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https://www.readbyqxmd.com/read/28527909/binding-assay-for-characterization-of-protein-kinase-inhibitors-possessing-sub-picomolar-to-sub-millimolar-affinity
#1
Hedi Sinijarv, Shanshan Wu, Taavi Ivan, Kaido Viht, Asko Uri
High demand for inhibitors regulating the activity of protein kinases has stimulated the quest for high throughput and reliable compound screening assays. Here we introduce a method applying a non-metal photoluminescent probe ARC-Lum(Fluo) for determination of dissociation constants of competitive inhibitors of protein kinases. Employing a single probe instead of a combination of antibody and fluorescent tracer makes the assay simpler, cheaper, and more accurate than several other inhibitor-screening technologies...
May 17, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28515149/pyruvate-kinase-inhibits-proliferation-during-postnatal-cerebellar-neurogenesis-and-suppresses-medulloblastoma-formation
#2
Katherine Tech, Andrey P Tikunov, Hamza Farooq, A Sorana Morrissy, Jessica Meidinger, Taylor Fish, Sarah C Green, Hedi Liu, Yisu Li, Andrew J Mungall, Richard A Moore, Yussanne Ma, Steven Jm Jones, Marco A Marra, Matthew G Vander Heiden, Michael D Taylor, Jeffrey MacDonald, Timothy R Gershon
Aerobic glycolysis supports proliferation through unresolved mechanisms. We have previously shown that aerobic glycolysis is required for the regulated proliferation of cerebellar granule neuron progenitors (CGNPs), and for the growth of CGNP-derived medulloblastoma. Blocking the initiation of glycolysis via deletion of Hexokinase-2 (Hk2) disrupts CGNP proliferation and restricts medulloblastoma growth. Here, we assessed whether disrupting Pyruvate kinase-M (Pkm), an enzyme that acts in the terminal steps of glycolysis, would alter CGNP metabolism, proliferation and tumorigenesis...
May 17, 2017: Cancer Research
https://www.readbyqxmd.com/read/28509283/in-vivo-molecular-mri-of-icam-1-expression-on-endothelium-and-leukocytes-from-subacute-to-chronic-stages-after-experimental-stroke
#3
Lisette H Deddens, Geralda A F van Tilborg, Kajo van der Marel, Hedi Hunt, Annette van der Toorn, Max A Viergever, Helga E de Vries, Rick M Dijkhuizen
Molecular MRI allows in vivo detection of vascular cell adhesion molecules expressed on inflamed endothelium, which enables detection of specific targets for anti-neuroinflammatory treatment. We explored to what extent MR contrast agent targeted to intercellular adhesion molecule-1 (ICAM-1) could detect endothelial- and leukocyte-associated ICAM-1 expression at different stages after experimental stroke. Furthermore, we assessed potential interfering effects of ICAM-1-targeted contrast agent on post-stroke lesion growth...
May 16, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28508605/disorders-of-adrenal-steroidogenesis-impact-on-gonadal-function-and-sex-development
#4
Christiaan F Mooij, Antonius E van Herwaarden, Hedi L Claahsen-van der Grinten
A defect in adrenal steroidogenesis may cause a disorder of sex development (DSD). Importantly, DSD of adrenal origin is not restricted to a genital phenotype but is in most cases accompanied by mild to severe impairment in glucocorticoid and/or mineralocorticoid synthesis. If a patient is suspected of DSD of adrenal origin evaluation of glucocorticoid and mineralocorticoid metabolism is therefore essential to provide adequate medical care in the case of a severe and potentially life-threatening insufficiency...
December 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28508033/over-the-scope-clip-otsc-reduces-surgery-rate-in-the-management-of-iatrogenic-gastrointestinal-perforations
#5
Sherine Khater, Gabriel Rahmi, Guillaume Perrod, Elia Samaha, Hedi Benosman, Leila Abbes, Georgia Malamut, Christophe Cellier
Background and study aims Over-the-scope clip (OTSC) has been recently used in management of gastrointestinal perforations, but data on it are still limited. The aim of this study was to compare management of iatrogenic perforations before and after the OTSC was available in our endoscopy unit. Patients and methods We conducted a monocentric retrospective study from June 2007 to June 2015. All iatrogenic gastrointestinal perforations detected during endoscopy were included. Two time periods were compared in terms of surgery and mortality rates: before use of OTSC (June 2007 to June 2011) and after OTSC became available (June 2011 to June 2015)...
May 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28506096/response-to-the-cost-of-caring
#6
Aviad Haramati, Sian Cotton, Jamie S Padmore, Hedy S Wald, Peggy A Weissinger
No abstract text is available yet for this article.
May 16, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28480227/influence-of-sex-gender-and-race-on-responses-to-raltegravir-combined-with-tenofovir-emtricitabine-in-treatment-naive-human-immunodeficiency-virus-1-infected-patients-pooled-analyses-of-the-startmrk-and-qdmrk-studies
#7
Kathleen Squires, Linda-Gail Bekker, Christine Katlama, Yazdan Yazdanpanah, Yan Zhou, Anthony J Rodgers, Mark J DiNubile, Peter A Sklar, Randi Y Leavitt, Hedy Teppler
BACKGROUND: Antiretroviral therapy in human immunodeficiency virus (HIV)-infected women and blacks merits particular scrutiny because these groups have been underrepresented in clinical trials. METHODS: To document the effects of raltegravir across sex and racial lines, we conducted a pooled subgroup analysis of the efficacy and safety of raltegravir 400 mg BID plus tenofovir-emtricitabine by sex (women vs men) and self-identified race (black vs non-black) using phase 3 studies in treatment-naive patients...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28472479/kpc-3-producing-st167-escherichia-coli-from-mussels-bought-at-a-retail-market-in-tunisia
#8
Yosra Mani, Wejdene Mansour, Hedi Mammeri, Erick Denamur, Estelle Saras, Noureddine Boujâafar, Olfa Bouallègue, Jean-Yves Madec, Marisa Haenni
No abstract text is available yet for this article.
May 2, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28471601/prolactin-another-important-player-in-the-mosaic-of-autoimmunity
#9
Abdulla Watad, Howard Amital, Gali Aljadeff, Gisele Zandman-Goddard, Hedi Orbach, Yehuda Shoenfeld
No abstract text is available yet for this article.
September 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28468593/hyaluronan-binding-peptide-for-targeting-peritoneal-carcinomatosis
#10
Hideki Ikemoto, Prakash Lingasamy, Anne-Mari Anton Willmore, Hedi Hunt, Kaarel Kurm, Olav Tammik, Pablo Scodeller, Lorena Simón-Gracia, Venkata Ramana Kotamraju, Andrew M Lowy, Kazuki N Sugahara, Tambet Teesalu
Peritoneal carcinomatosis results from dissemination of solid tumors in the peritoneal cavity, and is a common site of metastasis in patients with carcinomas of gastrointestinal or gynecological origin. Peritoneal carcinomatosis treatment is challenging as poorly vascularized, disseminated peritoneal micro-tumors are shielded from systemic anticancer drugs and drive tumor regrowth. Here, we describe the identification and validation of a tumor homing peptide CKRDLSRRC (IP3), which upon intraperitoneal administration delivers payloads to peritoneal metastases...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28467113/efficacy-and-safety-of-insulin-glargine-300-u-ml-versus-insulin-glargine-100-u-ml-in-high-risk-and-low-risk-patients-with-type-2-diabetes-stratified-using-common-clinical-performance-measures
#11
Ildiko Lingvay, Jason Chao, Mehul R Dalal, Luigi F Meneghini
BACKGROUND: To determine whether previously reported reductions in hypoglycemia associated with insulin glargine 300 U/mL (Gla-300) compared with insulin glargine 100 U/mL (Gla-100) are impacted by patient risk category in type 2 diabetes (T2D), clinical performance measures based on the Healthcare Effectiveness Data and Information Set (HEDIS) were applied to patient-level data from the EDITION 2 and EDITION 3 clinical trials that compared Gla-300 and Gla-100. METHODS: In this post hoc analysis, patients were stratified as low risk (LR) if patients were <65 years old with no comorbidities derived from HEDIS (HbA1c target <7...
May 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28448781/assessment-of-clinical-pharmacy-interventions-to-reduce-outpatient-use-of-high-risk-medications-in-the-elderly
#12
Sarah C Weddle, A Shaun Rowe, Julie W Jeter, Rachel C Renwick, Shaunta' M Chamberlin, Andrea S Franks
BACKGROUND: Use of high-risk medications in the elderly (HRME) and drug-disease (Rx-DIS) interactions in the elderly, as defined by the Healthcare Effectiveness Data and Information Set (HEDIS) Measures, are significantly associated with mortality, hospital admission, and need for emergency care. No published studies to date evaluate interventions to reduce the use of HEDIS-defined HRME, although many studies have postulated a beneficial effect of such interventions. OBJECTIVE: To evaluate the effect of pharmacist interventions on use of HRME and Rx-DIS interactions in the outpatient elderly population...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28431058/additional-electrodes-on-the-quartet%C3%A2-lv-lead-provide-more-programmable-pacing-options-than-bipolar-and-tripolar-equivalents
#13
David O'Donnell, Johannes Sperzel, Bernard Thibault, Christopher A Rinaldi, Carlo Pappone, Klaus-Jürgen Gutleben, Christopher Leclercq, Hedi Razavi, Kyungmoo Ryu, Luke C Mcspadden, Avi Fischer, Gery Tomassoni
Aims: The aim of this study was to evaluate any benefits to the number of viable pacing vectors and maximal spatial coverage with quadripolar left ventricular (LV) leads when compared with tripolar and bipolar equivalents in patients receiving cardiac resynchronization therapy (CRT). Methods and Results: A meta-analysis of five previously published clinical trials involving the Quartet™ LV lead (St Jude Medical, St Paul, MN, USA) was performed to evaluate the number of viable pacing vectors defined as capture thresholds ≤2...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28398117/reconstructing-the-times-of-past-and-future-personal-events
#14
Hédi Ben Malek, Fabrice Berna, Arnaud D'Argembeau
Humans have the remarkable ability to mentally travel through past and future times. However, while memory for the times of past events has been much investigated, little is known about how imagined future events are temporally located. Using a think-aloud protocol, we found that the temporal location of past and future events is rarely directly accessed, but instead mostly relies on reconstructive and inferential strategies. References to lifetime periods and factual knowledge (about the self, others, and the world) were most frequently used to determine the temporal location of both past and future events...
April 11, 2017: Memory
https://www.readbyqxmd.com/read/28382934/connecting-myelin-related-and-synaptic-dysfunction-in-schizophrenia-with-snp-rich-gene-expression-hubs
#15
Hedi Hegyi
Combining genome-wide mapping of SNP-rich regions in schizophrenics and gene expression data in all brain compartments across the human life span revealed that genes with promoters most frequently mutated in schizophrenia are expression hubs interacting with far more genes than the rest of the genome. We summed up the differentially methylated "expression neighbors" of genes that fall into one of 108 distinct schizophrenia-associated loci with high number of SNPs. Surprisingly, the number of expression neighbors of the genes in these loci were 35 times higher for the positively correlating genes (32 times higher for the negatively correlating ones) than for the rest of the ~16000 genes...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28381775/fatty-acid-esterification-with-polyols-over-acidic-montmorillonite
#16
Asma Chaari, Soumaya Bouguerra Neji, Mouhamed Hedi Frikha
The production of fatty acid esters from stearic, oleic, and palmitic acids and polyols (ethylene glycol and glycerol) was investigated in this work. A series of montmorillonite-based clays catalysts (KSF, KSF/0, KP10, and K10), having different physicochemical properties, were used as acidic catalysts. The influence of the specific surface area and the acidity of the catalysts on the esterification rate were explored. The best catalytic activities were obtained with KSF catalyst. The optimization of various factors on the reaction was also studied, including catalyst concentration, reaction temperature and molar ratio (polyol /fatty acid)...
April 4, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28359094/birth-weight-in-different-etiologies-of-disorders-of-sex-development
#17
Sukran Poyrazoglu, Feyza Darendeliler, S Faisal Ahmed, Ieuan Hughes, Jillian Bryce, Jipu Jiang, Martina Rodie, Olaf Hiort, Sabine E Hannema, Silvano Bertelloni, Lidka Lisa, Tulay Guran, Martine Cools, An Desloovere, Hedi L Claahsen-van der Grinten, Anna Nordenstrom, Paul-Martin Holterhus, Birgit Kohler, Marek Niedziela, Nils Krone
Context: It is well established that boys are heavier than girls at birth. Although the cause of birth weight (BW) difference is unknown, it has been proposed that it could be generated from prenatal androgen action. Objective: The aim of the current study was to determine the BW of children with disorders of sex development (DSD) of different etiologies and to evaluate the effects of androgen action on BW. Methods: Data regarding diagnosis, BW, gestational age, karyotype, and concomitant conditions were collected from the International Disorders of Sex Development (I-DSD) Registry (www...
March 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28358905/violent-relationships-at-the-social-ecological-level-a-multi-mediation-model-to-predict-adolescent-victimization-by-peers-bullying-and-depression-in-early-and-late-adolescence
#18
Xavier Oriol, Rafael Miranda, Alberto Amutio, Hedy C Acosta, Michelle C Mendoza, Javier Torres-Vallejos
BACKGROUND: From the social-ecological perspective, exposure to violence at the different developmental levels is fundamental to explain the dynamics of violence and victimization in educational centers. The following study aims at analyzing how these relationships are produced in the Peruvian context, where structural violence situations exist. METHODS: A multi-mediation structural model with 21,416 Peruvian adolescents (M = 13.69; SD = 0.71) was conducted to determine the influence of violence in the school environment on violence perceived within school and violence exercised by teachers...
2017: PloS One
https://www.readbyqxmd.com/read/28358156/selective-synthesis-of-mono-and-bis-butenolide-%C3%AE-aminomethyl-adducts
#19
Arbia Talbi, Aïcha Arfaoui, Talia Bsaibess, Mohamed Lotfi Efrit, Anne Gaucher, Damien Prim, Hédi M Rabet
The selective installation of α-methylamine residues at the butenolide core is described using α-bromomethylene-γ-butenolide and primary as well as secondary amines in methanol at 0 °C. The preparation of mono- and bis-butenolide α-adducts is described. Bis-γ-butenolide adducts as well as mono α-aminomethyl-γ-butenolides can be selectively obtained depending on the nature of the reacting primary amine. In contrast, the use of secondary amines allows two different pathways leading either to the expected amino derivatives or to the formation of a C-O bond...
April 11, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28327771/the-roles-of-surface-chemistry-dissolution-rate-and-delivered-dose-in-the-cytotoxicity-of-copper-nanoparticles
#20
Miao Shi, Karen L de Mesy Bentley, Goutam Palui, Hedi Mattoussi, Alison Elder, Hong Yang
The understanding of nanoparticle (NP) cytotoxicity is challenging because of incomplete information about physicochemical changes particles undergo once they come into contact with biological fluids. It is therefore essential to characterize changes in NP properties to better understand their biological fate and effects in mammalian cells. In this paper, we present a study on the effect of particle surface oxidation and dissolution rates of Cu NPs. Particle dissolution, cell-associated Cu doses, and oxidative stress responses in A549 luciferase reporter cells were examined for Cu NPs modified with mercaptocarboxylic acids with different carbon chain lengths and a thiotic acid appended-PEG ligand (TA)...
April 6, 2017: Nanoscale
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