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JOURNAL ARTICLE
Sai Sreenidhi Ram, Daniel Stricker, Carine Pannetier, Nathalie Tabin, Richard W Costello, Daiana Stolz, Kevin W Eva, Sören Huwendiek
BACKGROUND: With conference attendees having expressed preference for hybrid meeting formats (containing both in-person and virtual components), organisers are challenged to find the best combination of events for academic meetings. Better understanding what attendees prioritise in a hybrid conference should allow better planning and need fulfilment. METHODS: An online survey with closed and open-ended questions was distributed to registrants of an international virtual conference...
April 9, 2024: BMC Medical Education
#2
JOURNAL ARTICLE
Santosh Kumar Banjara, Sai Ram Challa, Little Flower Augustine, Teena Dasi, Radhika Madhari, Sylvia Fernandez Rao, Ravindranadh Palika, Raghu Pullakhandam, Rajender Rao Kalashikam, Ramachandrappa Naveen Kumar, Dharani Pratyusha Palepu, Monica Chilumula, Kiruthika Selvaraj, Preethi Gopinath, Hilary Davies-Kershaw, Modou Lamin Jobarteh, Paul Haggarty, Claire Heffernan, Elaine Ferguson, Bharati Kulkarni
INTRODUCTION: Evidence on the impact of nutrient-rich animal source foods such as eggs for improving child growth and cognition is inconsistent. This study aims to examine the impact of an egg intervention in children, along with behaviour change communication (BCC) to the mother, on linear growth and cognition, and nutritional status in children aged 9-18 months. METHODS AND ANALYSIS: A 9-month open-labelled randomised controlled trial will be conducted in three urban slums in Hyderabad, India, as a substudy of an observational cohort study (n=350) following pregnant women and their children until 18 months of age in a population at risk of stunting...
February 27, 2024: BMJ Paediatrics Open
#3
Sai Dharmarajan, Zhong Yuan, Yeh-Fong Chen, Leila Lackey, Saurabh Mukhopadhyay, Pritibha Singh, Ram Tiwari
No abstract text is available yet for this article.
February 12, 2024: Therapeutic Innovation & Regulatory Science
#4
JOURNAL ARTICLE
S P Somashekhar, Elroy Saldanha, Rohit Kumar, Ashma Monteiro, Sai Ram Pillarisetti, K R Ashwin
INTRODUCTION: Chyle leak is a serious complication following oesophagectomy with incidence varies from 1% to 9%. Near infra-red fluorescence imaging of thoracic duct (TD) can provide real-time dynamic imaging during the surgery. In this study, we intend to compare indocyanine green (ICG) dye instillation through inguinal node with subcutaneous first web space instillation for visualisation of TD during robotic-assisted minimally invasive oesophagectomy (RAMIE) procedure. PATIENTS AND METHODS: A prospective study of 50 patients underwent RAMIE with da Vinci X System...
February 9, 2024: Journal of Minimal Access Surgery
#5
REVIEW
Lakshmi Venkata Simhachalam Kutikuppala, Sushil Sharma, Madhavrao Chavan, Gaurav Rangari, Arup Kumar Misra, Sai Ram Innamuri, Tejus Vijayakumar, Golla Varshitha
Cardiovascular disease (CVD) is the most common cause of morbidity and mortality worldwide. Bromocriptine is a partial antagonist for D1 dopamine receptors while also serving as a selective agonist on D2 dopamine receptors as a dopamine receptor agonist. Apart from prolactin inhibiting action, bromocriptine has some beneficial effects on the blood pressure, plasma norepinephrine levels and vascular resistance. Dopamine D2 receptor activation of bromocriptine is associated with the antihypertensive effect, which lowers blood pressure via inhibiting sympathetic nerve activity and Na/K ATPase activity...
February 2024: Annals of Medicine and Surgery
#6
JOURNAL ARTICLE
Sai Dharmarajan, Zhong Yuan, Yeh-Fong Chen, Leila Lackey, Saurabh Mukhopadhyay, Pritibha Singh, Ram Tiwari
BACKGROUND: Multiple criteria decision analysis (MCDA) and stochastic multi-criteria acceptability analysis (SMAA) in their current implementation cannot incorporate prior or external information on benefits and risks. We demonstrate how to incorporate prior data using a Bayesian mixture model approach while conducting quantitative benefit-risk assessments (qBRA) for medical products. METHODS: We implemented MCDA and SMAA in a Bayesian framework. To incorporate information from a prior study, we use mixture priors on each benefit and risk attribute that mixes information from a previous study with a vague prior distribution...
January 24, 2024: Therapeutic Innovation & Regulatory Science
#7
JOURNAL ARTICLE
Smitha Sammith Shetty, Mohit Sharma, Kanaka Sai Ram Padam, Adarsh Kudva, Pratik Patel, Raghu Radhakrishnan
BACKGROUND: Oral submucous fibrosis (OSF) is a persistent oral mucosal condition that carries an elevated risk of undergoing malignant transformation. Our objective was to elucidate the involvement of epithelial-to-mesenchymal transition (EMT) in OSF and its progression to malignancy by studying a panel of EMT markers, thereby understanding the molecular mechanisms. METHODS: An immunohistochemical analysis was done to detect the presence of E-cadherin, N-cadherin, pan-cytokeratin (PanCK), vimentin, α-SMA (alpha-smooth muscle actin), and CD44 in a total of 100 tissue samples...
2024: Journal of Oral Biology and Craniofacial Research
#8
JOURNAL ARTICLE
Gadde Praveen, Manchikatla Sravani, Chaitanya Ram Kadiyala, Sai Lakshmi Durga Indukuri, Uls Poornima, Sravani Pampana
BACKGROUND: Community health depends on the leadership duties of a diverse population, such as village volunteers. Hence, a study was conducted to assess oral health status, treatment needs, and patterns of utilization of dental services among village volunteers in Andhra Pradesh state. METHODOLOGY: A cross-sectional study was conducted among 400 village volunteers in Andhra Pradesh state, India. A multi-stage cluster sampling procedure was employed in sample selection...
November 2023: Journal of Family Medicine and Primary Care
#9
JOURNAL ARTICLE
Kanaka Sai Ram Padam, Sanjiban Chakrabarty, Keith D Hunter, Raghu Radhakrishnan
OBJECTIVE: Understanding the regulatory role of homeobox (HOX) and mutated genes in the progression of head and neck cancers is essential, although their interaction remains elusive. This study aims to decipher the critical regulation of mutation driven effects on homeobox genes to enhance our understanding of head and neck cancer progression. METHODS: Genomic mutation data from The Cancer Genome Atlas-Head and Neck Squamous Cell Carcinoma were analyzed using VarScan2 for somatic variant detection...
December 15, 2023: Archives of Oral Biology
#10
JOURNAL ARTICLE
Vikas Nishadham, Rashmi Santhoshkumar, Saraswati Nashi, Seena Vengalil, Mainak Bardhan, Kiran Polavarapu, Sai Bhargava Sanka, Ram Murthy Anjanappa, Karthik Kulanthaivelu, Jitender Saini, Yasha T Chickabasaviah, Atchayaram Nalini
Charcot-Marie-Tooth disease 4H(CMT4H) is an autosomal recessive demyelinating form of CMT caused by FGD4/FRABIN mutations. CMT4H is characterized by early onset and slowly progressing motor and sensory deficits in the distal extremities, along with foot deformities. We describe a patient with CMT4H who presented with rapidly progressing flaccid quadriparesis during the postpartum period, which improved significantly with steroid therapy. Magnetic resonance imaging and ultrasonography demonstrated considerable nerve thickening with increased cross-sectional area in the peripheral nerves...
December 11, 2023: Journal of Neuromuscular Diseases
#11
REVIEW
Usha Topalkatti, Ram Chandra Prasad, Bhagya Raju Koppu, Kalva Suchitra Reddy, Siddhanth Kumar Mekala, Rajarahulnaik Banothu, Hemanth Vasireddy, Renuka Sri Sai Peddireddi
"Aortic stenosis" (AS) refers to a cardiac condition in which the aortic valve narrows, creating an obstruction that hinders the flow of blood from the left ventricle to the aorta. This contraction of the arteries influences normal blood circulation, leading to elevated pressure within the left ventricle and potentially culminating in heart failure. The management of AS typically involves two primary treatments, i.e. "surgical aortic valve replacement" (SAVR) and "transcatheter aortic valve replacement" (TAVR)...
October 2023: Curēus
#12
JOURNAL ARTICLE
Sai Ram Pillarisetti, Chandra Kanneganti, Azeem Majeed, Kaveh Asanati
No abstract text is available yet for this article.
November 10, 2023: BJGP Open
#13
REVIEW
Nikhil Sai Jagarlamudi, Kriti Soni, Saima S Ahmed, Naga Sai Ram Makkapati, Sujaritha Janarthanam, Cristhian R Vallejo-Zambrano, Khushbu C Patel, Roshni Xavier, Praveen Kumar Ponnada, Iqra Zaheen, Muhammad Ehsan
Survivors of out-of-hospital cardiac arrest (OHCA) experience significant mortality rates and neurological impairment, potentially attributed to the hypoxic-ischemic injury sustained amid the cardiac arrest episode. Post-resuscitation care plays a crucial role in determining outcomes for survivors of OHCA. Supportive therapies have proven to be influential in shaping these outcomes. However, targeting higher blood pressure or oxygen levels during the post-resuscitative phase has not been shown to offer any mortality or neurological benefits...
September 2023: Curēus
#14
REVIEW
Vaibhav Vats, Kriyesha Patel, Dhruvikumari D Sharma, Naiela E Almansouri, Naga Sai Ram Makkapati, Simran Nimal, Palash Ramteke, Bushra Mohammed Arifuddin, Nikhil Sai Jagarlamudi, Archit Narain, Yogesh D Raut
Systemic vasculitides encompass a cluster of autoimmune diseases that affect blood vessels, and are characterized by immune-mediated injury to either small- or large-sized blood vessels. Individuals afflicted with systemic vasculitides experience notable morbidity and mortality attributable to cardiovascular manifestations. Noteworthy among these are ischemic heart disease, venous thromboembolism, aortic involvement, valvular irregularities, myocarditis, and pericarditis. This narrative review investigated and evaluated the prevalent cardiovascular disturbances commonly associated with different types of vasculitides...
August 2023: Curēus
#15
JOURNAL ARTICLE
Kiran Polavarapu, Balaraju Sunitha, Ana Töpf, Veeramani Preethish-Kumar, Rachel Thompson, Seena Vengalil, Saraswati Nashi, Mainak Bardhan, Sai Bhargava Sanka, Akshata Huddar, Gopikrishnan Unnikrishnan, Gautham Arunachal, Manu Santhappan Girija, Anna Porter, Yoshiteru Azuma, Paulo José Lorenzoni, Dipti Baskar, Ram Murthy Anjanappa, Madassu Keertipriya, Hansashree Padmanabh, Ganaraja Valakunja Harikrishna, Steve Laurie, Leslie Matalonga, Rita Horvath, Atchayaram Nalini, Hanns Lochmüller
Congenital myasthenic syndromes are a rare group of inherited disorders caused by gene defects associated with the neuromuscular junction and potentially treatable with commonly available medications such as acetylcholinesterase inhibitors and beta2 adrenergic receptor agonists. In this study we identify and genetically characterise the largest cohort of congenital myasthenic syndrome patients from India to date. Clinically suspected patients evaluated in a South Indian hospital between 2014-2019 underwent genetic testing either by standard diagnostic methods of gene panel testing or a two-step method of hotspot screening followed by whole-exome sequencing...
September 18, 2023: Brain
#16
JOURNAL ARTICLE
Pruthvish Reddy, Sushma Pradeep, Gopinath S M, Chandan Dharmashekar, Disha G, Sai Chakith M R, Chandrashekar Srinivasa, Ali A Shati, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Raghu Ram Achar, Ekaterina Silina, Victor Stupin, Natalia Manturova, Chandan Shivamallu, Shiva Prasad Kollur
Breast cancer is a leading cause of mortality in women, and alternative therapies with fewer side effects are actively being explored. Breast cancer is a significant global health concern, and conventional treatments like radiotherapy and chemotherapy often have side effects. Medicinal plant extracts offer a promising avenue for the development of effective and safe anticancer therapies. Terminalia chebula , a plant known for its medicinal properties, was selected for investigation in this study. We aimed to assess the antiproliferative effects of TCF extract on breast cancer cells and explore the potential role of saccharopine, a phytochemical found in TCF, as an anticancer agent...
2023: Frontiers in Oncology
#17
JOURNAL ARTICLE
Sai Krishna Susarla, Madhu Gupta, Kheya Ghosh Uttam, Sonali Palkar, Ashish Ramachandra Dhongade, K Siva Ram Prasad, Vasudev Rajapantula, M D Ravi, N Pradeep, M Satish, B C Rajashakar, G Sandhya, L Rajendra, Devi Prasad Sahoo, Anand Kumar Kanakasapapathy
BACKGROUND: Hepatitis A is an inflammation of the liver caused by the hepatitis A virus (HAV). It is transmitted mainly because of poor personal hygiene via the faecal/oral route through ingestion of contaminated food or water or through the direct contact with an infectious person. Though most of the infected individuals recover from the infection, a few may develop fatal fulminant hepatitis. In this randomized, multicenter study, immunogenicity and safety of Havisure™ vaccine of Human Biologicals Institute was compared with Havrix® vaccine...
September 1, 2023: Vaccine
#18
JOURNAL ARTICLE
Unai Pascual, Patricia Balvanera, Christopher B Anderson, Rebecca Chaplin-Kramer, Michael Christie, David González-Jiménez, Adrian Martin, Christopher M Raymond, Mette Termansen, Arild Vatn, Simone Athayde, Brigitte Baptiste, David N Barton, Sander Jacobs, Eszter Kelemen, Ritesh Kumar, Elena Lazos, Tuyeni H Mwampamba, Barbara Nakangu, Patrick O'Farrell, Suneetha M Subramanian, Meine van Noordwijk, SoEun Ahn, Sacha Amaruzaman, Ariane M Amin, Paola Arias-Arévalo, Gabriela Arroyo-Robles, Mariana Cantú-Fernández, Antonio J Castro, Victoria Contreras, Alta De Vos, Nicolas Dendoncker, Stefanie Engel, Uta Eser, Daniel P Faith, Anna Filyushkina, Houda Ghazi, Erik Gómez-Baggethun, Rachelle K Gould, Louise Guibrunet, Haripriya Gundimeda, Thomas Hahn, Zuzana V Harmáčková, Marcello Hernández-Blanco, Andra-Ioana Horcea-Milcu, Mariaelena Huambachano, Natalia Lutti Hummel Wicher, Cem İskender Aydın, Mine Islar, Ann-Kathrin Koessler, Jasper O Kenter, Marina Kosmus, Heera Lee, Beria Leimona, Sharachchandra Lele, Dominic Lenzi, Bosco Lliso, Lelani M Mannetti, Juliana Merçon, Ana Sofía Monroy-Sais, Nibedita Mukherjee, Barbara Muraca, Roldan Muradian, Ranjini Murali, Sara H Nelson, Gabriel R Nemogá-Soto, Jonas Ngouhouo-Poufoun, Aidin Niamir, Emmanuel Nuesiri, Tobias O Nyumba, Begüm Özkaynak, Ignacio Palomo, Ram Pandit, Agnieszka Pawłowska-Mainville, Luciana Porter-Bolland, Martin Quaas, Julian Rode, Ricardo Rozzi, Sonya Sachdeva, Aibek Samakov, Marije Schaafsma, Nadia Sitas, Paula Ungar, Evonne Yiu, Yuki Yoshida, Eglee Zent
Twenty-five years since foundational publications on valuing ecosystem services for human well-being1,2 , addressing the global biodiversity crisis3 still implies confronting barriers to incorporating nature's diverse values into decision-making. These barriers include powerful interests supported by current norms and legal rules such as property rights, which determine whose values and which values of nature are acted on. A better understanding of how and why nature is (under)valued is more urgent than ever4 ...
August 9, 2023: Nature
#19
JOURNAL ARTICLE
Nithish Sattoju, Santosh Gattu, Sai Sashank Merugu, Vydhika Anneboina, Sai Ram Ganapaka
INTRODUCTION: The aim of this study was to demonstrate the purpose of adding antiviral (remdesivir) to the existing steroidal (dexamethasone) therapy in treating coronavirus disease 2019 (COVID-19). METHODOLOGY: A retrospective observational case cohort study was carried out to compare the effect of dexamethasone alone and in combination with remdesivir in treating moderate and severe COVID-19 disease. The patients were divided into 2 groups: Group 1 included patients treated with dexamethasone alone, and Group 2 included patients treated with dexamethasone and remdesivir...
July 27, 2023: Journal of Infection in Developing Countries
#20
JOURNAL ARTICLE
Satya Sai Ram Kumar Gulla, Elvera Helberg, Rajesh Vikram Vagiri
BACKGROUND: Positive mental health (PMH) forms the basis of well-being and positive mind set, which includes a range of cognitive-emotional attributes and coping skills of an individual towards the family and society. Assessment of PMH in psychiatric patients is critical in understanding their needs, improving mental health and the treatment of their illnesses. AIM: To investigate the levels of PMH among patients attending the outpatient department at a public sector tertiary referral psychiatric hospital using the multidimensional PMH instrument...
2023: South African Journal of Psychiatry: SAJP
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