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https://www.readbyqxmd.com/read/29474865/trajectories-of-plasma-igf-1-igfbp-3-and-their-ratio-in-the-mayo-clinic-study-of-aging
#1
Alexandra M V Wennberg, Clinton E Hagen, Ronald C Petersen, Michelle M Mielke
Insulin-like growth factor 1 (IGF-1) has been associated with osteoporosis, cardiovascular disease, cancer, neurodegenerative diseases, and mortality in middle and older aged adults. Cross-sectionally, IGF-1 decreases with age and levels of IGF-1 are markedly different between individuals. However, little is known about intra-individual trajectories of IGF-1. We examined baseline and serial measures of plasma total IGF-1, IGF binding protein (IGFBP)-3, and their ratio, which is a proxy for bioavailable IGF-1, among 1618 adults, aged 50-95, enrolled in the Mayo Clinic Study of Aging...
February 20, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29474844/cardiac-output-in-pre-eclampsia-is-associated-with-the-presence-of-fetal-growth-restriction-not-gestation-at-onset-a-prospective-cohort-study
#2
Jasmine Tay, Lin Foo, Giulia Masini, Phillip R Bennett, Carmel M Mceniery, Ian B Wilkinson, Christoph C Lees
BACKGROUND AND OBJECTIVES: Pre-eclampsia (PE) and fetal growth restriction (FGR) are considered to be placentally-mediated disorders. The clinical manifestations are widely held to relate to gestation age at onset with early- and late-onset PE considered to be phenotypically distinct. Recent studies have reported conflicting findings in relation to cardiovascular function, and in particular cardiac output, in PE and FGR. STUDY DESIGN: We investigated maternal cardiovascular function in relation to clinical subtype in 45 pathological pregnancies (14 'PE only', 16 'FGR only', 15 'PE and FGR') and compared these with 107 healthy person observations...
February 20, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29474816/coffee-for-cardioprotection-and-longevity
#3
REVIEW
James H O'Keefe, James J DiNicolantonio, Carl J Lavie
Coffee, a complex brew containing hundreds of biologically active compounds, exerts potent effects on long-term human health. Recently, a plethora of studies have been published focusing on health outcomes associated with coffee intake. An inverse association between coffee consumption and all-cause mortality has been seen consistently in large prospective studies. Habitual coffee consumption is also associated with lower risks for cardiovascular (CV) death and a variety of adverse CV outcomes, including coronary heart disease (CHD), congestive heart failure (HF), and stroke; coffee's effects on arrhythmias and hypertension are neutral...
February 20, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29473758/arterial-stiffness-in-women-previously-with-preeclampsia-from-a-semi-rural-region-of-south-africa
#4
A Namugowa, J Iputo, J Wandabwa, A Meeme, G A B Buga, S Abura, Y Y Stofile
Women with pre-eclampsia have an increased risk of cardiovascular disease later in life. The aim of the study was to establish the presence and pattern of arterial stiffness in women previously with pre-eclampsia from a semi-rural region of South Africa. This was a prospective longitudinal study which involved 36 previously pre-eclamptic women and 86 non-pregnant controls (NPC) who had a past history of non-complicated pregnancy. Maternal wave reflection (augmentation index) and carotid-femoral pulse wave velocity were assessed noninvasively, using applanation tonometry with the SphygmoCor device...
February 23, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29473516/the-essential-role-of-primary-caregiver-in-early-detection-of-familial-hypercholesterolemia-and-cardiovascular-prevention
#5
Julie St-Pierre, Isabelle Ruel, Jacques Genest
Familial hyterolemipercholesa (FH) is a worldwide common autosomal inherited condition associated with premature cardiovascular diseases, both in men and in women (World frequency has been recently estimated to be as high as 1:250). Identifying FH cases early in life could represent a cornerstone to prevent adult's life fatal events. Pediatricians are well positioned to evaluate the familial cardiovascular risk factors among their young patients, to make a diagnosis and to perform familial screening. The goal of this paper is therefore to emphasize the recognition of this genetic condition at a younger age and to initiate both familial screening and a safe treatment...
February 21, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29473119/impact-of-age-at-diagnosis-and-duration-of-type-2-diabetes-on-mortality-in-australia-1997-2011
#6
Lili Huo, Dianna J Magliano, Fanny Rancière, Jessica L Harding, Natalie Nanayakkara, Jonathan E Shaw, Bendix Carstensen
AIMS/HYPOTHESIS: Current evidence suggests that type 2 diabetes may have a greater impact on those with earlier diagnosis (longer duration of disease), but data are limited. We examined the effect of age at diagnosis of type 2 diabetes on the risk of all-cause and cause-specific mortality over 15 years. METHODS: The data of 743,709 Australians with type 2 diabetes who were registered on the National Diabetes Services Scheme (NDSS) between 1997 and 2011 were examined...
February 22, 2018: Diabetologia
https://www.readbyqxmd.com/read/29472380/spontaneous-coronary-artery-dissection-current-state-of-the-science-a-scientific-statement-from-the-american-heart-association
#7
REVIEW
Sharonne N Hayes, Esther S H Kim, Jacqueline Saw, David Adlam, Cynthia Arslanian-Engoren, Katherine E Economy, Santhi K Ganesh, Rajiv Gulati, Mark E Lindsay, Jennifer H Mieres, Sahar Naderi, Svati Shah, David E Thaler, Marysia S Tweet, Malissa J Wood
Spontaneous coronary artery dissection (SCAD) has emerged as an important cause of acute coronary syndrome, myocardial infarction, and sudden death, particularly among young women and individuals with few conventional atherosclerotic risk factors. Patient-initiated research has spurred increased awareness of SCAD, and improved diagnostic capabilities and findings from large case series have led to changes in approaches to initial and long-term management and increasing evidence that SCAD not only is more common than previously believed but also must be evaluated and treated differently from atherosclerotic myocardial infarction...
February 22, 2018: Circulation
https://www.readbyqxmd.com/read/29472266/long-term-mortality-in-outpatients-with-type-2-diabetes-in-a-reference-hospital-in-cameroon-a-retrospective-cohort-study
#8
Joyce B Foryoung, Chobufo Ditah, Peter Nde Fon, Yannick Mboue-Djieka, Daniel N Nebongo, Noel D Mbango, Vanessa Balla, Simeon-Pierre Choukem
OBJECTIVES: There are limited data on mortality in patients with type 2 diabetes mellitus (T2DM) in Sub-Saharan Africa. We aimed at determining the mortality rate, and the causes and the predictors of death in patients with T2DM followed as outpatients in a reference hospital in Cameroon. DESIGN: Retrospective cohort study. SETTING: A reference hospital in Cameroon. PARTICIPANTS: From December 2015 to March 2016, patients with T2DM aged 18 years and older and who consulted between January 2009 and December 2014, were contacted directly or through their next of kin, and included in this study...
February 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29469650/prenatal-androgen-exposure-causes-hypertension-and-gut-microbiota-dysbiosis
#9
Shermel Sherman, Nadeen Sarsour, Marziyeh Salehi, Allen Schroering, Blair Mell, Bina Joe, Jennifer W Hill
BACKGROUND: Conditions of excess androgen in women, such as polycystic ovary syndrome (PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS may be increased in daughters of affected women is through exposure to elevated androgens in utero. Hyperandrogenemic conditions have serious health consequences, including increased risk for hypertension and cardiovascular disease. Recently, gut dysbiosis has been found to induce hypertension in rats, such that blood pressure can be normalized through fecal microbial transplant...
February 22, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29466210/-elevated-level-of-the-natriuretic-peptide-among-adult-population-in-regions-participating-in-the-esse-rf-study-and-its-association-with-cardiovascular-diseases-and-risk-factors
#10
S A Shalnova, A E Imaeva, A D Deev, V A Metelskaya, G A Muromtseva, A O Konradi, V P Masenko, A Y Efanov, N V Kulakova, O P Rotar, I A Trubacheva, A A Shabunova, E V SHlyakhto, S A Boytsov
AIM: to study associations between elevated blood plasma concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP), risk factors and cardiovascular diseases (CVD) in samples of adult population of Russian Federation (RF) aged 25-64 years. MATERIALS AND METHODS: We analyzed data of examination of representative samples of population of 5 regions of RF obtained within the framework of the multicenter ESSE-RF study (2012-2013). Number of examined subjects was 8 077 (3 176 men)...
December 2017: Kardiologiia
https://www.readbyqxmd.com/read/29463579/characteristics-and-prognosis-in-women-and-men-with-type-1-diabetes-undergoing-coronary-angiography-a-nationwide-registry-report
#11
Viveca Ritsinger, Christel Hero, Ann-Marie Svensson, Nawzad Saleh, Bo Lagerqvist, Katarina Eeg-Olofsson, Anna Norhammar
OBJECTIVE: To describe sex aspects on extent of coronary artery disease (CAD) and prognosis in a contemporary population with type 1 diabetes. RESEARCH DESIGN AND METHODS: All patients undergoing coronary angiography, 2001-2013, included in the Swedish Coronary Angiography and Angioplasty Registry and the Swedish National Diabetes Register as type 1 diabetes were followed for mortality until 31 December 2013. The coronary angiogram was classified into normal and one-, two-, three-, and left main vessel disease...
February 20, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29463390/managing-congenital-heart-disease-in-the-obstetric-patient
#12
REVIEW
Heidi M Connolly
OBJECTIVE: Cardiovascular disease is the major cause of pregnancy-related maternal mortality in the United States, and congenital heart disease (CHD) is the most common form of structural heart disease affecting women of childbearing age. Most females born with CHD will reach childbearing age and consider pregnancy. Adult CHD and maternal-fetal medicine (MFM) specialists managing women with CHD should provide preconception counseling, cardiovascular risk assessment prior to pregnancy that estimates maternal and fetal risk, management during pregnancy, and in the peripartum period and also know the potential complications and special circumstances that may occur in the post-partum period...
February 2018: Seminars in Perinatology
https://www.readbyqxmd.com/read/29462263/regular-yogurt-intake-and-risk-of-cardiovascular-disease-among-hypertensive-adults
#13
Justin R Buendia, Yanping Li, Frank B Hu, Howard J Cabral, M Loring Bradlee, Paula A Quatromoni, Martha R Singer, Gary C Curhan, Lynn L Moore
BACKGROUND: High blood pressure (HBP) is a major cardiovascular disease (CVD) risk factor. Clinical trials including Dietary Approaches to Stop Hypertension (DASH) have demonstrated beneficial effects of dairy consumption on risks of HBP and CVD. Yogurt, a fermented dairy product, may independently be related to CVD risk. OBJECTIVE: To evaluate the association between yogurt consumption and CVD risk among hypertensive individuals in 2 large cohorts and to determine whether the association differs among those whose eating pattern more closely resembles the DASH diet...
February 15, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29462100/exercise-training-in-at-risk-black-and-white-women-a-comparative-cohort-analyses
#14
Megan Bowdon, Pamela Marcovitz, Susanna K Jain, Judith Boura, Kaitlin G Liroff, Barry A Franklin
PURPOSE: Few data are available regarding the impact of exercise interventions in black women at risk for cardiovascular disease (CVD). METHODS: Women ≥18 years without known CVD with ≥1 coronary risk factor were enrolled in a community-based exercise program ≥3 days per/week for ≥30 min/session for 6 months. Exercise training intensity ~50[FIGURE DASH]80% of functional capacity, using heart rate (HR) and/or rating of perceived exertion (RPE) as the primary intensity modulators...
February 16, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29461227/-the-differentiated-approach-to-prevention-of-neural-tube-defects-in-children
#15
N Kotova, V Maichuk, O Fedorenko
Neural tube defects occupy second place in frequency after the defects of the cardiovascular system. The folate metabolism violation and hyperhomocysteinemia in women are proved to be the leading risk factors for the NTD of the fetus. Polymorphism of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) is a genetic determinant of folate metabolism violation. Admission of folic acid in a standard dose of 0.4 mg and / or the use of fortified foods does not allow reaching the protective level of folic acid if there is a mutation of the MTHFR gene or when several risk factors combine, which requires a higher dose of folic acid...
January 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29460812/the-acute-effect-of-black-tea-consumption-on-resistance-artery-endothelial-function-in-healthy-subjects-a-randomized-controlled-trial
#16
Arno Greyling, Thalijn L C Wolters, David M de Bresser, Sean H P P Roerink, Niels P Riksen, Theo P Mulder, Matthew J Rowson, Maria T Hopman, Dick H J Thijssen
BACKGROUND & AIMS: Black tea is a main source of flavonoids in the Western diet and has been associated with reduced risk for cardiovascular disease, possibly through lowering blood pressure. These effects may be mediated through improving endothelial function of resistance arteries. The aim of this study was therefore to examine the acute impact of black tea on forearm resistance artery endothelial function in healthy, normotensive middle-aged subjects. METHODS: Twenty middle-aged men and women (age-range 45-75 years) were recruited into a double-blind, randomized, placebo-controlled crossover intervention study...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29460788/metabolic-syndrome-among-rural-indian-adults
#17
Anamitra Barik, Kausik Das, Abhijit Chowdhury, Rajesh Kumar Rai
BACKGROUND & AIMS: To prevent an increasing level of mortality due to type 2 diabetes mellitus and cardiovascular disease among the rural Indian population, a management strategy of the metabolic syndrome (MetS) should be devised. This study aims to estimate the burden of MetS and its associated risk factors. METHODS: Data from the Birbhum Population Project covering 9886 individuals (4810 male and 5076 female population) aged ≥18 years were used. The burden of metabolic syndrome, as defined by the Third Report of the National Cholesterol Education Program Adult Treatment Panel, was determined...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29460261/baseline-and-changes-in-serum-uric-acid-independently-predict-11-year-incidence-of-metabolic-syndrome-among-community-dwelling-women
#18
R Kawamoto, D Ninomiya, Y Kasai, K Senzaki, T Kusunoki, N Ohtsuka, T Kumagi
INTRODUCTION: Metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. In women, increased serum uric acid (SUA) levels are associated with MetS and its components. However, whether baseline and changes in SUA predict incidence of MetS and its components remains unclear. METHODS: The subjects comprised 407 women aged 71 ± 8 years from a rural village. We have identified participants who underwent a similar examination 11 years ago, and examined the relationship between baseline and changes in SUA, and MetS based on the modified criteria of the National Cholesterol Education Program's Adult Treatment Panel (NCEP-ATP) III report...
February 19, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29459794/impaired-cardiac-function-in-patients-with-multiple-sclerosis-by-comparison-with-normal-subjects
#19
Raluca Ileana Mincu, Stefania Lucia Magda, Sorina Mihaila, Maria Florescu, Diana Janina Mihalcea, Andreea Velcea, Adela Chiru, Cristina Tiu, Bogdan Ovidiu Popescu, Mircea Cinteza, Dragos Vinereanu
Multiple sclerosis (MS), neurologic disease affecting young population, may cause cardiovascular dysfunction, due to autonomous nervous dysfunction, physical invalidity, increased oxidative stress, and systemic inflammatory status. However, cardiovascular function is rarely evaluated in these patients. We assessed left and right ventricular (LV and RV) function by 2D, 3D, tissue Doppler, and speckle tracking echocardiography, and vascular function by remodeling, stiffness, and endothelial dysfunction parameters in patients with MS, compared to control subjects...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29459472/association-of-spontaneous-preterm-delivery-and-future-maternal-cardiovascular-disease
#20
REVIEW
Margo B Minissian, Sarah Kilpatrick, Jo-Ann Eastwood, Wendie A Robbins, Eynav E Accortt, Janet Wei, Chrisandra L Shufelt, Lynn V Doering, C Noel Bairey Merz
Cardiovascular disease (CVD) risk factors are well established. However, little is known about a woman's cardiovascular response to pregnancy, which appears to be an early marker of future maternal CVD risk. Spontaneous preterm delivery (sPTD) has been associated with a ≤3-fold increased risk of maternal CVD death later in life compared with having a term delivery. This review focuses on 3 key areas to critically assess the association of sPTD and future maternal CVD risk: (1) CVD risk factors, (2) inflammatory biomarkers of interest, and (3) specific forms of vascular dysfunction, such as endothelial function and arterial stiffness, and mechanisms by which each may be linked to sPTD...
February 20, 2018: Circulation
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