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Silicone and wounds

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https://www.readbyqxmd.com/read/27871930/reconstruction-of-penile-shaft-defects-following-the-silicone-injection-by-bipedicled-anterior-scrotal-flap
#1
Richard Fakin, Simon Zimmermann, Sirachai Jindarak, Nicole Lindenblatt, Pietro Giovanoli, Poonpissamai Suwajo
INTRODUCTION: Numerous causalities including attempts of penile augmentation with silicone or paraffin can lead to extensive circular penile shaft defects. Reconstruction is challenging and skin grafting is a suboptimal option, despite its widespread use. This paper presents a surgical technique for penile shaft reconstruction with bipedicled anterior scrotal flap. PATIENTS AND METHODS: Retrospective data analysis was performed for patients treated for symptomatic penile siliconomas who underwent subsequent penile reconstruction with bipedicled anterior scrotal flap between 2010 and 2015...
November 18, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27869355/delivery-of-flightless-i-neutralizing-antibody-from-porous-silicon-nanoparticles-improves-wound-healing-in-diabetic-mice
#2
Christopher T Turner, Steven J P McInnes, Elizabeth Melville, Allison J Cowin, Nicolas H Voelcker
Flightless I (Flii) is elevated in human chronic wounds and is a negative regulator of wound repair. Decreasing its activity improves healing responses. Flii neutralizing antibodies (FnAbs) decrease Flii activity in vivo and hold significant promise as healing agents. However, to avoid the need for repeated application in a clinical setting and to protect the therapeutic antibody from the hostile environment of the wound, suitable delivery vehicles are required. In this study, the use of porous silicon nanoparticles (pSi NPs) is demonstrated for the controlled release of FnAb to diabetic wounds...
November 21, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27820589/management-of-a-patient-with-toxic-epidermal-necrolysis-using-silicone-transfer-foam-dressings-and-a-secondary-absorbent-dressing
#3
Kimberly D McCarthy, Rachel M Donovan
BACKGROUND: Toxic epidermal necrolysis (TEN) is an exfoliative disorder of the skin usually caused by a drug reaction. The primary goal of wound care for patients with TEN is prevention of further mechanical trauma to the skin, along with management of wound infection. CASE: A 77-year-old woman with TEN was successfully managed with a perforated silver soft contact foam and a superabsorbent outer layer. Topical therapy combined nanoparticle silver for management of wound infection and minimized trauma to the skin as only the outer layer needed to be changed...
November 2016: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/27812471/toward-multiplexing-detection-of-wound-healing-biomarkers-on-porous-silicon-resonant-microcavities
#4
Fransiska Sri Herwahyu Krismastuti, Alex Cavallaro, Beatriz Prieto-Simon, Nicolas H Voelcker
Bacterial wound infections can cause septicemia and lead to limb amputation or death. Therefore, early detection of bacteria is important in chronic wound management. Here, an optical biosensor based on porous silicon resonant microcavity (pSiRM) structure modified with fluorogenic peptide substrate is demonstrated to detect the presence of Sortase A (SrtA), a bacterial enzyme found in the cell membrane protein of Staphylococcus aureus. The combination of fluorescence enhancement effects of the pSiRM architecture with the incorporation of SrtA fluorogenic peptide substrate within the pSi matrix enables the sensing of SrtA with an outstanding limit of detection of 8 × 10(-14) m...
June 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27798620/microrna-21-preserves-the-fibrotic-mechanical-memory-of-mesenchymal-stem-cells
#5
Chen Xi Li, Nilesh P Talele, Stellar Boo, Anne Koehler, Ericka Knee-Walden, Jenna L Balestrini, Pam Speight, Andras Kapus, Boris Hinz
Expansion on stiff culture substrates activates pro-fibrotic cell programs that are retained by mechanical memory. Here, we show that priming on physiologically soft silicone substrates suppresses fibrogenesis and desensitizes mesenchymal stem cells (MSCs) against subsequent mechanical activation in vitro and in vivo, and identify the microRNA miR-21 as a long-term memory keeper of the fibrogenic program in MSCs. During stiff priming, miR-21 levels were gradually increased by continued regulation through the acutely mechanosensitive myocardin-related transcription factor-A (MRTF-A/MLK-1) and remained high over 2 weeks after removal of the mechanical stimulus...
October 31, 2016: Nature Materials
https://www.readbyqxmd.com/read/27790732/root-coverage-using-porcine-collagen-matrix-with-fibroblast-growth-factor-2-a-pilot-study-in-dogs
#6
Jae Kook Cha, Yoo-Kyung Sun, Jung-Seok Lee, Seong-Ho Choi, Ui-Won Jung
AIM: The aim of this study was to evaluate the effect of fibroblast growth factor-2 (FGF-2) in combination with porcine collagen matrix (CM) for coverage of gingival recession defects in dogs. MATERIALS AND METHODS: In five male mongrel dogs, labial gingival recession defects were surgically created in the lower-third incisors bilaterally. The defects were randomly assigned to the CM/FGF-2 group (experimental) or the CM-only group (control). Standardised clinical photographs and silicone impressions were taken at 4 and 16 weeks of healing to calculate the remaining recession area...
October 28, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27767980/hemorheological-factors-can-be-informative-in-comparing-treatment-possibilities-of%C3%A2-abdominal-compartment-syndrome
#7
Norbert Nemeth, Katalin Peto, Adam Deak, Viktoria Sogor, Gabor Varga, Bence Tanczos, Klaudia Balog, Adrienn Csiszko, Zoltan Godo, Zsolt Szentkereszty
BACKGROUND: Abdominal compartment syndrome (ACS) is a life-threatening condition, of which pathomechanism hasn't been completely clarified, yet. Furthermore, surgical therapy still needs optimization. OBJECTIVE: We aimed to investigate microcirculatory and micro-rheological alterations in ACS, using various temporary abdominal closure methods, including three settings of vacuum-assisted closure technique (negative pressure wound therapy, NPWT). METHODS: On anesthetized pigs, by intraabdominally placed and filled-up silicone bags, intraabdominal pressure at 30 mmHg was maintained for 3 hours, and afterwards, decompressive laparotomy happened...
October 20, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27766402/management-of-implant-exposure-in-one-stage-breast-reconstruction-using-titanium-coated-polypropylene-mesh-sub-mammary-intercostal-perforator-flap
#8
Michele Antonio De Riggi, Nicola Rocco, Giulio Gherardini, Emanuela Esposito, Massimiliano D'Aiuto
INTRODUCTION: One-stage implant-based breast reconstruction using titanium-coated polypropylene mesh is a novel approach widely used in Europe. Complication rates in breast reconstruction with the use of titanium-coated meshes seem to be comparable to those in patients with implant-based breast reconstruction alone. However, the use of synthetic meshes in implant-based breast reconstructive surgery leads to new clinical scenarios with the need for the breast surgeon to face new complications...
December 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/27743199/arginine-silicate-inositol-complex-accelerates-cutaneous-wound-healing
#9
Ali Said Durmus, Mehmet Tuzcu, Oguzhan Ozdemir, Cemal Orhan, Nurhan Sahin, Ibrahim Hanifi Ozercan, James Richard Komorowski, Shakir Ali, Kazim Sahin
Arginine silicate inositol (ASI) complex is a composition of arginine, silicon, and inositol that has been shown to have beneficial effects on vascular health. This study reports the effects of an ASI ointment on wound healing in rats. A full-thickness excision wound was created by using a disposable 5 mm diameter skin punch biopsy tool. In this placebo-controlled study, the treatment group's wound areas were covered by 4 or 10 % ASI ointments twice a day for 5, 10, or 15 days. The rats were sacrificed either 5, 10, or 15 days after the wounds were created, and biopsy samples were taken for biochemical and histopathological analysis...
October 14, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27660818/electrochemically-modulated-nitric-oxide-release-from-flexible-silicone-rubber-patch-antimicrobial-activity-for-potential-wound-healing-applications
#10
Woong Hee Lee, Hang Ren, Jianfeng Wu, Ondrej Novak, Richard B Brown, Chuanwu Xi, Mark E Meyerhoff
Herein, we report a novel design and the antimicrobial efficacy of a flexible nitric oxide (NO) releasing patch for potential wound healing applications. The compact sized polydimethylsiloxane (PDMS) planar patch generates NO via electrochemical reduction of nitrite ions mediated by a copper(II)-ligand catalyst using a portable power system and an internal gold coated stainless steel mesh working electrode. Patches are fabricated via soft lithography and 3-D printing. The devices can continuously release NO over 4 days and exhibit potent bactericidal effects on both Escherichia coli and Staphylococcus aureus...
September 12, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/27626888/a-novel-skin-splint-for-accurately-mapping-dermal-remodeling-and-epithelialization-during-wound-healing
#11
Shiro Jimi, Francesco De Francesco, Giuseppe A Ferraro, Michele Riccio, Shuuji Hara
The mouse excisional dorsal full-thickness wound model with a silicon splint fixed on the skin has been widely used to mimic human wound healing. However, the method cannot accurately quantify dermal remodeling, since the initial point of epithelialization on the wound surface is unclear. To overcome this limitation, we have developed a novel mouse excisional wound model to assess the degree of epithelial extension and regeneration, using a plastic ring-shaped splint fixed beneath the surrounding epidermal tissue...
September 14, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27618292/keloids-current-therapies-in-barbados
#12
O J Nelson, J Ward, A L Forde, N Ojeh
Keloids are characterised by scar tissue overgrowth on the skin beyond the borders of the original wound following an abnormal wound healing process and tend not to regress. These disfiguring scars can cause pain, itching and inflammation for the patient leading to an emotional and psychological impact and a sub-standard quality of life. A variety of treatments using surgical and non-surgical approaches exists that have been reported to be beneficial. However, no one treatment currently stands out as the most optimal due to a number of factors including different keloid subtypes...
March 10, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/27586397/viscoelastic-physical-and-bio-degradable-properties-of-dermal-scaffolds-and-related-cell-behaviour
#13
Vaibhav Sharma, Nimesha Patel, Nupur Kohli, Nivedita Ravindran, Lilian Hook, Chris Mason, Elena García-Gareta
Dermal scaffolds promote healing of debilitating skin injuries caused by burns and chronic skin conditions. Currently available products present disadvantages and therefore, there is still a clinical need for developing new dermal substitutes. This study aimed at comparing the viscoelastic, physical and bio-degradable properties of two dermal scaffolds, the collagen-based and clinically well established Integra(®) and a novel fibrin-based dermal scaffold developed at our laboratory called Smart Matrix(®), to further evaluate our previous published findings that suggested a higher influx of cells, reduced wound contraction and less scarring for Smart Matrix(®) when used in vivo...
2016: Biomedical Materials
https://www.readbyqxmd.com/read/27574397/argus-ii-retinal-prosthesis-implantation-with-scleral-flap-and-autogenous-temporalis-fascia-as-alternative-patch-graft-material-a-4-year-follow-up
#14
Alexandre Matet, Nawel Amar, Saddek Mohand-Said, José-Alain Sahel, Pierre-Olivier Barale
INTRODUCTION: The Argus II retinal prosthesis is composed of an epiretinal electrode array positioned over the macula and connected to an extrascleral electronics case via a silicone cable, running through a sclerotomy. During implantation, the manufacturer recommends to cover the sclerotomy site with a patch of processed human pericardium to prevent postoperative hypotony and conjunctival erosion by the underlying electronics case. Due to biomedical regulations prohibiting the use of this material in France, we developed an alternative technique combining a scleral flap protecting the sclerotomy and an autogenous graft of superior temporalis fascia overlying the electronics case...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27556757/evidence-based-scar-management-how-to-improve-results-with-technique-and-technology
#15
Ibrahim Khansa, Bridget Harrison, Jeffrey E Janis
BACKGROUND: Scars represent the visible sequelae of trauma, injury, burn, or surgery. They may induce distress in the patient because of their aesthetically unpleasant appearance, especially if they are excessively raised, depressed, wide, or erythematous. They may also cause the patient symptoms of pain, tightness, and pruritus. Numerous products are marketed for scar prevention or improvement, but their efficacy is unclear. METHODS: A literature review of high-level studies analyzing methods to prevent or improve hypertrophic scars, keloids, and striae distensae was performed...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27531288/untoward-events-associated-with-aberrant-fluid-infusion-during-cataract-surgery-laboratory-study-with-corroborative-clinical%C3%A2-observations
#16
Richard S Koplin, David C Ritterband, Jack M Dodick, Eric D Donnenfeld, Mark Schafer
PURPOSE: To determine the relationship between untoward events noted during phacoemulsification surgery associated with aberrant infusion misdirection and their causal relationship to current infusion sleeve design. SETTING: The New York Eye & Ear Infirmary of Mt. Sinai, New York, New York, USA. DESIGN: Retrospective case reports and experimental study. METHODS: Observations of live cataract surgery were documented with high-definition videography using 3 commercial phacoemulsification platforms...
August 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27523658/clinical-acceptability-of-a-dressing-with-matrix-technology-a-multisite-evaluation-of-acute-and-chronic-wounds
#17
J Guthrie, R Potter
OBJECTIVE: This article will describe the findings of an evaluation on the performance and clinical acceptability of Urgotul Absorb Border (Urgo Medical), a silicone border adhesive foam dressing containing technology lipidocolloid (TLC) healing matrix technology, as either a primary or secondary dressing in the management of acute and chronic wounds in a multisite evaluation. The purpose of the evaluation was to establish the effectiveness of the silicone border dressing for managing exudate, ease of use, patient comfort and acceptability of the clinician for the dressing to meet with treatment objectives Method: The patient experiences given through verbal or written feedback were also documented...
August 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27508443/glycoprotein-ib-ix-v-complex-transmits-cytoskeletal-forces-that-enhance-platelet-adhesion
#18
Shirin Feghhi, Adam D Munday, Wes W Tooley, Shreya Rajsekar, Adriane M Fura, John D Kulman, Jose A López, Nathan J Sniadecki
Platelets bind to exposed vascular matrix at a wound site through a highly specialized surface receptor, glycoprotein (GP) Ib-IX-V complex, which recognizes von Willebrand factor (VWF) in the matrix. GPIb-IX-V is a catch bond for it becomes more stable as force is applied to it. After attaching to the wound site, platelets generate cytoskeletal forces to compact and reinforce the hemostatic plug. Here, we evaluated the role of the GPIb-IX-V complex in the transmission of cytoskeletal forces. We used arrays of flexible, silicone nanoposts to measure the contractility of individual platelets on VWF...
August 9, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27439772/airway-stenting-in-the-management-of-iatrogenic-tracheal-injuries-10-year-experience
#19
Rachid Tazi-Mezalek, Ali I Musani, Sophie Laroumagne, Philippe J Astoul, Xavier B D'Journo, Pascal A Thomas, Hervé Dutau
BACKGROUND AND OBJECTIVE: Iatrogenic tracheal injury (ITI) is a rare yet severe complication of endotracheal tube (ETT) placement or tracheostomy. ITI is suspected in patients with clinical and/or radiographic signs or inefficient mechanical ventilation (MV) following these procedures. Bronchoscopy is used to establish a definitive diagnosis. METHODS: We conducted a retrospective, single-centre chart review of 35 patients between 2004 and 2014. Depending on the nature and location of ITI and need for MV, patients were triaged to surgical repair, endoscopic management with airway stents or conservative treatment consisting of ETT or tracheotomy cannula (TC) placement distal to the wound and bronchoscopic surveillance...
November 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27368715/induction-of-delayed-wound-healing-by-irradiation-with-optional-mechanical-compression-in-swine
#20
Woonhyeok Jeong, Daemyung Oh, Sunyoung Kwon, Jinhee Kim, Daegu Son
A chronic wound or non-healing wound is one that fails to heal for at least 30 days after injury. This study was designed to create delayed wound healing induced by irradiation and mechanical compression using silicone block. Two female pigs received a single fraction of 20 Gy with 6-MeV electrons to a 22 × 60 cm field on the dorsal body skin 7 weeks before experimentation. A 30 × 30 mm sized wounds were created with preservation of muscle fascia on the dorsum. In groups of six, wounds were designated to be control (C) or test areas of irradiation only (T0), irradiation with silicone blocks for 1 week (T1), irradiation with silicone blocks for 2 weeks (T2), and irradiation with silicone blocks for 3 weeks (T3)...
June 16, 2016: Journal of Tissue Viability
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