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https://www.readbyqxmd.com/read/29776398/primary-bacterial-ventriculitis-in-adults-an-emergent-diagnosis-challenge-report-of-a-meningoccal-case-and-review-of-the-literature
#1
Anaïs Lesourd, Nicolas Magne, Anaïs Soares, Caroline Lemaitre, Muhamed-Kheir Taha, Isabelle Gueit, Michel Wolff, François Caron
BACKGROUND: Defined by an infection of the ventricular system of the brain, ventriculitis is usually known as a health-care associated infection. In contrast, primary pyogenic ventriculitis complicating community-acquired meningitis is uncommon, and mainly described in infants. Only seven cases that have occured in adults have been found in the international literature. CASE PRESENTATION: We report here a new case due to Neisseria meningitidis occurring in an 85 year-old-man...
May 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29775786/is-mic-increase-of-meropenem-against-klebsiella-pneumoniae-carbapenemase-kpc-producing-klebsiella-pneumoniae-correlated-with-the-increase-of-resistance-rates-against-some-other-antibiotics-with-gram-negative-activity
#2
Piergiorgio Cojutti, Assunta Sartor, Matteo Bassetti, Claudio Scarparo, Federico Pea
OBJECTIVE: To assess MIC distribution for meropenem and the other antibiotics with Gram-negative activity against KPC-Kp clinical isolates collected at our hospital in 2013-2016. METHODS: Susceptibility of KPC-Kp strains was tested by broth microdilution method, using customized 96-well plates, and was interpreted according to the EUCAST recommendations. RESULTS: Among 169 consecutive KPC-Kp clinical isolates 26.6% were susceptible to meropenem...
May 15, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29774093/distribution-of-virulence-associated-genes-and-antimicrobial-susceptibility-in-clinical-acinetobacter-baumannii-isolates
#3
Chao Liu, Yaowen Chang, Ying Xu, Yun Luo, Linrong Wu, Zhanjun Mei, Shigang Li, Rui Wang, Xu Jia
Acinetobacter baumannii is undoubtedly one of the most clinically significant pathogens. The multidrug resistance and virulence potential of A. baumannii are responsible for hospital-acquired nosocomial infections. Unlike numerous investigations on the drug-resistant epidemiology of A. baumanni , virulence molecular epidemiology is less studied. Here, we collected 88 A. baumannii clinical isolates, tested their antimicrobial susceptibility to 10 commonly used antibiotics and analyzed the distribution of 9 selected virulence-associated genes, aims to investigate the primary characteristics of the virulence-associated genes that exist in clinically multidrug resistant (MDR) and non-MDR isolates of A...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29771104/-appropriateness-of-antimicrobial-prescriptions-in-the-emergency-department-of-a-tertiary-hospital
#4
L Yunquera-Romero, I Márquez-Gómez, A Henares-López, M J Morales-Lara, C Gallego Fernández, R Asensi-Díez
OBJECTIVE: Antibiotics are widely prescribed in the Emergency Department (ED), representing 26-62% of outpatient antibiotic prescriptions. Around 40% of antibiotic prescriptions in hospitalized patients are inappropriate or unnecessary. The aim of the study was to assess the appropriateness of antibiotic prescriptions according to local empirical antibiotic treatment guidelines, in the ED of a tertiary hospital. METHODS: Observational, retrospective study including patients attending the ED in November 2016, with an antibiotic prescription, excluding those from residents...
May 16, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29765362/tachyplesin-causes-membrane-instability-that-kills-multidrug-resistant-bacteria-by-inhibiting-the-3-ketoacyl-carrier-protein-reductase-fabg
#5
Cunbao Liu, Jialong Qi, Bin Shan, Yanbing Ma
Tachyplesin is a type of cationic β-hairpin antimicrobial peptide discovered in horseshoe crab approximately 30 years ago that is well known for both its potential antimicrobial activities against multidrug-resistant bacteria and its cytotoxicity to mammalian cells. Though its physical interactions with artificial membranes have been well studied, details of its physiological mechanism of action the physiological consequences of its action remain limited. By using the DNA-binding fluorescent dye propidium iodide to monitor membrane integrity, confocal microscopy to assess the intracellular location of FITC-tagged tachyplesin, and RNA sequencing of the differentially expressed genes in four Gram-negative bacteria ( Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae , and Pseudomonas aeruginosa ) treated with lethal or sublethal concentrations of tachyplesin, we found that compared with levofloxacin-treated bacteria, tachyplesin-treated bacteria showed significant effects on the pathways underlying unsaturated fatty acid biosynthesis...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29754067/enantiomeric-impurity-analysis-using-circular-dichroism-spectroscopy-with-united-states-pharmacopeia-liquid-chromatographic-methods
#6
Douglas Kirkpatrick, Margaret Fain, Jingyue Yang, Michael Trehy
Over 300 chiral drug substances lack official United States Pharmacopeia (USP) methods for the enantiomeric purity determination. Because enantiomeric analysis typically requires specialized methods for each drug compound, developing protocols for each of these 300+ substances would be an expensive and laborious endeavor. Alternatively, if a detector capable of determining the enantiomeric composition without chiral separation could be used with certain drug compounds, this could be implemented relatively rapidly into official testing monographs...
April 24, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29750801/streptococcus-agalactiae-carriage-among-pregnant-women-living-in-rio-de-janeiro-brazil-over-a-period-of-eight-years
#7
Ana Caroline N Botelho, Juliana G Oliveira, Andreia P Damasco, Késia T B Santos, Ana Flávia M Ferreira, Gabriel T Rocha, Penélope S Marinho, Rita B G Bornia, Tatiana C A Pinto, Marco A Américo, Sergio E L Fracalanzza, Lúcia M Teixeira
Group B Streptococcus (GBS) carriage by pregnant women is the primary risk factor for early-onset GBS neonatal sepsis. Intrapartum antibiotic prophylaxis (IAP) can prevent this transmission route, and two main approaches are recommended to base the selection of pregnant women to be submitted to IAP: the risk-based and the culture-based strategies. In Brazil, compliance to such recommendations is poor, and not much is known about GBS carriage. In the present study, 3,647 pregnant women living in Rio de Janeiro State, Brazil, were screened for GBS anogenital colonization, over a period of 8 years (2008-2015)...
2018: PloS One
https://www.readbyqxmd.com/read/29750587/the-microbiologic-profile-of-dacryocystitis
#8
Stella Y Chung, Leon Rafailov, Roger E Turbin, Paul D Langer
PURPOSE: Recent studies suggest an increasing incidence of gram-negative bacteria and methicillin-resistant Staphylococcus aureus in dacryocystitis. Since patients are often treated empirically without culture data, a changing microbiologic profile will markedly affect the success of oral treatment. To provide current guidelines for the treatment of this common condition, we investigated the microbiology and antibiogram of dacryocystitis seen at our institution. METHODS: The charts of all patients presenting with acute and/or chronic dacryocystitis in University Hospital, Newark, from 2007 to 2015 were reviewed...
May 11, 2018: Orbit
https://www.readbyqxmd.com/read/29748091/development-and-validation-of-a-hydrophilic-interaction-liquid-chromatography-tandem-mass-spectrometry-method-for-the-quantification-of-the-antidiabetic-drug-metformin-and-six-others-pharmaceuticals-in-wastewater
#9
Reinhard Oertel, Julien Baldauf, Julia Rossmann
A rapid and sensitive hydrophilic interaction liquid chromatography (HILIC)-tandem mass spectrometry method was developed and fully validated for the simultaneous determination of the antidiabetic drug metformin and six further pharmaceuticals (atenolol, gabapentin, levofloxacin, ciprofloxacin, propranolol and trimethoprim) in influent and effluent wastewater. Five deuterated related compounds were used as internal standards in order to control the extraction, injection and ionization variability. Two solid phase extraction methods and Oasis HLB 1cc cartridge, using only 1 mL sample with acid or basic pH-value were optimized and compared in order to match the specificity of both influent and effluent wastewater matrixes...
May 4, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29747008/determination-of-gyra-and-parc-mutations-and-prevalence-of-plasmid-mediated-quinolone-resistance-genes-in-escherichia-coli-and-klebsiella-pneumoniae-isolated-from-patients-with-uti-in-iran
#10
Mehdi Mirzaii, Sanaz Jamshidi, Maryam Zamanzadeh, Masoud Marashifard, Seyed Ali Asghar Malek Hosseini, Mehri Haeili, Fariba Jahanbin, Fariba Mansouri, Davood Darban-Sarokhalil, Seyed Sajjad Khoramrooz
BACKGROUND: Fluoroquinolones (FQs) are recommended as the drug of choice for the empirical treatment of urinary tract infections (UTIs).We aimed to investigate the molecular determinants of FQ resistance in Escherichia coli and Klebsiella pneumoniae isolates. METHODS: A total of 364 clinical isolates of E. coli (n=144) and K. pneumoniae (n=220) were collected from patients with UTI. Susceptibility of the isolates to ciprofloxacin, levofloxacin, gatifloxacin and nalidixic acid was evaluated by using disc diffusion method...
May 7, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29745242/comparative-in-vitro-antibacterial-activity-of-ozenoxacin-against-gram-positive-clinical-isolates
#11
Rafael Canton, Ian Morrissey, Jordi Vila, Marta Tato, María García-Castillo, Yuly López, Domingo Gargallo-Viola, Ilonka Zsolt
AIM: To compare the in vitro activity of the anti-impetigo agent, ozenoxacin, and other antimicrobial agents against Gram-positive clinical isolates from skin and soft tissue infections. MATERIALS & METHODS: Isolates were collected in two studies: 1097 isolates from 49 centers during 2009-2010 and 1031 isolates from ten centers during 2014. Minimum inhibitory concentrations were determined for 18 and 11 antimicrobials in these studies, respectively, using standard broth microdilution methods...
May 1, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29735844/observation-of-a-new-pattern-of-mutations-in-gyra-and-parc-within-escherichia-coli-exhibiting-fluroquinolone-resistance
#12
Nivedita Dasgupta, Deepjyoti Paul, Debadatta Dhar Chanda, Shiela Chetri, Atanu Chakravarty, Amitabha Bhattacharjee
Therapeutic options with quinolones are severely compromised in infections caused by members of Enterobacteriaceae family. Mutations in chromosomal region are one of the major reasons for bacterial resistance towards this group of antibiotic. The aim of the study is to detect the mutations in gyr A and par C responsible for quinolone resistance among clinical isolates of Escherichia coli. A total of 96 quinolone-resistant clinical isolates of E. coli were collected from a tertiary care hospital of North-east India during March 2015 to August 2015...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29735830/changing-trends-of-culture-positive-typhoid-fever-and-antimicrobial-susceptibility-in-a-tertiary-care-north-indian-hospital-over-the-last-decade
#13
Priyanka Sharma, Sushila Dahiya, Neelam Manral, Bhavana Kumari, Sambuddha Kumar, Sangeeta Pandey, Seema Sood, Bimal Kumar Das, Arti Kapil
Purpose: The present study was undertaken to analyse the trend in prevalence of culture-positive typhoid fever during the last decade and to determine antimicrobial susceptibility profile of Salmonella Typhi and Salmonella Paratyphi A isolated from patients of enteric fever presenting to our hospital. Methods: All the culture-positive enteric fever cases during 2005-2016 presenting to our Hospital were included in the study. Antimicrobial susceptibility was done against chloramphenicol, amoxicillin, co-trimoxazole, ciprofloxacin, ofloxacin, levofloxacin, pefloxacin, ceftriaxone and azithromycin as per corresponding CLSI guidelines for each year...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29729161/antimicrobial-susceptibility-patterns-of-escherichia-coli-in-children-and-adults-with-urinary-tract-infections
#14
Yaroslav O Mykhalko
OBJECTIVE: Introduction: Urinary tract infections (UTIs) are common pathology in children and adults that is caused mainly by Gram-negative bacteria among which Escherichia coli plays an outstanding role. UTIs treatment demands empiric antibiotic therapy and knowing of antimicrobial local susceptibility and resistance patterns is crucial for making a decision about an agent for the first line therapy. The aim of this study was to evaluate the local susceptibility patterns of uropathogenic E...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29729160/-dynamics-of-staphylococcus-aureus-antibiotic-resistance-to-fluoroquinolones-in-vitro-in-patients-with-overweight
#15
Tetiana V Dukhovich, Ivan V Chopei, Kseniya I Chubirko
OBJECTIVE: Introduction:S. aureus is the main pathogen of skin, soft tissue and otorhinolaryngological infections as well as the cause of osteomyelitis, meningitis and endocarditis. In recent years the importance of S. aureus mediated infections has grown not only because of their widespread, but also due to their antibiotic resistance. Recent observations showed that the resistance is developed to each new antibacterial agent after 5 years of its intensive use. Based on the studies conducted in Ukraine, it is known that the resistance of S...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29719745/acute-acalculous-cholecystitis-in-the-setting-of-negative-ultrasound-and-computed-tomography-scan-of-the-abdomen
#16
Muhammad Shafiq, Yousaf Zafar
Acute acalculous cholecystitis (AAC) is most commonly seen after surgery in critically ill patients. Early diagnosis and treatment is the key in the management of AAC. Ultrasound is the commonly used first modality for right upper quadrant (RUQ) pain with sensitivity equal to or greater than 80% for AAC. Computed tomography (CT) scan is reported to have a sensitivity close to 90% and if both the ultrasound and CT scan are combined, it further increases the sensitivity for the diagnosis of AAC. It is unlikely for AAC to be present in the setting of both negative ultrasound and CT scan of the abdomen...
February 28, 2018: Curēus
https://www.readbyqxmd.com/read/29718896/salmonella-potsdam-causing-lumbar-vertebral-osteomyelitis-a-case-report
#17
Weike Cheng, Kejian Lian, Deqing Luo, Dasheng Lin, Wanqiang Feng, Hang Xian, Tongtao Li
RATIONALE: Salmonella osteomyelitis is an uncommon complication of salmonella infection, especially the salmonella vertebral osteomyelitis (SVO). PATIENT CONCERNS: We reported a case of a 29-year-old female who presented with serious lower back pain and severe limitation of motion for 50 days with no obvious inducements. She once had a fever up to 39.5°C. Physical examination only revealed limited motion of lower back without neurological complications. The laboratory results revealed no specificity...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29716812/first-report-of-the-isolation-of-bla-imi-1-producing-colistin-heteroresistant-enterobacter-cloacae-in-japan-september-2016
#18
Norihito Tarumoto, Masahiro Kodana, Noriyuki Watanabe, Jun Sakai, Kazuo Imai, Toshiyuki Yamaguchi, Yoshitada Taji, Yasuhiro Ebihara, Takashi Murakami, Takuya Maeda, Kotaro Mitsutake, Shigefumi Maesaki
The isolation of a carbapenem-resistant Enterobacter cloacae strain harboring the IMI-1 variant of blaIMI-1 carbapenemase points to the worldwide emergence of multidrug resistant bacteria as a potential source of health care infections. In this report, we describe the first isolation of E. cloacae with blaIMI-1 carbapenemase isolated from a Japanese patient in September 2016. The isolate was resistant to carbapenems, levofloxacin, and aminoglycosides, and heteroresistant to colistin but sensitive to fourth-generation cephalosporins...
April 28, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29709668/facile-green-synthetic-graphene-based-co-fe-prussian-blue-analogues-as-an-activator-of-peroxymonosulfate-for-the-degradation-of-levofloxacin-hydrochloride
#19
Yunqing Pi, Lingjia Ma, Peng Zhao, Yangdan Cao, Huiqin Gao, Chunfeng Wang, Qilu Li, Shuying Dong, Jianhui Sun
A kind of Co-Fe Prussian blue analogues (Co-Fe PBAs), cobalt hexacyanoferrate Co3 [Fe(CN)6 ]2 , and graphene oxide (GO) were combined to synthesize magnetically separable Co-Fe PBAs@rGO nanocomposites through a simple two-step hydrothermal method. The crystalline structure, morphology and textural properties of the Co-Fe PBAs@rGO nanocomposites were characterized. The catalytic performance of the nanocomposites was evaluated by PMS activation, with Levofloxacin Hydrochloride (LVF) as the target contaminant...
April 18, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29707286/-in-vitro-assessment-of-cefoperazone-sulbactam-based-combination-therapy-for-multidrug-resistant-acinetobacter-baumannii-isolates-in-china
#20
Tao Li, Meiyan Sheng, Tengzhen Gu, Yan Zhang, Ailiyaer Yirepanjiang, Yu Li
Background: Multidrug-resistant Acinetobacter baumannii (MDRAB) has emerged as an important pathogen of nosocomial infections. Even though cefoperazone-sulbactam is frequently used to treat MDRAB infections, this single-drug therapeutic approach often results in antibiotic resistance. Thus, combination therapy is preferred over single-drug therapy, particularly in the case of carbapenemase-producing gram negative bacteria. The aim of this study was to investigate the efficacy of cefoperazone-sulbactam combined with either tigecycline or rifampicin against clinical isolates of MDRAB...
March 2018: Journal of Thoracic Disease
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