prolactinomas are benign pituitary tumors also known as prolactin-secreting adenomas (PSA). These tumors cause excessive secretion of prolactin (hyperprolactinemia), a hormone responsible for lactation. Diagnosing hyperprolactinemia relies on measuring prolactin levels in the blood, and elevated serum levels of prolactin are typically indicative of prolactinoma. The hook effect occurs in immunological tests such as the prolactin level test. When the amount of prolactin present in the sample is too high and exceeds the binding capacity of the antibodies being used, the test result may indicate falsely low levels of prolactin, which is the hook effect...
September 2023: Curēus
https://read.qxmd.com/read/37860265/methods-of-mirna-delivery-and-possibilities-of-their-application-in-neuro-oncology
#24
REVIEW
Ilgiz Gareev, Ozal Beylerli, Rasim Tamrazov, Tatiana Ilyasova, Alina Shumadalova, Weijie Du, Baofeng Yang
In the current phase of medical progress, practical neuro-oncology faces critical challenges. These include the quest for and development of innovative methodological approaches, as well as the enhancement of conventional therapies to boost their efficacy in treating brain tumors, especially the malignant varieties. Recent strides in molecular and cellular biology, molecular genetics, and immunology have charted the primary research pathways in the development of new anti-cancer medications, with a particular focus on microRNA (miRNA)-based therapy...
December 2023: Non-Coding RNA Research
https://read.qxmd.com/read/37841263/interleukin-6-at-the-interface-of-human-health-and-disease
#25
REVIEW
Elena Grebenciucova, Stephen VanHaerents
Interleukin 6 (IL-6) is a pleiotropic cytokine executing a diverse number of functions, ranging from its effects on acute phase reactant pathways, B and T lymphocytes, blood brain barrier permeability, synovial inflammation, hematopoiesis, and embryonic development. This cytokine empowers the transition between innate and adaptive immune responses and helps recruit macrophages and lymphocytes to the sites of injury or infection. Given that IL-6 is involved both in the immune homeostasis and pathogenesis of several autoimmune diseases, research into therapeutic modulation of IL-6 axis resulted in the approval of a number of effective treatments for several autoimmune disorders like neuromyelitis optica spectrum disorder (NMOSD), rheumatoid arthritis, juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, giant cell arteritis (GCA), and cytokine release syndrome, associated with SARS-CoV2 pneumonia...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37804756/from-mental-fog-to-post-acute-covid-19-syndrome-s-executive-function-alteration-implications-for-clinical-approach
#26
JOURNAL ARTICLE
Stefano Pallanti, Michele Di Ponzio, Gioele Gavazzi, Gregory Gasic, Bianca Besteher, Carina Heller, Ron Kikinis, Nikos Makris, Zora Kikinis
A common symptom of the neuropsychiatric Post-Acute COVID-19 syndrome (neuro-PACS) is the so called 'brain fog'. Patients describe the brain fog as problems with attention, memory and mental fatigue. Brain fog is experienced by 9-55% of people for months after having contracted SARS-CoV-2 virus. Several theories have been proposed to explain PACS's brain fog, including a neuroinflammatory hypothesis, but the hypothesis remains to be proven. Here, we examined inflammatory and immunological blood profile in a cohort of patients with PACS to investigate the association between executive functions and blood inflammatory markers...
September 30, 2023: Journal of Psychiatric Research
https://read.qxmd.com/read/37804656/over-expression-of-il-33-enhances-rabies-virus-early-antigen-presentations-and-cellular-immune-responses-in-mice
#27
JOURNAL ARTICLE
Lele Liu, Wenwen Zheng, Hua Qian, Zhongxin Zhao, Li Tian, Yanyan Song, Xiaoying Lei, Zhongpeng Zhao, Xianghong Xue, Xuexing Zheng
Human inactivated rabies virus (RABV) vaccines have been widely used worldwide over 30 years. The mechanisms of humoral immunity elicited by previously reported rabies candidate vaccines have been fully investigated, but little is known about the cellular immunity profiles. Herein, the recombinant RABV rLBNSE-IL-33 overexpressing the mouse interleukin-33 (IL-33) proliferated well in Neuro-2a cells and had no effects with the parent virus on growth kinetic in vitro and viral pathogenicity in mice. The rLBNSE-IL-33 experienced more antigen presentations by MHC-II on DCs and activated more CD4+ T cells which helped recruit more CD19+ CD40+ B cells in blood and promote rapid and robust IgG1 antibodies responses at initial infection stage compared with the parent rLBNSE strain...
October 5, 2023: International Immunopharmacology
https://read.qxmd.com/read/37801969/orexin-a-alleviates-lps-induced-acute-lung-injury-by-inhibiting-macrophage-activation-through-jnk-mediated-autophagy
#28
JOURNAL ARTICLE
Yunjuan Nie, Junjie Liang, Jie Sun, Jiao Li, Xiaorun Zhai, Peng Zhao
Crosstalk between the central nervous system and immune system by the neuroendocrine and autonomic nervous systems is critical during the inflammatory response. Exposure to endotoxin alters the activity of hypothalamic homeostatic systems, resulting in changed transmitter release within the brain. This study investigated the effects and cellular molecular mechanisms of neurogenic and exogenous orexin-A (OXA) in LPS-induced acute lung injury (ALI). We found the production of OXA in the hypothalamus and lungs was both decreased following LPS infection...
October 4, 2023: International Immunopharmacology
https://read.qxmd.com/read/37797598/how-can-experimental-endotoxemia-contribute-to-our-understanding-of-pain-a-narrative-review
#29
REVIEW
Sven Benson, Bianka Karshikoff
The immune system and the central nervous system exchange information continuously. This communication is a prerequisite for adaptive responses to physiological and psychological stressors. While the implicate relationship between inflammation and pain is increasingly recognized in clinical cohorts, the underlying mechanisms and the possibilities for pharmacological and psychological approaches aimed at neuro-immune communication in pain are not fully understood yet. This calls for preclinical models which build a bridge from clinical research to laboratory research...
2023: Neuroimmunomodulation
https://read.qxmd.com/read/37763150/immunological-biomarkers-as-predictors-of-treatment-response-in-psychotic-disorders
#30
REVIEW
Elif Bayram Orbe, Michael Eriksen Benros
Psychotic disorders, notably schizophrenia, impose a detrimental burden on both an individual and a societal level. The mechanisms leading to psychotic disorders are multifaceted, with genetics and environmental factors playing major roles. Increasing evidence additionally implicates neuro-inflammatory processes within at least a subgroup of patients with psychosis. While numerous studies have investigated anti-inflammatory add-on treatments to current antipsychotics, the exploration of immunological biomarkers as a predictor of treatment response remains limited...
September 15, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37758193/a-combinatory-vaccine-with-ima950-plus-varlilumab-promotes-effector-memory-t-cell-differentiation-in-the-peripheral-blood-of-patients-with-low-grade-gliomas
#31
RANDOMIZED CONTROLLED TRIAL
Atsuro Saijo, Hirokazu Ogino, Nicholas A Butowski, Meghan R Tedesco, David Gibson, Payal B Watchmaker, Kaori Okada, Albert S Wang, Anny Shai, Andres M Salazar, Annette M Molinaro, Jane E Rabbitt, Maryam Shahin, Arie Perry, Jennifer L Clarke, Jennie W Taylor, Mariza Daras, Nancy Ann Oberheim Bush, Shawn L Hervey-Jumper, Joanna J Phillips, Susan M Chang, Norbert Hilf, Andrea Mayer-Mokler, Tibor Keler, Mitchel S Berger, Hideho Okada
BACKGROUND: Central nervous system (CNS) WHO grade 2 low-grade glioma (LGG) patients are at high risk for recurrence and with unfavorable long-term prognosis due to the treatment resistance and malignant transformation to high-grade glioma. Considering the relatively intact systemic immunity and slow-growing nature, immunotherapy may offer an effective treatment option for LGG patients. METHODS: We conducted a prospective, randomized pilot study to evaluate the safety and immunological response of the multipeptide IMA950 vaccine with agonistic anti-CD27 antibody, varlilumab, in CNS WHO grade 2 LGG patients...
February 2, 2024: Neuro-oncology
https://read.qxmd.com/read/37758055/filaggrin-and-beyond-new-insights-into-the-skin-barrier-in-atopic-dermatitis-and-allergic-diseases-from-genetics-to-therapeutic-perspectives
#32
REVIEW
Nicholas Stefanovic, Alan D Irvine
Atopic dermatitis is the most common inflammatory skin disease worldwide, affecting 20% of children and 5% of adults. One critical component in the pathophysiology of atopic dermatitis is the epidermal skin barrier, with its outermost layer- the stratum corneum (SC) being conferring biochemical properties that enable resilience against environmental threats and maintain homeostasis. The skin barrier may be conceptualized as a key facilitator of complex interactions between genetics, host immunity, the cutaneous microbiome, and environmental exposures...
September 25, 2023: Annals of Allergy, Asthma & Immunology
https://read.qxmd.com/read/37755632/characterizing-t-cell-dysfunction-and-exclusion-signatures-in-malignant-peripheral-nerve-sheath-tumors-reveals-susceptibilities-to-immunotherapy
#33
JOURNAL ARTICLE
Archis R Bhandarkar, Shaan Bhandarkar, Dusica Babovic-Vuksanovic, Ian F Parney, Robert J Spinner
PURPOSE: Malignant peripheral nerve sheath tumors (MPNSTs) are malignant tumors that arise from peripheral nerves and are the leading cause of mortality in Neurofibromatosis Type 1 (NF1). In this study, we characterized whether transcriptomic signatures of T-cell dysfunction (TCD) and exclusion (TCE) that inversely correlate with response to immune checkpoint blockade (ICB) immunotherapy exist in MPNSTs. METHODS: MPNST transcriptomes were pooled from Gene Expression Omnibus (GEO)...
September 27, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/37742934/nasal-epithelial-gene-expression-and-total-ige-in-children-and-adolescents-with-asthma
#34
JOURNAL ARTICLE
Zhongli Xu, Erick Forno, Yidan Sun, Michelle Manni, Yueh Ying Han, Soyeon Kim, Molin Yue, Judith M Vonk, Elin T M Kersten, Edna Acosta-Perez, Glorisa Canino, Gerard H Koppelman, Wei Chen, Juan C Celedón
BACKGROUND: Little is known about nasal epithelial gene expression and total IgE in youth. METHODS: We conducted a transcriptome-wide association study (TWAS) of total IgE in 469 Puerto Ricans aged 9-20 years who participated in the Epigenetic Variation and Childhood Asthma in Puerto Rico (EVA-PR) study, separately in all subjects and in those with asthma. We then attempted to replicate top findings for each analysis using data from three cohorts. Genes with Benjamini-Hochberg (BH)-adjusted P <0...
September 22, 2023: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/37691955/brain-response-in-asthma-the-role-of-lung-brain-axis-mediated-by-neuroimmune-crosstalk
#35
REVIEW
Yao Wang, Ya-Kui Mou, Han-Rui Wang, Xiao-Yu Song, Shi-Zhuang Wei, Chao Ren, Xi-Cheng Song
In addition to typical respiratory symptoms, patients with asthma are frequently accompanied by cognitive decline, mood disorders (anxiety and depression), sleep disorders, olfactory disorders, and other brain response manifestations, all of which worsen asthma symptoms, form a vicious cycle, and exacerbate the burden on families and society. Therefore, studying the mechanism of neurological symptoms in patients with asthma is necessary to identify the appropriate preventative and therapeutic measures. In order to provide a comprehensive reference for related research, we compiled the pertinent literature, systematically summarized the latest research progress of asthma and its brain response, and attempted to reveal the possible "lung-brain" crosstalk mechanism and treatment methods at the onset of asthma, which will promote more related research to provide asthmatic patients with neurological symptoms new hope...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37691950/corrigendum-neuro-pasc-is-characterized-by-enhanced-cd4-and-diminished-cd8-t-cell-responses-to-sarscov-2-nucleocapsid-protein
#36
Lavanya Visvabharathy, Barbara A Hanson, Zachary S Orban, Patrick H Lim, Nicole M Palacio, Millenia Jimenez, Jeffrey R Clark, Edith L Graham, Eric M Liotta, George Tachas, Pablo Penaloza-MacMaster, Igor J Koralnik
[This corrects the article DOI: 10.3389/fimmu.2023.1155770.].
2023: Frontiers in Immunology
https://read.qxmd.com/read/37679810/transcriptional-immunogenomic-analysis-reveals-distinct-immunological-clusters-in-paediatric-nervous-system-tumours
#37
JOURNAL ARTICLE
Arash Nabbi, Pengbo Beck, Alberto Delaidelli, Derek A Oldridge, Sumedha Sudhaman, Kelsey Zhu, S Y Cindy Yang, David T Mulder, Jeffrey P Bruce, Joseph N Paulson, Pichai Raman, Yuankun Zhu, Adam C Resnick, Poul H Sorensen, Martin Sill, Sebastian Brabetz, Sander Lambo, David Malkin, Pascal D Johann, Marcel Kool, David T W Jones, Stefan M Pfister, Natalie Jäger, Trevor J Pugh
BACKGROUND: Cancer immunotherapies including immune checkpoint inhibitors and Chimeric Antigen Receptor (CAR) T-cell therapy have shown variable response rates in paediatric patients highlighting the need to establish robust biomarkers for patient selection. While the tumour microenvironment in adults has been widely studied to delineate determinants of immune response, the immune composition of paediatric solid tumours remains relatively uncharacterized calling for investigations to identify potential immune biomarkers...
September 7, 2023: Genome Medicine
https://read.qxmd.com/read/37673862/immune-landscape-and-redox-imbalance-during-neurological-disorders-in-covid-19
#38
REVIEW
Abhimanyu Thakur, Vartika Sharma, Sera Averbek, Lifan Liang, Nirali Pandya, Gaurav Kumar, Alma Cili, Kui Zhang
The outbreak of Coronavirus Disease 2019 (COVID-19) has prompted the scientific community to explore potential treatments or vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the illness. While SARS-CoV-2 is mostly considered a respiratory pathogen, several neurological complications have been reported, raising questions about how it may enter the Central Nervous System (CNS). Receptors such as ACE2, CD147, TMPRSS2, and NRP1 have been identified in brain cells and may be involved in facilitating SARS-CoV-2 entry into the CNS...
September 6, 2023: Cell Death & Disease
https://read.qxmd.com/read/37614230/neat1-lncrna-organizes-the-inflammatory-gene-expressions-in-the-dorsal-root-ganglion-in-neuropathic-pain-caused-by-nerve-injury
#39
JOURNAL ARTICLE
Motoyo Maruyama, Atsushi Sakai, Tsukasa Fukunaga, Yoshitaka Miyagawa, Takashi Okada, Michiaki Hamada, Hidenori Suzuki
Primary sensory neurons regulate inflammatory processes in innervated regions through neuro-immune communication. However, how their immune-modulating functions are regulated in concert remains largely unknown. Here, we show that Neat1 long non-coding RNA (lncRNA) organizes the proinflammatory gene expressions in the dorsal root ganglion (DRG) in chronic intractable neuropathic pain in rats. Neat1 was abundantly expressed in the DRG and was upregulated after peripheral nerve injury. Neat1 overexpression in primary sensory neurons caused mechanical and thermal hypersensitivity, whereas its knockdown alleviated neuropathic pain...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37612134/sars-cov-2-specific-immune-responses-in-patients-with-postviral-syndrome-after-suspected-covid-19
#40
JOURNAL ARTICLE
Zachary S Orban, Lavanya Visvabharathy, Gina S Perez Giraldo, Millenia Jimenez, Igor J Koralnik
BACKGROUND AND OBJECTIVES: Millions of Americans were exposed to SARS-CoV-2 early in the pandemic but could not get diagnosed with COVID-19 due to testing limitations. Many have developed a postviral syndrome (PVS) including neurologic manifestations similar to those with postacute sequelae of SARS-CoV-2 infection (Neuro-PASC). Owing to those circumstances, proof of SARS-CoV-2 infection was not required for evaluation at Northwestern Medicine's Neuro COVID-19 clinic. We sought to investigate clinical and immunologic findings suggestive of SARS-CoV-2 exposure in patients with PVS...
November 2023: Neurology® Neuroimmunology & Neuroinflammation
keyword
keyword
18449
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.