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Sexuality and cardiovascular disease

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https://www.readbyqxmd.com/read/28207331/a-systematic-review-of-cardiovascular-disease-in-sexual-minorities
#1
Billy A Caceres, Abraham Brody, Rachel E Luscombe, Jillian E Primiano, Peter Marusca, Edward M Sitts, Deborah Chyun
BACKGROUND: Mental health and HIV disparities are well documented among sexual minorities, but there is a dearth of research on other chronic conditions. Cardiovascular disease remains the leading cause of death worldwide. Although sexual minorities have high rates of several modifiable risk factors for cardiovascular disease (including stress, tobacco use, and alcohol consumption), there is a paucity of research in this area. OBJECTIVES: In this systematic review, we synthesized and critiqued the existing evidence on cardiovascular disease among sexual minority adults...
February 16, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28190476/neuroprotective-properties-of-icariin-in-mptp-induced-mouse-model-of-parkinson-s-disease-involvement-of-pi3k-akt-and-mek-erk-signaling-pathways
#2
Wen-Fang Chen, Lin Wu, Zhong-Rui Du, Lei Chen, Ai-Li Xu, Xiao-Han Chen, Ji-Jun Teng, Man-Sau Wong
BACKGROUND: Epimedium sagittatum is a traditional Chinese herb normally which is used to treat the osteoporosis, cardiovascular dysfunction, and to improve neurological and sexual function in China, Korea and Japan. Icariin is the major active ingredient in Epimedium sagittatum. In the present research, we examined the neuroprotective effects of icariin on dopaminergic neurons and the possible mechanisms in a mouse model of Parkinson's disease (PD). METHODS: Ovariectomized PD mice were treated with vehicle or icariin (3 days before MPTP injections) with or without the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 or mitogen-activated protein kinase kinase (MEK) inhibitor PD98059...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28184201/long-term-high-fat-diet-treatment-an-appropriate-approach-to-study-the-sex-specificity-of-the-autonomic-and-cardiovascular-responses-to-obesity-in-mice
#3
Thiago Bruder-Nascimento, Obioma J Ekeledo, Ruchi Anderson, Huy B Le, Eric J Belin de Chantemèle
Obesity-related cardiovascular disease (CVD) involves increased sympathetic activity in men and male animals. Although women exhibit increased visceral fat, metabolic disorders, inflammation and CVD with obesity, whether body weight gain affects autonomic control of cardiovascular function in females remain unknown. Due to the lack of adequate model to mimic the human pathology, this study aimed to develop a murine model, which would allow studying the sex-specificity of the response of the autonomic nervous system to obesity and identifying the origin of potential sex-differences...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28150293/erectile-dysfunction-as-a-predictor-of-2-year-prognosis-in-acute-myocardial-infarction
#4
Svetlana Apostolovic, Dragana Stanojevic, Ruzica Jankovic-Tomasevic, Sonja Salinger-Martinovic, Tomislav Kostic, Zoran Perisic
BACKGROUND: Erectile dysfunction (ED) is a predictor or marker of coronary artery disease in patients at high risk of cardiovascular diseases. The aim of this study was to investigate the prevalence of ED in patients with acute myocardial infarction (AMI) and after 2 years of follow-up, and to determine the association between ED and the concentrations of the markers of inflammation, endothelial dysfunction and oxidative stress which were measured on the third day after hospital admission...
February 2, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28132040/erectile-dysfunction-as-a-predictor-of-cardiovascular-disease
#5
Sh Janjgava, T Doliashvili
Endothelial dysfunction precedes the clinical stage of atherosclerotic disease and is recognized as an additional risk factor when detecting symptomatic patients. Endothelial function is largely mediated by nitric oxide, and this vasodilatory mechanism is also responsible for the venous and arterial dilatation required to obtain and maintain an erection. The physiological effects and clinical aspects of sexual function have been extensively studied and reported in patients who have angina or who have experienced a myocardial infarction and in those who have undergone coronary artery bypass graft surgery or heart transplant...
December 2016: Georgian Medical News
https://www.readbyqxmd.com/read/28119050/targeted-basic-research-to-highlight-the-role-of-estrogen-and-estrogen-receptors-in-the-cardiovascular-system
#6
REVIEW
Elke Dworatzek, Shokoufeh Mahmoodzadeh
Epidemiological, clinical and animal studies revealed that sex differences exist in the manifestation and outcome of cardiovascular disease (CVD). The underlying molecular mechanisms implicated in these sex differences are not fully understood. The reasons for sex differences in CVD are definitely multifactorial, but major evidence points to the contribution of sex steroid hormone, 17β-estradiol (E2), and its receptors, estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). In this review, we summarize past and present studies that implicate E2 and ER as important determinants of sexual dimorphism in the physiology and pathophysiology of the heart...
January 21, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28052647/the-modulative-effects-of-microcurrent-electrical-nerve-stimulation-on-diabetic-mice
#7
Wen-Ching Huang, Wen-Chieh Chang, Yi-Ju Hsu, Chun-Feng Huang, Chi-Chang Huang, Cheng-Yan Kao, Che-Li Lin
Diabetes (one of non-communicable diseases) is serious due to its complications, such like, cardiovascular ailments, neuropathy, nephropathy, retinopathy, wound gangrene and sexual impotence. Diabetes and associated chronic conditions are rapidly emerging as major health problems. In clinical, there were different drugs for diabetes treatment on different mechanisms. However, there were limited studies on the efficacy of electric stimulations on diabetes therapeutic application. In current study, we try to evaluate the effect of microcurrent electrical nerve stimulator (MENS) on diabetes modulation as an alternative medicine...
28, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28028676/impact-of-autonomic-dysfunctions-on-the-quality-of-life-in-parkinson-s-disease-patients
#8
Svetlana Tomic, Ines Rajkovaca, Vlasta Pekic, Tamer Salha, Sanja Misevic
Autonomic dysfunctions are part of a spectrum of non-motor symptoms in Parkinson's disease (PD) patients. The aim of the study was to assess the prevalence of autonomic dysfunctions and their influence on the quality of life (QoL) in PD patients, adjusted for age, sex, disease duration and motor symptoms. Patients were evaluated for motor function (Unified Parkinson's Disease Rating Scale, UPDRS part III), disease stage (Hoehn and Yahr scale, H&Y scale), autonomic dysfunction (Scales for Outcomes in Parkinson's disease, Autonomic, SCOPA-AUT) and QoL (Parkinson's Disease Questionnaire-39, PDQ-39)...
December 27, 2016: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28012156/sexual-dimorphism-in-obesity-related-genes-in-the-epicardial-fat-during-aging
#9
Caitlin Kocher, Matthew Christiansen, Sarah Martin, Christopher Adams, Paulette Wehner, Todd Gress, Nalini Santanam
Aging increases the risk of cardiovascular disease and metabolic syndrome. Alterations in epicardial fat play an important pathophysiological role in coronary artery disease and hypertension. We investigated the impact of normal aging on obesity-related genes in epicardial fat. Sex-specific changes in obesity-related genes with aging in epicardial fat (EF) were determined in young (6 months) and old (30/36 months) female and male, Fischer 344 × Brown Norway hybrid (FBN) rats, using a rat obesity RT(2) PCR Array...
December 24, 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27989023/sexual-functioning-mirrors-overall-men-s-health-status-even-irrespective-of-cardiovascular-risk-factors
#10
P Capogrosso, E Ventimiglia, L Boeri, U Capitanio, G Gandaglia, F Dehò, F Pederzoli, W Cazzaniga, R Scano, F Montorsi, A Salonia
Erectile dysfunction has been described as a sentinel marker of co-existing and undetected cardiovascular disease. Beside cardiovascular diseases, a correlation between erectile dysfunction and other major comorbidities has been also reported. The study was aimed to analyze the association between sexual functioning and overall men's health in sexually active, Caucasian-European men with new-onset sexual dysfunction. Data from the last 881 consecutive patients seeking first medical help for sexual dysfunction were cross-sectionally analyzed...
January 2017: Andrology
https://www.readbyqxmd.com/read/27988927/cardiac-remodelling-in-a-baboon-model-of-intrauterine-growth-restriction-mimics-accelerated-ageing
#11
Anderson H Kuo, Cun Li, Jinqi Li, Hillary F Huber, Peter W Nathanielsz, Geoffrey D Clarke
KEY POINTS: Rodent models of intrauterine growth restriction (IUGR) successfully identify mechanisms that can lead to short-term and long-term detrimental cardiomyopathies but differences between rodent and human cardiac physiology and placental-fetal development indicate a need for models in precocial species for translation to human development. We developed a baboon model for IUGR studies using a moderate 30% global calorie restriction of pregnant mothers and used cardiac magnetic resonance imaging to evaluate offspring heart function in early adulthood...
November 6, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27988217/attitudes-and-performance-of-cardiologists-toward-sexual-issues-in-cardiovascular-patients
#12
Razieh Salehian, Fatemeh Khodaeifar, Morteza Naserbakht, Azadeh Meybodi
INTRODUCTION: The aim of the present study was to evaluate the attitudes and performance of cardiologists regarding sexual issues in patients with cardiovascular diseases. METHODS: A nationwide survey was conducted in a sample of cardiologists, representative of Iranian cardiologists, in 2015. MAIN OUTCOME MEASURES: Appropriate questionnaires were developed and used to ask participants about their attitudes, performance, and barriers regarding discussing sexual issues with patients with cardiovascular disease...
March 2017: Sexual Medicine
https://www.readbyqxmd.com/read/27929275/erectile-dysfunction
#13
Karl T Rew, Joel J Heidelbaugh
Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It is common, affecting at least 12 million U.S. men. The five-question International Index of Erectile Function allows rapid clinical assessment of ED. The condition can be caused by vascular, neurologic, psychological, and hormonal factors. Common conditions related to ED include diabetes mellitus, hypertension, hyperlipidemia, obesity, testosterone deficiency, and prostate cancer treatment...
November 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27916526/the-mitochondrial-lon-protease-is-required-for-age-specific-and-sex-specific-adaptation-to-oxidative-stress
#14
Laura C D Pomatto, Caroline Carney, Brenda Shen, Sarah Wong, Kelly Halaszynski, Matthew P Salomon, Kelvin J A Davies, John Tower
Multiple human diseases involving chronic oxidative stress show a significant sex bias, including neurodegenerative diseases, cancer, immune dysfunction, diabetes, and cardiovascular disease. However, a possible molecular mechanism for the sex bias in physiological adaptation to oxidative stress remains unclear. Here, we report that Drosophila melanogaster females but not males adapt to hydrogen peroxide stress, whereas males but not females adapt to paraquat (superoxide) stress. Stress adaptation in each sex requires the conserved mitochondrial Lon protease and is associated with sex-specific expression of Lon protein isoforms and proteolytic activity...
January 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/27916220/preventive-and-primary-care-for-lesbian-gay-and-bisexual-patients
#15
REVIEW
Sarah R Floyd, Deidre M Pierce, Stephen A Geraci
Among the minorities underserved by today׳s healthcare system, the lesbian, gay and bisexual (LGB) population may be the least studied, and the least understood by healthcare providers. High-quality evidence is often lacking regarding optimal preventive care measures, both in medical areas that (to date) fail to identify differences in need between LGB and heterosexual patients, and in those more prevalent in or more specific (or both) to sexual minorities. Issues of substance abuse, sexual health and sexually transmitted diseases, obesity and other eating disorders, cardiovascular prevention, cancer prevention and screening, depression and other psychological disorders, social isolation and personal and intimate partner violence are all as or more important to address in LGB patients as they are in the general American population...
December 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27914613/association-between-cardiometabolic-index-and-erectile-dysfunction-a-new-index-for-predicting-cardiovascular-disease
#16
Murat Dursun, Huseyin Besiroglu, Alper Otunctemur, Emin Ozbek
Over the past decade, it has been suggested that erectile dysfunction (ED) is an early indicator of cardiovascular disease. In a recent study, a new index, termed as cardiometabolic index (CMI), was defined and measured as the product of triglyceride (TG)/high-density lipoprotein-cholesterol (HDL-C) ratio and waist-to-height ratio, which are good predictors of coronary artery disease and main components of metabolic syndrome (MetS). All components of the CMI are also included in MetS criteria. Thus, we decided to evaluate the correlation between CMI, including the criteria of MetS, and ED...
December 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27914560/diagnosis-and-treatment-of-testosterone-deficiency-recommendations-from-the-fourth-international-consultation-for-sexual-medicine-icsm%C3%A2-2015
#17
Mohit Khera, Ganesh Adaikan, Jacques Buvat, Serge Carrier, Amr El-Meliegy, Kostas Hatzimouratidis, Andrew McCullough, Abraham Morgentaler, Luiz Otavio Torres, Andrea Salonia
INTRODUCTION: Testosterone deficiency (TD), also known as hypogonadism, is a condition affecting a substantial proportion of men as they age. The diagnosis and management of TD can be challenging and clinicians should be aware of the current literature on this condition. AIM: To review the available literature concerning the diagnosis and management of TD and to provide clinically relevant recommendations from the Fourth International Consultation for Sexual Medicine (ICSM) meeting...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27872030/male-sexual-function-and-smoking
#18
REVIEW
Mark G Biebel, Arthur L Burnett, Hossein Sadeghi-Nejad
INTRODUCTION: Erectile dysfunction (ED) is a common disorder that has many potential etiologies, including hormonal imbalances, psychogenic factors, neurologic disorders, vascular insufficiency, and other risk factors. Cigarette smoking has been well established as a risk factor for cardiovascular disease and stroke, but the relation between smoking and ED is less frequently considered. AIM: To review the current literature that analyzes the association between cigarette smoking and ED...
October 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27843074/testosterone-threshold-for-increased-cardiovascular-risk-in-middle-aged-and-elderly-men-a-locally-weighted-regression-analysis
#19
Pin-Wen Liao, Chia-Chang Wu, Kuan-Chou Chen, Fu-Shan Jaw, Hong-Jeng Yu, Shih-Ping Liu, Chen-Hsun Ho
INTRODUCTION: Although testosterone deficiency has a well-known association with increased risk of cardiovascular disease (CVD), the threshold remains to be determined. AIM: To investigate whether there is a discriminatory testosterone level below which the CVD risk increases. METHODS: The study included 876 men 45 to 74 years old who underwent a general health checkup. The Framingham Risk Score was used to estimate the 10-year CVD risk; a high-sensitivity C-reactive protein (hsCRP) level of at least 1 mg/L was considered an indicator of increased CVD risk...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27832579/screening-and-management-of-risk-factors-for-cardiovascular-disease-in-hiv-positive-patients-attending-an-australian-urban-sexual-health-clinic
#20
Sheena Kakar, Douglas Drak, Tahiya Amin, Jason Cheung, Catherine O'Connor, David Gracey
Background: Few data exist regarding cardiovascular risk among HIV-infected patients attending sexual health clinics (SHC) in Australia. Methods: The medical records of 188 patients attending an inner-city SHC between August 2013 and July 2014 were retrospectively reviewed for cardiovascular risk factors and associated screening and management practices. Results: Cardiovascular risk factors were common among attendees of the SHC, including smoking (38%), hypertension (14%) and dyslipidaemia (11%). Of the 188 patients, 23% reported using potentially cardiotoxic recreational drugs, 25% of dyslipidaemic patients were not on therapy and 10% of patients were hypertensive; none were prescribed treatment...
November 11, 2016: Sexual Health
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