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Chlorhexidine

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https://www.readbyqxmd.com/read/28229586/chlorhexidine-loaded-amorphous-calcium-phosphate-nanoparticles-for-inhibiting-degradation-and-inducing-mineralization-of-type-i-collagen
#1
Xue Cai, Bing Han, Yan Liu, Fucong Tian, Fuxin Liang, Xiaoyan Wang
A major shortcoming of contemporary dentin adhesives is their limited durability. Exposed collagen fibrils within the bonding interface are degraded by matrix metalloproteinases (MMPs), resulting in aging of the resin-dentin bond. In this study, chlorhexidine-loaded amorphous calcium phosphate (ACP) nanoparticles were synthesized to induce the mineralization of collagen fibrils. The nanoparticles sustainably released chlorhexidine, to inhibit MMPs during mineralization. Three types of ACP nanoparticles were prepared: N-ACP containing no chlorhexidine, C-ACP containing chlorhexidine acetate, and G-ACP containing chlorhexidine gluconate, which had a higher drug-loading than C-ACP...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28228624/antibacterial-efficacy-of-several-intracanal-medicaments-for-endodontic-therapy
#2
Marta E Valverde, Pilar Baca, Laura Ceballos, M Victoria Fuentes, Matilde Ruiz-Linares, Carmen María Ferrer-Luque
The antibacterial efficacy of intracanal medicaments for 2 and 7 days, in open apex root canals contaminated with Enterococcus faecalis biofilms was compared. One hundred and thirty-eight standardized uniradicular human roots were inoculated with E. faecalis. Colony forming units (CFU) were recorded before and after medication. Samples were divided in two (2/7 days), and subdivided (n=8/group): triple antibiotic paste (TAP); double antibiotic paste (DAP); dental base paste (DBP), consisting of calcium hydroxide, propylene glycol and calcium carbonate; DBP+0...
February 22, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28223246/physical-key-properties-of-antibiotic-free-plga-hpmc-based-in-situ-forming-implants-for-local-periodontitis-treatment
#3
K Agossa, M Lizambard, T Rongthong, E Delcourt-Debruyne, J Siepmann, F Siepmann
In-situ forming implants (ISFI) offer an interesting potential for the treatment of periodontitis, allowing for time-controlled drug release directly at the site of action (which is difficult to reach). For this purpose, ISFI loaded with antibiotics have been reported in the literature. But the use of antibiotic drugs at low doses over prolonged periods of time can lead to the development of bacterial resistances. This risk should be avoided. The aim of this study was to develop a novel type of in-situ forming implants, loaded with the antiseptic drug chlorhexidine...
February 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28219420/umbilical-cord-care-practices-in-low-and-middle-income-countries-a-systematic-review
#4
Patricia S Coffey, Siobhan C Brown
BACKGROUND: Neonatal sepsis is the third leading cause of deaths for infants in their first month of life. The newly cut umbilical cord can be a pathway for bacteria that can cause newborn sepsis and death. Optimal umbilical cord care practices for newborns and during the first week of life, especially in settings with poor hygiene, has the potential to avoid these preventable neonatal deaths. The purpose of this review of cord care practices is to assist in the development of behavior-change strategies to support introduction of novel cord-care regimens, particularly 7...
February 20, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28218496/functional-analysis-of-bioactivated-surfaces
#5
Selgai Haidari, Marko Boskov, Ulrike Schillinger, Klaus-Dietrich Wolff, Christian Plank, Andreas Kolk
Common scaffold surfaces, such as titanium, can have side effects, e.g., infections, cytotoxicity, impaired osseointegration or low regeneration rates for bone tissue. These effects lead to poor implant integration or even implant loss. Therefore, bioactive implants are promising instruments in tissue regeneration. Osteoinductive elements, such as growth factors and anti-infectives, support wound healing and bone growth and thereby enable faster osseointegration, even in elderly patients. In this study, titanium surfaces were coated with a poly-(D,L-lactide) (PDLLA) layer containing different concentrations of copolymer-protected gene vectors (COPROGs) to locally provide bone morphogenetic protein-2 (BMP-2) or activated anti-infective agents, such as chlorhexidine gluconate, triclosan and metronidazole, to prevent peri-implantitis...
February 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28218483/antimicrobial-potential-and-gustatory-perception-of-chlorhexidine-gluconate-mouthwashes-with-or-without-alcohol-after-a-single-rinse-a-randomized-controlled-crossover-clinical-trial
#6
R Cantarelli, T C Negrini, Fwmg Muniz, Hjr Oballe, R A Arthur, C K Rösing
OBJECTIVE: The aim of this double-blind randomized clinical trial was to assess whether the presence of alcohol in chlorhexidine gluconate mouthwashes influences their antimicrobial potential against salivary bacteria in young adults. Additionally, the taste perception was assessed. MATERIALS AND METHODS: In a randomized crossover design, 20 participants (17 women and three men; aged 18-38 years old) rinsed with the 0.12% chlorhexidine gluconate with (CHX+) or without alcohol (CHX-) for 1 min...
November 7, 2016: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28217816/candida-albicans-survival-growth-and-biofilm-formation-are-differently-affected-by-mouthwashes-an-in-vitro-study
#7
Simona Paulone, Giulia Malavasi, Andrea Ardizzoni, Carlotta Francesca Orsi, Samuele Peppoloni, Rachele Giovanna Neglia, Elisabetta Blasi
Candida albicans is the most common cause of oral mycoses. The aim of the present study was to investigate in vitro the susceptibility of C. albicans to mouthwashes, in terms of growth, survival and biofilm formation. Candida albicans, laboratory strain SC5314, and 7 commercial mouthwashes were employed: 3 with 0.2% chlorhexidine digluconate; 1 with 0.06% chlorhexidine digluconate and 250 ppm F- sodium fluoride; 3 with fluorine-containing molecules. None of the mouthwashes contained ethanol in their formulations...
January 2017: New Microbiologica
https://www.readbyqxmd.com/read/28216018/prospective-randomised-controlled-study-evaluating-early-modification-of-oral-microbiota-following-admission-to-the-intensive-care-unit-and-oral-hygiene-with-chlorhexidine
#8
Felipe Francisco Tuon, Oleg Gavrilko, Saulo de Almeida, Eigi Ricardo Sumi, Thiago Alberto, Jaime Luis Rocha, Edvaldo Antonio Rosa
OBJECTIVES: Chlorhexidine (CHX) is the most commonly used oral hygiene product for the prevention of ventilator-associated pneumonia (VAP) in patients undergoing mechanical ventilation (MV). The change in dental plaque (DP) microbiota following CHX use in patients under MV has not been described previously. The aim of this study was to evaluate the incidence of pathogenic bacteria associated with VAP and the coverage of DP within the oral cavity in patients administered CHX. METHODS: This was a prospective, randomised, controlled, double-blind study in patients (n=16) under MV who were mouth-rinsed with either CHX or placebo...
February 18, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28215714/microbiological-effect-of-mupirocin-and-chlorhexidine-for-staphylococcus-aureus-decolonization-in-community-and-nursing-home-based-adults
#9
Mary-Claire Roghmann, Alison D Lydecker, Patricia Langenberg, Emmanuel F Mongodin, J Kristie Johnson
OBJECTIVE: To compare the presence of Staphylococcus aureus and pathogenic Gram-negative rods (GNR) in the anterior nares, posterior pharynx and three skin sites in community-based adults and nursing home-based adults before and after treatment with nasal mupirocin and topical chlorhexidine. METHODS: S. aureus-colonized adults were recruited from the community (n=26) and from nursing homes (n=8). Eligible participants were cultured for S. aureus and GNR during two study visits and then received intranasal mupirocin and topical chlorhexidine for 5days, with a 2-month follow-up period...
February 13, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28210450/repercussions-of-intraalveolar-placement-of-combination-of-0-2-chlorhexidine-10-mg-metronidazole-gel-on-the-occurrence-of-dry-sockets-a-randomized-control-trial
#10
Jasleen Kaur, Rushik Raval, Anupam Bansal, Vinod Kumawat
BACKGROUND: To evaluate the effects of intraalveolar placement of gel containing 0.2% chlorhexidine and 10gm of metronidazole on the incidence of alveolar osteitis. MATERIAL AND METHODS: A total of 300 impacted third molars were extracted in 150 patients enrolled in this trial. In each subject a socket was randomly selected and packed to the crest of alveolar ridge with the gel. The contralateral socket was packed with placebo dressing. The occurrence of dry socket was assessed during 3rd and 5th postoperative days ...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28210436/effect-of-disinfecting-the-cavity-with-chlorhexidine-on-the-marginal-gaps-of-cl-v-giomer-restorations
#11
Soodabeh Kimyai, Fatemeh Pournaghi-Azar, Fereshteh Naser-Alavi, Ashkan Salari
BACKGROUND: Considering the effect of cavity disinfecting agents on the bonding and sealing ability of restorations bonded to dentin, the aim of this study was to evaluate the effect of chlorhexidine (CHX) disinfecting agent on the marginal gaps of Cl V giomer restorations. MATERIAL AND METHODS: Cl V cavities were prepared on the buccal surfaces of 60 sound bovine permanent incisors in this in vitro study, with the occlusal and gingival margins in enamel and dentin, respectively...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28210431/vertical-root-fracture-resistance-of-simulated-immature-permanent-teeth-filled-with-mta-using-different-vehicles
#12
Hacer Aksel, Sevinc Askerbeyli-Örs, Derya Deniz-Sungur
BACKGROUND: The aim of the study is to evaluate the resistance vertical root fracture (VRF) of mineral trioxide aggregate (MTA) filled-immature permanent roots by using three different vehicles. MATERIAL AND METHODS: Forty-extracted human single-rooted mandibular premolars were selected and the root length was standardized to the length of 9 mm. For simulation of immature tooth apices, peeso reamers were introduced into the root canals and the prepared roots were assigned into three experimental groups according the used vehicle (distilled water-DW, prophylene glycol-PG, chlorhexidine-CHX) and control group (n=10)...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28197990/a-chlorhexidine-releasing-epoxy-based-coating-on-titanium-implants-prevents-staphylococcus-aureus-experimental-biomaterial-associated-infection
#13
M Riool, A J Dirks, V Jaspers, L de Boer, T J Loontjens, C M van der Loos, S Florquin, I Apachitei, L N Rijk, H A Keul, S A Zaat
Prevention of biomaterial-associated infections (BAI) remains a challenging problem, in particular due to the increased risk of resistance development with the current antibiotic-based strategies. Metallic orthopaedic devices, such as non-cemented implants, are often inserted under high mechanical stress. These non-cemented implants cannot be protected by e.g. antibioticreleasing bone cement or other antimicrobial approaches, such as the use of bioactive glass. Therefore, in order to avoid abrasion during implantation procedures, we developed an antimicrobial coating with great mechanical stability for orthopaedic implants, to prevent Staphylococcus aureus BAI...
February 14, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28194756/chlorhexidine-allergy-in-4-specialist-allergy-centres-in-the-uk-2009-2013-clinical-features-and-diagnostic-tests
#14
William Egner, Matthew Helbert, Ravishankar Sargur, Kirsty Swallow, Nigel Harper, Tomaz Garcez, Sinisa Savic, Louise Savic, Eren Effren
We describe an observational survey of diagnostic pathways in 104 patients attending four specialist allergy clinics in the UK following perioperative hypersensitivity reactions to chlorhexidine reactions. The majority were life threatening. Men undergoing urological or cardiothoracic surgery predominated. Skin prick testing and sIgE testing were the most common tests used for diagnosis. Fifty-three % of diagnoses were made on the basis of a single positive test. Where multiple tests were performed the sensitivity of intradermal, basophil activation and skin prick testing was 68% (50-86%), 50% (10-90%) and 35% (17-55%) respectively...
February 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28193474/a-new-mouthwash-with-low-concentrations-of-chlorhexidine-seems-to-reduce-intraoral-halitosis-and-volatile-sulfur-compounds-in-patients-after-12-hours-of-use
#15
Romina Brignardello-Petersen
No abstract text is available yet for this article.
February 10, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28193455/assessment-of-the-effectiveness-of-a-ventilator-associated-pneumonia-prevention-bundle-that-contains-endotracheal-tube-with-subglottic-drainage-and-cuff-pressure-monitorization
#16
Ozlem Akdogan, Yasemin Ersoy, Ciğdem Kuzucu, Ender Gedik, Turkan Togal, Funda Yetkin
The effectiveness of prevention bundles on the occurrence and mortality of ventilator associated pneumonia (VAP) was evaluated in many studies. However, the effectiveness of endotracheal tube with subglottic secretion drainage (ETT-SD) and cuff pressure monitorization in VAP bundles have not been adequately assessed. In this study, we aimed to evaluate the effectiveness of VAP bundle containing ETT-SD and cuff pressure monitorization. This was a prospective, controlled study that was carried out between March 2011 and April 2012 including intubated patients...
February 10, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28193164/proposed-phase-2-step-2-in-vitro-test-on-basis-of-en-14561-for-standardised-testing-of-the-wound-antiseptics-pvp-iodine-chlorhexidine-digluconate-polihexanide-and-octenidine-dihydrochloride
#17
Kathrin Schedler, Ojan Assadian, Uta Brautferger, Gerald Müller, Torsten Koburger, Simon Classen, Axel Kramer
BACKGROUND: Currently, there is no agreed standard for exploring the antimicrobial activity of wound antiseptics in a phase 2/ step 2 test protocol. In the present study, a standardised in-vitro test is proposed, which allows to test potential antiseptics in a more realistically simulation of conditions found in wounds as in a suspension test. Furthermore, factors potentially influencing test results such as type of materials used as test carrier or various compositions of organic soil challenge were investigated in detail...
February 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28186862/comparison-of-conventional-syringe-canalbrush-endoactivator-photon-induced-photoacoustic-streaming-and-manual-instrumentation-in-removing-orange-brown-precipitate-an-in-vitro-study
#18
Mehmet Burak Guneser, Asiye Nur Dincer, Dilara Arslan
OBJECTIVE: The aim of this in vitro study was to compare the various techniques for removing precipitate formed after irrigation with sodium hypochlorite (NaOCl) and chlorhexidine (CHX). BACKGROUND DATA: It is still unclear whether different irrigant activation systems can effectively remove precipitate that is firmly attached to the root canal walls. METHODS: Eighty-two extracted single-rooted human teeth were instrumented by using the ProTaper rotary system...
February 10, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28185386/endodontic-irrigation-protocols-effects-on-bonding-of-adhesive-systems-to-coronal-enamel-and-dentin
#19
Marcos Paulo Marchiori Carvalho, Victor Hugo Carvalho Morari, Alexandre Henrique Susin, Rachel De Oliveira Rocha, Luiz Felipe Valandro, Fabio Zovico Maxnuck Soares
OBJECTIVE:  To evaluate the influence of endodontic irrigation protocols on bond strength of total-etch and self-etch adhesive systems to coronal enamel and dentin. MATERIALS AND METHODS:  A total of 66 coronal slices from 11 permanent molars were assigned to six groups (n = 11): endodontic irrigation protocols (5% sodium hypochlorite + 17% EDTA; 2% chlorhexidine gel + saline solution + 17% EDTA or no solution - control) and adhesive systems (Adper Single Bond 2 or Clearfil SE Bond)...
February 10, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28183858/comparison-of-topical-chlorhexidine-and-mupirocin-for-the-prevention-of-exit-site-infection-in-incident-peritoneal-dialysis-patients
#20
Htay Htay, David W Johnson, Sin Yan Wu, Elizabeth L Oei, Marjorie Wai Yin Foo, Jason C Choo
♦ Objective: Prevention of exit-site infection (ESI) is of paramount importance to peritoneal dialysis (PD) patients. The aim of this study was to evaluate the effectiveness of chlorhexidine in the prevention of ESI in incident PD patients compared with mupirocin. ♦ Methods: This retrospective, pre-test/post-test observational study included all incident PD patients at Singapore General Hospital from 2012 to 2015. Patients received daily topical exit-site application of either mupirocin (2012 - 2013) or chlorhexidine (2014 - 2015) in addition to routine exit-site cleaning with 10% povidone-iodine...
February 9, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
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