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https://www.readbyqxmd.com/read/28915716/implementation-and-utilization-of-the-molecular-tumor-board-to-guide-precision-medicine
#1
REVIEW
Shuko Harada, Rebecca Arend, Qian Dai, Jessica A Levesque, Thomas S Winokur, Rongjun Guo, Martin J Heslin, Lisle Nabell, L Burt Nabors, Nita A Limdi, Kevin A Roth, Edward E Partridge, Gene P Siegal, Eddy S Yang
BACKGROUND: With rapid advances in genomic medicine, the complexity of delivering precision medicine to oncology patients across a university health system demanded the creation of a Molecular Tumor Board (MTB) for patient selection and assessment of treatment options. The objective of this report is to analyze our progress to date and discuss the importance of the MTB in the implementation of personalized medicine. MATERIALS AND METHODS: Patients were reviewed in the MTB for appropriateness for comprehensive next generation sequencing (NGS) cancer gene set testing based on set criteria that were in place...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28893635/emendation-and-new-species-of-hapalorhynchus-stunkard-1922-digenea-schistosomatoidea-from-musk-turtles-kinosternidae-sternotherus-in-alabama-and-florida-rivers
#2
Jackson R Roberts, Kenneth M Halanych, Cova R Arias, Brian Folt, Jeffrey M Goessling, Stephen A Bullard
Hapalorhynchus Stunkard, 1922 is emended based on morphological study of existing museum specimens (type and voucher specimens) and newly-collected specimens infecting musk turtles (Testudines: Kinosternidae: Sternotherus spp.) from rivers in Alabama and Florida (USA). Hapalorhynchus conecuhensis n. sp. is described from an innominate musk turtle, Sternotherus cf. minor, (type host) from Blue Spring (31°5'27.64″N, 86°30'53.21″W; Pensacola Bay Basin, Alabama) and the loggerhead musk turtle, Sternotherus minor (Agassiz, 1857) from the Wacissa River (30°20'24...
September 8, 2017: Parasitology International
https://www.readbyqxmd.com/read/28886451/a-comparative-injury-severity-analysis-of-motorcycle-at-fault-crashes-on-rural-and-urban-roadways-in-alabama
#3
Samantha Islam, Joshua Brown
The research described in this paper explored the factors contributing to the injury severity resulting from the motorcycle at-fault accidents in rural and urban areas in Alabama. Given the occurrence of a motorcycle at-fault crash, random parameter logit models of injury severity (with possible outcomes of fatal, major, minor, and possible or no injury) were estimated. The estimated models identified a variety of statistically significant factors influencing the injury severities resulting from motorcycle at-fault crashes...
September 5, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28886414/serum-polychlorinated-biphenyls-and-leukocyte-telomere-length-in-a-highly-exposed-population-the-anniston-community-health-survey
#4
Catherine L Callahan, Marian Pavuk, Linda S Birnbaum, Xuefeng Ren, James R Olson, Matthew R Bonner
BACKGROUND: Serum polychlorinated biphenyls (PCBs) have previously been associated with longer leukocyte telomere length (LTL) in most, but not all, of the few previous studies. PCBs were produced in Anniston, Alabama from 1929 to 1971 and participants of the Anniston Community Health Survey (ACHS) were highly exposed. OBJECTIVES: We evaluated serum levels of 35 PCBs and relative telomere length in 559 ACHS participants. METHODS: Relative LTL was measured in DNA extracted from blood clots...
September 5, 2017: Environment International
https://www.readbyqxmd.com/read/28885270/association-between-internalized-hiv-related-stigma-and-hiv-care-visit-adherence
#5
Whitney S Rice, Kaylee Burnham, Michael J Mugavero, James L Raper, Ghislaine C Atkins, Bulent Turan
BACKGROUND: Internalized HIV-related stigma acts as a barrier to antiretroviral therapy (ART) adherence, but its effects on other HIV care continuum outcomes is unclear. METHODS: Among 196 HIV clinic patients in Birmingham, Alabama, we assessed internalized HIV-related stigma and depressive symptom severity using validated multi-item scales, and assessed ART adherence using a validated single-item measure. HIV visit adherence (attended out of total scheduled visits) was calculated using data from clinic records...
September 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28882276/economic-and-statistical-perspectives-on-traffic-safety-in-louisiana-2005-2015
#6
Onyumbe Enumbe B Lukongo
INTRODUCTION: This study examine and applies recent empirical evidence from Mississippi and Alabama on fatal crashes and its relationship with gasoline prices and alcohol consumptions using the Louisiana Crash Data Reports between January 2005 and December 2015. METHOD: The negative binomial models is the preferred specification for the Louisiana Crash Data. The marginal effects and related elasticities were calculated to facilitate the interpretation of the results...
September 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/28882073/qualitative-research-methods-to-advance-research-on-health-inequities-among-previously-incarcerated-women-living-with-hiv-in-alabama
#7
Courtenay Sprague, Michael L Scanlon, David W Pantalone
Justice-involved HIV-positive women have poor health outcomes that constitute health inequities. Researchers have yet to embrace the range of qualitative methods to elucidate how psychosocial histories are connected to pathways of vulnerability to HIV and incarceration for this key population. We used life course narratives and intersubjectivity-predicated on interview dialogue-to investigate how familial and social settings established their social patterning of HIV, incarceration risk, and poor health. Working with two Alabama community-based organizations, we recruited and interviewed 24 HIV-positive cisgender women with cyclical incarceration...
September 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28876296/neighborhood-health-care-access-and-sexually-transmitted-infections-among-women-in-the-southern-united-states-a-cross-sectional-multilevel-analysis
#8
Danielle F Haley, Andrew Edmonds, Nadya Belenky, DeMarc A Hickson, Catalina Ramirez, Gina M Wingood, Hector Bolivar, Elizabeth Golub, Adaora A Adimora
INTRODUCTION: The United States has experienced an increase in reportable sexually transmitted infections (STIs) while simultaneously experiencing a decline in safety net services for STI testing and treatment. This multilevel study assessed relationships between neighborhood-level access to health care and STIs among a predominantly Human Immunodeficiency Virus (HIV)-seropositive cohort of women living in the south. METHODS: This cross-sectional multilevel analysis included baseline data from HIV-seropositive and HIV-seronegative women enrolled in the Women's Interagency HIV Study sites in Alabama, Florida, Georgia, Mississippi, and North Carolina between 2013 and 2015 (N = 666)...
August 2, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28858939/beyond-abdominal-pain-pain-beliefs-pain-affect-and-distress-as-determinants-of-quality-of-life-in-patients-with-chronic-pancreatitis
#9
Craig E Keller, Charles Mel Wilcox, Gregory D Gudleski, Stacey Branham, Jeffrey M Lackner
GOALS: To assess the relationship between pain, psychological processes, and quality of life (QOL) in chronic pancreatitis (CP). BACKGROUND: CP is a progressive inflammatory disorder of the pancreas characteristically resulting in abdominal pain and impairing QOL. Pain due to CP is poorly understood and frequently difficult to treat. This pain has historically been understood as a peripheral process originating from the pancreas itself, but a growing body of literature is revealing an important role offered by central influences...
August 30, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28857935/post-deepwater-horizon-oil-spill-exposure-patterns-among-children-in-mobile-county-alabama
#10
Meghan Tipre, Anne Turner-Henson, Hemant K Tiwari, Julia Gohlke, Ligong Chen, Mark Leader, Nalini Sathiakumar
OBJECTIVE: The aim of this study was to characterize environmental exposure from Deepwater Horizon oil spill among pre-K to fourth-grade children from six schools in Mobile County, Alabama. METHODS: A mail-in survey administered 11 months post-oil spill to children's parents/caregivers elicited information on exposure-related activities. Descriptive and multivariable analyses were performed. RESULTS: Overall, 180 children (coastal schools, 90; inland schools, 90) completed the survey...
August 29, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28840797/flavobacterium-gossypii-sp-nov-isolated-from-the-root-tissue-of-field-grown-cotton
#11
Peter Kämpfer, Hans-Jürgen Busse, John A McInroy, Stefanie P Glaeser
A yellow-pigmented bacterial strain, JM-222T, isolated from the root tissue of field-grown cotton (Gossypium hirsutum) in Auburn, Alabama, USA, was studied for its taxonomic allocation. Cells of the isolate were rod-shaped and Gram-stain-negative. A blast analysis using the EzTaxon database showed that strain JM-222T shared highest 16S rRNA gene sequence similarity with the type strain of Flavobacterium endophyticum (98.9 %) followed by Flavobacterium qiangtangense (96.7 %). 16S rRNA gene sequence similarities to all other Flavobacterium species were below 95 %...
August 25, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28832880/association-of-vitamin-d-receptor-polymorphisms-with-the-risk-of-nonmelanoma-skin-cancer-in-adults
#12
Erin M Burns, Purushotham Guroji, Israr Ahmad, Hana M Nasr, Yingxue Wang, Iman A Tamimi, Elijah Stiefel, Mohammad S Abdelgawwad, Abdullah Shaheen, Anum F Muzaffar, Lisa M Bush, Christina B Hurst, Russell L Griffin, Craig A Elmets, Nabiha Yusuf
Importance: Protective effects of UV-B radiation against nonmelanoma skin cancer (NMSC) are exerted via signaling mechanisms involving the vitamin D receptor (VDR). Recent studies have examined single-nucleotide polymorphisms (SNPs) in the VDR, resulting in contradictory findings as to whether these polymorphisms increase a person's risk for NMSC. Objective: To examine whether the polymorphisms in the VDR gene are associated with the development of NMSC and the demographic characteristics of the participants...
August 23, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28829931/relationship-between-simulated-gap-wear-and-generalized-wear-of-resin-luting-cements
#13
A Tsujimoto, W W Barkmeier, T Takamizawa, M A Latta, M Miayazaki
OBJECTIVE: The relationship between the simulated gap wear and generalized wear of resin luting cements was investigated. METHODS: Five resin luting cements, G-Cem LinkForce (GL), Multilink Automix (MA), NX3 Nexus, Panavia V5 (PV), and RelyX Ultimate were evaluated and subsequently subjected to a wear challenge in a Leinfelder-Suzuki (Alabama) wear simulation device. Half of the specimens from each resin luting cement were photo-cured for 40 seconds and the other half were not photo-cured...
September 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28829530/the-social-construction-of-disasters-in-the-united-states-a-historical-and-cultural-phenomenon
#14
Tonya T Neaves, T Aaron Wachhaus, Grace A Royer
INTRODUCTION: Societal risks from hazards are continually increasing. Each year, disasters cause thousands of deaths and cost billions of dollars. In the first half of 2011, the United States endured countless disasters-winter snowstorms in the Midwest and Northeast; severe tornadic weather in the Mississippi, Alabama, and Missouri; flash flooding in Nashville; flooding along the Mississippi River; an earthquake on the East Coast, wildfires in Texas, and Hurricane Irene. Fundamental disaster planning is regarded as an interdisciplinary approach to develop strategies and instituting policies concerned with phases of emergency management; as such, its needs are predicated on the identification of hazards and assessment of risks...
May 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28822869/a-review-of-terrorism-and-its-reduction-of-the-gender-ratio-at-birth-after-seasonal-adjustment
#15
Victor Grech, Dorota Zammit
BACKGROUND: Males are born in excess of females, a ratio expressed as M/T (males:total births). The ratio exhibits seasonal variation. Furthermore, acute stressful events may result in a transient dip in male births due to excess foetal losses, reducing M/T. AIMS: This study was carried out in order to identify significant M/T dips after adjusting for seasonality. STUDY DESIGN: Live births by gender and month were sought for acute stressful events...
August 17, 2017: Early Human Development
https://www.readbyqxmd.com/read/28818890/complete-genome-sequences-of-mumps-and-measles-virus-isolates-from-three-states-in-the-united-states
#16
Laura C Magaña, Alex Espinosa, Rachel L Marine, Terry Fei Fan Ng, Christina J Castro, Anna M Montmayeur, Jill K Hacker, Samantha Scott, Thomas Whyte, Bettina Bankamp, M Steven Oberste, Paul A Rota
We report here the full coding sequence of nine paramyxovirus genomes, including two full-length mumps virus genomes (genotypes G and H) and seven measles virus genomes (genotypes B3 and D4, D8, and D9), from respiratory samples of patients from California, Virginia, and Alabama obtained between 2010 and 2014.
August 17, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28818732/family-factors-and-parenting-in-ukraine
#17
Viktor Burlaka, Sandra A Graham-Bermann, Jorge Delva
The present study aimed to estimate the use of positive and negative parenting practices in Ukraine and explore relationships between parenting practices, intimate partner violence (IPV), alcohol use, and sociodemographics. Parents of children (N=320) ages 9-16 from three Ukrainian regions answered questions from the Alabama Parenting Questionnaire (APQ), the Revised Conflict Tactics Scales (CTS-R), Family Adaptability and Cohesion Evaluation Scale (FACES), and the Alcohol Use Section of the Drinking and Drug History and Current Use Patterns questionnaire...
August 14, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28817433/class-wide-access-to-a-commercial-step-1-question-bank-during-preclinical-organ-based-modules-a-pilot-project
#18
James H Baños, Mark E Pepin, Nicholas Van Wagoner
PURPOSE: The authors examined the usefulness of a commercially available Step 1 question bank as a formative academic support tool throughout organ-based modules in an integrated preclinical medical curriculum. The authors also determined the extent to which correlation between question bank utilization and academic metrics varied with Medical College Admission Test (MCAT) scores. METHOD: In 2015, a cohort of 185 first-year medical students at University of Alabama School of Medicine were provided with 18-month full access to a commercially available Step 1 question bank of over 2,100 items throughout organ-based modules, although there were no requirements for use...
August 16, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28797652/geographic-variation-in-opioid-and-heroin-involved-drug-poisoning-mortality-rates
#19
Christopher J Ruhm
INTRODUCTION: An important barrier to formulating effective policies to address the rapid rise in U.S. fatal overdoses is that the specific drugs involved are frequently not identified on death certificates. This analysis supplies improved estimates of state opioid and heroin involved drug fatality rates in 2014, and changes from 2008 to 2014. METHODS: Reported mortality rates were calculated directly from death certificates and compared to corrected rates that imputed drug involvement when no drug was specified...
August 1, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28793136/an-exploration-of-the-associations-among-hearing-loss-physical-health-and-visual-memory-in-adults-from-west-central-alabama
#20
Marcia J Hay-McCutcheon, Adriana Hyams, Xin Yang, Jason Parton, Brianna Panasiuk, Sarah Ondocsin, Mary Margaret James, Forrest Scogin
Purpose: The purpose of this preliminary study was to explore the associations among hearing loss, physical health, and visual memory in adults living in rural areas, urban clusters, and an urban city in west Central Alabama. Method: Two hundred ninety-seven adults (182 women, 115 men) from rural areas, urban clusters, and an urban city of west Central Alabama completed a hearing assessment, a physical health questionnaire, a hearing handicap measure, and a visual memory test...
August 16, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
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