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Bone marrow derived stem cells

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https://www.readbyqxmd.com/read/28088458/non-thermal-atmospheric-pressure-plasma-functionalized-dental-implant-for-enhancement-of-bacterial-resistance-and-osseointegration
#1
Jung-Hwan Lee, Won-Seok Jeong, Seog-Jin Seo, Hae-Won Kim, Kyoung-Nam Kim, Eun-Ha Choi, Kwang-Mahn Kim
OBJECTIVE: Even though roughened titanium (Ti) and Ti alloys have been clinically used as dental implant, they encourage bacterial adhesion, leading to failure of the initial stability. Here, the non-thermal atmospheric pressure plasma jet (NTAPPJ) functionalized Ti and Ti alloy were investigated to promote cellular activities but inhibit the initial attachment of the adherent pioneer bacterium, Streptococcus sanguinis, without topographical changes. METHODS: After the produced radicals from NTAPPJ were characterized, bacterial adhesion to specimens was assessed by PrestoBlue assay and live-dead staining with or without the NTAPPJ functionalizing...
January 11, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28087003/in%C3%A2-vitro-generation-of-renal-tubular-epithelial-cells-from-fibroblasts-implications-for-precision-and-regenerative-medicine-in-nephrology
#2
Christina M Wyatt, Nicole Dubois
Prior efforts to generate renal epithelial cells in vitro have relied on pluripotent or bone marrow-derived mesenchymal stem cells. A recent publication in Nature Cell Biology describes the generation of induced tubular epithelial cells from fibroblasts, potentially offering a novel platform for personalized drug toxicity screening and in vitro disease modeling. This report serves as a promising proof of principle study and opens future research directions, including the optimization of the reprogramming process, efficient translation to adult human fibroblasts, and the generation of highly specific functional renal cell types...
February 2017: Kidney International
https://www.readbyqxmd.com/read/28081346/neuroprotective-effects-of-bone-marrow-derived-mesenchymal-stem-cellsand-conditioned-medium-in-mechanically-injured-neuroblastoma-cells
#3
Mesut Mete, Işıl Aydemir, Ülkün Ünlü Ünsal, Yusuf Kurtuluş Duransoy, İbrahim Mehmet Tuğlu, Mehmet Selçuki
BACKGROUND/AIM: Bone marrow-derived mesenchymal stem cells (BMSCs) possess self-renewal characteristics that distinguish them from other cell types. Recent studies have focused on the effects of conditioned medium (CM) that includes the extracellular matrix. Here we examined the neuroprotective effects of BMSCs and CM on damaged neuroblastoma cells. MATERIALS AND METHODS: The cells were divided into five groups: 1) healthy controls, 2) damaged cells alone, 3) damaged cells treated with BMSCs, 4) damaged cells treated with CM, and 5) damaged cells treated with both BMSCs and CM...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28079980/induction-of-mesenchymal-stem-cell-differentiation-in-the-absence-of-soluble-inducer-for-cutaneous-wound-regeneration-by-a-chitin-nanofibers-based-hydrogel
#4
Kangquan Shou, Yao Huang, Baiwen Qi, Xiang Hu, Zhanjun Ma, Ang Lu, Chao Jian, Lina Zhang, Aixi Yu
Transplantation of bone marrow mesenchymal stem cells (BMSCs) has been considered as a promising strategy for wound healing. However, poor viability of engrafted BMSCs and limited capabilities of differentiation into the desired cell types in wounds often hinder their application. Few studies report the induction of BMSCs differentiation into the skin regeneration related cell types using natural biopolymer, e.g., chitin and its derivative. Here we utilized a chitin nanofibers(CNFs) hydrogel as a directive cue to induce BMSCs differentiation for enhancing cutaneous wound regeneration in the absence of cell-differentiating factors...
January 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28078807/traumatized-muscle-derived-multipotent-progenitor-cells-recruit-endothelial-cells-through-vascular-endothelial-growth-factor-a-action
#5
Heidi R H Supanc, Shannon Gorman, Rocky S Tuan
Traumatized muscle, such as that debrided from blast injury sites, is considered a promising and convenient tissue source for multipotent progenitor cells (MPCs), a population of adult mesenchymal stem cell (MSC)-like cells. The present study aimed to assess the regenerative therapeutic potential of human traumatized muscle-derived MPCs, e.g., for injury repair in the blast-traumatized extremity, by comparing their pro-angiogenic potential in vitro and capillary recruitment activity in vivo to those of MSCs isolated from human bone marrow, a widely-used tissue source...
January 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28077355/no-evidence-for-the-use-of-stem-cell-therapy-for-tendon-disorders-a-systematic-review
#6
Haiko I M F L Pas, Maarten H Moen, Hidde J Haisma, Marinus Winters
INTRODUCTION: Stem cells have emerged as a new treatment option for tendon disorders. We systematically reviewed the current evidence for stem cell therapy in tendon disorders. METHODS: Randomised and non-randomised controlled trials, cohort studies and case series with a minimum of 5 cases were searched in MEDLINE, CENTRAL, EMBASE, CINAHL, PEDro and SPORTDiscus. In addition, we searched grey literature databases and trial registers. Only human studies were included and no time or language restrictions were applied to our search...
January 11, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28071988/braided-and-stacked-electrospun-nanofibrous-scaffolds-for-tendon-and-ligament-tissue-engineering
#7
Benjamin B Rothrauff, Brian B Lauro, Guang Yang, Richard E Debski, Volker Musahl, Rocky Tuan
Tendon and ligament injuries are a persistent orthopaedic challenge given their poor innate healing capacity. Non-woven electrospun nanofibrous scaffolds composed of polyesters have been used to mimic the mechanics and topographical cues of native tendons and ligaments. However, non-woven nanofibers have several limitations that prevent broader clinical application, including poor cell infiltration as well as tensile and suture-retention strengths that are inferior to native tissues. In this study, multilayered scaffolds of aligned electrospun nanofibers of two designs - stacked or braided - were fabricated...
January 10, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28067873/cotransplantation-of-bone-marrow-derived-mesenchymal-stem-cells-in-haploidentical-hematopoietic-stem-cell-transplantation-in-patients-with-severe-aplastic-anemia-an-interim-summary-for-a-multicenter-phase-ii-trial-results
#8
Z Liu, Y Zhang, H Xiao, Z Yao, H Zhang, Q Liu, B Wu, D Nie, Y Li, Y Pang, Z Fan, L Li, Z Jiang, F Duan, H Li, P Zhang, Y Gao, L Ouyang, C Yue, M Xie, C Shi, Y Xiao, S Wang
Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for severe aplastic anemia (SAA) is mainly limited by the high incidence of graft failure and GvHD. Mesenchymal stem cells (MSCs) have been shown to support hematopoiesis in vivo and to display potent immunosuppressive effects to prevent or treat GvHD after HSCT. In a multicenter phase II trial, we developed an approach with co-transplantation of MSCs in patients undergoing haplo-HSCT. Forty-four patients with SAA were included. The conditioning regimen included busulfan, cyclophosphamide and thymoglobulin (ATG)...
January 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28067165/gene-therapy-in-fanconi-anemia-a-matter-of-time-safety-and-gene-transfer-tool-efficiency
#9
Verhoeyen Els, Francisco José Román Rodríguez, François-Loïc Cosset, Camille Lévy, Paula Rio
Fanconi anemia (FA) is a rare genetic syndrome characterized by progressive marrow failure. Gene therapy by infusion of FA-corrected autologous hematopoietic stem cells (HSCs) may offer a potential cure since it is a monogenetic disease with mutations in the FANC genes, coding for DNA repair enzymes (See review[1]). However, the collection of hCD34 +-cells in FA patients implies particular challenges because of the reduced numbers of progenitor cells present in their bone marrow (BM)[2] or mobilized peripheral blood[3-5]...
January 9, 2017: Current Gene Therapy
https://www.readbyqxmd.com/read/28064388/stem-cell-recipes-of-bone-marrow-and-fish-just-what-the-stroke-doctors-ordered
#10
REVIEW
Eleonora Napoli, Cesar V Borlongan
Stem cell therapy for stroke has advanced from the laboratory to the clinic, but remains as an experimental treatment. Two lines of transplant regimens have emerged, namely the "early bird" peripheral injections in subacute stroke patients and the "late night" direct intracerebral treatments in chronic stroke patients. Autologous bone marrow-derived stem cells, which only required minimal manipulations during graft cell preparation, gained fast-track entry into the clinic, while gene modified stem cells necessitated overcoming more stringent regulatory criteria before they were approved for clinical use...
January 7, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28062497/increased-proangiogenic-activity-of-mobilized-cd34-progenitor-cells-of-patients-with-acute-st-segment-elevation-myocardial-infarction-role-of-differential-micro-rna-378-expression
#11
Christian Templin, Julia Volkmann, Maximilian Y Emmert, Pavani Mocharla, Maja Müller, Nicolle Kraenkel, Jelena R Ghadri, Martin Meyer, Beata Styp-Rekowska, Sylvie Briand, Roland Klingenberg, Milosz Jaguszewski, Christian M Matter, Valentin Djonov, Francois Mach, Stephan Windecker, Simon P Hoerstrup, Thomas Thum, Thomas F Lüscher, Ulf Landmesser
OBJECTIVE: Proangiogenic effects of mobilized bone marrow-derived stem/progenitor cells are essential for cardiac repair after myocardial infarction. Micro-RNAs (miRNA/miR) are key regulators of angiogenesis. We investigated the differential regulation of angio-miRs, that is, miRNAs regulating neovascularization, in mobilized CD34(+) progenitor cells obtained from patients with an acute ST-segment-elevation myocardial infarction (STEMI) as compared with those with stable coronary artery disease or healthy subjects...
December 29, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28062362/induced-pluripotent-stem-cell-technology-a-window-for-studying-the-pathogenesis-of-acquired-aplastic-anemia-and-possible-applications
#12
REVIEW
Mahmoud Elbadry, J Luis Espinoza, Shinji Nakao
Recent progress in human induced pluripotent stem cells (iPSCs) has opened the door to better understand the biology of human diseases, especially in rare disorders, such as acquired aplastic anemia (AA), in which the target hematopoietic tissues are depleted. The advent of somatic cell reprogramming has presented new routes for generating hematopoietic stem cells (HSCs) from patient-derived iPSCs and their differentiation into hematopoietic lineages. The purpose of this review is to discuss the recent advances in iPSC research technology and its potential applications in disease modeling for understanding the pathogenesis of bone marrow failure syndrome (BMFS) and the potential clinical utility of iPSC-derived cells...
January 3, 2017: Experimental Hematology
https://www.readbyqxmd.com/read/28061861/oxidative-status-predicts-quality-in-human-mesenchymal-stem-cells
#13
Alessandro Bertolo, Simona Capossela, Gion Fränkl, Martin Baur, Tobias Pötzel, Jivko Stoyanov
BACKGROUND: Human bone marrow-derived mesenchymal stem cells (MSC) are adult progenitor cells with great potential for application in cell-based therapies. From a cell-based therapy perspective, there are two limitations to MSC use: (1) these therapies require large numbers of cells, and long-term expansion of MSC in vitro promotes replicative senescence; and (2) patient variability is a challenge for defining MSC quality standards for transplantation. This study aimed to determine whether low or high oxidative status of MSC correlate with changes in cell expansion and differentiation potentials...
January 6, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28057159/-the-effect-and-mechanism-investigation-of-intermedin-on-the-apoptosis-of-bone-marrow-derived-mesenchymal-stem-cells-induced-by-hydrogen-peroxide
#14
D M Wang, J Li, W M Chen, X P Long, B Shi, R Z Zhao
Objective: To investigate the effect and mechanism of intermedin (IMD)on the apoptosis of BMSCs induced by H2O2 and its mechanism. Methods: BMSCs being cultured in vitro. After 30 min pretreatment with 10(-6)mol/L IMD, cells were cultured in presence of 100 μmol/L H2O2 for 2 hour, cell apoptosis was determined by flow cytometry; Apoptosis related protein expression was determined by Western blotting and immunofluorescence; Protein and phosphorylation of ERK1/2 was detected by Western blotting and observe the influence of IMD after pretreatment with inhibitor of ERK1/2...
December 27, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28056498/bone-marrow-stem-cell-therapy-partially-ameliorates-pathological-consequences-in-livers-of-mice-expressing-mutant-human-%C3%AE-1-antitrypsin
#15
Prakash Baligar, Veena Kochat, Shailendra K Arindkar, Zaffar Equbal, Snehashish Mukherjee, Swati Patel, Perumal Nagarajan, Sujata Mohanty, Jeffrey H Teckman, Asok Mukhopadhyay
: Alpha1-antitrypsin deficiency (AATD) is a genetic disease, caused by mutation of the AAT gene. Accumulation of mutated AAT protein aggregates in hepatocytes leads to endoplasmic reticulum (ER) stress resulting in impairment of liver functions and in some cases hepatocellular carcinoma, whereas decline of AAT levels in sera is responsible for pulmonary emphysema. In critical cases of liver ailments, the only option for treatment is liver transplantation, whereas AAT replacement therapy is followed in case of emphysema...
January 5, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28054934/evaluation-of-the-potential-of-chitosan-%C3%AE-1-3-glucan-ha-material-as-scaffold-for-living-bone-graft-production-i-in-vitro-i-by-comparison-of-adsc-and-bmdsc-behaviour-on-its-surface
#16
Agata Przekora, Marta Vandrovcova, Martina Travnickova, Julia Pajorova, Martin Molitor, Grazyna Ginalska, Lucie Bacakova
The opinion regarding the origin of adult stem cells that should be used for living bone construct generation is strongly divided in the scientific community. In this study, the potential of chitosan/β-1,3-glucan/HA material as scaffold for bone regeneration applications was evaluated by behaviour comparison of adult stem cells derived from both origins - adipose tissue (ADSCs) and bone marrow (BMDSCs). In the case of ADSC isolation, low and high negative pressures were applied during liposuction procedure in order to determine if negative pressure settings may have impact on subsequent cell behaviour <i>in vitro</i>...
January 5, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28054239/the-protein-content-of-extracellular-vesicles-derived-from-expanded-human-umbilical-cord-blood-derived-cd133-and-human-bone-marrow-derived-mesenchymal-stem-cells-partially-explains-why-both-sources-are-advantageous-for-regenerative-medicine
#17
Addeli B B Angulski, Luiz G Capriglione, Michel Batista, Bruna H Marcon, Alexandra C Senegaglia, Marco A Stimamiglio, Alejandro Correa
Adult stem cells have beneficial effects when exposed to damaged tissue due, at least in part, to their paracrine activity, which includes soluble factors and extracellular vesicles (EVs). Given the multiplicity of signals carried by these vesicles through the horizontal transfer of functional molecules, human mesenchymal stem cell (hMSCs) and CD133(+) cell-derived EVs have been tested in various disease models and shown to recover damaged tissues. In this study, we profiled the protein content of EVs derived from expanded human CD133(+) cells and bone marrow-derived hMSCs with the intention of better understanding the functions performed by these vesicles/cells and delineating the most appropriate use of each EV in future therapeutic procedures...
January 4, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28053317/jawbone-microenvironment-promotes-periodontium-regeneration-by-regulating-the-function-of-periodontal-ligament-stem-cells
#18
Bin Zhu, Wenjia Liu, Yihan Liu, Xicong Zhao, Hao Zhang, Zhuojing Luo, Yan Jin
During tooth development, the jawbone interacts with dental germ and provides the development microenvironment. Jawbone-derived mesenchymal stem cells (JBMSCs) maintain this microenvironment for root and periodontium development. However, the effect of the jawbone microenvironment on periodontium tissue regeneration is largely elusive. Our previous study showed that cell aggregates (CAs) of bone marrow mesenchymal stem cells promoted periodontium regeneration on the treated dentin scaffold. Here, we found that JBMSCs enhanced not only the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) but also their adhesion to titanium (Ti) material surface...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28052241/modeling-dynamics-and-function-of-bone-marrow-cells-in-mouse-liver-regeneration
#19
Elisa Pedone, Vlad-Aris Olteanu, Lucia Marucci, Maria Isabel Muñoz-Martin, Sameh A Youssef, Alain de Bruin, Maria Pia Cosma
In rodents and humans, the liver can efficiently restore its mass after hepatectomy. This is largely attributed to the proliferation and cell cycle re-entry of hepatocytes. On the other hand, bone marrow cells (BMCs) migrate into the liver after resection. Here, we find that a block of BMC recruitment into the liver severely impairs its regeneration after the surgery. Mobilized hematopoietic stem and progenitor cells (HSPCs) in the resected liver can fuse with hepatocytes, and the hybrids proliferate earlier than the hepatocytes...
January 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28051153/the-metastasis-suppressor-rarres3-as-an-endogenous-inhibitor-of-the-immunoproteasome-expression-in-breast-cancer-cells
#20
Alison M Anderson, Murugan Kalimutho, Sarah Harten, Devathri M Nanayakkara, Kum Kum Khanna, Mark A Ragan
In breast cancer metastasis, the dynamic continuum involving pro- and anti-inflammatory regulators can become compromised. Over 600 genes have been implicated in metastasis to bone, lung or brain but how these genes might contribute to perturbation of immune function is poorly understood. To gain insight, we adopted a gene co-expression network approach that draws on the functional parallels between naturally occurring bone marrow-derived mesenchymal stem cells (BM-MSCs) and cancer stem cells (CSCs). Our network analyses indicate a key role for metastasis suppressor RARRES3, including potential to regulate the immunoproteasome (IP), a specialized proteasome induced under inflammatory conditions...
January 4, 2017: Scientific Reports
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