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https://www.readbyqxmd.com/read/27913274/two-grass-carp-ctenopharyngodon-idella-insulin-like-growth-factor-binding-protein-5-genes-exhibit-different-yet-conserved-functions-in-development-and-growth
#1
Guo-Dong Zheng, Chun-Xue Zhou, Si-Tong Lin, Jie Chen, Xia-Yun Jiang, Shu-Ming Zou
Insulin-like growth factor binding-protein 5 (igfbp5), the most conserved member of the IGFBP family in vertebrates, plays a critical role in controlling cell survival, growth, differentiation, and apoptosis. Here, we characterized the expression patterns of igfbp5a and igfbp5b in grass carp (Ctenopharyngodon idella), which are retained in many fish species, likely from the teleost-specific whole-genome duplication. Both igfbp5a and igfbp5b encode 268- and 263-aa peptides, respectively, which share a sequence identity of 71%...
November 29, 2016: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/27906093/microrna-140-5p-inhibits-colorectal-cancer-invasion-and-metastasis-by-targeting-adamts5-and-igfbp5
#2
Lihui Yu, Ying Lu, Xiaocui Han, Wenyue Zhao, Jiazhi Li, Jun Mao, Bo Wang, Jie Shen, Shujun Fan, Lu Wang, Mei Wang, Lianhong Li, Jianwu Tang, Bo Song
BACKGROUND: Colorectal cancer (CRC) is one of the most common malignancies in the world. microRNA-140-5p (miR-140) has been shown to be involved in cartilage development and osteoarthritis (OA) pathogenesis. Some contradictions still exist concerning the role of miR-140 in tumor progression and metastasis, and the underlying mechanism is uncertain. METHODS: Immunohistochemistry was performed to determine the expressions of ADAMTS5 and IGFBP5 in CRC tissues. Human CRC cell lines HCT116 and RKO were transfected with miR-140 mimic, inhibitor, or small interfering RNA (siRNA) against ADAMTS5 or IGFBP5, respectively, using oligofectamine or lipofectamine 2000...
December 1, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27893412/molecular-mechanism-and-therapeutic-implications-of-selinexor-kpt-330-in-liposarcoma
#3
Manoj Garg, Deepika Kanojia, Anand Mayakonda, Jonathan W Said, Ngan B Doan, Wenwen Chien, Trivadi S Ganesan, Linda Shyue Huey Chuang, Nachiyappan Venkatachalam, Erkan Baloglu, Sharon Shacham, Michael Kauffman, H Phillip Koeffler
Exportin-1 mediates nuclear export of multiple tumor suppressor and growth regulatory proteins. Aberrant expression of exportin-1 is noted in human malignancies, resulting in cytoplasmic mislocalization of its target proteins. We investigated the efficacy of selinexor against liposarcoma cells both in vitro and in vivo. Exportin-1 was highly expressed in liposarcoma samples and cell lines as determined by immunohistochemistry, western blot, and immunofluorescence assay. Knockdown of endogenous exportin-1 inhibited proliferation of liposarcoma cells...
November 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27835577/a-functional-variant-rs4442975-modulating-foxa1-binding-affinity-does-not-influence-the-risk-or-progression-of-breast-cancer-in-chinese-han-population
#4
Yi Zhang, Yan Li, Shaojie Jiang, Wei Chen, Jiao Lou, Juntao Ke, Jiaoyuan Li, Ying Zhu, Yajie Gong, Yang Yang, Jianbo Tian, Xiating Peng, Danyi Zou, Jing Gong, Jiang Chang, Xiaoping Miao, Rong Zhong
The DNA-binding protein FOXA1 has been shown to regulate nearly all estrogen receptor-chromatin interactions, thereby influencing target gene expression levels in breast cancer (BC) cells. Recently, the rs4442975 T-allele, which disrupts the recruitment of FOXA1 and interacts with the IGFBP5 promoter, was associated to BC susceptibility in a European population. We conducted a hospital-based case-control study that included 1227 cases and 1285 controls to explore the potential association between rs4442975 and BC risk in Chinese Han population, and the effect of this SNP on BC progression was also observed in cases...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27800570/mir-143-regulates-proliferation-and-differentiation-of-bovine-skeletal-muscle-satellite-cells-by-targeting-igfbp5
#5
Wei Ran Zhang, Hui Na Zhang, Yi Min Wang, Yang Dai, Xin Feng Liu, Xin Li, Xiang Bin Ding, Hong Guo
Development of skeletal muscle is a complicated biological process regulated by various regulation factors and signal pathways. MicroRNAs (miRNAs) are novel gene regulators that control muscle cell development. microRNA-143 (miR-143) is highly expressed in skeletal muscle, and we found that miR-143 level is significantly increased during bovine skeletal muscle satellite cells (MSCs) differentiation process through microarray analysis and qRT-PCR detection. However, the function of miR-143 in bovine muscle development remained unclear...
October 31, 2016: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/27706699/increased-mir-155-5p-expression-in-dermal-mesenchymal-stem-cells-of-psoriatic-patients-comparing-the-microrna-expression-profile-by-microarray
#6
R X Hou, R F Liu, X C Zhao, Y R Jia, P An, Z P Hao, J Q Li, X H Li, G H Yin, K M Zhang
Mesenchymal stem cells (MSCs) have pleiotropic immuno-modulatory effects and pro-angiogenic ability, leading to the presumption that MSCs may be involved in the pathogenesis of many inflammatory or autoimmune disorders, including psoriasis. In a previous study, we reported the specific gene expression profile of dermal MSCs from psoriasis. Inflammation- and angiogenesis-related genes, such as lipopolysaccharide-induced tumor necrosis factor-alpha transcription factor (LITAF), dual-specificity protein phosphatase 1 (DUSP1), vascular endothelial growth factor α (VEGFα), and insulin-like growth factor-binding protein-5 (IGFBP5), are abnormally expressed in psoriatic dermal MSCs...
September 2, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27664381/moderate-high-or-low-maternal-protein-diets-change-gene-expression-but-not-the-phenotype-of-skeletal-muscle-from-porcine-fetuses
#7
C Kalbe, D Lösel, J Block, L Lefaucheur, K-P Brüssow, O Bellmann, R Pfuhl, B Puppe, W Otten, C C Metges, C Rehfeldt
The aim of our study was to characterize the immediate phenotypic and adaptive regulatory responses of fetuses to different in utero conditions reflecting inadequate maternal protein supply during gestation. The gilts fed high- (250% above control) or low- (50% under control) protein diets isoenergetically adjusted at the expense of carbohydrates from the day of insemination until the fetuses were collected at day 64 or 94 of gestation. We analyzed body composition, histomorphology, biochemistry, and messenger RNA (mRNA) expression of fetal skeletal muscle...
January 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27639961/marsupial-tammar-wallaby-delivers-milk-bioactives-to-altricial-pouch-young-to-support-lung-development
#8
Vengamanaidu Modepalli, Lyn A Hinds, Julie A Sharp, Christophe Lefevre, Kevin R Nicholas
Our research is exploiting the marsupial as a model to understand the signals required for lung development. Marsupials have a unique reproductive strategy, the mother gives birth to altricial neonate with an immature lung and the changes in milk composition during lactation in marsupials appears to provide bioactives that can regulate diverse aspects of lung development, including branching morphogenesis, cell proliferation and cell differentiation. These effects are seen with milk collected between 25 and 100days postpartum...
September 14, 2016: Mechanisms of Development
https://www.readbyqxmd.com/read/27619487/transcriptional-regulation-of-genes-involved-in-retinoic-acid-metabolism-in-senegalese-sole-larvae
#9
Anaïs Boglino, Marian Ponce, Xavier Cousin, Enric Gisbert, Manuel Manchado
The aim of this study was the characterization of transcriptional regulatory pathways mediated by retinoic acid (RA) in Senegalese sole larvae. For this purpose, pre-metamorphic larvae were treated with a low concentration of DEAB, an inhibitor of RALDH enzyme, until the end of metamorphosis. No differences in growth, eye migration or survival were observed. Nevertheless, gene expression analysis revealed a total of 20 transcripts differentially expressed during larval development and only six related with DEAB treatments directly involved in RA metabolism and actions (rdh10a, aldh1a2, crbp1, igf2r, rarg and cyp26a1) to adapt to a low-RA environment...
September 10, 2016: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/27612043/correlation-between-the-dna-methylation-and-gene-expression-of-igfbp5-in-breast%C3%A2-cancer
#10
Sevgi Karabulut, Zehra Kaya, Gökce Gullu, Irem Peker, Tolga Özmen, Bahadır M Gulluoglu, Handan Kaya, Can Erzik, Ayse Ozer, Mustafa Akkiprik
BACKGROUND: The insulin-like growth factor binding protein5 (IGFBP5) is often dysregulated in human cancers and considered neither a tumor suppressor nor an oncogene. OBJECTIVE: We aim to examine the reason of the changeable gene regulation of IGFBP5 in the case of methylation in breast cancer. METHODS: We used methyl-specific polymerase (MSP) chain reaction to detect CpG methylation of IGFBP5 promoter and exon-I in breast cancer and adjacent tissues...
August 11, 2016: Breast Disease
https://www.readbyqxmd.com/read/27610142/characterization-of-cellular-and-molecular-heterogeneity-of-bone-marrow-stromal-cells
#11
Mona Elsafadi, Muthurangan Manikandan, Muhammad Atteya, Jamil Amjad Hashmi, Zafar Iqbal, Abdullah Aldahmash, Musaad Alfayez, Moustapha Kassem, Amer Mahmood
Human bone marrow-derived stromal stem cells (hBMSC) exhibit multiple functions, including differentiation into skeletal cells (progenitor function), hematopoiesis support, and immune regulation (nonprogenitor function). We have previously demonstrated the presence of morphological and functional heterogeneity of hBMSC cultures. In the present study, we characterized in detail two hTERT-BMSC clonal cell populations termed here CL1 and CL2 that represent an opposing phenotype with respect to morphology, markers expression: alkaline phosphatase (ALP) and CD146, and ex vivo differentiation potential...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27547236/2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine-phip-induces-gene-expression-changes-in-jak-stat-and-mapk-pathways-related-to-inflammation-diabetes-and-cancer
#12
Lora J Rogers, Alexei G Basnakian, Mohammed S Orloff, Baitang Ning, Aiwei Yao-Borengasser, Vinay Raj, Susan Kadlubar
BACKGROUND: 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a heterocyclic aromatic amine (HCA) formed in meat that is cooked at high temperatures and then ingested, can potentially be retained in human adipose tissues. METHODS: To determine if PhIP is bioactive in the adipocyte, we exposed a human adipocyte cell line,HepG2 and Caco-2 cells to low dose PhIP. Uptake and retention of PhIP was determined and cytotoxicity was assessed by the TUNEL assay. Relative expression of PhIP-activating genes (CYP1A1, CYP1A2, SULT1A1 and UGT1A1) was determined by RT-PCR and global expression changes were also examined...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27484838/igfbp5-enhances-osteogenic-differentiation-potential-of-periodontal-ligament-stem-cells-and-wharton-s-jelly-umbilical-cord-stem-cells-via-the-jnk-and-mek-erk-signalling-pathways
#13
Yuejun Wang, Zhi Jia, Shu Diao, Xiao Lin, Xiaomeng Lian, Liping Wang, Rui Dong, Dayong Liu, Zhipeng Fan
OBJECTIVES: Mesenchymal stem cell (MSC)-mediated tissue regeneration represents a promising strategy for repair of tissue defects, but its molecular mechanisms remain unclear, restricting the use of MSCs. Our previous study indicated that insulin-like growth factor-binding protein 5 (IGFBP5) exerted a valuable effect on osteogenic differentiation of MSCs, but its molecular mechanisms underlying directed differentiation remained unclear. In this study, we have investigated the molecular role of IGFBP5 in regulating this osteogenic differentiation potential...
October 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27416040/molecular-signaling-and-dysfunction-of-the-human-reactive-enteric-glial-cell-phenotype-implications-for-gi-infection-ibd-poi-neurological-motility-and-gi-disorders
#14
Andromeda Liñán-Rico, Fabio Turco, Fernando Ochoa-Cortes, Alan Harzman, Bradley J Needleman, Razvan Arsenescu, Mahmoud Abdel-Rasoul, Paolo Fadda, Iveta Grants, Emmett Whitaker, Rosario Cuomo, Fievos L Christofi
BACKGROUND: Clinical observations or animal studies implicate enteric glial cells in motility disorders, irritable bowel syndrome, inflammatory bowel disease, gastrointestinal (GI) infections, postoperative ileus, and slow transit constipation. Mechanisms underlying glial responses to inflammation in human GI tract are not understood. Our goal was to identify the "reactive human enteric glial cell (rhEGC) phenotype" induced by inflammation, and probe its functional relevance. METHODS: Human enteric glial cells in culture from 15 GI-surgical specimens were used to study gene expression, Ca, and purinergic signaling by Ca/fluo-4 imaging and mechanosensitivity...
August 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27402876/an-intergenic-risk-locus-containing-an-enhancer-deletion-in-2q35-modulates-breast-cancer-risk-by-deregulating-igfbp5-expression
#15
Asaf Wyszynski, Chi-Chen Hong, Kristin Lam, Kyriaki Michailidou, Christian Lytle, Song Yao, Yali Zhang, Manjeet K Bolla, Qin Wang, Joe Dennis, John L Hopper, Melissa C Southey, Marjanka K Schmidt, Annegien Broeks, Kenneth Muir, Artitaya Lophatananon, Peter A Fasching, Matthias W Beckmann, Julian Peto, Isabel Dos-Santos-Silva, Elinor J Sawyer, Ian Tomlinson, Barbara Burwinkel, Frederik Marme, Pascal Guénel, Thérèse Truong, Stig E Bojesen, Børge G Nordestgaard, Anna González-Neira, Javier Benitez, Susan L Neuhausen, Hermann Brenner, Aida Karina Dieffenbach, Alfons Meindl, Rita K Schmutzler, Hiltrud Brauch, Heli Nevanlinna, Sofia Khan, Keitaro Matsuo, Hidemi Ito, Thilo Dörk, Natalia V Bogdanova, Annika Lindblom, Sara Margolin, Arto Mannermaa, Veli-Matti Kosma, Anna H Wu, David Van Den Berg, Diether Lambrechts, Hans Wildiers, Jenny Chang-Claude, Anja Rudolph, Paolo Radice, Paolo Peterlongo, Fergus J Couch, Janet E Olson, Graham G Giles, Roger L Milne, Christopher A Haiman, Brian E Henderson, Martine Dumont, Soo Hwang Teo, Tien Y Wong, Vessela Kristensen, Wei Zheng, Jirong Long, Robert Winqvist, Katri Pylkäs, Irene L Andrulis, Julia A Knight, Peter Devilee, Caroline Seynaeve, Montserrat García-Closas, Jonine Figueroa, Daniel Klevebring, Kamila Czene, Maartje J Hooning, Ans M W van den Ouweland, Hatef Darabi, Xiao-Ou Shu, Yu-Tang Gao, Angela Cox, William Blot, Lisa B Signorello, Mitul Shah, Daehee Kang, Ji-Yeob Choi, Mikael Hartman, Hui Miao, Ute Hamann, Anna Jakubowska, Jan Lubinski, Suleeporn Sangrajrang, James McKay, Amanda E Toland, Drakoulis Yannoukakos, Chen-Yang Shen, Pei-Ei Wu, Anthony Swerdlow, Nick Orr, Jacques Simard, Paul D P Pharoah, Alison M Dunning, Georgia Chenevix-Trench, Per Hall, Elisa Bandera, Chris Amos, Christine Ambrosone, Douglas F Easton, Michael D Cole
Breast cancer is the most diagnosed malignancy and the second leading cause of cancer mortality in females. Previous association studies have identified variants on 2q35 associated with the risk of breast cancer. To identify functional susceptibility loci for breast cancer, we interrogated the 2q35 gene desert for chromatin architecture and functional variation correlated with gene expression. We report a novel intergenic breast cancer risk locus containing an enhancer copy number variation (enCNV; deletion) located approximately 400Kb upstream to IGFBP5, which overlaps an intergenic ERα-bound enhancer that loops to the IGFBP5 promoter...
July 11, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27325575/gestation-related-gene-expression-and-protein-localization-in-endometrial-tissue-of-suffolk-and-cheviot-ewes-at-gestation-day-19-after-transfer-of-suffolk-or-cheviot-embryos
#16
M Sequeira, S J Pain, V de Brun, A Meikle, P R Kenyon, H T Blair
The objective of this study was to investigate the gene expression of progesterone and estrogen receptor α (PR, ERα), insulin-like growth factor (IGF) 1, IGF-2, their receptor (IGFR1), IGF-binding proteins (BP) 1 to 6, insulin receptor, adiponectin receptors (AdipoR1/2), cyclooxygenase 2 (PTGS2), mucin 1 and to localize PR, ERα, IGF-1, IGFR1, PTGS2, and proliferating cellular nuclear antigen (PCNA) in the endometrium of pregnant (Day 19) Suffolk and Cheviot ewes carrying Suffolk and Cheviot embryos transferred within and reciprocally between breeds...
October 1, 2016: Theriogenology
https://www.readbyqxmd.com/read/27289152/cell-survival-signaling-in-the-bovine-mammary-gland-during-the-transition-from-lactation-to-involution
#17
K Singh, I Vetharaniam, J M Dobson, M Prewitz, K Oden, R Murney, K M Swanson, R McDonald, H V Henderson, K Stelwagen
In dairy cows, mammary gland involution, and thus a decline in milk production, occurs following peak lactation. To examine the cell signaling pathways regulating involution of the mammary gland, signal transducer and activator of transcription factors (STAT5 and 3), suppressors of cytokine signaling (SOCS1-3 and CIS), insulin-like growth factors (IGF1 and 2), and protein kinase B (Akt) were examined. Mammary involution was induced by termination of milking, and alveolar tissue was collected from 52 nonpregnant, primiparous, mid-lactation Holstein-Friesian cows killed at 0, 6, 12, 18, 24, 36, 72, and 192h postmilking...
September 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27142684/insulin-like-growth-factor-1-in-diabetic-neuropathy-and-amyotrophic-lateral-sclerosis
#18
Stefanie Rauskolb, Benjamin Dombert, Michael Sendtner
Insulin-like growth factor 1 (IGF-1) is a pluripotent growth factor with multiple functions in the peripheral and central nervous system. It supports neuronal survival and axon growth, and also acts on myelinating Schwann cells and oligodendroglia. The biological functions of IGF-1 are modulated by IGF-binding proteins (IGFBPs). Expression of IGF-1 and its corresponding IGF-1 receptor (IGF-1R) are dysregulated in patients with diabetes and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS)...
April 30, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27072650/analysis-of-17%C3%AE-estradiol-e2-role-in-the-regulation-of-corpus-luteum-function-in-pregnant-rats-involvement-of-igfbp5-in-the-e2-mediated-actions
#19
Sudeshna Tripathy, Killivalavan Asaithambi, P Jayaram, R Medhamurthy
BACKGROUND: In several species, considerably higher levels of estradiol-17 (E2) are synthesized in the CL. E2 has been suggested to participate in the regulation of luteal steroidogenesis and luteal cell morphology. In pregnant rats, several experiments have been carried out to examine the effects of inhibition of luteal E2 synthesis on CL structure and function. METHODS: During days 12-15 of pregnancy in rats, luteal E2 was inhibited by way of daily oral administration of anastrozole (AI), a selective non-steroidal aromatase inhibitor, and experiments were also performed with E2 replacement i...
2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27069638/downregulation-of-the-ca-2-activated-k-channel-kc-a3-1-by-histone-deacetylase-inhibition-in-human-breast-cancer-cells
#20
Susumu Ohya, Saki Kanatsuka, Noriyuki Hatano, Hiroaki Kito, Azusa Matsui, Mayu Fujimoto, Sayo Matsuba, Satomi Niwa, Peng Zhan, Takayoshi Suzuki, Katsuhiko Muraki
The intermediate-conductance Ca(2+)-activated K(+) channel KC a3.1 is involved in the promotion of tumor growth and metastasis, and is a potential therapeutic target and biomarker for cancer. Histone deacetylase inhibitors (HDACis) have considerable potential for cancer therapy, however, the effects of HDACis on ion channel expression have not yet been investigated in detail. The results of this study showed a significant decrease in KC a3.1 transcription by HDAC inhibition in the human breast cancer cell line YMB-1, which functionally expresses KCa3...
April 2016: Pharmacology Research & Perspectives
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