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Andrew J Benjamin, Mary M Buschmann, Shuang Qin Zhang, Kristen Wroblewski, Hedy L Kindler, Kevin K Roggin, William Dale
OBJECTIVE: Sarcopenia is associated with poor outcomes in patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC). However, few studies have assessed changes in sarcopenia during multimodality therapy or its effect on overall survival (OS). METHODS: Computed tomography (CT) total psoas area index (TPAI) and weighted average Hounsfield units (HU) were measured at each treatment interval in patients with resectable PDAC. Four cohorts were compared: 1...
March 10, 2018: Journal of Geriatric Oncology
Khadija Sellami, Meriem Amouri, Sana Kmiha, Emna Bahloul, Hajer Aloulou, Lamia Sfaihi, R Guirat, Madiha Mseddi, T Kamoun, Mongia Hachicha, Hamida Turki
Background: Bacillus Calmette-Guérin (BCG) vaccine is a widely used vaccine. Management of local BCG complications differs between clinicians, and the optimal approach remains unclear. Aims: We aim to describe the epidemiological, clinical and therapeutic aspects of the BCG vaccine side effects in Sfax. Patients and Methods: This was a retrospective study of all the cases of BCG vaccine adverse reactions recorded in the Dermatology and Paediatrics Departments of Hedi Chaker University Hospital of Sfax over a period of 10 years (2005-2015)...
January 2018: Indian Journal of Dermatology
Hedy L Kindler, Nofisat Ismaila, Raffit Hassan
No abstract text is available yet for this article.
March 8, 2018: Journal of Oncology Practice
Sarika Rane Parasuraman, Sarah Lindstrom Johnson, Dawn Magnusson, Tracy King
BACKGROUND: Health plans are increasingly implementing quality improvement strategies aimed at meeting adolescent clinical quality measures, yet clinics often struggle to meet these measures. This qualitative study was conducted to explore how efforts to meet the National Committee for Quality Assurance (NCQA) Healthcare Effectiveness Data and Information Set (HEDIS) performance measure for adolescent well-care visits were perceived by a multidisciplinary group of stakeholders. METHODS: The research team conducted 26 in-depth, semistructured interviews with participants from three stakeholder groups: clinic staff with direct patient contact, health care institutional leaders, and representatives of a payer organization...
March 2018: Joint Commission Journal on Quality and Patient Safety
Sana Ben Slama, Dorra Ben Ghachem, Amen Dhaoui, Sarra Ben Rejeb, Mohamed Taieb Jomni, Mohamed Hédi Dougui, Khadija Bellil
BACKGROUND: Autoimmune gastritis present a risk of cancer related to atrophy and intestinal metaplasia. Two recent classifications OLGA (Operative Link on Gastritis Assessment) and OLGIM (Operative Link on Gastritic Intestinal Metaplasia assessment) have been proposed to reveal the high progressive risk forms (stages III and IV). AIM: To evaluate the OLGA and OLGIM staging systems in chronic autoimmune gastritis. METHODS: A descriptive single institution study of 30 cases of autoimmune gastritis...
April 2017: La Tunisie Médicale
Henrik Falhammar, Hedi L Claahsen-van der Grinten, Nicole Reisch, Jolanta Slowikowska-Hilczer, Anna Nordenstrom, Robert Roehle, Claire Bouvattier, Baudewijntje P Kreukels, Birgit Koehler
OBJECTIVE: The knowledge about health status in adults with disorder of sex development (DSD) is scarce. DESIGN AND METHODS: A cross-sectional observational study in 14 European tertiary centers recruited 1040 participants (717 females, 311 males, 12 others) with DSD. Mean age was 32.4±13.6 year (range 16-75). The cohort was divided into: Turner (n=301), Klinefelter (n=224), XY-DSD (n=222), XX-DSD (excluding congenital adrenal hyperplasia (CAH) and 46,XX males)(n=21), 46,XX-CAH (n=226), and 45,X/46,XY (n=45)...
February 28, 2018: Endocrine Connections
Temidayo Fadelu, Sui Zhang, Donna Niedzwiecki, Xing Ye, Leonard B Saltz, Robert J Mayer, Rex B Mowat, Renaud Whittom, Alexander Hantel, Al B Benson, Daniel M Atienza, Michael Messino, Hedy L Kindler, Alan Venook, Shuji Ogino, Kimmie Ng, Kana Wu, Walter Willett, Edward Giovannucci, Jeffrey Meyerhardt, Ying Bao, Charles S Fuchs
Purpose Observational studies have reported increased colon cancer recurrence and mortality in patients with states of hyperinsulinemia, including type 2 diabetes, obesity, sedentary lifestyle, and high glycemic load diet. Nut intake has been associated with a lower risk of type 2 diabetes, metabolic syndrome, and insulin resistance. However, the effect of nut intake on colon cancer recurrence and survival is not known. Patients and Methods We conducted a prospective, observational study of 826 eligible patients with stage III colon cancer who reported dietary intake on food frequency questionnaires while enrolled onto a randomized adjuvant chemotherapy trial...
February 28, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Maha Hmissi, Jérôme Harmand, Victor Alcaraz-Gonzalez, Hedi Shayeb
In this paper, an experimental study upon alkalinity and hydrodynamic behavior in an anaerobic up-flow fixed bed reactor for the treatment of tequila vinasses is presented. Measurements of volatile fatty acids, pH, alkalinity and bicarbonate were obtained at three sampling points in the reactor in the axial axis. Then, the spatial distribution of alkalinity is studied and discussed. Moreover, for further control process purposes, a hydrodynamic model based on the use of two interconnected two-steps reduced AM2 type models is proposed and its parameters are identified using experimental data...
February 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Imen Zghal, Amine Souguir, Olfa Fekih, Amel Chebbi, Omar Romdhane, Hedi Bouguila, Leila Nacef
BACKGROUND: Postoperative endophthalmitis is a public health issue due to its bad prognosis; its treatment is both surgical and medical. Classically, surgical treatment was done if visual acuity is limited to light perception only. AIM: To evaluate therapeutic results Of postoperative endophtalmitieS and to Compare therapeutics almost used intravitreal injection of antibiotics versus early vitrectomy. METHODS: It's a retrospective comparative study includIng 120 cases of acute postoperative endophthalmitis hospitalized in a referral ophthalmology department between July 2007 and June 2013...
March 2017: La Tunisie Médicale
Hedi An, Xiaoyan Zeng, Tengfei Niu, Gaiying Li, Jie Yang, Lanlan Zheng, Wei Zhou, Hong Liu, Miaomiao Zhang, Dongya Huang, Jianqi Li
BACKGROUND: Iron deposition within the substantia nigra (SN) has been postulated to play a vital role in Parkinson's disease (PD). The aim of this study was to explore the inherent link of PD patients between their substantia nigra iron accumulation and clinical status using quantitative susceptibility mapping (QSM) which is now considered to be the only quantitative imaging technique of brain iron deposition. METHODS: 44 PD patients and 31 age- and gender-matched healthy controls underwent quantitative susceptibility mapping (QSM) were recruited in this study...
March 15, 2018: Journal of the Neurological Sciences
Christopher Piorkowski, Arash Arya, Craig D Markovitz, Hedi Razavi, Chunlan Jiang, Stuart Rosenberg, Ole-A Breithardt, Sascha Rolf, Silke John, Jedrzej Kosiuk, Yan Huo, Michael Döring, Sergio Richter, Kyungmoo Ryu, Thomas Gaspar, Frits W Prinzen, Gerhard Hindricks, Philipp Sommer
PURPOSE: Cardiac disease frequently has a degenerative effect on cardiac pump function and regional myocardial contraction. Therefore, an accurate assessment of regional wall motion is a measure of the extent and severity of the disease. We sought to further validate an intra-operative, sensor-based technology for measuring wall motion and strain by characterizing left ventricular (LV) mechanical and electrical activation patterns in patients with normal (NSF) and impaired systolic function (ISF)...
January 31, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Amanda W Benedict, Michele M Spence, John L Sie, Helen A Chin, Chi D Ngo, Jennifer F Salmingo, Andrew T Vidaurreta, Nazia Rashid
BACKGROUND: Pharmacists have important roles in managing the therapy of patients with type 2 diabetes and improving patient care. Pharmacists titrate medications; reinforce patient education; and address care gaps, such as medication adherence, vaccinations, and overdue health screenings. Through these efforts and more, pharmacists help to improve patient care and achieve Healthcare Effectiveness Data and Information Set (HEDIS) measures. Thus, it is important to demonstrate improved health outcomes through pharmacist contributions to diabetes management, which can then provide an opportunity to expand the role of clinical pharmacists in other medical centers and practice settings within an integrated health care system...
February 2018: Journal of Managed Care & Specialty Pharmacy
Quentin Schull, Jean-Patrice Robin, F Stephen Dobson, Hédi Saadaoui, Vincent A Viblanc, Pierre Bize
Sexual selection and social selection are two important theories proposed for explaining the evolution of colorful ornamental traits in animals. Understanding signal honesty requires studying how environmental and physiological factors during development influence the showy nature of sexual and social ornaments. We experimentally manipulated physiological stress and immunity status during the molt in adult king penguins (Aptenodytes patagonicus), and studied the consequences of our treatments on colourful ornaments (yellow-orange and UV beak spots and yellow-orange auricular feather patches) known to be used in sexual and social contexts in this species...
January 2018: Ecology and Evolution
Dinesh Mishra, Sisi Wang, Serge Michel, Goutam Palui, Naiqian Zhan, Woody Perng, Zhicheng Jin, Hedi Mattoussi
We have combined optical absorption with the Ellman's test to identify the parameters that affect the transformation of the 5-membered dithiolanes to thiols in lipoic acid (LA) and its derivatives during UV-irradiation. We found that the nature and polarity of the solvent, the structure of the ligands, acidity of the medium and oxygen can drastically affect the amount of photogenerated thiols. These findings are highly relevant to the understanding of the photochemical transformation of this biologically relevant compound, and would benefit the increasing use of LA-based ligands for the surface functionalization of various nanomaterials...
January 25, 2018: Physical Chemistry Chemical Physics: PCCP
Kahena Bouzid, Habib Ben Ahmed, Houssem Boussaid, Mourad Kamoun, Sirine Lahiani, Jaouida Abdelmoula, Wijdene Ouechtati, Hédi Baccar
No abstract text is available yet for this article.
August 2017: Atherosclerosis
Erin L Van Blarigan, Charles S Fuchs, Donna Niedzwiecki, Xing Ye, Sui Zhang, Mingyang Song, Leonard Saltz, Robert J Mayer, Rex B Mowat, Renaud Whittom, Alexander Hantel, Al Benson, Daniel Atienza, Michael Messino, Hedy Kindler, Alan Venook, Shuji Ogino, Edward L Giovannucci, Jeffrey A Meyerhardt
BACKGROUND: Marine ω-3 polyunsaturated fatty acids (PUFAs), primarily found in dark fish, may prevent colorectal cancer progression, in part through inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2). However, data in humans are limited. METHODS: We examined marine ω-3 PUFAs and fish intake and survival among 1,011 colon cancer patients enrolled in CALGB 89803 between 1999 to 2001 and followed through 2009. Diet was assessed during and 6 months after chemotherapy...
January 22, 2018: Cancer Epidemiology, Biomarkers & Prevention
Katherine E Powers, Gideon Yaffe, Catherine A Hartley, Juliet Y Davidow, Hedy Kober, Leah H Somerville
Adolescents routinely take risks that impact the well-being of the friends they are with. However, it remains unclear when and how consequences for friends factor into decisions to take risks. Here we used an economic decision-making task to test whether risky choices are guided by the positive and negative consequences they promise for peers. Across a large developmental sample of participants ages 12-25, we show that risky decision computations increasingly assimilate friends' outcomes throughout adolescence into early adulthood in an asymmetric manner that overemphasizes protecting friends from incurring loss...
January 22, 2018: Journal of Experimental Psychology. General
Hedy L Kindler, Nofisat Ismaila, Samuel G Armato, Raphael Bueno, Mary Hesdorffer, Thierry Jahan, Clyde Michael Jones, Markku Miettinen, Harvey Pass, Andreas Rimner, Valerie Rusch, Daniel Sterman, Anish Thomas, Raffit Hassan
Purpose To provide evidence-based recommendations to practicing physicians and others on the management of malignant pleural mesothelioma. Methods ASCO convened an Expert Panel of medical oncology, thoracic surgery, radiation oncology, pulmonary, pathology, imaging, and advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 1990 through 2017. Outcomes of interest included survival, disease-free or recurrence-free survival, and quality of life...
January 18, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Manon Engels, Katharina Gehrmann, Henrik Falhammar, Emma A Webb, Anna Nordenstrom, Fred Sweep, Paul N Span, Antonius Eduard van Herwaarden, Julia Rohayem, Annette Richter-Unruh, Claire Bouvattier, Birgit Koehler, Barbara B Kortmann, Wiebke Arlt, Nel Roeleveld, Nicole Reisch, Nike Stikkelbroeck, Hedi L Claahsen-van der Grinten
CONTEXT: Current knowledge on gonadal function in Congenital Adrenal Hyperplasia (CAH) is mostly limited to single center/country studies enrolling small patient numbers. Overall data indicate that gonadal function can be compromised in men with CAH. OBJECTIVE: To determine gonadal function in men with CAH within the European "dsd-LIFE" cohort. DESIGN: Cross-sectional clinical outcome study, including retrospective data from medical records...
January 16, 2018: European Journal of Endocrinology
Eileen M O'Reilly, Jonathan W Lee, Maeve A Lowery, Marinela Capanu, Zsofia K Stadler, Malcolm J Moore, Neesha Dhani, Hedy L Kindler, Hayley Estrella, Hannah Maynard, Talia Golan, Amiel Segal, Erin E Salo-Mullen, Kenneth H Yu, Andrew S Epstein, Michal Segal, Robin Brenner, Richard K Do, Alice P Chen, Laura H Tang, David P Kelsen
BACKGROUND: A phase 1 trial was used to evaluate a combination of cisplatin, gemcitabine, and escalating doses of veliparib in patients with untreated advanced pancreatic ductal adenocarcinoma (PDAC) in 2 cohorts: a germline BRCA1/2-mutated (BRCA+) cohort and a wild-type BRCA (BRCA-) cohort. The aims were to determine the safety, dose-limiting toxicities (DLTs), maximum tolerated dose, and recommended phase 2 dose (RP2D) of veliparib combined with cisplatin and gemcitabine and to assess the antitumor efficacy (Response Evaluation Criteria in Solid Tumors, version 1...
January 16, 2018: Cancer
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