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Dendritic cell sarcoma

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https://www.readbyqxmd.com/read/28302385/primary-cutaneous-interdigitating-dendritic-cell-sarcoma-is-a-morphologic-and-phenotypic-simulator-of-poorly-differentiated-metastatic-melanoma-a-report-of-2-cases-and-review-of-the-literature
#1
REVIEW
Cynthia M Magro, Luke C Olson, Gerard Nuovo, Garron J Solomon
Interdigitating dendritic cell sarcoma (IDS) is a rare form of hematologic malignancy associated with an aggressive clinical course. Only 4 prior cases have been described as originating in the skin. We encountered two male patients ages 47 and 61years of age who presented with solitary cutaneous neoplasms diagnosed as IDS. Histologic exam showed a coalescing nested and multinodular proliferation of large pleomorphic epithelioid cells. In one case an initial diagnosis of melanoma was rendered. A recurrence 8months later was then interpreted as a primary cutaneous IDS...
February 20, 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28241093/phase-1-2-study-of-immunotherapy-with-dendritic-cells-pulsed-with-autologous-tumor-lysate-in-patients-with-refractory-bone-and-soft-tissue-sarcoma
#2
Shinji Miwa, Hideji Nishida, Yoshikazu Tanzawa, Akihiko Takeuchi, Katsuhiro Hayashi, Norio Yamamoto, Eishiro Mizukoshi, Yasunari Nakamoto, Shuichi Kaneko, Hiroyuki Tsuchiya
BACKGROUND: There are limited options for the curative treatment of refractory bone and soft tissue sarcomas. The purpose of this phase 1/2 study was to assess the immunological and clinical effects of dendritic cells (DCs) pulsed with autologous tumor lysate (TL) in patients with advanced bone and soft tissue sarcomas. METHODS: Thirty-seven patients with metastatic or recurrent sarcomas were enrolled in this study. Peripheral blood mononuclear cells obtained from the patients were suspended in media containing interleukin 4 (IL-4) and granulocyte-macrophage colony-stimulating factor...
February 27, 2017: Cancer
https://www.readbyqxmd.com/read/28197348/angioimmunoblastic-t-cell-lymphoma-a-questionable-association-with-follicular-dendritic-cell-sarcoma
#3
Daniel Benharroch, Miriam Zekzer, Karen Nalbandyan
An elderly woman presented with generalized lymphadenopathy, several systemic symptoms, and splenomegaly. An inguinal lymph node excision revealed a compound picture. One aspect of the lymph node morphology, including cells with follicular T-helper cell phenotype, was most consistent with angioimmunoblastic T-cell lymphoma. The other component, revealing spindle cells forming whorls with immunostaining for CD21, CD23, and fascin, might be an integral part of this T-cell lymphoma. However, due to the often massive involvement of the nodal tissue by these follicular dendritic cells, these areas were questionably suggestive of involvement by follicular dendritic cell sarcoma...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28178429/variations-in-histiocytic-differentiation-of-cell-lines-from-canine-cerebral-and-articular-histiocytic-sarcomas
#4
A Thongtharb, K Uchida, J K Chambers, H Nakayama
Two newly established canine histiocytic sarcoma (HS) cell lines, designated as PWC-HS01 and FCR-HS02, were obtained from brain and articular tumors, respectively. These 2 HS cell lines had phagocytic ability and modal chromosome aberrations. Although morphologic features of both HS cells were similar, immunocytochemical examinations revealed that the PWC-HS01 cell line expressed both dendritic cell (ie, S100, CD208, CD1, and CD4) and macrophage (ie, CD68, CD163, and CD204) markers. In contrast, the FCR-HS02 cell line was immunonegative for CD204 and CD68 but consistently positive for the dendritic cell markers...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28160447/-medusa-head-cells-starfish-cells-and-interconnecting-long-cytoplasmic-processes-as-diagnostic-cytologic-clues-for-follicular-dendritic-cell-sarcoma-in-fine-needle-aspiration-samples
#5
Agata Czapla, Reeba A Omman, Moon Woo Nam, Swati Mehrotra, Stefan E Pambuccian
No abstract text is available yet for this article.
April 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28145886/identification-of-novel-follicular-dendritic-cell-sarcoma-markers-fdcsp-and-srgn-by-whole-transcriptome-sequencing
#6
Luisa Lorenzi, Claudia Döring, Tobias Rausch, Vladimir Benes, Silvia Lonardi, Mattia Bugatti, Elias Campo, José Cabeçadas, Ingrid Simonitsch-Klupp, Anita Borges, Jay Mehta, Claudio Agostinelli, Stefano Aldo Pileri, Fabio Facchetti, Martin-Leo Hansmann, Sylvia Hartmann
Follicular dendritic cell (FDC)-sarcoma is a rare neoplasm with morphologic and phenotypic features of FDCs. It shows an extremely heterogeneous morphology, therefore, its diagnosis relys on the phenotype of tumor cells. Aim of the present study was the identification of new specific markers for FDC-sarcoma by whole transcriptome sequencing (WTS). Candidate markers were selected based on gene expression level and biological function. Immunohistochemistry was performed on reactive tonsils, on 22 cases of FDC-sarcomas and 214 control cases including 114 carcinomas, 87 soft tissue tumors, 5 melanomas, 5 thymomas and 3 interdigitating dendritic cell sarcomas...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28130401/distinctive-histogenesis-and-immunological-microenvironment-based-on-transcriptional-profiles-of-follicular-dendritic-cell-sarcomas
#7
Maria Antonella Laginestra, Claudio Tripodo, Claudio Agostinelli, Giovanna Motta, Sylvia Hartmann, Claudia Doring, Maura Rossi, Federica Melle, Maria Rosaria Sapienza, Valentina Tabanelli, Alessandro Pileri, Fabio Fuligni, Anna Gazzola, Claudia Mannu, Carlo Alberto Sagramoso, Silvia Lonardi, Luisa Lorenzi, Francesco Bacci, Elena Sabattini, Anita Borges, Ingrid Simonitsch-Klupp, Jose Cabecadas, Elias Campo, Juan Rosai, Martin-Leo Hansmann, Fabio Facchetti, Stefano Aldo Pileri
Follicular dendritic cell (FDC) sarcomas are rare mesenchymal tumors (MTs) with variable clinical, morphologic and phenotypic characteristics. Transcriptome analysis was performed on multiple FDC sarcomas and compared to other MTs, microdissected Castleman FDCs, and normal fibroblasts. Using unsupervised analysis, FDC sarcomas clustered with microdissected FDCs, distinct from other MTs and fibroblasts. The specific endowment of FDC-related gene expression programs in FDC sarcomas emerged by applying a gene signature of differentially expressed genes (n=1,289) between microdissected FDCs and fibroblasts...
January 27, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28024116/mulberry-cells-in-the-thyroid-warthin-finkeldey-like-cells-in-hashimoto-thyroiditis-associated-lymphoma
#8
Razvan Lapadat, Moon Woo Nam, Swati Mehrotra, Milind Velankar, Stefan E Pambuccian
Warthin-Finkeldey type giant cells were first described in autopsies performed on young children who died during the highly lethal measles epidemic in Palermo during the winter of 1908. The cells had 8-15 nuclei without identifiable cytoplasm within the germinal centers of lymphoid organs resembling megakaryocytes. We describe a case of Hashimoto thyroiditis with an enlarging substernal throid mass. The resection specimen contained many Warthin-Finkeldey-Like Cells (WFLC) in an extranodal marginal zone lymphoma (MALT type) with focal transformation to diffuse large B-cell lymphoma...
March 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27862216/synchronous-presentation-of-intra-nodal-follicular-dendritic-cell-sarcoma-and-castleman-disease
#9
Preetesh Jain, Victor G Prieto, John T Manning, Nathan Fowler, L Jeffrey Medeiros, Rashmi Kanagal-Shamanna
No abstract text is available yet for this article.
November 8, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27823979/high-frequency-of-clonal-ig-and-t-cell-receptor-gene-rearrangements-in-histiocytic-and-dendritic-cell-neoplasms
#10
Wenting Huang, Tian Qiu, Linshu Zeng, Bo Zheng, Jianming Ying, Xiaoli Feng
The 2008 World Health Organization (WHO) diagnostic criteria of histiocytic and dendritic cell neoplasms from hematopoietic and lymphoid tissues no longer required the absence of clonal B-cell/T-cell receptor gene rearrangements. It is true that the clonal B-cell/T-cell receptor gene rearrangements have been identified in rare cases of histiocytic and dendritic cell neoplasms, such as those with or following lymphoma/leukemia or in some sporadic histiocytic/dendritic cell sarcomas, but the clonal features of such group of tumor are still not clear...
November 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27817254/cytohistological-and-immunohistochemical-characteristics-of-spindle-shaped-mesenchymal-neoplasms-occurring-in-the-gastrointestinal-tract
#11
Antonio Ieni, Valeria Barresi, Luca Reggiani Bonetti, Giovanni Branca, Rosario Alberto Caruso, Giovanni Tuccari
The purpose of the present review is to analyze the cytohistological and immunohistochemical characteristics of spindle-shaped mesenchymal gastrointestinal neoplams (MGNs), a group of unusual neoplastic conditions with different biological behavior. These tumors exhibit clinical pictures strictly related to the site of origin and dimensions, even if they appear generally with an intramural localization. This latter point may suggest an useful application of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), mainly followed by the cell-block procedure (CBP) in the differential diagnostic approach...
March 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27801729/richter-syndrome-with-plasmablastic-lymphoma-at-primary-diagnosis-a-case-report-with-a-review-of-the-literature
#12
Andrea Ronchi, Laura Marra, Ferdinando Frigeri, Gerardo Botti, Renato Franco, Annarosaria De Chiara
Richter syndrome (RS) is considered as the rare development of an aggressive lymphoid malignancy in a preexisting small lymphocytic lymphoma/chronic lymphocytic leukemia. The most common aggressive lymphoma developing in this setting is diffuse large B-cell lymphoma, but classical Hodgkin lymphoma and other much rarer entities such as prolymphocytic lymphoma and dendritic cell sarcoma are also described, most frequently in the progression of the disease over time. A clonal relation between the 2 neoplastic proliferations can be frequently found, whereas clonally unrelated cases are commonly considered as independent tumors, probably due to a variable combination of multiple causes, responsible independently for the 2 neoplasms...
October 31, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27793634/-18-f-fdg-pet-ct-follow-up-of-follicular-dendritic-cell-sarcoma
#13
D Albano, G Bosio, F Bertagna
Follicular dendritic cell sarcoma (FDCS) is a rare lymphoid neoplasm which occurs mainly in lymph nodes, especially cervical and mediastinal; it can be difficult to diagnose and often is misdiagnosed. Its pathogenesis is still not clear, like its evolution. We report a case of 60-year-old woman with FDCS of left lateral cervical node followed for almost 10 years, after a left selective neck dissection, who underwent five (18)F-FDG PET/CT. This technique has proven to be an useful method for the management of this patient, mainly for the follow up, detection of relapse and therapy response evaluation...
October 25, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/27775241/cytological-features-of-inflammatory-pseudotumor-like-follicular-dendritic-cell-sarcoma-of-spleen-a-case-report
#14
Jen-Fan Hang, Lei-Chi Wang, Chiung-Ru Lai
Here, we present the first cytological report of a primary splenic inflammatory pseudotumor-like follicular dendritic cell sarcoma. The 57 year-old male was incidentally found with a 2.2 cm well-demarcated splenic nodule. A sonography guided fine needle aspiration of the lesion was performed. The cytologic smears revealed loosely cohesive fragments of oval to spindle cells in a background of prominent lymphoplasmacytic infiltration. The cells showed sparse chromatin, distinct nucleoli, syncytial cell borders, and occasional cytoplasmic processes...
March 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27734516/follicular-dendritic-cell-sarcoma-treated-with-a-variety-of-chemotherapy
#15
Masaoki Sasaki, Hiroaki Izumi, Takaaki Yokoyama, Motohiro Kojima, Ako Hosono
Follicular dendritic cell sarcoma (FDCS) is a very rare malignant tumor derived from follicular dendritic cells. Radical resection is the standard therapy for patients with local disease, but an optimal chemotherapy regimen has not been determined for unresectable disease. We report our experience of an FDCS patient with multiorgan involvement. In the present case, disease was only located in the pancreas initially and radical resection was performed. Multiple metastasis developed after the treatment and several factors that indicated a poor prognosis were observed...
October 13, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27715410/kshv-reduces-autophagy-in-thp-1-cells-and-in-differentiating-monocytes-by-decreasing-cast-calpastatin-and-atg5-expression
#16
R Santarelli, M Granato, G Pentassuglia, V Lacconi, M S Gilardini Montani, R Gonnella, M Tafani, M R Torrisi, A Faggioni, M Cirone
We have previously shown that Kaposi sarcoma-associated herpesvirus (KSHV) impairs monocyte differentiation into dendritic cells (DCs). Macroautophagy/autophagy has been reported to be essential in such a differentiating process. Here we extended these studies and found that the impairment of DC formation by KSHV occurs through autophagy inhibition. KSHV indeed reduces CAST (calpastatin) and consequently decreases ATG5 expression in both THP-1 monocytoid cells and primary monocytes. We unveiled a new mechanism put in place by KSHV to escape from immune control...
December 2016: Autophagy
https://www.readbyqxmd.com/read/27684838/uncommon-liver-tumors-case-report-and-literature-review
#17
REVIEW
Chia-Hung Wu, Nai-Chi Chiu, Yi-Chen Yeh, Yu Kuo, Sz-Shian Yu, Ching-Yao Weng, Chien-An Liu, Yi-Hong Chou, Yi-You Chiou
BACKGROUND: Beside hepatocellular carcinoma, metastasis, and cholangiocarcinoma, the imaging findings of other relatively uncommon hepatic lesions are less discussed in the literature. Imaging diagnosis of these lesions is a daily challenge. In this article, we review the imaging characteristics of these neoplasms. METHODS: From January 2003 to December 2014, 4746 patients underwent liver biopsy or hepatic surgical resection in our hospital. We reviewed the pathological database retrospectively...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27680605/oncogene-status-of-an-interdigitating-dendritic-cell-sarcoma-recurrent-mutations-in-nf1-tp53-and-arid2-shared-with-melanoma
#18
Uwe Hillen, Florian Grabellus, Cindy Franklin, Antje Sucker, Dirk Schadendorf, Bastian Schilling
No abstract text is available yet for this article.
December 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27672780/poster-10-successful-rehabilitation-outcome-from-rare-brain-tumor-intracranial-follicular-dendritic-cell-sarcoma-a-case-report
#19
Brian W Lee, Steve A Sparr, Grigory Syrkin
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27646901/-extranodal-follicular-dendritic-cell-sarcoma-of-nasopharynx-report-of-a-case
#20
L Guo, Y B Zou, L L Tong, L R Bi
No abstract text is available yet for this article.
September 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
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