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https://www.readbyqxmd.com/read/29449793/clinical-proteomic-analysis-of-scrub-typhus-infection
#1
Edmond Changkyun Park, Sang-Yeop Lee, Sung Ho Yun, Chi-Won Choi, Hayoung Lee, Hyun Seok Song, Sangmi Jun, Gun-Hwa Kim, Chang-Seop Lee, Seung Il Kim
Background: Scrub typhus is an acute and febrile infectious disease caused by the Gram-negative α-proteobacterium Orientia tsutsugamushi from the family Rickettsiaceae that is widely distributed in Northern, Southern and Eastern Asia. In the present study, we analysed the serum proteome of scrub typhus patients to investigate specific clinical protein patterns in an attempt to explain pathophysiology and discover potential biomarkers of infection. Methods: Serum samples were collected from three patients (before and after treatment with antibiotics) and three healthy subjects...
2018: Clinical Proteomics
https://www.readbyqxmd.com/read/29431689/dysregulated-th1-immune-and-vascular-responses-in-scrub-typhus-pathogenesis
#2
REVIEW
Lynn Soong
Scrub typhus is an emerging, insect-transmitted disease caused by Orientia tsutsugamushi, a Gram- and LPS-negative bacterium that replicates freely within professional phagocytes and endothelial cells. Scrub typhus is prevalent with high mortality rates, but information regarding its molecular pathogenesis, microbial virulence determinants, and key immune responses is limited. Improved animal models have recently been developed that respectively resemble the pathological features of self-limiting or severe scrub typhus in humans...
February 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29430404/spectrum-of-cardiac-manifestations-and-its-relationship-to-outcomes-in-patients-admitted-with-scrub-typhus-infection
#3
Gunasekaran Karthik, Thomas Isaiah Sudarsan, John Victor Peter, Thambu Sudarsanam, George M Varghese, Paul Kundavaram, Sowmya Sathyendra, Ramya Iyyadurai, Kishore Pichamuthu
AIM: To study the spectrum of cardiac manifestations in scrub typhus infection and assess its relationship to outcomes. METHODS: Demographic data, electrocardiographic (ECG) changes, left ventricular (LV) systolic and diastolic function, myocardial injury (defined as troponin T > 14 pg/mL), and pericardial effusion were documented. Myocarditis was diagnosed when myocardial injury was associated with global LV systolic dysfunction. The relationship between myocarditis and outcomes was assessed using logistic regression analysis and expressed as odds ratio (OR) with 95%CI...
February 4, 2018: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29405137/spectrum-of-infections-in-acute-febrile-illness-in-central-india
#4
Yogendra Pandurang Shelke, Vijayshri Suresh Deotale, Deepashri Laxmanrao Maraskolhe
INTRODUCTION: Infectious agent when enters in the host results in febrile illness. This may lead to increase in morbidity or even mortality in undiagnosed/untreated cases. There are many aetiological agents which lead to acute febrile illness. Among these aetiological agents, important is bacterial or viral aetiology. OBJECTIVE: The objective of this study is: (i) To know the aetiological agents responsible for acute undifferentiated febrile illness (AUFI) by serological test or by bacterial culture and (ii) To know the clinical profile of AUFI...
October 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29396933/comparison-of-scrub-typhus-meningitis-with-acute-bacterial-meningitis-and-tuberculous-meningitis
#5
Svas Raju Kakarlapudi, Anila Chacko, Prasanna Samuel, Valsan Philip Verghese, Winsley Rose
OBJECTIVE: To compare scrub typhus meningitis with bacterial and tuberculous meningitis. METHODS: Children aged <15 years admitted with meningitis were screened and those who fit criteria for diagnosis of scrub typhus meningitis (n=48), bacterial meningitis (n=44) and tuberculous meningitis (n=31) were included for analysis. Clinical features, investigations and outcomes were compared between the three types of meningitis. RESULTS: Mean age, duration of fever at presentation, presence of headache and, altered sensorium and presence of hepatomegaly/splenomegaly were statistically significantly different between the groups...
January 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29396931/scrub-typhus-meningitis-versus-acute-bacterial-meningitis-and-tuberculous-meningitis
#6
Stalin Viswanathan
No abstract text is available yet for this article.
January 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29390021/development-of-a-loop-mediated-isothermal-amplification-lamp-assay-for-rapid-screening-of-ticks-and-fleas-for-spotted-fever-group-rickettsia
#7
Bruce H Noden, Jaclyn Martin, Yisel Carrillo, Justin L Talley, Francisco M Ochoa-Corona
BACKGROUND: The importance of tick and flea-borne rickettsia infections is increasingly recognized worldwide. While increased focus has shifted in recent years to the development of point-of-care diagnostics for various vector-borne diseases in humans and animals, little research effort has been devoted to their integration into vector surveillance and control programs, particularly in resource-challenged countries. One technology which may be helpful for large scale vector surveillance initiatives is loop-mediated isothermal amplification (LAMP)...
2018: PloS One
https://www.readbyqxmd.com/read/29386235/an-update-on-host-pathogen-interplay-and-modulation-of-immune-responses-during-orientia-tsutsugamushi-infection
#8
REVIEW
Fabián E Díaz, Katia Abarca, Alexis M Kalergis
The obligate intracellular bacterium Orientia tsutsugamushi is the causative agent of scrub typhus in humans, a serious mite-borne disease present in a widespread area of endemicity, which affects an estimated 1 million people every year. This disease may exhibit a broad range of presentations, ranging from asymptomatic to fatal conditions, with the latter being due to disseminated endothelial infection and organ injury. Unique characteristics of the biology and host-pathogen interactions of O. tsutsugamushi , including the high antigenic diversity among strains and the highly variable, short-lived memory responses developed by the host, underlie difficulties faced in the pursuit of an effective vaccine, which is an imperative need...
April 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29374896/-epidemiology-of-scrub-typhus-and-influencing-factors-in-yunnan-province-2006-2013
#9
Y Sun, C Shi, X L Li, L Q Fang, W C Cao
Objective: To understand the epidemiological characteristics of scrub typhus and influencing factors in Yunnan province, and provide further information for the prevention and control of scrub typhus. Methods: Based on the incidence data of scrub typhus reported in Yunnan from 2006 to 2013, the epidemiological characteristics of scrub typhus were analyzed and related environmental factors were identified with panel negative binomial regression model. Results: A total of 8 980 scrub typhus cases were reported during 2006-2013 in Yunnan...
January 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29370684/epidemiologic-characteristics-of-scrub-typhus-on-jeju-island
#10
Jong-Myon Bae
No abstract text is available yet for this article.
December 26, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/29368107/predictors-of-severity-in-pediatric-scrub-typhus
#11
Dinesh Kumar Narayanasamy, Thirunavukkarasu Arun Babu, Vijayasankar Vijayadevagaran, Devi Kittu, Shanthi Ananthakrishnan
OBJECTIVE: To identify the factors that can predict the severity of scrub typhus in children. METHODS: This prospective study was conducted at a tertiary care teaching hospital between November 2014 to October 2016. All children <12y of age admitted with fever for more than 7d and positive IgM ELISA for scrub typhus were included in the study. These children were followed during the hospital course and their laboratory results, response to treatment and complications were documented...
January 24, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29358295/orientia-tsutsugamushi-is-highly-susceptible-to-the-rna-polymerase-switch-region-inhibitor-corallopyronin-a-in-vitro-and-in-vivo
#12
Fredericke Kock, Matthias Hauptmann, Anke Osterloh, Till F Schäberle, Sven Poppert, Hagen Frickmann, Klaus-Dieter Menzel, Gundela Peschel, Kenneth Pfarr, Andrea Schiefer, Gabriele M König, Achim Hoerauf, Bernhard Fleischer, Christian Keller
Scrub typhus is a potentially lethal infection caused by the obligate intracellular bacterium Orientia (O.) tsutsugamushi Reports on the emergence of doxycycline-resistant strains highlight the urgent need to develop novel anti-infectives against scrub typhus.Corallopyronin A (CorA) is a novel α-pyrone compound synthesized by the myxobacterium Corallococcus coralloides and was characterized as a non-competitive inhibitor of the "switch region" of bacterial RNA polymerase (RNAP). We investigated the antimicrobial action of CorA against the human-pathogenic Karp strain of O...
January 22, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29350608/acute-transverse-myelitis-following-scrub-typhus-a-case-report-and-review-of-the-literature
#13
Hyun-Seung Ryu, Bong Ju Moon, Jae-Young Park, Sang-Deok Kim, Seung-Kwon Seo, Jung-Kil Lee
Context Scrub typhus is an acute febrile disease caused by Orientia tsutsugamushi. The disease can usually involve the lungs, heart, liver, spleen and brain through hematogenous dissemination. However, very rarely, acute transverse myelitis in the spinal cord develops from scrub typhus. We present a case of acute transverse myelitis following scrub typhus with a review of the literature. Findings A 66-year-old male visited a hospital for general myalgia, mild headache, and fever in October. He was noted to have thick, black papule skin on his abdomen, which was highly suggestive of scrub typhus...
January 19, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29350148/scrub-typhus-outbreak-in-chonburi-province-central-thailand-2013
#14
Wuttikon Rodkvamtook, Narupon Kuttasingkee, Piyada Linsuwanon, Yutthapong Sudsawat, Allen L Richards, Maneerat Somsri, Noppadon Sangjun, Chien-Chung Chao, Silas Davidson, Elizabeth Wanja, Jariyanart Gaywee
Investigation of a scrub typhus outbreak in Thailand during September 2013 found that 9.1% of Thai soldiers and 11.1% of residents living in areas surrounding training sites had antibodies against the causative agent, Orientia tsutsugamushi. Sequence analysis of O. tsutsugamushi from rodents and chiggers identified 7 genogroups and 3 genotypes.
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29346369/the-rise-of-neglected-tropical-diseases-in-the-new-texas
#15
REVIEW
Peter J Hotez
Within the last five years, the State of Texas has experienced either transmission or outbreaks of Ebola, chikungunya, West Nile, and Zika virus infections. Autochthonous transmission of neglected parasitic and bacterial diseases has also become increasingly reported. The rise of such emerging and neglected tropical diseases (NTDs) has not occurred by accident but instead reflects rapidly evolving changes and shifts in a "new" Texas beset by modern and globalizing forces that include rapid expansions in population together with urbanization and human migrations, altered transportation patterns, climate change, steeply declining vaccination rates, and a new paradigm of poverty known as "blue marble health...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29313468/molecular-epidemiology-of-an-orientia-tsutsugamushi-gene-encoding-a-56-kda-type-specific-antigen-in-chiggers-small-mammals-and-patients-from-the-southwest-region-of-korea
#16
Jung Wook Park, Sun Hee Kim, Duck Woong Park, So Hyang Jung, Hye Jung Park, Mi Hee Seo, Hyeon Je Song, Jung Yoon Lee, Dong Min Kim, Choon Mi Kim, Byong Chul Gill, Hang Jin Jeong, Jeong Min Lee, Dong Ryong Ha, Eun Sun Kim, Jae Keun Chung
A phylogenetic analysis of Orientia tsutsugamushi was performed to elucidate its antigenic diversity in chiggers, small mammals, and patients. Between September 2014 and December 2016, a total of 3,816 chiggers were identified within nine species of four genera in the southwest region of Korea: Leptotrombidium scutellare (49.9%; 1,907/3,816), Leptotrombidium orientale (21.1%; 804/3,816), Leptotrombidium pallidum (12.4%; 474/3,816), Euchoengastia koreaensis (7.2%; 273/3,816), Leptotrombidium palpale (6.7%; 256/3,816), Neotrombicular gardellai (1...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29309171/-red-cross-war-hospital-in-rijeka-1914-1918
#17
Zorica Manojlović
The article describes how the system of medical care for wounded soldiers in Rijeka during the First World War was organized. In the Austro-Hungarian Empire the hospital care for sick and wounded soldiers, except of a military health care, was under the exclusive jurisdiction of the Red Cross. The Municipal Committee of the Hungarian Red Cross in Rijeka, established in 1881, renewed its previously suspended activity in August 1914, with the task of starting a war hospital for wounded soldiers. For this purpose, the former Hotel for emigrants, a large modern building opened in 1908, was converted...
December 2017: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/29307960/tropical-fevers-in-indian-intensive-care-units-a-prospective-multicenter-study
#18
Sunit Singhi, Narendra Rungta, Karthi Nallasamy, Ashish Bhalla, J V Peter, Dhruva Chaudhary, Rajesh Mishra, Prakash Shastri, Rajesh Bhagchandani, T D Chugh
Background and Aims: Infections in tropics often present as undifferentiated fevers with organ failures. We conducted this nationwide study to identify the prevalence, profile, resource utilization, and outcome of tropical fevers in Indian Intensive Care Units (ICUs). Materials and Methods: This was a multicenter prospective observational study done in 34 ICUs across India (July 2013-September 2014). Critically ill adults and children with nonlocalizing fever >48 h and onset < 14 days with any of the following: thrombocytopenia/rash, respiratory distress, renal failure, encephalopathy, jaundice, or multiorgan failure were enrolled consecutively...
December 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29259327/longevity-of-antibody-and-t-cell-responses-against-outer-membrane-antigens-of-orientia-tsutsugamushi-in-scrub-typhus-patients
#19
Na-Young Ha, Yuri Kim, Chan-Ki Min, Hong-Il Kim, Nguyen Thi Hai Yen, Myung-Sik Choi, Jae-Seung Kang, Yeon-Sook Kim, Nam-Hyuk Cho
Scrub typhus, caused by Orientia tsutsugamushi infection, has been a serious public health issue in the Asia-Pacific region, with rising incidence and sporadic outbreaks. However, human protective immunity against specific antigens has been poorly characterized for this bacterium. In addition, immunity produced in early vaccine trials or even after natural infections, did not last long and had poor cross-reactivity among various genotypes. Here, we systematically investigated the kinetics and magnitude of specific adaptive immunity against two membrane antigens, 56 kDa type-specific antigen (TSA56) and surface cell antigen A (ScaA), that are involved in bacterial adhesion and invasion of the host in 64 recovered scrub typhus patients...
December 20, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29247906/long-term-monitoring-of-breath-methane
#20
Daniela Polag, Frank Keppler
In recent years, methane as a component of exhaled human breath has been considered as a potential bioindicator providing information on microbial activity in the intestinal tract. Several studies indicated a relationship between breath methane status and specific gastrointestinal disease. So far, almost no attention has been given to the temporal variability of breath methane production by individual persons. Thus here, for the first time, long-term monitoring was carried out measuring breath methane of three volunteers over periods between 196 and 1002days...
December 13, 2017: Science of the Total Environment
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