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Silicone and wounds

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https://www.readbyqxmd.com/read/28508517/on-demand-antimicrobial-treatment-with-antibiotic-loaded-porous-silicon-capped-with-a-ph-responsive-dual-plasma-polymer-barrier
#1
Roshan Bharath Vasani, Endre J Szili, Gayathri Rajeev, Nicolas Hans Voelcker
Chronic wounds are a major socio-economic problem. Bacterial infections in such wounds are a major contributor to lack of wound healing. An early indicator of wound infection is an increase in pH of the wound fluid. Herein, we describe the development of a pH-responsive drug delivery device that can potentially be used for wound decontamination in situ and on-demand in response to an increase in the pH of the wound environment. The device is based on a porous silicon film that provides a reservoir for encapsulation of an antibiotic within the pores...
May 16, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28494431/silica-nanoparticles-as-sources-of-silicic-acid-favoring-wound-healing-in-vitro
#2
Sandrine Quignard, Thibaud Coradin, Jonathan J Powell, Ravin Jugdaohsingh
There is good evidence that certain silicon-containing materials promote would healing and their common feature is the delivery of orthosilicic acid (Si(OH)4) either directly or following metabolism. In this respect, amorphous silica nanoparticles (NP), which dissolve in aqueous environments releasing up to 2mM orthosilicic acid, may be appropriate 'slow release' vehicles for bioactive silicon. Here we studied the impact of silica NP suspensions (primary particles∼10nm) in undersaturated conditions (below 2mM Si) with differing degrees of surface charge and dissolution rate on human dermal fibroblasts (CCD-25SK cells) viability, proliferation and migration in a cellular wound model...
April 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28492007/colchicine-may-assist-in-reducing-granulation-tissue-in-junctional-epidermolysis-bullosa
#3
Minhee Kim, Swaranjali Jain, Adam G Harris, Dedee F Murrell
Epidermolysis bullosa (EB) is a rare, inherited blistering genodermatosis. Patients with junctional EB (JEB) due to LAMB3 mutations have widespread blisters and erosions of skin, mucosae, and nails, creating significant physical, emotional, and psychosocial burdens. Here we report the use of colchicine for ameliorating hypergranulating wounds in a 41-year-old female with JEB generalized intermediate. Her skin wounds and granulation tissue gradually exacerbated under silicone dressings such that she became profoundly anemic...
June 2016: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28482540/dual-layered-3d-nanofibrous-matrix-incorporated-with-dual-drugs-and-their-synergetic-effect-on-accelerating-wound-healing-through-growth-factor-regulation
#4
Sivakumar Singaravelu, Giriprasath Ramanathan, Uma Tiruchirapalli Sivagnanam
The by-product of the slaughter house was utilized for the development of promising regenerative wound dressing material. Currently, dual-layered nanofibrous spongy scaffold was fabricated for tissue engineering applications. Herein, Keratin (K)-Fibrin (F)-Gelatin (G) 3D sponge loaded with Mupirocin (M) was fabricated with the naturally derived materials from bovine origin using freeze drying method. Moreover, poly(3-hydroxybutyric acid) (P) and Gelatin(G) solution loaded with Curcumin (C) were electrospun to get the dual drug loaded dual-layered nanofibrous spongy 3D scaffold (KFG:M-PG:C)...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28458983/s-shaped-wound-closure-technique-for-dumbbell-shaped-keloids
#5
Seiji Komatsu, Shougo Azumi, Yuko Hayashi, Tsuneharu Morito, Yoshihiro Kimata
Dog-ear collection, Z-plasty, and W-plasty are often performed for excision of dumbbell-shaped keloids; however, these procedures require additional incisions or excision of normal skin. Thus, an S-shaped wound closure technique was performed. The keloid lesions were extralesionally excised above the deep fascia, and the wound edges were shifted in opposite directions along the major axis to form an S-shape. The incision was closed by applying deep fascial sutures, subcutaneous sutures, and superficial sutures...
March 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28448714/octopus-inspired-assembly-of-nanosucker-arrays-for-dry-wet-adhesion
#6
Ying-Chu Chen, Hongta Yang
The octopus is capable of adhering to slippery, rough, and irregular surfaces in the marine intertidal zone because of its periodic infundibulum-shaped suckers on the arms. Here, we present a scalable self-assembly technology for fabricating adhesion materials that mimic octopus sucker functionality. By utilizing spin-coated two-dimensional colloidal crystals as templates, non-close-packed nanosucker arrays are patterned on silicone substrates. The resulting nanosuckers can be deformed to exhibit great adhesive capacities on both microrough and flat surfaces in dry and wet environments...
May 1, 2017: ACS Nano
https://www.readbyqxmd.com/read/28441071/efficacy-and-safety-of-23-gauge-pars-plana-vitrectomy-silicone-oil-tamponade-combination-for-treatment-of-pediatric-post-traumatic-endophthalmitis
#7
Wei Jin, Yaopeng Xu, Wenjun Wang, Yiqiao Xing, Anhuai Yang
PURPOSE: To determine (i) the etiology, epidemiology, mechanism of injury, and risk factors associated with open globe injuries (OGIs) in children and (ii) visual outcomes of pediatric patients with post-traumatic endophthalmitis following 23-gauge pars plana vitrectomy (PPV) combined with silicone oil tamponade (SOT). METHODS: A total of 107 consecutive patients, <15 years of age, who had been diagnosed with post-traumatic endophthalmitis between September 2009 and October 2015, were included in this 6-year retrospective study...
April 25, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28415441/stress-stiffened-silicon-nitride-micro-bridges-array-as-substrate-with-tunable-stiffness-for-cell-culture
#8
Jianfeng Chen, Guangli Liu, Chengfu Ma, Gang Zhao, Wenqiang Du, Wulin Zhu, Jiaru Chu
Recently, interactions between one-dimensional structural stiffness of physical micro environments and cell biological process have been widely studied. However in previous studies, the influence of structural stiffness on biological process was coupled with the influence of micro fiber curvature. Therefore decoupling the influences of fiber curvature and structural stiffness on cell biological process is of prime importance. In this study, we proposed a novel cell culture substrate comprised of silicon nitride bridges whose structure stiffness can be regulated by altering the axial residual stress without changing material and geometry properties...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28408096/local-treatment-of-a-pharyngocutaneous-fistula-secondary-to-osteoradionecrosis
#9
Olga González-Antolín
Radionecrosis is a late, and difficult to treat,complication of radiotherapy performed on head and neck tumours, and it is difficult to treat. This process causes significant damage, not only in the skin, but also in muscular, nervous, vascular, and bone structures. This, in turn, leads to airway and digestive tract involvement, as well as a functional loss and a cosmetic defect that usually requires reconstructive surgery. Therefore, this process is associated with a significant loss in the quality of life of patients and involves a long hospital stay for treatment, as well as the necessary support measures...
April 10, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/28383370/dual-force-vaginoplasty-for-treatment-of-segmental-vaginal-aplasia
#10
Ali M El Saman, Mohamad A Farag, Sherif A Shazly, Mohamed Noor, Mohammed K Ali, Essam R Othman, Mansour Khalifa, Tarek A Farghly, Dina A El Saman
BACKGROUND: Vaginal aplasia occurs in 1 in 5,000-10,000 female live births. In this report, we evaluated a novel dual-force vaginoplasty technique for treatment of 11 patients with segmental vaginal aplasia. TECHNIQUE: The principle of the approach is to thin the atretic part between two counteracting forces. The instrument was inserted laparoscopically into the proximal hematocolpos. Two balloon catheters, one for drainage and one for traction, were threaded over the inserter...
May 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28377320/do-il-3-gm-csf-effect-on-the-myofibroblastic-differentiation-of-human-adipose-derived-stromal-cells
#11
Jae-Sun Lee, Son-Seung Tae, Deok-Yeol Kim, Seung-Kyu Han, Woo-Kyung Kim, Eun-Sang Dhong
BACKGROUND: Capsular contracture is an incurable complication after silicone-based implant surgery. Myofibroblast is the predominant cell in the contracted capsule. We hypothesized that human adipose derive stromal cells (hASCs) together with fibroblast may show a similar phenotypic characteristics of myofibroblast after the treatment of inflammatory cytokines in vitro. MATERIALS AND METHODS: Interleukin 3 (IL-3) and granulocyte macrophage colony stimulating factor (GM-CSF) were treated in the culture of hASCs and HDFs...
April 2, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28347699/effect-of-adipose-derived-stem-cells-on-acellular-dermal-matrix-engraftment-in-a-rabbit-model-of-breast-reconstruction
#12
Ung Sik Jin, Ki Yong Hong, Young-Il Hwang
Acellular dermal matrix (ADM) is frequently used in implant-based breast reconstruction. Although there are several advantages, ADM implantation also increases the risk of certain complications. Recently, ADM seeded with adipose-derived stem cells (ADSCs) were shown to induce angiogenesis and improve wound healing. This study aimed to investigate the effects of ADSCs on ADM engraftment in a rabbit model of implant-based breast reconstruction. Silicone implants were inserted to submuscular pocket of 16 female New Zealand rabbits using ADM with or without seeding of fluorescent PKH26-labelled rabbit ADSCs...
June 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28326562/liposome-encapsulated-hemoglobin-accelerates-skin-wound-healing-in-diabetic-db-db-mice
#13
Tsuyoshi Fukui, Akira T Kawaguchi, Susumu Takekoshi, Muneo Miyasaka, Hideaki Sumiyoshi, Rica Tanaka
Since liposome-encapsulated hemoglobin with high O2 affinity (h-LEH, P50 O2  = 10 mm Hg) has been reported to accelerate skin wound healing in normal mice, it was tested in dB/dB mice with retarded wound healing, as seen in human diabetics. Two full-thickness dorsal wounds 6 mm in diameter encompassed by silicone stents were created in dB/dB mice. Two days later (day 2), the animals were randomly assigned to receive intravenous h-LEH (2 mL/kg, n = 7) or saline (2 mL/kg, n = 7). The same treatment was repeated 4 days after wounding (day 4), and the size of the skin lesions was analyzed by photography, surface perfusion was detected by Laser-Doppler imager, and plasma cytokines and chemokines were determined on days 0, 2, 4, and 7, when all animals were euthanized for morphological studies...
March 21, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28325530/in-vitro-measurements-of-burn-dressing-adherence-and-the-effect-of-interventions-on-reducing-adherence
#14
Michal Brichacek, Chenxi Ning, Justin P Gawaziuk, Song Liu, Sarvesh Logsetty
PURPOSE: There is a paucity of research on reducing dressing adherence. This is partly due to lack of an in vitro model, recreating the clinical variability of wounds. Previously we described an in vitro gelatin model to evaluate adherence in a standardized manner. We present evaluation of strategies to reduce adherence in six dressings. PROCEDURES: Dressing materials used were: PET (Control), fine mesh gauze coated in bismuth and petroleum jelly (BIS), nanocrystalline silver (NS), wide mesh polyester coated in polysporin ointment (WM), fine mesh cellulose acetate coated in polysporin ointment (FM), and soft silicone mesh (SIL)...
March 18, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28269987/a-simultaneously-antimicrobial-protein-repellent-and-cell-compatible-polyzwitterion-network
#15
Monika Kurowska, Alice Eickenscheidt, Diana-Lorena Guevara-Solarte, Vania Tanda Widyaya, Franziska Marx, Ali Al-Ahmad, Karen Lienkamp
A simultaneously antimicrobial, protein-repellent, and cell-compatible surface-attached polymer network is reported, which reduces the growth of bacterial biofilms on surfaces through its multifunctionality. The coating was made from a poly(oxonorbornene)-based zwitterion (PZI), which was surface-attached and cross-linked in one step by simultaneous UV-activated CH insertion and thiol-ene reaction. The process was applicable to both laboratory surfaces like silicon, glass, and gold and real-life surfaces like polyurethane foam wound dressings...
March 24, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28269276/toward-a-distributed-free-floating-wireless-implantable-neural-recording-system
#16
Pyungwoo Yeon, Xingyuan Tong, Byunghun Lee, Abdollah Mirbozorgi, Bruce Ash, Helmut Eckhardt, Maysam Ghovanloo
To understand the complex correlations between neural networks across different regions in the brain and their functions at high spatiotemporal resolution, a tool is needed for obtaining long-term single unit activity (SUA) across the entire brain area. The concept and preliminary design of a distributed free-floating wireless implantable neural recording (FF-WINeR) system are presented, which can enabling SUA acquisition by dispersedly implanting tens to hundreds of untethered 1 mm3 neural recording probes, floating with the brain and operating wirelessly across the cortical surface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227511/toward-a-distributed-free-floating-wireless-implantable-neural-recording-system
#17
Pyungwoo Yeon, Xingyuan Tong, Byunghun Lee, Abdollah Mirbozorgi, Bruce Ash, Helmut Eckhardt, Maysam Ghovanloo, Pyungwoo Yeon, Xingyuan Tong, Byunghun Lee, Abdollah Mirbozorgi, Bruce Ash, Helmut Eckhardt, Maysam Ghovanloo, Maysam Ghovanloo, Byunghun Lee, Bruce Ash, Xingyuan Tong, Pyungwoo Yeon, Abdollah Mirbozorgi, Helmut Eckhardt
To understand the complex correlations between neural networks across different regions in the brain and their functions at high spatiotemporal resolution, a tool is needed for obtaining long-term single unit activity (SUA) across the entire brain area. The concept and preliminary design of a distributed free-floating wireless implantable neural recording (FF-WINeR) system are presented, which can enabling SUA acquisition by dispersedly implanting tens to hundreds of untethered 1 mm(3) neural recording probes, floating with the brain and operating wirelessly across the cortical surface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28194352/application-of-a-silicone-sheet-in-negative-pressure-wound-therapy-to-treat-an-abdominal-wall-defect-after-necrotizing-fasciitis
#18
Jin Su Shin, Hwan Jun Choi
Necrotizing fasciitis (NF) is an aggressive soft-tissue infection involving the deep fascia and is characterized by extensive deterioration of the surrounding tissue. Immediate diagnosis and intensive treatment, including debridement and systemic antibiotics, represent the most important factors influencing the survival of NF patients. In this report, we present a case of NF in the abdomen due to an infection caused by a perforated small bowel after abdominal liposuction. It was successfully treated using negative-pressure wound therapy, in which a silicone sheet functioned as a barrier between the sponge and internal organs to protect the small bowel...
January 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28155844/enhanced-biocompatibility-of-neural-probes-by-integrating-microstructures-and-delivering-anti-inflammatory-agents-via-microfluidic-channels
#19
Bin Liu, Eric Kim, Anika Meggo, Sachin Gandhi, Hao Luo, Srinivas Kallakuri, Yong Xu, Jinsheng Zhang
OBJECTIVE: Biocompatibility is a major issue for chronic neural implants, involving inflammatory and wound healing responses of neurons and glial cells. To enhance biocompatibility, we developed silicon-parylene hybrid neural probes with open architecture electrodes, microfluidic channels and a reservoir for drug delivery to suppress tissue responses. APPROACH: We chronically implanted our neural probes in the rat auditory cortex and investigated (1) whether open architecture electrode reduces inflammatory reaction by measuring glial responses; and (2) whether delivery of antibiotic minocycline reduces inflammatory and tissue reaction...
April 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28129211/a-new-form-of-artificial-skin-to-promote-permanent-wound-coverage-a-preliminary-report
#20
Hsian-Jenn Wang, Lin-Gwei Wei, Chi-Hsien Wang, Ya-Chen Cheng, Junn-Liang Chang, Tai-Li Tsou, Chih-Hung Ku, Chun-Chang Li, Wen-Kuan Chiu, Chieh-Feng Chen
BACKGROUND: Although tendon-exposed or bone-exposed wounds can be resurfaced with flaps, such surgeries may not be feasible in patients with poor general or local conditions. Biosynthetic artificial skin is an alternative for critical wound coverage. We designed a new artificial skin bilayer to close difficult wounds permanently. AIM AND OBJECTIVES: This study compares incorporation and wound contraction between silicone acellular porcine dermis (SAPD) and the Integra graft (Integra Life Sciences Corp...
March 2017: Annals of Plastic Surgery
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