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Sai Ram

Prasad Sreevathsa, Duvuru Ram, Hemachandren Munuswamy, Davulury Sri Satyavathi, Bathal Vedagiri Sai Chandran
Left ventricular pseudoaneurysms are very rare in children. In children, left ventricular pseudoaneurysms can occur following infection, trauma, ischemia, or cardiac surgery. The authors report a series of three cases treated at our hospital with two of the cases having a history of extrapulmonary tuberculosis and one patient with a history of varicella zoster infection.
January 1, 2018: World Journal for Pediatric & Congenital Heart Surgery
Yogesh Taneja, Priyatama Ram, Satish Kumar, Kishan Raj, Charan K Singh, Santosh K Dhaked, Jiten Jaipuria
Background: Lower urinary tract symptoms (LUTSs) due to benign prostatic hyperplasia (BPH) are common conditions in middle-age or older men. The International Prostate Symptom Score (IPSS) is a useful and validated questionnaire to evaluate LUTS secondary to BPH. Van der Walt et al have developed an alternative questionnaire named the Visual Prostate Symptom Score (VPSS) questionnaire. This study aimed to evaluate the relationship between the VPSS and IPSS in the evaluation of men with LUTSs due to BPH in an Indian population...
December 2017: Prostate International
Karthik Reddy Kami Reddy, Chandrashekhar Dasari, Divya Duscharla, Bhukya Supriya, N Sai Ram, M V Surekha, Jerald Mahesh Kumar, Ramesh Ummanni
Tissue microarray analysis confirmed higher dimethylarginine dimethylaminohydrolase-1 (DDAH1) expression in prostate cancer (PCa) compared to benign and normal prostate tissues. DDAH1 regulates nitric oxide (NO) production by degrading endogenous nitric oxide synthase (NOS) inhibitor, asymmetric dimethylarginine (ADMA). This study examined whether DDAH1 has any physiological role in PCa progression. Using overexpression of DDAH1 in PCa (PC3 and LNCaP) cell lines, we found that DDAH1 promotes cell proliferation, migration and invasion by lowering ADMA levels, as well as increasing NO production...
February 2018: Angiogenesis
Sai Krishna Tikka, Umesh Shreekantiah, Asha Krishnan, Nishant Goyal, S Haque Nizamie, Daya Ram
Cognitive processes underlying reciprocal social interactions are understood by the mechanism of embodiment, which is closely related to the mirror neuron system. Electroencephalographic (EEG) mu activity is a neural marker of the mirror neuron system. This study investigated the mu activity, localization of its sources and functional connectivity, which was induced while watching reciprocal social interactive motion across various degrees of complexity. Eighteen healthy participants underwent high-resolution EEG recording using 256-channels while they watched a specifically designed, culture specific, video task that showed two persons interacting socially using body gestures...
August 2016: Asian Journal of Psychiatry
Biswajit Medhi, Gopalakrishna M Hegde, Sai Siva Gorthi, Kalidevapura Jagannath Reddy, Debasish Roy, Ram Mohan Vasu
A simple noninterferometric optical probe is developed to estimate wavefront distortion suffered by a plane wave in its passage through density variations in a hypersonic flow obstructed by a test model in a typical shock tunnel. The probe has a plane light wave trans-illuminating the flow and casting a shadow of a continuous-tone sinusoidal grating. Through a geometrical optics, eikonal approximation to the distorted wavefront, a bilinear approximation to it is related to the location-dependent shift (distortion) suffered by the grating, which can be read out space-continuously from the projected grating image...
August 1, 2016: Applied Optics
Bindu Raghavan, Kayla Erickson, Abirami Kugadas, Sai A Batra, Douglas R Call, Margaret A Davis, William J Foreyt, Subramaniam Srikumaran
In the absence of livestock contact, recurring lamb mortality in bighorn sheep (Ovis canadensis) populations previously exposed to pneumonia indicates the likely presence of carriers of pneumonia-causing pathogens, and possibly inadequate maternally derived immunity. To investigate this problem we commingled naïve, pregnant ewes (n=3) with previously exposed rams (n=2). Post-commingling, all ewes and lambs born to them acquired pneumonia-causing pathogens (leukotoxin-producing Pasteurellaceae and Mycoplasma ovipneumoniae), with subsequent lamb mortality between 4-9 weeks of age...
2016: Biology Open
Sathish Babu Vasamsetti, Santosh Karnewar, Raja Gopoju, Paradesi Naidu Gollavilli, Sai Ram Narra, Jerald Mahesh Kumar, Srigiridhar Kotamraju
Monocyte-to-macrophage differentiation promotes an inflammatory environment within the arterial vessel wall that causes a mal-adaptive immune response, which contributes to the progression of atheromatous plaque formation. In the current study, we show that resveratrol, a well-known antioxidant, dose-dependently attenuated phorbol myristate acetate (PMA)-induced monocyte-to-macrophage differentiation, as measured by cell adhesion, increase in cell size, and scavenger receptor expression in THP-1 monocytes. Also, resveratrol significantly inhibited PMA-induced pro-inflammatory cytokine/chemokine and matrix metalloprotease (MMP-9) production...
July 2016: Free Radical Biology & Medicine
A Vikram Simha Reddy, A Ravi Prakash, V Sai Ram, K L Keerthana, Rukmini Swathi Thorati
Fibrosarcoma has been defined as a malignant mesenchymal tumour, the cells of which recapitulate the appearance of the normal fibroblast, with variable collagen production. Fibrosarcoma is a very uncommon tumour in the head and neck regions constituting only 0.05% of all the fibrosarcomas presenting in humans. They cause no characteristic symptoms and pose difficulty in clinical diagnosis. They have been classified histologically based on their distinct features into myxoid fibrosarcoma, low grade fibromyxoid fibrosarcoma and sclerosing epitheloid sarcoma...
July 2015: Journal of Clinical and Diagnostic Research: JCDR
Chada Narsimha Reddy, V Lakshma Nayak, Geeta Sai Mani, Jeevak Sopanrao Kapure, Praveen Reddy Adiyala, Ram Awatar Maurya, Ahmed Kamal
Libraries of spiro[cyclopropane-1,3'-indolin]-2'-ones were synthesized and evaluated for their biological activity against five different human cancer cell lines HT-29 (colon cancer), DU-145 (prostate cancer), Hela (cervical cancer), A-549 (Lung cancer), and MCF-7 (breast cancer). Many compounds of the series exhibited promising anticancer activity (IC50<20 μM) against the studied cell lines. Based on the screening results, a structure activity relationship (SAR) of the pharmacophore was proposed. Among the series compound 6b and 6u showed significant activity against human prostate cancer cell line, DU-145...
October 15, 2015: Bioorganic & Medicinal Chemistry Letters
Praveen Reddy Adiyala, Geeta Sai Mani, Jagadeesh Babu Nanubolu, Kunta Chandra Shekar, Ram Awatar Maurya
A novel strategy for the synthesis of imidazo[1,2-a]pyridines via efficient catalyst/metal-free annulations of α-keto vinyl azides and 2-aminopyridines is described. Several imidazo[1,2-a]pyridines were synthesized from readily available vinyl azides and 2-aminopyridines and obtained in highly pure form by simply evaporating the reaction solvent. This remarkably high yielding and atom economical protocol allows the formation of three new C-N bonds through cascade reactions and rearrangements.
September 4, 2015: Organic Letters
Ahmed Kamal, K N Visweswara Sastry, D Chandrasekhar, Geeta Sai Mani, Praveen Reddy Adiyala, Jagadeesh Babu Nanubolu, Kiran Kumar Singarapu, Ram Awatar Maurya
An operationally simple and high yielding protocol for the synthesis of polyfunctional pyrazoles has been developed through one-pot, three-component coupling of aldehydes, 1,3-dicarbonyls, and diazo compounds as well as tosyl hydrazones. The reaction proceeds through a tandem Knoevenagel condensation, 1,3-dipolar cycloaddition, and transition metal-free oxidative aromatization reaction sequence utilizing molecular oxygen as a green oxidant. The scope of the reaction was studied by varying the aldehyde, 1,3-dicarbonyl, and diazo component individually...
May 1, 2015: Journal of Organic Chemistry
Sai Sunil Kishore, Sapna Oberoi, Anish Bhattacharya, Rajender Prasad, Amita Trehan, Deepak Bansal, Ram Kumar Marwaha
Long-term damage to the residual kidney is of concern in the survivors of Wilms tumor. Our objective was to evaluate the long-term glomerular function and size of the residual kidney in these patients. Twenty-nine survivors of Wilms tumor diagnosed between July 1999 and June 2004 were enrolled. The glomerular function was assessed by creatinine clearance, 99mTc DTPA radionuclide scintigraphy and 24-hour urinary protein. Renal size was evaluated by ultrasonography. Median age at diagnosis and at enrollment were 2...
February 2015: Pediatric Hematology and Oncology
Deyashini Lahiri Tikka, Daya Ram, Indu Dubey, Sai Krishna Tikka
BACKGROUND: Alcohol-dependent patients are traditionally believed to have insecure attachment styles, higher anger expression, and lower self-esteem. There is a need to study them together. AIM: To understand the relationships amongst various of the socio-emotional factors. MATERIALS AND METHODS: Forty male patients with Alcohol dependence syndrome and 40 matched healthy controls (General Health Questionnaire-12 score <3) were compared on attachment styles (on Relationship Scale Questionnaire), anger domains (on State Trait Anger Expression Inventory), and self-esteem (on Rosenberg Self-esteem Scale)...
April 2014: Indian Journal of Psychological Medicine
Youssef M K Farag, Bharati V Mittal, Sai Ram Keithi-Reddy, Vidya N Acharya, Alan F Almeida, Anil C, H S Ballal, P Gaccione, R Issacs, Sanjiv Jasuja, A L Kirpalani, V Kher, G K Modi, Georgy Nainan, Jai Prakash, Mohan M Rajapurkar, D S Rana, Rajanna Sreedhara, D K Sinha, Bharat V Shah, Sham Sunder, Raj Kumar Sharma, Sridevi Seetharam, Tatapudi Ravi Raju, Ajay K Singh
BACKGROUND: Hypertension (HTN) is one of the major causes of cardiovascular morbidity and mortality. The objective of the study was to investigate the burden and predictors of HTN in India. METHODS: 6120 subjects participated in the Screening and Early Evaluation of Kidney disease (SEEK), a community-based screening program in 53 camps in 13 representative geographic locations in India. Of these, 5929 had recorded blood pressure (BP) measurements. Potential predictors of HTN were collected using a structured questionnaire for SEEK study...
March 6, 2014: BMC Nephrology
M Sai Ram, G Seenayya
Clostridium thermocellum strains SS8 and GS1 grew poorly on crude blopolymers but termented them easily after alkall treatment. With 1% alkall-extracted rice straw (AERS) and dellgnified bamboo pulp (DBP), the ethanol-to-substrate (E/S) ratios were almost the same as those obtained when using fillter paper. Increasing the substrate concentrations decreased the percentage substrate degraded and the E/S ratio and concomitantly increased the amount of reducing sugars accumulated. A maximum amount of 8.6 g ethanol/l was produced by strain SS8 out of 37...
May 1991: World Journal of Microbiology & Biotechnology
M Sai Ram, C V Rao, G Seenayya
Clostridium thermocellum SS8 produced both carboxymethylcellulase (CMCase) and Avicelase when grown on cellulose. CMCase activity was unaffected by Ca(2+), Mg(2+), dithionate or dithiothreitol (DTT). Avicelase activity increased 2-fold with 5 mM DTT and 10 mM Ca(2+). Cellulase and amylase were produced when a celluloseadapted culture was grown on starch. The mould grew best on sucrose and was inhibited by NaCl above 10 g/l.
March 1991: World Journal of Microbiology & Biotechnology
Ajay Ram Srimath Kandada, Giulia Grancini, Annamaria Petrozza, Stefano Perissinotto, Daniele Fazzi, Sai Santosh Kumar Raavi, Guglielmo Lanzani
It is common knowledge that poly(3-hexylthiophene) (P3HT)/[6,6]-phenyl-C61-butyric acid methyl ester (PCBM) blend, a prototype system for bulk heterojunction (BHJ) solar cells, consists of a network of tens of nanometers-large donor-rich and acceptor-rich phases separated by extended finely intermixed border regions where PCBM diffuse into P3HT. Here we specifically address the photo-induced dynamics in a 10 nm thin P3HT/PCBM blend that consists of the intermixed region only. Using the multi-pass transient absorption technique (TrAMP) that enables us to perform ultra high sensitive measurements, we find that the primary process upon photoexcitation is ultrafast energy transfer from P3HT to PCBM...
2013: Scientific Reports
Ajay K Singh, Youssef M K Farag, Bharati V Mittal, Kuyilan Karai Subramanian, Sai Ram Keithi Reddy, Vidya N Acharya, Alan F Almeida, Anil Channakeshavamurthy, H Sudarshan Ballal, Gaccione P, Rajan Issacs, Sanjiv Jasuja, Ashok L Kirpalani, Vijay Kher, Gopesh K Modi, Georgy Nainan, Jai Prakash, Devinder Singh Rana, Rajanna Sreedhara, Dilip Kumar Sinha, Shah Bharat V, Sham Sunder, Raj K Sharma, Sridevi Seetharam, Tatapudi Ravi Raju, Mohan M Rajapurkar
BACKGROUND: There is a rising incidence of chronic kidney disease that is likely to pose major problems for both healthcare and the economy in future years. In India, it has been recently estimated that the age-adjusted incidence rate of ESRD to be 229 per million population (pmp), and >100,000 new patients enter renal replacement programs annually. METHODS: We cross-sectionally screened 6120 Indian subjects from 13 academic and private medical centers all over India...
2013: BMC Nephrology
Sikander P Surana, Patrick H Pun, Sai Ram Keithi-Reddy, Steven M Spiegel, John P Middleton, Ajay K Singh
End-stage renal disease (ESRD) carries a significant risk for sudden cardiac arrest (SCA), hospitalization and mortality. We present a case of a vintage hemodialysis patient who had a catastrophic event during his hemodialysis treatment - a sudden cardiac arrest. This case raises several important issues: First, patients with chronic kidney disease (CKD) (and particularly ESRD) are predisposed to an inordinate risk of SCA; second, the factors leading to SCA in CKD are unique; and lastly, it is of paramount importance to have basic life support training, crash carts and defibrillators in dialysis units...
February 2014: Clinical Nephrology
Youssef M K Farag, Sai Ram Keithy-Reddy, Bharati V Mittal, Vinod Bansal, Jaweed Fareed, Ajay K Singh
BACKGROUND: Clinical trials demonstrate either no benefit or increased risk of cardiovascular events and mortality in patients with chronic kidney disease (CKD) targeted for higher hemoglobin levels, who are treated with erythropoiesis-stimulating agents (ESAs). The mechanism underlying this observation remains unexplained. METHODS AND RESULTS: We assessed platelet activation by measuring soluble P-selectin (sPsel), CD40 ligand (CD40L), and circulating microparticles (CMP) in patients with CKD...
September 2012: Clinical and Applied Thrombosis/hemostasis
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