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https://www.readbyqxmd.com/read/28431058/additional-electrodes-on-the-quartet%C3%A2-lv-lead-provide-more-programmable-pacing-options-than-bipolar-and-tripolar-equivalents
#1
David O'Donnell, Johannes Sperzel, Bernard Thibault, Christopher A Rinaldi, Carlo Pappone, Klaus-Jürgen Gutleben, Christopher Leclercq, Hedi Razavi, Kyungmoo Ryu, Luke C Mcspadden, Avi Fischer, Gery Tomassoni
Aims: The aim of this study was to evaluate any benefits to the number of viable pacing vectors and maximal spatial coverage with quadripolar left ventricular (LV) leads when compared with tripolar and bipolar equivalents in patients receiving cardiac resynchronization therapy (CRT). Methods and Results: A meta-analysis of five previously published clinical trials involving the Quartet™ LV lead (St Jude Medical, St Paul, MN, USA) was performed to evaluate the number of viable pacing vectors defined as capture thresholds ≤2...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28398117/reconstructing-the-times-of-past-and-future-personal-events
#2
Hédi Ben Malek, Fabrice Berna, Arnaud D'Argembeau
Humans have the remarkable ability to mentally travel through past and future times. However, while memory for the times of past events has been much investigated, little is known about how imagined future events are temporally located. Using a think-aloud protocol, we found that the temporal location of past and future events is rarely directly accessed, but instead mostly relies on reconstructive and inferential strategies. References to lifetime periods and factual knowledge (about the self, others, and the world) were most frequently used to determine the temporal location of both past and future events...
April 11, 2017: Memory
https://www.readbyqxmd.com/read/28382934/connecting-myelin-related-and-synaptic-dysfunction-in-schizophrenia-with-snp-rich-gene-expression-hubs
#3
Hedi Hegyi
Combining genome-wide mapping of SNP-rich regions in schizophrenics and gene expression data in all brain compartments across the human life span revealed that genes with promoters most frequently mutated in schizophrenia are expression hubs interacting with far more genes than the rest of the genome. We summed up the differentially methylated "expression neighbors" of genes that fall into one of 108 distinct schizophrenia-associated loci with high number of SNPs. Surprisingly, the number of expression neighbors of the genes in these loci were 35 times higher for the positively correlating genes (32 times higher for the negatively correlating ones) than for the rest of the ~16000 genes...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28381775/fatty-acid-esterification-with-polyols-over-acidic-montmorillonite
#4
Asma Chaari, Soumaya Bouguerra Neji, Mouhamed Hedi Frikha
The production of fatty acid esters from stearic, oleic, and palmitic acids and polyols (ethylene glycol and glycerol) was investigated in this work. A series of montmorillonite-based clays catalysts (KSF, KSF/0, KP10, and K10), having different physicochemical properties, were used as acidic catalysts. The influence of the specific surface area and the acidity of the catalysts on the esterification rate were explored. The best catalytic activities were obtained with KSF catalyst. The optimization of various factors on the reaction was also studied, including catalyst concentration, reaction temperature and molar ratio (polyol /fatty acid)...
April 4, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28359094/birth-weight-in-different-etiologies-of-disorders-of-sex-development
#5
Sukran Poyrazoglu, Feyza Darendeliler, S Faisal Ahmed, Ieuan Hughes, Jillian Bryce, Jipu Jiang, Martina Rodie, Olaf Hiort, Sabine E Hannema, Silvano Bertelloni, Lidka Lisa, Tulay Guran, Martine Cools, An Desloovere, Hedi L Claahsen-van der Grinten, Anna Nordenstrom, Paul-Martin Holterhus, Birgit Kohler, Marek Niedziela, Nils Krone
Context: It is well established that boys are heavier than girls at birth. Although the cause of birth weight (BW) difference is unknown, it has been proposed that it could be generated from prenatal androgen action. Objective: The aim of the current study was to determine the BW of children with disorders of sex development (DSD) of different etiologies and to evaluate the effects of androgen action on BW. Methods: Data regarding diagnosis, BW, gestational age, karyotype, and concomitant conditions were collected from the International Disorders of Sex Development (I-DSD) Registry (www...
March 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28358905/violent-relationships-at-the-social-ecological-level-a-multi-mediation-model-to-predict-adolescent-victimization-by-peers-bullying-and-depression-in-early-and-late-adolescence
#6
Xavier Oriol, Rafael Miranda, Alberto Amutio, Hedy C Acosta, Michelle C Mendoza, Javier Torres-Vallejos
BACKGROUND: From the social-ecological perspective, exposure to violence at the different developmental levels is fundamental to explain the dynamics of violence and victimization in educational centers. The following study aims at analyzing how these relationships are produced in the Peruvian context, where structural violence situations exist. METHODS: A multi-mediation structural model with 21,416 Peruvian adolescents (M = 13.69; SD = 0.71) was conducted to determine the influence of violence in the school environment on violence perceived within school and violence exercised by teachers...
2017: PloS One
https://www.readbyqxmd.com/read/28358156/selective-synthesis-of-mono-and-bis-butenolide-%C3%AE-aminomethyl-adducts
#7
Arbia Talbi, Aïcha Arfaoui, Talia Bsaibess, Mohamed Lotfi Efrit, Anne Gaucher, Damien Prim, Hédi M Rabet
The selective installation of α-methylamine residues at the butenolide core is described using α-bromomethylene-γ-butenolide and primary as well as secondary amines in methanol at 0 °C. The preparation of mono- and bis-butenolide α-adducts is described. Bis-γ-butenolide adducts as well as mono α-aminomethyl-γ-butenolides can be selectively obtained depending on the nature of the reacting primary amine. In contrast, the use of secondary amines allows two different pathways leading either to the expected amino derivatives or to the formation of a C-O bond...
April 11, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28327771/the-roles-of-surface-chemistry-dissolution-rate-and-delivered-dose-in-the-cytotoxicity-of-copper-nanoparticles
#8
Miao Shi, Karen L de Mesy Bentley, Goutam Palui, Hedi Mattoussi, Alison Elder, Hong Yang
The understanding of nanoparticle (NP) cytotoxicity is challenging because of incomplete information about physicochemical changes particles undergo once they come into contact with biological fluids. It is therefore essential to characterize changes in NP properties to better understand their biological fate and effects in mammalian cells. In this paper, we present a study on the effect of particle surface oxidation and dissolution rates of Cu NPs. Particle dissolution, cell-associated Cu doses, and oxidative stress responses in A549 luciferase reporter cells were examined for Cu NPs modified with mercaptocarboxylic acids with different carbon chain lengths and a thiotic acid appended-PEG ligand (TA)...
April 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/28322422/use-it-or-lose-it-cognitive-activity-as-a-protec-tive-factor-for-cognitive-decline-associated-with-alzheimer-s-disease
#9
Panagiota Mistridis, Jutta Mata, Stefan Neuner-Jehle, Jean-Marie Annoni, Andreas Biedermann, Irene Bopp-Kistler, Dominique Brand, Andrea Brioschi Guevara, Hedi Decrey-Wick, Jean-François Démonet, Ulrich Hemmeter, Reto W Kressig, Brian Martin, Luca Rampa, Egemen Savaskan, Andreas Stuck, Philipp Tschopp, Dina Zekry, Andreas Monsch
Because of the worldwide aging of populations, Alzheimer's disease and other dementias constitute a devastating experience for patients and families as well as a major social and economic burden for both healthcare systems and society. Multiple potentially modifiable cardiovascular and lifestyle risk factors have been associated with this disease. Thus, modifying these risk factors and identifying protective factors represent important strategies to prevent and delay disease onset and to decrease the social burden...
March 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28300508/promoting-safety-in-hypnosis-a-clinical-instrument-for-the-assessment-of-alertness
#10
Hedy A Howard
Hypnosis has long demonstrated its power to facilitate various approaches to psychotherapy. Like other potent modalities, hypnosis may produce unwanted effects. Although its negative sequelae are usually mild and transient, more serious complications may occur. Recently, attention has been drawn to the powerful role of failures of dehypnosis or alerting/realerting in producing unwanted effects. Traditionally, alerting has been viewed as a relatively uncomplicated process that requires little more than the simple suggestion that the subject will return or awaken from trance, and exiting from trance has generally been considered the cessation of the phenomena suggested during induction and thereafter...
April 2017: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/28272093/elevated-procalcitonin-is-associated-with-bacterial-infection-during-acute-liver-failure-only-when-unrelated-to-acetaminophen-intoxication
#11
Maxime Mallet, Maela Haq, Simona Tripon, Maguy Bernard, Hedi Benosman, Dominique Thabut, Marika Rudler
AIM: The aim of this study was to evaluate the accuracy of procalcitonin (PCT) in predicting bacterial infection and survival without transplantation upon admission in the ICU for acute liver failure (ALF). PATIENTS AND METHODS: From January 2009 until October 2015, all cases of ALF patients admitted in our ICU were retrospectively reviewed and included in the study if the PCT level upon admission was available. Patients with pre-existing liver pathology or ALF in a context of already advanced multiorgan failure were excluded...
March 7, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28264855/structural-alteration-of-ompr-as-a-source-of-ertapenem-resistance-in-a-ctx-m-15-producing-escherichia-coli-o25b-h4-st131-clinical-isolate
#12
Hervé Dupont, Pascaline Choinier, David Roche, Sandine Adiba, Megan Sookdeb, Catherine Branger, Erick Denamur, Hedi Mammeri
In this study, an ertapenem-non-susceptible Escherichia coli isolate was investigated to determine the genetic basis for its carbapenem resistance phenotype. This clinical strain was recovered from a patient that received, one year ago, ertapenem to treat a cholangitis due to a carbapenem-susceptible extended-spectrum β-lactamase (ESBL)-producing E. coli isolate. Whole-genome sequencing of these strains was performed using Illumina and single molecule real-time sequencing technologies. It revealed that they belonged to the ST131 clonal group, had the predicted O25b:H4 serotype, and produced the CTX-M-15 and TEM-1 β-lactamases...
March 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28250656/new-cytotoxic-cembranoid-from-indonesian-soft-coral-sarcophyton-sp
#13
Hedi Indra Januar, Neviaty Putri Zamani, Dedi Soedharma, Ekowati Chasanah
CONTEXT: Sarcophyton is a soft coral species that contains various secondary metabolites with cytotoxic activity. The production of cytotoxic compounds in soft corals is suggested as their allelochemical to win space competition. Therefore, if a particular soft coral species dominates a reef area, it may suggest to contain interesting bioactive compounds. AIMS: This research aimed to characterize the cytotoxic compounds in dominant soft coral species (Sarcophyton sp...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28241829/real-time-qrs-complex-detection-using-dfa-and-regular-grammar
#14
Salah Hamdi, Asma Ben Abdallah, Mohamed Hedi Bedoui
BACKGROUND: The sequence of Q, R, and S peaks (QRS) complex detection is a crucial procedure in electrocardiogram (ECG) processing and analysis. We propose a novel approach for QRS complex detection based on the deterministic finite automata with the addition of some constraints. This paper confirms that regular grammar is useful for extracting QRS complexes and interpreting normalized ECG signals. A QRS is assimilated to a pair of adjacent peaks which meet certain criteria of standard deviation and duration...
February 28, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28221229/another-perspective-on-a-patient-s-perspective
#15
Hedy S Wald
No abstract text is available yet for this article.
March 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28219997/phase-resolved-pulse-propagation-through-metallic-photonic-crystal-slabs-plasmonic-slow-light
#16
Anja Schönhardt, Dietmar Nau, Christina Bauer, André Christ, Hedi Gräbeldinger, Harald Giessen
We characterized the electromagnetic field of ultra-short laser pulses after propagation through metallic photonic crystal structures featuring photonic and plasmonic resonances. The complete pulse information, i.e. the envelope and phase of the electromagnetic field, was measured using the technique of cross-correlation frequency resolved optical gating. In good agreement, measurements and scattering matrix simulations show a dispersive behaviour of the spectral phase at the position of the resonances. Asymmetric Fano-type resonances go along with asymmetric phase characteristics...
March 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28196459/care-provision-and-prescribing-practices-of-physicians-treating-children-and-adolescents-with-adhd
#17
Ayush Patel, Rohan Medhekar, Melissa Ochoa-Perez, Rajender R Aparasu, Wenyaw Chan, Jeffrey T Sherer, Joy Alonzo, Hua Chen
OBJECTIVE: Care provision and prescribing practices of physicians treating children with attention-deficit hyperactivity disorder (ADHD) were compared. METHODS: A retrospective cohort study was conducted with the 1995-2010 General Electric Centricity Electronic Medical Record database. The sample included children (≤18 years) with newly diagnosed ADHD (ICD-9-CM code 314.XX) who received a prescription for a stimulant or atomoxetine. Identification of comorbid psychiatric disorders, duration from initial ADHD diagnosis to treatment, prescription of other psychotropic medications, and follow-up care during the ten months after the ADHD treatment initiation were compared across provider type (primary care physicians [PCPs], child psychiatrists, and physicians with an unknown specialty)...
February 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28188257/validation-of-progression-free-survival-as-a-surrogate-endpoint-for-overall-survival-in-malignant-mesothelioma-analysis-of-cancer-and-leukemia-group-b-and-north-central-cancer-treatment-group-alliance-trials
#18
Xiaofei Wang, Xiaoyi Wang, Lydia Hodgson, Stephen L George, Daniel J Sargent, Nate R Foster, Apar Kishor Ganti, Thomas E Stinchcombe, Jeffrey Crawford, Robert Kratzke, Alex A Adjei, Hedy L Kindler, Everett E Vokes, Herbert Pang
PURPOSE: The aim of this study was to investigate whether progression-free survival (PFS) can be considered a surrogate endpoint for overall survival (OS) in malignant mesothelioma. MATERIALS AND METHODS: Individual data were collected from 15 Cancer and Leukemia Group B (615 patients) and 2 North Central Cancer Treatment Group (101 patients) phase II trials. The effects of 5 risk factors for OS and PFS, including age, histology, performance status (PS), white blood cell count, and European Organisation for Research and Treatment of Cancer (EORTC) risk score, were used in the analysis...
February 10, 2017: Oncologist
https://www.readbyqxmd.com/read/28183138/overall-survival-and-clinical-characteristics-of-brca-mutation-carriers-with-stage-i-ii-pancreatic-cancer
#19
Talia Golan, Tal Sella, Eileen M O'Reilly, Matthew H G Katz, Ron Epelbaum, David P Kelsen, Ayelet Borgida, Hannah Maynard, Hedy Kindler, Eitan Friedmen, Milind Javle, Steven Gallinger
BACKGROUND: BRCA1/BRCA2 germ line (GL) mutation carriers with pancreatic adenocarcinoma (PDAC) may have distinct outcomes. We recently described an apparent more favourable prognosis of surgically resected BRCA-associated PDAC patients in a single-arm, uncontrolled, retrospective study. However, the prognostic impact of GL BRCA1/2 mutations in surgically resected PDAC has not been compared with a matched control population. METHODS: A larger multi-centre, case-control retrospective analysis was performed...
March 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28150366/correlation-between-umbilical-resistance-index-and-fetal-growth-pilot-study
#20
Mehdi Kehila, Omar Touhami, Rim Ben Hmid, Hassine Saber Abouda, Khlifi Abdeljelil, Amira Ayachi, Mechaal Mourali, Hédi Khairi, Mohamed Badis Chanoufi
AIM: To investigate normal pregnancies to determine whether there is a relationship between umbilical resistance and fetal growth. METHODS: This prospective study was conducted in three academic departments. Third trimester routine prenatal ultrasonography was used to estimate fetal weight and measure umbilical resistance index (RI). After delivery the birthweight was noted, along with the time interval between the ultrasound and the delivery, and then the weekly weight gain was calculated...
February 2, 2017: Journal of Obstetrics and Gynaecology Research
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