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Troy Puar, Manon Engels, Antonius E van Herwaarden, Fred C G J Sweep, Christina Hulsbergen-van de Kaa, Karin Kamphuis-van Ulzen, Vasileios Chortis, Wiebke Arlt, Nike Stikkelbroeck, Hedi L Claahsen-van der Grinten, Ad R M M Hermus
CONTEXT: Recurrence of hypercortisolism in patients after bilateral adrenalectomy for Cushing's disease is extremely rare. PATIENT: We present a rare case of a 27-year-old man who previously underwent bilateral adrenalectomy for Cushing's disease with complete clinical resolution. Cushingoid features recurred 12 years later, along with bilateral testicular enlargement. Hormonal tests confirmed ACTH-dependent Cushing's. Surgical resection of the testicular tumors led to clinical and biochemical remission...
November 30, 2016: Journal of Clinical Endocrinology and Metabolism
Austin B Schwartz, Anshika Kapur, Wentao Wang, Zhenbo Huang, Erminia Fardone, Goutam Palui, Hedi Mattoussi, Debra Ann Fadool
Venom-derived ion channel inhibitors have strong channel selectivity, potency, and stability; however, tracking delivery to their target can be challenging. Herein, we utilized luminescent quantum dots (QDs) conjugated to margatoxin (MgTx) as a traceable vehicle to target a voltage-dependent potassium channel, Kv1.3, which has a select distribution and well characterized role in immunity, glucose metabolism, and sensory ability. We screened both unconjugated (MgTx) and conjugated MgTx (QD-MgTx) for their ability to inhibit Shaker channels Kv1...
November 8, 2016: Journal of Neurochemistry
Hedy Lee Kindler
No abstract text is available yet for this article.
October 2016: Journal of Oncology Practice
Hedi Karoui, Chris Ritchie
Three organoboron functionalized polyoxometalates have been synthesized using Schiff base chemistry including a boronic acid, its methyl ester and its trimethylene glycol ester. The compounds have been characterized in the solid state by single crystal diffraction (XRD), FT-IR and elemental analysis and in solution using (1)H NMR spectroscopy.
November 16, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Imen Mahjoubi, Amani Kallel, Mohamed Hédi Sbaï, Bochra Ftouhi, Meriam Ben Halima, Zeineb Jemaa, Moncef Feki, Hedia Slimane, Riadh Jemaa, Naziha Kaabachi
BACKGROUND & OBJECTIVES: The impact of several environmental and genetic factors on diabetes is well documented. Though the association between the vitamin D receptor (VDR) gene polymorphisms and type 2 diabetes mellitus (T2DM) has been analyzed in different ethnic groups, the results have been inconsistent. The aim of this study was to evaluate the possible association between VDR FokI polymorphism and genetic susceptibility to T2DM in Tunisian population. METHODS: A total of 439 unrelated patients with T2DM and 302 healthy controls were included in the study...
July 2016: Indian Journal of Medical Research
Gunjan L Shah, Aaron Winn, Pei-Jung Lin, Andreas Klein, Kellie A Sprague, Hedy P Smith, Rachel Buchsbaum, Joshua T Cohen, Kenneth B Miller, Raymond Comenzo, Susan K Parsons
Comorbidity is more common in older patients and can increase the cost of care by increasing toxicity. Using the SEER-Medicare database from 2000 to 2007, we examined the costs and life-year benefit of Auto-HSCT for MM patients over the age of 65 by evaluating the difference over time relative to comorbidity burden. One hundred ten patients had an Auto-HSCT in the early time period (2000-2003) and 160 in the late time period (2004-2007). Patients were divided by a Charlson Comorbidity Index (CCI) of 0 or greater than 1 (CCI1+)...
2016: Bone Marrow Research
Rateb Kochbati, Hedi Rbai, Marouene Jlailia, Hassen Makhlouf, Abderrazak Bouguira, Med Samir Daghfous
INTRODUCTION: Aseptic loosening is the main long-term complication and indicates total hip replacement failure. There are many and often intricate causes for aseptic loosening. Incorrect placement of the implants is the most incriminated factor. Other patient and implant related factors may also predispose to loosening but to various degrees. METHODS: We conducted a retrospective study of 64 cases with aseptic loosening of total hip prosthesis to individuate patient, implant type and surgical technique related factors leading to aseptic loosening and to provide recommendations to minimize this risk...
2016: Pan African Medical Journal
Anna Hedy Walsh
No abstract text is available yet for this article.
October 2016: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
Judy H Ng, Katherine Sobel, Lindsey Roth, Sepheen C Byron, Megan C Lindley, Shannon Stokley
CONTEXT: An estimated 79 million Americans are infected with human papillomavirus (HPV). Vaccination can reduce the burden of infection and HPV-associated cancers; yet, vaccination rates remain low. Little is known about why some health plans achieve higher vaccination rates. OBJECTIVE: This study sought to identify strategies used by higher-performing health plans to support HPV vaccination. DESIGN: We used 2013 data from the Healthcare Effectiveness Data and Information Set (HEDIS) Human Papillomavirus Vaccine for Female Adolescents measure to identify high-performing plans...
October 28, 2016: Journal of Public Health Management and Practice: JPHMP
Sunny C Y Jeng, Hedy H Y Chan, Evan P Booy, Sean A McKenna, Peter J Unrau
The effective tracking and purification of biological RNAs and RNA protein complexes is currently challenging. One promising strategy to simultaneously address both of these problems is to develop high-affinity RNA aptamers against taggable small molecule fluorophores. RNA Mango is a 39-nucleotide, parallel-stranded G-quadruplex RNA aptamer motif that binds with nanomolar affinity to a set of thiazole orange (TO1) derivatives while simultaneously inducing a 10(3)-fold increase in fluorescence. We find that RNA Mango has a large increase in its thermal stability upon the addition of its TO1-Biotin ligand...
December 2016: RNA
Wickii T Vigneswaran, Diana Y Kircheva, Vijayalakshimi Ananthanarayanan, Sydeaka Watson, Qudsia Arif, Amy Durkin Celauro, Hedy L Kindler, Aliya N Husain
BACKGROUND: Macroscopic complete surgical resection with adjuvant chemotherapy can provide a survival advantage in patients with malignant pleural mesothelioma (MPM). Patients with nonepithelioid histology are largely excluded from such radical operations even though they might benefit. The degree of epithelioid differentiation varies in biphasic histology. We report the outcomes of pleurectomy and decortication and the effect of epithelioid differentiation on overall survival of patients with MPM...
October 17, 2016: Annals of Thoracic Surgery
Sebastiaan J M Vreeswijk, Hedi L Claahsen, Wilfred A Borstlap, Mark P Hendriks
No abstract text is available yet for this article.
November 2016: European Journal of Anaesthesiology
Ferdaous Maâtouk, Mouna Maâtouk, Karima Bekir, Houcine Barhoumi, Abderrazak Maaref, Hedi Ben Mansour
In this work we report the development of an electrochemical DNA biosensor with high sensitivity for mercury ion detection. A new matrix based on gold nanoparticles (AuNPs)-glutathione (GSH)/cysteine was investigated. The interaction between DNA oligonucleotides and Hg(2+) ions followed by the formation of Thymine-Hg(2+)-Thymine (T-Hg(2+)-T) structures was quantified using different electrochemical methods. It has been shown that the electrochemical impedance spectroscopy (EIS) measurements and the differential pulse voltammetry (DPV) confirmed the specific interaction between the oligonucleotide receptor layer and the Hg(2+) ions...
October 2016: Journal of Water and Health
Christopher Piorkowski, Ole-A Breithardt, Hedi Razavi, Yelena Nabutovsky, Stuart P Rosenberg, Craig D Markovitz, Arash Arya, Sascha Rolf, Silke John, Jedrzej Kosiuk, Eric Olson, Charlotte Eitel, Yan Huo, Michael Döring, Sergio Richter, Kyungmoo Ryu, Thomas Gaspar, Frits W Prinzen, Gerhard Hindricks, Philipp Sommer
AIMS: In times of evolving cardiac resynchronization therapy, intra-procedural characterization of left ventricular (LV) mechanical activation patterns is desired but technically challenging with currently available technologies. In patients with normal systolic function, we evaluated the feasibility of characterizing LV wall motion using a novel sensor-based, real-time tracking technology. METHODS AND RESULTS: Ten patients underwent simultaneous motion and electrical mapping of the LV endocardium during sinus rhythm using electroanatomical mapping and navigational systems (EnSite™ NavX™ and MediGuide™, SJM)...
October 12, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Alberto Striolo, Jongwook Kim, Catherine Murphy, Luis Liz-Marzán, Joerg Lahann, Javier Reguera, Yu Zhou, Mathias Brust, Antoine Thill, Leonardo Scarabelli, Tobias A F König, Martin Buzza, Christian Kuttner, Estefania Gonzalez Solveyra, Heiko Wolf, Jan Vermant, Matthias Pauly, Andrew Harvie, Lucia Pasquato, Antonio Stocco, Hedi Mattoussi, Eugenia Kumacheva, Kelley Heatley, Christoph Hanske, Roland Faller, David French, Andrei Honciuc, Bernard Binks, Francois Sicard
No abstract text is available yet for this article.
October 6, 2016: Faraday Discussions
Andrea Castelli, Alberto Striolo, Anna Roig, Catherine Murphy, Javier Reguera, Luis Liz-Marzán, Axel Mueller, Kevin Critchley, Yu Zhou, Mathias Brust, Antoine Thill, Leonardo Scarabelli, Luciano Tadiello, Tobias A F König, Beate Reiser, M Arturo López-Quintela, Martin Buzza, András Deák, Christian Kuttner, Estefania Gonzalez Solveyra, Lucia Pasquato, David Portehault, Hedi Mattoussi, Nicholas A Kotov, Eugenia Kumacheva, Kelley Heatley, Julian Bergueiro, Guillermo González, Wenming Tong, Muhammad Nawaz Tahir, Benjamin Abécassis, Oscar Rojas-Carrillo, Younan Xia, Martin Mayer, Davide Peddis
No abstract text is available yet for this article.
October 6, 2016: Faraday Discussions
Alberto Striolo, Jongwook Kim, Luis Liz-Marzán, Luciano Tadiello, Matthias Pauly, Catherine Murphy, Anna Roig, David Gracias, Younan Xia, Javier Reguera, Axel Mueller, Kevin Critchley, Mathias Brust, Leonardo Scarabelli, Martin Mayer, Matthias Thiele, Martin Buzza, András Deák, Ana Maria Bago Rodriguez, Christian Kuttner, Heiko Wolf, Euan Kay, Antonio Stocco, David Portehault, Hedi Mattoussi, Kelley Heatley, Eugenia Kumacheva, Guillermo González, Christoph Hanske, Wenming Tong, Muhammad Nawaz Tahir, Benjamin Abécassis, Steve Granick, Etienne Duguet, Alla Synytska, Krassimir Velikov
No abstract text is available yet for this article.
October 6, 2016: Faraday Discussions
Alberto Striolo, Francois Sicard, Luis Liz-Marzán, Catherine Murphy, Anna Roig, Axel Mueller, Javier Reguera, Yu Zhou, Mathias Brust, Leonardo Scarabelli, Luciano Tadiello, Antoine Thill, Irene Yarovsky, Martin Mayer, M Arturo López-Quintela, Christian Kuttner, Estefania Gonzalez Solveyra, Heiko Wolf, Euan Kay, Lucia Pasquato, David Buceta, David Portehault, Hedi Mattoussi, Guillermo González, Roland Faller, David French, Benjamin Abécassis, Molly Stevens, Younan Xia, Richard Jones, Marcin Grzelczak, Matthew Penna, Calum Drummond
No abstract text is available yet for this article.
October 6, 2016: Faraday Discussions
Hedy S Wald
No abstract text is available yet for this article.
October 4, 2016: JAMA: the Journal of the American Medical Association
Tawnya Bosko, Kathryn Wilson
Purpose The purpose of this paper is to assess the relationship between patient satisfaction and a variety of clinical quality measures in an ambulatory setting to determine if there is significant overlap between patient satisfaction and clinical quality or if they are separate domains of overall physician quality. Assessing this relationship will help to determine whether there is congruence between different types of clinical quality performance and patient satisfaction and therefore provide insight to appropriate financial structures for physicians...
October 10, 2016: Journal of Health Organization and Management
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