Ines Schoberleitner, Klaus Faserl, Christoph H Tripp, Elisabeth Judith Pechriggl, Stephan Sigl, Andrea Brunner, Bettina Zelger, Natascha Hermann-Kleiter, Leoni Baier, Theresia Steinkellner, Bettina Sarg, Daniel Egle, Christine Brunner, Dolores Wolfram
Excessive fibrous capsule formation around silicone mammary implants (SMI) involves immune reactions to silicone. Capsular fibrosis, a common SMI complication linked to host responses, worsens with specific implant topographies. Our study with 10 patients investigated intra- and inter-individually, reduced surface roughness effects on disease progression, wound responses, chronic inflammation, and capsular composition. The results illuminate the significant impact of surface roughness on acute inflammatory responses, fibrinogen accumulation, and the subsequent fibrotic cascade...
2024: Frontiers in Immunology