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Sex and cardiovascular disease

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https://www.readbyqxmd.com/read/29049200/subclinical-atherosclerosis-and-history-of-cardiovascular-events-in-italian-patients-with-rheumatoid-arthritis-results-from-a-cross-sectional-multicenter-girrcs-gruppo-italiano-di-ricerca-in-reumatologia-clinica-e-sperimentale-study
#1
Piero Ruscitti, Domenico Paolo Emanuele Margiotta, Federica Macaluso, Daniela Iacono, Francesca D'Onofrio, Giacomo Emmi, Fabiola Atzeni, Marcella Prete, Federico Perosa, Piercarlo Sarzi-Puttini, Lorenzo Emmi, Francesco Paolo Cantatore, Giovanni Triolo, Antonella Afeltra, Roberto Giacomelli, Gabriele Valentini
Several studies have pointed out a significant association between rheumatoid arthritis (RA) and accelerated atherosclerosis. At the best of our knowledge, no such study has been carried out in a large Italian series and, in this study, we aimed to investigate the prevalence of both subclinical atherosclerosis and history of cardiovascular events (CVEs), in patients consecutively admitted from January 1, 2015 to December 31, 2015 to Rheumatology Units throughout the whole Italy.Centers members of GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) were invited to enrol patients consecutively admitted from January 1, 2015 to December 31, 2015 and satisfying American College of Rheumatology/ European League Against Rheumatism criteria for RA and to investigate each of them for: traditional cardiovascular risk factors: sex, age, smoking habit, total cholesterol, triglycerides, glycaemia, high blood pressure, metabolic syndrome (MS), type 2 diabetes (T2D); RA features: disease duration as assessed from the first symptom, disease activity as evaluated by DAS28, radiographic damage as assessed by hands and feet x-ray, and previous joint surgery; prevalence of both subclinical atherosclerosis and history of CVEs...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29046988/should-pre-hypertension-be-treated
#2
REVIEW
Hiroshi Kanegae, Takamitsu Oikawa, Kazuomi Kario
Hypertension is an important preventable risk factor for disease and death worldwide. In light of the world's population growth and aging, hypertension is a global public health issue. Many studies have shown associations between pre-hypertension and a higher risk of the future development of hypertension and cardiovascular disease in general populations. However, pre-hypertension per se is not a disease with an immediate high risk, and the clinical value of the identification of pre-hypertension is the potential detection of the early stage of the risk of hypertension and/or cardiovascular disease over an individual's lifespan...
October 18, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/29045309/cardiovascular-mortality-among-76%C3%A2-864-survivors-of-childhood-cancers-in-the-united-states-a-report-from-the-surveillance-epidemiology-and-end-results-program
#3
Saurav Uppal, Sadeer G Al-Kindi, Guilherme H Oliveira
BACKGROUND: Childhood cancer survivors have increased risk for cardiovascular disease. We sought to describe the trends of cardiovascular mortality (CVM) among survivors of childhood cancers in the United States. METHODS: We used the Surveillance, Epidemiology, and End-Results 18 database to identify all children who were diagnosed with childhood cancers between 1973 and 2013. We describe the incidence of CVM in four eras (era 1: 1973-1982, era 2: 1983-1992, era 3: 1993-2002, and era 4: 2003-2013)...
October 16, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29044854/targeted-proteomic-analysis-of-habitual-coffee-consumption
#4
Marilyn C Cornelis, Stefan Gustafsson, Johan Ärnlöv, Sölve Elmståhl, Stefan Söderberg, Johan Sundström, Karl Michaëlsson, Lars Lind, Erik Ingelsson
BACKGROUND: Coffee drinking has been implicated in mortality and a variety of diseases but potential mechanisms underlying these associations are unclear. Large-scale systems epidemiological approaches may offer novel insights to mechanisms underlying associations of coffee with health. OBJECTIVE: We performed an analysis of known and novel protein markers linked to cardiovascular disease and their association with habitual coffee intake in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS, n=816) and followed-up top proteins in the Uppsala Longitudinal Study of Adult Men (ULSAM, n=635) and EpiHealth (n=2418)...
October 16, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29044636/an-inverse-association-between-serum-resistin-levels-and-n-3-polyunsaturated-fatty-acids-intake-was-strongest-in-the-snp-420-g-g-genotype-in-the-japanese-cohort-the-toon-genome-study
#5
Yukinobu Noumi, Ryoichi Kawamura, Yasuharu Tabara, Koutatsu Maruyama, Yasunori Takata, Wataru Nishida, Ai Okamoto, Tatsuya Nishimiya, Hiroshi Onuma, Isao Saito, Takeshi Tanigawa, Haruhiko Osawa
OBJECTIVE: Resistin is secreted from monocytes/macrophages and is associated with insulin resistance, inflammation, and cardiovascular diseases. In the Japanese cohort, serum resistin is tightly associated with a single nucleotide polymorphism (SNP) at -420 (rs1862513) in the promoter region of the human resistin gene. However, interactions between SNP-420 and environmental factors remain to be elucidated. The aim of this study was to investigate the association between serum resistin levels and nutrient intake, and the effect of SNP-420 on this association...
October 17, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29044586/males-with-prolactinoma-are-at-increased-risk-of-incident-cardiovascular-disease
#6
Konstantinos A Toulis, Tim Robbins, Narendra Reddy, Balachandran Kumarendran, Krishna Gokhale, Haren Wijesinghe, Kar Keung Cheng, Niki Karavitaki, John Wass, Krishnarajah Nirantharakumar
OBJECTIVE: To investigate whether the risk of incident cardiovascular disease (CVD) is increased in patients with prolactinoma. DESIGN: Population-based, retrospective, open-cohort study using The Health Improvement Network (THIN) database. PATIENTS: 2,233 patients with prolactinoma and 10,355 matched controls (1:5 ratio) from UK General Practices contributing to THIN were included. Sex, age, body mass index, and smoking status were used as matching parametres...
October 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29041963/is-gout-a-risk-equivalent-to-diabetes-for-stroke-and-myocardial-infarction-a-retrospective-claims-database-study
#7
Jasvinder A Singh, Rekha Ramachandaran, Shaohua Yu, Shuo Yang, Fenglong Xie, Huifeng Yun, Jie Zhang, Jeffrey R Curtis
BACKGROUND: Gout is a risk factor for cardiovascular disease, but associations with specific cardiovascular outcomes, myocardial infarction (MI), and stroke are unclear. Our objective in the present study was to assess whether gout is as strong a risk factor as diabetes mellitus (DM) for incident MI and incident stroke. METHODS: In this retrospective study, we used U.S. claims data from 2007 to 2010 that included a mix of private and public health plans. Four mutually exclusive cohorts were identified: (1) DM only, (2) gout only, (3) gout and DM, and (4) neither gout nor DM...
October 17, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29041879/-adherence-to-therapy-in-the-outpatient-setting-the-ability-to-identify-and-assess-the-effectiveness-of-therapy
#8
T F Ageev, D M Smirnova, D A Deev, V T Fofanova
AIM: To assess adherence of patients to antihypertensive therapy, to determine the role of various factors affecting adherence to treatment by outpatients, and to assess clinical efficacy of a calcium antagonist felodipine. MATERIAL AND METHODS: We examined 5 474 women and men aged >18 years who at visit to a local internist had office systolic arterial pressure (AP) 140-179 and diastolic AP up to 100 mm Hg both on and without hypotensive therapy. Examination included registration of risk factors and concomitant therapy...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29040269/elevated-blood-pressure-and-risk-of-mitral-regurgitation-a-longitudinal-cohort-study-of-5-5-million-united-kingdom-adults
#9
Kazem Rahimi, Hamid Mohseni, Catherine M Otto, Nathalie Conrad, Jenny Tran, Milad Nazarzadeh, Mark Woodward, Terence Dwyer, Stephen MacMahon
BACKGROUND: Mitral regurgitation in people without prior cardiac disease is considered a degenerative disease with no established risk factors for its prevention. We aimed to test the hypothesis that elevated systolic blood pressure (SBP) across its usual spectrum is associated with higher risk of mitral regurgitation. METHODS AND FINDINGS: We used linked electronic health records from the United Kingdom Clinical Practice Research Datalink (CPRD) from 1 January 1990 to 31 December 2015...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29040268/benefit-and-harm-of-intensive-blood-pressure-treatment-derivation-and-validation-of-risk-models-using-data-from-the-sprint-and-accord-trials
#10
Sanjay Basu, Jeremy B Sussman, Joseph Rigdon, Lauren Steimle, Brian T Denton, Rodney A Hayward
BACKGROUND: Intensive blood pressure (BP) treatment can avert cardiovascular disease (CVD) events but can cause some serious adverse events. We sought to develop and validate risk models for predicting absolute risk difference (increased risk or decreased risk) for CVD events and serious adverse events from intensive BP therapy. A secondary aim was to test if the statistical method of elastic net regularization would improve the estimation of risk models for predicting absolute risk difference, as compared to a traditional backwards variable selection approach...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29039145/adiponectin-circulating-levels-and-10-year-2002-2012-cardiovascular-disease-incidence-the-attica-study
#11
Ioannis Kyrou, Olga Tsantarlioti, Demosthenes B Panagiotakos, Constantine Tsigos, Ekavi Georgousopoulou, Christina Chrysohoou, Ioannis Skoumas, Dimitrios Tousoulis, Christodoulos Stefanadis, Christos Pitsavos
PURPOSE: Adiponectin is an adipokine with anti-inflammatory and cardiovascular-protective properties. Existing epidemiological evidence is conflicting on the exact relationship between adiponectin and long-term cardiovascular disease (CVD) risk. Our aim was to prospectively assess whether circulating adiponectin is associated with long-term incident CVD. METHODS: A population-based, prospective study in adults (>18 years) without previous CVD history (ATTICA study)...
October 16, 2017: Endocrine
https://www.readbyqxmd.com/read/29039131/phenotype-disease-severity-and-pain-are-major-determinants-of-quality-of-life-in-fabry-disease-results-from-a-large-multicenter-cohort-study
#12
Maarten Arends, Simon Körver, Derralynn A Hughes, Atul Mehta, Carla E M Hollak, Marieke Biegstraaten
Quality of life (QoL) is decreased in patients with Fabry disease (FD). To improve QoL, it is important to understand the influence of FD related characteristics, symptoms, and complications. In this retrospective cohort study we explored the effect of pain (measured by the Brief Pain Inventory), phenotype, treatment, and FD-related complications on QoL. QoL data of Fabry patients as assessed by the EuroQol five dimension questionnaire (EQ-5D) from two international centers of excellence were collected. The aim of this study was to evaluate the effect of sex, phenotype, age, different states of disease severity, pain, and ERT on EQ-5D utilities...
October 16, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29038853/arterial-ventricular-coupling-in-type-1-diabetes-arterial-stiffness-is-associated-with-impaired-global-longitudinal-strain-in-type-1-diabetes-patients-the-thousand-1-study
#13
Simone Theilade, Peter Rossing, Jan S Jensen, Magnus T Jensen
AIMS: Diabetes is associated with higher arterial stiffness-an early marker of cardiovascular disease. The coupling between arterial stiffness and myocardial function is still unresolved. We investigate associations between arterial stiffness and early myocardial impairment assessed with advanced echocardiography. METHODS: In 305 type 1 diabetes (T1D) patients without known heart disease and with normal left ventricular ejection fraction (LVEF) (biplane LVEF > 45%), we measured arterial stiffness as pulse wave velocity (PWV) and performed conventional and speckle-tracking echocardiography assessing global longitudinal strain (GLS) as a measure of systolic myocardial function...
October 16, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29038593/gender-and-lesion-number-dependent-difference-in-atherogenic-index-of-plasma-in-chinese-people-with-coronary-heart-disease
#14
Wei Ni, Zhenyu Zhou, Tao Liu, Haoyu Wang, Jianping Deng, Xiaoyan Liu, Guoqiang Xing
Few studies has investigated the interrelationship between Atherogenic index of plasma (AIP) and coronary heart disease (CHD) especially in Asians. AIP is the logarithmically transformed ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C), and is thought to be associated with arteriosclerosis, hypertension, diabetes and cardiovascular diseases. Of the 463 patients from Central Hospital of Nanchong in 2011-2014 diagnosed with angiograms, 229 CHD (>50% stenosis in one or more arteries) and the rest 234 were the controls (maximum stenosis < 10% in any artery) according to the world health organization (who) diagnostic criteria...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038386/effect-of-statins-on-patients-and-graft-survival-in-kidney-transplant-recipients-a-survival-meta-analysis
#15
Zohre Rostami, Mahdi Moteshaker Arani, Mahmood Salesi, Mahdi Safiabadi, Behzad Einollahi
INTRODUCTION: Modifying cardiovascular risk factors is very important for the patients after kidney transplantation. Statins are a potentially beneficial intervention for kidney transplant patients, and the effect of statins on cardiovascular outcomes in patients with chronic kidney disease varies according to the stages. This systematic review summarizes the potential beneficial effects of statins on kidney allograft outcome. MATERIALS AND METHODS: A systematic review and meta-analysis was conducted by literature search using the PubMed, Science Direct, Scopus, ISI Web of Knowledge, and Google Scholar...
October 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29038314/physical-activity-reduces-risk-of-premature-mortality-in-patients-with-type-1-diabetes-with-and-without-kidney-disease
#16
Heidi Tikkanen-Dolenc, Johan Wadén, Carol Forsblom, Valma Harjutsalo, Lena M Thorn, Markku Saraheimo, Nina Elonen, Heikki O Tikkanen, Per-Henrik Groop
OBJECTIVE: The aims of the study were to assess how baseline leisure-time physical activity (LTPA) and its exercise components intensity, duration, and frequency are associated with all-cause and cardiovascular mortality in patients with type 1 diabetes 1) overall, 2) stratified by presence or absence of chronic kidney disease (CKD), and 3) stratified by sex. RESEARCH DESIGN AND METHODS: The study design was prospective and observational and included 2,639 patients with type 1 diabetes from the ongoing nationwide multicenter Finnish Diabetic Nephropathy (FinnDiane) Study...
October 16, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29038167/sex-differences-and-similarities-in-atrial-fibrillation-epidemiology-risk-factors-and-mortality-in-community-cohorts-results-from-the-biomarcare-consortium-biomarker-for-cardiovascular-risk-assessment-in-europe
#17
Christina Magnussen, Teemu J Niiranen, Francisco Ojeda, Francesco Gianfagna, Stefan Blankenberg, Inger Njølstad, Erkki Vartiainen, Susana Sans, Gerard Pasterkamp, Maria Hughes, Simona Costanzo, Maria Benedetta Donati, Pekka Jousilahti, Allan Linneberg, Tarja Palosaari, Giovanni de Gaetano, Martin Bobak, Hester M den Ruijter, Ellisiv B Mathiesen, Torben Jørgensen, Stefan Söderberg, Kari Kuulasmaa, Tanja Zeller, Licia Iacoviello, Veikko Salomaa, Renate B Schnabel
Background -Atrial fibrillation (AF) is a common cardiac disease in aging populations with high comorbidity and mortality. Sex differences in AF epidemiology are insufficiently understood. Methods -In N=79 793 individuals without AF diagnosis at baseline (median age, 49.6 years; age range, 24.1-97.6 years; 51.7% women) from 4 community-based European studies (FINRISK, DanMONICA, Molisani Northern Sweden) of the BiomarCaRE consortium (Biomarker for Cardiovascular Risk Assessment in Europe), we examined AF incidence, its association with mortality, common risk factors, biomarkers, and prevalent cardiovascular disease, and their attributable risk by sex...
October 16, 2017: Circulation
https://www.readbyqxmd.com/read/29038147/imputation-of-baseline-ldl-cholesterol-concentration-in-patients-with-familial-hypercholesterolemia-on-statins-or-ezetimibe
#18
Isabelle Ruel, Sumayah Aljenedil, Iman Sadri, Émilie de Varennes, Robert A Hegele, Patrick Couture, Jean Bergeron, Eric Wanneh, Alexis Baass, Robert Dufour, Daniel Gaudet, Diane Brisson, Liam R Brunham, Gordon A Francis, Lubomira Cermakova, James M Brophy, Arnold Ryomoto, G B John Mancini, Jacques Genest
BACKGROUND: Familial hypercholesterolemia (FH) is the most frequent genetic disorder seen clinically and is characterized by increased LDL cholesterol (LDL-C) (>95th percentile), family history of increased LDL-C, premature atherosclerotic cardiovascular disease (ASCVD) in the patient or in first-degree relatives, presence of tendinous xanthomas or premature corneal arcus, or presence of a pathogenic mutation in the LDLR, PCSK9, or APOB genes. A diagnosis of FH has important clinical implications with respect to lifelong risk of ASCVD and requirement for intensive pharmacological therapy...
October 16, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29036517/response-to-letter-from-moise-and-bertoni-regarding-sex-differences-in-the-association-of-diabetes-with-cardiovascular-disease-outcomes-among-african-americans-and-whites-in-the-atherosclerosis-risk-in-communities-aric-study-by-george-et-al-2017
#19
Kristen M George, Elizabeth Selvin, James S Pankow, B Gwen Windham, Aaron R Folsom
No abstract text is available yet for this article.
October 4, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29036484/sex-differences-in-the-association-of-diabetes-with-cardiovascular-disease-outcomes-among-african-americans-and-whites-in-the-atherosclerosis-risk-in-communities-aric-study
#20
Kristen M George, Elizabeth Selvin, James S Pankow, B Gwen Windham, Aaron R Folsom
Sex by diabetes interaction on cardiovascular disease (CVD) has been established in whites; however, it is unknown if this interaction occurs in African Americans. We hypothesized that is a multiplicative sex by diabetes interaction for CVD among blacks in ARIC, 1987-2013. Race-specific Cox models were run in three stages; stage 1 examined baseline diabetes status, stage 2-baseline diabetes status with the competing risk of non-CVD death, and stage 3- time-varying diabetes status with a competing risk of non-CVD death...
October 4, 2017: American Journal of Epidemiology
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