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https://www.readbyqxmd.com/read/28635330/multiple-functions-of-insulin-degrading-enzyme-a-metabolic-crosslight
#1
Grazia R Tundo, Diego Sbardella, Chiara Ciaccio, Giuseppe Grasso, Magda Gioia, Andrea Coletta, Fabio Polticelli, Donato Di Pierro, Danilo Milardi, Peter Van Endert, Stefano Marini, Massimo Coletta
Insulin-degrading enzyme (IDE) is a ubiquitous zinc peptidase of the inverzincin family, which has been initially discovered as the enzyme responsible for insulin catabolism; therefore, its involvement in the onset of diabetes has been largely investigated. However, further studies on IDE unraveled its ability to degrade several other polypeptides, such as β-amyloid, amylin, and glucagon, envisaging the possible implication of IDE dys-regulation in the "aggregopathies" and, in particular, in neurodegenerative diseases...
June 21, 2017: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28634414/monitoring-and-analysis-of-coastal-reclamation-from-1995-2015-in-tianjin-binhai-new-area-china
#2
Wengang Chen, Dongchuan Wang, Yong Huang, Liding Chen, Lihui Zhang, Xiangwang Wei, Mengqin Sang, Feicui Wang, Jinya Liu, Bingxu Hu
Increasing coastal reclamation activities have been undertaken to solve the conflict between people and land resources, creating significant challenges for coordinating coastal reclamation, economic development and environmental protection. This paper analyzes the effects of coast reclamation on Gross Domestic Product growth and the quality of inshore seawater in the Tianjin Binhai New Area. Remote sensing and a Geographic Information System were used to extract the information of coastal reclamation. The correlation between the area of coastal reclamation, GDP growth and the quality of inshore seawater was analyzed and a decoupling elasticity model was used to explore trends in the relationship between economic development and coastal reclamation...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28620835/twenty-years-since-the-discovery-of-the-parkin-gene
#3
REVIEW
Nobutaka Hattori, Yoshikuni Mizuno
Nearly 20 years have passed since we identified the causative gene for a familial Parkinson's disease, parkin (now known as PARK2), in 1998. PARK2 is the most common gene responsible for young-onset Parkinson's disease. It codes for the protein Parkin RBR E3 ubiquitin-protein ligase (PARK2), which directly links to the ubiquitin-proteasome as a ubiquitin ligase. PARK2 is involved in mitophagy, which is a type of autophagy, in collaboration with PTEN-induced putative kinase 1 (PINK1). The PINK1 gene (previously known as PARK6) is also a causative gene for young-onset Parkinson's disease...
June 15, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28620758/transcriptome-analysis-of-drought-responsive-genes-regulated-by-hydrogen-sulfide-in-wheat-triticum-aestivum-l-leaves
#4
Hua Li, Min Li, Xingliang Wei, Xia Zhang, Ruili Xue, Yidan Zhao, Huijie Zhao
Drought is an environmental factor that deeply impacts wheat yield and quality. Hydrogen sulfide (H2S) is a known regulator of drought resistance in plants. To preliminarily elucidate the regulatory mechanisms of H2S on drought tolerance, the effects of H2S on drought-responsive genes were investigated by transcriptome analysis. As a result, a total of 7552 transcripts not only responded to drought stress but also exhibited differential expression relative to the polyethylene glycol (PEG) treatment (P) and the NaHS pretreatment with PEG treatment (SP)...
June 15, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28614750/2d-cos-of-in-situ-%C3%AE-raman-and-in-situ-ir-spectra-for-structure-evolution-characterisation-of-nep-deposited-cobalt-oxide-catalyst-during-n-nonane-combustion
#5
Damian K Chlebda, Przemysław J Jodłowski, Roman J Jędrzejczyk, Joanna Łojewska
New catalytic systems are still in development to meet the challenge of regulations concerning the emission of volatile organic compounds (VOCs). This is because such compounds have a significant impact on air quality and some of them are toxic to the environment and human beings. The catalytic combustion process of VOCs over non-noble metal catalysts is of great interest to researchers. The high conversion parameters and cost effective preparation makes them a valuable alternative to monoliths and noble metal catalysts...
June 6, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28611236/quantification-of-circulating-gdf-11-and-%C3%AE-2-mg-in-aged-patients-with-age-related-impairment-in-cognitive-function
#6
Rungong Yang, Shuhong Fu, Liang Zhao, Bei Zhen, Ling Ye, Xiaolu Niu, Xiaoxia Li, Pumin Zhang, Jie Bai
GDF-11 has been implicated in reverse effects of aging on the central nervous system of humans. β2-MG has been reported to negatively regulate cognitive. However, there is a lot of controversy about the role of GDF-11 and β2-MG in ageing and cognitive regulation. Objective: To examine the involvement of GDF-11 and β2-MG in the aging process and cognitive dysfunction. Methods: A total of 51 healthy subjects and 41 elderly patients with different degrees of age-related cognitive impairment participated in the study...
June 13, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28606089/alterations-of-anti-inflammatory-lipids-in-plasma-from-women-with-chronic-widespread-pain-a-case-control-study
#7
Niclas Stensson, Bijar Ghafouri, Björn Gerdle, Nazdar Ghafouri
BACKGROUND: Chronic widespread pain conditions (CWP) such as the pain associated with fibromyalgia syndrome (FMS) are significant health problems with unclear aetiology. Although CWP and FMS can alter both central and peripheral pain mechanisms, there are no validated markers for such alterations. Pro- and anti-inflammatory components of the immune system such as cytokines and endogenous lipid mediators could serve as systemic markers of alterations in chronic pain. Lipid mediators associated with anti-inflammatory qualities - e...
June 12, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28603082/regulation-and-physiological-role-of-silicon-in-alleviating-drought-stress-of-mango
#8
Mohamed Naser Helaly, Hanan El-Hoseiny, Nabil Ibrahim El-Sheery, Anshu Rastogi, Hazem M Kalaji
Improvement of drought stress of mango plants requires intensive research that focuses on physiological processes. In three successive seasons (2014, 2015and 2016) field experiments with four different strains of mango were subjected to two water regimes. The growth and physiological parameters of possible relevance for drought stress tolerances in mango were investigated. Yield and its components were also evaluated. The data showed that all growth and physiological parameters were increased under K2SiO3 (Si) supplement and were followed by the interaction treatment (Si treatment and its combination with drought stress) compared to that of the controlled condition...
June 3, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28602010/closed-loop-regulation-of-arterial-pressure-after-acute-brain-death
#9
Kristian Soltesz, Trygve Sjöberg, Tomas Jansson, Rolf Johansson, Anders Robertsson, Audrius Paskevicius, Quiming Liao, Guangqi Qin, Stig Steen
The purpose of this concept study was to investigate the possibility of automatic mean arterial pressure (MAP) regulation in a porcine heart-beating brain death (BD) model. Hemodynamic stability of BD donors is necessary for maintaining acceptable quality of donated organs for transplantation. Manual stabilization is challenging, due to the lack of vasomotor function in BD donors. Closed-loop stabilization therefore has the potential of increasing availability of acceptable donor organs, and serves to indicate feasibility within less demanding patient groups...
June 10, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28601340/pilot-scale-evaluation-of-semi-passive-treatment-technologies-for-the-treatment-of-septage-under-temperate-climate-conditions
#10
Christine Gan, Pascale Champagne, Geof Hall
Population growth in rural Canada has resulted in an increase in municipal septage generation, which could overload existing treatment facilities that rely on biological treatment approaches. To address concerns associated with potential shock loading of these systems, three semi-passive wastewater treatment technologies were compared at the pilot-scale to identify a suitable approach to augment the capacity of an existing wastewater stabilization pond facility in rural Ontario. Two of these technologies, the BioDome and BioCord systems, were commercially available systems that make use of biofilm technology to improve treatment performance and enhance the robustness to temperature and hydraulic loading fluctuations...
June 7, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28600180/de-novo-transcriptome-sequencing-and-comparative-analysis-of-midgut-tissues-of-four-non-model-insects-pertaining-to-hemiptera-coleoptera-diptera-and-lepidoptera
#11
Rajesh K Gazara, Christiane Cardoso, Daniel Bellieny-Rabelo, Clélia Ferreira, Walter R Terra, Thiago M Venancio
Despite the great morphological diversity of insects, there is a regularity in their digestive functions, which is apparently related to their physiology. In the present work we report the de novo midgut transcriptomes of four non-model insects from four distinct orders: Spodoptera frugiperda (Lepidoptera), Musca domestica (Diptera), Tenebrio molitor (Coleoptera) and Dysdercus peruvianus (Hemiptera). We employed a computational strategy to merge assemblies obtained with two different algorithms, which substantially increased the quality of the final transcriptomes...
June 6, 2017: Gene
https://www.readbyqxmd.com/read/28597094/-autopsy-in-oncology-treatment-validation-in-cancer-centers-and-clinical-cancer-registries
#12
REVIEW
F Hofstädter
The legal recognition of autopsy as a tool of quality assurance will strengthen its importance especially in the care of cancer patients. However, this confidence is relativized by the consideration of the assessment of the autopsy in various effective nonlegislative regulations. This consideration shows that in contrast to earlier years autopsy does not play a major role in the most important programs for the certification of cancer centers or for clinical cancer registration. If clinical autopsy is to play a more important role in the future, then in addition to improving and standardizing its quality the implementation into these systems of quality management is indispensable...
June 9, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28596640/working-with-layers-the-governance-and-regulation-of-healthcare-quality-in-an-institutionally-layered-system
#13
Hester M van de Bovenkamp, Annemiek Stoopendaal, Roland Bal
Institutional arrangements used to steer public policies have increasingly become layered. Inspired by the literature on institutional layering and institutional work, this paper aims to make a contribution to our understanding of institutional layering. We do so by studying an interesting case of layering: the Dutch hospital sector. We focus on the actors responsible for the internal governance (Board of Directors and Supervisory Boards) and the external regulation (the Healthcare Inspectorate) of hospitals...
January 2017: Public Policy Adm
https://www.readbyqxmd.com/read/28595671/from-the-sain-lim-system-to-the-sens-algorithm-a-review-of-a-french-approach-of-nutrient-profiling
#14
Marion Tharrey, Matthieu Maillot, Véronique Azaïs-Braesco, Nicole Darmon
Nutrient profiling aims to classify or rank foods according to their nutritional composition to assist policies aimed at improving the nutritional quality of foods and diets. The present paper reviews a French approach of nutrient profiling by describing the SAIN,LIM system and its evolution from its early draft to the simplified nutrition labelling system (SENS) algorithm. Considered in 2010 by WHO as the 'French model' of nutrient profiling, SAIN,LIM classifies foods into four classes based on two scores: a nutrient density score (NDS) called SAIN and a score of nutrients to limit called LIM, and one threshold on each score...
June 9, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28590436/volatile-organic-compounds-in-anatomical-pathology-wards-comparative-and-qualitative-assessment-of-indoor-airborne-pollution
#15
Massimo Cipolla, Alberto Izzotti, Filippo Ansaldi, Paolo Durando, Maria Teresa Piccardo
The impact of volatile organic compounds (VOCs) on indoor air quality and on human health is widely recognized. However, VOC contamination in hospital indoor air is rarely studied and chemical compounds that singularly do not show high toxicity are not submitted to any regulation. This study aimed to compare VOC contamination in two different anatomical pathology wards in the same hospital. Hydrocarbons, alcohols, and terpenes were sampled by passive diffusive samplers. Analytical tests were performed by thermal desorption coupled with gas chromatography and mass spectrometry detector...
June 7, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28588980/addressing-the-challenges-of-diagnostics-demand-and-supply-insights-from-an-online-global-health-discussion-platform
#16
Nora Engel, Keri Wachter, Madhukar Pai, Jim Gallarda, Catharina Boehme, Isabelle Celentano, Rebecca Weintraub
Several barriers challenge development, adoption and scale-up of diagnostics in low and middle income countries. An innovative global health discussion platform allows capturing insights from the global health community on factors driving demand and supply for diagnostics. We conducted a qualitative content analysis of the online discussion 'Advancing Care Delivery: Driving Demand and Supply of Diagnostics' organised by the Global Health Delivery Project (GHD) (http://www.ghdonline.org/) at Harvard University...
November 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28588969/it-is-time-to-revise-the-international-good-clinical-practices-guidelines-recommendations-from-non-commercial-north-south-collaborative-trials
#17
Raffaella Ravinetto, Halidou Tinto, Ermias Diro, Joseph Okebe, Yodi Mahendradhata, Suman Rijal, Eduardo Gotuzzo, Pascal Lutumba, Alain Nahum, Katelijne De Nys, Minne Casteels, Marleen Boelaert
The Good Clinical Practices (GCP) codes of the WHO and the International Conference of Harmonization set international standards for clinical research. But critics argue that they were written without consideration for the challenges faced in low and middle income countries (LMICs). Based on our field experience in LMICs, we developed a non-exhaustive set of recommendations for the improvement of GCP. These cover 3 domains: ethical, legal and operational, and 8 specific issues: the double ethical review of 'externally sponsored' trials; the informed consent procedure in minors and in illiterate people; post-trial access to newly-developed products for the trial communities; the role of communities as key research actors; the definition of sponsor; and the guidance for contractual agreements, laboratory quality management systems, and quality assurance of investigational medicinal products...
November 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28583421/gene-expression-profiles-in-mouse-cumulus-cells-derived-from-in%C3%A2-vitro-matured-oocytes-with-and-without-blastocyst-formation
#18
Yixin Xu, Tuanping Zhou, Li Shao, Bei Zhang, Kailu Liu, Chao Gao, Li Gao, Jiayin Liu, Yugui Cui, Ri-Cheng Chian
Cumulus cells (CCs) are considered as an important source to predict oocyte quality. Despite numerous candidate genes in CCs have been identified for embryonic developmental competence, the results are inconsistent. The next generation RNA-sequencing was used to investigate the transcriptomic differences in CCs from in vitro matured oocytes did or did not develop to blastocyst stage following in vitro fertilization (IVF). In our study, the corresponding mouse oocytes were traced using a single-cell tracking system, and CCs were pooled into groups based on the embryonic developmental outcomes...
June 2, 2017: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/28582498/microorganism-design-for-heterologous-biosynthesis-of-cannabinoids
#19
Carvalho Ângela, Esben Halkjær Hansen, Oliver Kayser, Simon Carlsen, Felix Stehle
During the last decade the use of medical Cannabis has expanded globally and legislation is getting more liberal in many countries, facilitating the research on cannabinoids. The unique interaction of cannabinoids with the human endocannabinoid system make these compounds an interesting target to be studied as a therapeutic agent for the treatment of several medical conditions. However, currently there are important limitations in the study, production and use of cannabinoids as pharmaceutical drugs. Besides the main constituent tetrahydrocannabinolic acid, the structurally related compound cannabidiol is of high interest as drug candidate...
June 4, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/28580394/intraskeletal-variation-in-human-cortical-osteocyte-lacunar-density-implications-for-bone-quality-assessment
#20
Randee L Hunter, Amanda M Agnew
Osteocytes and their lacunocanalicular network have been identified as the regulator of bone quality and function by exerting extensive influence over metabolic processes, mechanical adaptation, and mineral homeostasis. Recent research has shown that osteocyte apoptosis leads to a decrease in bone quality and increase in bone fragility mediated through its effects on remodeling. The purpose of this study is to investigate variation in cortical bone osteocyte lacunar density with respect to major factors including sex, age, and intracortical porosity to establish both regional and systemic trends...
December 2016: Bone Reports
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