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https://www.readbyqxmd.com/read/29458115/effect-of-acek-acesulfame-potassium-on-brain-function-under-dietary-restriction-in-mice
#1
Daisuke Ibi, Fumika Suzuki, Masayuki Hiramatsu
People preferably take zero or low-calorie beverages and foods with artificial sweeteners even though it has been recently suggested that long-term artificial sweetener use affects physiological functions. In addition, a lower body weight was considered to be more healthful, but an abnormally low body weight caused by an excessive diet has been reported to cause health problems. Acesulfame potassium (AceK) is one of the most commonly used for foods and beverages because of its resistance to thermal degradation and marked sweetness...
February 16, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29455335/evaluating-the-safety-and-tolerability-of-sacubitril-valsartan-for-hfref-managed-within-a-pharmacist-clinic
#2
Elizabeth K Pogge, Lindsay E Davis
OBJECTIVE: The objective of this research was to describe the use of pharmacist-managed sacubitril/valsartan therapy in a multi-center, outpatient cardiac group. BACKGROUND: Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor (ARNi), is a novel agent for the treatment of heart failure. An ARNi is recommended by national guidelines to be used in place of angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) therapy for patients who remain symptomatic...
February 17, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29454924/transformation-of-methylparaben-by-aqueous-permanganate-in-the-presence-of-iodide-kinetics-modeling-and-formation-of-iodinated-aromatic-products
#3
Juan Li, Jin Jiang, Su-Yan Pang, Yang Zhou, Yuan Gao, Yi Yang, Shaofang Sun, Guanqi Liu, Jun Ma, Chengchun Jiang, Lihong Wang
This work investigated impacts of iodide (I- ) on the transformation of the widely used phenolic preservative methylparaben (MeP) as well as 11 other phenolic compounds by potassium permanganate (KMnO4 ). It was found that KMnO4 showed a low reactivity towards MeP in the absence of I- with apparent second-order rate constants (kapp ) ranging from 0.065 ± 0.0071 to 1.0 ± 0.1 M-1 s-1 over the pH range of 5-9. The presence of I- remarkably enhanced the transformation rates of MeP by KMnO4 via the contribution of hypoiodous acid (HOI) in situ formed, which displayed several orders of magnitude higher reactivity towards MeP than KMnO4 ...
February 10, 2018: Water Research
https://www.readbyqxmd.com/read/29453047/influence-of-potassium-hydroxide-activation-on-characteristics-and-environmental-risk-of-heavy-metals-in-chars-derived-from-municipal-sewage-sludge
#4
Zhengjia Li, Hui Deng, Le Yang, Genlin Zhang, Yuqi Li, Yansen Ren
To investigate the influence of KOH activation on characteristics and environmental risk of heavy metals in chars, sludge was pyrolyzed with varying amount of KOH. The analyzation of characteristics and potential ecological risk evaluation of heavy metals were conducted by surface area analyzer, FTIR, XRD and BCR sequential extraction. The activated chars have higher surface area and lower content of silica compared to those without being activated. The activation of KOH promoted residual fraction of Cd, meanwhile, Zinc, Cr, Ni and Mn were converted to relatively unstable fractions (F2 and F3)...
February 7, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29451094/growth-and-optimization-of-carbon-nanotubes-in-powder-activated-carbon-for-an-efficient-removal-of-methylene-blue-from-aqueous-solution
#5
Haiyam Mohammed Alayan, Mohammed Abdulhakim Alsaadi, Mohammed Khaled AlOmar, Mohd Ali Hashim
This work demonstrated the synthesis of carbon nanotubes (CNTs) on powder activated carbon (PAC) impregnated with Ni-catalyst through chemical vapor deposition. The optimized effects of reaction temperature, time and feedstock flow rates on CNT growth were examined. Potassium permanganate (KMnO 4 ) and potassium permanganate in acidic solution (KMnO 4 /H 2 SO 4 ) were used to functionalize CNTs samples. A primary screening of methylene blue (MB) adsorption was conducted. The chemical, physical and morphological properties of the adsorbent with the highest removal efficiency were investigated using FESEM, EDX, TEM, BET surface area, RAMAN, TGA, FTIR, and zeta potential...
February 16, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29450200/nutritional-compositions-and-phytochemical-properties-of-the-edible-flowers-from-selected-zingiberaceae-found-in-thailand
#6
Apinya Rachkeeree, Kuttiga Kantadoung, Ratchuporn Suksathan, Ratchadawan Puangpradab, Paul Alexander Page, Sarana Rose Sommano
The nutritional compositions and phytochemical properties of eight edible flowers of the ginger family (Zingiberaceae) commonly found in Thailand are reported herein. The plant genera investigated were Zingiber (Ginger, Phlai Dam, Krathue), Hedychium (two morphological filament forms), Curcuma (Ao), Etlingera (Torch ginger), Amomum (Chi Kuk), and Alpinia (Galangal), which are eaten fresh or cooked as ingredients in the preparation of many Thai dishes. The proximate compositions (moisture, ash, fiber, protein, fat, and carbohydrate contents) varied among the different genera...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29448745/nanostructured-biomass-based-carbon-materials-from-beer-lees-for-hydrogen-storage
#7
M S Balathanigaimani, Md Belal Haider, Divyam Jha, Rakesh Kumar, Seung Jae Lee, Wang Geun Shim, Ho Kyong Shon, Sang Chai Kim, Hee Moon
The present work describes the preparation of carbon materials from beer lees and their hydrogen adsorption abilities. Activated carbons (ACs) from beer lees were prepared through chemical activation using potassium hydroxide as an activating agent. The low temperature nitrogen adsorption isotherm studies on prepared ACs were conducted at 77 K to determine their physical properties and adsorption energy distribution. The beer lees based carbons have energetically heterogeneous surfaces and high surface area ranging from 1927-2408 m2/g...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447970/development-of-a-new-paper-based-nano-biosensor-based-on-the-co-catalytic-effect-of-tyrosinase-from-banana-peel-tissue-musa-cavendish-and-functionalized-silica-nanoparticles-for-voltammetric-determination-of-l-tyrosine
#8
Mohadeseh Rahimi-Mohseni, Jahan Bakhsh Raoof, Reza Ojani, Tahereh A Aghajanzadeh, Ayemeh Bagheri Hashkavayi
A new and facile method for electrochemical determination of L-tyrosine was designed. Tyrosinase from banana peel tissue was immobilized at fiber matrices of the paper disc via physical adsorption. The mediator potassium hexacyanoferrate and 3-mercaptopropyl trimethoxysilane-functionalized silica nanoparticles were added to the paper disc, respectively. The modified paper disc was placed on the top of the graphite screen printed electrode and electrochemical characterization of this biosensor was studied by cyclic voltammetry and electrochemical impedance spectroscopy methods...
February 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29447674/green-modified-micellar-liquid-chromatography-for-isocratic-isolation-of-some-cardiovascular-drugs-with-different-polarities-through-experimental-design-approach
#9
Amir M Ramezani, Ghodratollah Absalan, Raheleh Ahmadi
Bilayer pseudo-stationary phase micellar liquid chromatography (MLC) was developed for simultaneous isocratic isolation of hydrochlorothiazide, as a basic-polar (hydrophilic) cardiovascular drug, as well as triamterene and losartan potassium, as acidic-nonpolar (hydrophobic) cardiovascular drugs. Utilizing a deep eutectic solvent (DES), as a novel green mobile phase additive in combination with acetonitrile (ACN) and acetic acid (ACA), drastically improved the chromatographic behavior of the drugs. Concentration of sodium dodecyl sulphate (SDS), as well as volume percentages of ACN, DES, and ACA were optimized by using a central composite design...
June 20, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29442813/prostate-cancer-cell-specific-cytotoxicity-of-sub-micron-potassium-niobate-powder
#10
John G Fisher, Ung Trong Thuan, Muhammad Umer Farooq, Gopalakrishnan Chandrasekaran, Young Do Jung, Eu Chang Hwang, Je-Jung Lee, Vinoth-Kumar Lakshmanan
Oxide nanoparticles have numerous potential applications in medicine such as carriers for therapeutic drugs, contrast agents for bio-imaging and targeting agents for tumors. Oxide nanoparticles may also have an inherent cytotoxicity towards cancer cells, as recently found for cerium oxide. KNbO3 nanoparticles have a combination of low toxicity and nonlinear optical properties which make them attractive for use as a bio-imaging material. However, little is known yet about the cytotoxicity of KNbO3 particles towards cancerous cells...
May 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442257/effect-of-long-term-fertilization-strategies-on-bacterial-community-composition-in-a-35-year-field-experiment-of-chinese-mollisols
#11
Mingchao Ma, Jing Zhou, Marc Ongena, Wenzheng Liu, Dan Wei, Baisuo Zhao, Dawei Guan, Xin Jiang, Jun Li
Bacteria play vital roles in soil biological fertility; however, it remains poorly understood about their response to long-term fertilization in Chinese Mollisols, especially when organic manure is substituted for inorganic nitrogen (N) fertilizer. To broaden our knowledge, high-throughput pyrosequencing and quantitative PCR were used to explore the impacts of inorganic fertilizer and manure on bacterial community composition in a 35-year field experiment of Chinese Mollisols. Soils were collected from four treatments: no fertilizer (CK), inorganic phosphorus (P) and potassium (K) fertilizer (PK), inorganic P, K, and N fertilizer (NPK), and inorganic P and K fertilizer plus manure (MPK)...
February 13, 2018: AMB Express
https://www.readbyqxmd.com/read/29435989/improved-potassium-nutrition-retrieves-phosphorus-induced-decrease-in-uptake-and-grain-zinc-concentration-of-wheat
#12
Asif Naeem, Muhammad Aslam, Asma Lodhi
BACKGROUND: The negative effect of soil applied phosphorus (P) on zinc (Zn) uptake by plants and concentration in food grains could be a possible reason of low dietary intake of Zn. Likewise its critical role in plant tolerance to other abiotic stresses, potassium (K) was thought to retrieve P induced decrease in grain Zn concentration of wheat. To test the above hypothesis, effect of K application (50 mg kg-1 soil) on Zn concentration in shoot/grains and its shoot-to-grain translocation was studied in wheat (Triticum aestivum L, cv Galaxy 2013) under low and optimal supply of both P (10 and 50 mg kg-1 ) and Zn (0 and 5 mg kg-1 )...
February 13, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29435033/prognostic-significance-of-sodium-potassium-atpase-regulator-fxyd3-in-human-hepatocellular-carcinoma
#13
Li-Juan Wang, Qi-Jiong Li, Yong Le, Han-Yue Ouyang, Min-Ke He, Zi-Shan Yu, Yong-Fa Zhang, Ming Shi
The clinical significance of the sodium-potassium ATPase regulator FXYD domain-containing ion transport regulator 3 (FXYD3) has been demonstrated in a number of types of cancer. However, the role of this protein in human hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, 217 HCC tissue samples were analyzed to evaluate the expression and prognostic significance of FXYD3 in HCC. Reverse transcription-quantitative polymerase chain reaction was used to analyze the mRNA expression of FXYD3 in 80 primary HCC specimens and paired non-cancerous liver tissue samples, while western blotting was used to analyze the protein expression level of FXYD3 in another 24 pairs...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29430331/an-active-alkali-exchanged-faujasite-catalyst-for-p-xylene-production-via-the-one-pot-diels-alder-cycloaddition-dehydration-reaction-of-2-5-dimethylfuran-with-ethylene
#14
Roderigh Y Rohling, Evgeny Uslamin, Bart Zijlstra, Ionut C Tranca, Ivo A W Filot, Emiel J M Hensen, Evgeny A Pidko
The one-pot Diels-Alder cycloaddition (DAC)/dehydration (D) tandem reaction between 2,5-dimethylfuran and ethylene is a potent pathway toward biomass-derived p-xylene. In this work, we present a cheap and active low-silica potassium-exchanged faujasite (KY, Si/Al = 2.6) catalyst. Catalyst optimization was guided by a computational study of the DAC/D reaction mechanism over different alkali-exchanged faujasites using periodic density functional theory calculations complemented by microkinetic modeling. Two types of faujasite models were compared, i...
February 2, 2018: ACS Catalysis
https://www.readbyqxmd.com/read/29429959/low-resting-membrane-potential-and-low-inward-rectifier-potassium-currents-are-not-inherent-features-of-hipsc-derived-cardiomyocytes
#15
András Horváth, Marc D Lemoine, Alexandra Löser, Ingra Mannhardt, Frederik Flenner, Ahmet Umur Uzun, Christiane Neuber, Kaja Breckwoldt, Arne Hansen, Evaldas Girdauskas, Hermann Reichenspurner, Stephan Willems, Norbert Jost, Erich Wettwer, Thomas Eschenhagen, Torsten Christ
Human induced pluripotent stem cell (hiPSC) cardiomyocytes (CMs) show less negative resting membrane potential (RMP), which is attributed to small inward rectifier currents (IK1). Here, IK1 was measured in hiPSC-CMs (proprietary and commercial cell line) cultured as monolayer (ML) or 3D engineered heart tissue (EHT) and, for direct comparison, in CMs from human right atrial (RA) and left ventricular (LV) tissue. RMP was measured in isolated cells and intact tissues. IK1 density in ML- and EHT-CMs from the proprietary line was similar to LV and RA, respectively...
February 7, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29429337/cathode-dependence-of-liquid-alloy-na-k-anodes
#16
Leigang Xue, Hongcai Gao, Yutao Li, John B Goodenough
Alkali ions can be plated dendrite-free into a liquid alkali-metal anode. Commercialized Na-S battery technology operates above 300°C. A low-cost Na-K alloy is liquid at 25°C from 9.2 to 58.2 wt% of sodium; sodium and/or potassium can be plated dendrite-free in the liquid range at room temperature. The co-existence of two alkali metals in an anode raises a question: whether the liquid Na-K alloy acts as a Na or a K anode. Here we show the alkali-metal that is stripped from the liquid Na-K anode is dependent on the preference of the cathode host...
February 11, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29420940/triethylamine-assisted-mg-oh-2-coprecipitation-preconcentration-for-determination-of-trace-metals-and-rare-earth-elements-in-seawater-by-inductively-coupled-plasma-mass-spectrometry-icp-ms
#17
Zikri Arslan, Tulay Oymak, Jeremy White
In this paper, we report an improved magnesium hydroxide, Mg(OH)2, coprecipitation method for the determination of 16 trace elements (Al, V, Cr, Mn, Mn, Fe, Co, Ni, Cu, Zn, Ga, As, Se, Sb, Sn and Pb) and 18 rare earth elements (REEs), including Sc, Y, U and Th in seawater and estuarine water samples. The procedure involves coprecipitation of the trace elements and REEs on Mg(OH)2 upon addition of a small volume of triethylamine (TEA) followed by analysis of the dissolved pellet solutions by inductively coupled plasma mass spectrometry (ICP-MS)...
May 30, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29419914/early-laser-intervention-to-reduce-scar-formation-a-systematic-review
#18
REVIEW
K Karmisholt, A Haerskjold, T Karlsmark, J Waibel, U Paasch, M Haedersdal
The ability of laser treatment to affect wound healing and subsequently minimize scar formation has been investigated in recent years. However, no systematic review links these clinical trials. The aim of this study is to systematically review and evaluate clinical evidence for early laser intervention to reduce scar formation in studies where laser treatment were introduced less than 3 months after wounding. We searched PubMed using relevant key words in June 2017. Titles, abstracts and articles were sorted according to inclusion and exclusion criteria...
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29419865/-screening-of-genetic-mutations-in-a-chinese-pedigree-affected-with-hypokalemic-periodic-paralysis
#19
Manli Guo, Guowen Zhang, Shaogang Ma, Tie Xu, Yigen Peng
OBJECTIVE To screen for mutations in a Chinese pedigree affected with hypokalemic periodic paralysis. METHODS The proband and nine family members were enrolled for the analysis of CACNA1S and SCN4A gene mutations. Genomic DNA was extracted from peripheral blood samples. The coding regions of the two genes were amplified with PCR and subjected to Sanger sequencing. Potential impact of suspected mutations was predicted with Bioinformatics software. The mutations were also verified among 100 healthy controls. RESULTS The proband and 5 family members (including 5 males and 1 female) had presented with episodes of flaccid paralysis accompanied by low serum potassium...
February 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29416503/resonance-properties-in-auditory-brainstem-neurons
#20
Linda Fischer, Christian Leibold, Felix Felmy
Auditory signals carry relevant information on a large range of time scales from below milliseconds to several seconds. Different stages in the auditory brainstem are specialized to extract information in specific frequency domains. One biophysical mechanism to facilitate frequency specific processing are membrane potential resonances. Here, we provide data from three different brainstem nuclei that all exhibit high-frequency subthreshold membrane resonances that are all most likely based on low-threshold potassium currents...
2018: Frontiers in Cellular Neuroscience
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