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Fundus autofluorescence

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https://www.readbyqxmd.com/read/28202480/multimodal-imaging-findings-in-hyper-early-stage-mewds
#1
Armelle Cahuzac, Benjamin Wolff, Thibaud Mathis, Marie-Hélène Errera, José-Alain Sahel, Martine Mauget-Faÿsse
OBJECTIVE: To describe a new stage of multiple evanescent white dot syndrome (MEWDS), occurring at a very early phase of the disease. METHODS: Retrospective analysis of clinical, angiographic and tomographic findings in four patients with 'hyper-early' stage MEWDS. RESULTS: In four patients seen within 1 week of the onset of symptoms, fundus analysis revealed macular granity and the classic yellow-white dots, some having no corresponding hyperautofluorescent pattern...
February 15, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28199885/evaluation-of-polyesteramide-pea-and-polyester-plga-microspheres-as-intravitreal-drug-delivery-systems-in-albino-rats
#2
Tobias Peters, Seong-Woo Kim, Vinicius Castro, Krunoslav Stingl, Torsten Strasser, Sylvia Bolz, Ulrich Schraermeyer, George Mihov, MengMeng Zong, Vanessa Andres-Guerrero, Rocio Herrero Vanrell, Aylvin A Dias, Neil R Cameron, Eberhart Zrenner
PURPOSE: To study the suitability of injectable microspheres based on poly(ester amide) (PEA) or poly lactic-co-glycolic acid (PLGA) as potential vehicles for intravitreal drug delivery in rat eyes. Dexamethasone-loaded PEA microspheres (PEA + DEX) were also evaluated. METHODS: Forty male Sprague Dawley rats were divided into four groups that received different intravitreally injected microspheres: PEA group (n = 12); PLGA group (n = 12); PEA + DEX group (n = 8); and control group (no injection, n = 8)...
February 7, 2017: Biomaterials
https://www.readbyqxmd.com/read/28195603/classification-of-exudative-age-related-macular-degeneration-with-pachyvessels-on-en-face-swept-source-optical-coherence-tomography
#3
Danny Siu-Chun Ng, Malini Bakthavatsalam, Frank Hiu-Ping Lai, Carol Yim-Lui Cheung, Gemmy Chu-Ming Cheung, Fang Yao Tang, Chi Wai Tsang, Timothy Yuk-Yau Lai, Tien Yin Wong, Mårten Erik Brelén
Purpose: The purpose of this study was to classify exudative maculopathy by the presence of pachyvessels on en face swept-source optical coherence tomography (SSOCT). Methods: Consecutive patients with signs of exudative maculopathy underwent SSOCT, fluorescein and indocyanine green angiography (ICGA), ultra-widefield fundus color photography, and autofluorescence examinations. Images were analyzed in a masked fashion by two sets of four examiners in different sessions: (1) the presence of pachyvessels in en face OCT and (2) features of exudative maculopathy in conventional imaging modalities...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28187978/optical-coherence-tomography-examination-of-the-retinal-pigment-epithelium-in-best-vitelliform-macular-dystrophy
#4
Cynthia X Qian, Dionisio Charran, Cameron R Strong, Timothy J Steffens, Thiran Jayasundera, John R Heckenlively
PURPOSE: To describe the anatomic changes and natural history of vitelliform lesions in Best vitelliform macular dystrophy (BVMD) using spectral-domain optical coherence tomography (OCT). DESIGN: Prospective comparative case series. PARTICIPANTS: Twenty patients (40 eyes) with molecular confirmation of mutation in the BEST1 gene and 20 age-matched controls were included. METHODS: Color fundus photographs, fundus autofluorescence, and spectral-domain OCT were obtained, and these findings were compared between the 2 groups...
February 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28166161/characterizing-photoreceptor-changes-in-acute-posterior-multifocal-placoid-pigment-epitheliopathy-using-adaptive-optics
#5
Philipp K Roberts, Peter L Nesper, Alex C Onishi, Dimitra Skondra, Lee M Jampol, Amani A Fawzi
PURPOSE: To characterize lesions of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) by multimodal imaging including adaptive optics scanning laser ophthalmoscopy (AOSLO). METHODS: We included patients with APMPPE at different stages of evolution of the placoid lesions. Color fundus photography, spectral domain optical coherence tomography, infrared reflectance, fundus autofluorescence, and AOSLO images were obtained and registered to correlate microstructural changes...
February 3, 2017: Retina
https://www.readbyqxmd.com/read/28161925/the-use-of-microperimetry-to-detect-functional-progression-in-non-neovascular-age-related-macular-degeneration-a-systematic-review
#6
REVIEW
Evan N Wong, Avenell L Chew, William H Morgan, Praveen J Patel, Fred K Chen
We reviewed the current literature on the ability of microperimetry to detect non-neovascular age-related macular degeneration (AMD) disease progression. The index test was retinal sensitivity measurement assessed by microperimetry and comparators were other functional measures (best-corrected and low-luminance visual acuities, and fixation stability) and structural parameters [retinal thickness, choroidal thickness, and area of geographic atrophy (GA) determined by color fundus photographs, short-wave or near-infrared fundus autofluorescence]...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28161916/the-pathway-from-genes-to-gene-therapy-in-glaucoma-a-review-of-possibilities-for-using-genes-as-glaucoma-drugs
#7
REVIEW
Teresa Borrás
We reviewed the current literature on the ability of microperimetry to detect non-neovascular age-related macular degeneration (AMD) disease progression. The index test was retinal sensitivity measurement assessed by microperimetry and comparators were other functional measures (best-corrected and low-luminance visual acuities, and fixation stability) and structural parameters [retinal thickness, choroidal thickness, and area of geographic atrophy (GA) determined by color fundus photographs, short-wave or near-infrared fundus autofluorescence]...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28159970/the-clinical-phenotype-of-cnga3-related-achromatopsia-pretreatment-characterization-in-preparation-of-a-gene-replacement-therapy-trial
#8
Ditta Zobor, Annette Werner, Franco Stanzial, Francesco Benedicenti, Günther Rudolph, Ulrich Kellner, Christian Hamel, Sten Andréasson, Gergely Zobor, Torsten Strasser, Bernd Wissinger, Susanne Kohl, Eberhart Zrenner
Purpose: The purpose of this study was to clinically characterize patients with CNGA3-linked achromatopsia (CNGA3-ACHM) in preparation of a gene therapy trial. Methods: Thirty-six patients (age 7-56 years) with complete (cACHM) or incomplete (iACHM) CNGA3-ACHM were examined, including detailed psychophysical tests, extended electrophysiology, and assessment of morphology by fundus autofluorescence and spectral-domain optical coherence tomography (SD-OCT). Results: Mean best-corrected visual acuity was 0...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28147405/prominent-optic-disc-featured-in-inherited-retinopathy
#9
M G Todorova, R I Bojinova, C Valmaggia, D F Schorderet
Background We investigated the relationship between prominent optic disc (POD) and inherited retinal dystrophy (IRD). Patients and Methods A cross-sectional consecutive study was performed in 10 children and 11 adults of 7 non-related families. We performed clinical phenotyping, including a detailed examination, fundus autofluorescence, and colour fundus and OCT imaging. Genetic testing was subsequently performed for all family members presenting retinal pathology. Results In 4 members of a 3-generation family, hyperfluorescent deposits on the surface of POD were related to a p...
February 1, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28145658/frequency-and-clinical-characteristics-of-hydroxychloroquine-retinopathy-in-korean-patients-with-rheumatologic-diseases
#10
Doo Ri Eo, Min Gyu Lee, Don Il Ham, Se Woong Kang, Jaejoon Lee, Hoon Suk Cha, Eunmi Koh, Sang Jin Kim
This study aimed to evaluate the frequency and clinical characteristics of hydroxychloroquine (HCQ) retinopathy in Korean patients with rheumatologic diseases. We retrospectively reviewed medical records of 310 patients taking HCQ. Ophthalmic examinations included spectral-domain optical coherence tomography (SD-OCT), automated visual field test, and fundus autofluorescence. The severity of retinopathy was categorized as early, moderate, or severe, and the location was categorized as parafoveal, pericentral, or mixed pattern...
March 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28141766/choroidal-nevus-a-review-of-prevalence-features-genetics-risks-and-outcomes
#11
Jason L Chien, Kareem Sioufi, Thamolwan Surakiatchanukul, Jerry A Shields, Carol L Shields
PURPOSE OF REVIEW: To review the prevalence, clinical features, imaging findings, cytogenetics, and risks and outcomes of choroidal nevus. RECENT FINDINGS: Choroidal nevus is a benign melanocytic tumor, often discovered incidentally on ophthalmic examination. This lesion is generally well circumscribed and pigmented. The prevalence of choroidal nevus in postequatorial region in United States adults (≥40 years old) is approximately 5%. Choroidal nevus is associated with higher lifetime unopposed estrogen and greater BMI...
January 30, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28109563/imaging-protocols-in-clinical-studies-in-advanced-age-related-macular-degeneration-recommendations-from-classification-of-atrophy-consensus-meetings
#12
Frank G Holz, SriniVas R Sadda, Giovanni Staurenghi, Moritz Lindner, Alan C Bird, Barbara A Blodi, Ferdinando Bottoni, Usha Chakravarthy, Emily Y Chew, Karl Csaky, Christine A Curcio, Ron Danis, Monika Fleckenstein, K Bailey Freund, Juan Grunwald, Robyn Guymer, Carel B Hoyng, Glenn J Jaffe, Sandra Liakopoulos, Jordi M Monés, Akio Oishi, Daniel Pauleikhoff, Philip J Rosenfeld, David Sarraf, Richard F Spaide, Ramin Tadayoni, Adnan Tufail, Sebastian Wolf, Steffen Schmitz-Valckenberg
PURPOSE: To summarize the results of 2 consensus meetings (Classification of Atrophy Meeting [CAM]) on conventional and advanced imaging modalities used to detect and quantify atrophy due to late-stage non-neovascular and neovascular age-related macular degeneration (AMD) and to provide recommendations on the use of these modalities in natural history studies and interventional clinical trials. DESIGN: Systematic debate on the relevance of distinct imaging modalities held in 2 consensus meetings...
January 18, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28106236/chorioretinal-folds-in-a-patient-with-multiple-myeloma-treated-with-stem-cell-transplant
#13
Jia S Poon, Kaveh Vahdani, Adam P Booth
PURPOSE: To report an unusual case of bilateral choroidal folds related to multiple myeloma. METHODS: In this case report, fundus photography, fundus fluorescein angiography, fundus autofluorescence, and B-ultrasonography were used to assess posterior segment changes. RESULTS: A 55-year-old woman with history of multiple myeloma was found to have abnormal fundi. Clinical examination and investigations confirmed chorioretinal folds, which was considered to be related to myeloma...
January 16, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28101049/tuberculous-subretinal-abscess-in-a-non-hiv-patient-with-miliary-tuberculosis
#14
Eugenia Paez Soria, Paula Magnano, Ariel Schlaen, Paula Luvini, Gisela Arevalo Calderon, Mauricio Martinez Cartier, Pablo Chiaradía, Cristóbal Couto
This case report describes the features of a tuberculous subretinal abscess in a non-HIV patient. It includes the characterization of the lesion with spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence examination. SD-OCT and autofluorescence imaging showed external retinal involvement during development of the tuberculous subretinal abscess. Patients with tuberculous lesions need a multidisciplinary approach, since the disease may involve any part of the body. In this case in particular, incidental findings at computed tomography scan led to the detection of this rare ocular manifestation of tuberculous disease...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28099314/fundus-autofluorescence-lifetimes-and-central-serous-chorioretinopathy
#15
Chantal Dysli, Lieselotte Berger, Sebastian Wolf, Martin S Zinkernagel
PURPOSE: To quantify retinal fluorescence lifetimes in patients with central serous chorioretinopathy (CSC) and to identify disease specific lifetime characteristics over the course of disease. METHODS: Forty-seven participants were included in this study. Patients with central serous chorioretinopathy were imaged with fundus photography, fundus autofluorescence, optical coherence tomography, and fluorescence lifetime imaging ophthalmoscopy (FLIO) and compared with age-matched controls...
January 17, 2017: Retina
https://www.readbyqxmd.com/read/28098738/subretinal-cell-based-therapy-an-analysis-of-surgical-variables-to-increase-cell-survival
#16
David J Wilson, Martha Neuringer, Jonathan Stoddard, Lauren M Renner, Steven Bailey, Andreas Lauer, Trevor J McGill
PURPOSE: To develop a novel surgical approach to provide consistent delivery of cell suspension into the subretinal space without cell leakage into the vitreous. METHODS: Cell viability was assessed following mock injections to determine the optimal size cannula for delivery of the cells. A pars plana without vitrectomy approach was used to create a subretinal bleb with balanced salt solution using a 41-gauge cannula. GFP-labeled retinal pigment epithelium cells were injected through transretinal (n = 8) and transscleral (n = 16) injection approaches...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098736/foveal-exudate-and-choroidal-neovascularization-in-atypical-cases-of-multiple-evanescent-white-dot-syndrome
#17
Kevin C Chen, Marcela Marsiglia, Rosa Dolz-Marco, Sarwar Zahid, Sarah Mrejen, Jose S Pulido, Salomon Y Cohen, Benjamin Freilich, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To describe atypical cases of multiple evanescent white dot syndrome (MEWDS) associated with foveal exudation, increased choroidal thickness, and secondary Type 2 (subretinal) neovascularization. METHODS: Four cases of atypical MEWDS were studied at a retina referral center. Patients underwent evaluation with multimodal retinal imaging, including fluorescein angiography, indocyanine green angiography, spectral-domain and enhanced depth imaging optical coherence tomography (OCT)...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098709/multimodal-imaging-during-the-evolution-of-blood-brain-barrier-disruption-maculopathy
#18
Bikramjit P Pal, Tapani Palosaari, Tero Kivelä
PURPOSE: To highlight the course of blood-brain barrier disruption maculopathy in a patient with successfully managed relapsed central nervous system lymphoma. METHODS: Case report with fundus autofluorescence and optical coherence tomography imaging, and literature review. RESULTS: A 57-year-old patient diagnosed with central nervous system large B-cell lymphoma had a normal ophthalmic evaluation on his first visit. Subsequently, when his malignancy recurred locally, he was started on blood-brain barrier disruption therapy and intraarterial methotrexate...
January 16, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28098621/long-term-follow-up-of-retinal-pigment-epithelium-restoration-after-a-triple-tear
#19
Sarwar Zahid, Rosa Dolz Marco, K Bailey Freund
PURPOSE: To demonstrate longitudinal multimodal imaging findings in a case of neovascular age-related macular degeneration presenting with multiple retinal pigment epithelium (RPE) tears showing progressive RPE restoration. METHODS: Observational clinical case report. RESULTS: A 79-year-old woman diagnosed with neovascular age-related macular degeneration developed 3 consecutive RPE tears in her right eye during the course of treatment with intravitreal anti-vascular endothelial growth factor therapy...
December 19, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28095071/mevalonate-kinase-deficiency-associated-with-ataxia-and-retinitis-pigmentosa-in-two-brothers-with-mvk-gene-mutations
#20
Ulrich Kellner, Heidi Stöhr, Silke Weinitz, Ghazaleh Farmand, Bernhard H F Weber
PURPOSE: To report the clinical and molecular genetic findings in two brothers with retinitis pigmentosa (RP) and mevalonate kinase deficiency (MKD). METHODS: The brothers were examined clinically and with fundus autofluorescence, near-infrared autofluorescence, and spectral domain optical coherence tomography. Targeted resequencing was done with a custom designed gene panel containing 78 genes associated with RP. Mutations were confirmed by direct Sanger sequencing...
January 17, 2017: Ophthalmic Genetics
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