keyword
MENU ▼
Read by QxMD icon Read
search

Mammary gland tumor review

keyword
https://www.readbyqxmd.com/read/29772965/association-of-surgical-approach-with-complication-rate-progression-free-survival-time-and-disease-specific-survival-time-in-cats-with-mammary-adenocarcinoma-107-cases-1991-2014
#1
Francesco Gemignani, Philipp D Mayhew, Michelle A Giuffrida, Jason Palaigos, Jeffrey J Runge, David E Holt, Nicholas A Robertson, Bernard Seguin, Meaghan Walker, Ameet Singh, Julius M Liptak, Giorgio Romanelli, Marina Martano, Sarah E Boston, Cassie Lux, Roberto Busetto, William T N Culp, Katherine A Skorupski, Jenna H Burton
OBJECTIVE To evaluate potential associations between surgical approach and complication rate, progression-free survival time, and disease-specific survival time in cats with mammary adenocarcinoma. DESIGN Retrospective case series. ANIMALS 107 client-owned cats. PROCEDURES Medical records of cats that underwent surgical excision of mammary adenocarcinoma by means of a unilateral or bilateral (staged or single-session) mastectomy at 9 hospitals between 1991 and 2014 were reviewed. Relevant clinicopathologic data and details of surgical and adjuvant treatments were recorded...
June 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29734696/mammary-stem-cells-and-breast-cancer-stem-cells-molecular-connections-and-clinical-implications
#2
REVIEW
Toni Celià-Terrassa
Cancer arises from subpopulations of transformed cells with high tumor initiation and repopulation ability, known as cancer stem cells (CSCs), which share many similarities with their normal counterparts. In the mammary gland, several studies have shown common molecular regulators between adult mammary stem cells (MaSCs) and breast cancer stem cells (bCSCs). Cell plasticity and self-renewal are essential abilities for MaSCs to maintain tissue homeostasis and regenerate the gland after pregnancy. Intriguingly, these properties are similarly executed in breast cancer stem cells to drive tumor initiation, tumor heterogeneity and recurrence after chemotherapy...
May 4, 2018: Biomedicines
https://www.readbyqxmd.com/read/29669190/analysis-of-histologic-follow-up-and-risk-of-malignancy-for-salivary-gland-neoplasm-of-uncertain-malignant-potential-proposed-by-the-milan-system-for-reporting-salivary-gland-cytopathology
#3
Haiyan Liu, Clarissa Ljungren, Fan Lin, Matthew A Zarka, Longwen Chen
BACKGROUND: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. The objective of this study was to assess the risk of malignancy (ROM) of NUMP. METHODS: A retrospective analysis was conducted on 656 salivary gland fine-needle aspiration specimens from 2010 to 2016...
April 18, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29651417/aging-mouse-models-reveal-complex-tumor-microenvironment-interactions-in-cancer-progression
#4
REVIEW
Hidetoshi Mori, Robert D Cardiff, Alexander D Borowsky
Mouse models and genetically engineered mouse models (GEMM) are essential experimental tools for the understanding molecular mechanisms within complex biological systems. GEMM are especially useful for inferencing phenocopy information to genetic human diseases such as breast cancer. Human breast cancer modeling in mice most commonly employs mammary epithelial-specific promoters to investigate gene function(s) and, in particular, putative oncogenes. Models are specifically useful in the mammary epithelial cell in the context of the complete mammary gland environment...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29600163/the-role-of-steroid-hormones-in-breast-and-effects-on-cancer-stem-cells
#5
REVIEW
Denis G Alferez, Bruno M Simões, Sacha J Howell, Robert B Clarke
Purpose of Review: This review will discuss how the steroid hormones, estrogen and progesterone, as well as treatments that target steroid receptors, can regulate cancer stem cell (CSC) activity. The CSC theory proposes a hierarchical organization in tumors where at its apex lies a subpopulation of cancer cells endowed with self-renewal and differentiation capacity. Recent Findings: In breast cancer (BC), CSCs have been suggested to play a key role in tumor maintenance, disease progression, and the formation of metastases...
2018: Current Stem Cell Reports
https://www.readbyqxmd.com/read/29563191/the-challenges-of-modelling-hormone-receptor-positive-breast-cancer-in-mice
#6
Berna Ozdemir, Georgios Sflomos, Cathrin Brisken
Estrogen receptor positive (ER+) tumors account for 70 to 80 % of all breast cancer (BC) cases and are characterized by estrogen dependency for their growth. Endocrine therapies using estrogen receptor antagonists or aromatase inhibitors represent a key component of the standard of care for these tumors. The occurrence of de novo or acquired resistance to estrogen withdrawal represents an important clinical problem, impacting on patient survival. In addition, despite an initially favourable outcome, a part of ER+ BC patients present with disease recurrence locally or at distant sites years or even decades after apparent remission...
March 21, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29560700/gastric-granular-cell-tumor-in-a-youth-excised-by-endoscopic-submucosal-dissection-a-case-report-and-literature-review
#7
Hiroaki Takaya, Hideto Kawaratani, Miki Kaneko, Soichi Takeda, Yasuhiko Sawada, Mitsuteru Kitade, Kei Moriya, Tadashi Namisaki, Masayoshi Sawai, Akira Mitoro, Junichi Yamao, Hitoshi Yoshiji
Granular cell tumors (GCTs) usually develop in patients aged 30-50 years in the skin, tongue, and mammary gland, with 5-9% of GCTs occurring on the esophagus, ascending colon, and cecum. We report a case of gastric GCT in a 16-year-old male who presented with nausea and abdominal discomfort. Esophagogastroduodenoscopy (EGD) revealed an elastic hard and yellowish submucosal tumor of the gastric cardia anterior wall. GCT was suspected upon biopsy ; after total endoscopic submucosal dissection, histology of the resected tumor confirmed the diagnosis...
April 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29531003/mammary-analogue-secretory-carcinoma-of-minor-salivary-glands-a-rare-case-series-and-review-of-the-literature
#8
Suvra Roy, Karan Saluja, Hui Zhu, Bihong Zhao
Mammary analogue secretory carcinoma (MASC) is a rare salivary gland tumor that recapitulates the cytomorphology, immunophenotype, and genetics of an equally rare malignancy of the breast, secretory carcinoma (SC). Here we present two cases of MASC of minor salivary glands from a single institutional experience.
January 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29487996/genetic-variation-in-sensitivity-to-estrogens-and-breast-cancer-risk
#9
D Joseph Jerry, James D Shull, Darryl L Hadsell, Monique Rijnkels, Karen A Dunphy, Sallie S Schneider, Laura N Vandenberg, Prabin Dhangada Majhi, Celia Byrne, Amy Trentham-Dietz
Breast cancer risk is intimately intertwined with exposure to estrogens. While more than 160 breast cancer risk loci have been identified in humans, genetic interactions with estrogen exposure remain to be established. Strains of rodents exhibit striking differences in their responses to endogenous ovarian estrogens (primarily 17β-estradiol). Similar genetic variation has been observed for synthetic estrogen agonists (ethinyl estradiol) and environmental chemicals that mimic the actions of estrogens (xenoestrogens)...
February 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29471575/-breast-cancer-diagnostics-and-therapy-the-most-important-facts-for-internists
#10
Ulrich Hamann, Christine Ankel
LEARNING OBJECTIVES:  After reviewing this article, the participant should be able to: 1. Understand the epidemiology of breast cancer, its incidence and impact. 2. Appreciate the importance of early diagnosis and treatment. 3. Understand the concept of comprehensive breast cancer management and its multidisciplinarity. 4. Be knowledgeable about the entire process required to manage breast cancer, since the early diagnosis until the management of non breast related conditions derived from the treatment...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29389520/the-wnt-signaling-landscape-of-mammary-stem-cells-and-breast-tumors
#11
Caroline M Alexander
Attention has been focused on Wnt signaling in the mouse mammary gland for several decades, firstly by the discovery of several Wnt loci among the oncogenes revealed by MMTV-based insertional mutagenesis screening of mouse mammary gland, and then by the remarkable visualization of Wnt-dependent specification of mammary placodes in embryonic skin. This review aims to summarize the impact of recent data for our understanding of the roles of Wnt signaling in these roles. The amount and identity of both familiar and novel Wnt signaling components is examined for mouse mammary epithelial cells...
January 2018: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29142456/secretory-carcinoma-impact-of-translocation-and-gene-fusions-on-salivary-gland-tumor
#12
Ryoko Inaki, Masanobu Abe, Liang Zong, Takahiro Abe, Aya Shinozaki-Ushiku, Tetsuo Ushiku, Kazuto Hoshi
Secretory carcinoma (SC), previously described as mammary analogue secretory carcinoma (MASC), is a recently described salivary gland tumor which morphologically resembles mammary secretory carcinoma. The first description of SC/MASC, reported by Skálová et al . in 2010, was as a rare salivary carcinoma imitating secretory carcinoma of the breast. SC/MASC is a unique salivary gland tumor with morphological overlap with acinic cell carcinoma (AciCC), mucoepidermoid carcinoma (MEC), and adenocarcinoma not otherwise specified (ADC-NOS)...
October 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/29128804/hexachlorobenzene-as-a-persistent-organic-pollutant-toxicity-and-molecular-mechanism-of-action
#13
REVIEW
Beata Starek-Świechowicz, Bogusława Budziszewska, Andrzej Starek
Hexachlorobenzene (HCB) is an organochlorine pesticide widely distributed in the environment. Chronic exposure of humans to HCB leads to a number of effects, such as triggering of porphyria, microsomal enzyme induction, thyroid dysfunctions, neurological symptoms, and immunological disorders. In animals, HCB induced hepatic porphyria, neurotoxic effects, and toxic effects on the thyroid function, reproductive system, and immune system. HCB as a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR) is a hormonal disruptor...
December 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29076877/the-role-of-molecular-testing-in-the-differential-diagnosis-of-salivary-gland-carcinomas
#14
Alena Skálová, Göran Stenman, Roderick H W Simpson, Henrik Hellquist, David Slouka, Tomas Svoboda, Justin A Bishop, Jennifer L Hunt, Ken-Ichi Nibu, Alessandra Rinaldo, Vincent Vander Poorten, Kenneth O Devaney, Petr Steiner, Alfio Ferlito
Salivary gland neoplasms are a morphologically heterogenous group of lesions that are often diagnostically challenging. In recent years, considerable progress in salivary gland taxonomy has been reached by the discovery of tumor type-specific fusion oncogenes generated by chromosome translocations. This review describes the clinicopathologic features of a selected group of salivary gland carcinomas with a focus on their distinctive genomic characteristics. Mammary analog secretory carcinoma is a recently described entity characterized by a t(12;15)(p13;q25) translocation resulting in an ETV6-NTRK3 fusion...
February 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29045292/ovarian-metastases-of-breast-cancers-with-signet-ring-cells-a-report-of-17-cases-including-14-krukenberg-tumors
#15
Jennifer A Bennett, Robert H Young, Ai-Ying Chuang, Melinda F Lerwill
Krukenberg tumor, defined as metastatic adenocarcinoma to the ovary containing at least 10% signet ring cells, usually arises from the stomach but can also originate from other sites. We reviewed 17 metastatic breast carcinomas to the ovary with signet ring cells to potentially identify features indicative of mammary origin as opposed to other possible primary sites. The patients ranged from 41 to 76 (mean, 53.6) yr. Fourteen had a prior history of invasive breast carcinoma (invasive ductal carcinoma, 4; invasive lobular carcinoma, 3; adenocarcinoma not otherwise specified, 3; carcinoma with ductal and lobular features, 2; and unspecified carcinoma, 2) and metastases were identified 2 to 284 (mean, 79) mo after the original diagnosis...
October 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28987728/environmental-chemicals-and-breast-cancer-an-updated-review-of-epidemiological-literature-informed-by-biological-mechanisms
#16
REVIEW
Kathryn M Rodgers, Julia O Udesky, Ruthann A Rudel, Julia Green Brody
BACKGROUND: Many common environmental chemicals are mammary gland carcinogens in animal studies, activate relevant hormonal pathways, or enhance mammary gland susceptibility to carcinogenesis. Breast cancer's long latency and multifactorial etiology make evaluation of these chemicals in humans challenging. OBJECTIVE: For chemicals previously identified as mammary gland toxicants, we evaluated epidemiologic studies published since our 2007 review. We assessed whether study designs captured relevant exposures and disease features suggested by toxicological and biological evidence of genotoxicity, endocrine disruption, tumor promotion, or disruption of mammary gland development...
January 2018: Environmental Research
https://www.readbyqxmd.com/read/28929038/drainage-after-modified-radical-mastectomy-a-methodological-mini-review
#17
REVIEW
George S Stoyanov, Dragostina Tsocheva, Katerina Marinova, Emil Dobrev, Rumen Nenkov
Breast cancer is a socially relevant group of malignant conditions of the mammary gland, affecting both males and females. Most commonly the surgical approach of choice is a modified radical mastectomy (MRM), due to it allowing for both the removal of the main tumor mass and adjacent glandular tissue, which are suspected of infiltration and multifocality of the process, and a sentinel axillary lymph node removal. Most common post-surgical complications following MRM are the formation of a hematoma, the infection of the surgical wound and the formation of a seroma...
July 10, 2017: Curēus
https://www.readbyqxmd.com/read/28794644/the-rank-rankl-opg-system-in-tumorigenesis-and-metastasis-of-cancer-stem-cell-potential-targets-for-anticancer-therapy
#18
REVIEW
Mekonnen Sisay, Getnet Mengistu, Dumessa Edessa
The molecular triad involving receptor activator of nuclear factor kβ (RANK)/RANK ligand (RANKL)/osteoprotegerin cytokine system has been well implicated in several physiological and pathological processes including bone metabolism, mammary gland development, regulation of the immune function, tumorigenesis and metastasis of cancer stem cell, thermoregulation, and vascular calcification. However, this review aimed to summarize several original and up-to-date articles focusing on the role of this signaling system in cancer cell development and metastasis as well as potential therapeutic agents targeting any of the three tumor necrotic factor super family proteins and/or their downstream signaling pathways...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28754015/human-chorionic-gonadotropin-and-breast-cancer
#19
REVIEW
Susanne Schüler-Toprak, Oliver Treeck, Olaf Ortmann
Breast cancer is well known as a malignancy being strongly influenced by female steroids. Pregnancy is a protective factor against breast cancer. Human chorionic gonadotropin (HCG) is a candidate hormone which could mediate this antitumoral effect of pregnancy. For this review article, all original research articles on the role of HCG in breast cancer were considered, which are listed in PubMed database and were written in English. The role of HCG in breast cancer seems to be a paradox. Placental heterodimeric HCG acts as a protective agent by imprinting a permanent genomic signature of the mammary gland determining a refractory condition to malignant transformation which is characterized by cellular differentiation, apoptosis and growth inhibition...
July 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28631716/-anogenital-mammary-like-glands-and-related-diseases-part-2-malignant-tumors-of-the-anogenital-glands
#20
REVIEW
A M Konstantinova, I E Belousova, D Kacerovska, M Michal, K V Shelekhova, D V Kazakov
Mammary-like glands are a normal anatomical component of the anogenital region and can give rise to many benign and malignant tumors that morphologically mimic the similar diseases of the breast. The literature review is complemented by a description of 199 cases of malignant tumors of mammary-like glands. The paper presents the clinical and morphological characteristics of various malignant tumors of mammary-like glands, including extramammary Paget's disease, ductal, tubulolobular, adenoid cystic adenocarcinoma, low-grade phyllodes tumor, etc...
2017: Arkhiv Patologii
keyword
keyword
18371
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"