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Wickii T Vigneswaran, Diana Y Kircheva, Vijayalakshimi Ananthanarayanan, Sydeaka Watson, Qudsia Arif, Amy Durkin Celauro, Hedy L Kindler, Aliya N Husain
BACKGROUND: Macroscopic complete surgical resection with adjuvant chemotherapy can provide a survival advantage in patients with malignant pleural mesothelioma (MPM). Patients with nonepithelioid histology are largely excluded from such radical operations even though they might benefit. The degree of epithelioid differentiation varies in biphasic histology. We report the outcomes of pleurectomy and decortication and the effect of epithelioid differentiation on overall survival of patients with MPM...
October 17, 2016: Annals of Thoracic Surgery
Sebastiaan J M Vreeswijk, Hedi L Claahsen, Wilfred A Borstlap, Mark P Hendriks
No abstract text is available yet for this article.
November 2016: European Journal of Anaesthesiology
Ferdaous Maâtouk, Mouna Maâtouk, Karima Bekir, Houcine Barhoumi, Abderrazak Maaref, Hedi Ben Mansour
In this work we report the development of an electrochemical DNA biosensor with high sensitivity for mercury ion detection. A new matrix based on gold nanoparticles (AuNPs)-glutathione (GSH)/cysteine was investigated. The interaction between DNA oligonucleotides and Hg(2+) ions followed by the formation of Thymine-Hg(2+)-Thymine (T-Hg(2+)-T) structures was quantified using different electrochemical methods. It has been shown that the electrochemical impedance spectroscopy (EIS) measurements and the differential pulse voltammetry (DPV) confirmed the specific interaction between the oligonucleotide receptor layer and the Hg(2+) ions...
October 2016: Journal of Water and Health
Christopher Piorkowski, Ole-A Breithardt, Hedi Razavi, Yelena Nabutovsky, Stuart P Rosenberg, Craig D Markovitz, Arash Arya, Sascha Rolf, Silke John, Jedrzej Kosiuk, Eric Olson, Charlotte Eitel, Yan Huo, Michael Döring, Sergio Richter, Kyungmoo Ryu, Thomas Gaspar, Frits W Prinzen, Gerhard Hindricks, Philipp Sommer
AIMS: In times of evolving cardiac resynchronization therapy, intra-procedural characterization of left ventricular (LV) mechanical activation patterns is desired but technically challenging with currently available technologies. In patients with normal systolic function, we evaluated the feasibility of characterizing LV wall motion using a novel sensor-based, real-time tracking technology. METHODS AND RESULTS: Ten patients underwent simultaneous motion and electrical mapping of the LV endocardium during sinus rhythm using electroanatomical mapping and navigational systems (EnSite™ NavX™ and MediGuide™, SJM)...
October 12, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Alberto Striolo, Jongwook Kim, Catherine Murphy, Luis Liz-Marzán, Joerg Lahann, Javier Reguera, Yu Zhou, Mathias Brust, Antoine Thill, Leonardo Scarabelli, Tobias A F König, Martin Buzza, Christian Kuttner, Estefania Gonzalez Solveyra, Heiko Wolf, Jan Vermant, Matthias Pauly, Andrew Harvie, Lucia Pasquato, Antonio Stocco, Hedi Mattoussi, Eugenia Kumacheva, Kelley Heatley, Christoph Hanske, Roland Faller, David French, Andrei Honciuc, Bernard Binks, Francois Sicard
No abstract text is available yet for this article.
October 6, 2016: Faraday Discussions
Andrea Castelli, Alberto Striolo, Anna Roig, Catherine Murphy, Javier Reguera, Luis Liz-Marzán, Axel Mueller, Kevin Critchley, Yu Zhou, Mathias Brust, Antoine Thill, Leonardo Scarabelli, Luciano Tadiello, Tobias A F König, Beate Reiser, M Arturo López-Quintela, Martin Buzza, András Deák, Christian Kuttner, Estefania Gonzalez Solveyra, Lucia Pasquato, David Portehault, Hedi Mattoussi, Nicholas A Kotov, Eugenia Kumacheva, Kelley Heatley, Julian Bergueiro, Guillermo González, Wenming Tong, Muhammad Nawaz Tahir, Benjamin Abécassis, Oscar Rojas-Carrillo, Younan Xia, Martin Mayer, Davide Peddis
No abstract text is available yet for this article.
October 6, 2016: Faraday Discussions
Alberto Striolo, Jongwook Kim, Luis Liz-Marzán, Luciano Tadiello, Matthias Pauly, Catherine Murphy, Anna Roig, David Gracias, Younan Xia, Javier Reguera, Axel Mueller, Kevin Critchley, Mathias Brust, Leonardo Scarabelli, Martin Mayer, Matthias Thiele, Martin Buzza, András Deák, Ana Maria Bago Rodriguez, Christian Kuttner, Heiko Wolf, Euan Kay, Antonio Stocco, David Portehault, Hedi Mattoussi, Kelley Heatley, Eugenia Kumacheva, Guillermo González, Christoph Hanske, Wenming Tong, Muhammad Nawaz Tahir, Benjamin Abécassis, Steve Granick, Etienne Duguet, Alla Synytska, Krassimir Velikov
No abstract text is available yet for this article.
October 6, 2016: Faraday Discussions
Alberto Striolo, Francois Sicard, Luis Liz-Marzán, Catherine Murphy, Anna Roig, Axel Mueller, Javier Reguera, Yu Zhou, Mathias Brust, Leonardo Scarabelli, Luciano Tadiello, Antoine Thill, Irene Yarovsky, Martin Mayer, M Arturo López-Quintela, Christian Kuttner, Estefania Gonzalez Solveyra, Heiko Wolf, Euan Kay, Lucia Pasquato, David Buceta, David Portehault, Hedi Mattoussi, Guillermo González, Roland Faller, David French, Benjamin Abécassis, Molly Stevens, Younan Xia, Richard Jones, Marcin Grzelczak, Matthew Penna, Calum Drummond
No abstract text is available yet for this article.
October 6, 2016: Faraday Discussions
Hedy S Wald
No abstract text is available yet for this article.
October 4, 2016: JAMA: the Journal of the American Medical Association
Tawnya Bosko, Kathryn Wilson
Purpose The purpose of this paper is to assess the relationship between patient satisfaction and a variety of clinical quality measures in an ambulatory setting to determine if there is significant overlap between patient satisfaction and clinical quality or if they are separate domains of overall physician quality. Assessing this relationship will help to determine whether there is congruence between different types of clinical quality performance and patient satisfaction and therefore provide insight to appropriate financial structures for physicians...
October 10, 2016: Journal of Health Organization and Management
Asma Beltifa, Mohamed Ali Borgi, Anouar Ferieni, Abdelfettah Elfekih, Hedi Ben Mansour, Mohamed Sallah Allagui
In the present study, adult, healthy male Wistar rats (120 ± 10 g) were pre-treated by intragastric administration of cerium chloride (CeCl3) 10 mg/kg (BW) each day during 60 days. Control animal were treated with omega 3, a polyunsaturated fatty acid (ω-3), by an intragastric administration at 10 mg/kg of BW for 60 days. Our results showed that CeCl3-induced alterations in all tested oxidative stress markers. In fact, CeCl3-induced the increase the level of both the creatinine concentration and the expression of lactate dehydrogenase, alkaline phosphatase, and transaminase activities in serum...
October 2, 2016: Environmental Science and Pollution Research International
Hedy Kober, Judson A Brewer, Keri L Height, Rajita Sinha
Stress and negative affect are known contributors to drug use and relapse, and several known treatments for addictions include strategies for managing them. In the current study, we administered a well-established stress provocation during functional magnetic resonance imaging (fMRI) to 23 participants who completed either mindfulness training (MT; N=11) or the American Lung Association's Freedom From Smoking (FFS; N=12), which is a cognitive-behavioral treatment (CBT) for smoking cessation. Across the entire sample, we found that stress reactivity in several brain regions including the amygdala and anterior/mid insula was related to reductions in smoking after treatment, as well as at 3-month post-treatment follow-up...
September 28, 2016: NeuroImage
Gerry Oster, Sean D Sullivan, Mehul R Dalal, Mahmood R Kazemi, Maria Rojeski, Carol H Wysham, Jennifer Sung, Bryan Johnstone, Anna M G Cali, L J Wei, Louise Traylor, Henry Anhalt, Michelle Hull, John Van Vleet, Luigi F Meneghini
OBJECTIVE: This study aims to compare the effectiveness of insulin glargine 300 U/mL (Gla-300) with its accompanying patient support program with that of other basal insulin and available patient support programs in patients with type 2 diabetes (T2D) in a real-world setting in terms of achieving HEDIS (Healthcare Effectiveness Data and Information Set) individualized glycemic targets without documented symptomatic hypoglycemia. STUDY DESIGN AND METHODS: Achieve Control is a US-based, multicenter, randomized, open-label, active-controlled, parallel group pragmatic Phase IV trial in insulin-naïve patients with T2D uncontrolled on ≥2 oral antidiabetes drugs (OAD) and/or glucagon-like peptide-1 receptor antagonists (GLP-1 RA)...
October 3, 2016: Postgraduate Medicine
David Rice, Kari Chansky, Anna Nowak, Harvey Pass, Hedy Kindler, Lynn Shemanski, Isabelle Opitz, Sergi Call Caja, Seiki Hasegawa, Kemp Kernstine, Cansel Atinkaya, Federico Rea, Philippe Nafteux, Valerie Rusch
INTRODUCTION: Nodal categories for malignant pleural mesothelioma (MPM) are derived from the lung cancer staging system and have not been adequately validated. The International Association for the Study of Lung Cancer (IASLC) developed a multinational database to generate evidence-based recommendations to inform the 8(th) edition of the tumor, node metastasis classification of MPM. METHODS: Data from 29 centers were entered prospectively (n=1,566) or by transfer of retrospective data (n=1,953)...
September 23, 2016: Journal of Thoracic Oncology
Anna K Nowak, Kari Chansky, David C Rice, Harvey I Pass, Hedy L Kindler, Lynn Shemanski, Andrea Billé, Robert Rintoul, Hasan F Batirel, Charles F Thomas, Joseph Friedberg, Susana Cedres, Marc de Perrot, Valerie W Rusch
INTRODUCTION: Current T component for malignant pleural mesothelioma (MPM) has been predominantly informed by surgical datasets and consensus. The International Association for the Study of Lung Cancer undertook revision of the 7(th) Edition staging system for MPM with the goal of developing recommendations for the 8(th) edition. METHODS: Data elements including detailed T descriptors were developed by consensus. Tumor thickness at three pleural levels was also recorded...
September 23, 2016: Journal of Thoracic Oncology
Valerie W Rusch, Kari Chansky, Hedy L Kindler, Anna K Nowak, Harvey I Pass, David C Rice, Lynn Shemanski, Françoise Galateau-Sallé, Brian C McCaughan, Takashi Nakano, Enrico Ruffini, Jan P van Meerbeeck, Masahiro Yoshimura
INTRODUCTION: The M component and TNM stage groupings for malignant pleural mesothelioma (MPM) have been empirical. The International Association for the Study of Lung Cancer developed a multinational database to propose evidence-based revisions for the eighth edition of the TNM classification of MPM. METHODS: Data from 29 centers were submitted either electronically or by transfer of existing institutional databases. The M component as it currently stands was validated by confirming sufficient discrimination (by Kaplan-Meier analysis) with respect to overall survival (OS) between the clinical M0 (cM0) and cM1 categories...
September 28, 2016: Journal of Thoracic Oncology
Gad Rennert, Mila Pinchev, Naomi Gronich, Walid Saliba, Anath Flugelman, Idit Lavi, Hadassah Goldberg, Georgeta Fried, Mariana Steiner, Arie Bitterman, Keren Landsman, Hedy Rennert
PURPOSE: Bisphosphonates are used for treatment or prevention of osteoporosis and of bone metastases. The use of oral bisphosphonates was suggested to be associated with reduced risk of developing breast cancer and their positive influence on breast cancer survival was only demonstrated with third generation bisphosphonates. We studied the association of use of oral bisphosphonates after breast cancer diagnosis on overall and breast cancer survival. EXPERIMENTAL DESIGN: A nested case-control analysis was performed using data from the population-based Breast Cancer in Northern Israel Study (BCINIS)...
September 28, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Sameh Ghroubi, Islem Feki, Hedi Chelly, Mohamed Habib Elleuch
OBJECTIVE: The goal of this study was to evaluate the different neuropsychological and behavioral disorders of patients with traumatic brain injury (TBI) and to study their correlations with the epidemiological and neurotraumatic characteristics. MATERIAL/PATIENTS AND METHODS: It was a cross-sectional study including 30 patients with TBI conducted in the physical medicine and rehabilitation department. The analysis of memory impairment was performed by the (MMS) and the (GOAT) tests...
September 2016: Annals of Physical and Rehabilitation Medicine
Melody Tran, Pin Xiang, Karen L Rascati, Eileen M Stock, Paul J Godley, Amber Coleman, Michael R Bogart, Richard H Stanford
BACKGROUND: Suboptimal treatment of exacerbations is a major concern in management of chronic obstructive pulmonary disease (COPD). The Pharmacotherapy Management of COPD Exacerbation (PCE) Healthcare Effectiveness Data and Information Set (HEDIS) measure is a quality measure included by the National Committee for Quality Assurance that focuses on appropriate use of steroids and bronchodilators during an acute COPD exacerbation. There is limited evidence evaluating predictors of this quality measure, as well as its association with hospital readmission and cost outcomes...
October 2016: Journal of Managed Care & Specialty Pharmacy
Hanneke Basart, Hedy A van Oers, Emma C Paes, Corstiaan C Breugem, J Peter W Don Griot, Chantal M A M van der Horst, Lotte Haverman, Raoul C Hennekam
This patient-reported outcome (PRO) study reports on 102 children with Robin sequence (RS) and their parents. There has been differentiated between those with isolated RS and those with RS as part of a syndrome, and take various treatments into account. All RS families from an earlier described cohort were invited to participate. Parents and RS children completed online questionnaires regarding health-related quality of life (HRQoL), satisfaction with appearance, parental distress, and RS specific topics. Results were compared with the Dutch norm population if available...
September 20, 2016: American Journal of Medical Genetics. Part A
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