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https://www.readbyqxmd.com/read/28231678/-application-of-disease-risk-score-in-pharmacoepidemiologic-studies
#1
H Y Zhao, S Y Zhan
Disease risk score (DRS) can be used to adjust the confounding effects on data with high dimensions and can reduce related bias through balancing the risk or probability, regarding the development of some specific diseases, between the two compared groups. The DRS approach thus can be applied to studies of pharmacoepidemiology when administrative medical database is used for data analysis. Although DRS functions are similarly to the propensity scores (PS) under many situations, even with some advantages over PS or conventional analytical methods in some special exposure settings, the usage of DRS is far limited than the PS method...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28231601/early-age-at-first-sexual-intercourse-is-associated-with-higher-prevalence-of-high-grade-squamous-intraepithelial-lesions-hsil
#2
José Cândido Caldeira Xavier-Júnior, Rozany Mucha Dufloth, Diama Bhadra Vale, Marcelo Tavares de Lima, Luiz Carlos Zeferino
Objective To evaluate the association of age at first sexual intercourse with the results of the cervicovaginal cytology. Study Design Observational analytical study about the prevalence of altered cervicovaginal cytology results in women aged between 18 and 34 years from a densely populated area in Brazil, during 10 years. The patients were stratified into 2 categories according to their age at first sexual intercourse (13-16 years and 17-24 years). Results From the total of 2,505,154 exams, 898,921 tests were in accordance with the inclusion criteria...
February 23, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28231554/design-of-elution-strategy-for-simultaneous-detection-of-chloramphenicol-and-gentamicin-in-complex-samples-using-surface-plasmon-resonance
#3
Yinqiang Xia, Rongxin Su, Renliang Huang, Li Ding, Libing Wang, Wei Qi, Zhimin He
For the analysis of massive samples containing multiple analytes, the enhancement of detection efficiency is crucial. In this study, a facile method was developed for sequential detection of chloramphenicol (CAP) and gentamicin (GEN) in complex samples, e.g. milk, using a surface plasmon resonance (SPR)-based biosensor. Based on the immune inhibition format, two conjugates of antigen and bovine serum albumin (BSA)-denoted as CAP-BSA and GEN-BSA-were grafted on the same channel of the SPR sensor chip. Two standard curves for CAP and GEN were separately obtained by first mixing a single antibody with different concentrations of the relevant antigen...
February 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28231552/progress-and-challenges-in-electrochemiluminescent-aptasensors
#4
REVIEW
Kateryna Muzyka, Muhammad Saqib, Zhongyuan Liu, Wei Zhang, Guobao Xu
The importance of developing new diagnostic and detection technologies for the growing number of sensing challenges is rising each year. Here, we present a comprehensive and concise review on electrochemiluminescent (ECL) aptasensors by putting special emphasis on its characteristic features, advances, challenges, and applications of ECL based aptasensors. ECL is an ideal tool for constructing such sensors because of its inherent characteristics and can be easily integrated into aptamer based sensing platforms...
January 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28231533/synthesis-characterization-and-dna-binding-cleavage-protein-binding-and-cytotoxicity-studies-of-co-ii-ni-ii-cu-ii-and-zn-ii-complexes-of-aminonaphthoquinone
#5
A Kosiha, C Parthiban, Kuppanagounder P Elango
The Co(II), Ni(II), Cu(II) and Zn(II) complexes of an aminonaphthoquinone ligand (L) have been prepared and characterized using analytical and spectral techniques. The structures of L and its Zn(II) complex are confirmed by single crystal X-ray diffraction study. The results indicate that Co(II), Ni(II) and Zn(II) complexes possess tetrahedral geometry while Cu(II) complex exhibits square planar structure. The interaction of L and its complexes with CT-DNA reveal that they could interact with CT-DNA through intercalation...
February 16, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28231527/rapid-discrimination-and-determination-of-antibiotics-drugs-in-plastic-syringes-using-near-infrared-spectroscopy-with-chemometric-analysis-application-to-amoxicillin-and-penicillin
#6
Laetitia Minh Mai Lê, Luc Eveleigh, Ikram Hasnaoui, Patrice Prognon, Arlette Baillet-Guffroy, Eric Caudron
The aim of this study was to investigate near infrared spectroscopy (NIRS) combined to chemometric analysis to discriminate and quantify three antibiotics by direct measurement in plastic syringes.Solutions of benzylpenicillin (PENI), amoxicillin (AMOX) and amoxicillin/clavulanic acid (AMOX/CLAV) were analyzed at therapeutic concentrations in glass vials and plastic syringes with NIR spectrometer by direct measurement. Chemometric analysis using partial least squares regression and discriminative analysis was conducted to develop qualitative and quantitative calibration models...
February 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28231324/a-framework-for-analyzing-contagion-in-assortative-banking-networks
#7
Thomas R Hurd, James P Gleeson, Sergey Melnik
We introduce a probabilistic framework that represents stylized banking networks with the aim of predicting the size of contagion events. Most previous work on random financial networks assumes independent connections between banks, whereas our framework explicitly allows for (dis)assortative edge probabilities (i.e., a tendency for small banks to link to large banks). We analyze default cascades triggered by shocking the network and find that the cascade can be understood as an explicit iterated mapping on a set of edge probabilities that converges to a fixed point...
2017: PloS One
https://www.readbyqxmd.com/read/28231289/rehr-an-r-package-for-manipulating-and-analysing-electronic-health-record-data
#8
David A Springate, Rosa Parisi, Ivan Olier, David Reeves, Evangelos Kontopantelis
Research with structured Electronic Health Records (EHRs) is expanding as data becomes more accessible; analytic methods advance; and the scientific validity of such studies is increasingly accepted. However, data science methodology to enable the rapid searching/extraction, cleaning and analysis of these large, often complex, datasets is less well developed. In addition, commonly used software is inadequate, resulting in bottlenecks in research workflows and in obstacles to increased transparency and reproducibility of the research...
2017: PloS One
https://www.readbyqxmd.com/read/28231060/improving-quality-in-the-preanalytical-phase-through-innovation-on-behalf-of-the-european-federation-for-clinical-chemistry-and-laboratory-medicine-eflm-working-group-for-preanalytical-phase-wg-pre
#9
Giuseppe Lippi, Geoffrey S Baird, Giuseppe Banfi, Karin Bölenius, Janne Cadamuro, Stephen Church, Michael P Cornes, Anna Dacey, Antoine Guillon, Georg Hoffmann, Mads Nybo, Lakdasa Devananda Premawardhana, María Salinas, Sverre Sandberg, Robbert Slingerland, Ana Stankovic, Sylte Marit Sverresdotter, Pieter Vermeersch, Ana-Maria Simundic
It is now undeniable that laboratory testing is vital for the diagnosis, prognostication and therapeutic monitoring of human disease. Despite the many advances made for achieving a high degree of quality and safety in the analytical part of diagnostic testing, many hurdles in the total testing process remain, especially in the preanalytical phase ranging from test ordering to obtaining and managing the biological specimens. The Working Group for the Preanalytical Phase (WG-PRE) of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) has planned many activities aimed at mitigating the vulnerability of the preanalytical phase, including the organization of three European meetings in the past 7 years...
February 23, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28231032/effects-of-live-trapping-and-isoflurane-anesthesia-on-free-ranging-american-martens-martes-americana
#10
Maria C Spriggs, Lisa I Muller, Paul Keenlance, Robert L Sanders, Jill C Witt, Debra L Miller
Seventy-two free-ranging American martens ( Martes americana ) in Michigan were immobilized using isoflurane from 2011 to 2015. In total, 129 anesthetic procedures were performed with no mortalities. Hypothermia and hyperthermia were the most common anesthetic complications, and the mean rectal temperatures were significantly higher during summer than in winter. Dental abnormalities were common; the majority of abnormal findings were broken or discolored teeth attributed to previous dental trauma and were not trap-induced...
February 23, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28230979/simple-expendable-3d-printed-microfluidic-systems-for-sample-preparation-of-petroleum
#11
Erica Megumi Kataoka, Rui Cesar Murer, Jandyson Machado Santos, Rogerio Mesquita de Carvalho, Marcos Nogueira Eberlin, Fabio Augusto, Ronei Jesus Poppi, Angelo Luiz Gobbi, Leandro Wang Hantao
In this study, we introduce a simple protocol to manufacture disposable, 3D-printed microfluidic systems for sample preparation of petroleum. Such platform is produced with a consumer-grade 3D-printer, using fused deposition modeling. Successful incorporation of solid-phase extraction (SPE) to microchip was ensured by facile 3D element integration using proposed approach. This 3D-printed μSPE device was applied to challenging matrices in oil & gas industry, such as crude oil and oil-brine emulsions. Case studies investigated important limitations of non-silicon and non-glass microchips, namely, resistance to nonpolar solvents and conservation of sample integrity...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28230966/increasing-peak-capacity-in-non-targeted-omics-applications-by-combining-full-scan-field-asymmetric-waveform-ion-mobility-spectrometry-with-liquid-chromatography-mass-spectrometry
#12
Kayleigh L Arthur, Matthew A Turner, James C Reynolds, Colin S Creaser
Full scan field asymmetric waveform ion mobility spectrometry (FAIMS) combined with liquid chromatography and mass spectrometry (LC-FAIMS-MS) is shown to enhance peak capacity for omics applications. A miniaturized FAIMS device capable of rapid compensation field scanning has been incorporated into an ultra-high performance liquid chromatography (UHPLC) and time-of-flight (TOF) mass spectrometry analysis, allowing the acquisition of full scan FAIMS and MS nested data sets within the timescale of a UHPLC peak...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28230758/quantitative-determination-of-stilbenoids-and-dihydroisocoumarins-in-shorea-roxburghii-and-evaluation-of-their-hepatoprotective-activity
#13
Kiyofumi Ninomiya, Saowanee Chaipech, Yusuke Kunikata, Ryohei Yagi, Yutana Pongpiriyadacha, Osamu Muraoka, Toshio Morikawa
A simultaneous quantitative analytical method for 13 stilbenoids including (-)-hopeaphenol (1), (+)-isohopeaphenol (2), hemsleyanol D (3), (-)-ampelopsin H (4), vaticanols A (5), E (6), and G (7), (+)-α-viniferin (8), pauciflorol A (9), hopeafuran (10), (-)-balanocarpol (11), (-)-ampelopsin A (12), and trans-resveratrol 10-C-β-d-glucopyranoside (13), and two dihydroisocoumarins, phayomphenols A₁ (14) and A₂ (15) in the extract of Shorea roxburghii (dipterocarpaceae) was developed. According to the established protocol, distributions of these 15 polyphenols (1-15) in the bark and wood parts of S...
February 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28230712/updating-evidence-for-using-hypothermia-in-pediatric-severe-traumatic-brain-injury-conventional-and-bayesian-meta-analytic-perspectives
#14
Robert C Tasker, Frederick W Vonberg, Elizabeth D Ulano, Alireza Akhondi-Asl
OBJECTIVE: To evaluate clinical trials of hypothermia management on outcome in pediatric patients with severe traumatic brain injury using conventional and Bayesian meta-analyses. DATA SOURCES: Screening of PubMed and other databases to identify randomized controlled trials of hypothermia for pediatric severe traumatic brain injury published before September 2016. STUDY SELECTION: Four investigators assessed and reviewed randomized controlled trial data...
February 20, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28230486/analytical-microscopy-methods-compared-epxma-xpxma-and-sims
#15
Peter Ingram, Ann LeFurgey
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28230478/analytical-imaging-of-the-mitochondrion-probes-of-form-and-function-revisited
#16
Ann LeFurgey, Peter Ingram
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28230414/the-effect-of-cognitive-behavioral-therapy-as-an-antidepressive-treatment-is-falling-reply-to-lj%C3%A3-tsson-et-al-2017-and-cristea-et-al-2017
#17
Oddgeir Friborg, Tom J Johnsen
This article critically reassesses the nonlinear reanalysis by Ljótsson, Hedman, Mattsson, and Andersson (2017) and reviews Cristea et al.'s (2017) extension of our original meta-analysis (Johnsen & Friborg, 2015) reporting a decline in the effects of cognitive-behavioral therapy (CBT) for treating unipolar depression. Ljótsson et al. fitted a piecewise meta-regression model to the data, indicating a halt in the decline from the year 1995 onward, hence concluding that CBT is not gradually losing its efficacy...
March 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28230412/the-effects-of-cognitive-behavioral-therapy-for-depression-are-not-falling-a-re-analysis-of-johnsen-and-friborg-2015
#18
Brjánn Ljótsson, Erik Hedman, Simon Mattsson, Erik Andersson
Cognitive-behavioral therapy (CBT) has a solid evidence base as an effective treatment for depression. However, a recent meta-analysis (Johnsen & Friborg, 2015) including 70 studies, showed that the effect sizes of CBT for depression have been falling between 1977 and 2014. A possible important limitation in the Johnsen and Friborg (2015) study was that they did not investigate a leveling off in the decline over time of the effectiveness of CBT for depression. We therefore reanalyzed the data reported by Johnsen and Friborg (2015) using meta-analytic regression models that allowed for a curvilinear effect of publication year and also modeled separate estimates of the decline of treatment effect before and after 1995...
March 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28230388/familial-ethnic-socialization-gender-role-attitudes-and-ethnic-identity-development-in-mexican-origin-early-adolescents
#19
Delida Sanchez, Tiffany A Whittaker, Emma Hamilton, Sarah Arango
OBJECTIVES: This study examined the relations between familial ethnic socialization and ethnic identity development in 438 Mexican-origin (n = 242 boys and n = 196 girls) preadolescents. In addition, machismo and marianismo gender role attitudes were examined as potential mediators in this link. METHOD: Confirmatory factor analyses (CFA) of the Familial Ethnic Socialization Scale (FES), Machismo Measure (MM), Marianismo Beliefs Scale (MBS), and the Ethnic Identity Brief Scale (EISB) were conducted to test the factor structure with a preadolescent Mexican-origin sample...
February 23, 2017: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/28230351/fabrication-and-demonstration-of-mercury-disc-well-probes-for-stripping-based-cyclic-voltammetry-scanning-electrochemical-microscopy
#20
Zachary J Barton, Joaquín Rodríguez-López
Scanning electrochemical microscopy (SECM) is a rising technique for the study of energy storage materials. Hg-based probes allow the extension of SECM investigations to ionic processes, but the risk of irreversible Hg amalgam saturation limits their operation to rapid timescales and dilute analyte solutions. Here, we report a novel fabrication protocol for Hg disc-well ultramicroelectrodes (UMEs), which retain access to stripping information but are less susceptible to amalgam saturation than traditional Hg sphere-caps or thin-films...
February 23, 2017: Analytical Chemistry
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