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https://www.readbyqxmd.com/read/28736269/iodine-lithium-alpha-dextrin-il%C3%AE-d-against-staphylococcus-aureus-skin-infections-a-comparative-study-of-in-vitro-bactericidal-activity-and-cytotoxicity-between-il%C3%AE-d-and-povidone-iodine
#1
A P Zisi, M K Exindari, E K Siska, G G Koliakos
BACKGROUND: As antimicrobial resistance continuously increases, revisiting old antimicrobial agents, modified to enhance efficacy and safety, becomes important. Iodine has been widely used for more than 150 years as a wound and skin disinfectant; it is an effective broad range bactericide, and to date, it lacks reports of resistance development. The most important iodine-based agent is Povidone-Iodine (PVP-I) which provides excellent antibacterial activity. However, its safety profile has been questioned...
July 20, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28721095/chemotherapy-associated-paronychia-treated-with-2-povidone-iodine-a-series-of-cases
#2
Kara Capriotti, Joseph Capriotti, Jesse Pelletier, Kevin Stewart
BACKGROUND: Nail changes are known to occur during the use of chemotherapy for a variety of malignancies, particularly those treated with taxanes and EGFR inhibitors. There are currently no actively recruiting prospective clinical trials investigating potential treatments. There are also no US Food and Drug Administration-approved medical treatments for chemotherapy-associated paronychia and no consensus on the best way to treat these common chemotherapy-induced events. METHODS: A retrospective review of all cases presenting to a single dermatology private practice from June 2016 to January 2017 identified nine patients with chemotherapy-associated paronychia seeking treatment...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28713674/intraoperative-adjuncts-for-malignant-pleural-mesothelioma
#3
REVIEW
Warren Ho Chan, David J Sugarbaker, Bryan M Burt
Malignant pleural mesothelioma (MPM) is a rapidly fatal disease. Multimodality surgically based therapies may extend survival in select patients, however, local relapse after resection is common. Novel intraoperative adjunctive therapies including heated intraoperative chemotherapy (HIOC), heated intraoperative povidone-iodine (PVP-I), and photodynamic therapy (PDT) target micrometastatic disease and aim to improve local control. This review details the most recent studies and trials of HIOC, heated intraoperative PVP-I, and PDT, this aims to provide an update on some of the most promising intraoperative adjuncts for patients with MPM...
June 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28708223/author-s-reply-to-comments-to-povidone-iodine-3-minute-exposure-time-is-viable-in-preparation-for-cataract-surgery
#4
Chu L Nguyen, Lawrence J Oh, Eugene Wong, Ian C Francis
No abstract text is available yet for this article.
July 5, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28708220/comments-to-povidone-iodine-3-minute-exposure-time-is-viable-in-preparation-for-cataract-surgery
#5
Hiroyuki Shimada, Hiroyuki Nakashizuka, Andrzej Grzybowski
No abstract text is available yet for this article.
July 2, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28707872/povidone-iodine-based-polymeric-nanoparticles-for-antibacterial-applications
#6
Tianyi Gao, Hongbo Fan, Xinjie Wang, Yangyang Gao, Wenxin Liu, Wanjun Chen, Alideertu Dong, Yan-Jie Wang
As microbial contamination is becoming more and more serious, antibacterial agents play an important role in preventing and removing bacterial pathogens from microbial pollution in our daily life. To solve water solubility and antibacterial stability of PVP-I2 as a strong antibacterial agent, we successfully obtain hydrophobic povidone-iodine nanoparticles (povidone-iodine NPs) by a two-step method related to the advantage of nanotechnology. Firstly, the synthesis of poly(N-vinyl-2-pyrrolidone-co-methyl methacrylate) nanoparticles, i...
July 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28702414/an-observational-study-on-safety-and-efficacy-of-povidone-iodine-for-pleurodesis-in-cancer-patients
#7
Ayush Makkar, Sanjeev Patni, Anjum Khan Joad, Kamal Kishor Lakhera
INTRODUCTION: Pleurodesis is a time-honored procedure for malignant effusion as one of the palliative procedures to treat recurrent effusions. Various agents have been used in the past such as tetracycline, talc, bleomycin, and povidone-iodine. This paper aims at evaluating safety and efficacy of povidone-iodine for the procedure. MATERIALS AND METHODS: One hundred and four patients underwent of pleurodesis with povidone-iodine done at our center for malignant effusion between June 2008 and August 2015...
April 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28700086/antiseptics-for-burns
#8
REVIEW
Gill Norman, Janice Christie, Zhenmi Liu, Maggie J Westby, Jayne M Jefferies, Thomas Hudson, Jacky Edwards, Devi Prasad Mohapatra, Ibrahim A Hassan, Jo C Dumville
BACKGROUND: Burn wounds cause high levels of morbidity and mortality worldwide. People with burns are particularly vulnerable to infections; over 75% of all burn deaths (after initial resuscitation) result from infection. Antiseptics are topical agents that act to prevent growth of micro-organisms. A wide range are used with the intention of preventing infection and promoting healing of burn wounds. OBJECTIVES: To assess the effects and safety of antiseptics for the treatment of burns in any care setting...
July 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28698763/wolf-s-panniculitis
#9
Anastasiya Atanasova Chokoeva, Georgi Tchernev
A 28-year-old male patient, presented with a one-week history of pain and itching on the skin of the left upper leg. Erythematous indurated, warm and painful on palpation, subcutaneous plaques and nodules were clinically observed, affecting the skin of the left upper leg, within a recent black-wolf tattoo. The diagnosis of traumatic panniculitis with superposed bacterial infection, provoked by a wolf tattoo was made. The patient underwent 7-days systemic antibiotic treatment regimen and topical application of iodine povidone unguent under occlusion for 7 days...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28697892/bronchopleural-fistula-after-pneumonectomy-risk-factors-and-management-focusing-on-open-window-thoracostomy
#10
Antonio Mazzella, Alessandro Pardolesi, Patrick Maisonneuve, Francesco Petrella, Domenico Galetta, Roberto Gasparri, Lorenzo Spaggiari
OBJECTIVE: To evaluate principal risk factors and different therapeutic approaches for postpneumonectomy bronchopleural fistula (BPF), focusing on open window thoracostomy (OWT). METHODS: We retrospectively reviewed all patients treated by pneumonectomy for lung cancer between 1999 and 2014. We evaluated preoperative, operative, and postoperative data; interval between operation and fistula formation; and size, treatment, and predicting factors of BPF. Cumulative incidence curves for the development of BPF were drawn according to the Kaplan-Meier method...
June 12, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28697103/chlorhexidine-alcohol-compared-with-povidone-iodine-for-preoperative-topical-antisepsis-for-abdominal-hysterectomy
#11
Shitanshu Uppal, Ali Bazzi, R Kevin Reynolds, John Harris, Mark D Pearlman, Darrell A Campbell, Daniel M Morgan
OBJECTIVE: To compare preoperative chlorhexidine-alcohol topical antiseptic agent with povidone-iodine in patients undergoing abdominal hysterectomy for benign indications. METHODS: A retrospective cohort study of patients undergoing abdominal hysterectomy from July 2012 to February 2015 in the Michigan Surgical Quality Collaborative was performed. The primary exposure was the use of chlorhexidine-alcohol or povidone-iodine. The primary outcome was surgical site infection within 30 days...
July 7, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28690864/surgical-site-infections-after-cesarean-delivery-epidemiology-prevention-and-treatment
#12
REVIEW
Tetsuya Kawakita, Helain J Landy
Cesarean delivery (CD) is one of the most common procedures performed in the United States, accounting for 32% of all deliveries. Postpartum surgical site infection (SSI), wound infection and endometritis is a major cause of prolonged hospital stay and poses a burden to the health care system. SSIs complicate a significant number of patients who undergo CD - 2-7% will experience sound infections and 2-16% will develop endometritis. Many risk factors for SSI have been described. These include maternal factors (such as tobacco use; limited prenatal care; obesity; corticosteroid use; nulliparity; twin gestations; and previous CD), intrapartum and operative factors (such as chorioamnionitis; premature rupture of membranes; prolonged rupture of membranes; prolonged labor, particularly prolonged second stage; large incision length; subcutaneous tissue thickness > 3 cm; subcutaneous hematoma; lack of antibiotic prophylaxis; emergency delivery; and excessive blood loss), and obstetrical care on the teaching service of an academic institution...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/28689242/capsular-bag-irrigation-using-0-025-povidone-iodine-in-balanced-salt-solution-plus-for-the-treatment-of-postoperative-endophthalmitis
#13
Kyuen Otani, Hiroyuki Shimada, Hiroyuki Nakashizuka, Hirofumi Okubo
We examined the effectiveness and adverse events of using balanced salt solution (BSS) PLUS containing 0.025% povidone-iodine, a non-oculotoxic concentration, for capsular bag irrigation in a case of endophthalmitis mainly involving the anterior chamber. A 57-year-old female underwent cataract surgery and developed hypopyon on day 3 after surgery, with mainly anterior chamber inflammation. The capsular bag was irrigated with BSS PLUS containing 0.025% povidone-iodine. Gram-negative rods were detected from the anterior chamber fluid...
July 8, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28679179/safety-of-transrectal-ultrasound-guided-prostate-biopsy-in-patients-affected-by-crohn-s-disease
#14
Lucio Dell'Atti, Andrea Benedetto Galosi
PURPOSE: Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract. It is usually considered a contraindication to transrectal ultrasound-guided prostate biopsy (TRUSBx). The aim of this study was to investigate the safety of TRUSBx in a small cohort of patients with CD. METHODS: We queried our institutional database clinical data of patients with a diagnosis of CD undergoing TRUSBx, and a retrospective prospective study of 5 patients was planned...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28667230/efficacy-evaluation-of-an-anti-caries-varnish-protocol-for-a-phase-ii-randomised-controlled-trial
#15
Peter Milgrom, Ohnmar Tut, Marilynn Rothen, Lloyd Mancl, Marcelle Gallen, Jason M Tanzer
INTRODUCTION: Dental caries (tooth decay) is a common disease in which the products of sugar metabolism by certain bacteria that populate the tooth surface induce the development and progression of lesions (cavities). This is a phase II single-centre randomised, double-blind, active-controlled, parallel-group trial to assess the efficacy of a combination povidone iodine and sodium fluoride dental varnish to determine if it is superior to a varnish containing only sodium fluoride in the prevention of new caries lesions...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28666212/time-kill-kinetic-analysis-of-antimicrobial-chemotherapy-based-on-hydrogen-peroxide-photolysis-against-streptococcus-mutans-biofilm
#16
Midori Shirato, Keisuke Nakamura, Taro Kanno, Peter Lingström, Yoshimi Niwano, Ulf Örtengren
A recently developed antimicrobial technique utilizing hydroxyl radicals generated by hydrogen peroxide (H2O2) photolysis represents a promising new therapy for preventing and treating dental caries. The present study compared the antimicrobial time-kill kinetics of H2O2 photolysis, conventional antiseptics, and antimicrobial photodynamic therapy (aPDT) against biofilm-forming Streptococcus mutans (cariogenic bacteria) grown on hydroxyapatite disks. H2O2 photolysis was performed by irradiating the biofilm immersed in 3% H2O2 with 365-nm light-emitting diode (LED) light at an irradiance of 1000mW/cm(2) for up to 1...
June 21, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28664829/quantification-of-induced-hypothermia-from-aseptic-scrub-applications-during-rodent-surgery-preparation
#17
Anna M Skorupski, Jingyi Zhang, Danielle Ferguson, Frank Lawrence, F Claire Hankenson
Laboratory mice (Mus musculus) are prone to develop hypothermia during anesthesia for surgery, thus potentially impedinganesthetic recovery, wound healing, and future health. The core body temperatures of isoflurane-anesthetized mice areinfluenced by the choice of supplemental heat sources; however, the contribution of various surgical scrubs on the bodytemperatures of mice under gas anesthesia has not been assessed. We sought to quantify the effect of using alcohol (70%isopropyl alcohol [IPA]) compared with saline to rinse away surgical scrub on the progression of hypothermia in anesthetizedmice (n = 47)...
June 29, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28649064/formulation-and-dissolution-enhancement-of-meloxicam-tablets-using-polyvinyl-caprolactam-polyvinyl-acetate-polyethylene-glycol-graft-copolymer-and-povidone-in-combination
#18
Rabia Noor, S M Farid Hasan, Fouzia Hassan, Attique Rehman
Meloxicam is a poor water soluble drug mostly prescribed in various rheumatic diseases. The present research study was design to formulate and increase the solubility of meloxicam in the tablet dosage form. A 3(2) full factorial design was employed to optimize meloxicam formulations. Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (PVCL-PVA-PEG graft copolymer) and Povidone were taken as independent variables while cumulative drug release at 90 minutes was selected as dependent variable...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28648795/povidone-iodine-in-wound-healing-a-review-of-current-concepts-and-practices
#19
REVIEW
Paul Lorenz Bigliardi, Syed Abdul Latiff Alsagoff, Hossam Yehia El-Kafrawi, Jai-Kyong Pyon, Chad Tse Cheuk Wa, Martin Anthony Villa
BACKGROUND: Of the many antimicrobial agents available, iodophore-based formulations such as povidone iodine have remained popular after decades of use for antisepsis and wound healing applications due to their favorable efficacy and tolerability. Povidone iodine's broad spectrum of activity, ability to penetrate biofilms, lack of associated resistance, anti-inflammatory properties, low cytotoxicity and good tolerability have been cited as important factors, and no negative effect on wound healing has been observed in clinical practice...
June 23, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28643231/demodex-blepharitis-treated-with-a-novel-dilute-povidone-iodine-and-dmso-system-a-case-report
#20
Jesse S Pelletier, Kara Capriotti, Kevin S Stewart, Joseph A Capriotti
INTRODUCTION: Povidone-iodine aqueous solution is an antiseptic commonly used in ophthalmology for treatment of the ocular surface. Dimethylsulfoxide (DMSO) is a well-known skin penetration enhancer that is scarcely utilized in ophthalmic drug formulations. We describe here a low-dose formulation of 0.25% PVP-I in a gel containing DMSO for the treatment of Demodex blepharitis. CASE REPORT: A 95-year-old female presented with chronic blepharitis involving both the anterior and posterior eyelid margins...
June 22, 2017: Ophthalmology and Therapy
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