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https://www.readbyqxmd.com/read/29775686/the-comparative-efficacy-of-antiseptics-against-candida-auris-biofilms
#1
Ryan Kean, Emily McKloud, Eleanor M Townsend, Leighann Sherry, Christopher Delaney, Brian L Jones, Craig Williams, Gordon Ramage
Candida auris has emerged as a significant clinical entity due to its ability to cause outbreaks within the healthcare setting. A key feature of its nosocomial lifestyle is its ability to transfer between patients, yet little is known about the mechanisms behind this. A panel of C. auris clinical isolates was screened for their planktonic and sessile susceptibilities to skin disinfection challenge using povidone iodine, chlorhexidine and hydrogen peroxide. C. auris biofilms displayed increased tolerance to these strategies compared to planktonic cells...
May 15, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29772696/the-effect-of-negative-pressure-wound-therapy-with-and-without-instillation-on-mature-biofilms-in-vitro
#2
Shamaila Tahir, Matthew Malone, Honghua Hu, Anand Deva, Karen Vickery
BACKGROUND: To investigate the effect of negative pressure wound therapy (NPWT) with and without instillation (NPWTi) on in vitro mature biofilm. METHODS: Mature biofilms of Pseudomonas aeruginosa and Staphylococcus aureus were grown under shear (130 rpm) on polycarbonate coupons in a CDC biofilm reactor for 3 days. Coupons containing biofilms were placed in a sterile petri dish and sealed using NPWT or NPWTi. Coupons were exposed to treatment for 24 h with NPWT alone or with instillation of: Povidone iodine solution (PVP-I) (10% w / v equivalent to 1% w / v available iodine, BETADINE® , Mundipharma, Singapore), surfactant based antimicrobial solution with polyhexamethylene biguanide (SBPHMB) (Prontosan® , B Braun Medical, Melsungen, Germany), Gentamicin 1 µg/mL (GM) (G1264 Sigma-Aldrich Pty Ltd...
May 16, 2018: Materials
https://www.readbyqxmd.com/read/29767713/commentary-on-hypochlorous-acid-versus-povidone-iodine-containing-irrigants-which-antiseptic-is-more-effective-for-breast-implant-pocket-irrigation
#3
Roger N Wixtrom
No abstract text is available yet for this article.
May 14, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29765867/tongue-reshaping-a-new-surgical-method-to-prevent-self-sucking-in-dairy-cows
#4
Mohamed Wefky El-Sherif
Self-sucking behaviors lead to substantial milk loss and inflammation of the udder and teats among dairy cows. Both conservative and surgical approaches are available to prevent such behavior; however, the current methods are limited by variable efficacy and risk of complications. The objective of the present study was to evaluate a new minimally invasive technique for reshaping of the tongue to prevent self-sucking. The current technique was performed on five mixed breed dairy cows aged 4-6 years and with a mean weight 320 kgs...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29761329/bactericidal-and-virucidal-activity-of-povidone-iodine-and-chlorhexidine-gluconate-cleansers-in-an-in-vivo-hand-hygiene-clinical-simulation-study
#5
Maren Eggers, Torsten Koburger-Janssen, Lois S Ward, Craig Newby, Stefan Müller
INTRODUCTION: Standard in vitro and in vivo tests help demonstrate efficacy of hand hygiene products; however, there is no standard in vivo test method for viruses. We investigated the bactericidal and virucidal efficacy of povidone-iodine (PVP-I) 7.5% scalp and skin cleanser, chlorhexidine gluconate (CHG) 4% hand cleanser and the reference hand wash (soft soap) in 15 healthy volunteers following European Standard EN1499 (hygienic hand wash test method for bacteria), which was adapted for virucidal testing...
May 14, 2018: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/29753031/antiseptic-agents-elicit-short-term-personalized-and-body-site-specific-shifts-in-resident-skin-bacterial-communities
#6
Adam J SanMiguel, Jacquelyn S Meisel, Joseph Horwinski, Qi Zheng, Charles W Bradley, Elizabeth A Grice
Despite critical functions in cutaneous health and disease, it is unclear how resident skin microbial communities are altered by topical antimicrobial interventions commonly used in personal and clinical settings. Here we show that acute exposure to antiseptic treatments elicits rapid but short-term depletion of microbial community diversity and membership. Thirteen subjects were enrolled in a longitudinal treatment study to analyze the effects of topical treatments (ethanol, povidone-iodine, chlorhexidine, water) on the skin microbiome at two skin sites of disparate microenvironment: forearm and back...
May 9, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29738292/comparison-of-antimicrobial-activity-of-selected-commercially-available-wound-dressing-materials
#7
Piotr Szweda, Grzegorz Gorczyca, Robert Tylingo
OBJECTIVE: The aim of our study was to examine the antimicrobial potential of eight selected, commercially available wound dressings containing different antimicrobial agents: silver, chlorhexidine acetate, povidone-iodine, and manuka honey. METHOD: The materials were tested against four reference strains of bacteria: Staphylococcus aureus (PCM 2051), Staphylococcus epidermidis (PCM 2118), Pseudomonas aeruginosa (ATCC 27853), and Escherichia coli (K12), using the disc diffusion-like method and a time-killing assay...
May 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29727653/chitosan-nanoparticles-and-povidone-iodine-containing-alginate-gel-for-prevention-and-treatment-of-orthopedic-implant-associated-infections
#8
Vaishali Pawar, Harshad Topkar, Rohit Srivastava
Implant associated infections are the most serious complications in the orthopedic surgery. Such complications are of major concern unless encountered during initial stages of contamination due to the bacterial biofilm formation. Thus, our aim is to eradicate bacteria at the early stages of infection. Herein, we develop a vancomycin-loaded chitosan nanoparticles (CNPs) and povidone-iodine (PI) containing in situ alginate (CNPs-PI-Alg) gel for antibacterial and antibiofilm activity, respectively. The CNPs were synthesized by ionic gelation method and the processing parameters were optimized to attain nanoparticles of 200-250 nm size and 37...
May 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29704562/a-survey-to-identify-the-breach-between-evidence-and-practice-in-the-prevention-of-surgical-infection-time-to-take-action
#9
REVIEW
Josep M Badia, Anna L Casey, Inés Rubio-Pérez, Cynthia Crosby, Nares Arroyo-García, José Balibrea Del Castillo
BACKGROUND: The knowledge of the grade of implementation of preventative measures for surgical site infection (SSI) is crucial prior to planning dissemination strategies. METHODS: Online survey among the members of the Spanish Association of Surgeons (AEC) to know the actual application of measures, and to compare them with new recommendations issued by international organizations. RESULTS: Most of the 835 responding surgeons work in National Health Service Hospitals (91...
April 25, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29697470/update-on-techniques-to-prevent-infections-associated-with-prostate-needle-biopsy
#10
Matteo Fontana, Luca Boeri, Emanuele Montanari
PURPOSE OF REVIEW: Postbiopsy infections (PBIs) are among the most common complications associated with transrectal ultrasound-guided prostate biopsy (TRUSPB). This article discusses the pathogenesis of TRUSPB-associated infectious complications and reviews the most recent findings on techniques to prevent PBIs. RECENT FINDINGS: Risk stratification is a powerful tool for identifying TRUSPB candidates whom warrant additional preventive measures. Bowel preparation with povidone-iodine-based enemas and needle disinfection with formalin solution are simple and attractive strategies, but their effectiveness needs to be thoroughly assessed...
April 24, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29681944/antibacterial-effect-of-hypochlorous-acid-solution-on-nasal-discharge-from-patients-with-chronic-rhinosinusitis
#11
Shang-Heng Wu, Jen-Fu Lin, Rong-San Jiang
Purpose: The antibacterial effect of hypochlorous acid (HOCl) solution on nasal secretion of patients with chronic rhinosinusitis (CRS) was investigated. Materials and Methods: Five swab specimens were collected from the middle meatus of CRS patients. The first one was placed directly in a Thanswab tube while all of the others were placed randomly into 4 glass tubes containing either HOCl solution, normal saline (NS), 75% alcohol, or povidone-iodine (PVPI) solution for one minute in the first part and for 5 minutes in the second part of the study before transfer to a Thanswab tube...
2018: International Journal of Otolaryngology
https://www.readbyqxmd.com/read/29670217/bacterial-derived-exopolysaccharides-enhance-antifungal-drug-tolerance-in-a-cross-kingdom-oral-biofilm
#12
Dongyeop Kim, Yuan Liu, Raphael I Benhamou, Hiram Sanchez, Áurea Simón-Soro, Yong Li, Geelsu Hwang, Micha Fridman, David R Andes, Hyun Koo
Fungal-bacterial interactions generate unique biofilms that cause many infections in humans. Candida albicans interact with Streptococcus mutans in dental biofilms associated with severe childhood tooth-decay, a prevalent pediatric oral disease. Current modalities are ineffective and primarily based on antimicrobial monotherapies despite the polymicrobial nature of the infection. Here, we show that the combination of clinically used topical antifungal fluconazole with povidone iodine (PI) can completely suppress C...
April 18, 2018: ISME Journal
https://www.readbyqxmd.com/read/29627326/one-percent-chlorhexidine-alcohol-for-preventing-central-venous-catheter-related-infection-during-intensive-chemotherapy-for-patients-with-haematologic-malignancies
#13
Shimon Ohtake, Hiromichi Takahashi, Masaru Nakagawa, Yoshihito Uchino, Katsuhiro Miura, Noriyoshi Iriyama, Tomohiro Nakayama, Yoshihiro Hatta, Masami Takei
A central venous catheter (CVC) is a catheter placed into a large vein, and is used for chemotherapy administration. However, there is little confirmatory data on which antiseptic-such as chlorhexidine or povidone-iodine (PI) -is more protective against CVC-related infectious complications in patients receiving intensive chemotherapy. We aimed to compare the effectiveness of 1% chlorhexidine gluconate in 70% alcohol (CH) vs. PI for skin disinfection before CVC insertion in patients receiving intensive chemotherapy...
April 4, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29623716/development-of-the-composition-of-intramammary-combined-preparation-based-on-silver-citrate-for-veterinary-use
#14
Zhanna Polova, Lyudmyla Almakayeva, Tetiana Nehoda
The goal of the present study was to develop a new intramammary combination preparation for veterinary use based on silver citrate, arginine and dexpanthenol for the treatment and prophylaxis of subclinical mastitis in cattle. When creating combined medicines for veterinary use, attention must be paid to the factors that influence their stability in a combined presence, and the composition of drugs, as well as the technology for their preparation should be determined. In the current study, a qualitative and quantitative control of model mixtures of active ingredients, as well as of a silver citrate-based combined preparation was carried out...
2018: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/29621560/in-vitro-comparative-cytotoxicity-study-of-a-novel-biocidal-iodo-thiocyanate-complex
#15
Lilit Tonoyan, Aoife Boyd, Gerard T A Fleming, Ruairi Friel, Carol M Gately, Paul H Mc Cay, Vincent O'Flaherty
Novel biocides, which avoid the induction of cross-resistance to antibiotics, are an urgent societal requirement. Here, we compared the cytotoxic and bactericidal effects of a new antimicrobial agent, the iodo-thiocyanate complex (ITC), with those of the common antiseptics, hydrogen peroxide (H2 O2 ), povidone iodine (PVP-I) and Lugol's iodine (Lugol). The antimicrobials were co-incubated for 10 min with HeLa and Escherichia coli cells in the presence and absence of organic matter (Dulbecco's modified Eagle's medium, supplemented with 10% fetal bovine serum)...
April 2, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29609860/prophylaxis-of-surgical-site-infection-in-adult-spine-surgery-a-systematic-review
#16
REVIEW
Reina Yao, Terence Tan, Jin Wee Tee, John Street
INTRODUCTION: Surgical site infection (SSI) remains a significant source of morbidity in spine surgery, with reported rates varying from 0.7 to 16%. OBJECTIVE: To systematically review and evaluate the evidence for strategies for prophylaxis of SSI in adult spine surgery in the last twenty years. METHODS: Two independent systematic searches were conducted, at two international spine centers, encompassing PubMed, ClinicalTrials.gov, Cochrane Database, EBSCO Medline, ScienceDirect, Ovid Medline, EMBASE (Ovid), and MEDLINE...
March 30, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29607479/percutaneous-endoscopic-gastrostomy-in-ile-ife-nigeria-an-initial-report
#17
O I Alatise, M A Komolafe, E A Agbakwuru, A O Adisa, Y B Amusa
BACKGROUND: Protein-energy malnutrition is a common problem in critically ill patient and it is a major cause of accelerated morbidity and mortality in this group of patients. Recent dramatic advances in both enteral and parenteral nutritional support have ensured that most of these critically ill patients are adequately nutritionally supported. Unfortunately, most of these advancements in nutritional supports are far from the reach of most patients in developing countries. In this report, we highlighted the indications, success, challenges of the use of percutaneous endoscopic gastrostomy (PEG) in Nigeria patients...
January 2018: West African Journal of Medicine
https://www.readbyqxmd.com/read/29540169/skin-asepsis-protocols-as-a-preventive-measure-of-surgical-site-infections-in-dogs-chlorhexidine-alcohol-versus-povidone-iodine
#18
Luís Belo, Isa Serrano, Eva Cunha, Carla Carneiro, Luis Tavares, L Miguel Carreira, Manuela Oliveira
BACKGROUND: Most of surgical site infections (SSI) are caused by commensal and pathogenic agents from the patient's microbiota, which may include antibiotic resistant strains. Pre-surgical asepsis of the skin is one of the preventive measures performed to reduce SSI incidence and also antibiotic resistance dissemination. However, in veterinary medicine there is no agreement on which biocide is the most effective. The aim of this study was to evaluate the effectiveness of two pre-surgical skin asepsis protocols in dogs...
March 14, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29506927/cost-efficacy-of-methicillin-resistant-staphylococcus-aureus-decolonization-with-intranasal-povidone-iodine
#19
G Ryan Rieser, Joseph T Moskal
BACKGROUND: With increasing rates of virulent drug resistant organisms, MRSA (methicillin-resistant Staphylococcus aureus) decolonization has been demonstrated to decrease infection rates. Recent research has shown the antiseptic povidone-iodine to be equally effective and potentially cost saving compared to intranasal mupirocin. This study's purpose is to evaluate the incidence of MRSA colonization in a more rural community-based population, rates of infection on a mupirocin decolonization protocol, and develop a cost analysis model to compare costs of utilizing povidone-iodine...
January 31, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29490694/systematic-review-of-ototoxic-pre-surgical-antiseptic-preparations-what-is-the-evidence
#20
REVIEW
Shubhi Singh, Brian Blakley
OBJECTIVE: There is uncertainty regarding the safety of surgical antiseptic preparations in the ear. A systematic review of the literature was conducted to assess the evidence regarding ototoxicity of surgical antiseptic preparations. METHODS: A literature search was conducted using the PRISMA methods. Key words included "ototoxicity" "hearing loss", "antiseptic", "surgical preparation", "tympanoplasty", "vestibular dysfunction", "chlorhexidine", "iodine", "povidone", "ethanol", and "hydrogen peroxide" using Medline, Embase, Cochrane Library, Scopus and Web of Science...
March 1, 2018: Journal of Otolaryngology—Head & Neck Surgery
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