keyword
MENU ▼
Read by QxMD icon Read
search

MAIT cell

keyword
https://www.readbyqxmd.com/read/29779871/non-canonical-phototransduction-mediates-synchronization-of-the-drosophila-melanogaster-circadian-clock-and-retinal-light-responses
#1
Maite Ogueta, Roger C Hardie, Ralf Stanewsky
The daily light-dark cycles represent a key signal for synchronizing circadian clocks. Both insects and mammals possess dedicated "circadian" photoreceptors but also utilize the visual system for clock resetting. In Drosophila, circadian clock resetting is achieved by the blue-light photoreceptor cryptochrome (CRY), which is expressed within subsets of the brain clock neurons. In addition, rhodopsin-expressing photoreceptor cells contribute to light synchronization. Light resets the molecular clock by CRY-dependent degradation of the clock protein Timeless (TIM), although in specific subsets of key circadian pacemaker neurons, including the small ventral lateral neurons (s-LNvs), TIM and Period (PER) oscillations can be synchronized by light independent of CRY and canonical visual Rhodopsin phototransduction...
April 30, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29773261/perioperative-transfusion-management-in-gastric-cancer-surgery-analysis-of-the-spanish-subset-of-the-eurecca-oesophago-gastric-cancer-registry
#2
Javier Osorio, Carlos Jericó, Coro Miranda, Elisenda Garsot, Alexis Luna, Mónica Miró, Maite Santamaría, Eva Artigau, Joaquín Rodríguez-Santiago, Sandra Castro, Josep Feliu, Aurora Aldeano, Carles Olona, Dulce Momblan, David Ruiz, Gonzalo Galofré, Inmaculada Pros, Xabier García-Albéniz, Miguel Lozano, Manuel Pera
INTRODUCTION: This study evaluated allogenic packed red blood cell (aPRBC) transfusion rates in patients undergoing resection for gastric cancer and the implementation of blood-saving protocols (BSP). METHODS: Retrospective study of all gastric cancer patients operated on with curative intent in Catalonia and Navarra (2011-2013) and included in the Spanish subset of the EURECCA Oesophago-Gastric Cancer Registry. Hospitals with BSP were defined as those with a preoperative haemoglobin (Hb) optimisation circuit associated with restrictive transfusion strategies...
May 14, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29766731/-current-and-prospective-biologics-and-small-molecules-in-the-treatment-of-inflammatory-bowel-diseases
#3
Milan Buc
Crohns disease (CD) and ulcerative colitis (UC) belong to chronic inflammatory bowel diseases, which are induced by autoimmune processes. While CD is characterized by over-activity of Th1, ILC1, and MAIT cells, UC is mediated by exaggerated activities of Th2 and ILC2 cells and cytokines they produce. Knowledge of the pathogenesis enabled a rational therapy based mostly on biologics and small molecules. TNF is the principal proinflammatory cytokine in both diseases. Anti-TNF monoclonal antibodies, mostly infliximab or adalimumab were therefore introduced to their treatment...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29754112/mr1-antigen-presentation-to-mait-cells-new-ligands-diverse-pathways
#4
REVIEW
Hamish Eg McWilliam, Jose A Villadangos
The major histocompatibility complex class I-related molecule MR1 is the only antigen (Ag) presenting molecule that captures and displays vitamin B-derived metabolites that are unique to a wide array of microbes. Presentation of these metabolite Ag at the cell surface activates mucosal-associated invariant T (MAIT) cells, a highly abundant innate-like T cell population, and represents a recently-described mechanism used by the mammalian immune system to sense pathogenic or commensal microbes. Our understanding of the cell biology of how MR1 accomplishes this unique task is still evolving, but recent advances are allowing a general picture to emerge...
May 10, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29749611/proteomic-definition-of-human-mucosal-associated-invariant-t-cells-determines-their-unique-molecular-effector-phenotype
#5
Björn Bulitta, Werner Zuschratter, Isabel Bernal, Dunja Bruder, Frank Klawonn, Martin von Bergen, Henrikus Stephanus Paulus Garritsen, Lothar Jänsch
Mucosal-associated invariant T cells (MAIT) constitute the most abundant anti-bacterial CD8+ T cell population in humans. MR1/TCR-activated MAIT cells were reported to organize cytotoxic and innate-like responses but knowledge about their molecular effector phenotype is still fragmentary. Here, we have examined the functional inventory of human MAIT cells (CD3+Vα7.2+CD161+) in comparison with those from conventional non-MAIT CD8+ T cells (cCD8+ ) and NK cells. Quantitative mass spectrometry characterized 5500 proteins of primary MAIT cells and identified 160 and 135 proteins that discriminate them from cCD8+ T cells and NK cells donor-independently...
May 11, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29743663/drp-1-mediated-apoptosis-induces-muscle-degeneration-in-dystrophin-mutants
#6
Charlotte Scholtes, Stéphanie Bellemin, Edwige Martin, Maïté Carre-Pierrat, Bertrand Mollereau, Kathrin Gieseler, Ludivine Walter
Mitochondria are double-membrane subcellular organelles with highly conserved metabolic functions including ATP production. Mitochondria shapes change continually through the combined actions of fission and fusion events rendering mitochondrial network very dynamic. Mitochondria are largely implicated in pathologies and mitochondrial dynamics is often disrupted upon muscle degeneration in various models. Currently, the exact roles of mitochondria in the molecular mechanisms that lead to muscle degeneration remain poorly understood...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29743612/modulation-of-bacterial-metabolism-by-the-microenvironment-controls-mait-cell-stimulation
#7
Mathias Schmaler, Alessia Colone, Julian Spagnuolo, Michael Zimmermann, Marco Lepore, Artem Kalinichenko, Sumedha Bhatia, Fabien Cottier, Tobias Rutishauser, Norman Pavelka, Adrian Egli, Elisa Azzali, Marco Pieroni, Gabriele Costantino, Petr Hruz, Uwe Sauer, Lucia Mori, Gennaro De Libero
Mucosal-associated invariant T (MAIT) cells are abundant innate-like T lymphocytes in mucosal tissues and recognize a variety of riboflavin-related metabolites produced by the microbial flora. Relevant issues are whether MAIT cells are heterogeneous in the colon, and whether the local environment influences microbial metabolism thereby shaping MAIT cell phenotypes and responses. We found discrete MAIT cell populations in human colon, characterized by the diverse expression of transcription factors, cytokines and surface markers, indicative of activated and precisely controlled lymphocyte populations...
May 9, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29740432/unique-and-common-features-of-innate-like-human-v%C3%AE-2-%C3%AE-%C3%AE-t-cells-and-mucosal-associated-invariant-t-cells
#8
Nicholas M Provine, Benedikt Binder, Michael E B FitzPatrick, Anita Schuch, Lucy C Garner, Kate D Williamson, Bonnie van Wilgenburg, Robert Thimme, Paul Klenerman, Maike Hofmann
Mucosal-associated invariant T (MAIT) cells are innate-like T cells abundant in humans that can be activated in a TCR-independent manner by inflammatory and antiviral cytokines. In humans, the capacity for TCR-independent activation is functionally linked to a transcriptional program that can be identified by the expression of the C-type lectin receptor, CD161. In addition to MAIT cells, it has been demonstrated that a subset of γδT cells expresses CD161 and can be activated by TCR-independent cytokine stimulation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29731053/severely-impaired-control-of-bacterial-infections-in-a-patient-with-cystic-fibrosis-defective-in-mucosal-associated-invariant-t-cells
#9
Terezia Pincikova, Dominic Paquin-Proulx, Markus Moll, Malin Flodström-Tullberg, Lena Hjelte, Johan K Sandberg
Here we report a unique case of a patient with cystic fibrosis characterized by severely impaired control of bacterial respiratory infections. This patient's susceptibility to such infections was much worse than expected from a cystic fibrosis clinical perspective, and he died at age 22 years despite extensive efforts and massive use of antibiotics. We found that this severe condition was associated with a near-complete deficiency in circulating mucosal-associated invariant T (MAIT) cells as measured at several time points...
May 2018: Chest
https://www.readbyqxmd.com/read/29722299/the-adjustment-of-%C3%AE-aminobutyric-acid-a-tonic-subunits-in-huntington-s-disease-from-transcription-to-translation-to-synaptic-levels-into-the-neostriatum
#10
REVIEW
Abraham Rosas-Arellano, Argel Estrada-Mondragón, Carola A Mantellero, Carlos Tejeda-Guzmán, Maite A Castro
γ-Aminobutyric acid (GABA), plays a key role in all stages of life, also is considered the main inhibitory neurotransmitter. GABA activates two kind of membrane receptors known as GABAA and GABAB , the first one is responsible to render tonic inhibition by pentameric receptors containing α4-6, β3, δ, or ρ1-3 subunits, they are located at perisynaptic and/or in extrasynaptic regions. The biophysical properties of GABAA tonic inhibition have been related with cellular protection against excitotoxic injury and cell death in presence of excessive excitation...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29684377/biphasic-modulation-of-camp-levels-by-the-contraceptive-nomegestrol-acetate-impact-on-p-glycoprotein-expression-and-activity-in-hepatic-cells
#11
Guillermo Nicolás Tocchetti, Camila Juliana Domínguez, Felipe Zecchinati, Maite Rocío Arana, María Laura Ruiz, Silvina Stella Maris Villanueva, Johanna Weiss, Aldo Domingo Mottino, Juan Pablo Rigalli
ABC transporters are key players in drug excretion with alterations in their expression and activity by therapeutic agents potentially leading to drug-drug interactions. The interaction potential of nomegestrol acetate (NMGA), a synthetic progestogen increasingly used as oral contraceptive, had never been explored. In this work we evaluated (1) the effect of NMGA on ABC transporters in the human hepatic cell line HepG2 and (2) the underlying molecular mechanism. NMGA (5, 50 and 500 nM) increased P-glycoprotein (P-gp) expression at both protein and mRNA levels and reduced intracellular calcein accumulation, indicating an increase also in transporter activity...
April 20, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29675004/the-fast-growing-brucella-suis-biovar-5-depends-on-phosphoenolpyruvate-carboxykinase-and-pyruvate-phosphate-dikinase-but-not-on-fbp-and-glpx-fructose-1-6-bisphosphatases-or-isocitrate-lyase-for-full-virulence-in-laboratory-models
#12
Amaia Zúñiga-Ripa, Thibault Barbier, Leticia Lázaro-Antón, María J de Miguel, Raquel Conde-Álvarez, Pilar M Muñoz, Jean J Letesson, Maite Iriarte, Ignacio Moriyón
Bacteria of the genus Brucella infect a range of vertebrates causing a worldwide extended zoonosis. The best-characterized brucellae infect domestic livestock, behaving as stealthy facultative intracellular parasites. This stealthiness depends on envelope molecules with reduced pathogen-associated molecular patterns, as revealed by the low lethality and ability to persist in mice of these bacteria. Infected cells are often engorged with brucellae without signs of distress, suggesting that stealthiness could also reflect an adaptation of the parasite metabolism to use local nutrients without harming the cell...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29668066/mait-cell-mediated-cytotoxicity-roles-in-host-defense-and-therapeutic-potentials-in-infectious-diseases-and-cancer
#13
REVIEW
Patrick T Rudak, Joshua Choi, S M Mansour Haeryfar
Mucosa-associated invariant T (MAIT) cells are unconventional, innate-like T lymphocytes that sense the presence of MHC-related protein 1 (MR1)-restricted ligands and select inflammatory cues. Consequently, they release potent immunomodulatory mediators, including IFN-γ, TNF-α, and/or IL-17. MAIT cells can also be viewed as killer cells. They display several NK cell-associated receptors, carry granules containing cytotoxic effector molecules, and swiftly upregulate perforin and granzymes upon activation. Accordingly, MAIT cells are capable of lysing MR1-expressing cells infected with a variety of pathogenic bacteria in in vitro settings and may also mount cytotoxic responses during microbial infections in vivo...
April 18, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29656544/an-overview-on-the-identification-of-mait-cell-antigens
#14
Lars Kjer-Nielsen, Alexandra J Corbett, Zhenjun Chen, Ligong Liu, Jeffrey Y W Mak, Dale I Godfrey, Jamie Rossjohn, David P Fairlie, James McCluskey, Sidonia B G Eckle
Mucosal Associated Invariant T (MAIT) cells are restricted by the monomorphic MHC class I-like molecule, MHC-related protein-1 (MR1). Until 2012, the origin of the MAIT cell antigens (Ags) was unknown, although it was established that MAIT cells could be activated by a broad range of bacteria and yeasts, possibly suggesting a conserved Ag. Using a combination of protein chemistry, mass spectrometry, cellular biology, structural biology and chemistry, we discovered MAIT cell ligands derived from folic acid (vitamin B9) and from an intermediate in the microbial biosynthesis of riboflavin (vitamin B2)...
April 14, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29629900/recipient-mucosal-associated-invariant-t-cells-control-gvhd-within-the-colon
#15
Antiopi Varelias, Mark D Bunting, Kate L Ormerod, Motoko Koyama, Stuart D Olver, Jasmin Straube, Rachel D Kuns, Renee J Robb, Andrea S Henden, Leanne Cooper, Nancy Lachner, Kate H Gartlan, Olivier Lantz, Lars Kjer-Nielsen, Jeffrey Yw Mak, David P Fairlie, Andrew D Clouston, James McCluskey, Jamie Rossjohn, Steven W Lane, Philip Hugenholtz, Geoffrey R Hill
Mucosal-associated invariant T (MAIT) cells are a unique innate-like T cell subset that responds to a wide array of bacteria and yeast through recognition of riboflavin metabolites presented by the MHC class I-like molecule MR1. Here, we demonstrate using MR1 tetramers that recipient MAIT cells are present in small but definable numbers in graft-versus-host disease (GVHD) target organs and protect from acute GVHD in the colon following bone marrow transplantation (BMT). Consistent with their preferential juxtaposition to microbial signals in the colon, recipient MAIT cells generate large amounts of IL-17A, promote gastrointestinal tract integrity, and limit the donor alloantigen presentation that in turn drives donor Th1 and Th17 expansion specifically in the colon after BMT...
April 9, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29618662/human-mait-cells-exit-peripheral-tissues-and-recirculate-via-lymph-in-steady-state-conditions
#16
Valentin Voillet, Marcus Buggert, Chloe K Slichter, Julia D Berkson, Florian Mair, Mary M Addison, Yoav Dori, Gregory Nadolski, Maxim G Itkin, Raphael Gottardo, Michael R Betts, Martin Prlic
Mucosal-associated invariant T cells (MAIT cells) recognize bacterial metabolites as antigen and are found in blood and tissues, where they are poised to contribute to barrier immunity. Recent data demonstrate that MAIT cells located in mucosal barrier tissues are functionally distinct from their blood counterparts, but the relationship and circulation of MAIT cells between blood and different tissue compartments remains poorly understood. Previous studies raised the possibility that MAIT cells do not leave tissue and may either be retained or undergo apoptosis...
April 5, 2018: JCI Insight
https://www.readbyqxmd.com/read/29616020/hyper-expression-of-pd-1-is-associated-with-the-levels-of-exhausted-and-dysfunctional-phenotypes-of-circulating-cd161-tcr-iv%C3%AE-7-2-mucosal-associated-invariant-t-cells-in-chronic-hepatitis-b-virus-infection
#17
Yean K Yong, Alireza Saeidi, Hong Y Tan, Mohamed Rosmawati, Philip F Enström, Rami Al Batran, V Vasuki, Indranil Chattopadhyay, Amudhan Murugesan, Ramachandran Vignesh, Adeeba Kamarulzaman, Jayakumar Rajarajeswaran, Abdul W Ansari, Jamuna Vadivelu, James E Ussher, Vijayakumar Velu, Marie Larsson, Esaki M Shankar
Mucosal-associated invariant T (MAIT) cells, defined as CD161++ TCR iVα7.2+ T cells, play an important role in the innate defense against bacterial infections, and their functionality is impaired in chronic viral infections. Here, we investigated the frequency and functional role of MAIT cells in chronic hepatitis B virus (HBV) infection. The peripheral CD3+ CD161++ TCR iVα7.2+ MAIT cells in chronic HBV-infected patients and healthy controls were phenotypically characterized based on CD57, PD-1, TIM-3, and CTLA-4, as well as HLA-DR and CD38 expression...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29597306/biocompatibility-of-gd-loaded-chitosan-hyaluronic-acid-nanogels-as-contrast-agents-for-magnetic-resonance-cancer-imaging
#18
Cecilia Virginia Gheran, Guillaume Rigaux, Maité Callewaert, Alexandre Berquand, Michael Molinari, Françoise Chuburu, Sorina Nicoleta Voicu, Anca Dinischiotu
Although the research on nanogels incorporating Gd chelates for theranostic applications has grown exponentially in recent years, knowledge about their biocompatibility is limited. We compared the biocompatibility of Gd-loaded hyaluronic acid-chitosan-based nanogels (GdCA⊂CS-TPP/HA) with two chitosan concentrations (2.5 and 1.5 mg·mL-1 respectively) using SVEC4-10 murine lymph node endothelial cells. The sulforhodamine B method and released lactate dehydrogenase (LDH) activity were used as cell viability tests...
March 28, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29582588/altered-lactate-metabolism-in-huntington-s-disease-is-dependent-on-glut3-expression
#19
Macarena Solís-Maldonado, María Paz Miró, Aníbal I Acuña, Adriana Covarrubias-Pinto, Anitsi Loaiza, Gonzalo Mayorga, Felipe A Beltrán, Carlos Cepeda, Michael S Levine, Ilona I Concha, Luis Federico Bátiz, Mónica A Carrasco, Maite A Castro
AIMS: Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive abnormalities in cognitive function, mental state, and motor control. HD is characterized by a failure in brain energy metabolism. It has been proposed that monocarboxylates, such as lactate, support brain activity. During neuronal synaptic activity, ascorbic acid released from glial cells stimulates lactate and inhibits glucose transport. The aim of this study was to evaluate the expression and function of monocarboxylate transporters (MCTs) in two HD models...
April 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29582333/influence-of-post-transplant-mucosal-associated-invariant-t-cell-recovery-on-the-development-of-acute-graft-versus-host-disease-in-allogeneic-bone-marrow-transplantation
#20
Koji Kawaguchi, Katsutsugu Umeda, Eitaro Hiejima, Atsushi Iwai, Masamitsu Mikami, Seishiro Nodomi, Satoshi Saida, Itaru Kato, Hidefumi Hiramatsu, Takahiro Yasumi, Ryuta Nishikomori, Tadakazu Kondo, Akifumi Takaori-Kondo, Toshio Heike, Souichi Adachi
Mucosal-associated invariant T (MAIT) and invariant natural killer T (iNKT) cells are T cell subpopulations that possess innate-like properties. We examined the impact of post-hematopoietic stem cell transplantation (HSCT) MAIT and iNKT cell recovery on the clinical outcomes of 69 patients who underwent allogeneic HSCT at Kyoto University Hospital. Multivariate analyses identified the absolute number of MAIT cells (< 0.48/μL on day 60 post-HSCT) as the sole independent risk factor for grade I-IV and grade II-IV acute graft-versus-host disease (aGVHD) among patients who underwent bone marrow transplantation; no correlation was observed between post-HSCT iNKT cell recovery and the development of aGVHD...
March 26, 2018: International Journal of Hematology
keyword
keyword
18374
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"