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https://www.readbyqxmd.com/read/29667051/performance-assessment-of-laboratory-and-field-scale-multi-step-passive-treatment-of-iron-rich-acid-mine-drainage-for-design-improvement
#1
Tsiverihasina V Rakotonimaro, Carmen Mihaela Neculita, Bruno Bussière, Thomas Genty, Gérald J Zagury
Multi-step passive systems for the treatment of iron-rich acid mine drainage (Fe-rich AMD) perform satisfactorily at the laboratory scale. However, their field-scale application has revealed dissimilarities in performance, particularly with respect to hydraulic parameters. In this study, the assessment of factors potentially responsible for the variations in performance of laboratory and field-scale multi-step systems was undertaken. Three laboratory multi-step treatment scenarios, involving a combination of dispersed alkaline substrate (DAS) units, anoxic dolomitic drains, and passive biochemical reactors (PBRs), were set up in 10...
April 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29666476/hif1a-inactivation-rescues-photoreceptor-degeneration-induced-by-a-chronic-hypoxia-like-stress
#2
Maya Barben, Divya Ail, Federica Storti, Katrin Klee, Christian Schori, Marijana Samardzija, Stylianos Michalakis, Martin Biel, Isabelle Meneau, Frank Blaser, Daniel Barthelmes, Christian Grimm
Reduced choroidal blood flow and tissue changes in the ageing human eye impair oxygen delivery to photoreceptors and the retinal pigment epithelium. As a consequence, mild but chronic hypoxia may develop and disturb cell metabolism, function and ultimately survival, potentially contributing to retinal pathologies such as age-related macular degeneration (AMD). Here, we show that several hypoxia-inducible genes were expressed at higher levels in the aged human retina suggesting increased activity of hypoxia-inducible transcription factors (HIFs) during the physiological ageing process...
April 17, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29666126/domains-of-health-related-quality-of-life-in-age-related-macular-degeneration-a-qualitative-study-in-the-chinese-cultural-context
#3
Wei Bian, Junli Wan, Graeme Smith, Shiying Li, Mingqiong Tan, Fengjiao Zhou
OBJECTIVE: To explore which areas of health-related quality of life were affected in Chinese patients, and to identify whether the areas are well covered by validated questionnaires. DESIGN: A qualitative study based on semistructured interviews was conducted. A qualitative thematic analysis following the approach of Colaizzi was used to analyse the interview data for significant statements and phrases. The themes and subthemes organised from the analysis were then compared by using the following current instruments: National Eye Institute Visual Function Questionnaire (NEI-VFQ-25), Macular Disease Quality of life Questionnaire (MacDQoL) and Low-Luminance Questionnaire (LLD)...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29666051/female-drosophila-melanogaster-respond-to-song-amplitude-modulations
#4
Birgit Brüggemeier, Mason A Porter, Jim O Vigoreaux, Stephen F Goodwin
Males in numerous animal species use mating songs to attract females and intimidate competitors. We demonstrate that modulations in song amplitude are behaviourally relevant in the fruit fly Drosophila We show that D. melanogaster females prefer amplitude modulations typical of melanogaster song over other modulations, which suggests that amplitude modulations are processed auditorily by D. melanogaster Our work demonstrates that receivers can decode messages in amplitude modulations, complementing the recent finding that male flies actively control song amplitude...
April 17, 2018: Biology Open
https://www.readbyqxmd.com/read/29664944/ccl2-single-nucleotide-polymorphism-of-rs1024611-implicates-prominence-of-inflammatory-cascade-by-univariate-modeling-in-indian-amd
#5
Neel Kamal Sharma, Kaushal Sharma, Ramandeep Singh, Suresh Kumar Sharma, Akshay Anand
BACKGROUND: The role of chemotactic protein CCL2/MCP-1 has been widely explored in age related macular degeneration (AMD) patients as well as animal models through our previous studies. AIM: Aim of the study was to examine the association of another variance of CCL2, rs1024611 in pathophysiology of AMD. METHODS: This particular SNP has been found to be involved in inflammatory processes in various diseases. Total 171 subjects were recruited in the study with all demographic details by administering a standard questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29664159/reading-aids-for-adults-with-low-vision
#6
REVIEW
Gianni Virgili, Ruthy Acosta, Sharon A Bentley, Giovanni Giacomelli, Claire Allcock, Jennifer R Evans
BACKGROUND: The purpose of low-vision rehabilitation is to allow people to resume or to continue to perform daily living tasks, with reading being one of the most important. This is achieved by providing appropriate optical devices and special training in the use of residual-vision and low-vision aids, which range from simple optical magnifiers to high-magnification video magnifiers. OBJECTIVES: To assess the effects of different visual reading aids for adults with low vision...
April 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29663086/marginal-adaptation-of-lithium-disilicate-ceramic-crowns-cemented-with-three-different-resin-cements
#7
Ingrid Peroz, Triantafyllos Mitsas, Kurt Erdelt, Niko Kopsahilis
OBJECTIVES: The cementation process and cementation materials have an influence on the marginal adaptation of restorations. The gap could be affected by thermal and mechanical loading (TCML). The computerized x-ray microtomography (μCT) method offers the possibility of measuring the marginal gap without destruction of the restoration. The aim of this study was to evaluate the marginal gap (MG) and the absolute marginal discrepancy (AMD) before and after TCML. MATERIALS AND METHODS: Thirty-nine human premolars were prepared for full ceramic crowns made of lithium disilicate...
April 17, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29661534/a-new-chlorin-formulation-promotes-efficient-photodynamic-action-in-choriocapillaris-of-rabbit-s-eyes
#8
Gustavo H A Salomao, Adjaci U Fernandes, Mauricio S Baptista, João Paulo Tardivo, Stella Gianssante, Juliana Mora Veridiano, Olga Maria S Toledo, Giuliana Petri, Denise Maria Christofolini, João Antonio Correa
Age-related macular degeneration (AMD) as well as other choroidal diseases, demand novel therapeutic methods. Photodynamic therapy (PDT), which uses light and photosensitizer (PS) to cause specific vascular occlusion in the macula, is an interesting alternative. The only drug approved for the PDT treatment of AMD (Verteporfin) has a natural tendency to aggregate, demanding an expensive separation procedure during purification. We report a novel and affordable PS that is intrinsically protected against aggregation, the Monomeric Chlorin at High Concentration (MCHC-Chlorin), whose liposomal formulation was developed to provoke effective photodynamic action on the choroidal vasculature...
April 4, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29660843/mortality-after-a-cerebrovascular-event-in-age-related-macular-degeneration-patients-treated-with-bevacizumab-ocular-injections
#9
Joel Hanhart, Doron S Comaneshter, Shlomo Vinker
PURPOSE: To analyse the mortality associated with intravitreal injections of bevacizumab for age-related macular degeneration (AMD) in patients previously diagnosed with stroke or transient ischaemic attack (TIA). METHODS: We reviewed bevacizumab-treated AMD patients with a diagnosis of stroke or TIA prior to their first bevacizumab injection (n = 948). Those patients, naïve to any anti-vascular endothelial growth factor (anti-VEGF) at the time of stroke/TIA, were then compared to age- and gender-matched patients who had a stroke/TIA at the same time and had never been exposed to anti-VEGF...
April 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29655642/estimating-medicare-and-patient-savings-from-the-use-of-bevacizumab-for-the-treatment-of-exudative-age-related-macular-degeneration
#10
Philip J Rosenfeld, Matthew A Windsor, William J Feuer, Sissi J J Sun, Kevin D Frick, Eric A Swanson, David Huang
PURPOSE: The Medicare cost savings from the use of bevacizumab in the United States for the treatment of exudative age-related macular degeneration (AMD) were estimated by replacing the use of bevacizumab with ranibizumab and aflibercept. DESIGN: Retrospective trend study. METHODS: Main outcome measures were spending by Medicare as tracked by Current Procedural Terminology (CPT) codes for intravitreal injections (67028) and treatment-specific J-codes (J0178, J2778, J9035, J3490 and J3590) for inhibitors of vascular endothelial growth factor...
April 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29651346/choriocapillaris-loss-in-advanced-age-related-macular-degeneration
#11
REVIEW
Carlos A Moreira-Neto, Eric M Moult, James G Fujimoto, Nadia K Waheed, Daniela Ferrara
The purpose of this review is to summarize the current knowledge on choriocapillaris loss in advanced age macular degeneration (AMD). Several histopathological studies in animal models and human eyes had showed that the choriocapillaris density decreases with age. However, the role of choriocapillaris loss is still unclear in AMD and its advanced forms, either choroidal neovascularization (CNV) or geographic atrophy (GA). Some authors have hypothesized that choriocapillaris loss might precede overt retinal pigment epithelium atrophy...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29650998/a-mega-analysis-of-expression-quantitative-trait-loci-eqtl-provides-insight-into-the-regulatory-architecture-of-gene-expression-variation-in-liver
#12
Tobias Strunz, Felix Grassmann, Javier Gayán, Satu Nahkuri, Debora Souza-Costa, Cyrille Maugeais, Sascha Fauser, Everson Nogoceke, Bernhard H F Weber
Genome-wide association studies (GWAS) have identified numerous genetic variants in the human genome associated with diseases and traits. Nevertheless, for most loci the causative variant is still unknown. Expression quantitative trait loci (eQTL) in disease relevant tissues is an excellent approach to correlate genetic association with gene expression. While liver is the primary site of gene transcription for two pathways relevant to age-related macular degeneration (AMD), namely the complement system and cholesterol metabolism, we explored the contribution of AMD associated variants to modulate liver gene expression...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650974/publisher-correction-predictors-of-chronic-kidney-disease-in-type-1-diabetes-a-longitudinal-study-from-the-amd-annals-initiative
#13
Pamela Piscitelli, Francesca Viazzi, Paola Fioretto, Carlo Giorda, Antonio Ceriello, Stefano Genovese, Giuseppina Russo, Pietro Guida, Roberto Pontremoli, Salvatore De Cosmo
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29648831/the-molecular-mechanism-behind-resistance-of-the-g1202r-mutated-anaplastic-lymphoma-kinase-to-the-approved-drug-ceritinib
#14
Chaohong Chen, Zhifeng He, Deyao Xie, Liangcheng Zheng, Tianhao Zhao, Xinbo Zhang, Dezhi Cheng
Anaplastic lymphoma kinase (ALK) has been regarded as an essential target for the treatment of non-small cell lung cancer (NSCLC). However, the emergence of G1202R solvent front mutation that confer resistance to the drugs were reported for the first as well as the second generation ALK inhibitors. It was supposed that the G1202R solvent front mutation might hinder the drug binding. In this study, a different fact could be clarified by multiple molecular modeling methodologies through a structural analogue of ceritinib (compound 10, Cpd-10) that is reported to be a potent inhibitor against the G1202R mutation...
April 12, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29627466/a-polysaccharide-from-green-tea-camellia-sinensis-l-protects-human-retinal-endothelial-cells-against-hydrogen-peroxide-induced-oxidative-injury-and-apoptosis
#15
Yitao Yan, Yanfan Ren, Xinmin Li, Xinxia Zhang, Huiqing Guo, Yutong Han, Junxi Hu
Oxidative damage of retinal pigment epithelium (RPE) cells is involved in the pathogenesis age related macular degeneration (AMD). The purpose of this study was to evaluate the potential protective effect of a purified green tea polysaccharide (GTWP) against hydrogen peroxide (H2 O2 ) induced oxidative stress and apoptosis in human retinal pigment epithelial cells (ARPE-19 cells). Human ARPE-19 cells were treated with 1 h of 500 μM H2 O2 before incubation with GTWP for 24 h. Pretreatment of GTWP decreased H2 O2 -induced cell death and cell apoptosis, and efficiently suppressed the intracellular ROS production and malondialdehyde (MDA) generation induced by H2 O2 treatment...
April 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29625839/choroidal-and-sub-retinal-pigment-epithelium-caverns-multimodal-imaging-and-correspondence-with-friedman-lipid-globules
#16
Rosa Dolz-Marco, Jay P Glover, Orly Gal-Or, Katie M Litts, Jeffrey D Messinger, Yuhua Zhang, Mariano Cozzi, Marco Pellegrini, K Bailey Freund, Giovanni Staurenghi, Christine A Curcio
PURPOSE: To survey Friedman lipid globules by high-resolution histologic examination and to compare with multimodal imaging of hyporeflective caverns in eyes with geographic atrophy (GA) secondary to age-related macular (AMD) and other retinal diseases. DESIGN: Histologic survey of donor eyes with and without AMD. Clinical case series with multimodal imaging analysis. PARTICIPANTS: Donor eyes (n = 139; 26 with early AMD, 13 with GA, 40 with nAMD, 52 with a healthy macula, and 8 with other or unknown characteristics) and 41 eyes of 28 participants with GA (n = 16), nAMD (n = 8), Stargardt disease (n = 4), cone dystrophy (n = 2), pachychoroid spectrum (n = 6), choroidal hemangioma (n = 1), and healthy eyes (n = 4)...
April 3, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29625486/structure-function-analysis-in-patients-with-intermediate-age-related-macular-degeneration
#17
Marlene Saßmannshausen, Julia S Steinberg, Rolf Fimmers, Maximilian Pfau, Sarah Thiele, Monika Fleckenstein, Frank G Holz, Steffen Schmitz-Valckenberg
Purpose: To examine the topographic correlation between retinal morphology and retinal sensitivity by mesopic and scotopic fundus-controlled perimetry (FCP) in eyes with intermediate AMD. Methods: Thirty-five eyes from 32 patients (mean age 70.9 years) and 29 age-matched controls prospectively underwent spectral-domain optical coherence tomography (SD-OCT) imaging. Mesopic (Goldman III, 200 ms, 4-2 strategy) and scotopic (Goldman V, 200 ms, 4-2 strategy) FCP with a 56-stimulus point grid was performed in AMD patients with the MP-1S...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625463/taurine-depletion-causes-iprgc-loss-and-increases-light-induced-photoreceptor-degeneration
#18
Diego García-Ayuso, Johnny Di Pierdomenico, Wahiba Hadj-Said, Mélanie Marie, Marta Agudo-Barriuso, Manuel Vidal-Sanz, Serge Picaud, María P Villegas-Pérez
Purpose: To examine if light exposure exacerbates retinal neuronal loss induced by taurine depletion. Methods: Albino rats received β-alanine in the drinking water to induce taurine depletion. One month later, half of the animals were exposed to white light (3000 lux) continuously for 48 hours and the rest remained in normal environmental conditions. A control group of animals nontreated with β-alanine also was prepared, and half of them were exposed to light using the same protocol...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625455/release-of-different-cell-mediators-during-retinal-pigment-epithelium-regeneration-following-selective-retina-therapy
#19
Elisabeth Richert, Stefan Koinzer, Jan Tode, Kerstin Schlott, Ralf Brinkmann, Jost Hillenkamp, Alexa Klettner, Johann Roider
Purpose: To investigate the effect of selective retina therapy (SRT) on the release of AMD-relevant cell mediators, such as matrix metalloproteinases (MMPs), VEGF, and pigment epithelium derived factor (PEDF) using different laser spot sizes and densities. Methods: Porcine RPE-choroid explants were treated with a pulsed 532 nm Nd:YAG laser using (1) large spot sizes, (2) small spot sizes with a high-density (hd) treatment, and (3) small spot sizes with a low-density (ld) treatment...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625396/tolerance-of-ulothrix-sp-lafic-010-chlorophyta-against-high-concentration-of-metals-from-acid-mine-drainage
#20
T F Massocato, J C Ramos, V L F Bascuñan, C Simioni, L R Rörig, J Bonomi Barufi
The production of acid mine drainage of (AMD) is one of the main phenomena responsible for much of the degradation of water and soil resources. Organisms present at sites contaminated by AMD can have the potential to bioaccumulate heavy metals, stimulating their application in bioremediation processes. Ulothrix sp. LAFIC 010 was identified among the species of algae isolated from water contaminated by AMD in the region of Sideropólis (Brazil). The present study evaluated its tolerance and bioaccumulation potential related to zinc, manganese and nickel...
April 3, 2018: Ecotoxicology and Environmental Safety
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