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https://www.readbyqxmd.com/read/29786850/plasticizers-and-bpa-residues-in-tunisian-and-italian-culinary-herbs-and-spices
#1
Giuseppa Di Bella, Hedi Ben Mansour, Asma Ben Tekaya, Asma Beltifa, Angela Giorgia Potortì, Emanuele Saiya, Giovanni Bartolomeo, Giacomo Dugo, Vincenzo Lo Turco
In the present study, 18 plasticizers and residues in 10 different Tunisian and Italian culinary herbs and spices (black pepper, mint, caraway, coriander, oregano, rosemary, thyme, fennel, verbena, and laurel) were determined by GC/MS. Di-methylphthalate, di-(2-methylpropyl)adipate, di-n-butyladipate, di-propylphthalate, benzylbenzoate, di-phenylphthalate, and bisphenol A were lower than their LOQ in all 118 samples. Among the Tunisian samples, di-(2-ethylhexyl)phthalate was found in all types of samples and di-butylphthalate in 50% of types; all other phthalates were rarely dectected...
May 22, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29781116/trends-and-current-challenges-of-breast-cancer-in-tunisia-a-retrospective-study-of-1262-cases-with-survival-analysis
#2
Imtinene Belaid, Leila Ben Fatma, Faten Ezzairi, Makrem Hochlaf, Imene Chabchoub, Olfa Gharbi, Salma Gahbiche, Moncef Mokni, Abdelfattah Zakhama, Mohamed Bibi, Hedi Khairi, Slim Ben Ahmed
No abstract text is available yet for this article.
May 20, 2018: Breast Journal
https://www.readbyqxmd.com/read/29772690/peritoneal-carcinomatosis-targeting-with-tumor-homing-peptides
#3
REVIEW
Lorena Simón-Gracia, Hedi Hunt, Tambet Teesalu
Over recent decades multiple therapeutic approaches have been explored for improved management of peritoneally disseminated malignancies-a grim condition known as peritoneal carcinomatosis (PC). Intraperitoneal (IP) administration can be used to achieve elevated local concentration and extended half-life of the drugs in the peritoneal cavity to improve their anticancer efficacy. However, IP-administered chemotherapeutics have a short residence time in the IP space, and are not tumor selective. An increasing body of work suggests that functionalization of drugs and nanoparticles with targeting peptides increases their peritoneal retention and provides a robust and specific tumor binding and penetration that translates into improved therapeutic response...
May 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29771789/raltegravir-1200-mg-once-daily-vs-400-mg-twice-daily-with-emtricitabine-and-tenofovir-disoproxil-fumarate-for-previously-untreated-hiv-1-infection-week-96-results-from-oncemrk-a-randomized-double-blind-non-inferiority-trial
#4
Pedro Cahn, Paul E Sax, Kathleen Squires, Jean-Michel Molina, Winai Ratanasuwan, Mohammed Rassool, Mark Bloch, Xia Xu, Yan Zhou, Brenda Homony, Deborah Hepler, Hedy Teppler, George J Hanna, Bach-Yen Nguyen, Wayne Greaves
BACKGROUND: Raltegravir 1200mg (2x600mg tablets) once daily (QD) demonstrated non-inferior efficacy and similar safety to raltegravir 400mg BID at Week 48 of the ONCEMRK trial. Here we report the Week 96 results from this study. METHODS: ONCEMRK is a phase 3, multicenter, double-blind, non-inferiority trial comparing raltegravir 1200mg QD to raltegravir 400mg BID in treatment-naïve HIV-1-infected adults. Participants were assigned (2:1) to raltegravir 2x600mg QD or 400mg BID, both with emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) for 96 weeks...
May 3, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29735420/-post-streptococcal-glomerulonephritis-in-the-south-of-tunisia-a-12-year-retrospective-review
#5
Bayen Maalej, Mona Ben Amor, Manel Jallouli, Manel Weli, Mohamed Charfi, Yassine Abdelkefi, Olfa Chakroun, Khaoula Kamoun, Jamil Hachicha, Noureddine Rekik, Taher Gargah, Lamia Gargouri, Abdelmajid Mahfoudh
AIM: Post-streptococcal glomerulonephritis (PSGN) is a frequent cause of acute nephritis in children. This study aimed to describe the epidemiology, clinical characteristics and outcomes of PSGN and look for predictor's factors of severity. METHODS: A 12-year retrospective review of case notes and laboratory data was conducted at a department of pediatrics, pediatric emergency and intensive care, Hedi Chaker Hospital. RESULTS: One hundred seventy eight children were treated for PSGN with a mean age of 7...
May 4, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29710284/association-of-survival-with-adherence-to-the-american-cancer-society-nutrition-and-physical-activity-guidelines-for-cancer-survivors-after-colon-cancer-diagnosis-the-calgb-89803-alliance-trial
#6
Erin L Van Blarigan, Charles S Fuchs, Donna Niedzwiecki, Sui Zhang, Leonard B Saltz, Robert J Mayer, Rex B Mowat, Renaud Whittom, Alexander Hantel, Al Benson, Daniel Atienza, Michael Messino, Hedy Kindler, Alan Venook, Shuji Ogino, Edward L Giovannucci, Kimmie Ng, Jeffrey A Meyerhardt
Importance: The American Cancer Society Nutrition and Physical Activity Guidelines for Cancer Survivors (ACS guidelines) include maintaining (1) a healthy body weight; (2) physical activity; and (3) a diet that includes vegetables, fruits, and whole grains. It is not known whether patients with colon cancer who follow these guidelines have improved survival. Objective: To examine whether a lifestyle consistent with the ACS guidelines is associated with improved survival rates after colon cancer...
April 12, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29708239/gold-doped-silver-nanoclusters-with-enhanced-photophysical-properties
#7
Dinesh Mishra, Vladislav Lobodin, Chengqi Zhang, Fadi Aldeek, Eric Lochner, Hedi Mattoussi
We detail the characterization of atomically precise, luminescent silver and gold bimetallic nanoclusters (Ag and AgAuNCs) grown in the presence of bidentate lipoic acid (LA, the oxidized form) and dihydrolipoic acid (DHLA, the reduced form) ligands. We found that while doping AuNCs with Ag or Cu precursors using up to a 50% molar fraction (during growth) did not lead to any photoluminescence enhancement, doping of AgNCs with Au resulted in a six-fold enhancement of the PL emission compared to undoped AgNCs...
April 30, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29705133/determination-of-the-binding-properties-of-p-cresyl-glucuronide-to-human-serum-albumin
#8
Dan Yi, Elisa Bernardes Monteiro, Stéphane Chambert, Hédi A Soula, Julio B Daleprane, Christophe O Soulage
p-Cresyl glucuronide (p-CG) is a by-product of tyrosine metabolism that accumulates in patients with end-stage renal disease. p-CG binding to human serum albumin in physiological conditions (37°C, pH 7.40) was studied by ultrafiltration (MWCO 10 kDa) and data were analyzed assuming one binding site. The estimated value of the association constant was 2.77×103  M-1 and a maximal stoichiometry of 3.80 mol per mole. At a concentration relevant for end-stage renal patients, p-CG was 23% bound to albumin...
April 26, 2018: Biochimie
https://www.readbyqxmd.com/read/29696561/comparing-quality-of-care-in-veterans-affairs-and-non-veterans-affairs-settings
#9
Rebecca Anhang Price, Elizabeth M Sloss, Matthew Cefalu, Carrie M Farmer, Peter S Hussey
BACKGROUND: Congress, veterans' groups, and the press have expressed concerns that access to care and quality of care in Department of Veterans Affairs (VA) settings are inferior to access and quality in non-VA settings. OBJECTIVE: To assess quality of outpatient and inpatient care in VA at the national level and facility level and to compare performance between VA and non-VA settings using recent performance measure data. MAIN MEASURES: We assessed Patient Safety Indicators (PSIs), 30-day risk-standardized mortality and readmission measures, and ORYX measures for inpatient safety and effectiveness; Healthcare Effectiveness Data and Information Set (HEDIS®) measures for outpatient effectiveness; and Consumer Assessment of Healthcare Providers and Systems Hospital Survey (HCAHPS) and Survey of Healthcare Experiences of Patients (SHEP) survey measures for inpatient patient-centeredness...
April 25, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29664657/enterobius-vermicularis-a-cause-of-abdominal-pain-mimicking-acute-appendicitis-in-children-a-retrospective-cohort-study
#10
Mohamed Zouari, Hamid Louati, Imen Abid, Fatma Trabelsi, Mahdi Ben Dhaou, Mohamed Jallouli, Riadh Mhiri
BACKGROUND: Enterobius vermicularis (EV) is the most common helminthic infection in the world. This small parasite is predominant in the pediatric population. The presence of EV in the appendix can cause or mimick appendicitis. The aim of our study was to compare patients with EV infection and those without EV infection, and to identify predictive factors that may help the diagnosis of EV infection in patients presenting with right iliac fossa pain and avoid negative appendectomy. METHODS: A retrospective analysis of all the appendices removed between January 2012 and December 2016 was conducted at the department of pediatric surgery, Hedi Chaker Hospital, Sfax, Tunisia...
February 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29653350/relevance-of-treated-cocaine-users-retrospective-memory-of-first-cocaine-use
#11
Emily Karsinti, Kristel Piani, El Hedi Zerdazi, Uwe Maskos, Philippe Faure, Lucia Romo, Frank Bellivier, Georges Brousse, Jean Pierre Lépine, Vanessa Bloch, Florence Vorspan
Little is known regarding between-subject variability in the subjective effects of first cocaine use. This study retrospectively assesses the subjective effects of first cocaine use in 160 current treatment-seeking cocaine use disorder patients. Subjective effects of first cocaine use were evaluated with an ad-hoc questionnaire used for cannabis effects. A principal component analysis (PCA) was performed, with resulting factors correlated with clinical variables (α = 0.05). Four factors emerged in the PCA, namely Anxiety (accounting for 21...
March 29, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29602966/the-role-of-perceived-air-pollution-and-health-risk-perception-in-health-symptoms-and-disease-a-population-based-study-combined-with-modelled-levels-of-pm-10
#12
Kati Orru, Steven Nordin, Hedi Harzia, Hans Orru
PURPOSE: Adverse health impact of air pollution on health may not only be associated with the level of exposure, but rather mediated by perception of the pollution and by top-down processing (e.g. beliefs of the exposure being hazardous), especially in areas with relatively low levels of pollutants. The aim of this study was to test a model that describes interrelations between air pollution (particles < 10 [Formula: see text]m, PM10 ), perceived pollution, health risk perception, health symptoms and diseases...
March 31, 2018: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29595326/a-real-world-analysis-of-glycemic-control-among-patients-with-type-2-diabetes-treated-with-canagliflozin-versus-dapagliflozin
#13
Lawrence Blonde, Charmi Patel, Brahim Bookhart, Michael Pfeifer, Yen-Wen Chen, Bingcao Wu
OBJECTIVE: This US retrospective cohort study compared the real-world effectiveness of canagliflozin 300 mg versus dapagliflozin 10 mg on HbA1c reduction in patients with type 2 diabetes mellitus (T2DM). METHODS: Patients initiated on canagliflozin 300 mg or dapagliflozin 10 mg were identified from de-identified claims data in the Optum Clinformatics® database (1/1/2014-9/30/2016). Propensity score matching was used to create balanced cohorts. The primary outcome was proportion of patients with HbA1c <8...
March 29, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29578853/michigan-pharmacists-transforming-care-and-quality-developing-a-statewide-collaborative-of-physician-organizations-and-pharmacists-to-improve-quality-of-care-and-reduce-costs
#14
Hae Mi Choe, Alexandra Tungol Lin, Kathleen Kobernik, Marc Cohen, Laurie Wesolowicz, Nabeel Qureshi, Tom Leyden, David A Share, Rozanne Darland, David A Spahlinger
BACKGROUND: Inappropriate drug use, increasing complexity of drug regimens, continued pressure to control costs, and focus on shared accountability for clinical measures drive the need to leverage the medication expertise of pharmacists in direct patient care. A statewide strategy based on the collaboration of pharmacists and physicians regarding patient care was developed to improve disease state management and medication-related outcomes. PROGRAM DESCRIPTION: Blue Cross Blue Shield of Michigan (BCBSM) partnered with Michigan Medicine to develop and implement a statewide provider-payer program called Michigan Pharmacists Transforming Care and Quality (MPTCQ), which integrates pharmacists within physician practices throughout the state of Michigan...
April 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29557802/patient-and-system-characteristics-associated-with-performance-on-the-hedis-measures-of-alcohol-and-other-drug-treatment-initiation-and-engagement
#15
Bobbi Jo H Yarborough, Felicia W Chi, Carla A Green, Agatha Hinman, Jennifer Mertens, Arne Beck, Michael Horberg, Constance Weisner, Cynthia I Campbell
OBJECTIVES: Understand patient and system characteristics associated with performance on the Healthcare Effectiveness Data and Information Set (HEDIS) Alcohol and Other Drug (AOD) Initiation and Engagement of Treatment (IET) measures. METHODS: This mixed-methods study linked patient and health system data from four Kaiser Permanente regions to HEDIS performance measure data for 44,320 commercially or Medicare-insured adults with HEDIS-eligible AOD diagnoses in 2012...
March 19, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29534880/the-impact-of-changes-in-radiographic-sarcopenia-on-overall-survival-in-older-adults-undergoing-different-treatment-pathways-for-pancreatic-cancer
#16
Andrew J Benjamin, Mary M Buschmann, Shuang Qin Zhang, Kristen Wroblewski, Hedy L Kindler, Kevin K Roggin, William Dale
OBJECTIVE: Sarcopenia is associated with poor outcomes in patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC). However, few studies have assessed changes in sarcopenia during multimodality therapy or its effect on overall survival (OS). METHODS: Computed tomography (CT) total psoas area index (TPAI) and weighted average Hounsfield units (HU) were measured at each treatment interval in patients with resectable PDAC. Four cohorts were compared: 1...
March 10, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29527028/adverse-reactions-due-to-the-bacillus-calmette-guerin-vaccine-twenty-tunisian-cases
#17
Khadija Sellami, Meriem Amouri, Sana Kmiha, Emna Bahloul, Hajer Aloulou, Lamia Sfaihi, R Guirat, Madiha Mseddi, T Kamoun, Mongia Hachicha, Hamida Turki
Background: Bacillus Calmette-Guérin (BCG) vaccine is a widely used vaccine. Management of local BCG complications differs between clinicians, and the optimal approach remains unclear. Aims: We aim to describe the epidemiological, clinical and therapeutic aspects of the BCG vaccine side effects in Sfax. Patients and Methods: This was a retrospective study of all the cases of BCG vaccine adverse reactions recorded in the Dermatology and Paediatrics Departments of Hedi Chaker University Hospital of Sfax over a period of 10 years (2005-2015)...
January 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29517955/treatment-of-malignant-pleural-mesothelioma-american-society-of-clinical-oncology-clinical-practice-guideline-summary
#18
Hedy L Kindler, Nofisat Ismaila, Raffit Hassan
No abstract text is available yet for this article.
April 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29499811/meeting-quality-measures-for-adolescent-preventive-care-assessing-the-perspectives-of-key-stakeholders
#19
Sarika Rane Parasuraman, Sarah Lindstrom Johnson, Dawn Magnusson, Tracy King
BACKGROUND: Health plans are increasingly implementing quality improvement strategies aimed at meeting adolescent clinical quality measures, yet clinics often struggle to meet these measures. This qualitative study was conducted to explore how efforts to meet the National Committee for Quality Assurance (NCQA) Healthcare Effectiveness Data and Information Set (HEDIS) performance measure for adolescent well-care visits were perceived by a multidisciplinary group of stakeholders. METHODS: The research team conducted 26 in-depth, semistructured interviews with participants from three stakeholder groups: clinic staff with direct patient contact, health care institutional leaders, and representatives of a payer organization...
March 2018: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/29492930/autoimmune-gastritis-assessment-of-olga-and-olgim-staging-systems
#20
Sana Ben Slama, Dorra Ben Ghachem, Amen Dhaoui, Sarra Ben Rejeb, Mohamed Taieb Jomni, Mohamed Hédi Dougui, Khadija Bellil
BACKGROUND: Autoimmune gastritis present a risk of cancer related to atrophy and intestinal metaplasia. Two recent classifications OLGA (Operative Link on Gastritis Assessment) and OLGIM (Operative Link on Gastritic Intestinal Metaplasia assessment) have been proposed to reveal the high progressive risk forms (stages III and IV). AIM: To evaluate the OLGA and OLGIM staging systems in chronic autoimmune gastritis. METHODS: A descriptive single institution study of 30 cases of autoimmune gastritis...
April 2017: La Tunisie Médicale
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