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https://www.readbyqxmd.com/read/29793068/prenatal-phthalate-exposure-birth-outcomes-and-dna-methylation-of-alu-and-line-1-repetitive-elements-a-pilot-study-in-china
#1
Li-Li Huang, Bin Zhou, Song-Hua Ai, Pan Yang, Ying-Jun Chen, Chong Liu, Yan-Ling Deng, Qing Lu, Xiao-Ping Miao, Wen-Qing Lu, Yi-Xin Wang, Qiang Zeng
BACKGROUND: Epigenetic mechanisms, such as altered DNA methylation, may participate in the relationship between prenatal phthalate exposure and adverse birth outcomes. OBJECTIVE: To explore the mediation effect of DNA methylation in the associations of phthalate exposure before delivery with birth outcomes in a Chinese cohort. METHODS: Eight phthalate metabolites in maternal urine before delivery and DNA methylation of Alu and long interspersed nucleotide elements (LINE-1) in cord blood were determined among 106 mother-infant pairs...
May 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29792935/lp533401-restores-bone-health-in-5-6-nephrectomized-rats-by-a-decrease-of-gut-derived-serotonin-and-regulation-of-serum-phosphate-through-the-inhibition-of-phosphate-co-transporters-expression-in-the-kidneys
#2
Dariusz Pawlak, Beata Znorko, Bartlomiej Kalaska, Tomasz Domaniewski, Radosław Zawadzki, Paweł Lipowicz, Michał Doroszko, Urszula Łebkowska, Piotr Grabowski, Krystyna Pawlak
LP533401 is an orally bioavailable small molecule that inhibits tryptophan hydroxylase-1, an enzyme responsible for the synthesis of gut-derived serotonin (GDS). Recently, we showed that increased GDS in rats with chronic kidney disease (CKD) affected bone strength and metabolism. We tested the hypothesis that treatment with LP533401 could reverse CKD-induced bone loss in uremia. Sixteen weeks after 5/6 nephrectomy, rats were randomized into untreated (CKD), treated with vehicle (VEH) and LP533401 at a dose of 30 or 100 mg/kg daily for 8 weeks...
May 21, 2018: Bone
https://www.readbyqxmd.com/read/29792574/evaluation-of-a-mobile-application-for-pelvic-floor-exercises
#3
Michelle N Han, Tamara Grisales, Aparna Sridhar
BACKGROUND: Pelvic floor exercises are effective in improving muscle strength and urinary incontinence symptoms. Increasingly popular mobile applications can be effective in teaching patients these exercises. INTRODUCTION: A mobile application, Bwom© , aims to educate women about pelvic floor exercises with individually tailored plans relevant to the user's risk factors. The objective of this study is to assess the understandability and actionability of Bwom. MATERIALS AND METHODS: This is a cross-sectional survey of patients and providers at an academic medical center...
May 24, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29792542/defining-bladder-health-in-women-and-girls-implications-for-research-clinical-practice-and-public-health-promotion
#4
Emily S Lukacz, Tamara G Bavendam, Amanda Berry, Cynthia S Fok, Sheila Gahagan, Patricia S Goode, Cecilia T Hardacker, Jeni Hebert-Beirne, Cora E Lewis, Jessica Lewis, Lisa Kane Low, Jerry L Lowder, Mary H Palmer, Ariana L Smith, Sonya S Brady
BACKGROUND: Bladder health in women and girls is poorly understood, in part, due to absence of a definition for clinical or research purposes. This article describes the process used by a National Institutes of Health funded transdisciplinary research team (The Prevention of Lower Urinary Tract Symptoms [PLUS] Consortium) to develop a definition of bladder health. METHODS: The PLUS Consortium identified currently accepted lower urinary tract symptoms (LUTS) and outlined elements of storage and emptying functions of the bladder...
May 24, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29792359/adverse-effect-analysis-of-high-intensity-focused-ultrasound-in-the-treatment-of-benign-uterine-diseases
#5
Yunchang Liu, Wendy Wenyi Zhang, Min He, Chunmei Gong, Bin Xie, Xiangxia Wen, Dandan Li, Lian Zhang
OBJECTIVE: To retrospectively analyze the adverse effects of high-intensity focused ultrasound (HIFU) in management of benign uterine diseases. MATERIALS AND METHODS: From 2011 to 2017, 27,053 patients with benign uterine diseases were treated with HIFU in 19 centers in China. Among them, 17,402 patients had uterine fibroids, 8434 had adenomyosis, 876 had caesarean scar pregnancies, and 341 had placenta accreta. RESULTS: The median age, height, weight, BMI of the patients was 42 years, 158 mm, 56 kg, 22...
May 24, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29792287/safety-tolerability-pharmacokinetics-and-pharmacodynamics-of-glpg1690-a-novel-autotaxin-inhibitor-to-treat-idiopathic-pulmonary-fibrosis-flora-a-phase-2a-randomised-placebo-controlled-trial
#6
Toby M Maher, Ellen M van der Aar, Olivier Van de Steen, Lisa Allamassey, Julie Desrivot, Sonia Dupont, Liesbeth Fagard, Paul Ford, Ann Fieuw, Wim Wuyts
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) causes irreversible loss of lung function. People with IPF have increased concentrations of autotaxin in lung tissue and lysophosphatidic acid (LPA) in bronchoalveolar lavage fluid and exhaled condensate. GLPG1690 (Galapagos, Mechelen, Belgium) is a novel, potent, selective autotaxin inhibitor with good oral exposure. We explored the effects of GLPG1690 in patients with IPF. METHODS: This was a randomised, double-blind, placebo-controlled phase 2a study done in 17 centres in Italy, Ukraine and the UK...
May 18, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29792180/screening-for-congenital-fetal-anomalies-in-low-risk-pregnancy-the-kenyatta-national-hospital-experience
#7
Callen Kwamboka Onyambu, Norah Mukiri Tharamba
BACKGROUND: Congenital malformations contribute significantly to the disease burden among children globally. A study conducted in Kenya on understanding the burden of surgical congenital anomalies, highlights the need for Kenyan health systems to go beyond the medical dimensions of illness. This could be achieved by linking knowledge of the severe congenital anomalies (CAs) and their impact of varying disability to the delivery of local health services and public health program planning...
May 23, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29792170/liddle-s-like-syndrome-associated-with-nephrotic-syndrome-secondary-to-membranous-nephropathy-the-first-case-report
#8
Eriko Yamaguchi, Kazuhiro Yoshikawa, Izaya Nakaya, Karen Kato, Yoshikazu Miyasato, Terumasa Nakagawa, Yutaka Kakizoe, Masashi Mukoyama, Jun Soma
BACKGROUND: Liddle's syndrome is a rare monogenic form of hypertension caused by truncating or missense mutations in the C termini of the epithelial sodium channel (ENaC) β or γ subunits. Patients with this syndrome present with early onset of hypertension, hypokalemia, metabolic alkalosis, hyporeninemia and hypoaldosteronism, and a potassium-sparing diuretics (triamterene or amiloride) can drastically improves the disease condition. Although elderly patients having these characteristics were considered to have Liddle's syndrome or Liddle's-like syndrome, no previous report has indicated that Liddle's-like syndrome could be caused by nephrotic syndrome of primary glomerular disease, which is characterized by urinary excretion of > 3 g of protein/day plus edema and hypoalbuminemia, or has explained how the activity function of ENaC could be affected in the setting of high proteinuria...
May 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29792114/innovating-urinary-catheter-design-an-introduction-to-the-engineering-challenge
#9
Cathy Murphy
Every day, people around the world rely on intermittent and indwelling urinary catheters to manage bladder dysfunction, but the potential or actual harm caused by these devices is well-recognised. Current catheter designs can cause urinary tract infection and septicaemia, bladder and urethral trauma and indwelling devices frequently become blocked. Furthermore, the devices can severely disrupt users' lives, limiting their daily activities and can be costly to manage for healthcare providers. Despite this, little significant design innovation has taken place in the last 80 years...
May 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29791981/inguinoscrotal-hernia-containing-the-urinary-bladder-successfully-repaired-using-laparoscopic-transabdominal-preperitoneal-repair-technique-a-case-report
#10
Tatsuya Tazaki, Masaru Sasaki, Mohei Kohyama, Yoichi Sugiyama, Shinnosuke Uegami, Ryuta Shintakuya, Yuji Imamura, Atsushi Nakamitsu
We report herein a patient with an inguinoscrotal hernia containing the urinary bladder. The hernia was safely repaired using the laparoscopic transabdominal preperitoneal repair technique. A 76-year-old man was admitted to our hospital with abdominal pain, vomiting, and diarrhea. His scrotum was swollen to fist size. Abdominal CT showed herniation of the sigmoid colon and the bladder into the right inguinal region, and his abdominal pain was attributed to incarceration of the sigmoid colon; this was manually reduced...
May 23, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29791760/neopterin-7-8-dihydroneopterin-is-elevated-in-duchenne-muscular-dystrophy-patients-and-protects-mdx-skeletal-muscle-function
#11
Angus Lindsay, Alexandra Schmiechen, Christopher M Chamberlain, James M Ervasti, Dawn A Lowe
Macrophage infiltration is a hallmark of dystrophin-deficient muscle. We tested the hypothesis that Duchenne muscular dystrophy (DMD) patients would have elevated levels of the macrophage synthesized pterins, neopterin and 7,8-dihydroneopterin compared to unaffected age-matched controls. Urinary neopterin/creatinine and 7,8-dihydroneopterin/creatinine were elevated in DMD patients and 7,8-dihydroneopterin/creatinine was associated with patient age and ambulation. 7,8-dihydroneopterin correction with specific gravity was also elevated in DMD patients...
May 23, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29791707/evaluation-of-the-safety-and-efficacy-of-a-novel-radiofrequency-device-for-vaginal-treatment
#12
Jeffrey C Caruth
INTRODUCTION: Vaginal laxity and atrophy are caused mainly by aging and vaginal childbirth, which lead to a loss of strength and flexibility within the vaginal wall. As a result, women may experience vaginal, pelvic, sexual and urinary symptoms that significantly affect their quality of life. OBJECTIVE: The aim of this study was to evaluate the safety and efficacy of a novel radiofrequency (RF) device for internal and external vaginal treatment. METHODS: Thirty women who had been diagnosed with symptoms of vaginal laxity and pelvic relaxation received a single treatment that consisted of continuous RF in the internal genitalia and continuous RF followed by fractional RF in the external vulva...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791696/monocenter-experience-with-532-nm-laser-photoselective-vaporization-of-the-prostate-by-greenlight-xps%C3%A2-laser-is-it-really-an-endourological-joker-card
#13
Jamil Ghahhari, Carlo D'Orta, Ambra Rizzoli, Michele Marchioni, Giulia I Primicer, Piergustavo De Francesco, Angelo Civitella, Mario Di Lecce, Pietro Castellan, Roberto Castellucci, Fabio Neri, Fabiola Raffaella Tamburro, Luca Cindolo, Luigi Schips
INTRODUCTION: In our study, we reported on our monocenter experience with GreenLight (GL) Xcelerated Performance System (XPS)™ /MoXy™ laser fiber (American Medical Systems Inc., Minnetonka, Minnesota), examining its efficacy, safety, and its ability to effectively treat lower urinary tract symptoms (LUTS) in benign prostate obstruction (BPO). We also explored and compared the three different endoscopic approaches used for GL treatment of benign prostatic hyperplasia (BPH), standard photovaporization (PVP), anatomical PVP, and GreenLight XPS™ enucleation of the prostate...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791640/factors-associated-to-the-dependence-of-older-adults-with-diabetes-mellitus-type-2
#14
Adélia Dayane Guimarães Fonseca, Carla Silvana de Oliveira E Silva, Dulce Aparecida Barbosa, Elaine Cristina Santos Alves, Lucinéia de Pinho, Maria Fernanda Santos Figueiredo Brito, Mônica Antar Gamba
OBJECTIVE: to identify factors associated to the dependence of older adults with Diabetes Mellitus, Type 2 Method: analytical and epidemiological study with 99 older adults. The Brazilian Multidimensional Functional Assessment Questionnaire and a questionnaire composed by socio-demographic and clinical variables were used. The independent variables were described and compared to the level of dependence obtained by the chi-square test or the Fisher test, the strength of association was estimated by Odds Ratio and multiple regression...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791502/anthropometry-based-24-h-urinary-creatinine-excretion-reference-for-chinese-children
#15
Wei Wang, Cong Du, Laixiang Lin, Wen Chen, Long Tan, Jun Shen, Elizabeth N Pearce, Yixin Zhang, Min Gao, Jianchao Bian, Xiaoming Wang, Wanqi Zhang
To establish 24-h urinary creatinine excretion reference ranges based on anthropometry in healthy Chinese children, a cross-sectional survey was conducted using twice-sampled 24-h urine and anthropometric variables. Age- and sex-specific 24-h creatinine excretion reference ranges (crude and related to individual anthropometric variables) were derived. During October 2013 and May 2014, urine samples were collected. Anthropometric variables were measured in the first survey. Data of 710 children (377 boys and 333 girls) aged 8-13 years who completed the study were analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29791319/malignancy-in-a-retrospective-cohort-of-17-patients-with-dermatomyositis-or-polymyositis-in-southern-tunisia
#16
Khadija Sellami, Madiha Mseddi, Mouna Snoussi, Hela Gharbi, Faten Frikha, Rayda Ben Salah, Moez Jallouli, Sameh Marzouk, Abderrahmen Masmoudi, Zouhir Bahloul, Hamida Turki
INTRODUCTION: The prognosis of dermatomyositis (DM)/polymyositis (PM) in adults is partly related to their association with neoplasia. The aim of our study was to report the epidemiologic, clinical, paraclinical, therapeutic and evolutionary aspects of DM associated with malignancy in patients from Sfax, south eastern of Tunisia. METHODS: A retrospective cohort study of patients with DM or PM admitted in Dermatology and Internal Medicine Departments of Hedi Chaker University Hospital of Sfax between 1996 and 2015...
May 21, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29791309/retraction-of-external-quality-assessment-programs-in-the-us-with-an-emphasis-on-urinary-sediment-testing-the-college-of-american-pathologists-experience
#17
Eric F Glassy, David J Blomberg
No abstract text is available yet for this article.
May 23, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29791217/prevention-of-dehydration-in-hospital-patients
#18
Rebecca Shells, Nicola Morrell-Scott
Dehydration is widely linked to increased risk of mortality in patients who are acutely unwell, and it also increases the risk of further illness. Despite being recognised nationwide as a cause for concern, 45% of hospital patients will become dehydrated upon admission, suggesting that more needs to be done to prevent dehydration. The use of bedside water devices allows patients to drink freely without assistance. Access to these can reduce a patient's length of stay in hospital and minimise the risk of developing a urinary tract infection...
May 24, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29791205/physiologic-hyperinsulinemia-caused-by-acute-hyperglycemia-minimizes-renal-sodium-loss-by-direct-action-on-the-kidney
#19
Debra L Irsik, Michael W Brands
This study used acute, renal-artery insulin infusion in conscious rats to test the hypothesis that hyperinsulinemia attenuates glucose-induced natriuresis by a direct renal mechanism. We reported previously that hyperinsulinemia was required to prevent ad libitum eating or an acute glucose bolus from causing excessive renal sodium loss. Rats were instrumented with renal artery, aortic, and femoral vein catheters and DSI blood pressure telemeters and were housed in metabolic cages. Insulin was clamped chronically at normal levels in two groups (irV and irI) by administering streptozotocin and then infusing insulin iv...
May 23, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29791078/molecular-subtype-classification-of-urothelial-carcinoma-in-lynch-syndrome
#20
Christina Therkildsen, Pontus Eriksson, Mattias Höglund, Mats Jönsson, Gottfrid Sjödahl, Mef Nilbert, Fredrik Liedberg
Lynch syndrome confers an increased risk for urothelial carcinoma (UC). Molecular subtypes may be relevant to prognosis and therapeutic possibilities, but have to date not been defined in Lynch syndrome-associated urothelial cancer. We aimed to provide a molecular description of Lynch syndrome-associated UC. Thus, Lynch syndrome-associated UC of the upper urinary tract and the urinary bladder were identified in the Danish hereditary non-polyposis colorectal cancer (HNPCC) register and were transcriptionally and immunohistochemically profiled and further related to data from 307 sporadic urothelial carcinomas...
May 23, 2018: Molecular Oncology
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