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Bone marrow derived stem cells

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https://www.readbyqxmd.com/read/29656620/the-effect-of-recombinant-tyrosine-hydroxylase-expression-on-the-neurogenic-differentiation-potency-of-mesenchymal-stem-cells
#1
Gizem Turac, Gokhan Duruksu, Erdal Karaoz
OBJECTIVE: Tyrosine hydroxylase (TH) is a rate-limiting enzyme in dopamine synthesis, making the enhancement of its activity a target for ensuring sufficient dopamine levels. Rat bone marrow mesenchymal stem cells (rBM-MSCs) are known to synthesize TH after differentiating into neuronal cells through chemical induction, but the effect of its ectopic expression on these cells has not yet been determined. This study investigated the effects of ectopic recombinant TH expression on the stemness characteristics of rBM-MSCs...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29655841/lysosomal-acid-lipase-deficiency-allograft-recurrence-and-liver-failure-clinical-outcomes-of-18-liver-transplantation-patients
#2
REVIEW
Donna Lee Bernstein, Steven Lobritto, Alina Iuga, Helen Remotti, Thomas Schiano, Maria Isabel Fiel, Manisha Balwani
Lysosomal acid lipase deficiency (LAL-D) results in progressive microvesicular hepatosteatosis, fibrosis, cirrhosis, dyslipidemia, and vascular disease. Interventions available prior to enzyme replacement therapy development, including lipid lowering medications, splenectomy, hematopoietic stem cell and liver transplantation were unsuccessful at preventing multi-systemic disease progression, and were associated with significant morbidity and mortality. We report two sisters, diagnosed in infancy, who succumbed to LAL-D with accelerated disease progression following splenectomy and liver transplantation...
March 27, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29653141/dual-mechanism-of-type-vii-collagen-transfer-by-bone-marrow-mesenchymal-stem-cell-extracellular-vesicles-to-recessive-dystrophic-epidermolysis-bullosa-fibroblasts
#3
Jeffrey McBride, Luis Rodriguez-Menocal, Ambar Candanedo, Wellington Guzman, Marta Garcia-Contreras, Evangelos Badiavas
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe blistering disease resulting from a lack of type VII collagen production. Recent clinical trials have shown efficacy of bone marrow-derived mesenchymal stem cells (BM-MSCs) in the treatment of epidermolysis bullosa, including improved basement membrane restructuring and cutaneous wound healing. The mechanism as to how type VII collagen is transferred from donor stem cell to recipient RDEB cells has not been defined. Here, we submit the model that BM-MSC-derived extracellular vesicles serve at least two roles: 1) to help transport type VII collagen within the extracellular space; and 2) to feed RDEB fibroblasts with messenger RNA that codes for type VII collagen, resulting in COL7A1 translation and synthesis of type VII collagen alpha chain proteins by RDEB fibroblasts...
April 10, 2018: Biochimie
https://www.readbyqxmd.com/read/29652725/therapeutic-strategies-involving-uterine-stem-cells-in-reproductive-medicine
#4
Michael Simoni, Hugh S Taylor
PURPOSE OF REVIEW: The current review provides an update on recent advances in stem cell biology relevant to female reproduction. RECENT FINDINGS: Stem cells are undifferentiated cells that often serve as a reservoir of cells to regenerate tissue in settings or injury or cell loss. The endometrium has progenitor stem cells that can replace all of the endometrium during each menstrual cycle. In addition, multipotent endometrial cells replace these progenitor cells when depleted...
April 12, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29652595/stem-cells-for-skeletal-muscle-tissue-engineering
#5
Molly N Pantellic, Lisa Marie Larkin
Volumetric muscle loss (VML) is a debilitating condition wherein muscle loss overwhelms the body's normal physiological repair mechanism. VML is particularly common among military service members who have sustained war injuries. Because of the high social and medical cost associated with VML and suboptimal current surgical treatments, there is great interest in developing better VML therapies. Skeletal muscle tissue engineering (SMTE) is a promising alternative to traditional VML surgical treatments that use autogenic tissue grafts, and rather uses isolated stem cells with myogenic potential to generate de novo skeletal muscle tissues to treat VML...
March 14, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29650042/dental-pulp-stem-cells-used-to-deliver-the-anticancer-drug-paclitaxel
#6
Hamideh Salehi, Siham Al-Arag, Elodie Middendorp, Csilla Gergely, Frederic Cuisinier, Valerie Orti
BACKGROUND: Understanding stem cell behavior as a delivery tool in cancer therapy is essential for evaluating their future clinical potential. Previous in-vivo studies proved the use of mesenchymal stem cells (MSCs) for local delivery of the commonest anticancer drug, paclitaxel (PTX). Dental pulp is a relatively abundant noninvasive source of MSCs. We assess dental pulp stem cells (DPSCs), for the first time, as anticancer drug carriers. Confocal Raman microscopy is a unique tool to trace drug and cell viability without labeling...
April 12, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29650039/carbon-black-suppresses-the-osteogenesis-of-mesenchymal-stem-cells-the-role-of-mitochondria
#7
Yulai Shen, Lu Wu, Dongdong Qin, Yankai Xia, Zhu Zhou, Xuemei Zhang, Xin Wu
BACKGROUND: The rapid increase in carbon black poses threats to human health. We evaluated the effect of CB (Printex 90) on the osteogenesis of bone-marrow-derived mesenchymal stem cells (MSCs). Mitochondria play an important role in the osteogenesis of MSCs and are potential targets of nanomaterials, so we studied the role of mitochondria in the CB Printex 90-induced effects on osteogenesis. RESULTS: Low doses of Printex 90 (3 ng/mL and 30 ng/mL) that did not cause deleterious effects on MSCs' viability significantly inhibited osteogenesis of MSCs...
April 12, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29649413/neural-stem-cells-derived-directly-from-adipose-tissue
#8
Eric David Petersen, Jessica R Zenchak, Olivia V Lossia, Ute Hochgeschwender
Neural stem cells are characterized as self-renewing cell populations with the ability to differentiate into the multiple tissue types of the central nervous system. These cells can differentiate into mature neurons, astrocytes, and oligodendrocytes. This category of stem cells has been shown to be a promisingly effective treatment for neurodegenerative diseases and neuronal injury. Most treatment studies with neural stem cells in animal models use embryonic brain derived neural stem cells. This approach presents both ethical and feasibility issues for translation to human patients...
March 16, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29649410/sca1-lin-cd117-mouse-bone-marrow-derived-mesenchymal-stem-cells-regulate-immature-dendritic-cell-maturation-by-inhibiting-tlr4-irf8-signaling-via-the-notch-rbp-j-pathway
#9
Xingxia Liu, ShaoDa Ren, Chaozhuo Ge, Kai Cheng, Xiaojing Li, Robert Chunhua Zhao
Mesenchymal stem cells (MSCs) have a superior immunomodulatory capacity compared to other cells of the immune system, and they hold great promise for treating various immune disorders. However, their regulatory effects on the maturation of immature dendritic cells (imDCs) are not fully understood. Here, we show that Sca-1+Lin-CD117-MSCs restrain the LPS-stimulated maturation transition of imDCs co-cultured without exogenous cytokines. The Notch signaling pathway plays a critical role in the process by controlling IRF8 expression in an RBP-J-dependent manner...
March 13, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29643986/ajuba-receptor-mediates-the-internalization-of-tumor-secreted-grp78-into-macrophages-through-different-endocytosis-pathways
#10
Xiaoqin La, Lichao Zhang, Hanqing Li, Zhuoyu Li, Guisheng Song, Peng Yang, Yufei Yang
Glucose-regulated protein 78 (GRP78), an ER chaperone, is overexpressed in cancer cells. Solid tumor cells can secrete GRP78 that can promote tumor angiogenesis, differentiation of bone marrow-derived mesenchymal stem cells, tumor cell proliferation and polarization of tumor-associated macrophages. However, the mechanism by which GRP78 functions as a tumor promoter either by staying on the membrane to stimulate intracellular signals or directly entering into cytosolic remains unknown. Here, we reported that an endotoxin-free His-GRP78 protein was purified in vitro that simulates original secreted GRP78...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29642953/impact-of-bone-marrow-mesenchymal-stem-cell-immunomodulation-on-the-osteogenic-effects-of-laponite
#11
Tao Li, Zhong Long Liu, Ming Xiao, Ze Zheng Yang, Ming Zheng Peng, Cui Di Li, Xiao Jun Zhou, Jin Wu Wang
BACKGROUND: With the development of osteoimmunology and bone tissue engineering (BTE), it has been recognized that the immunomodulatory properties of bone biomaterials have considerable impact in determining their fate after implantation. In this regard, the polarization of macrophages secondary to biomaterials is postulated to play a crucial role in modulating their osteogenesis; thus, strategies that may facilitate this process engender increasing levels of attention. Whereas a variety of reports highlight the immunomodulation of bone marrow mesenchymal stem cells (BMSCs) in cell therapy or their osteogenesis in BTE, few have focused on the effect of BMSCs in promoting osteogenesis in BTE through regulating the phenotype of macrophages...
April 11, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29627514/combined-effects-of-photobiomodulation-and-alendronate-on-viability-of-osteoporotic-bone-marrow-derived-mesenchymal-stem-cells
#12
Somaye Fallahnezhad, Abdollah Amini, Behnam Hajihossainlou, Sufan Chien, Sara Dadras, Fatemehalsadat Rezaei, Mohammad Bayat
Osteoporotic bone marrow mesenchymal stem cells (BMMSCs) are involved in the pathogenesis of osteoporosis (OP). Photobiomodulation (PBM) has positive effects on healthy BMMSCs. The goal of current experiment was to evaluate the combined influence of photobiomodulation PBM and alendronate (ALN) incubation on ovariectomized induced osteoporosis(OVX)- BMMSC viability in vitro. 15 female adult Wistar rats were distributed into the 2 groups: (1) 3 healthy (sham)control rats, (2) 12 OVX- rats. All OVX rats underwent ovariectomy...
March 22, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29627440/cyclic-biaxial-tensile-strain-promotes-bone-marrow-derived-mesenchymal-stem-cells-to-differentiate-into-cardiomyocyte-like-cells-by-mirna-27a
#13
Chengjian Cao, Liang Li, Huiming Li, Xueling He, Wu Geng, Yu Xiaoqin
A physical stimuli, it has been reported that cyclic tensile strain can promote bone marrow-derived mesenchymal stem cells (BMSCs) to differentiate into cardiomyocytes, but the underlying mechanisms have been poorly elucidated so far. Here, we used a mimicking loading strain, cyclic biaxial tensile strain (CBTS), and found it can promote BMSCs to differentiate into cardiomyocytes. When the CBTS were loaded, the cells expressed cardiac-specific markers GATA4, TNNT2, MEF-2c, and Cx43, meanwhile we found miR-27a decreased and stem cell factor (SCF) increased...
April 5, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29626698/in-vitro-evaluation-of-mgsr-and-mgcasr-alloys-via-direct-culture-with-bone-marrow-derived-mesenchymal-stem-cells
#14
Wensen Jiang, Aaron F Cipriano, Qiaomu Tian, Chaoxing Zhang, Marisa Lopez, Amy Sallee, Alan Lin, Mayra Celene Cortez Alcaraz, Yuanhao Wu, Yufeng Zheng, Huinan Liu
Magnesium (Mg) and its alloys have been widely investigated as the most promising biodegradable metals to replace conventional non-degradable metals for temporary medical implant applications. New Mg alloys have been developed for medical applications in recent years; and the concept of alloying Mg with less-toxic elements have aroused tremendous interests due to the promise to address the problems associated with rapid degradation of Mg without compromising its cytocompatibility and biocompatibility. Of particular interests for orthopedic/spinal implant applications are the additions of calcium (Ca) and strontium (Sr) into Mg matrix because of their beneficial properties for bone regeneration...
April 4, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29625589/intramuscular-transplantation-of-bone-marrow-cells-prolongs-the-lifespan-of-sod1-g93a-mice-and-modulates-expression-of-prognosis-biomarkers-of-the-disease
#15
Amaya Rando, Diego Pastor, Mari Carmen Viso-León, Anna Martínez, Raquel Manzano, Xavier Navarro, Rosario Osta, Salvador Martínez
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive muscle weakness, paralysis and death. There is no effective treatment for ALS and stem cell therapy has arisen as a potential therapeutic approach. METHODS: SOD1 mutant mice were used to study the potential neurotrophic effect of bone marrow cells grafted into quadriceps femoris muscle. RESULTS: Bone marrow intramuscular transplants resulted in increased longevity with improved motor function and decreased motoneuron degeneration in the spinal cord...
April 6, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29623851/mesenchymal-stem-cells-derived-exosomes-a-possible-therapeutic-strategy-for-osteoporosis
#16
Yue Li, Daxiang Jin, Weixing Xie, Longfei Wen, Weijian Chen, Jixi Xu, Jinyong Ding, Dongcheng Ren, Zenglin Xiao
Osteoporosis is a common age-related disorder characterized by low bone mass and deterioration in bone microarchitecture, leading to increased skeletal fragility and fracture risk. The pathophysiology of osteoporosis is multifactorial. It is related to the imbalance between osteoblasts and osteoclasts; reduced bone mass and increased adipogenesis in the bone marrow. Moreover, angiogenesis, inflammatory process and miRNAs have shown effects in the formation of osteoporosis. In the recent years, mesenchymal stem cells (MSCs) have been regarded as an excellent choice for cell-based tissue engineering therapy of osteoporosis...
April 3, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29623216/feasibility-of-mesenchymal-stem-cell-culture-expansion-for-a-phase-i-clinical-trial-in-multiple-sclerosis
#17
Sarah M Planchon, Karen T Lingas, Jane Reese Koç, Brittney M Hooper, Basabi Maitra, Robert M Fox, Peter B Imrey, Kylie M Drake, Micheala A Aldred, Hillard M Lazarus, Jeffrey A Cohen
Background: Multiple sclerosis is an inflammatory, neurodegenerative disease of the central nervous system for which therapeutic mesenchymal stem cell transplantation is under study. Published experience of culture-expanding multiple sclerosis patients' mesenchymal stem cells for clinical trials is limited. Objective: To determine the feasibility of culture-expanding multiple sclerosis patients' mesenchymal stem cells for clinical use. Methods: In a phase I trial, autologous, bone marrow-derived mesenchymal stem cells were isolated from 25 trial participants with multiple sclerosis and eight matched controls, and culture-expanded to a target single dose of 1-2 × 106 cells/kg...
January 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29623134/generating-chondromimetic-mesenchymal-stem-cell-spheroids-by-regulating-media-composition-and-surface-coating
#18
BanuPriya Sridharan, Amy D Laflin, Michael S Detamore
INTRODUCTION: Spheroids of mesenchymal stem cells (MSCs) in cartilage tissue engineering have been shown to enhance regenerative potential owing to their 3D structure. In this study, we explored the possibility of priming spheroids under different media to replace the use of inductive surface coatings for chondrogenic differentiation. METHODS: Rat bone marrow-derived MSCs were organized into cell spheroids by the hanging drop technique and subsequently cultured on hyaluronic acid (HA) coated or non-coated well plates under different cell media conditions...
April 2018: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/29622661/isolation-of-a-multipotent-mesenchymal-stem-cell-like-population-from-human-adrenal-cortex
#19
Earn Gan, Wendy Robson, Peter Murphy, Robert Pickard, Simon Pearce, Rachel Oldershaw
BACKGROUND: The highly plastic nature of adrenal cortex suggests the presence of adrenocortical stem cells (ACSC) but the exact in vivo identity of ACSC remains elusive. A few studies have demonstrated the differentiation of adipose or bone marrow-derived mesenchymal stem cells (MSC) into steroid-producing cells. We therefore investigated the isolation of multipotent MSC from human adrenal cortex. METHODS: Human adrenals were obtained as discarded surgical material...
April 5, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29622473/impact-of-bone-marrow-derived-signals-on-nk-cell-development-and-functional-maturation
#20
REVIEW
Helena Stabile, Cinzia Fionda, Angela Santoni, Angela Gismondi
Natural killer (NK) cells are cytotoxic members of type I innate lymphocytes (ILC1) with a prominent role in anti-tumor and anti-viral immune responses. Despite the increasing insight into NK cell biology, the steps and stages leading to mature circulating NK cells require further investigation. Natural killer cell development and functional maturation are complex and multi-stage processes that occur predominantly in the bone marrow (BM) and originate from haematopoietic stem cells CD34+ (HSC). Within the BM, NK cell precursor (NKP) and NK cell development intermediates reside in specialized niches that are characterized by particular cellular components that provide signals required for their maturation...
March 27, 2018: Cytokine & Growth Factor Reviews
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