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https://www.readbyqxmd.com/read/28110316/insensitivity-of-pi3k-akt-gsk3-signaling-in-peripheral-blood-mononuclear-cells-of-age-related-macular-degeneration-patients
#1
Liu Xunxian, Yao Zemin
Our recent studies with cultured retinal pigment epithelium cells suggested that overexpression of interleukin 17 receptor C (IL-17RC), a phenomenon observed in peripheral blood and chorioretinal tissues with age-related macular degeneration (AMD), was associated with altered activation of phosphatidylinositide 3-kinase (PI3K), Akt, and glycogen synthase kinase 3 (GSK3). We wondered whether or not altered PI3K, Akt, and GSK3 activities could be detected in peripheral blood mononuclear cells (PBMC) obtained from AMD patients...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28109563/imaging-protocols-in-clinical-studies-in-advanced-age-related-macular-degeneration-recommendations-from-classification-of-atrophy-consensus-meetings
#2
Frank G Holz, SriniVas R Sadda, Giovanni Staurenghi, Moritz Lindner, Alan C Bird, Barbara A Blodi, Ferdinando Bottoni, Usha Chakravarthy, Emily Y Chew, Karl Csaky, Christine A Curcio, Ron Danis, Monika Fleckenstein, K Bailey Freund, Juan Grunwald, Robyn Guymer, Carel B Hoyng, Glenn J Jaffe, Sandra Liakopoulos, Jordi M Monés, Akio Oishi, Daniel Pauleikhoff, Philip J Rosenfeld, David Sarraf, Richard F Spaide, Ramin Tadayoni, Adnan Tufail, Sebastian Wolf, Steffen Schmitz-Valckenberg
PURPOSE: To summarize the results of 2 consensus meetings (Classification of Atrophy Meeting [CAM]) on conventional and advanced imaging modalities used to detect and quantify atrophy due to late-stage non-neovascular and neovascular age-related macular degeneration (AMD) and to provide recommendations on the use of these modalities in natural history studies and interventional clinical trials. DESIGN: Systematic debate on the relevance of distinct imaging modalities held in 2 consensus meetings...
January 18, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28108569/five-year-progression-of-unilateral-age-related-macular-degeneration-to-bilateral-involvement-the-three-continent-amd-consortium-report
#3
Nichole Joachim, Johanna Maria Colijn, Annette Kifley, Kristine E Lee, Gabriëlle H S Buitendijk, Barbara E K Klein, Chelsea E Myers, Stacy M Meuer, Ava G Tan, Elizabeth G Holliday, John Attia, Gerald Liew, Sudha K Iyengar, Paulus T V M de Jong, Albert Hofman, Johannes R Vingerling, Paul Mitchell, Caroline C W Klaver, Ronald Klein, Jie Jin Wang
PURPOSE: To assess the 5-year progression from unilateral to bilateral age-related macular degeneration (AMD) and associated risk factors. DESIGN: Pooled data analyses of three prospective population-based cohorts, the Blue Mountains Eye Study, Beaver Dam Eye Study and Rotterdam Study. METHODS: Retinal photography and interview with comprehensive questionnaires were conducted at each visit of three studies. AMD was assessed following the modified Wisconsin AMD grading protocol...
January 20, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28107458/neuropilin-1-involvement-in-choroidal-and-retinal-neovascularisation
#4
Patricia Fernández-Robredo, Senthil Selvam, Michael B Powner, Dawn A Sim, Marcus Fruttiger
PURPOSE: Inhibiting VEGF is the gold standard treatment for neovascular age-related macular degeneration (AMD). It is also effective in preventing retinal oedema and neovascularisation (NV) in diabetic retinopathy (DR) and retinal vein occlusions (RVO). Neuropilin 1 (Nrp1) is a co-receptor for VEGF and many other growth factors, and therefore a possible alternative drug target in intra ocular neovascular disease. Here we assessed choroidal and retinal NV in an inducible, endothelial specific knock out model for Nrp1...
2017: PloS One
https://www.readbyqxmd.com/read/28106709/systemic-pharmacokinetics-and-pharmacodynamics-of-intravitreal-aflibercept-bevacizumab-and-ranibizumab
#5
Robert L Avery, Alessandro A Castellarin, Nathan C Steinle, Dilsher S Dhoot, Dante J Pieramici, Robert See, Stephen Couvillion, Maʼan A Nasir, Melvin D Rabena, Mauricio Maia, Sherri Van Everen, Kha Le, William D Hanley
PURPOSE: To evaluate the systemic pharmacokinetics (PKs) of aflibercept, bevacizumab, and ranibizumab in patients with neovascular age-related macular degeneration (AMD), diabetic macular edema (DME), or retinal vein occlusion (RVO). METHODS: Prospective, open-label, nonrandomized clinical trial of patients with AMD, DME, or RVO who were antivascular endothelial growth factor (VEGF) naïve or had not received anti-VEGF for ≥4 months. Patients received 3 monthly intravitreal injections of aflibercept 2...
January 18, 2017: Retina
https://www.readbyqxmd.com/read/28105123/effect-of-anti-vegf-drugs-combined-with-photodynamic-therapy-in-the-treatment-of-age-related-macular-degeneration
#6
Yi Dong, Guangming Wan, Panshi Yan, Yue Chen, Wenzhan Wang, Guanghua Peng
We analyzed the effects of anti-vascular endothelial growth factor (VEGF) drugs combined with photodynamic therapy (PDT) in the treatment of age-related macular degeneration (AMD). Ninety-six cases (192 eyes) of AMD were included in this study and randomly divided into the observation group and control group (n=48 cases per group). The control group was administered the treatment of Lucentis intravitreal injection alone and the observation group was administered Lucentis combined with PDT. The therapeutic effects were compared...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28104803/microrna-processing-enzymes-are-essential-for-survival-and-function-of-mature-retinal-pigmented-epithelial-cells-in-mice
#7
Thomas R Sundermeier, Sanae Sakami, Bhubanananda Sahu, Scott J Howell, Songqi Gao, Zhiqian Dong, Marcin Golczak, Akiko Maeda, Krzysztof Palczewski
Age-related macular degeneration (AMD) is a major cause of irreversible vision loss. The neovascular or "wet" form of AMD can be treated to a varying degree with anti-angiogenic drugs, but geographic atrophy (GA) is an advanced stage of the more prevalent "dry" form of AMD for which there is no effective treatment. Development of GA has been linked to loss of the microRNA (miRNA)-processing enzyme DICER1 in the mature retinal pigmented epithelium (RPE). This loss results in the accumulation of toxic transcripts of Alu transposable elements which activate the NLRP3 inflammasome and additional downstream pathways that compromise the integrity and function of the RPE...
January 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28103505/hesperetin-protects-against-h2o2-triggered-oxidative-damage-via-upregulation-of-the-keap1-nrf2-ho-1-signal-pathway-in-arpe-19-cells
#8
Chao Zhu, Yuchen Dong, Haile Liu, Hua Ren, Zhihua Cui
Age-related macular degeneration (AMD) is an irreversible vision loss disease that primarily results from oxidative stress that causes oxidative damage to the retinal pigment epithelial (RPE) cells. Hesperetin (Hesp) is a common flavanone glycoside compound that has been demonstrated to exhibit a variety of biological and pharmacological properties that include anti-inflammatory and antioxidant properties. The aim of this study is to explore the ability of Hesp to attenuate oxidative damage in hydrogen peroxide (H2O2)-stimulated ARPE-19 cells...
January 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28101418/multi-surface-segmentation-of-oct-images-with-amd-using-sparse-high-order-potentials
#9
Jorge Oliveira, Sérgio Pereira, Luís Gonçalves, Manuel Ferreira, Carlos A Silva
In age-related macular degeneration (AMD), the quantification of drusen is important because it is correlated with the evolution of the disease to an advanced stage. Therefore, we propose an algorithm based on a multi-surface framework for the segmentation of the limiting boundaries of drusen: the inner boundary of the retinal pigment epithelium + drusen complex (IRPEDC) and the Bruch's membrane (BM). Several segmentation methods have been considerably successful in segmenting retinal layers of healthy retinas in optical coherence tomography (OCT) images...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28096126/the-age-related-eye-disease-2-study-micronutrients-in-the-treatment-of-macular-degeneration
#10
REVIEW
Aruna Gorusupudi, Kelly Nelson, Paul S Bernstein
Age-related macular degeneration (AMD) is one of the leading causes of vision loss in the elderly. With an increasingly aged population worldwide, the need for the prevention of AMD is rising. Multiple studies investigating AMD with the use of animal models and cell culture have identified oxidative stress-related retinal damage as an important contributing factor. In general, diet is an excellent source of the antioxidants, vitamins, and minerals necessary for healthy living; moreover, the general public is often receptive to recommendations made by physicians and health care workers regarding diet and supplements as a means of empowering themselves to avoid common and worrisome ailments such as AMD, which has made epidemiologists and clinicians enthusiastic about dietary intervention studies...
January 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28095127/association-of-the-dna-repair-smug1-rs3087404-polymorphism-and-its-interaction-with-high-sensitivity-c-reactive-protein-for-age-related-macular-degeneration-in-iranian-patients
#11
Mortaza Bonyadi, Faride Mehdizadeh, Mohammad Hossein Jabbarpoor Bonyadi, Masoud Soheilian, Alireza Javadzadeh, Mehdi Yaseri
BACKGROUND: Age-related macular degeneration (AMD) is a complex disease and recently the role of DNA repairing genes in its susceptibility has been studied. It has been hypothesized that polymorphism in DNA repair system genes reduce the capacity to repair DNA damages which may lead to a greater susceptibility to AMD. C-reactive protein (CRP) production is shown to enhance inflammatory processes by increasing oxidative stress and inducing DNA damage. We planned to evaluate the possible association of SMUG1 variants and their possible interaction with high sensitivity CRP levels in AMD...
January 17, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28095100/association-of-combined-cigarette-smoking-and-arms2-loc387715-a69s-polymorphisms-with-age-related-macular-degeneration-a-meta-analysis
#12
Mohammad Hossein Jabbarpoor Bonyadi, Mehdi Yaseri, Mortaza Bonyadi, Masoud Soheilian, Homayoun Nikkhah
PURPOSE: The age-related maculopathy susceptibility2 (ARMS2)/LOC387715 A69S (rs10490924) polymorphism and cigarette smoking have been shown to have significant association with AMD. In this meta-analysis we used the results of available association studies of combined ARMS2/LOC387715 genotypes and cigarette smoking with AMD to estimate the possible synergistic or multiplicative effects. METHODS: Heterogeneity of studies was evaluated using the Cochran Q-test and the I-square index...
January 17, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28095095/joint-association-of-complement-component-3-and-cc-cytokine-ligand2-ccl2-or-complement-component-3-and-cfh-polymorphisms-in-age-related-macular-degeneration
#13
Mortaza Bonyadi, Mohammad Hossein Jabbarpoor Bonyadi, Mehdi Yaseri, Tahereh Mohammadian, Nikou Fotouhi, Alireza Javadzadeh, Masoud Soheilian
BACKGROUND: To determine the joint effect of complement component 3(C3 R102G) with CC-cytokine ligand2 (CCL2-2518) or complement factor H (CFH) Y402H polymorphisms on advanced age-related macular degeneration (AMD). METHODS: In this case-control study, 233 patients with advanced AMD and 159 unrelated healthy controls enrolled for evaluation. Selected polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphism. RESULTS: A combination of AA CCL2 (rs1024611) and GG C3 (R102G) genotypes resulted in a super-additivity of the risks: OR = 10...
January 17, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28094305/association-of-the-intestinal-microbiome-with-the-development-of-neovascular-age-related-macular-degeneration
#14
Martin S Zinkernagel, Denise C Zysset-Burri, Irene Keller, Lieselotte E Berger, Alexander B Leichtle, Carlo R Largiadèr, Georg M Fiedler, Sebastian Wolf
Age-related macular degeneration (AMD) is the most frequent cause of blindness in the elderly. There is evidence that nutrition, inflammation and genetic risk factors play an important role in the development of AMD. Recent studies suggest that the composition of the intestinal microbiome is associated with metabolic diseases through modulation of inflammation and host metabolism. To investigate whether compositional and functional alterations of the intestinal microbiome are associated with AMD, we sequenced the gut metagenomes of patients with AMD and controls...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28092343/natural-course-of-patients-discontinuing-treatment-for-age-related-macular-degeneration-and-factors-associated-with-visual-prognosis
#15
Jae Hui Kim, Young Suk Chang, Jong Woo Kim
PURPOSE: To evaluate the 24-month natural course of visual changes in patients discontinuing treatment despite persistent or recurrent fluid and factors predictive of visual prognosis. METHODS: This retrospective, observational study included 35 patients (35 eyes) who initially received anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration (AMD), but discontinued treatment despite persistent or recurrent fluid. The best-corrected visual acuity (BCVA) at treatment discontinuation was determined and compared with the 24-month BCVA, which was then compared between polypoidal choroidal vasculopathy and other neovascular age-related macular degeneration subtypes...
January 13, 2017: Retina
https://www.readbyqxmd.com/read/28091996/zeolitic-tuffs-for-acid-mine-drainage-amd-treatment-in-ecuador-breakthrough-curves-for-mn-2-cd-2-cr-3-zn-2-and-al-3
#16
Xavier Buenaño, Laureano Canoira, Domingo Martin Sánchez, Jorge Costafreda
Zeolitic tuff constitutes a technical and economical feasible alternative to manage acidic waters in initial phases of generation. A study of cation exchange with two zeolitic tuffs from Ecuador and one from Cuba has been conducted using breakthrough curve methodology. Cations Mn(2+), Cd(2+), Cr(3+), Zn(2+), and Al(3+) have been chosen owing to their presence in underground water in exploration activities (decline development) in Fruta del Norte (Ecuador). Zeolites characterized by X-ray diffraction and thermal stability after heating overnight as heulandites show a similar exchange behavior for the five cations studied...
January 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28091406/awareness-of-age-related-macular-degeneration-and-its-risk-factors-among-beijing-residents-in-china
#17
Chen-Xi Zhang, Gu-Muyang Zhang, Nan Ma, Song Xia, Jing-Yuan Yang, You-Xin Chen
BACKGROUND: Age-related macular degeneration (AMD) is a major cause of irreversible blindness, and awareness of this disease is important in the prevention of blindness. However, lack of public awareness of AMD was shown in previous studies, and there was no report of AMD awareness in the Mainland of China. Therefore, the aim of our study was to assess the awareness of AMD and its risk factors among Beijing residents in China. METHODS: A cross-sectional, computer-assisted, telephone investigation was conducted to measure the awareness of AMD among Beijing residents...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28089680/peripheral-retinal-changes-associated-with%C3%A2-age-related-macular-degeneration-in%C3%A2-the-age-related-eye-disease-study-2-age-related-eye-disease-study-2-report-number-12-by-the%C3%A2-age-related-eye-disease-study-2-optos-peripheral-retina-opera-study-research-group
#18
Amitha Domalpally, Traci E Clemons, Ronald P Danis, SriniVas R Sadda, Catherine A Cukras, Cynthia A Toth, Thomas R Friberg, Emily Y Chew
PURPOSE: To compare rates of peripheral retinal changes in Age-Related Eye Disease Study 2 (AREDS2) participants with at least intermediate age-related macular degeneration (AMD) with control subjects without intermediate age-related changes (large drusen). DESIGN: Cross-sectional evaluation of clinic-based patients enrolled in AREDS2 and a prospective study. PARTICIPANTS: Participants from prospective studies. METHODS: The 200° pseudocolor and fundus autofluorescence (FAF) images were captured on the Optos 200 Tx Ultrawide-field device (Optos, Dunfermline, Scotland) by centering on the fovea and then steering superiorly and inferiorly...
January 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28089331/evaluation-of-marginal-and-internal-adaptation-of-hybrid-and-nanoceramic-systems-with-microcomputed-tomography-an-in%C3%A2-vitro-study
#19
Güler Yildirim, Ismail H Uzun, Ali Keles
STATEMENT OF PROBLEM: The accuracy of recently introduced chairside computer-aided design and computer-aided manufacturing (CAD-CAM) blocks is not well established, and marginal integrity and internal adaptation are not known. PURPOSE: The purpose of this in vitro study was to evaluate the marginal and internal adaptation of hybrid and nanoceramics using microcomputed tomography (μ-CT). MATERIAL AND METHODS: The marginal and internal adaptation of 3 polymer-infiltrated ceramic-network (PICN) materials (Vita Enamic [VE]; Lava Ultimate [LU]; Vita Suprinity [VS]) were compared with lithium disilicate (IPS e...
January 12, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28088549/redistribution-of-elements-between-wastes-and-organic-bearing-material-in-the-dispersion-train-of-gold-bearing-sulfide-tailings-part-i-geochemistry-and-mineralogy
#20
B Yu Saryg-Ool, I N Myagkaya, I S Kirichenko, M A Gustaytis, O V Shuvaeva, S M Zhmodik, E V Lazareva
Migration and redistribution of elements during prolonged interaction of cyanide wastes with the underlying natural organic-bearing material have been studied in two ~40cm deep cores that sample primary ores and their weathering profile (wastes I and II, respectively) in the dispersion train of gold-bearing sulfide tailings in Siberia. Analytical results of SR-XRF, whole-rock XRF, AAS, CHNS, and SEM measurements of core samples show high K, Sr, Ti, and Fe enrichments and correlation of P2O5 and Mn with LOI and Corg...
January 11, 2017: Science of the Total Environment
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