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https://www.readbyqxmd.com/read/28643197/ampk-is-activated-early-in-cerebellar-granule-cells-undergoing-apoptosis-and-influences-vadc1-phosphorylation-status-and-activity
#1
A Bobba, E Casalino, G Amadoro, V A Petragallo, A Atlante
The neurodegeneration of cerebellar granule cells, after low potassium induced apoptosis, is known to be temporally divided into an early and a late phase. Voltage-dependent anion channel-1 (VDAC1) protein, changing from the closed inactive state to the active open state, is central to the switch between the early and late phase. It is also known that: (i) VDAC1 can undergo phosphorylation events and (ii) AMP-activated protein kinase (AMPK), the sensor of cellular stress, may have a role in neuronal homeostasis...
June 22, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28642930/a-novel-etching-technique-for-surface-treatment-of-zirconia-ceramics-to-improve-adhesion-of-resin-based-luting-cements
#2
Eystein Ivar Ruyter, Nalini Vajeeston, Torbjørn Knarvang, Ketil Kvam
Objectives: Bonding of zirconia crowns and bridges to abutments is important, not only bonding of the thin resin layer to the abutment, but also bonding to the zirconia ceramic is crucial. Both mechanical and chemical adhesion are desired. Mechanical retention of dental porcelain achieved by etching with moderately concentrated hydrofluoric acid is not possible with zirconia ceramics. The purpose of this study was to show that etching is possible with relative low melting fluoride compounds such as ammonium hydrogen difluoride and potassium hydrogen difluoride...
January 2017: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28638159/in-vitro-evaluation-of-the-fresenius-kabi-catsmart-autotransfusion-system
#3
Melissa Alberts, Robert C Groom, Richard Walczak, Robert Kramer, Adrienne Karpiel, Jeanette Dieter, Lisa Sheth, Nathaniel H Greene, Edmund H Jooste
Use of autotransfusion systems to collect, wash, and concentrate shed blood during surgical procedures is a widely used method for reducing postoperative anemia and the need for blood transfusions. The aim of this study was to evaluate the CATSmart Continuous Autotransfusion System wash program performance with small (200 or 700 mL) and large volumes (1,000 mL) of shed blood and to determine non-inferiority of the CATSmart to the C.A.T.S (plus) system. Human whole blood was collected in citrate phosphate dextrose, diluted, and divided into two aliquots to be processed as a pair using the C...
June 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/28630040/endoplasmic-reticulum-associated-degradation-of-the-renal-potassium-channel-romk-leads-to-type-ii-bartter-syndrome
#4
Brighid M O'Donnell, Timothy D Mackie, Arohan R Subramanya, Jeffrey L Brodsky
Type II Bartter syndrome is caused by mutations in the Renal Outer Medullary Potassium (ROMK) channel but the molecular mechanisms underlying this disease are poorly defined. To rapidly screen for ROMK function, we developed a yeast expression system and discovered that yeast cells lacking endogenous potassium channels could be rescued by WT ROMK but not by ROMK proteins containing one of four Bartter mutations. We also found that the mutant proteins were significantly less stable than WT ROMK. However, their degradation was slowed in the presence of a proteasome inhibitor or when yeast cells contained mutations in the CDC48 or SSA1 gene, which is required for endoplasmic reticulum (ER)-associated degradation (ERAD)...
June 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28628530/effects-of-salt-loading-and-potassium-supplement-on-the-circadian-blood-pressure-profile-in-salt-sensitive-chinese-patients
#5
Tong-Shuai Guo, Yi Dai, Ke-Yu Ren, Jian-Jun Mu, Jie Ren, Dan Wang, Yang Wang, Chao Chu, Yan Li, Zu-Yi Yuan
BACKGROUND AND OBJECTIVE: Salt-sensitive (SS) patients more frequently showed a nondipper blood pressure pattern and were associated with more serious target organ damage than non-SS patients. We aimed to investigate whether potassium supplement can improve the blunted nocturnal blood pressure fall in SS patients exposed to a high-salt diet. PATIENTS AND METHODS: Approximately 49 normotensive and mildly hypertensive Chinese patients received a study protocol of a 3 days of baseline examination, 7 days of a low-salt diet (3 g NaCl/day), 7 days of a high-salt diet (18 g NaCl/day), and 7 days of a high-salt diet with a potassium supplement (18 g NaCl and 4...
June 16, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28627193/-menus-offered-in-long-term-care-homes-quality-of-meal-service-and-nutritional-analysis
#6
Ana Isabel Rodríguez Rejón, María Dolores Ruiz López, Vincenzo Malafarina, Antonio Puerta, Antonia Zuñiga, Reyes Artacho
BACKGROUND: Institutionalization is a risk factor for malnutrition. Low energy intake and/or nutrient deficiencies are considered to be the main causes. OBJECTIVE: To evaluate the quality of meals and meal service as well as the nutritional value of the main menus (regular menu, menu for diabetics, and pureed menu) offered in three long-term care (LTC) homes located in the metropolitan area of Granada (Spain). METHODS: Cross-sectional study...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28625323/assessment-of-sodium-and-potassium-intake-by-24%C3%A2-h-urinary-excretion-in-a-healthy-mexican-cohort
#7
Maite Vallejo, Eloisa Colín-Ramírez, Susana Rivera Mancía, Raúl Cartas Rosado, Magdalena Madero, Oscar Infante Vázquez, Jesús Vargas-Barrón
BACKGROUND AND AIMS: A high dietary sodium intake and a low potassium intake are associated with adverse cardiovascular health. Data on these nutrients consumption in Mexico is limited. The aim of this study was to assess sodium and potassium intake by 24 h urinary excretion in a clinically healthy Mexican population. We additionally explored their association with blood pressure. METHODS: 711 clinically healthy participants aged 20-50 years old recruited in the Tlalpan 2020 cohort from September 2014-December 2015, were included in this cross-sectional analysis...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28624887/voriconazole-induced-qt-prolongation-among-hemato-oncologic-patients-clinical-characteristics-and-risk-factors
#8
I Gueta, R Loebstein, N Markovits, Y Kamari, H Halkin, G Livni, H Yarden-Bilavsky
PURPOSE: The purpose of this study is to determine the rate of QTcP and associated risk factors in patients treated with voriconazole. METHODS: We conducted a retrospective chart review of all patients treated with voriconazole in a large tertiary center between 2009 and 2015, using paired comparison of QTc intervals on and off voriconazole treatment, adjusted for comorbidities, electrolyte abnormalities, and concurrent medications. RESULTS: Fifty-four patients were included, of whom 53 were diagnosed with oncologic/hemato-oncologic disease...
June 17, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28623364/distribution-and-kinetics-of-the-kv1-3-blocking-peptide-hstx1-r14a-in-experimental-rats
#9
Ralf Bergmann, Manja Kubeil, Kristof Zarschler, Sandeep Chhabra, Rajeev B Tajhya, Christine Beeton, Michael W Pennington, Michael Bachmann, Raymond S Norton, Holger Stephan
The peptide HsTX1[R14A] is a potent and selective blocker of the voltage-gated potassium channel Kv1.3, which is a highly promising target for the treatment of autoimmune diseases and other conditions. In order to assess the biodistribution of this peptide, it was conjugated with NOTA and radiolabelled with copper-64. [(64)Cu]Cu-NOTA-HsTX1[R14A] was synthesised in high radiochemical purity and yield. The radiotracer was evaluated in vitro and in vivo. The biodistribution and PET studies after intravenous and subcutaneous injections showed similar patterns and kinetics...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28623022/heterogeneity-of-zeolite-combined-with-biochar-properties-as-a-function-of-sewage-sludge-composting-and-production-of-nutrient-rich-compost
#10
Mukesh Kumar Awasthi, Meijing Wang, Ashok Pandey, Hongyu Chen, Sanjeev Kumar Awasthi, Quan Wang, Xiuna Ren, Altaf Hussain Lahori, Dong-Sheng Li, Ronghua Li, Zengqiang Zhang
In the present study, biochar combined with a higher dosage of zeolite (Z) and biochar (B) alone were applied as additives for dewatered fresh sewage sludge (DFSS) composting using 130-L working volume lab-scale reactors. We first observed that the addition of a mixture of B and Z to DFSS equivalent to 12%B+10% (Z-1), 15% (Z-2) and 30% (Z-3) zeolite (dry weight basis) worked synergistically as an amendment and increased the composting efficiency compared with a treatment of 12%B alone amended and a control without any amendment...
June 13, 2017: Waste Management
https://www.readbyqxmd.com/read/28620410/transcriptome-analysis-of-differentially-expressed-genes-induced-by-low-and-high-potassium-levels-provides-insight-into-fruit-sugar-metabolism-of-pear
#11
Changwei Shen, Jie Wang, Xiaoqian Shi, Yalong Kang, Changyan Xie, Lirun Peng, Caixia Dong, Qirong Shen, Yangchun Xu
Potassium (K) deficiency is a common abiotic stress that can inhibit the growth of fruit and thus reduce crop yields. Little research has been conducted on pear transcriptional changes under low and high K conditions. Here, we performed an experiment with 7-year-old pot-grown "Huangguan" pear trees treated with low, Control or high K levels (0, 0.4, or 0.8 g·K2O/kg soil, respectively) during fruit enlargement and mature stages. We identified 36,444 transcripts from leaves and fruit using transcriptome sequencing technology...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28620187/discovery-and-identification-of-o-o-diethyl-o-4-5-phenyl-4-5-dihydroisoxazol-3-yl-phenyl-phosphorothioate-xp-1408-as-a-novel-mode-of-action-of-organophosphorus-insecticides
#12
Zhigang Zeng, Ying Yan, Bingfeng Wang, Niu Liu, Hanhong Xu
Organophosphorus (OP) insecticides play an important role in pest control. Many OP insecticides have been removed from the market because of their high toxicity to humans. We designed and synthesized a new OP insecticide with the goal of providing a low cost, and less toxic insecticide. The mode of action of O, O-diethyl O-(4-(5-phenyl-4, 5-dihydroisoxazol-3-yl) phenyl) phosphorothioate (XP-1408) was studied in Drosophila melanogaster. Bioassays showed that XP-1408 at a concentration of 50 mg/L delayed larval development...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619993/low-extracellular-potassium-prolongs-repolarization-and-evokes-early-afterdepolarization-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#13
Jukka Kuusela, Kim Larsson, Disheet Shah, Chandra Prajapati, Katriina Aalto-Setälä
Long QT syndrome (LQTS) is characterized by a prolonged QT-interval on electrocardiogram and by increased risk of sudden death. One of the most common and potentially life-threatening electrolyte disturbances is hypokalemia, characterized by low concentrations of K(+) Using a multielectrode array platform and current clamp technique, we investigated the effect of low extracellular K(+) concentration ([K(+)]Ex) on the electrophysiological properties of hiPSC-derived cardiomyocytes (CMs) generated from a healthy control subject (WT) and from two symptomatic patients with type 1 of LQTS carrying G589D (LQT1A) or IVS7-2A>G mutation (LQT1B) in KCNQ1 The baseline prolongations of field potential durations (FPDs) and action potential durations (APDs) were longer in LQT1-CMs than in WT-CMs...
June 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28619748/pore-polarity-and-charge-determine-differential-block-of-kir1-1-and-kir7-1-potassium-channels-by-the-small-molecule-inhibitor-vu590
#14
Sujay Kharade, Jonathan Sheehan, Eric Figueroa, Jens Meiler, Jerod Denton
VU590 was the first publicly disclosed, sub-micromolar-affinity (IC50=0.2 µM), small-molecule inhibitor of the inward rectifier potassium (Kir) channel, Kir1.1, an emerging diuretic target for the treatment of hypertension. VU590 also inhibits Kir7.1, albeit with 40-fold lower potency (IC50~8 µM), and has been used as a Kir7.1 tool compound to uncover new roles of the channel in regulation of myometrial contractility and melanocortin signaling in the brain. Here, we employed molecular modeling, site-directed mutagenesis, and patch clamp electrophysiology to elucidate the molecular mechanisms underlying inhibition of Kir1...
June 15, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28618365/a-highly-sensitive-and-widely-adaptable-plasmonic-aptasensor-using-berberine-for-small-molecule-detection
#15
Jin-Ho Park, Ju-Young Byun, Hyungjun Jang, Donggu Hong, Min-Gon Kim
Localized surface plasmon resonance (LSPR) biosensors allow label-free detection of small molecules in molecular binding events; however, they are limited by a relatively low sensitivity and narrow dynamic range. Here, we report highly sensitive small-molecule detection by LSPR peak shift exploiting the G-quadruplex (GQx) structure-binding characteristic of known GQx binders to enhance the LSPR signal of a plasmonic aptasensor. Six known GQx binders (thiazole orange, malachite green, crystal violet, zinc protoporphyrin IX, thioflavin T, and berberine) were tested for their ability to enhance the LSPR signal...
June 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28616635/angiostrongylus-cantonensis-an-optimized-cultivation-of-this-parasitic-nematode-under-laboratory-conditions
#16
Hui Xie, Dongjuan Yuan, Shiqi Luo, Xingda Zeng, Xin Zeng, Ping He, Zhiyue Lv, Zhongdao Wu
Angiostrongylus cantonensis (A. cantonensis), a parasitic nematode, is the important neurotropic pathogen which causes human angiostrongyliasis. It has a complex life-cycle and severe parasite-host interaction in contrast to free-living nematode. Establishment of a well-suited life-cycle and in vitro cultivation of A. cantonensis in the laboratory will be one of the key techniques to elucidate the mechanism of parasite-host interaction. However, the low survival and growth rate of worms is still to be the problem...
June 14, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28615265/adequacy-of-nutritional-intake-from-food-and-supplements-in-a-cohort-of-pregnant-women-in-qu%C3%A3-bec-canada-the-3d-cohort-study-design-develop-discover
#17
Lise Dubois, Maikol Diasparra, Brigitte Bédard, Cynthia K Colapinto, Bénédicte Fontaine-Bisson, Anne-Sophie Morisset, Richard E Tremblay, William D Fraser
Background: Assessments of the dietary intakes in various populations suggest that pregnant women have difficulty meeting all their nutritional requirements through diet alone. Few large-scale studies have considered both food sources and supplements in assessing the adequacy of nutritional intakes during pregnancy.Objectives: Our study aimed to assess nutritional intakes during pregnancy by examining dietary sources and supplements. It then compared these findings with Dietary Reference Intakes.Design: We conducted a nutrition study in a large pregnancy cohort using a 3-d food record during the second trimester of pregnancy...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28615142/overexpression-of-kcnj2-in-induced-pluripotent-stem-cell-derived-cardiomyocytes-for-the-assessment-of-qt-prolonging-drugs
#18
Min Li, Yasunari Kanda, Takashi Ashihara, Tetsuo Sasano, Yuji Nakai, Masami Kodama, Erina Hayashi, Yuko Sekino, Tetsushi Furukawa, Junko Kurokawa
Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes hold great potentials to predict pro-arrhythmic risks in preclinical cardiac safety screening, although the hiPSC cardiomyocytes exhibit rather immature functional and structural characteristics, including spontaneous activity. Our physiological characterization and mathematical simulation showed that low expression of the inward-rectifier potassium (IK1) channel is a determinant of spontaneous activity. To understand impact of the low IK1 expression on the pharmacological properties, we tested if transduction of hiPSC-derived cardiomyocytes with KCNJ2, which encodes the IK1 channel, alters pharmacological response to cardiac repolarization processes...
May 27, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28614828/relationship-between-sodium-intake-and-water-intake-the-false-and-the-true
#19
Lise Bankir, Julie Perucca, Peter Norsk, Nadine Bouby, Morten Damgaard
Generally, eating salty food items increases thirst. Thirst is also stimulated by the experimental infusion of hypertonic saline. But, in steady state, does the kidney need a higher amount of water to excrete sodium on a high than on a low sodium intake? This issue is still controversial. The purpose of this review is to provide examples of how the kidney handles water in relation to salt intake/output. It is based on re-analysis of previously published studies in which salt intake was adjusted to several different levels in the same subjects, and in databases of epidemiologic studies in populations on an ad libitum diet...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28614439/residual-volume-in-vials-of-antibiotics-used-in-pediatrics
#20
Caroline Magna Pessoa Chaves, Carolina Martins Bezerra, Francisca Elisângela Teixeira Lima, Maria Vera Lúcia Moreira Leitão Cardoso, Said Gonçalves da Cruz Fonseca, Viviane Martins da Silva
OBJECTIVE: Quantifying residual volume contained in vials of antibiotics used in pediatrics. METHOD: This is an experiment involving samples from vials of antibiotics used in a pediatric hospital. Residual volume was identified by calculating the difference in weight measurement before and after the vials were washed. Evaluation of the residual volume difference in the vials was determined by the Wilcoxon non-parametric test for a sample and established at a significance level of 5%...
June 12, 2017: Revista da Escola de Enfermagem da U S P
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