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https://www.readbyqxmd.com/read/28735355/a-systematic-review-of-dental-disease-management-in-cancer-patients
#1
Catherine H L Hong, Shijia Hu, Thijs Haverman, Monique Stokman, Joel J Napeñas, Jacolien Bos-den Braber, Erich Gerber, Margot Geuke, Emmanouil Vardas, Tuomas Waltimo, Siri Beier Jensen, Deborah P Saunders
INTRODUCTION: This systematic review aims to update on the prevalence of odontogenic-related infections and the efficacy of dental strategies in preventing dental-related complications in cancer patients since the 2010 systematic review. REVIEW METHOD: A literature search was conducted in the databases MEDLINE/PubMed and EMBASE for articles published between 1 January 2009 and 30 June 2016. Each study was assessed by 2 reviewers and the body of evidence for each intervention was assigned an evidence level...
July 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28734651/chromographic-analysis-and-cytotoxic-effects-of-chlorhexidine-and-sodium-hypochlorite-reaction-mixtures
#2
Giuseppina Nocca, Hany Mohamed Aly Ahmed, Giuseppe Ettore Martorana, Cinzia Callà, Gianluca Gambarini, Sandro Rengo, Gianrico Spagnuolo
INTRODUCTION: The literature reveals controversies regarding the formation of para-chloroaniline (PCA) when chlorhexidine (CHX) is mixed with sodium hypochlorite (NaOCl). This study aimed to investigate the stability of PCA in the presence of NaOCl and to examine the in vitro cytotoxic effects of CHX/NaOCl reaction mixtures. METHODS: Different volumes of NaOCl were added to CHX (mix 1) or PCA (mix 2). Upon centrifugation, the supernatant and precipitate fractions collected from samples were analyzed using high-performance liquid chromatography...
July 19, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28731780/evaluation-of-turmeric-chip-compared-with-chlorhexidine-chip-as-a-local-drug-delivery-agent-in-the-treatment-of-chronic-periodontitis-a-split-mouth-randomized-controlled-clinical-trial
#3
Abhilasha Singh, Raja Sridhar, Ravi Shrihatti, Akash Mandloy
AIMS AND OBJECTIVE: The aim of this study was to evaluate and compare the effect of chlorhexidine (CHX) chip and turmeric chip as a local drug delivery (LDD) agent in the treatment of patients with chronic periodontitis. MATERIALS AND METHODS: A total of 120 sites with pocket depths 5-8 mm were chosen as a split mouth design at 3 sites in the same patient. Selected sites were randomly divided into three groups to receive CHX chip in addition to scaling and root planing (SRP) in group A, turmeric chip in addition to SRP in group B, and SRP only in group C...
July 21, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28727160/the-long-term-effect-of-a-zinc-acetate-and-chlorhexidine-diacetate-containing-mouth-rinse-on-intra-oral-halitosis-a-randomized-clinical-trial
#4
Seida Erovic Ademovski, Carina Mårtensson, G Rutger Persson, Stefan Renvert
AIM: To evaluate the long-term effects of a zinc acetate and chlorhexidine diacetate mouth rinse (Zn/CHX) on intra-oral halitosis. MATERIALS AND METHODS: Forty-six adults with intra-oral halitosis were randomized into a 6-month, double-blind, placebo-controlled clinical study. The presence of intra-oral halitosis was evaluated at baseline, 3, and 6 months after treatment by assessment of organoleptic score (OLS) and by total volatile sulphur compounds (T-VSC), hydrogen sulphide (H2 S) and methyl mercaptan (MM) concentrations in exhaled air...
July 20, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28724858/antibacterial-effect-of-azadirachta-indica-neem-or-curcuma-longa-turmeric-against-enterococcus-faecalis-compared-with-that-of-5-sodium-hypochlorite-or-2-chlorhexidine-in-vitro
#5
Dakshita Joy Sinha, Kanwar D S Nandha, Natasha Jaiswal, Agrima Vasudeva, Shashi Prabha Tyagi, Udai Pratap Singh
The purpose of this study was to compare the antibacterial properties of Azadirachta indica (neem) or Curcuma longa (turmeric) against Enterococcus faecalis with those of 5% sodium hypochlorite or 2% chlorhexidine as root canal irrigants in vitro. The activity of neem, chlorhexidine, sodium hypochlorite, or turmeric against E. faecalis was measured on agar plates using the agar diffusion method. The tube dilution method was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the irrigants used...
2017: Bulletin of Tokyo Dental College
https://www.readbyqxmd.com/read/28721998/in-vitro-effect-of-chlorhexidine-gel-on-torque-and-detorque-values-of-implant-abutment-screw
#6
Hamid Neshandar Asli, Bardia Vadiati Saberi, Arezoo Sadat Fatemi
PURPOSE: Use of chlorhexidine (CHX) gel to eliminate the malodor of implant cavity may decrease the friction coefficient and effective preload and result in abutment screw loosening. This study aimed to assess the effect of CHX gel on the preload, torque, and detorque values. MATERIALS AND METHODS: This in vitro experimental study was conducted on three groups of five implants. Group A (G1) was the control group and no material was applied to the implant cavity...
May 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28718886/brainstem-auditory-evoked-responses-in-37-dogs-with-otitis-media-before-and-after-topical-therapy
#7
S Paterson
OBJECTIVES: The objective of this study was to determine whether intra-aural administration of aqueous solutions of marbofloxacin, gentamicin, tobramycin and ticarcillin (used off-licence) was associated with changes in hearing as measured by brainstem auditory evoked responses. MATERIALS AND METHODS: Dogs diagnosed with otitis media (n=37) underwent brainstem auditory evoked response testing and then were treated for their ear disease. First, the external ear canal and middle ear were flushed with sterile saline followed by EDTA tris with 0·15% chlorhexidine...
July 18, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28716502/crystalline-polymorphism-emerging-from-a-milling-induced-amorphous-form-the-case-of-chlorhexidine-dihydrochloride
#8
E Elisei, J F Willart, F Danède, J Siepmann, F Siepmann, M Descamps
In this paper, solid state amorphization induced by mechanical milling is shown to be a useful tool to explore the polymorphism of drugs and their mechanism of devitrification. We show in particular how the recrystallization of amorphous chlorhexidine dihydrochloride obtained by milling reveals a complex polymorphism that involves several polymorphic forms. Two new crystalline forms are identified, one of them appearing as a highly disordered precursor state which however clearly differs from the amorphous one...
July 14, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28714493/handwashing-practices-in-neonatal-intensive-care-unit-paediatric-intensive-care-unit-and-neonatal-nurseries-in-patan-hospital
#9
S Joshi, P Amatya, B Poudel, S A Yadav
BACKGROUND: Hand hygiene has been identified as the single most important factor in minimising hospital acquired infections. However, compliance of handwashing guidelines has remained low. The aim of this study was to study the handwashing practices in the Paediatric and Neonatal intensive care units and Neonatal nurseries in Patan Hospital, and secondly to re-evaluate the improvement on compliance of handwashing guidelines after intervention. METHODS: Pre-intervention study was conducted by covertly observing the handwashing practices by the healthcare workers...
January 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28713766/comparative-evaluation-of-antiplaque-efficacy-between-essential-oils-with-alcohol-based-and-chlorhexidine-with-nonalcohol-based-mouthrinses
#10
Prasad Kulkarni, Dhirendra Kumar Singh, Mohamed Jalaluddin, Arnab Mandal
AIM AND OBJECTIVES: The aim of this study is to compare the antiplaque efficacy of alcohol-based mouthwash with essential oils and nonalcohol-based chlorhexidine mouthrinse in 4 days plaque re-formation study. MATERIALS AND METHODS: The current research paper is double-blinded, parallel designed clinical trial that was conducted in the Department of Periodontics and Oral Implantology, Kalinga Institute of Dental Sciences, Bhubaneswar. This included ninety dental students of Bachelor of Dental Surgery curriculum (in the age range from 20 to 24 years) Professional cleaning with scaling and polishing was carried out to acquire a zero plaque and gingival index (GI) for all ninety patients at baseline...
June 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28713109/comparative-evaluation-of-neem-mouthwash-on-plaque-and-gingivitis-a-double-blind-crossover-study
#11
Md Jalaluddin, U B Rajasekaran, Sam Paul, R S Dhanya, C B Sudeep, V J Adarsh
AIM: The present study aimed at evaluating the impact of neem-containing mouthwash on plaque and gingivitis. MATERIALS AND METHODS: This randomized, double-blinded, crossover clinical trial included 40 participants aged 18 to 35 years with washout period of 1 week between the crossover phases. A total of 20 participants, each randomly allocated into groups I and II, wherein in the first phase, group I was provided with 0.2% chlorhexidine gluconate and group II with 2% neem mouthwash...
July 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28710437/inhibition-of-ctgf-ameliorates-peritoneal-fibrosis-through-suppression-of-fibroblast-and-myofibroblast-accumulation-and-angiogenesis
#12
Norihiko Sakai, Miki Nakamura, Kenneth E Lipson, Taito Miyake, Yasutaka Kamikawa, Akihiro Sagara, Yasuyuki Shinozaki, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Yasunori Iwata, Miho Shimizu, Kengo Furuichi, Shuichi Kaneko, Andrew M Tager, Takashi Wada
Peritoneal fibrosis (PF) is a serious complication in various clinical settings, but the mechanisms driving it remain to be fully determined. Connective tissue growth factor (CTGF) is known to regulate fibroblast activities. We therefore examined if CTGF inhibition has anti-fibrotic effects in PF. PF was induced by repetitive intraperitoneal injections of chlorhexidine gluconate (CG) in mice with type I pro-collagen promoter-driven green fluorescent protein (GFP) expression to identify fibroblasts. FG-3019, an anti-CTGF monoclonal antibody, was used to inhibit CTGF...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28709990/in-vitro-development-of-an-effective-treatment-for-acanthamoeba-keratitis
#13
A Ortillés, J Belloc, E Rubio, M T Fernández, M Benito, J A Cristóbal, B Calvo, P Goñi
The aim of this study was to develop an in-vitro topical treatment for acanthamoeba keratitis (AK) effective against cysts and trophozoites. Qualitative assays were performed with voriconazole, chlorhexidine, propamidine, cellulase, tobramycin, ciprofloxacin and paromomycin as monotherapy and various combinations. Riboflavin with ultraviolet-A (R+UV-A) as monotherapy or combined with voriconazole and moxifloxacin was also tested. Quantitative assays to assess cyst viability after treatment were performed for the chemicals that showed the highest activity in the qualitative assays...
July 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28707889/gold-nanorod-mediated-chlorhexidine-microparticle-formation-and-near-infrared-light-induced-release
#14
Dong Luo, Md Samiul Hasan, Saroash Shahid, Boris Khlebtsov, Michael J Cattell, Gleb B Sukhorukov
Gold nanorods (GNR) are good light harvesting species for elaboration of near-infrared (NIR) responsive drug delivery systems. Herein, chlorhexidine microparticles are grown directly on the surface of gold nanorods and then stabilized with polyelectrolyte multilayer encapsulation, producing novel composite drug-GNR particles with high drug loading and NIR light sensitivity. Crystallization of chlorhexidine is caused by the ionic strength of the chloride solution that has been demonstrated via formation of a homogeneous porous spherical structure at 0...
July 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28706760/bactericidal-effect-of-different-anti-microbial-agents-on-fusobacterium-nucleatum-biofilm
#15
Rupa Ashok, Arathi Ganesh, Kandaswamy Deivanayagam
INTRODUCTION: The root canal anatomy of the teeth is very complex. Complete debridement of the root canals is a challenge and is very important for the success of the root canal treatment. Hence, this study was done to find an effective irrigant which can be used during root canal treatment. OBJECTIVE: The bactericidal effect of a potential root canal irrigant was compared with two commonly used root canal irrigants against monoculture biofilm of a commercially available isolate of Fusobacterium nucleatum...
June 11, 2017: Curēus
https://www.readbyqxmd.com/read/28706466/modeling-the-potential-impact-of-emerging-innovations-on-achievement-of-sustainable-development-goals-related-to-maternal-newborn-and-child-health
#16
Tara Herrick, Claudia Harner-Jay, Craig Shaffer, Greg Zwisler, Peder Digre, Amie Batson
BACKGROUND: Innovations that improve the affordability, accessibility, or effectiveness of health care played a major role in the Millennium Development Goal achievements and will be critical for reaching the ambitious new Sustainable Development Goal (SDG) health targets. Mechanisms to identify and prioritize innovations are essential to inform future investment decisions. METHODS: Innovation Countdown 2030 crowdsourced health innovations from around the world and engaged recognized experts to systematically assess their lifesaving potential by 2030...
2017: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/28704121/evaluation-of-in-vitro-antiamoebic-activity-of-antimicrobial-agents-against-clinical-acanthamoeba-isolates
#17
Hidemasa Nakaminami, Kentaro Tanuma, Kiichi Enomoto, Yukihiko Yoshimura, Tomoyo Onuki, Shin Nihonyanagi, Yukihiro Hamada, Norihisa Noguchi
PURPOSE: The aim of this study was to elucidate in vitro antiamoebic activity of antimicrobial agents at short exposure times similar to those used for actual treatment against Acanthamoeba strains isolated from patients with keratitis. METHODS: The 5 clinical Acanthamoeba isolated in Japan were used in this study. Identification of genotypes for the Acanthamoeba isolates was performed using partial 18S ribosomal DNA (rDNA), including the ASA.S1 region sequences...
July 13, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28703892/disinfection-of-the-peritoneal-dialysis-bag-medication-port-comparison-of-disinfectant-agent-and-disinfection-time
#18
Adriana Conti, Roberta Monteiro Katzap, Carlos Eduardo Poli-de-Figueiredo, Vany Pagnussatti, Ana Elizabeth Figueiredo
OBJECTIVE: To compare different disinfection techniques for the peritoneal dialysis bag medication port (MP). METHODS: An experimental study was conducted testing different cleaning agents (70% alcohol vs 2% chlorhexidine) and time periods (5, 10 and 60 seconds) for disinfection of the MP. Five microorganisms (S. aureus, E.coli, A. baumannii and C. parapsilosis, CNS) were prepared for use as contaminants of the MP. MP were incubated in Tryptic soy broth at 36 °C for 24 h, after which, they were seeded on a Biomérieux® blood agar plate and incubated for 24 h at 36 °C...
July 13, 2017: Nephrology
https://www.readbyqxmd.com/read/28701228/efficacy-of-umbilical-cord-cleansing-with-a-single-application-of-4-chlorhexidine-for-the-prevention-of-newborn-infections-in-uganda-study-protocol-for-a-randomized-controlled-trial
#19
Victoria Nankabirwa, Thorkild Tylleskär, Josephine Tumuhamye, James K Tumwine, Grace Ndeezi, José C Martines, Halvor Sommerfelt
BACKGROUND: Yearly, nearly all the estimated worldwide 2.7 million neonatal deaths occur in low- and middle-income countries. Infections, including those affecting the umbilical cord (omphalitis), are a significant factor in approximately a third of these deaths. In fact, the odds of all-cause mortality are 46% higher among neonates with omphalitis than in those without. Five large randomized controlled trials in Asia and Sub-Saharan Africa (SSA) have examined the effect of multiple cord stump applications with 4% chlorhexidine (CHX) for at least 7 days on the risk of omphalitis and neonatal death...
July 12, 2017: Trials
https://www.readbyqxmd.com/read/28701056/effects-of-polyhexamethylene-guanidine-phosphate-on-human-gingival-fibroblasts
#20
Anton Vitt, Veronica Slizen, Elisabeth A Boström, Tülay Yucel-Lindberg, Anna Kats, Rachael V Sugars, Anders Gustafsson, Kåre Buhlin
OBJECTIVE: Polyhexamethylene guanidine phosphate (PHMG-P) was compared to chlorhexidine (CHX) in order to determine potential cytotoxic and immune-modulatory effects on human gingival fibroblasts. MATERIALS AND METHODS: Cytotoxic effects of PHMG-P and CHX on human gingival fibroblasts were assessed using cell viability assay at various time points and concentrations. The effects of PHMG-P and CHX on the secretion of prostaglandin (PG) E2, interleukin (IL)-6, IL-8 and matrix metalloproteinase (MMP)-1 by non-stimulated or IL-1β stimulated fibroblasts were evaluated by enzyme-linked immunosorbent assays...
July 12, 2017: Acta Odontologica Scandinavica
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