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https://www.readbyqxmd.com/read/29052811/four-saccharomyces-species-differ-in-their-tolerance-to-various-stresses-though-they-have-similar-basic-physiological-parameters
#1
Jana Zemančíková, Marie Kodedová, Klára Papoušková, Hana Sychrová
Saccharomyces species, which are mostly used in the food and beverage industries, are known to differ in their fermentation efficiency and tolerance of adverse fermentation conditions. However, the basis of their difference has not been fully elucidated, although their genomes have been sequenced and analyzed. Five strains of four Saccharomyces species (S. cerevisiae, S. kudriavzevii, S. bayanus, and S. paradoxus), when grown in parallel in laboratory conditions, exhibit very similar basic physiological parameters such as membrane potential, intracellular pH, and the degree to which they are able to quickly activate their Pma1 H(+)-ATPase upon glucose addition...
October 20, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/29050248/low-dose-of-bisphenol-a-enhance-the-susceptibility-of-thyroid-carcinoma-stimulated-by-dhpn-and-iodine-excess-in-f344-rats
#2
Jing Zhang, Xiaochen Zhang, Yanan Li, Zhenzhen Zhou, Chuanlong Wu, Zhiyan Liu, Lanxiang Hao, Shanshan Fan, Fang Jiang, Yan Xie, Ling Jiang
Thyroid carcinoma (TC) is the most common endocrine neoplasm. The risk of TC as a second primary malignancy (SPM) of breast cancer is significantly increased. Bisphenol A (BPA) is a widely contacted xenoestrogen and increases susceptibility to breast cancer through binding to estrogen receptor alpha (ERα). However, the effect of BPA on thyroid carcinogenesis has not been fully demonstrated. This present study aimed to characterize the effects of BPA on the development of TC using a Fischer 344 (F344) rat model...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050230/a-potential-panel-of-two-long-non-coding-rna-signature-to-predict-recurrence-of-patients-with-laryngeal-cancer
#3
Zhigang Bai, Enhong Shi, Qiwei Wang, Zhouwei Dong, Ping Xu
Accumulating evidence has shown that aberrant lncRNA expression plays an oncogenic or tumor-suppressive role in the tumorigenesis of laryngeal cancer. However, the prognostic roles of lncRNAs in laryngeal cancer recurrence are still poorly understood. In this study, we obtained lncRNA expression profiles of 109 patients with laryngeal cancer by mining previously published gene expression microarray data from the Gene Expression Omnibus (GEO) and identified two lncRNAs associated with laryngeal cancer recurrence in the training dataset by using Cox regression analysis...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29044557/rice-phytoglobin-regulate-responses-under-low-mineral-nutrients-and-abiotic-stresses-in-arabidopsis-thaliana
#4
Alka Shankar, Joel Lars Fernandes, Kanwaljeet Kaur, Manisha Sharma, Suman Kundu, Girdhar K Pandey
Just like animals, plants also contain haemoglobins (known as phytoglobins in plants). Plant phytoglobins (Pgbs) have been categorized into six different classes viz. Phytogb0 (Pgb0), Phytogb1 (Pgb1), Phytogb2 (Pgb2), SymPhytogb (sPgb), Leghemoglobin (Lb) and Phytogb3 (Pgb3). Among the 6 Phytogbs, sPgb and Lb have been functionally characterized and the understanding of roles of other Pgbs is still evolving. In our present study, we have explored the function of two rice Pgbs (OsPgb1.1 and OsPgb1.2). OsPgb1...
October 17, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29043032/tracing-coco-de-mer-s-reproductive-history-pollen-and-nutrient-limitations-reduce-fecundity
#5
Emma J Morgan, Christopher N Kaiser-Bunbury, Peter J Edwards, Frauke Fleischer-Dogley, Chris J Kettle
Habitat degradation can reduce or even prevent the reproduction of previously abundant plant species. To develop appropriate management strategies, we need to understand the reasons for reduced recruitment in degraded ecosystems. The dioecious coco de mer palm (Lodoicea maldivica) produces by far the largest seeds of any plant. It is a keystone species in an ancient palm forest that occurs only on two small islands in the Seychelles, yet contemporary rates of seed production are low, especially in fragmented populations...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29035941/arterial-stiffness-and-cardiometabolic-phenotype-of-cameroonian-pygmies-and-bantus
#6
William Ngatchou, Daniel Lemogoum, Christian Mélot, Virginie Guimfacq, Philippe van de Borne, Jean Claude Wautrecht, Michel P Hermans, Luc Van Bortel, Marc Leeman
BACKGROUND: Pygmies living in the Central African rainforest with a traditional hunter-gatherer lifestyle have a low incidence of cardiovascular diseases. Because of progressive loss of traditional habitat and ancestral lands, some Pygmies have migrated to urban areas and adopt specific Bantu lifestyles such as increased salt consumption and a sedentary way of life. We tested the hypothesis that migrant Pygmies could present with hemodynamic and metabolic characteristics different from those of traditional in-situ Pygmies and possibly closer to those of Bantu farmers...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29034212/regulation-of-proliferation-by-a-mitochondrial-potassium-channel-in-pancreatic-ductal-adenocarcinoma-cells
#7
Roberta Peruzzo, Andrea Mattarei, Matteo Romio, Cristina Paradisi, Mario Zoratti, Ildikò Szabò, Luigi Leanza
Previous results link the mitochondrial potassium channel Kv1.3 (mitoKv1.3) to the regulation of apoptosis. By synthesizing new, mitochondria-targeted derivatives (PAPTP and PCARBTP) of PAP-1, a specific membrane-permeant Kv1.3 inhibitor, we have recently provided evidence that both drugs acting on mitoKv1.3 are able to induce apoptosis and reduce tumor growth in vivo without affecting healthy tissues and cells. In the present article, by exploiting these new drugs, we addressed the question whether mitoKv1...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29034175/refining-low-protein-modular-feeds-for-children-on-low-protein-tube-feeds-with-organic-acidaemias
#8
A Daly, S Evans, C Ashmore, S Chahal, S Santra, A MacDonald
Children with inherited metabolic disorders (IMD) who are dependent on tube feeding and require a protein restriction are commonly fed by 'modular tube feeds' consisting of several ingredients. A longitudinal, prospective two-phase study, conducted over 18 months assessed the long-term efficacy of a pre-measured protein-free composite feed. This was specifically designed to meet the non-protein nutritional requirements of children (aged over 1 year) with organic acidaemias on low protein enteral feeds and to be used as a supplement with an enteral feeding protein source...
December 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/29032538/trace-element-analysis-of-borrelia-burgdorferi-by-inductively-coupled-plasma-sector-field-mass-spectrometry
#9
Xin Li, Peng Wang, Anthony Lutton, John Olesik
Transition metal ions play important structural, regulatory, and catalytic roles in all biological systems by serving as cofactors for proteins. Due to their relatively low levels in the cell compared to abundant metal ions such as potassium and magnesium, transition metals are often considered micronutrients and referred to as trace elements. Manganese (Mn), iron (Fe), copper (Cu), and zinc (Zn) are the most prevalent transition metals in the Lyme disease spirochete Borrelia burgdorferi. Here, we describe a method for the accurate measurement of these trace elements in B...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29031357/regulation-of-potassium-homeostasis-in-ckd
#10
REVIEW
Thomas D DuBose
Disturbances of potassium homeostasis can cause either hyperkalemia or hypokalemia and result in serious consequences. Although the consequences of acute and chronic hyperkalemia and treatment of these conditions in CKD have been widely appreciated by nephrologists, more recent information has focused attention on the consequences of chronic hypokalemia. Several recent studies have documented a "U-shaped" relationship between the serum [K(+)] and higher mortality in several clinical studies. The causes of dyskalemias are placed into the unique perspective of patients with CKD and its evolution with progression of CKD to later stages and focuses on the pathophysiology of these disorders...
September 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29031279/rotationally-inelastic-collisions-of-excited-nak-and-nacs-molecules-with-noble-gas-and-alkali-atom-perturbers
#11
J Jones, K Richter, T J Price, A J Ross, P Crozet, C Faust, R F Malenda, S Carlus, A P Hickman, J Huennekens
We report measurements of rate coefficients at T ≈ 600 K for rotationally inelastic collisions of NaK molecules in the 2(A)(1)Σ(+) electronic state with helium, argon, and potassium atom perturbers. Several initial rotational levels J between 14 and 44 were investigated. Collisions involving molecules in low-lying vibrational levels (v = 0, 1, and 2) of the 2(A)(1)Σ(+) state were studied using Fourier-transform spectroscopy. Collisions involving molecules in a higher vibrational level, v = 16, were studied using pump/probe, optical-optical double resonance spectroscopy...
October 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29029515/discovery-of-nkcc1-as-a-potential-therapeutic-target-to-inhibit-hepatocellular-carcinoma-cell-growth-and-metastasis
#12
Yaya Zhou, Wei Sun, Ning Chen, Chen Xu, Xinxin Wang, Kun Dong, Binxue Zhang, Jian Zhang, Ning Hao, Aihua Sun, Handong Wei, Fuchu He, Ying Jiang
Metastasis is the essential cause for the high mortality of hepatocellular carcinoma (HCC). In order to investigate the mechanism of metastasis, and to discover therapeutic targets for HCC, the quantitative proteomic technique was applied to characterize the plasma membrane proteins of two HCC cell lines with low (MHCC97L) or high (MHCC97H) metastatic potentials. One of the plasma membrane proteins, sodium-potassium-chloride cotransporter 1 (NKCC1), was upregulated in MHCC97H cell line. Immunohistochemistry result in HCC patients showed that NKCC1 expression was associated with poor differentiation and microvascular invasion...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029044/enhanced-killing-of-escherichia-coli-using-a-combination-of-polyhexamethylene-biguanide-hydrochloride-and-1-bromo-3-chloro-5-5-dimethylimidazolidine-2-4-dione
#13
Wan Huai, Zhirui Deng, Wenshu Lin, Qin Chen
The bactericidal activities of polyhexamethylene biguanide hydrochloride (PHMB), 1-bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione (BCDMH), and the combination of the two (designated as PB) were compared using Escherichia coli as the test organism. PB exhibited strong bactericidal activity: 10 mg/L PHMB combined with 8 mg/L BCDMH resulted in approximately 5.74 log10 reduction (LR), whereby 320 mg/L PHMB or 20 mg/L BCDMH was about 5.53 and 6.56 LR, respectively. Analyses using scanning electron microscopy, flow cytometry, and atomic absorption spectroscopy indicated that PB, PHMB, and BCDMH disrupted cell membranes and changed membrane structure and permeability, resulting in the leakage of intracellular soluble proteins and ions...
October 4, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29027620/evaluation-of-the-tolerability-and-efficacy-of-sodium-polystyrene-sulfonate-for-long-term-management-of-hyperkalemia-in-patients-with-chronic-kidney-disease
#14
Panagiotis I Georgianos, Ioannis Liampas, Andreas Kyriakou, Vasilios Vaios, Vasilios Raptis, Nikolaos Savvidis, Athanasios Sioulis, Vassilios Liakopoulos, Elias V Balaskas, Pantelis E Zebekakis
PURPOSE: Sodium polystyrene sulfonate (SPS) is a cation-exchanging resin that has been widely used for several decades as first-line therapy of mild chronic hyperkalemia in patients with chronic kidney disease (CKD). However, evidence to prove the long-term tolerability and efficacy of SPS for the treatment of this condition is still missing. METHODS: In this retrospective, observational study, we enrolled 26 outpatients with stages 3-4 CKD who received oral therapy with low-dose SPS for mild chronic hyperkalemia in the Outpatient Nephrology clinic of our Department during 2010-2016...
October 11, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29026423/comprehensive-maternal-characteristics-associated-with-birth-weight-bayesian-modeling-in-a-prospective-cohort-study-from-iran
#15
Marjan Mansourian, Raziyeh Mohammadi, Hamid Reza Marateb, Akram Yazdani, Masoomeh Goodarzi-Khoigani, Sajedeh Molavi
BACKGROUND: In this study, we aimed to determine comprehensive maternal characteristics associated with birth weight using Bayesian modeling. MATERIALS AND METHODS: A total of 526 participants were included in this prospective study. Nutritional status, supplement consumption during the pregnancy, demographic and socioeconomic characteristics, anthropometric measures, physical activity, and pregnancy outcomes were considered as effective variables on the birth weight...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29022080/urinary-potassium-to-urinary-potassium-plus-sodium-ratio-can-accurately-identify-hypovolemia-in-nephrotic-syndrome-a-provisional-study
#16
Werner Keenswijk, Mohamad Ikram Ilias, Ann Raes, Raymond Donckerwolcke, Johan Vande Walle
There is evidence pointing to a decrease of the glomerular filtration rate (GFR) in a subgroup of nephrotic children, likely secondary to hypovolemia. The aim of this study is to validate the use of urinary potassium to the sum of potassium plus sodium ratio (UK/UK+UNa) as an indicator of hypovolemia in nephrotic syndrome, enabling detection of those patients who will benefit from albumin infusion. We prospectively studied 44 nephrotic children and compared different parameters to a control group (36 children)...
October 11, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29021371/consumption-of-a-double-fortified-salt-affects-perceptual-attentional-and-mnemonic-functioning-in-women-in-a-randomized-controlled-trial-in-india
#17
Michael J Wenger, Laura E Murray-Kolb, Julie Eh Nevins, Sudha Venkatramanan, Gregory A Reinhart, Annie Wesley, Jere D Haas
Background: Iron deficiency and iron deficiency anemia have been shown to have negative effects on aspects of perception, attention, and memory.Objective: The purpose of this investigation was to assess the extent to which increases in dietary iron consumption are related to improvements in behavioral measures of perceptual, attentional, and mnemonic function.Methods: Women were selected from a randomized, double-blind, controlled food-fortification trial involving ad libitum consumption of either a double-fortified salt (DFS) containing 47 mg potassium iodate/kg and 3...
October 11, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/29021336/pooled-analysis-of-multiple-crossover-trials-to-optimize-individual-therapy-response-to-renin-angiotensin-aldosterone-system-intervention
#18
Sergei I Petrykiv, Gozewijn Dirk Laverman, Frederik Persson, Liffert Vogt, Peter Rossing, Martin H de Borst, Ronald T Gansevoort, Dick de Zeeuw, Hiddo J L Heerspink
BACKGROUND AND OBJECTIVES: In the treatment of CKD, individual patients show a wide variation in their response to many drugs, including renin-angiotensin-aldosterone system inhibitors (RAASi). To investigate whether therapy resistance to RAASi can be overcome by uptitrating the dose of drug, changing the mode of intervention (with drugs from similar or different classes), or lowering dietary sodium intake, we meta-analyzed individual responses to different modes of interventions. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Randomized crossover trials were analyzed to assess correlation of individual responses to RAASi and nonsteroidal anti-inflammatory drugs (NSAIDs; n=395 patients)...
October 11, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29019912/validation-and-assessment-of-three-methods-to-estimate-24-h-urinary-sodium-excretion-from-spot-urine-samples-in-high-risk-elder-patients-of-stroke-from-the-rural-areas-of-shaanxi-province
#19
Wenxia Ma, Xuejun Yin, Ruijuan Zhang, Furong Liu, Danrong Yang, Yameng Fan, Jie Rong, Maoyi Tian, Yan Yu
Background: 24-h urine collection is regarded as the "gold standard" for monitoring sodium intake at the population level, but ensuring high quality urine samples is difficult to achieve. The Kawasaki, International Study of Sodium, Potassium, and Blood Pressure (INTERSALT) and Tanaka methods have been used to estimate 24-h urinary sodium excretion from spot urine samples in some countries, but few studies have been performed to compare and validate these methods in the Chinese population. Objective: To compare and validate the Kawasaki, INTERSALT and Tanaka formulas in predicting 24-h urinary sodium excretion using spot urine samples in 365 high-risk elder patients of strokefrom the rural areas of Shaanxi province...
October 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28994244/nitrogen-doped-carbon-nanotubes-derived-from-metal-organic-frameworks-for-potassium-ion-battery-anodes
#20
Peixun Xiong, Xinxin Zhao, Yunhua Xu
To tackle the issue of the poor rate capability of graphite anodes for potassium-ion batteries (KIBs), nitrogen-doped carbon nanotubes (NCNTs) with an edge-open layer-alignment structure were synthesized using a simple and scalable approach of pyrolyzing cobalt-containing metal-organic frameworks. The unique structure enables a facile and fast intercalation of K ions. As anodes of KIBs, the NCNTs demonstrated a superior rate capability by a high capacity retention of 102 mA h g-1 at a high current density of 2000 mA g-1 and a good stability without obvious capacity loss over 500 cycles at 2000 mA g-1...
October 10, 2017: ChemSusChem
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