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https://www.readbyqxmd.com/read/28643231/demodex-blepharitis-treated-with-a-novel-dilute-povidone-iodine-and-dmso-system-a-case-report
#1
Jesse S Pelletier, Kara Capriotti, Kevin S Stewart, Joseph A Capriotti
INTRODUCTION: Povidone-iodine aqueous solution is an antiseptic commonly used in ophthalmology for treatment of the ocular surface. Dimethylsulfoxide (DMSO) is a well-known skin penetration enhancer that is scarcely utilized in ophthalmic drug formulations. We describe here a low-dose formulation of 0.25% PVP-I in a gel containing DMSO for the treatment of Demodex blepharitis. CASE REPORT: A 95-year-old female presented with chronic blepharitis involving both the anterior and posterior eyelid margins...
June 22, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28643058/prospective-randomized-comparison-of-the-use-of-floshield-air-system-%C3%A2-versus-the-reference-technique-water%C3%A2-%C3%A2-povidone-iodine-solution-during-gynecologic-endoscopic-surgery-to-evaluate-the-operative-lens-vision-quality
#2
S Bendifallah, E Salakos, I Naoura, P Aristizabal, E Furet, S Zilberman, M Ballester, E Darai
BACKGROUND: The FloShield Air System(®) is a new device for laparoscopic surgery that utilizes a continuous dry CO2 gas flow over the scope to defog the lens and protect it from condensation, debris and smoke. We set out to compare the performance and efficiency of the device in terms of operative lens vision quality (OLVQ) with the reference technique (water + povidone-iodine (PVI) solution) during gynecologic laparoscopic surgery. MATERIALS AND METHODS: We conducted a single-center randomized prospective study between March and June 2016 (Trials Database Registration NCT02702531) including 53 patients undergoing gynecologic laparoscopic surgery with water + PVI solution and 51 patients who underwent surgical procedures with the FloShield Air System...
June 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28642200/enhancement-of-solubility-and-dissolution-rate-of-baicalein-wogonin-and-oroxylin-a-extracted-from-radix-scutellariae
#3
Hang Yu, Jae-Sang Chang, Sun Young Kim, Yoon G Kim, Hoo-Kyun Choi
Baicalein, wogonin, and oroxylin A are three major hydrophobic components in the extract of Radix scutellariae with wide spectrum of pharmacological applications. The purpose of this study was to enhance the solubility, dissolution rate and stability of baicalein, wogonin and oroxylin A by solid dispersion (SD) technique. SD of the extract with various polymers was prepared to select the best carrier. Solubility study, chemical stability study and dissolution study were performed to characterize the SD. The solubility of all three components, after forming solid dispersion with povidone K-30 (PVP K-30) was significantly increased in pH 6...
June 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28627491/survival-growth-performance-and-immune-capacity-of-the-juvenile-lined-seahorse-hippocampus-erectus-fed-with-rifampicin-treated-copepods
#4
Tingting Lin, Changbo Wang, Xin Liu, Fen Gao, Dongxue Xiao, Dong Zhang, Xialian Zhu
Gastrointestinal disease is one of the most serious diseases in cultured seahorse juveniles. Treatment with antimicrobials of live food (i.e. copepods and Artemia) that is used to feed the juveniles may be a promising measure to alleviate the occurrence of gastrointestinal disease. However, relevant investigations are rare. In the present study, we first investigated the antimicrobial efficacies on bacteria within copepods that were treated with 4 antimicrobials, including 3 antibiotics (i.e. enrofloxacin hydrochloride, oxytetracycline and rifampicin [RFP]) that are approved for use in aquaculture and 1 disinfectant (i...
June 19, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28627470/investigation-of-itraconazole-ternary-amorphous-solid-dispersions-based-on-povidone-and-carbopol
#5
Fan Meng, Jordan Meckel, Feng Zhang
We investigate a ternary system that consists of itraconazole (ITZ) and two polymers: povidone K12 and Carbopol 907. The interactions between these two polymers and their effects on the properties of ternary ITZ amorphous solid dispersions (ASDs) are studied. These two polymers can form a water-insoluble complex in acidic aqueous media. The critical pH is determined to be 4.17. The weight percentage of Carbopol 907 in the interpolymer complex range from 59 to 70%, depending on the initial ratios between these two polymers in the starting solutions...
June 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28609415/effect-of-povidone-iodine-5-on-the-cornea-vision-and-subjective-comfort
#6
William H Ridder, Caren Oquindo, Kavita Dhamdhere, James Burke
PURPOSE: To determine the effects of povidone iodine 5% (Betadine 5%) applied to the eye on visual function, corneal integrity, and subjective complaints. METHODS: Ten subjects were chosen to participate in this study (average age 40.6 ± 19.6; age range 22-68). LogMAR acuity, contrast sensitivity, corneal fluorescein staining, and subjective complaints were measured before and after 60 μl of Betadine 5% or saline were applied to one eye (eligibility visit, baseline, 5, 30, and 60 minutes and 4 and 24 hours post-application)...
June 10, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28599898/a-randomized-open-label-controlled-trial-of-chlorhexidine-alcohol-versus-povidone-iodine-for-cesarean-antisepsis-the-capica-trial
#7
Edward H Springel, Xiao-Yu Wang, Vanessa M Sarfoh, Bradley P Stetzer, Steven A Weight, Brian M Mercer
BACKGROUND: Identification of optimal surgical site antisepsis preparations may reduce cesarean-related surgical site infections. Two recently published investigations examined efficacy of chlorhexidine-alcohol and iodine-alcohol preparations. No previous randomized controlled trial has compared chlorhexidine-alcohol to povidone-iodine aqueous scrub and paint in reduction of cesarean-related surgical site infection. OBJECTIVE: The purpose of the study was to determine if chlorhexidine-alcohol would result in less surgical site infections than povidone-iodine when used as skin antisepsis preparation prior to cesarean delivery...
June 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28590912/quantitative-analysis-of-povidone-iodine-thin-films-by-x-ray-photoelectron-spectroscopy-and-their-physicochemical-properties
#8
Anongtip Sa, Somchai Sawatdee, Narubodee Phadoongsombut, Wilaiporn Buatong, Titpawan Nakpeng, Rutthapol Sritharadol, Teerapol Srichana
In this study, povidone-iodine (PVP-I) has been formulated as a topical spray to produce a thin film for the controlled release of I2. By means of experimental design, 27 formulations containing glycerol, ethanol, PEG 400, copovidone and HFA 134a as a propellant were prepared. The pH values of all formulations were in the range of 6-7. The viscosity was within the range of 11.9-85.9 mPa s. The surface tensions were 20.3 to 24.6 mN m-1 and the contact angles were between 19.3 and 38.7°. The assays for the iodine contents were within acceptable range (80-120 %)...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28583892/preoperative-chlorhexidine-versus-povidone-iodine-antisepsis-for-preventing-surgical-site-infection-a-meta-analysis-and-trial-sequential-analysis-of-randomized-controlled-trials
#9
REVIEW
Dan Zhang, Xi-Chen Wang, Zeng-Xi Yang, Jian-Xin Gan, Jie-Bin Pan, Lan-Ning Yin
BACKGROUNDS: Updated guidelines for surgical site infections (SSIs) suggested that chlorhexidine (CH) or povidone-iodine (PVI) product was equally appropriate to be applied in preoperative disinfection, but which one was optimal remained ambiguous. Moreover, recent studies reported inconsistent results. Thus, an updated meta-analysis was conducted to clarify the superiority of CH or PVI for prevention of SSIs in clean and clean-contaminated surgery. METHODS: From the inception to November 2016, Pubmed, Embase, and the Cochrane library were systematically searched for randomized controlled trials (RCTs) which explored preoperative antisepsis schemes (CH or PVI) for prevention of SSIs in clean and clean-contaminated surgery...
June 2, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28581066/the-pregnant-urologist
#10
Susan Jane Hall, Simon Williams
The latest statistics show that females constitute 15% of UK Urology consultants and 30% of Urology trainees. This number is set to rise with females accounting for 60% of recent medical school intakes (1). Having young female trainees will result in a larger number of trainees working during pregnancy. Furthermore Urology as a specialty involves potential risks to the developing foetus and mother from both ionising radiation in theatre and from exposure to the potentially harmful 5 α reductase inhibitors, Povidone-iodine surgical scrub, cytotoxic chemicals such as Mitomycin, along with long working hours and on call duties...
June 5, 2017: BJU International
https://www.readbyqxmd.com/read/28578841/povidone-iodine-based-solutions-for-decolonization-of-nasal-staphylococcus-aureus-a-randomized-prospective-placebo-controlled-study
#11
Maryam Rezapoor, Thema Nicholson, Reza Mostafavi Tabatabaee, Antonia F Chen, Mitchell G Maltenfort, Javad Parvizi
BACKGROUND: Nasal Staphylococcus aureus decolonization reduces the risk of surgical site infections after orthopedic procedures. Povidone-iodine (PI)-based solutions have shown promising results in bacteria decolonization. The unique physiology of the nose may pose challenges for the bioactivity profiles of PI solutions. This study compared the antibacterial efficacy of an off-the-shelf PI product with a specifically manufactured PI-based skin and nasal antiseptic (SNA). METHODS: This randomized, placebo-controlled study was conducted at a single institution between April 2014 and July 2015...
May 3, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28557536/preoperative-hand-decontamination-in-ophthalmic-surgery-a-comparison-of-the-removal-of-bacteria-from-surgeons-hands-by-routine-antimicrobial-scrub-versus-an-alcoholic-hand-rub
#12
Yaara Forer, Colin Block, Shahar Frenkel
PURPOSE: The goal of this experiment was to evaluate and compare the antimicrobial efficacy of routine preoperative hand washing using commercial medicated sponge brushes versus an alcoholic hand rub, by comparing bacterial growth on ophthalmic surgeons' hands after application of each of these methods. METHODS: Twenty ophthalmic surgeons were recruited at the Hadassah-Hebrew University Medical Center in Jerusalem, Israel. Samples were collected twice from the hands of each surgeon after hand decontamination using two different protocols during routine surgical practice...
May 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28556416/new-developments-in-chyluria-after-global-programs-to-eliminate-lymphatic-filariasis
#13
REVIEW
Anuruddha M Abeygunasekera, Kugadas Sutharshan, Balasingam Balagobi
Chyluria, commonly seen in south Asian countries, is mainly a manifestation of lymphatic filariasis as a result of infestation with Wuchereria bancrofti, although many other causes can contribute. Many patients can be effectively treated with dietary modifications and drug therapy. The most widely used drug is diethyl carbamazine. The recurrences are common after such treatment. Such patients would benefit from sclerotherapy to obliterate the lympatico-renal fistulae located mainly in the renal pelvicalyceal system...
May 26, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28552799/an-explorative-analysis-of-process-and-formulation-variables-affecting-comilling-in-a-vibrational-mill-the-case-of-praziquantel
#14
Beatrice Perissutti, Nadia Passerini, Ramona Trastullo, Jennifer Keiser, Debora Zanolla, Guglielmo Zingone, Dario Voinovich, Beatrice Albertini
Praziquantel, a BCS II class anthelmintic drug used for the treatment of schistosome infections, was coground in a vibrational mill with different polymers (linear and crosslinked povidone, copovidone and sodium starch glycolate). An explorative analysis of formulation variables (drug-polymer wt ratio and polymer type) and process parameters (type of grinding media, grinding time and frequency) was carried out with the help of an experimental screening design. The influence of the above mentioned factors on three PZQ characteristics (residual crystallinity, water solubility enhancement and drug recovery) was studied...
May 24, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28549873/comparison-of-the-recovery-rate-of-otomycosis-using-betadine-and-clotrimazole-topical-treatment
#15
Mohammad Reza Mofatteh, Zahra Naseripour Yazdi, Masoud Yousefi, Mohammad Hasan Namaei
INTRODUCTION: Otomycosis is a common diseases that can be associated with many complications including involvement of the inner ear and mortality in rare cases. Management of otomycosis can be challenging, and requires a close follow-up. Treatment options for otomycosis include local debridement, local and systemic antifungal agents and utilization of topical antiseptics. OBJECTIVE: This study was designed to compare the recovery rate of otomycosis using two therapeutic methods; topical betadine (Povidone-iodine) and clotrimazole...
May 6, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28537349/effects-of-topical-antiseptic-solutions-used-during-total-knee-arthroplasty-on-suture-tensile-strength
#16
Jared M Newman, Jaiben George, Jeffery T Shepherd, Alison K Klika, Carlos A Higuera, Viktor E Krebs
INTRODUCTION: Irrigating a surgical wound with an antiseptic solution is commonly performed while suturing following a total knee arthroplasty (TKA) to help prevent wound complications. The purpose of this study was to: 1) evaluate the mean load to failure of different sutures, and 2) compare the mean load to failure of the sutures after soaking in four different antiseptic solutions. MATERIALS AND METHODS: Load-to-failure tests were conducted on four sets of comparable sutures (eight sutures) from two different companies Ethicon Inc...
May 24, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28529859/treatment-of-periprosthetic-joint-infection-using-antimicrobials-dilute-povidone-iodine-lavage
#17
REVIEW
John A Ruder, Bryan D Springer
Periprosthetic joint infections (PJI) remain a challenge for the orthopaedic surgeon to treat and remain a leading cause of failure of both primary and revision total joint arthroplasty. Once a PJI develops, surgical treatment is generally indicated and includes an aggressive irrigation and debridement. One component of the irrigation and debridement involves the use of an antiseptic irrigating solution. In primary and revision TJA, dilute povidone-iodine lavage can be performed prior to wound closure. Approximately 17...
2017: Journal of bone and joint infection
https://www.readbyqxmd.com/read/28529858/hydrogen-peroxide-wound-irrigation-in-orthopaedic-surgery
#18
REVIEW
Min Lu, Erik Nathan Hansen
As the burden of deep hardware infections continues to rise in orthopaedics, there is increasing interest in strategies for more effective debridement of colonized tissues and biofilm. Hydrogen peroxide has been used medically for almost a century, but its applications in orthopaedic surgery have yet to be fully determined. The basic science and clinical research on the antiseptic efficacy of hydrogen peroxide have demonstrated its efficacy against bacteria, and it has demonstrated potential synergy with other irrigation solutions such as chlorhexidine and povidone-iodine...
2017: Journal of bone and joint infection
https://www.readbyqxmd.com/read/28520604/in-vitro-evaluation-of-betafoam-a-new-polyurethane-foam-dressing
#19
Jae-A Jung, Seung-Kyu Han, Seong-Ho Jeong, Eun-Sang Dhong, Kang-Gyun Park, Woo-Kyung Kim
BACKGROUND: A new polyurethane foam dressing impregnated with 3% povidone-iodine (Betafoam; Genewell, Seoul, Korea) was recently developed based on the hypothesis that its physical properties, including improved moisture-retention capacity and antimicrobial activity, are at least as good as those achieved with the current foam dressings that contain silver, but also associated with reduced cost and cytotoxicity to host cells. The purpose of this in vitro study was to evaluate the efficacy of Betafoam by comparing its physical properties, antimicrobial activity, and cytotoxicity with those of 3 silver foam dressings (Allevyn-Ag [Smith & Nephew, Hull, United Kingdom]; Mepilex-Ag [Mölnlycke Health Care, Gothenburg, Sweden]; and PolyMem-Ag [Ferris MFG Corp, Burr Ridge, Illinois]) used worldwide...
June 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28516852/effects-of-olanexidine-gluconate-on-preoperative-skin-preparation-an-experimental-study-in-cynomolgus-monkeys
#20
Hikaru Nakata, Yoshie Tsubotani, Takuya Nii, Akifumi Hagi, Yasuhide Inoue, Tadashi Imamura
PURPOSE: To determine the bactericidal efficacy of a new topical antiseptic for preoperative skin preparation, olanexidine gluconate (development code: OPB-2045G), against transient or resident bacterial flora on the skin of cynomolgus monkeys. METHODOLOGY: After measuring baseline bacterial counts on test sites marked on the abdomens, we applied olanexidine, chlorhexidine or povidone-iodine. After 10 min (fast-acting effect) and 6 h (long-lasting effect), bacterial counts were measured again and log10 reductions were calculated...
May 2017: Journal of Medical Microbiology
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