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https://www.readbyqxmd.com/read/28103630/orientia-tsutsugamushi-ank9-is-a-multifunctional-effector-that-utilizes-a-novel-grip-like-golgi-localization-domain-for-golgi-to-endoplasmic-reticulum-trafficking-and-interacts-with-host-copb2
#1
Andrea R Beyer, Kyle G Rodino, Lauren VieBrock, Ryan S Green, Brittney K Tegels, Lee D Oliver, Richard T Marconi, Jason A Carlyon
Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that afflicts one million people annually. This obligate intracellular bacterium boasts one of the largest microbial arsenals of ankyrin repeat-containing protein (Ank) effectors, most of which target the endoplasmic reticulum (ER) by undefined mechanisms. Ank9 is the only one proven to function during infection. Here, we demonstrate that Ank9 bears a motif that mimics the GRIP domain of eukaryotic golgins and is necessary and sufficient for its Golgi localization...
January 19, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28088326/acute-kidney-injury-due-to-tropical-infectious-diseases-and-animal-venoms-a-tale-of-2-continents
#2
REVIEW
Emmanuel A Burdmann, Vivekanand Jha
South and Southeast Asia and Latin American together comprise 46 countries and are home to approximately 40% of the world population. The sociopolitical and economic heterogeneity, tropical climate, and malady transitions characteristic of the region strongly influence disease behavior and health care delivery. Acute kidney injury epidemiology mirrors these inequalities. In addition to hospital-acquired acute kidney injury in tertiary care centers, these countries face a large preventable burden of community-acquired acute kidney injury secondary to tropical infectious diseases or animal venoms, affecting previously healthy young individuals...
January 11, 2017: Kidney International
https://www.readbyqxmd.com/read/28086810/genotypic-characterization-of-orientia-tsutsugamushi-from-patients-in-two-geographical-locations-in-sri-lanka
#3
Ranjan Premaratna, Lucas S Blanton, Dilhar N Samaraweera, G Nalika N de Silva, Nilmini T G A Chandrasena, David H Walker, H J de Silva
BACKGROUND: To date more than 20 antigenically distinct strains of Orientia tsutsugamushi (OT) reported within the tsutsugamushi triangle that cause an undifferentiated acute febrile illness in humans. Genotypic characterization of OT in different geographic regions or within the same country, is important in order to establish effective diagnostics, clinical management and to develop effective vaccines. Genetic and antigenic characterization of OT causing human disease in OT-endemic regions is not known for Sri Lanka...
January 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28056840/rapid-increase-of-scrub-typhus-incidence-in-guangzhou-southern-china-2006-2014
#4
Ye Sun, Yue-Hong Wei, Yang Yang, Yu Ma, Sake J de Vlas, Hong-Wu Yao, Yong Huang, Mai-Juan Ma, Kun Liu, Xiao-Ning Li, Xin-Lou Li, Wen-Hui Zhang, Li-Qun Fang, Zhi-Cong Yang, Wu-Chun Cao
BACKGROUND: In the last decade, scrub typhus (ST) has been emerging or re-emerging in some areas of Asia, including Guangzhou, one of the most affected endemic areas of ST in China. METHODS: Based on the data on all cases reported in Guangzhou from 2006 to 2014, we characterized the epidemiological features, and identified environmental determinants for the spatial distribution of ST using a panel negative binomial model. RESULTS: A total of 4821 scrub typhus cases were reported in Guangzhou during 2006-2014...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28056811/evaluation-of-a-broad-ranging-and-convenient-enzyme-linked-immunosorbent-assay-using-the-lysate-of-infected-cells-with-five-serotypes-of-orientia-tsutsugamushi-a-causative-agent-of-scrub-typhus
#5
Motohiko Ogawa, Masaaki Satoh, Masayuki Saijo, Shuji Ando
BACKGROUND: Scrub typhus is a mite-borne rickettsiosis caused by infection of Orientia tsutsugamushi, which is endemic to several Asia-Pacific Rim countries, including Japan. Although micro-indirect immunofluorescent assay (micro-IFA) is the standard method for the serological diagnosis of scrub typhus, enzyme-linked immunosorbent assay (ELISA) is considered to be more objective, by providing digitized results as opposed to being subject to the judgment of the evaluator as in micro-IFA...
January 5, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28055333/differences-in-clinical-and-laboratory-features-for-different-genotypes-of-orientia-tsutsugamushi-in-guangzhou-southern-china
#6
Yuehong Wei, Yu Ma, Lei Luo, Xinwei Wu, Yong Huang, Xiaoning Li, Zhicong Yang
PURPOSE: To describe the genotypes distribution of Orientia tsutsugamushi, in Guangzhou, and explore differences in clinical and laboratory features among genotypes. METHOD: We collected blood or eschar samples of all scrub typhus cases reported in 2013 from 10 district hospitals positive for PCR. We further tested the PCR-positive samples for DNA sequencing and phylogenetic analysis. We collected the demographic, clinical, and laboratory data by questionnaire and medical records...
January 5, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28050364/serological-diagnosis-of-acute-scrub-typhus-in-southern-india-evaluation-of-inbios-scrub-typhus-detect-igm-rapid-test-and-comparison-with-other-serological-tests
#7
Velmurugan Anitharaj, Selvaraj Stephen, Jothimani Pradeep, Sungman Park, Seung-Han Kim, Young Jin Kim, Eun-Ye Kim, Yoon-Won Kim
INTRODUCTION: Scrub Typhus (ST) is being reported from different parts of India in the recent past. However, the diagnosis and confirmation of ST cases require specific serological and molecular diagnostic tests. Both rapid and conventional ELISA tests need to be properly evaluated. AIM: Evaluation of a new ST IgM Immunochromatography (ICT) test kit (InBios Scrub Typhus Detect IgM Rapid Test) and compare it with another rapid kit, conventional ELISA kit and Weil-Felix (WF) test...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28044222/scrub-typhus-radiological-and-clinical-findings-in-abdominopelvic-involvement
#8
Kun Yung Kim, Ji Soo Song, Eun Hae Park, Gong Yong Jin
PURPOSE: To describe the clinical and radiological findings of abdominopelvic involvement in scrub typhus. MATERIALS AND METHODS: Abdominopelvic computed tomography (CT) of 78 patients with scrub typhus were evaluated by two readers. The presence of gallbladder wall thickening, arterial inhomogeneous enhancement of the liver, periportal edema, splenic infarction, hepatomegaly, splenomegaly, ascites, pleural effusion, and sites of lymphadenopathy were evaluated. Patients were divided into four clinical subgroups according to laboratory findings...
January 2, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28036394/first-identification-and-description-of-rickettsioses-and-q-fever-as-causes-of-acute-febrile-illness-in-nicaragua
#9
Megan E Reller, Ijeuru Chikeka, Jeremy J Miles, J Stephen Dumler, Christopher W Woods, Orlando Mayorga, Armando J Matute
BACKGROUND: Rickettsial infections and Q fever present similarly to other acute febrile illnesses, but are infrequently diagnosed because of limited diagnostic tools. Despite sporadic reports, rickettsial infections and Q fever have not been prospectively studied in Central America. METHODOLOGY/PRINCIPAL FINDINGS: We enrolled consecutive patients presenting with undifferentiated fever in western Nicaragua and collected epidemiologic and clinical data and acute and convalescent sera...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28031350/a-molecular-survey-for-francisella-tularensis-and-rickettsia-spp-in-haemaphysalis-leporispalustris-acari-ixodidae-in-northern-california
#10
Tara Roth, Robert S Lane, Janet Foley
Francisella tularensis and Rickettsia spp. have been cultured from Haemaphysalis leporispalustris Packard, but their prevalence in this tick has not been determined using modern molecular methods. We collected H. leporispalustris by flagging vegetation and leaf litter and from lagomorphs (Lepus californicus Gray and Sylvilagus bachmani (Waterhouse)) in northern California. Francisella tularensis DNA was not detected in any of 1,030 ticks tested by polymerase chain reaction (PCR), whereas 0.4% of larvae tested in pools, 0 of 117 individual nymphs, and 2...
December 28, 2016: Journal of Medical Entomology
https://www.readbyqxmd.com/read/27983969/clinical-and-laboratory-characteristics-epidemiology-and-outcomes-of-murine-typhus-a-systematic-review
#11
REVIEW
Constantinos Tsioutis, Maria Zafeiri, Asimakis Avramopoulos, Efthymia Prousali, Michael Miligkos, Spyridon A Karageorgos
Murine or endemic typhus, a febrile disease caused by Rickettsia typhi, is often misdiagnosed due to its non-specific presentation. We sought to evaluate all available evidence in the literature regarding the clinical and laboratory manifestations, epidemiological characteristics, and outcomes of murine typhus. Pubmed was searched for all articles providing available data. In an effort to incorporate contemporary data, only studies from 1980 were included. Thirty-three case series including 2074 patients were included in final analysis...
February 2017: Acta Tropica
https://www.readbyqxmd.com/read/27981627/characteristics-of-pediatric-scrub-typhus-eschar-in-south-indian-children
#12
Thirunavukkarasu Arun Babu, Vijayasankar Vijayadevagaran, Shanthi Ananthakrishnan
BACKGROUND: Knowledge of anatomic location of eschar is useful in diagnosing scrub typhus early in children and to initiate appropriate treatment. METHODS: All children younger than 12 years of age admitted with confirmed diagnosis of scrub typhus over a 17-month period were included and the presence of eschar and other characteristics were recorded and analyzed. RESULTS: Of 107 confirmed patients with scrub typhus, 37 (34.6%) presented with eschar...
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27977689/tick-borne-diseases-in-turkey-a-review-based-on-one-health-perspective
#13
REVIEW
Abdullah Inci, Alparslan Yildirim, Onder Duzlu, Mehmet Doganay, Serap Aksoy
The importance of tick-borne diseases is increasing all over the world, including Turkey. Global warming, environmental and ecological changes and the existence of suitable habitats increase the impact of ticks and result in frequent emergence or re-emergence of tick-borne diseases (TBDs) with zoonotic characteristics. In Turkey, almost 19 TBDs have been reported in animals and men, involving four protozoa (babesiosis, theileriosis, cytauxzoonosis, hepatozoonosis), one filarial nematode (acanthocheilonemasis), ten bacterial agents (anaplasmosis, ehrlichiosis, aegyptianellosis, tick-borne typhus, Candidatus Rickettsia vini, Lyme borreliosis, tick-borne relapsing fever [TBRF], tularaemia, bartonellosis, and hemoplasmosis), and four viral infections (tick-borne encephalitis [TBE], Crimean-Congo Haemorrhagic Fever [CCHF], louping-ill [LI], and lumpy skin disease [LSD])...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27966835/the-epidemiology-and-characteristics-of-q-fever-and-co-infections-with-scrub-typhus-murine-typhus-or-leptospirosis-in-taiwan-a-nationwide-database-study
#14
C-H Lai, W Sun, C-H Lee, J-N Lin, M-H Liao, S-S Liu, T-Y Chang, K-F Tsai, Y-C Chang, H-H Lin, Y-H Chen
Q fever (QF) is a worldwide zoonosis associated with outbreaks. Only a few nationwide studies regarding the surveillance and epidemiology of human QF have been reported. Although QF is endemic in Taiwan, a nationwide database investigation of the epidemiology and characteristics of QF and its associations with scrub typhus (ST), murine typhus (MT) and leptospirosis (LS) has never been reported. We analysed nationwide databases of suspected QF, ST, MT and LS cases from October 2007 to December 2014 obtained from the Centers for Disease Control, Taiwan...
December 14, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27942194/acute-undifferentiated-febrile-illness-in-patients-presenting-to-a-tertiary-care-hospital-in-south-india-clinical-spectrum-and-outcome
#15
Kundavaram Paul Prabhakar Abhilash, Jonathan Arul Jeevan, Shubhanker Mitra, Nirvin Paul, Thimiri Palani Murugan, Ajay Rangaraj, Sandeep David, Samuel George Hansdak, John Antony Jude Prakash, Asha Mary Abraham, Prakash Ramasami, Sowmya Sathyendra, Thambu David Sudarsanam, George M Varghese
BACKGROUND: Acute undifferentiated febrile illness (AUFI) may have similar clinical presentation, and the etiology is varied and region specific. MATERIALS AND METHODS: This prospective observational study was conducted in a tertiary hospital in South India. All adult patients presenting with AUFI of 3-14 days duration were evaluated for etiology, and the differences in presentation and outcome were analyzed. RESULTS: The study cohort included 1258 patients...
October 2016: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/27928094/seroconversion-to-causes-of-febrile-illness-in-mongolian-peacekeepers-deployed-to-south-sudan
#16
Altangerel Enkhtsetseg, Rendoo Davadoorj, Stefan Fernandez, Duangrat Mongkolsirichaikul, Damdin Altantuul, Erdene Elbegdorj, Lkhagvasuren Ganchimeg, Samuel L Yingst
Immediately before deployment (Fall 2012) and after deployment (Spring 2013) in support of United Nations peacekeeping operations, Mongolian Armed Forces medical personnel obtained serum samples from the first contingent of Mongolian peacekeepers deploying to South Sudan to monitor serologic evidence of exposure to diseases that cause acute febrile illness. A total of 632 paired samples were tested for IgG antibody for the following (number of seroconversions in parentheses): Rickettsia (spotted fever and typhus groups) (25), West Nile fever virus (WNV) (23), Coxiella burnetii (causative agent of Q fever) (12), dengue virus (8), leptospirosis (6), chikungunya virus (0), Congo-Crimean hemorrhagic fever virus (0), Japanese encephalitis virus (0), and Rift Valley fever virus (0)...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27928073/evolution-of-eschar-in-scrub-typhus
#17
Jin Park, Soo-Han Woo, Chang-Seop Lee
No abstract text is available yet for this article.
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27924792/a-cost-effective-approach-to-the-diagnosis-and-management-of-acute-infectious-encephalitis
#18
Usha Kant Misra, Vinita Elizabeth Mani, Jayantee Kalita
SETTING: A tertiary care teaching hospital in India. OBJECTIVE: To report a syndromic approach to acute encephalitis syndrome (AES) and propose a cost-effective model. STUDY DESIGN: AES patients were categorized by the presence or absence of myalgia/rash into systemic and neurological AES. The patients with systemic AES were investigated for dengue, scrub typhus, leptospira, chikungunya, and malaria, and those with neurological AES were investigated for herpes and Japanese encephalitis (JE)...
2017: European Neurology
https://www.readbyqxmd.com/read/27908651/eschar-a-stepping-stone-to-scrub-typhus
#19
Shu-Chao Weng, Hung-Chang Lee, Jeng-Jung Chen, Yu-Jyun Cheng, Hsin Chi, Chien-Yu Lin
No abstract text is available yet for this article.
November 28, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27905346/bevacizumab-in-choroidal-neovascularization-secondary-to-indian-tick-typhus-a-rare-case-report
#20
Raghavendra Ijeri, Gautam Beladiya, Sharad Bhomaj
Tick typhus causes hemorrhagic lesions over the skin. Retina also shows hemorrhages and exudates. Many cases have been reported in western literature about this condition. To our best of knowledge, this is the first case report of tick typhus in India which was also associated with inflammatory choroidal neovascularization.
October 2016: Indian Journal of Ophthalmology
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