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Hba1c cardiovascular risk

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https://www.readbyqxmd.com/read/28713663/correlation-between-glycated-hemoglobin-and-triglyceride-level-in-type-2-diabetes-mellitus
#1
Syeda Naqvi, Shabnam Naveed, Zeeshan Ali, Syed Masroor Ahmad, Raad Asadullah Khan, Honey Raj, Shoaib Shariff, Chintan Rupareliya, Fatima Zahra, Saba Khan
CONTEXT: Dyslipidemia is quite prevalent in non-insulin dependent diabetes mellitus. Maintaining tight glycemic along with lipid control plays an essential role in preventing micro- and macro-vascular complications associated with diabetes. PURPOSE: The main purpose of the study was to highlight the relationship between glycosylated hemoglobin (HbA1c) and triglyceride levels. This may in turn help in predicting the triglyceride status of type 2 diabetics and therefore identifying patients at increased risk from cardiovascular events...
June 13, 2017: Curēus
https://www.readbyqxmd.com/read/28711972/the-relationship-of-blood-glucose-with-cardiovascular-disease-is-mediated-over-time-by-traditional-risk-factors-in-type-1-diabetes-the-dcct-edic-study
#2
Ionut Bebu, Barbara H Braffett, Rodica Pop-Busui, Trevor J Orchard, David M Nathan, John M Lachin
AIMS/HYPOTHESIS: Chronic hyperglycaemia, as measured by HbA1c levels, is a major risk factor for atherosclerosis and cardiovascular disease (CVD) in type 1 diabetes. Our aim was to describe the degree to which the effect of HbA1c on the risk of CVD is mediated by its effect on traditional risk factors over time, and how these mediation pathways change over time. METHODS: The DCCT and its observational follow-up study, the Epidemiology of Diabetes Interventions and Complications (EDIC), followed 1441 participants for a mean of 27 years, with periodic measurement of HbA1c and risk factors over time...
July 16, 2017: Diabetologia
https://www.readbyqxmd.com/read/28711469/targeting-weight-loss-interventions-to-reduce-cardiovascular-complications-of-type-2-diabetes-a-machine-learning-based-post-hoc-analysis-of-heterogeneous-treatment-effects-in-the-look-ahead-trial
#3
Aaron Baum, Joseph Scarpa, Emilie Bruzelius, Ronald Tamler, Sanjay Basu, James Faghmous
BACKGROUND: The Action for Health in Diabetes (Look AHEAD) trial investigated whether long-term cardiovascular disease morbidity and mortality could be reduced through a weight loss intervention among people with type 2 diabetes. Despite finding no significant reduction in cardiovascular events on average, it is possible that some subpopulations might have derived benefit. In this post-hoc analysis, we test the hypothesis that the overall neutral average treatment effect in the trial masked important heterogeneous treatment effects (HTEs) from intensive weight loss interventions...
July 12, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28705184/prevalence-of-gestational-diabetes-mellitus-based-on-various-screening-strategies-in-western-kenya-a-prospective-comparison-of-point-of-care-diagnostic-methods
#4
Sonak D Pastakia, Benson Njuguna, Beryl Ajwang' Onyango, Sierra Washington, Astrid Christoffersen-Deb, Wycliffe K Kosgei, Ponnusamy Saravanan
BACKGROUND: Early diagnosis of gestational diabetes mellitus (GDM) is crucial to prevent short term delivery risks and long term effects such as cardiovascular and metabolic diseases in the mother and infant. Diagnosing GDM in Sub-Saharan Africa (SSA) however, remains sub-optimal due to associated logistical and cost barriers for resource-constrained populations. A cost-effective strategy to screen for GDM in such settings are therefore urgently required. We conducted this study to determine the prevalence of gestational diabetes mellitus (GDM) and assess utility of various GDM point of care (POC) screening strategies in a resource-constrained setting...
July 14, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28704534/short-term-variation-in-ntprobnp-after-lifestyle-intervention-in-severe-obesity
#5
Debora Fedele, Virginia Bicchiega, Alessandro Collo, Federica Barutta, Erika Pistone, Gabriella Gruden, Graziella Bruno
AIM: Natriuretic peptides are not only involved in cardiovascular adaption to various conditions, but also in metabolic diseases. We performed this study to assess the effect of a very short time of lifestyle inpatient intervention on NTproBNP values in normotensive subjects with severe obesity and normal cardiac function. METHODS: We recruited 14 consecutive obese normotensive subjects with normal cardiac function who were aged 30 years and more and were referred to inpatient rehabilitation in an academic clinic over a two months period...
2017: PloS One
https://www.readbyqxmd.com/read/28702259/clinical-effects-cardiovascular-and-renal-outcomes-associated-with-rapid-acting-insulin-analogs-among-individuals-with-type-2-diabetes-a-nation-wide-observational-cohort-study
#6
Ann-Marie Svensson, Mervete Miftaraj, Stefan Franzén, Björn Eliasson
BACKGROUND: Rapid-acting insulin analogs (RAIs) have not been examined for long-term safety in randomized clinical trials. We performed a nationwide longitudinal cohort study among individuals with type 2 diabetes (T2DM) to address cardiovascular safety and mortality among users of lispro, aspart and glulisine insulins. METHODS: We used four national registers, following patients previously not treated with RAI but with continuous use of RAIs in 2005-2014 up to 6...
2017: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/28697799/symmetric-and-asymmetric-dimethylarginine-as-risk-markers-of-cardiovascular-disease-all-cause-mortality-and-deterioration-in-kidney-function-in-persons-with-type-2-diabetes-and-microalbuminuria
#7
Emilie H Zobel, Bernt Johan von Scholten, Henrik Reinhard, Frederik Persson, Tom Teerlink, Tine W Hansen, Hans-Henrik Parving, Peter K Jacobsen, Peter Rossing
BACKGROUND: To evaluate symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA) as risk markers of cardiovascular disease, all-cause mortality and deterioration in renal function in a well characterised type 2 diabetic population with microalbuminuria and without symptoms of coronary artery disease. METHODS: 200 participants followed for 6.1 years. SDMA and ADMA were measured at baseline. Endpoints included (1) composite cardiovascular endpoint (n = 40); (2) all-cause mortality (n = 26); and (3) decline in eGFR of >30% (n = 42)...
July 11, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28695552/glycaemic-blood-pressure-and-lipid-goal-attainment-and-chronic-kidney-disease-stage-of-type-2-diabetic-patients-treated-in-primary-care-practices
#8
Antonella Corcillo, Edward Pivin, Fabrice Lalubin, Nelly Pitteloud, Michel Burnier, Anne Zanchi
INTRODUCTION: The prevalence of chronic kidney disease and diabetes is rising in Europe. These patients are at high cardiovascular and renal risk and need a challenging multifactorial therapeutic approach. METHOD: The goal of this cross-sectional study was to examine the treatment and attainments of goals related to cardiovascular risk factors within chronic kidney disease stages in type 2 diabetic patients followed up by primary care physicians in Switzerland. Each participating physician entered into a web database the anonymised data of up to 15 consecutive diabetic patients attending her/his office between December 2013 and June 2014...
July 11, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28691497/increased-mortality-risk-in-diabetic-patients-discharged-from-hospital-with-insulin-therapy-after-an-acute-myocardial-infarction-data-from-the-fast-mi-2005-registry
#9
Vincent Bataille, Jean Ferrières, Nicolas Danchin, Etienne Puymirat, Marianne Zeller, Tabassome Simon, Didier Carrié
BACKGROUND: Merits of insulin use for diabetes treatment in patients with advanced atherosclerosis are debated. This observational study conducted in diabetic patients after an acute myocardial infarction aimed to assess whether insulin prescription at discharge (IPD) was related to all-cause mortality during follow-up. METHODS: Subjects were diabetic patients admitted in intensive- or coronary-care units for acute myocardial infarction (consecutively recruited in 223 centres in France) and discharged alive from the hospital, with or without an IPD...
July 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28683835/reduced-hdl-function-in-children-and-young-adults-with-type-1-diabetes
#10
Martin Heier, Mark S Borja, Cathrine Brunborg, Ingebjørg Seljeflot, Hanna Dis Margeirsdottir, Kristian F Hanssen, Knut Dahl-Jørgensen, Michael N Oda
BACKGROUND: Patients with type 1 diabetes (T1D) are at increased risk of cardiovascular disease (CVD). Measures of high-density lipoprotein (HDL) function provide a better risk estimate for future CVD events than serum levels of HDL cholesterol. The objective of this study was to evaluate HDL function in T1D patients shortly after disease onset compared with healthy control subjects. METHODS: Participants in the atherosclerosis and childhood diabetes study were examined at baseline and after 5 years...
July 6, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28683796/effectiveness-of-dapagliflozin-on-vascular-endothelial-function-and-glycemic-control-in-patients-with-early-stage-type-2-diabetes-mellitus-defence-study
#11
Fumika Shigiyama, Naoki Kumashiro, Masahiko Miyagi, Kayoko Ikehara, Eiichiro Kanda, Hiroshi Uchino, Takahisa Hirose
BACKGROUND: Recent studies reported that sodium glucose cotransporter 2 (SGLT2) inhibitors can potentially reduce the risk of cardiovascular mortality in patients with type 2 diabetes mellitus (T2DM). However, there is little or no information on the therapeutic effects of SGLT2 inhibitors on the progression of atherosclerosis. This dapagliflozin effectiveness on vascular endothelial function and glycemic control (DEFENCE) study was designed to determine the effects of dapagliflozin, a SGLT2 inhibitor, on endothelial function in patients with early-stage T2DM...
July 6, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28683240/prevalence-of-diabetes-in-greater-beirut-area-worsening-over-time
#12
Mona P Nasrallah, Nancy F Nakhoul, Lara Nasreddine, Youssef Mouneimne, Mohamad G Abiad, Hussein Ismaeel, Hani Tamim
OBJECTIVE: The Middle East North Africa region has one of the highest rates of diabetes, both in prevalence and in rate of increase. The aim of this study was to examine the prevalence and associated risk factors of Type 2 diabetes mellitus (T2D) in the adult population of Beirut. METHODS: A random sample of 501 men and women aged 18 to79 years was examined in a cross-sectional manner. The sample was then divided into three groups, based on T2D self-report, HbA1C, and fasting glucose (no diabetes or ND, at risk for diabetes or RD, and probable diabetes or PD)...
July 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28680356/the-effect-of-early-substitution-of-subclinical-hypothyroidism-on-biochemical-blood-parameters-and-the-quality-of-life
#13
Milena S Pandrc, Anđelka Ristić, Vanja Kostovski, Marko Stanković, Vladimir Antić, Jelena Milin-Lazović, Jasmina Ćirić
BACKGROUND: Subclinical hypothyroidism (SCH) is defined as high TSH and normal thyroxine. Data on the effects of early substitution by levothyroxine on psychophysical health in SCH are still not consistent enough to support its introduction. METHODS: Clinical parameters, biochemical data and quality of life (Short Form 36 questionnaire) were measured before the intervention and 3 months after the euthyroid state had been achieved in SCH patients. RESULTS: Significant reduction in body weight (p=0...
April 2017: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28678550/the-safety-of-albiglutide-for-the-treatment-of-type-2-diabetes
#14
Marc S Rendell
Albiglutide is a marketed long acting GLP-1 receptor agonist (GLP-1 RA) administered by weekly injection. It has significantly less gastrointestinal side effects than other GLP-1 RAs in current use but does not improve HbA1c or promote weight loss to the same extent as competitor agents such as liraglutide. Area Covered: The safety of albiglutide is discussed. The review encompassed a search of PubMed and a thorough analysis of the European Union and US Food and Drug Administration approval documents. Expert Opinion: Unlike competitor agents, the gastrointestinal side effects of albiglutide are not much greater than placebo...
July 5, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28676377/is-there-a-connection-between-postprandial-hyperglycemia-and-igt-related-sensory-nerve-dysfunction
#15
N Németh, Z Putz, I Istenes, A E Körei, O E Vági, M Kempler, R Gandhi, G Jermendy, S Tesfaye, Á G Tabák, P Kempler
BACKGROUND AND AIMS: To assess the risk factors for sensory nerve dysfunction in subjects with isolated impaired glucose tolerance (IGT). METHODS AND RESULTS: Seventy-two people with isolated IGT (WHO 1999 criteria) and 39 gender and age-matched healthy volunteers underwent detailed clinical and neurological assessment including quantitative sensory testing using the Neurometer device (current perception threshold measurement on four limbs at three different frequencies)...
May 11, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28674146/self-reported-sleep-duration-and-napping-cardiac-risk-factors-and-markers-of-subclinical-vascular-disease-cross-sectional-study-in-older-men
#16
Shahrzad Zonoozi, Sheena E Ramsay, Olia Papacosta, Lucy Lennon, Elizabeth A Ellins, Julian P J Halcox, Peter H Whincup, S Goya Wannamethee
STUDYOBJECTIVES: Daytime sleep has been associated with increased risk of cardiovascular disease and heart failure (HF), but the mechanisms remain unclear. We have investigated the association between daytime and night-time sleep patterns and cardiovascular risk markers in older adults including cardiac markers and subclinical markers of atherosclerosis (arterial stiffness and carotid intima-media thickness (CIMT)). METHODS: Cross-sectional study of 1722 surviving men aged 71-92 examined in 2010-2012 across 24 British towns from a prospective study initiated in 1978-1980...
July 2, 2017: BMJ Open
https://www.readbyqxmd.com/read/28663384/ct-angiography-images-of-coronary-artery-stenosis-provide-a-better-prediction-of-risk-than-traditional-risk-factors-in-asymptomatic-individuals-with-type-2-diabetes-a-long-term-study-of-clinical-outcomes
#17
Kwan Yong Lee, Byung-Hee Hwang, Tae-Hoon Kim, Chan Jun Kim, Jin-Jin Kim, Eun-Ho Choo, Ik Jun Choi, Young Choi, Ha-Wook Park, Yoon-Seok Koh, Pum-Joon Kim, Jong Min Lee, Mi-Jeong Kim, Doo Soo Jeon, Jae-Hyoung Cho, Jung Im Jung, Ki-Bae Seung, Kiyuk Chang
OBJECTIVE: We investigated the efficacy of coronary computed tomography angiography (CCTA) in predicting the long-term risks in asymptomatic patients with type 2 diabetes and compared it with traditional risk factors. RESEARCH DESIGN AND METHODS: We analyzed 933 patients with asymptomatic type 2 diabetes who underwent CCTA. Stenosis was considered obstructive (≥50%) in each coronary artery segment using CCTA. The extent and severity scores for coronary artery disease (CAD) were evaluated...
June 29, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28662955/determining-the-threshold-for-hba1c-as-a-predictor-for-adverse-outcomes-after-total-joint-arthroplasty-a-multicenter-retrospective-study
#18
Majd Tarabichi, Noam Shohat, Michael M Kheir, Muyibat Adelani, David Brigati, Sean M Kearns, Pankajkumar Patel, John C Clohisy, Carlos A Higuera, Brett R Levine, Ran Schwarzkopf, Javad Parvizi, William A Jiranek
BACKGROUND: Although HbA1c is commonly used for assessing glycemic control before surgery, there is no consensus regarding its role and the appropriate threshold in predicting adverse outcomes. This study was designed to evaluate the potential link between HbA1c and subsequent periprosthetic joint infection (PJI), with the intention of determining the optimal threshold for HbA1c. METHODS: This is a multicenter retrospective study, which identified 1645 diabetic patients who underwent primary total joint arthroplasty (1004 knees and 641 hips) between 2001 and 2015...
May 11, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28662164/associations-of-sitting-accumulation-patterns-with-cardio-metabolic-risk-biomarkers-in-australian-adults
#19
John Bellettiere, Elisabeth A H Winkler, Sebastien F M Chastin, Jacqueline Kerr, Neville Owen, David W Dunstan, Genevieve N Healy
BACKGROUND: High amounts of time spent sitting can increase cardiovascular disease risk and are deleteriously associated cardio-metabolic risk biomarkers. Though evidence suggests that accruing sitting time in prolonged periods may convey additional risk, verification using high-quality measures is needed. We examined this issue in adults from the Australian Diabetes, Obesity and Lifestyle Study, using accurate measures of sitting accumulation. METHODS: In 2011/12, 739 adults aged 36 to 89 years (mean±SD 58±10 years) wore activPAL3™ monitors (which provide accurate objective measures of sitting); 678 provided ≥4 valid days of monitor data and complete cardio-metabolic biomarker and confounder data...
2017: PloS One
https://www.readbyqxmd.com/read/28659867/increased-short-term-beat-to-beat-qt-interval-variability-in-patients-with-impaired-glucose-tolerance
#20
Andrea Orosz, István Baczkó, Szabolcs Nyiraty, Anna E Körei, Zsuzsanna Putz, Róbert Takács, Attila Nemes, Tamás T Várkonyi, László Balogh, György Ábrahám, Péter Kempler, Julius Gy Papp, András Varró, Csaba Lengyel
Prediabetic states and diabetes are important risk factors for cardiovascular morbidity and mortality. Determination of short-term QT interval variability (STVQT) is a non-invasive method for assessment of proarrhythmic risk. The aim of the study was to evaluate the STVQT in patients with impaired glucose tolerance (IGT). 18 IGT patients [age: 63 ± 11 years, body mass index (BMI): 31 ± 6 kg/m(2), fasting glucose: 6.0 ± 0.4 mmol/l, 120 min postload glucose: 9.0 ± 1.0 mmol/l, hemoglobin A1c (HbA1c): 5...
2017: Frontiers in Endocrinology
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