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https://www.readbyqxmd.com/read/28430323/povidone-iodine-3-minute-exposure-time-is-viable-in-preparation-for-cataract-surgery
#1
Chu Luan Nguyen, Lawrence J Oh, Eugene Wong, Ian C Francis
PURPOSE: Povidone-iodine (PI) is widely used to reduce the preoperative conjunctival bacterial load. This study aimed to evaluate the employment of PI 10% in an attempt to sterilize the ocular surface prior to cataract surgery, and to show that PI could be left in contact for 3 minutes. The viability of this exposure time in clinical practice, associated adverse events, and visual outcomes were documented. METHODS: In this prospective cohort study, phacoemulsification cataract surgery was performed in 604 patients by a single surgeon...
April 7, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28428640/transforming-growth-factor-%C3%AE-plays-an-important-role-in-enhancing-wound-healing-by-topical-application-of-povidone-iodine
#2
Li Wang, Wenhan Qin, Yaying Zhou, Bin Chen, Xiaoqing Zhao, Hailin Zhao, Emma Mi, Ella Mi, Qingmei Wang, Jiaolin Ning
Povidone-iodine (PVI) is principally used as an antimicrobial agent. It has been found that 0.5% PVI can attenuate congestion, edema and pain induced by pressure sores. Thus this study aimed to assess the effects of 0.5% PVI on acute skin wounds. Four full-thickness excisional wounds were generated on the dorsal skin of male Sprague-Dawley rats with a 10-mm sterile punch. Two wounds were left untreated and the other two were dressed with gauze with 0.5% PVI for 1 hour per day for the first 5 days after injury...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28410725/optimizing-the-antisepsis-protocol-effectiveness-of-3-povidone-iodine-1-0-applications-versus-a-single-application-of%C3%A2-povidone-iodine-5-0
#3
Megan R Silas, Richard M Schroeder, Richard B Thomson, William G Myers
PURPOSE: To determine the minimum effective concentration of povidone-iodine that reduces the bacterial load by 3-log10, the U.S. Food and Drug Administration requirement for antiseptic agents, and to study alternative dosing schedules of povidone-iodine to optimize its bactericidal effect. SETTING: Microbiology Laboratory, Evanston Hospital, Evanston, Illinois, USA. DESIGN: Experimental study. METHODS: A standard 0...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28405039/disinfection-of-laryngoscopes-a-survey-of-practice
#4
Vaishali Prabhakar Chaskar, Nandini Malay Dave, Raylene Dias, Priyanka Karnik
BACKGROUND AND AIMS: The laryngoscope is a common piece of equipment used by anaesthesiologists. It has been identified as a potential source of cross infection. Although guidelines exist regarding appropriate disinfection practices, recent reviews suggest ineffectiveness of current methods of disinfection and poor compliance with the established protocols. We conducted a questionnaire-based survey to study the current disinfection practices being followed by a cross section of anaesthesiologists...
March 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28401738/clinical-comparison-of-the-efficacy-of-three-different-bowel-preparation-methods-on-the-infectious-complications-following-transrectal-ultrasonography-guided-prostate-biopsy-in-nursing-practice
#5
Xin-Hong Zhang, Yong Jia, Wei-Hua Guo, Yu-Rong Ma, Jing Yang, Yu Zhang, Si-Chuan Hou, Chang-Cun Zhang
AIMS AND OBJECTIVES: To assess the effects of three different bowel preparation methods on the incidence of infectious complications in patients who underwent transrectal ultrasonography (TRUS) guided prostate biopsy. BACKGROUND: The standard bowel preparation protocol for prostate biopsy has not been established. DESIGN: A retrospective study in a single center. METHODS: From January 2013 to December 2015, the clinical records of 1130 patients who underwent prostate biopsy were respectively reviewed...
April 12, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28400958/in-vitro-evaluation-of-the-susceptibility-of-acinetobacter-baumannii-isolates-to-antiseptics-and-disinfectants-comparison-between-clinical-and-environmental-isolates
#6
Sanae Lanjri, Jean Uwingabiye, Mohammed Frikh, Lina Abdellatifi, Jalal Kasouati, Adil Maleb, Abdelouahed Bait, Abdelhay Lemnouer, Mostafa Elouennass
BACKGROUND: This study aims to assess the susceptibility of Acinetobacter baumannii isolates to the antiseptics and disinfectants commonly used, and to the non-approved product. METHODS: This is a prospective study carried out from February to August 2015, in the Bacteriology department of Mohammed V Military Teaching hospital of Rabat on A.baumannii isolates collected from colonized and/or infected patients and environmental samples. The antiseptics and disinfectants susceptibility testing was assessed using the micromethod validated in our department...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28387268/evidence-summary-the-relationship-between-oral-health-and-pulmonary-disease
#7
D Manger, M Walshaw, R Fitzgerald, J Doughty, K L Wanyonyi, S White, J E Gallagher
Introduction This paper is the second of four reviews exploring the relationships between oral health and general medical conditions, in order to support teams within Public Health England, health practitioners and policymakers.Aim This review aimed to explore the most contemporary evidence on whether poor oral health and pulmonary disease occurs in the same individuals or populations, to outline the nature of the relationship between these two health outcomes, and discuss the implication of any findings for health services and future research...
April 7, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28383375/comparison-of-vaginal-hysterectomy-techniques-and-interventions-for-benign-indications-a-systematic-review
#8
Peter C Jeppson, Sunil Balgobin, David D Rahn, Kristen A Matteson, Alexis A Dieter, David R Ellington, Sarit O Aschkenazi, Cara Grimes, Mamta M Mamik, Ethan M Balk, Miles Murphy
OBJECTIVE: To create evidence-based clinical practice guidelines based on a systematic review of published literature regarding the risks and benefits of available preoperative, intraoperative, and postoperative technical steps and interventions at the time of vaginal hysterectomy for benign indications. DATA SOURCES: We systematically searched the literature to identify studies that compared technical steps or interventions during the preoperative, intraoperative, and postoperative periods surrounding vaginal hysterectomy...
May 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28375620/self-association-of-rafoxanide-in-aqueous-media-and-its-application-in-preparing-amorphous-solid-dispersions
#9
Fan Meng, Tongzhou Liu, Elizabeth Schneider, Shehab Alzobaidi, Marco Gil, Feng Zhang
Our primary objective is to characterize the self-association of rafoxanide in alkaline media. The second objective is to illustrate the feasibility of using rafoxanide micellar solution as the feed solution to prepare amorphous solid dispersion via spray drying. Rafoxanide is a poorly water-soluble drug. It is a weak acid, and its poor aqueous solubility is due to its hydrophobicity. The surface-active property of rafoxanide has not been previously reported. It was discovered that the addition of a small percentage of organic solvents is required to elevate the solubility of rafoxanide above the critical micelle concentration to allow for the formation of micelles...
April 4, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28375119/physical-characterization-and-dissolution-performance-assessment-of-etravirine-solid-dispersions-prepared-by-spray-drying-process
#10
Pavan Kommavarapu, Arthanareeswari Maruthapillai, Kamaraj Palanisamy, Ravi Teja Koya
The aim of the current exertion was to prepare Solid Dispersion of Etravirine by Spray drying technique to enhance aqueous solubility and dissolution rate. Solid dispersions (SD) of Etravirine were prepared using Copovidone and Povidone-Copovidone in dichloromethane and physical properties were characterized by Scanning electron microscopy (SEM), X-Ray diffractometry (PXRD), Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC). SD's were evaluated for equilibrium solubility and in vitro drug release profile by dissolution testing...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28366652/transparent-ciprofloxacin-povidone-antibiotic-films-and-nanofiber-mats-as-potential-skin-and-wound-care-dressings
#11
Marco Contardi, José A Heredia-Guerrero, Giovanni Perotto, Paola Valentini, Pier Paolo Pompa, Raffaele Spanò, Luca Goldoni, Rosalia Bertorelli, Athanassia Athanassiou, Ilker S Bayer
Water insoluble monohydrochloride monohydrate free ciprofloxacin (Cipro) antibiotic was incorporated in polyvinylpyrrolidone (PVP) polymer matrix by using acetic acid co-solvent in water. The resultant solutions were cast into fully transparent antimicrobial films. Proper concentrations of acetic acid eliminated in situ crystallization of the antibiotic and the resultant phase separation upon solvent evaporation. The solutions could also be electrospun into nanofiber mats (non-transparent). Presence of residual PVP-bound acetic acid in dry PVP films induced unprecedented levels of plasticity (stretching capacity) and softness to the films...
March 31, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28365249/umbilical-cord-care-and-infection-rates-in-turkey
#12
Gülzade Uysal, Duygu Sönmez Düzkaya
OBJECTIVE: To compare the efficacy of umbilical cord sponging with 70% alcohol, sponging with 10% povidone-iodine, and dry care on the time to umbilical cord separation and bacterial colonization. DESIGN: Prospective, interventional experimental study design. SETTING: Three different family health centers in Istanbul, Turkey. PARTICIPANTS: In total, 194 newborns were enrolled in one of three study groups: Group 1, 70% alcohol (n = 67); Group 2, 10% povidone-iodine (n = 62); and Group 3, dry care (n = 65)...
March 29, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28361272/sterilization-of-blow-fly-eggs-chrysomya-megacephala-and-lucilia-cuprina-diptera-calliphoridae-for-maggot-debridement-therapy-application
#13
Kwankamol Limsopatham, Phadungkiat Khamnoi, Kabkaew L Sukontason, Dheerawan Boonyawan, Tarinee Chaiwong, Kom Sukontason
Maggot debridement therapy (MDT) is an application of sterile laboratory-reared blow fly larvae to remove necrotic tissue and disinfect wounds for medical conditions. For effective application, the blow fly larvae used in the wound treatment are required to be in aseptic condition. Here, we report the results of a detailed assessment of bacteria and fungi isolated from the eggs of two blow fly species, Chrysomya megacephala (F.) and Lucilia cuprina (Wiedemann) before and after sterilization by disinfectants Chlorhex-C, povidone-iodine, and sodium hypochlorite...
March 30, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28360968/molluscum-contagiosum-treated-with-dilute-povidone-iodine-a-series-of-cases
#14
Kara Capriotti, Kevin Stewart, Jesse Pelletier, Joseph Capriotti
Objective: To report our experience using a broad spectrum antimicrobial, povidone-iodine, as a novel at-home prescription treatment for molluscum contagiosum. Design/Setting: A systematic review of cases presenting to one of the author's private dermatology clinics from January to July of 2015 identified 12 patients with molluscum contagiosum seeking treatment. Participants: The population was pediatric, with six males and six female patients included (age range 2-17 years, mean age 6 years). Measurements: Patients were evaluated at baseline and returned to the office for evaluation at four-week intervals until resolution or failure to show for appointments, with number and location of lesions being recorded at each visit...
March 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28342227/treatment-of-adenoviral-keratoconjunctivitis-with-a-combination-of-povidone-iodine-1-0-and-dexamethasone-0-1-drops-a-clinical-prospective-controlled-randomized-study
#15
Natalya Kovalyuk, Igor Kaiserman, Michael Mimouni, Ornit Cohen, Shmuel Levartovsky, Hilda Sherbany, Michal Mandelboim
PURPOSE: To determine the efficacy of combination povidone-iodine (PVP-I) 1.0% eyedrops and dexamethasone 0.1% eyedrops in the treatment of adenoviral keratoconjunctivitis. MATERIALS AND METHODS: In a prospective, randomized, controlled, double-blinded clinical trial patients with recent adenoviral keratoconjunctivitis (diagnosed clinically and confirmed by PCR), we randomly divided into three treatment groups: study group - received PVP-I 1.0% and dexamethasone 0...
March 25, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28332593/injections-through-skin-colonized-with-staphylococcus-aureus-biofilm-introduce-contamination-despite-standard-antimicrobial-preparation-procedures
#16
Yi Wang, Valery Leng, Viraj Patel, K Scott Phillips
While surgical site preparation has been extensively studied, there is little information about resistance of skin microbiota in the biofilm form to antimicrobial decontamination, and there are no quantitative models to study how biofilm might be transferred into sterile tissue/implant materials during injections for joint spine and tendon, aspiration biopsies and dermal fillers (DF). In this work, we develop two in vitro models to simulate the process of skin preparation and DF injection using pig skin and SimSkin (silicone) materials, respectively...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28328726/clinical-outcomes-and-contact-lens-case-contamination-using-a-povidone-iodine-disinfection-system
#17
Jacqueline Tan, Ananya Datta, Katherine Wong, Mark D P Willcox, Ajay K Vijay
OBJECTIVE: To assess the incidence of adverse events during the use of a povidone-iodine disinfecting solution (cleadew) and the microbial contamination in contact lens cases. METHODS: A prospective, single-center, open-label, controlled study evaluating the use of cleadew cleaning and disinfecting system in existing daily wear soft contact lens wearers over a 3-month period was conducted. Ocular signs and symptoms during lens wear were assessed at baseline and after 1 and 3 months of using cleadew...
March 21, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28301615/topical-approaches-to-improve-surgical-outcomes-and-wound-healing-a-review-of-efficacy-and-safety
#18
Kristin Totoraitis, Joel L Cohen, Adam Friedman
<p>Surgical procedures are an important piece of a dermatologist's daily practice. Therefore, the optimization of post-surgical wound healing is an area of utmost importance and interest. Although low risk, one notable barrier to proper wound healing is surgical site infection.</p> <p>In an attempt to mitigate this risk and improve surgical outcomes, multiple topical products continue to be used both pre- and postprocedure. Traditionally, this includes both topical antibiotics and antiseptics...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28277997/effect-of-antiseptic-irrigation-on-infection-rates-of-traumatic-soft-tissue-wounds-a-longitudinal-cohort-study
#19
B Roth, R Neuenschwander, F Brill, F Wurmitzer, C Wegner, O Assadian, A Kramer
OBJECTIVE: Acute traumatic wounds are contaminated with bacteria and therefore an infection risk. Antiseptic wound irrigation before surgical intervention is routinely performed for contaminated wounds. However, a broad variety of different irrigation solutions are in use. The aim of this retrospective, non-randomised, controlled longitudinal cohort study was to assess the preventive effect of four different irrigation solutions before surgical treatment, on wound infection in traumatic soft tissue wounds...
March 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28272017/effects-of-hypericum-perforatum-on-an-experimentally-induced-diabetic-wound-in-a-rat-model
#20
Mehmet Farsak, Görkemo Özdağli, Doğay Özmüş, Ülkü Çömelekoğlu, Serap Yalın, Rabia Bozdoğan Arpacı, Ramazan Gen, Arzu Kanık, Derya Ümit Talas
OBJECTIVE: The aim of this study was to investigate the probable effects of Hypericum perforatum (HP) on wound healing in diabetic rats. MATERIALS AND METHODS: Thirty-five male Wistar rats were divided evenly into 5 groups. Diabetes formation was induced by intraperitoneal streptozotocin (60 mg/kg) administration for groups 1 (HP extract in olive oil), 2 (HP extract in ethanol), 3 (povidone-iodine application), and 4 (diabetic rats without any applied medication); group 5 was the control...
February 2017: Wounds: a Compendium of Clinical Research and Practice
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