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https://www.readbyqxmd.com/read/28535270/intrinsically-photosensitive-retinal-ganglion-cell-function-sleep-efficiency-and-depression-in-advanced-age-related-macular-degeneration
#1
Michelle L Maynard, Andrew J Zele, Anthony S Kwan, Beatrix Feigl
Purpose: Melanopsin expressing intrinsically photosensitive retinal ganglion cells (ipRGC) input to multiple brain regions including those for pupil control, circadian rhythms, sleep and mood regulation. Here we measured ipRGC function and its relationship to sleep quality and depression in patients with advanced AMD. Methods: The melanopsin-mediated post-illumination pupil response (PIPR) was measured in 53 patients with advanced AMD (age 78.8 ± 8.8 years) and in 20 healthy controls (age 72...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28534244/proposal-of-a-simple-optical-coherence-tomography-based-scoring-system-for-progression-of-age-related-macular-degeneration
#2
Jianqin Lei, Siva Balasubramanian, Nizar Saleh Abdelfattah, Muneeswar G Nittala, SriniVas R Sadda
PURPOSE: To develop a simple, clinically practical, optical coherence tomography (OCT)-based scoring system for early age-related macular degeneration (AMD) to prognosticate risk for progression to late AMD. METHODS: We retrospectively reviewed OCT images (512 × 128 macular cube, Cirrus) from 138 patients diagnosed of early AMD in at least one eye and follow-up of at least 12 months. For patients with early AMD in both eyes, only the right eye was chosen as the study eye for longitudinal assessment...
May 22, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28532114/hypocrellin-b-and-nano-silver-loaded-polymeric-nanoparticles-enhanced-generation-of-singlet-oxygen-for-improved-photodynamic-therapy
#3
Subramanian Natesan, Venkateshwaran Krishnaswami, Chandrasekar Ponnusamy, Madi Madiyalakan, Thomas Woo, Rajaguru Palanisamy
A nanoparticulate photodynamic approach was employed with an objective to achieve enhanced production of singlet oxygen ((1)O2), for the management of posterior segment eye diseases like age related macular degeneration. The hypocrellin B (HB) loaded poly lactide-co-glycolide nanoparticle formulations were incorporated with nano silver (HBS-NPs). The optimized HBS-NPs contained 2.60±0.06mg/mL of HB and showed (i) 135.6 to 828.2nm size range, and (ii) negative zeta potential with a narrow polydispersity index...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531968/retention-of-metal-and-sulphate-ions-from-acidic-mining-water-by-anionic-nanofibrillated-cellulose
#4
Salla H Venäläinen, Helinä Hartikainen
We carried out an adsorption experiment to investigate the ability of anionic nanofibrillated cellulose (NFC) to retain metal and SO4(2-) ions from authentic highly acidic (pH3.2) mining water. Anionic NFC gels of different consistencies (1.1-%, 1.4-% and 1.8-% w/w) were allowed to react for 10min with mining water, after which NFC-induced changes in the metal and SO4(2-) concentrations of the mining water were determined. The sorption capacities of the NFC gels were calculated as the difference between the element concentrations in the untreated and NFC-treated mining water samples...
May 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28530793/resistive-switching-and-the-local-electric-field-in-the-bi0-85-xpr0-15rexfe0-97mn0-03o3-cufe2o4-re-sr-dy-bilayered-thin-films
#5
Zhongwei Yue, Guoqiang Tan, Huijun Ren, Ao Xia, Dan Shao, Meiyou Guo, Wei Yang, Zhengjun Chai
Bilayer Bi0.85-xPr0.15RExFe0.97Mn0.03O3/CuFe2O4 (BPRExFMO/CuFO, RE=Sr, Dy) thin films were prepared onto FTO/glass substrates by the chemical solution deposition method. The structure transition doesn't appear after ions doping, which is confirmed by XRD and its refined results. The samples remain the trigonal R3c: H structure of BFO phase and tetragonal I41/amd structure of CuFO phase. The asymmetric character of leakage current density curves and resistive switching effects have been explored. And the ions substitution impacts on the resistive switching effects may be due to the existence of the local fields...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28529701/recent-advances-in-the-management-of-dry-age-related-macular-degeneration-a-review
#6
REVIEW
Francesco Bandello, Riccardo Sacconi, Lea Querques, Eleonora Corbelli, Maria Vittoria Cicinelli, Giuseppe Querques
Age-related macular degeneration (AMD), the most important cause of vision loss in elderly people, is a degenerative disorder of the central retina with a multifactorial etiopathology. AMD is classified in dry AMD (d-AMD) or neovascular AMD depending on the presence of choroidal neovascularization. Currently, no therapy is approved for geographic atrophy, the late form of d-AMD, because no treatment can restore the damage of retinal pigment epithelium (RPE) or photoreceptors. For this reason, all treatment approaches in d-AMD are only likely to prevent and slow down the progression of existing atrophy...
2017: F1000Research
https://www.readbyqxmd.com/read/28526492/gene-therapy-for-the-long-term-treatment-of-wet-amd
#7
Elizabeth P Rakoczy
No abstract text is available yet for this article.
May 16, 2017: Lancet
https://www.readbyqxmd.com/read/28525563/omics-biomarkers-in-ophthalmology
#8
Susette Lauwen, Eiko K de Jong, Dirk J Lefeber, Anneke I den Hollander
"Omics" refers to high-throughput analyses of genes, proteins, or metabolites in a biological system, and is increasingly used for ophthalmic research. These system-based approaches can unravel disease-related processes and are valuable for biomarker discovery. Furthermore, potential therapeutic targets can be identified based on omics results, and targeted follow-up experiments can be designed to gain molecular understanding of the disease and to test new therapies. Here, we review the application of omics techniques in eye diseases, focusing on age-related macular degeneration (AMD), diabetic retinopathy (DR), retinal detachment (RD), myopia, glaucoma, Fuchs' corneal dystrophy (FCD), cataract, keratoconus, and dry eyes...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28524928/properties-of-visual-field-defects-around-the-monocular-preferred-retinal-locus-in-age-related-macular-degeneration
#9
Jonathan Denniss, Helen C Baggaley, Graham M Brown, Gary S Rubin, Andrew T Astle
Purpose: To compare microperimetric sensitivity around the monocular preferred retinal locus (mPRL) in age-related macular degeneration (AMD) to normative data, and to describe the characteristics of visual field defects around the mPRL in AMD. Methods: Participants with AMD (total n = 185) were either prospectively recruited (n = 135) or retrospectively reviewed from an existing database (n = 50). Participants underwent microperimetry using a test pattern (37 point, 5° radius) centered on their mPRL...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28524715/prevalence-of-age-related-macular-degeneration-in-slovakia-and-associated-risk-factors-a-mobile-clinic-based-cross-sectional-epidemiological-survey
#10
Vladimir Krasnik, Jana Stefanickova, Ivajlo Popov, Jela Valaskova, Sandeep Saxena, Peter Kruzliak
PURPOSE: Age-related macular degeneration (AMD) is one of the leading causes of blindness in the elderly population. Although there are prevalence studies for AMD in Europe, data are scarce for the Slovakian population. METHODS: This was a prospective, multicenter, non-interventional, mobile clinic-based cross-sectional study that assessed age-specific prevalence of AMD in the Slovakian population and risk factors associated with AMD. The type of AMD was graded based on the international age-related maculopathy grading system; optical coherence tomography (OCT) was used for the differential diagnosis...
May 19, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28524152/-vascular-endothelial-growth-factor-inhibitors-in-the-treatment-of-neovascular-age-related-macular-degeneration
#11
I N Dyakov, S K Zyryanov
Neovascular age-related macular degeneration (AMD) is the leading cause of vision loss in older patients. An important role in angiogenesis is played by regulatory mechanisms (an increase in the number of proliferating endothelial and stromal cells and morphological alterations in the vascular network) induced by factors from the vascular endothelial growth factor (VEGF) family. Since 2006, the key treatment of neovascular AMD includes agents that inhibit the activity of VEGF. This review covers the effectiveness and safety of the use of anti-VEGF agents in neovascular AMD patients...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28523069/crosstalk-between-aryl-hydrocarbon-receptor-and-glucocorticoid-receptor-in-human-retinal-pigment-epithelial-cells
#12
Hong Lan Jin, Yujin Choi, Kwang Won Jeong
The aryl hydrocarbon receptor (AHR) is known to mediate the cellular reaction involved in processing environmental contaminants and, ultimately, preventing accumulation of unfavorable extra lipids and proteins. Glucocorticoid receptor (GR) mediates the expression of genes associated with anti-inflammatory properties. Because AHR and GR are closely related in lipid metabolic dysregulation and inflammation, we speculate that AHR and GR may play a crucial role in AMD pathogenesis and focus on their crosstalk in human retinal pigment epithelial cells (ARPE-19)...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28522341/systemic-and-ocular-fluid-compounds-as-potential-biomarkers-in-age-related-macular-degeneration
#13
REVIEW
Eveline Kersten, Constantin C Paun, Rosa L Schellevis, Carel B Hoyng, Cécile Delcourt, Imre Lengyel, Tunde Peto, Marius Ueffing, Caroline C W Klaver, Sascha Dammeier, Anneke I den Hollander, Eiko K de Jong
Biomarkers can help unravel mechanisms of disease and identify new targets for therapy. They can also be useful in clinical practice for monitoring disease progression, evaluation of treatment efficacy and risk assessment in multifactorial diseases, such as age-related macular degeneration (AMD). AMD is a highly prevalent progressive retinal disorder for which multiple genetic and environmental risk factors have been described, but the exact etiology is not yet fully understood. Many compounds have been evaluated for their association with AMD...
May 15, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28514984/alternate-mediterranean-diet-score-is-positively-associated-with-skeletal-muscle-mass-index-in-middle-aged-adults
#14
Hui-Yuan Tian, Rui Qiu, Li-Peng Jing, Zhan-Yong Chen, Geng-Dong Chen, Yu-Ming Chen
Researches have suggested Mediterranean diet might lower the risk of chronic diseases, but data on skeletal muscle mass (SMM) are limited. This community-based cross-sectional study examined the association between the alternate Mediterranean diet score (aMDS) and SMM in 2230 females and 1059 males aged 40-75 years in Guangzhou, China. General information and habitual dietary information were assessed in face-to-face interviews conducted during 2008-2010 and 3 years later. The aMDS was calculated by summing the dichotomous points for the items of higher intakes of whole grain, vegetables, fruits, legumes, nuts, fish and ratio of MUFA:SFA, lower red meat and moderate ethanol consumption...
May 18, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28510780/design-and-testing-of-a-new-diatom-based-index-for-heavy-metal-pollution
#15
M R Fernández, G Martín, J Corzo, A de la Linde, E García, M López, M Sousa
The Tinto and Odiel river basins (SW Spain) are known worldwide for their unique water characteristics. Such uniqueness is a consequence of their flow through the Iberian Pyrite Belt (an area rich in metal sulphides) and the mining activities in the basins. A process of sulphide oxidation occurs in this region, which acidifies the water and increases the amount of heavy metals in it. As a result, the rivers suffer the so-called "acid mine drainage" (AMD). Traditional biotic diatom-based indexes (IPS, IBD, EPI-D, etc...
May 16, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28507131/involvement-of-a-gut-retina-axis-in-protection-against-dietary-glycemia-induced-age-related-macular-degeneration
#16
Sheldon Rowan, Shuhong Jiang, Tal Korem, Jedrzej Szymanski, Min-Lee Chang, Jason Szelog, Christa Cassalman, Kalavathi Dasuri, Christina McGuire, Ryoji Nagai, Xue-Liang Du, Michael Brownlee, Naila Rabbani, Paul J Thornalley, James D Baleja, Amy A Deik, Kerry A Pierce, Justin M Scott, Clary B Clish, Donald E Smith, Adina Weinberger, Tali Avnit-Sagi, Maya Lotan-Pompan, Eran Segal, Allen Taylor
Age-related macular degeneration (AMD) is the major cause of blindness in developed nations. AMD is characterized by retinal pigmented epithelial (RPE) cell dysfunction and loss of photoreceptor cells. Epidemiologic studies indicate important contributions of dietary patterns to the risk for AMD, but the mechanisms relating diet to disease remain unclear. Here we investigate the effect on AMD of isocaloric diets that differ only in the type of dietary carbohydrate in a wild-type aged-mouse model. The consumption of a high-glycemia (HG) diet resulted in many AMD features (AMDf), including RPE hypopigmentation and atrophy, lipofuscin accumulation, and photoreceptor degeneration, whereas consumption of the lower-glycemia (LG) diet did not...
May 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28506260/atypical-retinal-pigment-epithelial-defects-with-retained-photoreceptor-layers-a-so-far-disregarded-finding-in-age-related-macular-degeneration
#17
Helena Giannakaki-Zimmermann, Giuseppe Querques, Inger Christine Munch, Daraius Shroff, David Sarraf, Xuejing Chen, Eduardo Cunha-Souza, Sarah Mrejen, Vittorio Capuano, Murilo W Rodrigues, Charu Gupta, Andreas Ebneter, Martin S Zinkernagel, Marion R Munk
BACKGROUND: To report patients with age-related macular degeneration and atypical central retinal pigment epithelium (RPE) defects not attributable to geographic atrophy (GA) or RPE-tears with overlying preserved photoreceptor layers. METHODS: Multimodal imaging case-series evaluating the course of atypical RPE- defects in patients with AMD using Color fundus images, Optical coherence tomography (OCT), OCT-Angiography, fundus autofluorescence (FAF) and fluorescein-angiography (FA)...
May 15, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28506151/a-new-primary-mobility-tool-for-the-visually-impaired-a-white-cane-adaptive-mobility-device-hybrid
#18
John-Ross Rizzo, Kyle Conti, Teena Thomas, Todd E Hudson, Robert Wall Emerson, Dae Shik Kim
This article describes pilot testing of an adaptive mobility device-hybrid (AMD-H) combining properties of two primary mobility tools for people who are blind: the long cane and adaptive mobility devices (AMDs). The long cane is the primary mobility tool used by people who are blind and visually impaired for independent and safe mobility and AMDs are adaptive devices that are often lightweight frames approximately body width in lateral dimension that are simply pushed forward to clear the space in front of a person...
May 16, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28505617/ganglion-cell-complex-in-early-and-intermediate-age-related-macular-degeneration-evidence-by-sd-oct-manual-segmentation
#19
Pedro Camacho, Marco Dutra-Medeiros, Liliana Páris
PURPOSE: To evaluate ganglion cell layer (GCL) and ganglion cell complex (GCC) thickness manually by spectral-domain optical coherence tomography in subjects with early and intermediate age-related macular degeneration (AMD) in 12 locations on the horizontal meridian. METHODS: A total of 450 eyes (specifically, 246 eyes classified as having early/intermediate AMD plus 204 control eyes) were studied. Mann-Whitney U and Kruskal-Wallis tests were used to compare values between the healthy controls and the AMD group and also between the subgroups under study...
May 16, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28505013/disease-expression-in-nonexudative-age-related-macular-degeneration-varies-with-choroidal-thickness
#20
Richard F Spaide
PURPOSE: To investigate the relationship between subfoveal choroidal thickness and disease manifestation in a series of eyes with nonexudative age-related macular degeneration (AMD). METHODS: Retrospective study of eyes with nonexudative AMD. The extracellular deposits present, drusen and subretinal drusenoid deposits (SDD, pseudodrusen) along with a newly recognized form of drusen, pachydrusen, were graded and compared with choroidal thickness as determined by optical coherence tomography...
May 11, 2017: Retina
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