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https://www.readbyqxmd.com/read/28231566/one-year-outcomes-of-1-pro-re-nata-versus-3-pro-re-nata-intravitreal-aflibercept-injection-for-neovascular-age-related-macular-degeneration
#1
Kei Takayama, Hiroki Kaneko, Tadasu Sugita, Ruka Maruko, Kyoko Hattori, Eimei Ra, Kenichi Kawano, Keiko Kataoka, Yasuki Ito, Hiroko Terasaki
PURPOSE: We compared 1-year outcomes of 1 + pro re nata (PRN) versus 3 + PRN of intravitreal aflibercept injection (IAI) for age-related macular degeneration (AMD). METHODS: Forty-two eyes with naïve AMD received 3 + PRN IAI treatment and 47 eyes with naïve AMD received 1 + PRN IAI treatment. Visual acuity (VA), central retinal thickness (CRT), and central choroidal thickness (CCT) and number of administered IAIs during 12 months were compared. RESULTS: VAs improved, and CRTs reduced significantly at any given month from baseline in both groups (p < 0...
February 24, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28228282/complement-factor-h-inhibits-cd47-mediated-resolution-of-inflammation
#2
Bertrand Calippe, Sebastien Augustin, Fanny Beguier, Hugo Charles-Messance, Lucie Poupel, Jean-Baptiste Conart, Shulong J Hu, Sophie Lavalette, Alexandre Fauvet, Julie Rayes, Olivier Levy, William Raoul, Catherine Fitting, Thomas Denèfle, Matthew C Pickering, Claire Harris, Sylvie Jorieux, Patrick M Sullivan, José-Alain Sahel, Philippe Karoyan, Przemyslaw Sapieha, Xavier Guillonneau, Emmanuel L Gautier, Florian Sennlaub
Variants of the CFH gene, encoding complement factor H (CFH), show strong association with age-related macular degeneration (AMD), a major cause of blindness. Here, we used murine models of AMD to examine the contribution of CFH to disease etiology. Cfh deletion protected the mice from the pathogenic subretinal accumulation of mononuclear phagocytes (MP) that characterize AMD and showed accelerated resolution of inflammation. MP persistence arose secondary to binding of CFH to CD11b, which obstructed the homeostatic elimination of MPs from the subretinal space mediated by thrombospsondin-1 (TSP-1) activation of CD47...
February 21, 2017: Immunity
https://www.readbyqxmd.com/read/28228273/compliments-of-factor-h-what-s-in-it-for-amd
#3
Mary J Mattapallil, Rachel R Caspi
Genetic variations in complement factor H (CFH) confer greater risk for age-related macular degeneration (AMD). In this issue of Immunity, Calippe et al. (2017) uncover a non-canonical role for CFH in the inhibition of mononuclear phagocyte elimination from sub-retinal lesions, providing insight into the pathophysiology of AMD associated with CFH variants.
February 21, 2017: Immunity
https://www.readbyqxmd.com/read/28227879/wearable-diagnostic-system-for-age-related-macular-degeneration
#4
N Mohaghegh, E Ghafar Zadeh, S Magierowski, N Mohaghegh, E Ghafar Zadeh, S Magierowski, N Mohaghegh, E Ghafar Zadeh, S Magierowski
This paper presents a novel head-mounted point-of-care diagnostic system for detection and continuous monitoring of Age-related Macular Degeneration (AMD). This wearable embedded open-source platform enables accurate monitoring of AMD by taking advantage of multiple standard graphical interface techniques such as Amsler Grid, Threshold Amsler Grid, Macular Computerized Psychophysical Test and Preferential Hyperacuity Perimeter (PHP). Here, we describe the proposed multi-Grid or so-called NGRID software and elaborate on the hardware prototype...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226753/determining-the-difference-in-eyegaze-measurements-in-individuals-with-age-related-macular-degeneration
#5
Huiying Liu, Damon Wong, Ai Ping Yow, Yanwu Xu, Fengshou Yin, Augustinus Laude, Tock Han Lim, Huiying Liu, Damon Wong, Ai Ping Yow, Yanwu Xu, Fengshou Yin, Augustinus Laude, Tock Han Lim, Augustinus Laude, Huiying Liu, Tock Han Lim, Fengshou Yin, Yanwu Xu, Damon Wong, Ai Ping Yow
Age-related Macular Degeneration (AMD) is one of the leading causes of blindness in the elderly. Visual loss associated with AMD often results in a central scotoma which is an alteration in the central vision, leading to distortion or loss of vision. Current methods of detecting AMD are typically manual, require holding fixation and an external response trigger. In this paper, we propose the use of eyegaze tracking to detect for the presence of AMD, using a simple set of test patterns. Experimental results show that the derived eyegaze measurements can help to identify individuals with AMD from healthy individuals...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226737/4d-lung-tumor-segmentation-via-shape-prior-and-motion-cues
#6
Jung Won Cha, Mohammad M Farhangi, Neal Dunlap, Amir Amini, Jung Won Cha, Mohammad M Farhangi, Neal Dunlap, Amir Amini, Jung Won Cha, Amir Amini, Neal Dunlap, Mohammad M Farhangi
Lung tumor segmentation is important for therapy in the radiation treatment of patients with thoracic malignancies. In this paper, we describe a 4D image segmentation method based on graph-cuts optimization, shape prior and optical flow. Due to small size, the location, and low contrast between the tumor and the surrounding tissue, tumor segmentation in 3D+t is challenging. We performed 4D lung tumor segmentation in 5 patients, and in each case compared the results with the expert-delineated lung nodules. In each case, 4D image segmentation took approximately ten minutes on a PC with AMD Phenom II and 32GB of memory for segmenting tumor in five phases of lung CT data...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225371/measurement-of-perceived-stress-in-age-related-macular-degeneration
#7
Bradley E Dougherty, San-San L Cooley, Frederick H Davidorf
PURPOSE: To validate the Perceived Stress Scale (PSS) in patients with age-related macular degeneration (AMD) using Rasch analysis. METHODS: Study participants with AMD were recruited from the retina service of the Department of Ophthalmology at the Ohio State University during clinical visits for treatment or observation. Visual acuity with habitual distance correction was assessed. A 10-item version of the PSS was administered in large print or by reading the items to the patient...
March 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28223776/idiopathic-polypoidal-choroidal-vasculopathy-in-thai-patients-with-clinical-and-angiographic-choroidal-neovascularization
#8
Chavakij Bhoomibunchoo, Yosanan Yospaiboon, Somanus Thoongsuwan, Duangnate Rojanaporn, Nawat Watanachai, Pichai Jirarattanasopa, Nattapon Wongcumchang, Atchara Amphornphruet, Sritatath Vongkulsiri, Eakkachai Arayangkoon
OBJECTIVE: This study aimed to study the prevalence and characteristics of idiopathic polypoidal choroidal vasculopathy (IPCV) in Thai patients with clinical and angiographic choroidal neovascularization (CNV). PATIENTS AND METHODS: A consecutive case study of 140 patients presenting with CNV was conducted in nine large referral eye centers throughout Thailand. The demographic data, fundus photographs, fundus fluorescein angiography and indocyanine green angiography of the patients were analyzed...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28223209/langmuir-schaefer-film-deposition-onto-honeycomb-porous-films-for-retinal-tissue-engineering
#9
Maria Teresa Calejo, Tanja Ilmarinen, Elina Vuorimaa-Laukkanen, Elina Talvitie, Hanna M Hakola, Heli Skottman, Minna Kellomäki
: Age-related macular degeneration (AMD) is the leading cause of vision loss in senior citizens in the developed world. The disease is characterised by the degeneration of a specific cell layer at the back of the eye - the retinal pigment epithelium (RPE), which is essential in retinal function. The most promising therapeutic option to restore the lost vision is considered to be RPE cell transplantation. This work focuses on the development of biodegradable biomaterials with similar properties to the native Bruch's membrane as carriers for RPE cells...
February 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28222108/oxidative-stress-mediated-nf%C3%AE%C2%BAb-phosphorylation-upregulates-p62-sqstm1-and-promotes-retinal-pigmented-epithelial-cell-survival-through-increased-autophagy
#10
Chunjuan Song, Sayak K Mitter, Xiaoping Qi, Eleni Beli, Haripriya V Rao, Jindong Ding, Colin S Ip, Hongmei Gu, Debra Akin, William A Dunn, Catherine Bowes Rickman, Alfred S Lewin, Maria B Grant, Michael E Boulton
p62 is a scaffolding adaptor implicated in the clearance of protein aggregates by autophagy. Reactive oxygen species (ROS) can either stimulate or inhibit NFκB-mediated gene expression influencing cellular fate. We studied the effect of hydrogen peroxide (H2O2)-mediated oxidative stress and NFκB signaling on p62 expression in the retinal pigment epithelium (RPE) and investigated its role in regulation of autophagy and RPE survival against oxidative damage. Cultured human RPE cell line ARPE-19 and primary human adult and fetal RPE cells were exposed to H2O2-induced oxidative stress...
2017: PloS One
https://www.readbyqxmd.com/read/28214102/vitreomacular-adhesion-and-the-risk-of-neovascular-age-related-macular-degeneration
#11
Emilia Maggio, Antonio Polito, Massimo Guerriero, Guido Prigione, Barbara Parolini, Grazia Pertile
PURPOSE: To assess the prevalence of vitreomacular adhesion (VMA) in consecutive naïve eyes diagnosed with exudative age-related macular degeneration (AMD) in comparison with eyes with nonexudative AMD and age-matched controls, and to evaluate prospectively the incidence of vitreomacular interface changes over time and their influence on choroidal neovascularization (CNV) development. DESIGN: Retrospective cross-sectional analysis and longitudinal cohort study conducted at Sacrocuore Hospital, Negrar, Verona, Italy...
February 14, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28212183/cxcl12-cxcr4-signaling-contributes-to-the-pathogenesis-of-opioid-tolerance-a-translational-study
#12
Chih-Peng Lin, Kai-Hsiang Kang, Huang-Ju Tu, Ming-Yueh Wu, Tzu-Hung Lin, Houng-Chi Liou, Wei-Zen Sun, Wen-Mei Fu
BACKGROUND: Long-term opioid therapy for chronic pain may lead to analgesic tolerance, especially when administered intrathecally, thus preventing adequate pain relief. Discovering drug targets to treat opioid tolerance using a mechanism-based approach targeting opioid-induced neuroinflammation provides new therapeutic opportunities. In this study, we provide translational evidence that CXCL12/CXCR4 signaling contributes to the pathogenesis of opioid tolerance. METHODS: The CXCL12 levels in the cerebrospinal fluid of opioid-tolerant patients were compared with those of opioid-naive subjects...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28209587/genome-surgery-using-cas9-ribonucleoproteins-for-the-treatment-of-age-related-macular-degeneration
#13
Kyoungmi Kim, Sung Wook Park, Jin Hyoung Kim, Seung Hwan Lee, Daesik Kim, Taeyoung Koo, Kwang-Eun Kim, Jeong Hun Kim, Jin-Soo Kim
RNA-guided genome surgery using CRISPR-Cas9 nucleases has shown promise for the treatment of diverse genetic diseases. Yet, the potential of such nucleases for therapeutic applications in nongenetic diseases is largely unexplored. Here, we focus on age-related macular degeneration (AMD), a leading cause of blindness in adults, which is associated with retinal overexpression of, rather than mutations in, the VEGFA gene. Subretinal injection of preassembled, Vegfa gene-specific Cas9 ribonucleoproteins (RNPs) into the adult mouse eye gave rise to mutagenesis at the target site in the retinal pigment epithelium...
February 16, 2017: Genome Research
https://www.readbyqxmd.com/read/28208784/lutein%C3%A2-and%C3%A2-zeaxanthin-food%C3%A2-sources-%C3%A2-bioavailability%C3%A2-and%C3%A2-dietary%C3%A2-variety%C3%A2-in%C3%A2-age-related%C3%A2-macular%C3%A2-degeneration%C3%A2-protection
#14
REVIEW
Bronwyn Eisenhauer, Sharon Natoli, Gerald Liew, Victoria M Flood
Lutein and zeaxanthin (L/Z) are the predominant carotenoids which accumulate in the retina of  the eye. The impact of L/Z intake on the risk and progression of age-related macular degeneration (AMD),  a leading cause of blindness in the developed world, has been investigated in cohort studies and clinical  trials. The aims of this review were to critically examine the literature and evaluate the current evidence  relating to L/Z intake and AMD, and describe important food sources and factors that increase the  bioavailability of L/Z, to inform dietary models...
February 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28206671/surgery-for-cataracts-in-people-with-age-related-macular-degeneration
#15
REVIEW
Heather Casparis, Kristina Lindsley, Irene C Kuo, Shameema Sikder, Neil M Bressler
BACKGROUND: Cataract and age-related macular degeneration (AMD) are common causes of decreased vision that often occur simultaneously in people over age 50. Although cataract surgery is an effective treatment for cataract-induced visual loss, some clinicians suspect that such an intervention may increase the risk of worsening of underlying AMD and thus have deleterious effects on vision. OBJECTIVES: The objective of this review was to evaluate the effectiveness and safety of cataract surgery compared with no surgery in eyes with AMD...
February 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28202390/systemic-injection-of-rpe65-programmed-bone-marrow-derived-cells-prevents-progression-of-chronic-retinal-degeneration
#16
Xiaoping Qi, S Louise Pay, Yuanqing Yan, James Thomas, Alfred S Lewin, Lung-Ji Chang, Maria B Grant, Michael E Boulton
Bone marrow stem and progenitor cells can differentiate into a range of non-hematopoietic cell types, including retinal pigment epithelium (RPE)-like cells. In this study, we programmed bone marrow-derived cells (BMDCs) ex vivo by inserting a stable RPE65 transgene using a lentiviral vector. We tested the efficacy of systemically administered RPE65-programmed BMDCs to prevent visual loss in the superoxide dismutase 2 knockdown (Sod2 KD) mouse model of age-related macular degeneration. Here, we present evidence that these RPE65-programmed BMDCs are recruited to the subretinal space, where they repopulate the RPE layer, preserve the photoreceptor layer, retain the thickness of the neural retina, reduce lipofuscin granule formation, and suppress microgliosis...
February 12, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28197357/disturbed-matrix-metalloproteinase-pathway-in-both-age-related-macular-degeneration-and-alzheimer-s-disease
#17
Ali Aijaz Hussain, Yunhee Lee, Jin-Jun Zhang, Paul T Francis, John Marshall
Purpose. Abnormal protein deposits including β-amyloid, found in ageing Bruch's membrane and brain, are susceptible to degradation by matrix metalloproteinases (MMPs). In ageing Bruch's membrane, these MMPs become less effective due to polymerisation and aggregation reactions (constituting the MMP Pathway), a situation much advanced in age-related macular degeneration (AMD). The likely presence of this MMP Pathway in brain with the potential to compromise the degradation of β-amyloid associated with Alzheimer's disease (AD) has been investigated...
2017: Journal of Neurodegenerative Diseases
https://www.readbyqxmd.com/read/28196945/healthcare-experiences-of-patients-with-age-related-macular-degeneration-have-things-improved-cross-sectional-survey-responses-of-macular-society-members-in-2013-compared-with-1999
#18
Emily M Boxell, Winfried M Amoaku, Clare Bradley
OBJECTIVE: To investigate healthcare experiences of patients with age-related macular degeneration (AMD) and determine whether a previous survey and Royal College of Ophthalmologists (RCOphth) management guidelines brought improvements. DESIGN: Cross-sectional survey of Macular Society members in 2013 compared with previous 1999 survey. SETTING: UK Postal Questionnaires. PARTICIPANTS: 1169 respondents in 2013 (1187 in 1999)...
February 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28196060/angiographic-subtypes-of-polypoidal-choroidal-vasculopathy-in-taiwan-a-prospective-multicenter-study
#19
Ling Yeung, Chien-Neng Kuo, An-Ning Chao, Kuan-Jen Chen, Wei-Chi Wu, Chien-Hsiung Lai, Nan-Kai Wang, Yih-Shiou Hwang, Ching-Lung Chen, Chi-Chun Lai
PURPOSE: To determine the incidence and clinical characteristics of angiographic subtypes of polypoidal choroidal vasculopathy (PCV). METHODS: It is a prospective, multicenter, cross-sectional study. Patients with newly diagnosed exudative macular degeneration are classified into PCV, age-related macular degeneration (AMD), and retinal angiomatous proliferation. Polypoidal choroidal vasculopathy is further classified into two subtypes depending on the presence (Type 1: polypoidal choroidal neovascularization) or absence (Type 2: typical PCV) of feeder vessels on indocyanine green angiography...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28195603/classification-of-exudative-age-related-macular-degeneration-with-pachyvessels-on-en-face-swept-source-optical-coherence-tomography
#20
Danny Siu-Chun Ng, Malini Bakthavatsalam, Frank Hiu-Ping Lai, Carol Yim-Lui Cheung, Gemmy Chu-Ming Cheung, Fang Yao Tang, Chi Wai Tsang, Timothy Yuk-Yau Lai, Tien Yin Wong, Mårten Erik Brelén
Purpose: The purpose of this study was to classify exudative maculopathy by the presence of pachyvessels on en face swept-source optical coherence tomography (SSOCT). Methods: Consecutive patients with signs of exudative maculopathy underwent SSOCT, fluorescein and indocyanine green angiography (ICGA), ultra-widefield fundus color photography, and autofluorescence examinations. Images were analyzed in a masked fashion by two sets of four examiners in different sessions: (1) the presence of pachyvessels in en face OCT and (2) features of exudative maculopathy in conventional imaging modalities...
February 1, 2017: Investigative Ophthalmology & Visual Science
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