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https://www.readbyqxmd.com/read/28939453/bone-marrow-wt1-levels-in-allogeneic-hematopoietic-stem-cell-transplant-hct-for-acute-myeloid-leukemia-and-myelodysplasia-clinically-relevant-time-points-and-100-copies-threshold-value
#1
Josep F Nomdedéu, Albert Esquirol, Maite Carricondo, Marta Pratcorona, Montserrat Hoyos, Ana Garrido, Miguel Rubio, Elena Bussaglia, Irene García-Cadenas, Camino Estivill, Salut Brunet, Rodrigo Martino, Jorge Sierra
The outcome of allogeneic hematopoietic stem cell transplant (HCT) in patients with myeloid malignancies is better in those without minimal residual disease (MRD) than in those with MRD+ as assessed by multiparametric flow cytometry (MPFC). WT1 quantitation has also been used to assess the probability of relapse in acute myeloid leukemia treated with chemotherapy. We analyzed the clinical value of normalized bone marrow WT1 levels as a measure of the expanded myeloid progenitor compartment in a consecutive series of 193 adult patients with myeloid malignancies who underwent HCT...
September 19, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28926962/anti-nkg2d-mab-a-new-treatment-for-crohn-s-disease
#2
REVIEW
Kasper Vadstrup, Flemming Bendtsen
Crohn's disease (CD) and ulcerative colitis (UC) are immunologically-mediated, debilitating conditions resulting from destructive inflammation of the gastrointestinal tract. The pathogenesis of IBD is incompletely understood, but is considered to be the result of an abnormal immune response with a wide range of cell types and proteins involved. Natural Killer Group 2D (NKG2D) is an activating receptor constitutively expressed on human Natural Killer (NK), γδ T, mucosal-associated invariant T (MAIT), CD56⁺ T, and CD8⁺ T cells...
September 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28922750/identification-of-iridoid-glucoside-transporters-in-catharanthus-roseus
#3
Bo Larsen, Victoria L Fuller, Jacob Pollier, Alex Van Moerkercke, Fabian Schweizer, Richard Payne, Maite Colinas, Sarah E O'Connor, Alain Goossens, Barbara A Halkier
Monoterpenoid indole alkaloids (MIAs) are plant defense compounds and high-value pharmaceuticals. Biosynthesis of the universal MIA precursor, secologanin, is organized between internal phloem-associated parenchyma (IPAP) and epidermis cells. Transporters for intercellular transport of proposed mobile pathway intermediates have remained elusive. Screening of an Arabidopsis thaliana transporter library expressed in Xenopus oocytes identified AtNPF2.9 as a putative iridoid glucoside importer. Eight orthologs were identified in Catharanthus roseus, of which three, CrNPF2...
September 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28922472/mirna-506-promotes-primary-biliary-cholangitis-like-features-in-cholangiocytes-and-immune-activation
#4
Oihane Erice, Patricia Munoz-Garrido, Javier Vaquero, Maria J Perugorria, Maite G Fernandez-Barrena, Elena Saez, Alvaro Santos-Laso, Ander Arbelaiz, Raul Jimenez-Agüero, Joaquin Fernandez-Irigoyen, Enrique Santamaria, Verónica Torrano, Arkaitz Carracedo, Meenakshisundaram Ananthanarayanan, Marco Marzioni, Jesus Prieto, Ulrich Beuers, Ronald P Oude Elferink, Nicholas F LaRusso, Luis Bujanda, Jose J G Marin, Jesus M Banales
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease associated with autoimmune phenomena targeting intrahepatic bile duct cells (cholangiocytes). Although PBC etiopathogenesis still remains obscure, development of anti-mitochondrial auto-antibodies against pyruvate dehydrogenase complex-E2 (PDC-E2) is a common feature. MicroRNA (miR) dysregulation occurs in liver and immune cells of PBC patients, but their functional relevance is largely unknown. We previously reported that miR-506 is overexpressed in PBC cholangiocytes and directly targets both Cl(-) /HCO3(-) anion exchanger 2 (AE2) and type III inositol 1,4,5-trisphosphate receptor (InsP3R3), leading to cholestasis...
September 18, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28922408/the-role-of-the-pi3k-akt-signaling-pathway-in-the-developmental-competence-of-bovine-oocytes
#5
Gabriella Mamede Andrade, Juliano Coelho da Silveira, Claudia Perrini, Maite Del Collado, Samuel Gebremedhn, Dawit Tesfaye, Flávio Vieira Meirelles, Felipe Perecin
The ovarian follicle encloses oocytes in a microenvironment throughout their growth and acquisition of competence. Evidence suggests a dynamic interplay among follicular cells and oocytes, since they are constantly exchanging "messages". We dissected bovine ovarian follicles and recovered follicular cells (FCs-granulosa and cumulus cells) and cumulus-oocyte complexes (COCs) to investigate whether the PI3K-Akt signaling pathway impacted oocyte quality. Following follicle rupture, COCs were individually selected for in vitro cultures to track the follicular cells based on oocyte competence to reach the blastocyst stage after parthenogenetic activation...
2017: PloS One
https://www.readbyqxmd.com/read/28921542/pathogen-inactivation-of-dengue-virus-in-red-blood-cells-using-amustaline-and-glutathione
#6
Maite Aubry, Andrew Laughhunn, Felicia Santa Maria, Marion C Lanteri, Adonis Stassinopoulos, Didier Musso
BACKGROUND: Dengue virus (DENV) is an arbovirus primarily transmitted through mosquito bite; however, DENV transfusion-transmitted infections (TTIs) have been reported and asymptomatic DENV RNA-positive blood donors have been identified in endemic countries. DENV is considered a high-risk pathogen for blood safety. One of the mitigation strategies to prevent arbovirus TTIs is pathogen inactivation. In this study we demonstrate that the amustaline and glutathione (S-303/GSH) treatment previously found effective against Zika virus in red blood cells (RBCs) is also effective in inactivating DENV...
September 16, 2017: Transfusion
https://www.readbyqxmd.com/read/28912775/shared-and-distinct-phenotypes-and-functions-of-human-cd161-v%C3%AE-7-2-t-cell-subsets
#7
Ayako Kurioka, Aminu S Jahun, Rachel F Hannaway, Lucy J Walker, Joannah R Fergusson, Eva Sverremark-Ekström, Alexandra J Corbett, James E Ussher, Christian B Willberg, Paul Klenerman
Human mucosal-associated invariant T (MAIT) cells are an important T cell subset that are enriched in tissues and possess potent effector functions. Typically such cells are marked by their expression of Vα7.2-Jα33/Jα20/Jα12 T cell receptors, and functionally they are major histocompatibility complex class I-related protein 1 (MR1)-restricted, responding to bacterially derived riboflavin synthesis intermediates. MAIT cells are contained within the CD161++ Vα7.2+ T cell population, the majority of which express the CD8 receptor (CD8+), while a smaller fraction expresses neither CD8 or CD4 coreceptor (double negative; DN) and a further minority are CD4+...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28889862/genetic-dna-profile-in-urine-and-hair-follicles-from-patients-who-have-undergone-allogeneic-hematopoietic-stem-cell-transplantation
#8
Ana Santurtún, José A Riancho, Maite Santurtún, Carlos Richard, M Mercedes Colorado, Mayte García Unzueta, María T Zarrabeitia
Biological samples from patients who have undergone allogeneic hematopoietic stem cell transplantation (HSCT) constitute a challenge for individual identification. In this study we analyzed the genetic profiles (by the amplification of 15 autosomic STRs) of HSCT patients found in different types of samples (blood, hair and urine) that may be the source of DNA in civil or criminal forensic cases. Our results show that while in hair follicles the donor component was not detected in any patient, thus being a reliable source of biological material for forensic identification, mixed chimerism was detected in urine samples from all patient, and no correlation was found between the time elapsed from the transplant and the percentage of chimerism...
September 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/28877992/activation-of-human-mucosal-associated-invariant-t-cells-induces-cd40l-dependent-maturation-of-monocyte-derived-and-primary-dendritic-cells
#9
Mariolina Salio, Olivier Gasser, Claudia Gonzalez-Lopez, Anne Martens, Natacha Veerapen, Uzi Gileadi, Jacob G Verter, Giorgio Napolitani, Regan Anderson, Gavin Painter, Gurdyal S Besra, Ian F Hermans, Vincenzo Cerundolo
Mucosal-associated invariant T (MAIT) cells are innate T cells that recognize intermediates of the vitamin B2 biosynthetic pathway presented by the monomorphic MR1 molecule. It remains unclear whether, in addition to their cytolytic activity that is important in antimicrobial defense, MAIT cells have immune-modulatory functions that could enhance dendritic cell (DC) maturation. In this study, we investigated the molecular mechanisms dictating the interactions between human MAIT cells and DCs and demonstrate that human MAIT cells mature monocyte-derived and primary DCs in an MR1- and CD40L-dependent manner...
September 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28877474/long-noncoding-rna-purpl-suppresses-basal-p53-levels-and-promotes-tumorigenicity-in-colorectal-cancer
#10
Xiao Ling Li, Murugan Subramanian, Matthew F Jones, Ritu Chaudhary, Deepak K Singh, Xinying Zong, Berkley Gryder, Sivasish Sindri, Min Mo, Aaron Schetter, Xinyu Wen, Swetha Parvathaneni, Dickran Kazandjian, Lisa M Jenkins, Wei Tang, Fathi Elloumi, Jennifer L Martindale, Maite Huarte, Yuelin Zhu, Ana I Robles, Susan M Frier, Frank Rigo, Maggie Cam, Stefan Ambs, Sudha Sharma, Curtis C Harris, Mary Dasso, Kannanganattu V Prasanth, Ashish Lal
Basal p53 levels are tightly suppressed under normal conditions. Disrupting this regulation results in elevated p53 levels to induce cell cycle arrest, apoptosis, and tumor suppression. Here, we report the suppression of basal p53 levels by a nuclear, p53-regulated long noncoding RNA that we termed PURPL (p53 upregulated regulator of p53 levels). Targeted depletion of PURPL in colorectal cancer cells results in elevated basal p53 levels and induces growth defects in cell culture and in mouse xenografts. PURPL associates with MYBBP1A, a protein that binds to and stabilizes p53, and inhibits the formation of the p53-MYBBP1A complex...
September 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/28870466/il-12-and-il-7-synergise-to-control-mait-cell-cytotoxic-responses-to-bacterial-infection
#11
Joshua C Wallington, Anthony P Williams, Karl J Staples, Tom M A Wilkinson
BACKGROUND: Bacterial respiratory tract infections and exacerbations of chronic lung diseases are commonly caused by nontypeable Haemophilus influenzae (NTHi). Cell-mediated cytotoxicity may be key to controlling infection, but the responses of NTHi-specific T cell populations are not well understood. Mucosal-associated invariant T (MAIT) cells are a recently-discovered, innate-like subset of T cells with cytotoxic function, whose role in lung immunity is unclear. OBJECTIVE: The aim of this study was to determine the mechanisms behind conventional T and MAIT cell cytotoxic responses to NTHi...
September 1, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28868514/cd161-expression-on-mucosa-associated-invariant-t-cells-is-reduced-in-hiv-infected-subjects-undergoing-antiretroviral-therapy-who-do-not-recover-cd4-t-cells
#12
Michael L Freeman, Stephen R Morris, Michael M Lederman
BACKGROUND: Mucosa-associated invariant T (MAIT) cells are a recently identified class of innate-like T cells that are involved in the mucosal immune response. MAIT cells are characterized by expression of TCR Vα7.2 and CD161. In HIV infection, there is a profound early loss of MAIT cells from the circulation that never fully recovers, even after prolonged viral control with antiretroviral therapy (ART). METHODS: We analyzed PBMCs from fresh whole blood from HIV-negative or ART-treated HIV-positive donors with full (Immune Success) or impaired (Immune Failure) CD4(+) T- cell recovery by flow cytometry for T-cell markers, TCR Vα7...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28864849/maximal-exercise-increases-mucosal-associated-invariant-t-cell-frequency-and-number-in-healthy-young-men
#13
Erik D Hanson, Eli Danson, Catriona V Nguyen-Robertson, Jackson J Fyfe, Nigel K Stepto, David B Bartlett, Samy Sakkal
PURPOSE: Mucosal associated invariant T (MAIT) cells have properties of the innate and acquired immune systems. While the response to vigorous exercise has been established for most leukocytes, MAIT cells have not been investigated. Therefore, the purpose was to determine if MAIT cell lymphocytosis occurs with acute maximal aerobic exercise and if this response is influenced by exercise duration, cardiovascular fitness, or body composition. METHODS: Twenty healthy young males with moderate fitness levels performed an extended graded exercise test until volitional fatigue...
September 1, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28860598/wfs1-deficient-rats-develop-primary-symptoms-of-wolfram-syndrome-insulin-dependent-diabetes-optic-nerve-atrophy-and-medullary-degeneration
#14
Mario Plaas, Kadri Seppa, Riin Reimets, Toomas Jagomäe, Maarja Toots, Tuuliki Koppel, Tuuli Vallisoo, Mait Nigul, Indrek Heinla, Riho Meier, Allen Kaasik, Andres Piirsoo, Miriam A Hickey, Anton Terasmaa, Eero Vasar
Wolfram syndrome (WS) is a rare autosomal-recessive disorder that is caused by mutations in the WFS1 gene and is characterized by juvenile-onset diabetes, optic atrophy, hearing loss and a number of other complications. Here, we describe the creation and phenotype of Wfs1 mutant rats, in which exon 5 of the Wfs1 gene is deleted, resulting in a loss of 27 amino acids from the WFS1 protein sequence. These Wfs1-ex5-KO232 rats show progressive glucose intolerance, which culminates in the development of diabetes mellitus, glycosuria, hyperglycaemia and severe body weight loss by 12 months of age...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28840790/a-new-rhodopsin-influences-light-dependent-daily-activity-patterns-of-fruit-flies
#15
Christa Kistenpfennig, Rudi Grebler, Maite Ogueta, Christiane Hermann-Luibl, Matthias Schlichting, Ralf Stanewsky, Pingkalai R Senthilan, Charlotte Helfrich-Förster
Rhodopsin 7 ( Rh7), a new invertebrate Rhodopsin gene, was discovered in the genome of Drosophila melanogaster in 2000, but its function has remained elusive. We generated an Rh7 null mutant ( Rh7(0)) by P element-mediated mutagenesis and found that an absence of Rh7 had significant effects on fly activity patterns during light-dark (LD) cycles: Rh7(0) mutants exhibited less morning activity and a longer siesta than wild-type controls. Consistent with these results, we found that Rh7 appears to be expressed in a few dorsal clock neurons that have been previously implicated in the control of the siesta...
August 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28834752/clathrin-independent-endocytosis-suppresses-cancer-cell-blebbing-and-invasion
#16
Mikkel Roland Holst, Maite Vidal-Quadras, Elin Larsson, Jie Song, Madlen Hubert, Jeanette Blomberg, Magnus Lundborg, Maréne Landström, Richard Lundmark
Cellular blebbing, caused by local alterations in cell-surface tension, has been shown to increase the invasiveness of cancer cells. However, the regulatory mechanisms balancing cell-surface dynamics and bleb formation remain elusive. Here, we show that an acute reduction in cell volume activates clathrin-independent endocytosis. Hence, a decrease in surface tension is buffered by the internalization of the plasma membrane (PM) lipid bilayer. Membrane invagination and endocytosis are driven by the tension-mediated recruitment of the membrane sculpting and GTPase-activating protein GRAF1 (GTPase regulator associated with focal adhesion kinase-1) to the PM...
August 22, 2017: Cell Reports
https://www.readbyqxmd.com/read/28807929/human-mucosal-associated-invariant-t-mait-cells-possess-capacity-for-b-cell-help
#17
Michael S Bennett, Shubhanshi Trivedi, Anita S Iyer, J Scott Hale, Daniel T Leung
Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell subset, restricted by the nonclassic MHC class I-related protein MR1 and enriched at mucosal sites. Human studies have shown an association between MAIT cells and pathogen-specific antibody responses. In this study, we investigate the effect of human MAIT cells on B cells ex vivo. We found that supernatants from microbe- or cytokine-stimulated MAIT cells, when added to purified autologous B cells, increase frequencies of plasmablasts and promote IgA, IgG, and IgM production...
August 14, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28798979/mucosa-associated-invariant-t-cells-infiltrate-hepatic-metastases-in-patients-with-colorectal-carcinoma-but-are-rendered-dysfunctional-within-and-adjacent-to-tumor-microenvironment
#18
Christopher R Shaler, Mauro E Tun-Abraham, Anton I Skaro, Khashayarsha Khazaie, Alexandra J Corbett, Tina Mele, Roberto Hernandez-Alejandro, S M Mansour Haeryfar
Mucosa-associated invariant T (MAIT) cells are innate-like T lymphocytes that are unusually abundant in the human liver, a common site of colorectal carcinoma (CRC) metastasis. However, whether they contribute to immune surveillance against colorectal liver metastasis (CRLM) is essentially unexplored. In addition, whether MAIT cell functions can be impacted by chemotherapy is unclear. These are important questions given MAIT cells' potent immunomodulatory and inflammatory properties. Herein, we examined the frequencies and functions of peripheral blood, healthy liver tissue, tumor-margin and tumor-infiltrating MAIT cells in 21 CRLM patients who received no chemotherapy, FOLFOX, or a combination of FOLFOX and Avastin before they underwent liver resection...
August 10, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28792648/mait-cell-frequency-and-function-in-blood-and-liver-of-hcv-mono-and-hcv-hiv-co-infected-patients-with-advanced-fibrosis
#19
Boris J B Beudeker, Gertine W van Oord, Joop E Arends, Julian Schulze Zur Wiesch, Marieke S van der Heide, Robert J de Knegt, Annelies Verbon, Andre Boonstra, Mark A A Claassen
BACKGROUND & AIMS: Mucosal-associated invariant T (MAIT) cells are important innate T-cells with anti-microbial and immunoregulatory activity, recently found to be depleted in blood of patients with HIV and HCV mono-infections. In this study, we assessed the impact of HIV, HCV and HCV/HIV co-infection on circulating and intrahepatic MAIT-cells and correlations with liver fibrosis. METHODS: In this cross-sectional study, 9 healthy subjects, 9 HIV, 20 HCV and 22 HCV/HIV co-infected patients were included...
August 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28789524/glucuronidated-flavonoids-in-neurological-protection-structural-analysis-and-approaches-for-chemical-and-biological-synthesis
#20
REVIEW
Maite Docampo, Adiji Olubu, Xiaoqiang Wang, Giulio Pasinetti, Richard A Dixon
Both plant and mammalian cells express glucuronosyltransferases that catalyze glucuronidation of polyphenols such as flavonoids and other small molecules. Oral administration of select polyphenolic compounds leads to the accumulation of the corresponding glucuronidated metabolites at μM and sub-μM concentrations in the brain, associated with amelioration of a range of neurological symptoms. Determining the mechanisms whereby botanical extracts impact cognitive wellbeing and psychological resiliency will require investigation of the modes of action of the brain-targeted metabolites...
September 6, 2017: Journal of Agricultural and Food Chemistry
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