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Sexuality and cardiovascular disease

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https://www.readbyqxmd.com/read/29349250/best-worst-scaling-survey-of-preferences-regarding-the-adverse-effects-of-tobacco-use-in-china
#1
Takeshi Mori, Takahiro Tsuge
We use best-worst scaling to assess two types of concern levels of the adverse consequences of smoking in China. While the smoking cessation policy has worked well in Taiwan, more than 1 million people in mainland China are estimated to die every year from tobacco use. This study compares the preferences of Chinese individuals in the two jurisdictions (mainland versus Taiwan) and explores the possibility of information-based interventions. The relative importance of 13 adverse effects was assessed by conducting a web-based survey on a sample of 480 Chinese participants...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29330031/mental-health-disorders-mediate-association-of-sexual-minority-identity-with-cardiovascular-disease
#2
Lezhou Wu, Randy L Sell, Alexis M Roth, Seth L Welles
BACKGROUND: Little is known about cardiovascular health disparities for lesbian, gay, or bisexual (LGB) persons and whether these disparities are mediated by mental health disorders due to sexual minority stress. We hypothesize LGB identity is associated with an increased risk of cardiovascular disease (CVD) and that major depressive disorder (MDD) and generalized anxiety disorders (GAD) may mediate this association. METHODS: The National Epidemiologic Survey on Alcohol and Related Conditions is a longitudinal, nationally-representative study of non-institutionalized U...
January 9, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29303070/is-there-a-role-for-lifestyle-interventions-in-obsessive-compulsive-and-related-disorders
#3
Leonardo F Fontenelle, Julliana N Quintas, Murat Yücel
Many of the currently available treatments for obsessive-compulsive and related disorders (OCRDs) such as pharmacotherapy augmentation strategies, partial hospitalization programs, deep brain stimulation, and neurosurgery are efficacious for individuals suffering from more severe forms of these conditions. Unfortunately, the application of these treatments in milder forms of illness and subclinical samples, which affect a substantial portion of the population, is not justifiable by their costs (e.g. cognitive-behavioral therapy) and/or potential for side effects (serotonin-reuptake inhibitors associated sexual side effects)...
January 4, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29294902/implications-of-severe-polyvictimization-for-cardiovascular-disease-risk-among-female-survivors-of-violence
#4
Lynette M Renner, Rachael A Spencer, Jamie Morrissette, Angela Lewis-Dmello, Hannah Michel, Deena Anders, Cari Jo Clark
In this study, we examined the impact of severe polyvictimization on 30-year cardiovascular disease (CVD) risk among female survivors of intimate partner violence (IPV). Data were collected from 34 participants in the "Leave it on the Mat" pilot study. The study was conducted in an urban city in a Midwestern state from August 2012 to April 2014. Severe polyvictimization was considered present if participants reported a history of three or more forms of victimization (childhood exposure to domestic violence, being psychologically or physically abused in childhood, and lifetime sexual assault) in addition to IPV...
August 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29283284/endothelial-dysfunction-occurs-independently-of-adipose-tissue-inflammation-and-insulin-resistance-in-ovariectomized-yucatan-miniature-swine
#5
Thomas J Jurrissen, T Dylan Olver, Nathan C Winn, Zachary I Grunewald, Gabriela S Lin, Jessica A Hiemstra, Jenna C Edwards, Michelle L Gastecki, Rebecca J Welly, Craig A Emter, Victoria J Vieira-Potter, Jaume Padilla
In rodents, experimentally-induced ovarian hormone deficiency increases adiposity and adipose tissue (AT) inflammation, which is thought to contribute to insulin resistance and increased cardiovascular disease risk. However, whether this occurs in a translationally-relevant large animal model remains unknown. Herein, we tested the hypothesis that ovariectomy would promote visceral and perivascular AT (PVAT) inflammation, as well as subsequent insulin resistance and peripheral vascular dysfunction in female swine...
December 28, 2017: Adipocyte
https://www.readbyqxmd.com/read/29277644/sex-differences-in-murine-myocardium-are-not-exclusively-regulated-by-gonadal-hormones
#6
Franz Theuring, Boris Neumann, Christian Scheler, Peter R Jungblut, Karima Schwab
We investigated sex differences in cardiac protein patterns of intact and castrated mice using proteomics and 1D and 2D immunoblotting. To exclude differences concerning developmental aspects gonadectomy was conducted in mature mice at the age of three months. The main sex-related regulation in the protein pattern of the myocardium occurred for proteins involved in metabolic processes whereas only few proteins involved in other pathways underwent a regulation. Many regulated proteins (2/3) displayed a characteristic V form, which means that these proteins are up- or down-regulated in sexually mature compared to young mice and are back-regulated after castration, emphasizing a direct regulation by gonadal hormones...
December 19, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29275880/long-term-effects-of-statins-blood-pressure-lowering-and-both-on-erectile-function-in-persons-at-intermediate-risk-for-cardiovascular-disease-a-substudy-of-the-heart-outcomes-prevention-evaluation-3-hope-3-randomized-controlled-trial
#7
Philip Joseph, Eva Lonn, Jackie Bosch, Patricio Lopez, Jun Zhu, Matyas Keltai, Anthony Dans, Christopher Reid, Kamlesh Khunti, William Toff, Leopoldo Piegas, Jae-Hyung Kim, Balakumar Swaminathan, Michael Bohm, Salim Yusuf
BACKGROUND: It is unclear whether modifying cholesterol, blood pressure, or both affect erectile dysfunction. Also, there are concerns that erectile dysfunction is worsened by common medications used to treat these risk factors. In this study, we evaluated the effect of: (1) cholesterol-lowering with a statin; (2) pharmacologic blood pressure reduction; and (3) their combination, on erectile function. METHODS: A priori, this was a secondary analysis of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) randomized controlled trial...
January 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29275061/deterioration-of-chronotropic-responses-and-heart-rate-recovery-indices-in-men-with-erectile-dysfunction
#8
Faruk Kucukdurmaz, Gurkan Acar, Sefa Resim
INTRODUCTION: Erectile dysfunction (ED) and cardiovascular (CV) diseases share common risk factors and ED has been accepted as an early manifestation of CV disease. Exercise stress testing (EST) is used to evaluate CV functions in men with ED. Low exercise workload, a slower heart rate recovery (HRR) after exercise, and inability to increase heart rate during EST (chronotropic incompetence) are independent negative predictors of adverse CV outcomes. AIM: To assess the association among EST parameters, ED, and testosterone levels...
December 20, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/29234483/the-influence-of-emerging-markets-on-the-pharmaceutical-industry
#9
REVIEW
Maya Tannoury, Zouhair Attieh
Emerging markets represent an exceptional opportunity for the pharmaceutical industry. Although a precise definition is not yet available, economists define emerging markets as developing prosperous countries in which investment is expected to result in higher income despite high risks. Qualifying a market as emerging is not merely based on the economic status of the country, but also on several criteria that render the definition applicable to each country. Jim O'Neil, retired chairman of asset management at Goldman Sachs, identified leading economies of emerging markets: Brazil, Russia, India, and China (BRIC) and later Brazil, Russia, India, China, and South Africa (BRICS) and then Mexico, Indonesia, South Korea, and Turkey (MIST), which followed years later as the second tier of nations...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29224108/negative-impact-of-testosterone-deficiency-and-5%C3%AE-reductase-inhibitors-therapy-on-metabolic-and-sexual-function-in-men
#10
Abdulmaged M Traish
Androgens are steroid hormones with pleotropic and diverse biochemical and physiological functions, and androgen deficiency exerts a negative impact on human health. Testosterone (T) either directly or via its transformation into the more potent metabolite 5α-dihydrotestosterone (5α-DHT) or via aromatization into estradiol (E2) modulates important biochemical signaling pathways of human physiology and plays a critical role in the growth and/or maintenance of functions in a host of tissues and organs. T and 5α-DHT play an important role in regulating physiology of the muscle, adipose tissue, liver, bone, and central nervous system, as well as reproductive and sexual functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224092/sex-differences-in-leptin-control-of-cardiovascular-function-in-health-and-metabolic-diseases
#11
Eric J Belin de Chantemèle
Leptin, the adipocyte-derived hormone identified in 1994 for its major role in the control of satiety and body weight regulation, is an adipokine secreted in a sex-specific manner. Although it has clearly been established that females secrete three to four times more leptin than males and that this sexual dimorphism in leptin secretion is exacerbated with overweight and obesity, the origin and the physiological consequences of this sexual dimorphism remain ill-defined. The adipose tissue is the major site of leptin secretion; however, leptin receptors are ubiquitously expressed, conferring to leptin, and indirectly to the adipose tissue, a potential role in the control of numerous physiological functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29184787/correlation-of-self-reported-urologic-symptoms-with-systemic-health-conditions-in-minority-men
#12
Sarah Coleman Vij, Andrew Turk, Tianming Gao, Daniel A Shoskes
Background: To investigate the correlation between presence and severity of urologic symptoms and self-reported systemic health conditions in minority men. Methods: Questionnaires were distributed at a Men's Minority Health Fair. Urologic symptoms were assessed with the International Prostate Symptom Score (IPSS), Sexual Health Inventory for Men (SHIM) and NIH Chronic Prostatitis Symptom Score (CPSI). Each was graded as absent/mild [0], moderate [1] or severe [2] by standard criteria for each and totaled for a urologic score (US)...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29180796/sexual-dysfunction-as-a-determinant-of-cardiovascular-outcome-in-patients-undergoing-chronic-hemodialysis
#13
Vedran Premužić, Bojan Jelaković
Sexual dysfunction (SD) is common in men and women with chronic kidney disease (CKD) and is considered as an early marker for cardiovascular (CV) disease. We hypothesized that patients with SD have higher risk for vascular damage of the large arteries, accelerated vascular aging, and consequently higher CV mortality than other end-stage renal disease (ESRD) patients. In this study, the International Index of Erectile Function (IIEF) questionnaire and the Female Sexual Function Index (FSFI) questionnaire were applied in men and women, respectively...
November 27, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29180795/hypertension-and-obesity-comorbidities-increases-coronary-risk-affects-domains-of-sexual-function-and-sexual-quality-of-life
#14
H Alidu, W K B A Owiredu, N Amidu, C K Gyasi-Sarpong, P P M Dapare, A T Bawah, C Obirikorang, A T Luuse
About 25% of the world's adult population suffers from arterial hypertension with about 1.5 billion estimated to develop hypertension by 2025. Hypertensive patients have been reported to have a higher risk of developing diabetes and sexual dysfunction. Hypertension have been linked with lubricative and orgasmic difficulties in females, as wel as ED and vascular disease in men. Obesity has also been linked to ED in diabetic males as well as several aspects of female sexuality. Hypertension and obesity are closely related, each occurring in greater frequency with the other, it is only logical to think that comorbidities of obesity and hypertension could increase the risk of cardiovascular disease and SD...
November 27, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29180046/proteomics-in-cardiovascular-diseases-unveiling-sex-and-gender-differences-in-the-era-of-precision-medicine
#15
Roberta Baetta, Marta Pontremoli, Alma Martinez Fernandez, Corinne M Spickett, Cristina Banfi
Cardiovascular diseases (CVDs) represent the most important cause of mortality in women and in men. Contrary to the long-standing notion that the effects of the major risk factors on CVD outcomes are the same in both sexes, recent evidence recognizes new, potentially independent, sex/gender-related risk factors for CVDs, and sex/gender-differences in the clinical presentation of CVDs have been demonstrated. Furthermore, some therapeutic options may not be equally effective and safe in men and women. In this context, proteomics offers an extremely useful and versatile analytical platform for biomedical researches that expand from the screening of early diagnostic and prognostic biomarkers to the investigation of the molecular mechanisms underlying CDVs...
November 24, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29171080/testosterone-therapy-for-sexual-dysfunction-in-men-with-type-2-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
M Algeffari, C N Jayasena, P MacKeith, A Thapar, W S Dhillo, N Oliver
AIM: To evaluate the effectiveness of testosterone therapy on a range of sexual function domains in men with Type 2 diabetes. METHOD: Electronic databases were searched for studies investigating the effect of testosterone therapy on sexual function in men with Type 2 diabetes. All randomized controlled trials were considered for inclusion if they compared the efficacy of testosterone therapy with that of placebo and reported sexual function outcomes. Statistical analysis was performed using a random-effects model, and heterogeneity was expressed using the I(2) statistic...
November 24, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29162192/does-striving-to-succeed-come-at-a-physiological-or-psychosocial-cost-for-adults-who-experienced-child-maltreatment
#17
Jenalee R Doom, Vivienne M Hazzard, Katherine W Bauer, Cari Jo Clark, Alison L Miller
While striving to succeed in the face of adversity may provide individuals with outward benefits, it may come at a cost to individuals' physical health. The current study examines whether striving predicts greater physiological or psychosocial costs among those who experienced child maltreatment, a stressor that disrupts the caregiving environment and threatens relationship security. Using data from the National Longitudinal Study of Adolescent to Adult Health, we tested whether greater striving after childhood maltreatment would come at a cost, increasing underlying cardiovascular disease (CVD) risk and depressive symptoms despite showing outward success via income and college degree attainment...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29152440/risperidone-induced-amenorrhea-in-floridly-psychotic-female
#18
Shanila Shagufta, Faiza Farooq, Ali M Khan, Kamil Dar, Abdul Mohit
Despite the high prevalence of hyperprolactinemia in patients receiving antipsychotic medications, its side effects are often neglected. In patients receiving risperidone, the incidence of menstrual abnormalities is relatively small. Our patient was a 44-year-old, Haitian female whose total course of hospitalization was nine months, during most of which she remained floridly psychotic with low cognitive function with waxing and waning symptoms. She developed hyperprolactinemia and amenorrhea on risperidone...
September 13, 2017: Curēus
https://www.readbyqxmd.com/read/29138210/what-happens-after-menopause-wham-protocol-for-a-prospective-multicentre-age-matched-cohort-trial-of-risk-reducing-bilateral-salpingo-oophorectomy-in-high-risk-premenopausal-women
#19
Martha Hickey, Alison Trainer, Sabine Braat, Mary-Ann Davey, Efrosinia Krejany, John Wark
INTRODUCTION: Women at high inherited risk of ovarian cancer are advised to undergo risk-reducing bilateral salpingo-oophorectomy (RRBSO) at age 40-45 years or when their families are complete. Most women are premenopausal at this age, so RRBSO will induce surgical menopause. Despite the clear benefits of RRBSO for cancer risk reduction, much less is known about the impact on non-cancer outcomes that contribute to health and well-being and inform surveillance and management strategies...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29111858/women-s-health-endocrine-update
#20
Ekta Kapoor, Stephanie Faubion, Stephanie Hines, Cynthia A Stuenkel
The clinical update serves as a brief review of recently published, high-impact, and potentially practice changing journal articles summarized for our readers. Topics include menopause, sexual dysfunction, breast health, contraception, osteoporosis, and cardiovascular disease. In this clinical update, we selected four recent high-impact publications related to endocrine issues in women. We have chosen to highlight research on subclinical hypothyroidism during pregnancy and adverse pregnancy outcomes, including cognitive outcomes in offspring; the progression of metabolic syndrome severity during the menopausal transition; and the association of diabetes and metformin use with cancer risk and mortality...
November 7, 2017: Journal of Women's Health
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