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https://www.readbyqxmd.com/read/29217880/renal-manifestation-in-scrub-typhus-during-a-major-outbreak-in-central-nepal
#1
A Sedhain, G R Bhattarai
Renal involvement and acute kidney injury (AKI) are common clinical manifestations seen in scrub typhus, a vector-borne tropical disease. There are no data on renal manifestation in scrub typhus in Nepal. We conducted a prospective study to analyze the incidence, urinary abnormalities, course, severity, outcome, and the predictors of AKI in patients with scrub typhus during a major outbreak in Central Nepal. Total 1398 patients admitted with acute febrile illness were subjected for Scrub Typhus Detect™ Immunoglobulin M (IgM) enzyme-linked immunosorbent assay (ELISA) test, of which 502 (35...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29208659/rapid-diagnosis-of-tick-borne-illnesses-by-use-of-one-step-isothermal-nucleic-acid-amplification-and-bio-optical-sensor-detection
#2
Ji Yeun Kim, Bonhan Koo, ChoongEun Jin, Min Chul Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Yong Shin, Sung-Han Kim
BACKGROUND: Scrub typhus and severe fever with thrombocytopenia syndrome (SFTS) are the most common tick-borne illnesses in South Korea. Early differentiation of SFTS from scrub typhus in emergency departments is essential but difficult because of their overlapping epidemiology, shared risk factors, and similar clinical manifestations. METHODS: We compared the diagnostic performance of one-step isothermal nucleic acid amplification with bio-optical sensor detection (iNAD) under isothermal conditions, which is rapid (20-30 min), with that of real-time PCR, in patients with a confirmed tick-borne illness...
December 5, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29207762/guillain-barre-syndrome-with-falciparum-malaria-and-scrub-typhus-mixed-infection-an-unusual-combination
#3
Rahul Sai Gangula, Weena Stanley, Arunsheshu Vandanapu, M Mukhyaprana Prabhu
Guillain-Barre Syndrome is very rare in parasitic and rickettsial infection. Here we report a case of Plasmodium falciparum and scrub typhus mixed infection, presented with quadriparesis. Clinical, Serological, CSF analysis and Nerve Conduction Studies were consistent with Acute Inflammatory Demyelinating Polyneuropathy (variant of GBS). After administration of antimalarials and antibiotics for the mixed infection, patient gradually improved.
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29200167/a-severe-case-of-murine-typhus-presenting-with-anemia-and-severe-thrombocytopenia
#4
Jade Wulff, Judith Margolin, Nana E Coleman, Gail Demmler-Harrison, Fong Lam, Mona D Shah
We discuss a child with severe thrombocytopenia and mild anemia admitted to the Hematology service who quickly deteriorated to a life-threatening state. However, once rickettsial disease was considered in the differential diagnosis and empiric doxycycline begun, she quickly and fully recovered. A diagnostic panel, including Rickettsia typhi serology, confirmed the diagnosis of murine typhus but this occurred weeks after she had recovered. Given the potential severity of rickettsial diseases and the ease of modern travel across geographic borders, hematology-oncology providers everywhere must consider rickettsial diseases in their differential diagnosis of critically ill children and begin empiric therapy with doxycycline promptly...
December 1, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29176880/seroprevalence-of-rickettsial-infections-and-q-fever-in-bhutan
#5
Tshokey Tshokey, John Stenos, David N Durrheim, Keith Eastwood, Chelsea Nguyen, Stephen R Graves
BACKGROUND: With few studies conducted to date, very little is known about the epidemiology of rickettsioses in Bhutan. Due to two previous outbreaks and increasing clinical cases, scrub typhus is better recognized than other rickettsial infections and Q fever. METHODOLOGY: A descriptive cross-sectional serosurvey was conducted from January to March 2015 in eight districts of Bhutan. Participants were 864 healthy individuals from an urban (30%) and a rural (70%) sampling unit in each of the eight districts...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29173047/epidemiological-clinical-and-laboratory-profile-of-scrub-typhus-cases-detected-by-serology-and-rt-pcr-in-kumaon-uttarakhand-a-hospital-based-study
#6
Vinita Rawat, Rajesh Kumar Singh, Ashok Kumar, Sandip R Saxena, Umesh Varshney, Mukesh Kumar
We analysed the epidemiology, clinical and laboratory data of the 168 scrub typhus cases confirmed by a combination of any one of the following: reverse transcription polymerase chain reaction (RT-PCR) and/or immunofluorescence assay (IFA) (IgM and/or IgG). The peak season for scrub typhus is from July to October. By multivariate binary logistic regression analysis, the risk of scrub typhus was about four times in those working in occupation related to forest work. Major clinical manifestations were fever (100%), myalgia (65%), cough (51%) and vomiting (46%); major complications were meningitis/meningoencephatilitis (12...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/29148369/newly-recognized-pediatric-cases-of-typhus-group-rickettsiosis-houston-texas-usa
#7
Timothy Erickson, Juliana da Silva, Melissa S Nolan, Lucila Marquez, Flor M Munoz, Kristy O Murray
An increase in typhus group rickettsiosis and an expanding geographic range occurred in Texas, USA, over a decade. Because this illness commonly affects children, we retrospectively examined medical records from 2008-2016 at a large Houston-area pediatric hospital and identified 36 cases. The earliest known cases were diagnosed in 2011.
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29137528/scrub-typhus-reinfection
#8
Munegowda C Koralur, Rahul Singh, Muralidhar Varma, John Stenos, Indira Bairy
No abstract text is available yet for this article.
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/29126839/the-epidemic-typhus-and-trench-fever-are-risk-for-public-health-due-to-increased-migration-in-southeast-of-turkey
#9
Nilgün Ulutasdemir, Fadime Eroglu, Mustafa Tanrıverdi, Eda Icbay Dagli, Ismail Soner Koltas
Pediculus humanus capitis is a small ectoparasitic insect that has lived and feds on human beings for thousands of years. Molecular techniques have been used for Pediculus species identification and evolutionary, phylogenic, and ecological studies. A total of 23 adults of P. h. capitis were collected in Gaziantep, located in southeast Turkey, and DNA was isolated from all P. h. capitis using DNA extraction kit. All DNA samples were screened for investigate of Ricettsia prowazekii, Bartonella quintana and Borrelia recurrentis with real-time polymerase chain reaction...
November 7, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29121711/differences-in-agricultural-activities-related-to-incidence-of-scrub-typhus-between-korea-and-japan
#10
Gyung-Jae Oh, Chang-Jin Ma, Gong-Unn Kang, Jeong-Mi Lee, Da-Un Lee, Hae-Sung Nam, So-Yeon Ryu, Young-Hoon Lee
Objectives: The purpose of this study is to establish a basis for improving or strengthening the preventive strategy against scrub typhus in Korea by comparing and analyzing the difference of prevention behaviors contributing to the occurrence of scrub typhus in both countries. Methods: The survey area selected Jeonbuk province, which is a high risk and high incidence area, and Fukuoka prefecture, which is a high risk and low incidence area. The subjects were 406 in Korea and 216 in Japanese farmers...
November 9, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/29111373/rickettsia-spp-among-wild-mammals-and-their-respective-ectoparasites-in-pantanal-wetland-brazil
#11
Keyla Carstens Marques de Sousa, Heitor Miraglia Herrera, Fabiana Lopes Rocha, Francisco Borges Costa, Thiago Fernandes Martins, Marcelo Bahia Labruna, Rosangela Zacarias Machado, Marcos Rogério André
The genus Rickettsia comprises obligatory intracellular bacteria, well known to cause zoonotic diseases around the world. The present work aimed to investigate the occurrence of Rickettsia spp. in wild animals, domestic dogs and their respective ectoparasites in southern Pantanal region, central-western Brazil, by molecular and serological techniques. Between August 2013 and March 2015, serum, whole blood and/or spleen samples were collected from 31 coatis, 78 crab-eating foxes, seven ocelots, 42 dogs, 110 wild rodents, and 30 marsupials...
October 27, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29109174/orientia-tsutsugamushi-modulates-endoplasmic-reticulum-associated-degradation-to-benefit-its-growth
#12
Kyle G Rodino, Lauren VieBrock, Sean M Evans, Hong Ge, Allen L Richards, Jason A Carlyon
Orientia tsutsugamushi, an obligate intracellular bacterium that is auxotrophic for the aromatic amino acids and histidine, causes scrub typhus, a potentially deadly infection that threatens one billion people. O. tsutsugamushi growth is minimal during the first 24 to 48 h of infection, but becomes logarithmic thereafter. How the pathogen modulates cellular functions to support its growth is poorly understood. The unfolded protein response (UPR) is a cytoprotective pathway that relieves endoplasmic reticulum (ER) stress by promoting ER-associated degradation (ERAD) of misfolded proteins...
November 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29103271/chigger-mite-acari-trombiculidae-survey-of-rodents-in-shandong-province-northern-china
#13
Xiao-Dan Huang, Peng Cheng, Yu-Qiang Zhao, Wen-Juan Li, Jiu-Xu Zhao, Hong-Mei Liu, Jing-Xuan Kou, Mao-Qing Gong
Chigger mites are parasites of rodents and other vertebrates, invertebrates, and other arthropods, and are the only vectors of scrub typhus, in addition to other zoonoses. Therefore, investigating their distribution, diversity, and seasonal abundance is important for public health. Rodent surveillance was conducted at 6 districts in Shandong Province, northern China (114-112°E, 34-38°N), from January to December 2011. Overall, 225/286 (78.7%) rodents captured were infested with chigger mites. A total of 451 chigger mites were identified as belonging to 5 most commonly collected species and 3 genera in 1 family...
October 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29099844/a-review-of-the-global-epidemiology-of-scrub-typhus
#14
REVIEW
Guang Xu, David H Walker, Daniel Jupiter, Peter C Melby, Christine M Arcari
Scrub typhus is a serious public health problem in the Asia-Pacific area. It threatens one billion people globally, and causes illness in one million people each year. Caused by Orientia tsutsugamushi, scrub typhus can result in severe multiorgan failure with a case fatality rate up to 70% without appropriate treatment. The antigenic heterogeneity of O. tsutsugamushi precludes generic immunity and allows reinfection. As a neglected disease, there is still a large gap in our knowledge of the disease, as evidenced by the sporadic epidemiologic data and other related public health information regarding scrub typhus in its endemic areas...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29099104/la-salud-durante-el-cardenismo-1934-1940
#15
Martha Eugenia Rodríguez
The present symposium, Health during the Cardenismo (1934-1940), consist of four studies: Medical sanitary aspects in Mexico by Martha Eugenia Rodríguez; Campaigns against diseases by Carlos Viesca Treviño; Hospitals during Cardenism by Guillermo Fajardo Ortiz; and Military medicine in Mexico by Antonio Moreno Guzmán. Through them is given an integral vision of the state of health and illness during the administration of General Lázaro Cárdenas del Río, the first sexennial presidential government of the twentieth century...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29078126/differential-diagnosis-of-scrub-typhus-meningitis-from-tuberculous-meningitis-using-clinical-and-laboratory-features
#16
Ashraf V Valappil, Sohanlal Thiruvoth, Jabir M Peedikayil, Praveenkumar Raghunath, Manojan Thekkedath
OBJECTIVES: The involvement of the central nervous system in the form of meningitis or meningoencephalitis is common in scrub typhus and is an important differential diagnosis of other lymphocytic meningitis like tuberculous meningitis (TBM). The aim of this study was to identify the clinical and laboratory parameters that may be helpful in differentiating scrub typhus meningitis from TBM. PATIENTS AND METHODS: We compared of the clinical and laboratory features of 57 patients admitted with scrub typhus meningitis or TBM during a 3-year period...
December 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29077073/the-biology-and-ecology-of-cat-fleas-and-advancements-in-their-pest-management-a-review
#17
REVIEW
Michael K Rust
The cat flea Ctenocephalides felis felis (Bouché) is the most important ectoparasite of domestic cats and dogs worldwide. It has been two decades since the last comprehensive review concerning the biology and ecology of C. f. felis and its management. Since then there have been major advances in our understanding of the diseases associated with C. f. felis and their implications for humans and their pets. Two rickettsial diseases, flea-borne spotted fever and murine typhus, have been identified in domestic animal populations and cat fleas...
October 27, 2017: Insects
https://www.readbyqxmd.com/read/29063197/emission-of-greenhouse-gases-and-soil-carbon-sequestration-in-a-riparian-marsh-wetland-in-central-ohio
#18
Subir K Nag, Ruiqiang Liu, Rattan Lal
Wetlands are a C sink, but they also account for a large natural source of greenhouse gases (GHG), particularly methane (CH4). Soils of wetlands play an important role in alleviating the global climate change regardless of the emission of CH4. However, there are uncertainties about the amount of C stored and emitted from wetlands because of the site specific factors. Therefore, the present study was conducted in a temperate riverine flow-through wetland, part of which was covered with emerging macrophyte Typhus latifolia in central Ohio, USA, with the objective to assess emissions of GHGs (CH4, CO2, N2O) and measure C and nitrogen (N) stocks in wetland soil in comparison to a reference upland site...
October 23, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29048284/bartonella-quintana-and-typhus-group-rickettsiae-exposure-among-homeless-persons-bogot%C3%A3-colombia
#19
Álvaro A Faccini-Martínez, Andrea C Márquez, Diana M Bravo-Estupiñan, Omar-Javier Calixto, Christian A López-Castillo, Carlos A Botero-García, Marylin Hidalgo, Claudia Cuervo
In 2015, we investigated Bartonella quintana and typhus group rickettsiae in body lice from homeless persons in Bogotá, Colombia. We found B. quintana-infected body lice and seroprevalence of this microorganism in 19% of homeless persons and typhus group rickettsiae in 56%. Public health professionals should start preemptive measures and active vector control.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29037863/outer-membrane-protein-ompb-methylation-may-mediate-bacterial-virulence
#20
REVIEW
David C H Yang, Amila H Abeykoon, Bok-Eum Choi, Wei-Mei Ching, P Boon Chock
Methylation of outer membrane proteins (OMPs) has been implicated in bacterial virulence. Lysine methylation in rickettsial OmpB is correlated with rickettsial virulence, and N- and O-methylations are also observed in virulence-relevant OMPs from several pathogenic bacteria that cause typhus, leptospirosis, tuberculosis, and anaplasmosis. We summarize recent findings on the structure of methylated OmpB, biochemical characterization, and crystal structures of OmpB methyltransferases. Native rickettsial OmpB purified from highly virulent strains contains multiple clusters of trimethyllysine, in contrast with mostly monomethyllysine, and no trimethyllysine is found in an avirulent strain...
October 13, 2017: Trends in Biochemical Sciences
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