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Bone marrow derived stem cells

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https://www.readbyqxmd.com/read/29031245/decrease-in-cavity-size-and-oligodendrocyte-cell-death-using-neurosphere-derived-oligodendrocyte-like-cells-in-spinal-cord-contusion-model
#1
Hojjat Allah Abbaszadeh, Taki Tiraihi, Yousef Sadeghi, Ali Reza Delshad, Majid Sadeghizadeh, Taher Taheri, Ali Noori-Zadeh
Background: Oligodendrocyte cell death is among the important features of spinal cord injury, which appears within 15 min and occurs intensely for 4 h after injury, in the rat spinal contusion model. Accordingly, the number of oligodendrocytes is progressively reduced within 24 h after injury. Administration of oligodendrocyte-like cells (OLCs) into the lesion area is one of the approaches to counterbalance this condition. Methods: Bone marrow stromal cells were transdifferentiated into neurospheres and then into neural stem cells and later were differentiated into OLCs using triiodothyronine and transplanted into the spinal cord contusion rats...
October 15, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29027762/fresh-noncultured-endothelial-progenitor-cells-improve-neonatal-lung-hyperoxia-induced-alveolar-injury
#2
Alexandra B Firsova, A Daniel Bird, Degu Abebe, Judy Ng, Richard Mollard, Timothy J Cole
Treatment of preterm human infants with high oxygen can result in disrupted lung alveolar and vascular development. Local or systemic administration of endothelial progenitor cells (EPCs) is reported to remedy such disruption in animal models. In this study, the effects of both fresh (enriched for KDR) and cultured bone marrow (BM)-derived cell populations with EPC characteristics were examined following hyperoxia in neonatal mouse lungs. Intraperitoneal injection of fresh EPCs into five-day-old mice treated with 90% oxygen resulted in full recovery of hyperoxia-induced alveolar disruption by 56 days of age...
October 13, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29025689/soho-state-of-the-art-update-and-next-questions-biology-and-treatment-of-myelodysplastic-syndromes
#3
REVIEW
David A Sallman, Tiffany N Tanaka, Alan List, Rafael Bejar
Myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid neoplasms characterized by clonal hematopoiesis leading to bone marrow dysplasia and cytopenias. Recently, significant advancements have been made in understanding the pathogenic mechanisms of this disease. In particular, how a wide array of somatic mutations can induce a common clinical phenotype has been investigated. Specifically, activation of innate immune signaling (i.e. myeloid derived suppressor cells) and the NLRP3 inflammasome in hematopoietic stem/progenitor cells play a central role in the biology of MDS, leading to pyroptotic cell death and clonal expansion...
October 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29024519/optimization-of-the-use-of-a-pharmaceutical-grade-xeno-free-medium-for-in-vitro-expansion-of-human-mesenchymal-stem-stromal-cells
#4
M Cimino, R M Gonçalves, E Bauman, M Barroso-Vilares, E Logarinho, C C Barrias, M C L Martins
Human bone marrow (BM)-derived mesenchymal stem/stromal cells (hMSCs) are considered promising therapeutic agents in the field of cell therapy and regenerative medicine, mainly due to their relative facility to be isolated, multi-differentiation potential and immunomodulatory role. However, their application in clinics requires a crucial step of in vitro expansion. Most of the protocols for hMSCs in vitro culture use foetal bovine serum (FBS) as medium supplement that, being from animal origin, presents several safety concerns and may initiate xenogeneic immune responses after cells transplantation...
October 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29024399/high-magnesium-prevents-matrix-vesicle-mediated-mineralization-in-human-bone-marrow-derived-mesenchymal-stem-cells-via-mitochondrial-pathway-and-autophagy
#5
Yaqiang Li, Jing Wang, Jiaji Yue, Yu Wang, Chunxi Yang, Quanjun Cui
Magnesium, as a physiological calcium antagonist, plays vital role in the bone metabolism and the balance between magnesium and calcium is crucial in bone physiology. We recently demonstrated that matrix mineralization in human bone marrow-derived mesenchymal stem cells (hBMSCs) can be suppressed by high Mg(2+) . However, a complete understanding of the mechanisms involved still remains to be elucidated. As mitochondrial calcium phosphate granules depletion manifests concurrently with the appearance of matrix vesicles (MVs) and autophagy are associated with matrix mineralization, we studied the effect of high extracellular Mg(2+) on these pathways...
October 10, 2017: Cell Biology International
https://www.readbyqxmd.com/read/29024236/mesenchymal-stromal-cell-derived-extracellular-vesicles-provide-long-term-survival-after-total-body-irradiation-without-additional-hematopoietic-stem-cell-support
#6
Jill-Sandra Schoefinius, Bärbel Brunswig-Spickenheier, Thomas Speiseder, Sabrina Krebs, Ursula Just, Claudia Lange
The therapeutic effect of mesenchymal stromal cells (MSC) in tissue regeneration is based mainly on the secretion of bioactive molecules. Here, we report that the radioprotective effect of mouse bone marrow derived MSC (mMSC) can be attributed to extracellular vesicles (EV) released from mMSC. The transplantation of mMSC-derived EV into lethally irradiated mice resulted in long-term survival but no improvement in short-term reconstitution of the recipients. Importantly, the radiation rescue was efficient without additional hematopoietic support...
October 11, 2017: Stem Cells
https://www.readbyqxmd.com/read/29023156/stem-cell-therapy-for-articular-cartilage-repair-review-of-the-entity-of-cell-populations-used-and-the-result-of-the-clinical-application-of-each-entity
#7
Yong-Beom Park, Chul-Won Ha, Ji Heon Rhim, Han-Jun Lee
BACKGROUND: Following successful preclinical studies, stem cell therapy is emerging as a candidate for the treatment of articular cartilage lesions. Because stem cell therapy for cartilage repair in humans is at an early phase, confusion and errors are found in the literature regarding use of the term stem cell therapy in this field. PURPOSE: To provide an overview of the outcomes of cartilage repair, elucidating the various cell populations used, and thus reduce confusion with regard to using the term stem cell therapy...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29022209/therapeutic-doses-of-doxorubicin-induce-premature-senescence-of-human-mesenchymal-stem-cells-derived-from-menstrual-blood-bone-marrow-and-adipose-tissue
#8
Irina Kozhukharova, Victoria Zemelko, Zoya Kovaleva, Larisa Alekseenko, Olga Lyublinskaya, Nikolay Nikolsky
Doxorubicin (Dox) is an effective anticancer drug with known activity against a wide spectrum of malignancies, hematologic malignancies in particular. Despite extensive clinical use, the mechanisms of its side effects and negative action on normal cells remain under study. The aim of this study was to investigate the effect of Dox on cultured human mesenchymal stem cells (MSCs) derived from menstrual blood (eMSCs), bone marrow (BMSCs) and adipose tissue (AMSCs). Dox treatment in high doses decreased the survival of MSCs in a dose-dependent manner...
October 11, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29021583/polydopamine-laced-biomimetic-material-stimulation-of-bone-marrow-derived-mesenchymal-stem-cells-to-promote-osteogenic-effects
#9
Dong Joon Lee, Yan-Ting Lee, Rui Zou, Renie Daniel, Ching-Chang Ko
A hydroxyapatite-collagen (HC) composite material can mimic composition and ultra-structures of natural bone and provide adequate bioactive material-tissue interactions. Incorporation of dopamine (DA) is one of keys in increasing the mechanical strength of the HC material to approaching that of cortical bone. In this study, the in vitro osteogenic effects of polydopamine-laced hydroxyapatite collagen calcium silicate (HCCS-PDA) were examined by culturing rat mesenchymal stem cells (rMSCs) on HCCS-PDA and HCCS coated plates...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29020045/human-amnion-derived-mesenchymal-stem-cells-promote-osteogenic-and-angiogenic-differentiation-of-human-adipose-derived-stem-cells
#10
Chunli Zhang, Lidong Yu, Songjian Liu, Yuli Wang
Tissue engineering using suitable mesenchymal stem cells (MSCs) shows great potential to regenerate bone defects. Our previous studies have indicated that human amnion-derived mesenchymal stem cells (HAMSCs) could promote the osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMSCs). Human adipose-derived stem cells (HASCs), obtained from adipose tissue in abundance, are capable of multi-lineage differentiation. In this study, the effects of HAMSCs on osteogenic and angiogenic differentiation of HASCs were systematically investigated...
2017: PloS One
https://www.readbyqxmd.com/read/29018992/tenocyte-proliferation-and-migration-promoted-by-rat-bone-marrow-mesenchymal-stem-cell-derived-conditioned-medium
#11
Qiufang Chen, Qingfei Liang, Weixia Zhuang, Jun Zhou, Bingyu Zhang, Pu Xu, Yang Ju, Yasuyuki Morita, Qing Luo, Guanbin Song
OBJECTIVES: To investigate the impact of secreted factors of rat bone marrow mesenchymal stem cells (MSCs) on the proliferation and migration of tenocytes and provide evidence for the development of MSC-based therapeutic methods of tendon injury. RESULTS: Rat bone marrow mesenchymal stem cell-derived conditioned medium (MSC-CM) promoted the proliferation of tenocytes within 24 h and decreased the percentage of tenocytes in G1 phase. MSC-CM activated the extracellular signal-regulated kinase1/2 (ERK1/2) signal molecules, while the ERK1/2 inhibitor PD98059 abrogated the MSC-CM-induced proliferation of tenocytes, decreased the fraction of tenocytes in the G1 phase and elevated p-ERK1/2 expression...
October 10, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/29018484/infrapatellar-fat-pad-stem-cells-from-developmental-biology-to-cell-therapy
#12
REVIEW
Ronaldo J F C do Amaral, Henrique V Almeida, Daniel J Kelly, Fergal J O'Brien, Cathal J Kearney
The ideal cell type to be used for cartilage therapy should possess a proven chondrogenic capacity, not cause donor-site morbidity, and should be readily expandable in culture without losing their phenotype. There are several cell sources being investigated to promote cartilage regeneration: mature articular chondrocytes, chondrocyte progenitors, and various stem cells. Most recently, stem cells isolated from joint tissue, such as chondrogenic stem/progenitors from cartilage itself, synovial fluid, synovial membrane, and infrapatellar fat pad (IFP) have gained great attention due to their increased chondrogenic capacity over the bone marrow and subcutaneous adipose-derived stem cells...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29018448/ifn-%C3%AE-stat1-inos-induces-myeloid-progenitors-to-acquire-immunosuppressive-activity
#13
Shu-Han Yang, Liang Li, Yu-Qing Xie, Yuan Yao, Cai-Yue Gao, Liang-Huan Liao, Hong-Di Ma, M Eric Gershwin, Zhe-Xiong Lian
Autoimmune diseases often induce dysregulated hematopoiesis with altered number and function of hematopoietic stem and progenitor cells (HSPCs). However, there are limited studies on the direct regulation of HSPCs on T cells, which are often detrimental to autoimmunity. Here, we found that in a murine model of Concanavalin A-induced autoimmune hepatitis, LSK (Lineage(-)Sca-1(+)c-Kit(+))-like cells accumulated in liver, spleen, and bone marrow (BM), which were myeloid progenitors (Lineage(-)Sca-1(-)c-Kit(+)) that upregulated Sca-1 expression upon T cell-derived IFN-γ stimulation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29017973/modulating-microfibrillar-alignment-and-growth-factor-stimulation-to-regulate-mesenchymal-stem-cell-differentiation
#14
Dinorath Olvera, Binulal N Sathy, Simon F Carroll, Daniel J Kelly
The ideal tissue engineering (TE) strategy for ligament regeneration should recapitulate the bone - calcified cartilage - fibrocartilage - soft tissue interface. Aligned electrospun-fibers have been shown to guide the deposition of a highly organized extracellular matrix (ECM) necessary for ligament TE. However, recapitulating the different tissues observed in the bone-ligament interface using such constructs remains a challenge. This study aimed to explore how fiber alignment and growth factor stimulation interact to regulate the chondrogenic and ligamentous differentiation of mesenchymal stem cells (MSCs)...
October 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29017608/autologous-mesenchymal-stem-cells-or-meniscal-cells-what-is-the-best-cell-source-for-regenerative-meniscus-treatment-in-an-early-osteoarthritis-situation
#15
Johannes Zellner, Girish Pattappa, Matthias Koch, Siegmund Lang, Johannes Weber, Christian G Pfeifer, Michael B Mueller, Richard Kujat, Michael Nerlich, Peter Angele
BACKGROUND: Treatment of meniscus tears within the avascular region represents a significant challenge, particularly in a situation of early osteoarthritis. Cell-based tissue engineering approaches have shown promising results. However, studies have not found a consensus on the appropriate autologous cell source in a clinical situation, specifically in a challenging degenerative environment. The present study sought to evaluate the appropriate cell source for autologous meniscal repair in a demanding setting of early osteoarthritis...
October 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29016843/mesenchymal-stem-cells-as-natural-bio-factories-for-exosomes-carrying-mir-124a-in-the-treatment-of-gliomas
#16
Frederick M Lang, Anwar Hossain, Joy Gumin, Eric N Momin, Yuzaburo Shimizu, Dan Ledbetter, Tal Shahar, Shinji Yamashita, Brittany Parker-Kerrigan, Juan Fueyo, Raymond Sawaya, Frederick F Lang
Background: MicroRNAs (miRs) are promising new therapeutics for glioblastoma. However, which miRs are most effective against glioblastomas and how these miRs should be delivered are major unanswered problems. Methods: To identify potent anti-glioma miRs, we selected eight miRs based on a literature search and screened them against a panel of glioma stem cell lines (GSCs), representing all TCGA-defined glioblastoma subtypes. To address delivery, we tested the hypothesis that ex vivo-cultured bone marrow-derived mesenchymal stem cells (MSCs) can package miRs into exosomes and that these engineered exosomes can systemically deliver antiglioma miRs to glioblastomas...
August 14, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28993845/-new-experimental-strategies-in-cartilage-surgery
#17
REVIEW
L Rackwitz, J C Reichert, O Pullig, U Nöth
BACKGROUND: Cell and growth factor based strategies bear great potential to support the healing processes in cartilage repair and the therapy of osteoarthritic joints. OBJECTIVES: The following review provides an overview of novel experimental strategies for the therapy of focal cartilage defects and osteoarthritis, with emphasis on cell and growth factor based approaches. MATERIALS AND METHODS: The authors summarize their own data regarding the intraarticular injection of stem cells to treat osteoarthritis of the knee and provide a synopsis of the available literature discussing the most significant publications...
October 9, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28990080/rapamycin-promotes-osteogenesis-under-inflammatory-conditions
#18
Xing Li, Bei Chang, Banchao Wang, Wenhuan Bu, Liang Zhao, Jie Liu, Lin Meng, Lu Wang, Ying Xin, Dandan Wang, Qi Tang, Changyu Zheng, Hongchen Sun
Chronic periodontitis, a common oral disease, usually results in irreversible bone resorption. Bone regeneration is a complex process between bone‑forming activity of osteoblasts and bone‑resorbing activity of osteoclasts, and still remains a challenge for physicians clinically. A previous study demonstrated that the mechanistic target of rapamycin signaling pathway is involved in osteogenic differentiation of mesenchymal stromal cells. Herein, whether rapamycin could be used to induce osteogenic differentiation of primary bone marrow‑derived mesenchymal stem cells (BMSCs) in vitro and promote new bone formation in vivo were evaluated...
October 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28989976/hematopoietic-stem-cell-derived-adipocytes-promote-tumor-growth-and-cancer-cell-migration
#19
Y Xiong, D L Russell, L T McDonald, L A Cowart, A C LaRue
Adipocytes, apart from their critical role as the energy storage depots, contribute to the composition of the tumor microenvironment. Our previous studies based on a single hematopoietic stem cell (HSC) transplantation model, have revealed a novel source of adipocytes from HSCs via monocyte/macrophage progenitors. Herein, we extend these studies to examine the role of HSC-derived adipocytes (HSC-Ad) in tumor progression. When cultured under adipogenic conditions, bone marrow-derived monocytic progenitors differentiated into adipocytes that accumulated oil droplets containing triglyceride...
2017: International Journal of Cancer Research and Molecular Mechanisms
https://www.readbyqxmd.com/read/28986619/-therapeutic-utilization-of-stem-cells-in-orthopedics
#20
C Chiari, S Walzer, D Stelzeneder, M Schreiner, R Windhager
Stem cells are becoming increasingly more important in the field of regenerative medicine. Adult mesenchymal stem cells (MSCs) are harvested predominantly from bone marrow or adipose tissue, are already being used in the clinical setting and have a low potential for side effects. In orthopedics, experience has been gained in the treatment of bone defects, non-unions, cartilage defects, osteoarthritis and tendon pathologies. The current data are derived from case studies and randomized controlled trials are missing; therefore, there are many open questions concerning the optimal cell source, number of cells, administration technique (e...
October 6, 2017: Der Orthopäde
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