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https://www.readbyqxmd.com/read/27873215/current-and-future-treatment-approaches-in-transthyretin-familial-amyloid-polyneuropathy
#1
REVIEW
Philippe Kerschen, Violaine Planté-Bordeneuve
Treatment of transthyretin familial amyloid polyneuropathy (TTR FAP) must be tailored to disease stage. Patients with early stage disease (i.e., without major impairment in walking ability), especially younger patients, should be referred as soon as possible for liver transplantation (LT) in the absence of major comorbid conditions. LT remains the most effective treatment option to date and should be offered to these patients as early as possible. Bridging therapy with an oral TTR stabilizer (tafamidis or diflunisal, according to local access to these treatments) should be started as soon as the diagnosis of TTR FAP is established...
December 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27771996/how-regenerative-medicine-stakeholders-adapt-to-ever-changing-technology-and-regulatory-challenges-snapshots-from-the-world-termis-industry-symposium-september-10-2015-boston
#2
Yves Bayon, Mark Van Dyke, Robert Buelher, Ross Tubo, Tim Bertram, Bernard Malfroy-Camine, Michelle Rathman, Vincent Ronfard
Regenerative medicine (RM) is a fascinating area of research and innovation. The huge potential of the field has been fairly underexploited so far. Both TERMIS-AM and TERMIS-EU Industry Committees are committed to mentoring and training young entrepreneurs for more successful commercial translation of upstream research. With this objective in mind, the two entities jointly organized an industry symposium during the past TERMIS World Congress (Boston, September 8-11, 2015) and invited senior managers of the RM industry for lectures and panel discussions...
November 21, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27710829/eliciting-regret-improves-decision-making-at-the-end-of-life
#3
Benjamin Djulbegovic, Athanasios Tsalatsanis, Rahul Mhaskar, Iztok Hozo, Branko Miladinovic, Howard Tuch
INTRODUCTION: Management choices at the end of life are high-stake decisions fraught with emotions, chief among is regret. Our objective in this paper is to test the utility of a regret-based model to facilitate referral to hospice care while helping patients clarify their preferences on how they wish to spend the remaining days of their lives. METHODS: A prospective cohort study that enrolled consecutive adult patients (n = 178) aware of the terminal nature of their disease...
October 3, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27599455/time-trends-in-physician-visits-for-gastroesophageal-reflux-disease-before-and-after-the-rx-to-otc-switch-of-proton-pump-inhibitors
#4
Dong W Chang, Jonathan Grotts, Chi-Hong Tseng, Eric P Brass
No abstract text is available yet for this article.
October 6, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27598489/-impact-of-secondary-prophylaxis-in-the-management-of-patients-with-high-recurrence-risk-of-urolithiasis
#5
Enrique Ossandón S, Francisco Sepúlveda T, Cristián Acevedo C
UNLABELLED: In a previous study, we showed our experience in a group of 54 patients with a high risk of urolithiasis recurrence, who were subjected to a complete metabolic evaluation. AIM: To report the evolution of these patients after 5 years of follow-up. PATIENTS AND METHODS: All patients underwent a general management of urolithiasis plus specific treatments for underlying metabolic disorders. Each patient had an annual medical assessment including a clinical examination, urinalysis and imaging studies (non-enhanced computed tomography scan, ultrasonography and plain abdominal Rx rays)...
June 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27583928/effect-of-opioid-prescribing-guidelines-in-primary-care
#6
Jonathan H Chen, Jason Hom, Ilana Richman, Steven M Asch, Tanya Podchiyska, Nawal Atwan Johansen
Long-term opioid use for noncancer pain is increasingly prevalent yet controversial given the risks of addiction, diversion, and overdose. Prior literature has identified the problem and proposed management guidelines, but limited evidence exists on the actual effectiveness of implementing such guidelines in a primary care setting.A multidisciplinary working group of institutional experts assembled comprehensive guidelines for chronic opioid prescribing, including monitoring and referral recommendations. The guidelines were disseminated in September 2013 to our medical center's primary care clinics via in person and electronic education...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27538037/methods-of-a-national-colorectal-cancer-cohort-study-the-piper-project
#7
Melissa J Firth, Katrina J Sharples, Victoria A Hinder, Jerome Macapagal, Diana Sarfati, Sarah L Derrett, Andrew G Hill, Charis Brown, Papaarangi Mj Reid, Ross A Lawrenson, Carol Atmore, John P Keating, Mark Jeffery, Adrian H Secker, Charles De Groot, Christopher Gca Jackson, Michael Pn Findlay
AIM: Colorectal cancer is one of the most common cancers, and second-leading cause of cancer-related death, in New Zealand. The PIPER (Presentations, Investigations, Pathways, Evaluation, Rx [treatment]) project was undertaken to compare presentation, investigations, management and outcomes by rurality, ethnicity and deprivation. This paper reports the methods of the project, a comparison of PIPER patient diagnoses to the New Zealand Cancer Registry (NZCR) data, and the characteristics of the PIPER cohort...
2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27494453/endoscopic-treatment-of-sporadic-small-duodenal-and-ampullary-neuroendocrine-tumors
#8
Rodica Gincul, Thierry Ponchon, Bertrand Napoleon, Jean-Yves Scoazec, Olivier Guillaud, Jean-Christophe Saurin, Mihai Ciocirlan, Vincent Lepilliez, Mathieu Pioche, Christine Lefort, Mustapha Adham, Jean Pialat, Jean-Alain Chayvialle, Thomas Walter
Background and study aim: As duodenal neuroendocrine tumors (NETs) are rare, their optimal management has not been clearly established. The aim of this study was to evaluate the feasibility and outcome of endoscopic treatment of duodenal NETs. Patients and methods: We reviewed the files of all patients who underwent endoscopic resection of a sporadic duodenal or ampullary NET between 1996 and 2014 at two centers. Results: A total of 29 patients with 32 uT1N0M0 NETs < 20 mm were included. Treatment consisted of endoscopic mucosal resection in 19 cases, and cap aspiration in 13 cases...
August 5, 2016: Endoscopy
https://www.readbyqxmd.com/read/27436165/variations-in-the-use-of-mhealth-tools-the-va-mobile-health-study
#9
Kathleen L Frisbee
BACKGROUND: Mobile health (mHealth) technologies exhibit promise for offering patients and their caregivers point-of-need tools for health self-management. This research study involved the dissemination of iPads containing a suite of mHealth apps to family caregivers of veterans who receive care from the Veterans Affairs (VA) Health Administration and have serious physical or mental injuries. OBJECTIVE: The goal of the study was to identify factors and characteristics of veterans and their family caregivers that predict the use of mHealth apps...
2016: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/27087699/a-q-modulation-technique-for-efficient-inductive-power-transmission
#10
Mehdi Kiani, Byunghun Lee, Pyungwoo Yeon, Maysam Ghovanloo
A fully-integrated power management ASIC for efficient inductive power transmission has been presented capable of automatic load transformation using a method, called Q-modulation. Q-modulation is an adaptive scheme that offers load matching against a wide range of loading (RL ) and coupling distance (d23 ) variations in inductive links to maintain high power transfer efficiency (PTE). It is suitable for inductive powering implantable microelectronic devices (IMDs), recharging mobile electronics, and electric vehicles...
December 2015: IEEE Journal of Solid-state Circuits
https://www.readbyqxmd.com/read/27015251/impact-of-out-of-pocket-costs-on-prescription-fills-among-new-initiators-of-biologic-therapies-for-rheumatoid-arthritis
#11
Sari Hopson, Kim Saverno, Larry Z Liu, Ahmad AL-Sabbagh, John Orazem, Mary E Costantino, Margaret K Pasquale
BACKGROUND: Biologic disease-modifying antirheumatic drug (DMARD) therapies are a mainstay of treatment for rheumatoid arthritis (RA), yet high member out-of-pocket (OOP) costs for such therapies may limit patient access to these therapies. OBJECTIVE: To understand whether there is a relationship between OOP costs and the initial fill and subsequent refills of biologic DMARD treatments for RA members. METHODS: Members of a national Medicare Advantage and Prescription Drug (MAPD) plan with an adjudicated (paid or reversed) claim for a biologic DMARD indicated for RA were identified from July 1, 2007, to December 31, 2012, and followed retrospectively...
February 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27015050/accepting-medication-therapy-management-recommendations-to-add-aceis-or-arbs-in-diabetes-care
#12
Jason T Hurwitz, Amy J Grizzle, Jill Augustine, Rick Rehfeld, Ann Wild, Ivo Abraham
BACKGROUND: National guidelines and initiatives have promoted the use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) for patients with diabetes. The University of Arizona Medication Management Center (UA-MMC) is contracted by Medicare health plans, pharmacy benefit managers (PBMs), and multiple commercial health insurance plans to provide medication therapy management (MTM) services for plan members. As part of the MTM program, recommendations have been made for those patients who may benefit from the addition of an ACEI/ARB...
January 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27008069/treatment-satisfaction-with-different-weight-loss-methods-among-respondents-with-obesity
#13
S Gupta, Z Wang
Satisfaction with weight loss (WL) methods has been correlated with the effectiveness, long-term compliance and commitment to weight management. This study explored treatment satisfaction associated with different WL methods among patients with obesity. Cross-sectional data were analysed from the 2012 US National Health and Wellness Survey. Respondents with obesity were categorized as having a WL procedure (e.g., gastric bypass and gastric banding) or using a prescription medication for WL (Sur/Rx), vs. using self-modification WL techniques (e...
April 2016: Clinical Obesity
https://www.readbyqxmd.com/read/26629289/successful-technical-and-clinical-outcome-using-a-second-generation-balloon-expandable-coronary-stent-for-transplant-renal-artery-stenosis-our-experience
#14
Jason Salsamendi, Keith Pereira, Reginald Baker, Shivank S Bhatia, Govindarajan Narayanan
Transplant renal artery stenosis (TRAS) is a vascular complication frequently seen because of increase in the number of renal transplantations. Early diagnosis and management is essential to optimize a proper graft function. Currently, the endovascular treatment of TRAS using angioplasty and/or stenting is considered the treatment of choice with the advantage that it does not preclude subsequent surgical correction. Treatment of TRAS with the use of stents, particularly in tortuous transplant renal anatomy presents a unique challenge to an interventional radiologist...
October 2015: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/26604874/consumer-opinions-of-health-information-exchange-e-prescribing-and-personal-health-records
#15
Gary L Cochran, Lina Lander, Marsha Morien, Daniel E Lomelin, Jeri Brittin, Celeste Reker, Donald G Klepser
BACKGROUND: Consumer satisfaction is a crucial component of health information technology (HIT) utilization, as high satisfaction is expected to increase HIT utilization among providers and to allow consumers to become full participants in their own healthcare management. OBJECTIVE: The primary objective of this pilot study was to identify consumer perspectives on health information technologies including health information exchange (HIE), e-prescribing (e-Rx), and personal health records (PHRs)...
2015: Perspectives in Health Information Management
https://www.readbyqxmd.com/read/26519436/development-and-validation-of-the-rxdx-dementia-risk-index-to-predict-dementia-in-patients-with-type-2-diabetes-and-hypertension
#16
Hemalkumar B Mehta, Vinay Mehta, Chu-Lin Tsai, Hua Chen, Rajender R Aparasu, Michael L Johnson
BACKGROUND: Elderly patients with type 2 diabetes mellitus and hypertension are at high risk for developing dementia. In addition to comorbid disease conditions (Dx), prescription drugs (Rx) are important risk factors for dementia. OBJECTIVE: Develop and validate the RxDx-Dementia risk index by combining diagnosis and prescription information in a single risk index to predict incident dementia, and compare its performance with diagnosis-based Charlson comorbidity score (CCS) and prescription-based chronic disease score (CDS)...
2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/26469635/a-single-chip-full-duplex-high-speed-transceiver-for-multi-site-stimulating-and-recording-neural-implants
#17
S Abdollah Mirbozorgi, Hadi Bahrami, Mohamad Sawan, Leslie A Rusch, Benoit Gosselin
We present a novel, fully-integrated, low-power full-duplex transceiver (FDT) to support high-density and bidirectional neural interfacing applications (high-channel count stimulating and recording) with asymmetric data rates: higher rates are required for recording (uplink signals) than stimulation (downlink signals). The transmitter (TX) and receiver (RX) share a single antenna to reduce implant size and complexity. The TX uses impulse radio ultra-wide band (IR-UWB) based on an edge combining approach, and the RX uses a novel 2...
June 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/26375996/adverse-effects-of-common-drugs-dietary-supplements
#18
REVIEW
Todd Matthew Felix, Kelly Dowhower Karpa, Peter R Lewis
Dietary supplement-induced adverse effects often resolve quickly after discontinuation of the offending product, especially in younger patients. The potential for unwanted outcomes can be amplified in elderly patients or those taking multiple prescription drugs, especially where interactions exist with drugs metabolized by cytochrome P450 enzymes. Attributing injury or illness to a specific supplement can be challenging, especially in light of multi-ingredient products, product variability, and variability in reporting, as well as the vast underreporting of adverse drug reactions...
September 2015: FP Essentials
https://www.readbyqxmd.com/read/26350553/-clinical-audit-on-drug-prescriptions-for-elderly-patients-hospitalized-in-a-unit-of-psychiatry
#19
C Humaraut, J Caron, L Bayonne, Y Moalic
BACKGROUND: The elderly are particularly vulnerable to the iatrogenic effects of drugs that are a major public health problem. In a geriatric care unit of a psychiatric hospital, the pharmacist, in close cooperation with the various health professionals, takes part in the optimization of drug therapy of these patients during cross-professional consultation meetings. From 2009 to 2011, an evaluation of professional practices was run through a targeted clinical audit on the theme of "prescription drugs at the age of 75 and over"...
February 2016: L'Encéphale
https://www.readbyqxmd.com/read/26347971/loperamide-versus-psyllium-fiber-for-treatment-of-fecal-incontinence-the-fecal-incontinence-prescription-rx-management-firm-randomized-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Alayne D Markland, Kathryn L Burgio, William E Whitehead, Holly E Richter, C Mel Wilcox, David T Redden, Timothy M Beasley, Patricia S Goode
BACKGROUND: Fecal incontinence is a devastating condition with few US Food and Drug Administration-approved pharmacologic treatment options. Loperamide and psyllium, both first-line treatments, have different mechanisms of action without any comparative data. OBJECTIVE: The purpose of this study was to examine the effectiveness and tolerability of loperamide compared with psyllium for reducing fecal incontinence. We hypothesized that psyllium fiber supplementation would be more effective than loperamide for reducing fecal incontinence episodes and have fewer adverse effects...
October 2015: Diseases of the Colon and Rectum
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