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Dendritic cell sarcoma

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https://www.readbyqxmd.com/read/27862216/synchronous-presentation-of-intra-nodal-follicular-dendritic-cell-sarcoma-and-castleman-disease
#1
Preetesh Jain, Victor G Prieto, John T Manning, Nathan Fowler, L Jeffrey Medeiros, Rashmi Kanagal-Shamanna
No abstract text is available yet for this article.
November 8, 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27823979/high-frequency-of-clonal-ig-and-t-cell-receptor-gene-rearrangements-in-histiocytic-and-dendritic-cell-neoplasms
#2
Wenting Huang, Tian Qiu, Linshu Zeng, Bo Zheng, Jianming Ying, Xiaoli Feng
The 2008 World Health Organization (WHO) diagnostic criteria of histiocytic and dendritic cell neoplasms from hematopoietic and lymphoid tissues no longer required the absence of clonal B-cell/T-cell receptor gene rearrangements. It is true that the clonal B-cell/T-cell receptor gene rearrangements have been identified in rare cases of histiocytic and dendritic cell neoplasms, such as those with or following lymphoma/leukemia or in some sporadic histiocytic/dendritic cell sarcomas, but the clonal features of such group of tumor are still not clear...
November 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27817254/cytohistological-and-immunohistochemical-characteristics-of-spindle-shaped-mesenchymal-neoplasms-occurring-in-the-gastrointestinal-tract
#3
Antonio Ieni, Valeria Barresi, Luca Reggiani Bonetti, Giovanni Branca, Rosario Alberto Caruso, Giovanni Tuccari
The purpose of the present review is to analyze the cytohistological and immunohistochemical characteristics of spindle-shaped mesenchymal gastrointestinal neoplams (MGNs), a group of unusual neoplastic conditions with different biological behavior. These tumors exhibit clinical pictures strictly related to the site of origin and dimensions, even if they appear generally with an intramural localization. This latter point may suggest an useful application of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), mainly followed by the cell-block procedure (CBP) in the differential diagnostic approach...
November 6, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27801729/richter-syndrome-with-plasmablastic-lymphoma-at-primary-diagnosis-a-case-report-with-a-review-of-the-literature
#4
Andrea Ronchi, Laura Marra, Ferdinando Frigeri, Gerardo Botti, Renato Franco, Annarosaria De Chiara
Richter syndrome (RS) is considered as the rare development of an aggressive lymphoid malignancy in a preexisting small lymphocytic lymphoma/chronic lymphocytic leukemia. The most common aggressive lymphoma developing in this setting is diffuse large B-cell lymphoma, but classical Hodgkin lymphoma and other much rarer entities such as prolymphocytic lymphoma and dendritic cell sarcoma are also described, most frequently in the progression of the disease over time. A clonal relation between the 2 neoplastic proliferations can be frequently found, whereas clonally unrelated cases are commonly considered as independent tumors, probably due to a variable combination of multiple causes, responsible independently for the 2 neoplasms...
October 31, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27793634/-18-f-fdg-pet-ct-follow-up-of-follicular-dendritic-cell-sarcoma
#5
D Albano, G Bosio, F Bertagna
Follicular dendritic cell sarcoma (FDCS) is a rare lymphoid neoplasm which occurs mainly in lymph nodes, especially cervical and mediastinal; it can be difficult to diagnose and often is misdiagnosed. Its pathogenesis is still not clear, like its evolution. We report a case of 60-year-old woman with FDCS of left lateral cervical node followed for almost 10 years, after a left selective neck dissection, who underwent five (18)F-FDG PET/CT. This technique has proven to be an useful method for the management of this patient, mainly for the follow up, detection of relapse and therapy response evaluation...
October 25, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/27775241/cytological-features-of-inflammatory-pseudotumor-like-follicular-dendritic-cell-sarcoma-of-spleen-a-case-report
#6
Jen-Fan Hang, Lei-Chi Wang, Chiung-Ru Lai
Here, we present the first cytological report of a primary splenic inflammatory pseudotumor-like follicular dendritic cell sarcoma. The 57 year-old male was incidentally found with a 2.2 cm well-demarcated splenic nodule. A sonography guided fine needle aspiration of the lesion was performed. The cytologic smears revealed loosely cohesive fragments of oval to spindle cells in a background of prominent lymphoplasmacytic infiltration. The cells showed sparse chromatin, distinct nucleoli, syncytial cell borders, and occasional cytoplasmic processes...
October 24, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27734516/follicular-dendritic-cell-sarcoma-treated-with-a-variety-of-chemotherapy
#7
Masaoki Sasaki, Hiroaki Izumi, Takaaki Yokoyama, Motohiro Kojima, Ako Hosono
Follicular dendritic cell sarcoma (FDCS) is a very rare malignant tumor derived from follicular dendritic cells. Radical resection is the standard therapy for patients with local disease, but an optimal chemotherapy regimen has not been determined for unresectable disease. We report our experience of an FDCS patient with multiorgan involvement. In the present case, disease was only located in the pancreas initially and radical resection was performed. Multiple metastasis developed after the treatment and several factors that indicated a poor prognosis were observed...
October 13, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27715410/kshv-reduces-autophagy-in-thp-1-cells-and-in-differentiating-monocytes-by-decreasing-cast-calpastatin-and-atg5-expression
#8
R Santarelli, M Granato, G Pentassuglia, V Lacconi, M S Gilardini Montani, R Gonnella, M Tafani, M R Torrisi, A Faggioni, M Cirone
We have previously shown that Kaposi sarcoma-associated herpesvirus (KSHV) impairs monocyte differentiation into dendritic cells (DCs). Macroautophagy/autophagy has been reported to be essential in such a differentiating process. Here we extended these studies and found that the impairment of DC formation by KSHV occurs through autophagy inhibition. KSHV indeed reduces CAST (calpastatin) and consequently decreases ATG5 expression in both THP-1 monocytoid cells and primary monocytes. We unveiled a new mechanism put in place by KSHV to escape from immune control...
October 7, 2016: Autophagy
https://www.readbyqxmd.com/read/27684838/uncommon-liver-tumors-case-report-and-literature-review
#9
Chia-Hung Wu, Nai-Chi Chiu, Yi-Chen Yeh, Yu Kuo, Sz-Shian Yu, Ching-Yao Weng, Chien-An Liu, Yi-Hong Chou, Yi-You Chiou
BACKGROUND: Beside hepatocellular carcinoma, metastasis, and cholangiocarcinoma, the imaging findings of other relatively uncommon hepatic lesions are less discussed in the literature. Imaging diagnosis of these lesions is a daily challenge. In this article, we review the imaging characteristics of these neoplasms. METHODS: From January 2003 to December 2014, 4746 patients underwent liver biopsy or hepatic surgical resection in our hospital. We reviewed the pathological database retrospectively...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27680605/oncogene-status-of-an-interdigitating-dendritic-cell-sarcoma-recurrent-mutations-in-nf1-tp53-and-arid2-shared-with-melanoma
#10
Uwe Hillen, Florian Grabellus, Cindy Franklin, Antje Sucker, Dirk Schadendorf, Bastian Schilling
No abstract text is available yet for this article.
September 27, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27672780/poster-10-successful-rehabilitation-outcome-from-rare-brain-tumor-intracranial-follicular-dendritic-cell-sarcoma-a-case-report
#11
Brian W Lee, Steve A Sparr, Grigory Syrkin
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27646901/-extranodal-follicular-dendritic-cell-sarcoma-of-nasopharynx-report-of-a-case
#12
L Guo, Y B Zou, L L Tong, L R Bi
No abstract text is available yet for this article.
September 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27603913/cancer-testis-antigens-expression-regulation-tumor-invasion-and-use-in-immunotherapy-of-cancers
#13
Arash Salmaninejad, Mohammad Reza Zamani, Mehrnaz Pourvahedi, Zahra Golchehre, Ali Hosseini Bereshneh, Nima Rezaei
UNLABELLED: Cancer/testis antigens (CTAs) are named based on their expression pattern that is restricted in a number of normal and abnormal tissues. Tumor cells frequently express antigens whose expression is typically restricted to germ cells. Their unique expression pattern is guaranteed by precise epigenetic regulatory mechanisms. Because of their tumor-limited, high immunogenicity, and biased expression, discovery of these molecules provides unprecedented opportunities for further research and clinical development in the field of cancer diagnosis and immunotherapy...
October 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27602139/follicular-dendritic-cell-sarcoma-of-the-spleen-a-case-report-and-review-of-the-literature
#14
Lifeng Wang, Dongfeng Xu, Zhenguo Qiao, Li Shen, Hongzhi Dai, Yiding Ji
Follicular dendritic cell sarcoma (FDCS), which originates in antigen-presenting cells of the B-cell follicles of the lymph nodes, is an uncommon disease, particularly in a splenic location. In a number of cases, FDCS may easily be confused with other solid tumors and be underdiagnosed. The present study reports a case in which such as tumor occurred in a 64-year-old woman. The patient presented with an abdominal mass, and computed tomography was performed. Histological and immunohistochemical studies revealed a diagnosis of FDCS...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27593552/dysplastic-follicular-dendritic-cells-in-hyaline-vascular-castleman-disease-a-rare-occurrence-creating-diagnostic-difficulty
#15
Edward A Medina, Neil E Fuehrer, Frank R Miller, Marsha C Kinney, Russell A Higgins
Follicular dendritic cell (FDC) proliferations and dysplastic FDCs can be seen in Hyaline-vascular Castleman disease (HVCD). The association between HVCD and FDC sarcoma is well-documented; dysplastic FDCs may be precursors to FDC sarcoma. Herein, we describe a case of HVCD with strikingly large and dysplastic FDCs, which raised the differential of Hodgkin lymphoma and other neoplasms. Scattered dysplastic FDCs were predominantly in germinal centers and mantle zones, and rarely in interfollicular areas. Although occasional germinal centers contained increased FDCs, no mass forming proliferations were present to suggest FDC sarcoma...
September 2016: Pathology International
https://www.readbyqxmd.com/read/27525088/paraneoplastic-pemphigus-and-myasthenia-gravis-associated-with-inflammatory-pseudotumor-like-follicular-dendritic-cell-sarcoma-response-to-rituximab
#16
Lifang Wang, Hui Deng, Mei Mao
Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease associated with neoplasms. The disease is most commonly of lymphoproliferative origin and presents high mortality. We describe a patient with PNP and myasthenia gravis associated with inflammatory pseudotumor-like follicular dendritic cell sarcoma, as well as the response to rituximab.
August 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27488020/treatment-of-breast-cancer-2-brca2-mutant-follicular-dendritic-cell-sarcoma-with-a-poly-adp-ribose-polymerase-parp-inhibitor-a-case-report
#17
Charlotte R Lemech, Rachel Williams, Stephen R Thompson, Brian McCaughan, Melvin Chin
BACKGROUND: Follicular dendritic cell sarcoma is a rare tumour with clinical behaviour covering a spectrum from indolent to aggressive disease. Treatment recommendations are currently based on case reports and small series describing combinations of surgery, chemotherapy and radiotherapy providing the best patient outcomes. Recent knowledge on molecular aberrations in this disease have not yet impacted on therapeutic decisions. CASE PRESENTATION: We describe a case of progressive follicular dendritic cell sarcoma of the lung and pleura, treated based on knowledge of the tumour's molecular aberrations...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/27471654/transgenic-antigen-specific-hla-a-02-01-allo-restricted-cytotoxic-t-cells-recognize-tumor-associated-target-antigen-steap1-with-high-specificity
#18
David Schirmer, Thomas G P Grünewald, Richard Klar, Oxana Schmidt, Dirk Wohlleber, Rebeca Alba Rubío, Wolfgang Uckert, Uwe Thiel, Felix Bohne, Dirk H Busch, Angela M Krackhardt, Stefan Burdach, Günther H S Richter
Pediatric cancers, including Ewing sarcoma (ES), are only weakly immunogenic and the tumor-patients' immune system often is devoid of effector T cells for tumor elimination. Based on expression profiling technology, targetable tumor-associated antigens (TAA) are identified and exploited for engineered T-cell therapy. Here, the specific recognition and lytic potential of transgenic allo-restricted CD8(+) T cells, directed against the ES-associated antigen 6-transmembrane epithelial antigen of the prostate 1 (STEAP1), was examined...
June 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27442049/primary-cutaneous-interdigitating-dendritic-cell-sarcoma-a-case-report-and-review-of-the-literature
#19
Catherine M Nguyen, David Cassarino
Interdigitating dendritic cell sarcoma (IDCS) is a rare tumor of spindle to ovoid cells intermixed with lymphocytes and plasma cells. Primary cutaneous IDCS, with no nodal or other organ involvement is extremely rare, with less than 10 cases reported to date. Herein, the authors describe a case in which a 61-year-old man presented with scattered subcutaneous nodules on his left shoulder and right anterior thigh. A biopsy was performed, and the histopathologic findings revealed prominent, diffuse superficial, and deep dermal infiltration by an atypical epithelioid-shaped tumor forming sheets and cords infiltrating throughout the dermis...
August 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27423414/mirna-expression-profiling-divides-follicular-dendritic-cell-sarcomas-into-two-groups-related-to-fibroblasts-and-myopericytomas-or-castleman-s-disease
#20
Sylvia Hartmann, Claudia Döring, Claudio Agostinelli, Soo-Jeong Portscher-Kim, Silvia Lonardi, Luisa Lorenzi, Fabio Fuligni, Daniel Martinez, Jay Mehta, Anita Borges, Holger Hackstein, Stefan Kippenberger, Pier Paolo Piccaluga, Ingrid Simonitsch-Klupp, José Cabeçadas, Elias Campo, Fabio Facchetti, Stefano A Pileri, Martin-Leo Hansmann
Follicular dendritic cell (FDC) sarcomas are rare mesenchymal tumours, which are fatal in 20% of the patients and usually occur in secondary lymphoid organs or extranodal localizations. Due to the rareness of these tumours, only few studies have been conducted on molecular level. In the present study, we performed microRNA (miRNA) profiling of 31 FDC sarcomas and identified two subgroups, one with high miRNA expression and the other group with low miRNA expression levels. The first group showed a strong similarity to fibroblasts and myopericytomas, whereas the second group was more closely related to FDCs from Castleman's disease...
September 2016: European Journal of Cancer
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