keyword
MENU ▼
Read by QxMD icon Read
search

Typhus

keyword
https://www.readbyqxmd.com/read/29653201/kinetics-of-igm-and-igg-antibodies-after-scrub-typhus-infection-and-the-clinical-implications
#1
George M Varghese, Veera Manikandan Rajagopal, Paul Trowbridge, Divya Purushothaman, Sherry Joseph Martin
OBJECTIVES: Serology detecting IgM antibodies is the most widely used test to diagnose scrub typhus infection. However, kinetics of IgM and IgG antibodies post-infection remains elusive which could contribute to false positivity. The objective of this study is to document the nature of evolution of these antibody titers after infection. METHODS: Adult patients previously confirmed to have scrub typhus using IgM ELISA or positive PCR or both were included in this cross-sectional study...
April 10, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29590177/emergence-of-orientia-tsutsugamushi-as-an-important-cause-of-acute-encephalitis-syndrome-in-india
#2
Parul Jain, Shantanu Prakash, Piyush K Tripathi, Archana Chauhan, Shikha Gupta, Umesh Sharma, Anil K Jaiswal, Devraj Sharma, Amita Jain
BACKGROUND: Acute Encephalitis Syndrome (AES) is a major seasonal public health problem in Bihar, India. Despite efforts of the Bihar health department and the Government of India, burden and mortality of AES cases have not decreased, and definitive etiologies for the illness have yet to be identified. OBJECTIVES: The present study was undertaken to study the specific etiology of AES in Bihar. METHODS: Cerebrospinal fluid and/or serum samples from AES patients were collected and tested for various pathogens, including viruses and bacteria by ELISA and/or Real Time PCR...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29584919/genetic-diversity-of-orientia-tsutsugamushi-strains-circulating-in-northeast-india
#3
Trishna Bora, Siraj Ahmed Khan, Lobsang Jampa, Basanta Laskar
Background: Scrub typhus, caused by the intracellular bacteria Orientia tsutsugamushi is widely distributed in Southeast Asian countries with antigenically divergent strains reported across the Asia-Pacific belt. The present study was conducted to characterize the circulating strains of Orientia tsutsugamushi prevailing in two Northeastern states of India-the gateway to most Southeast Asian countries. Methods: A total of 278 (98 clinical and 180 field collected) scrub typhus positive blood samples collected from December 2014 to December 2016 were subjected for amplification of partial 56 KDa, 47 KDa and 16SrRNA genes of Orientia...
March 12, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29581051/febrile-illness-in-asia-gaps-in-epidemiology-diagnosis-management-for-informing-health-policy
#4
REVIEW
Poojan Shrestha, Tamalee Roberts, Anousin Homsana, Tin Ohn Myat, John A Crump, Yoel Lubell, Paul N Newton
BACKGROUND: There is increasing evidence on the aetiology and management of fevers in Asia, the importance of which has risen with declines in malaria incidence. AIMS: To conduct a narrative review of the epidemiology and management of fevers in South and South-East Asia and to highlight gaps in our knowledge that impair evidence-based health policy decisions. SOURCES: A narrative review of papers published since 2012 of developments in fever epidemiology, diagnosis and treatment in South and South-East Asia...
March 23, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29579046/scrub-typhus-point-of-care-testing-a-systematic-review-and-meta-analysis
#5
Kartika Saraswati, Nicholas P J Day, Mavuto Mukaka, Stuart D Blacksell
BACKGROUND: Diagnosing scrub typhus clinically is difficult, hence laboratory tests play a very important role in diagnosis. As performing sophisticated laboratory tests in resource-limited settings is not feasible, accurate point-of-care testing (POCT) for scrub typhus diagnosis would be invaluable for patient diagnosis and management. Here we summarise the existing evidence on the accuracy of scrub typhus POCTs to inform clinical practitioners in resource-limited settings of their diagnostic value...
March 26, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29567888/prevalence-of-scrub-typhus-in-pyrexia-of-unknown-origin-and-assessment-of-interleukin-8-tumor-necrosis-factor-alpha-and-interferon-gamma-levels-in-scrub-typhus-positive-patients
#6
Meher Rizvi, Asfia Sultan, Madhav Chowdhry, Mohd Azam, Fatima Khan, Indu Shukla, Haris M Khan
Background: Scrub typhus is lesser known cause of fever of unknown origin in India. Even if there have been reports documenting the prevalence of scrub typhus in different parts of India, it is still an unknown entity, and clinicians usually do not consider it as differential diagnosis. The present study was performed to document the prevalence of scrub typhus among febrile patients in western part of Uttar Pradesh and to assess the clinical profile of infected patients on the one hand and knowledge, attitude, and practices among clinicians on the other...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29553921/rickettsial-illnesses-as-important-causes-of-febrile-illness-in-chittagong-bangladesh
#7
Hugh W Kingston, Mosharraf Hossain, Stije Leopold, Tippawan Anantatat, Ampai Tanganuchitcharnchai, Ipsita Sinha, Katherine Plewes, Richard J Maude, M A Hassan Chowdhury, Sujat Paul, Rabiul Alam Mohammed Erfan Uddin, Mohammed Abu Naser Siddiqui, Abu Shahed Zahed, Abdullah Abu Sayeed, Mohammed Habibur Rahman, Anupam Barua, Mohammed Jasim Uddin, Mohammed Abdus Sattar, Arjen M Dondorp, Stuart D Blacksell, Nicholas P J Day, Aniruddha Ghose, Amir Hossain, Daniel H Paris
We conducted a yearlong prospective study of febrile patients admitted to a tertiary referral hospital in Chittagong, Bangladesh, to assess the proportion of patients with rickettsial illnesses and identify the causative pathogens, strain genotypes, and associated seasonality patterns. We diagnosed scrub typhus in 16.8% (70/416) and murine typhus in 5.8% (24/416) of patients; 2 patients had infections attributable to undifferentiated Rickettsia spp. and 2 had DNA sequence-confirmed R. felis infection. Orientia tsutsugamushi genotypes included Karp, Gilliam, Kato, and TA763-like strains, with a prominence of Karp-like strains...
April 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29548879/development-of-a-rapid-and-visual-nucleotide-detection-method-towards-an-chinese-epidemic-strain-of-orientia-tsutsugamushi-based-on-recombinase-polymerase-amplification-assay-and-lateral-flow-test
#8
Yong Qi, Qiong Yin, Yinxiu Shao, Min Cao, Suqin Li, Hongxia Chen, Wanpeng Shen, Jixian Rao, Jiameng Li, Xiaoling Li, Yu Sun, Yu Lin, Yi Deng, Wenwen Zeng, Shulong Zheng, Suyun Liu, Yuexi Li
OBJECTIVES: Orientia tsutsugamushi is an obligate intracellular pathogen that causes scrub typhus. Diagnosing scrub typhus is still a challenge and sensitive, specific, simple, and rapid diagnostic tests is in need. METHODS: Recombinase polymerase amplification (RPA) assay combined with a lateral flow (LF) test was developed and optimized targeting 56-kDa gene of a Karp-like strain of O. tsutsugamushi. Detection limits, sensitivity, specificity, and simulative clinical performance were evaluated...
March 13, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29547167/central-nervous-system-lesions-in-scrub-typhus-rediscovered-an-autopsy-report
#9
Kirti Gupta, Chirag K Ahuja, Awadh K Pandit, Manisha Biswal, M R Shivaprakash
While neurological manifestations in scrub typhus have been well described both in clinical and radiological reports in the literature, neuropathological features are rarely reported. They range from subtle "typhus nodules" to more widespread capillaritis. Familiarity with pathological features is essential for correct interpretation. We describe the clinical, imaging, and histological findings in an autopsy case of scrub typhus, which was pre-terminally superimposed by fungal meningoencephalitis...
March 2018: Neurology India
https://www.readbyqxmd.com/read/29542303/mathematical-modeling-for-scrub-typhus-and-its-implications-for-disease-control
#10
Kyung Duk Min, Sung Il Cho
BACKGROUND: The incidence rate of scrub typhus has been increasing in the Republic of Korea. Previous studies have suggested that this trend may have resulted from the effects of climate change on the transmission dynamics among vectors and hosts, but a clear explanation of the process is still lacking. In this study, we applied mathematical models to explore the potential factors that influence the epidemiology of tsutsugamushi disease. METHODS: We developed mathematical models of ordinary differential equations including human, rodent and mite groups...
March 19, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29531452/scrub-typhus-a-major-cause-of-pediatric-intensive-care-admission-and-multiple-organ-dysfunction-syndrome-a-single-center-experience-from-india
#11
Prabahs Prasun Giri, Joydeb Roy, Agnisekhar Saha
Aim of the Study: Scrub typhus has been globally recognized as an emerging infectious disease contributing significantly to pyrexia of unknown origin (PUO) and a potential cause of multiorgan dysfunction syndrome (MODS). We studied the incidence of scrub typhus as a cause of pediatric intensive care unit (PICU) admission and MODS in our hospital and its clinical and laboratory characteristics to measure the incidence of MODS caused by scrub typhus. Materials and Methods: This study was done in a pediatric teaching hospital in Kolkata, India...
February 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29522521/characterization-of-the-rhesus-macaque-macaca-mulatta-scrub-typhus-model-susceptibility-to-intradermal-challenge-with-the-human-pathogen-orientia-tsutsugamushi-karp
#12
Piyanate Sunyakumthorn, Suwit J Somponpun, Rawiwan Im-Erbsin, Tippawan Anantatat, Kemajittra Jenjaroen, Susanna J Dunachie, Eric D Lombardini, Robin L Burke, Stuart D Blacksell, James W Jones, Carl J Mason, Allen L Richards, Nicholas P J Day, Daniel H Paris
BACKGROUND: Scrub typhus is an important endemic disease in tropical Asia caused by Orientia tsutsugamushi for which no effective broadly protective vaccine is available. The successful evaluation of vaccine candidates requires well-characterized animal models and a better understanding of the immune response against O. tsutsugamushi. While many animal species have been used to study host immunity and vaccine responses in scrub typhus, only limited data exists in non-human primate (NHP) models...
March 9, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29509943/evaluation-of-haematological-and-volume-conductivity-and-scatter-parameters-of-leucocytes-for-aetiological-diagnosis-of-undifferentiated-fevers
#13
Vikas Shrivastava, Sohaib Ahmad, Garima Mittal, Vibha Gupta, Nadia Shirazi, Varun Kalra
Background: In this follow-up study, we aimed to establish the cut-off values of the volume, conductivity and scatter (VCS) parameters of leucocytes that significantly differ in dengue fever, malaria, scrub typhus and enteric fever, as described in our pilot study. Methods: A prospective observational case-control study was undertaken on patients with an established diagnosis of acute malaria (n=476), dengue fever (n=927), scrub typhus (n=425), bacterial sepsis (n=1598) or enteric fever (n=885) and the haematological and VCS data obtained by the Coulter LH 750 analyser were compared with controls...
March 2, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29494599/autofluorescence-microscopy-for-paired-matched-morphological-and-molecular-identification-of-individual-chigger-mites-acari-trombiculidae-the-vectors-of-scrub-typhus
#14
Rawadee Kumlert, Kittipong Chaisiri, Tippawan Anantatat, Alexandr A Stekolnikov, Serge Morand, Anchana Prasartvit, Benjamin L Makepeace, Sungsit Sungvornyothin, Daniel H Paris
BACKGROUND: Conventional gold standard characterization of chigger mites involves chemical preparation procedures (i.e. specimen clearing) for visualization of morphological features, which however contributes to destruction of the arthropod host DNA and any endosymbiont or pathogen DNA harbored within the specimen. METHODOLOGY/PRINCIPAL FINDINGS: In this study, a novel work flow based on autofluorescence microscopy was developed to enable identification of trombiculid mites to the species level on the basis of morphological traits without any special preparation, while preserving the mite DNA for subsequent genotyping...
2018: PloS One
https://www.readbyqxmd.com/read/29488593/-some-information-regarding-the-historical-development-of-typhoid-fever-in-chile
#15
Enrique Laval
During the historical development of typhoid fever in Chile, its confusion with other infectious diseases is particularly noteworthy, especially with murine typhus, a problem that was mainly resolved during the 1918 epidemic. The importance of chloramphenicol treatment is also highlighted, which meant an enormous improvement in typhoid/paratyphoid fevers, in combination with public health and health education actions that allowed to almost eliminate these infectious diseases in our country.
October 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29486240/under-diagnosis-of-rickettsial-disease-in-clinical-practice-a-systematic-review
#16
REVIEW
Louise E van Eekeren, Sophia G de Vries, Jiri F P Wagenaar, René Spijker, Martin P Grobusch, Abraham Goorhuis
BACKGROUND: Rickettsial diseases present as acute febrile illnesses, sometimes with inoculation eschars. METHODS: We performed a systematic review of studies published between 1997 and 2017 to assess the underestimation of non-eschar rickettsial disease (NERD) relative to eschar rickettsial disease (ERD), as a cause of acute fever in patients with rickettsial diseases that commonly present with eschar(s): scrub typhus (ST), Mediterranean spotted fever (MSF), and African tick-bite fever...
March 1, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29465481/murine-typhus-in-south-texas-children-an-18-year-review
#17
Ashley Howard, Jaime Fergie
BACKGROUND: Murine typhus is a zoonotic infection caused by Rickettsia typhi that remains endemic in South Texas. In 2003, only 9 Texas counties reported murine typhus compared with 41 counties in 2013. METHODS: A retrospective study of children discharged with a confirmed diagnosis of murine typhus from Driscoll Children's Hospital between January 1998-September 2016. RESULTS: 213 children (113 female) 3 months through 19 years of age (mean, 11...
February 19, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29462266/effects-of-rifampin-and-doxycycline-treatments-in-patients-with-uncomplicated-scrub-typhus-an-open-label-randomized-controlled-trial
#18
Yun Sung Kim, Dong-Min Kim, Na-Ra Yoon, Mi-Sun Jang, Choon-Mee Kim
Background: Doxycycline is currently the most frequently used treatment in patients with scrub typhus, but doxycycline-resistant strains have been found, necessitating the development of a new treatment. Rifampin is known to be effective even for such strains. Thus, this study aimed to compare the effects of rifampin and doxycycline treatment in patients with scrub typhus in areas in which resistance to doxycycline has not been reported. Methods: Patients admitted to Chosun University Hospital and regional network hospitals between 2007 and 2009 with a body temperature of 37...
February 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29460869/scrub-typhus-in-mizoram-india
#19
H Lalrinkima, R Lalremruata, C Lalchhandama, Lalthansanga Khiangte, Freddy H Siamthara, C Lalnunpuia, S K Borthakur, Gautam Patra
No abstract text is available yet for this article.
October 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29460860/aetiology-of-acute-encephalitis-syndrome-in-uttar-pradesh-india-from-2014-to-2016
#20
Parul Jain, Shantanu Prakash, Danish N Khan, Ravindra Kumar Garg, Rashmi Kumar, Amit Bhagat, V Ramakrishna, Amita Jain
Background & objectives: It is imperative to know the aetiology of acute encephalitis syndrome (AES) for patient management and policy making. The present study was carried out to determine the prevalence of common aetiological agents of AES in Uttar Pradesh (UP) state of India. Methods: Serum and/or CSF samples were collected from AES patients admitted at Gandhi Memorial and Associated Hospital, King George's Medical University, Lucknow, a tertiary care centre, UP during 2014-16...
October 2017: Journal of Vector Borne Diseases
keyword
keyword
18381
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"