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Breast cancer review

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https://www.readbyqxmd.com/read/29656432/calcium-channel-blockers-and-the-incidence-of-breast-and-prostate-cancer-a-meta-analysis
#1
A A Thakur, X Wang, M M Garcia-Betancourt, R A Forse
WHAT IS KNOWN AND OBJECTIVE: Breast cancer (BCa) and prostate cancer (PCa), both hormone-dependent cancers, are the second leading cause of death in both women and men, respectively. Calcium channel blockers (CCBs) have been thought to increase the risk of cancer by inhibiting calcium signal-mediated apoptosis, but the evidence for this association remains inconclusive. We have reviewed pertinent literature and pooled data to establish a consensus on the relationship of CCB use and the incidence of these two cancers...
April 15, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29656290/psychosocial-cognitive-and-physical-impact-of-elaborate-consultations-and-life-review-in-female-patients-with-non-metastasized-breast-cancer
#2
Anja Thronicke, Matthias Kröz, Antje Merkle, Harald Matthes, Cornelia Herbstreit, Friedemann Schad
No abstract text is available yet for this article.
April 18, 2018: Complementary Medicine Research
https://www.readbyqxmd.com/read/29652946/-impact-of-the-chilean-explicit-guaranties-health-system-ges-on-breast-cancer-treatment
#3
César Del Castillo Sm, M Elena Cabrera C, Lea Derio P, Fancy Gaete V, Gabriel Cavada Ch
Background Breast cancer is the most common malignant tumor in women in the world. In 2005, it was incorporated to the Explicit Guaranties Health System (GES) in Chile. Aim To describe the demographic and clinical characteristics of breast cancer patients and to determine the effect of incorporating these women to GES. Material and Methods Medical records of 5,119 women with breast cancer aged 59 ± 14 years, attended at six public hospitals between 2000 and 2010 were reviewed. Median follow up was 87 months (range 1-182)...
December 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29651638/improvement-in-diagnostic-performance-of-breast-cancer-comparison-between-conventional-digital-mammography-alone-and-conventional-mammography-plus-digital-breast-tomosynthesis
#4
Ryoko Ohashi, Michinobu Nagao, Izumi Nakamura, Takahiro Okamoto, Shuji Sakai
BACKGROUND: The aim of this study was to determine if the diagnostic performance of breast lesion examinations could be improved using both digital breast tomosynthesis (DBT) and conventional digital mammography (CDM). METHODS: Our institutional review board approved the protocol, and patients were provided the opportunity to opt out of the study. A total of 628 patients aged 22-91 years with abnormal screening results or clinical symptoms were consecutively enrolled between June 2015 and March 2016...
April 12, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29651637/an-overview-of-mammographic-density-and-its-association-with-breast-cancer
#5
REVIEW
Shayan Shaghayeq Nazari, Pinku Mukherjee
In 2017, breast cancer became the most commonly diagnosed cancer among women in the US. After lung cancer, breast cancer is the leading cause of cancer-related mortality in women. The breast consists of several components, including milk storage glands, milk ducts made of epithelial cells, adipose tissue, and stromal tissue. Mammographic density (MD) is based on the proportion of stromal, epithelial, and adipose tissue. Women with high MD have more stromal and epithelial cells and less fatty adipose tissue, and are more likely to develop breast cancer in their lifetime compared to women with low MD...
April 12, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29651440/mast-cell-the-neglected-member-of-the-tumor-microenvironment-role-in-breast-cancer
#6
REVIEW
Angélica Aponte-López, Ezequiel M Fuentes-Pananá, Daniel Cortes-Muñoz, Samira Muñoz-Cruz
Mast cells are unique tissue-resident immune cells that secrete a diverse array of biologically active compounds that can stimulate, modulate, or suppress the immune response. Although mounting evidence supports that mast cells are consistently infiltrating tumors, their role as either a driving or an opposite force for cancer progression is still controversial. Particularly, in breast cancer, their function is still under discussion. While some studies have shown a protective role, recent evidence indicates that mast cells enhance blood and lymphatic vessel formation...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29651417/aging-mouse-models-reveal-complex-tumor-microenvironment-interactions-in-cancer-progression
#7
REVIEW
Hidetoshi Mori, Robert D Cardiff, Alexander D Borowsky
Mouse models and genetically engineered mouse models (GEMM) are essential experimental tools for the understanding molecular mechanisms within complex biological systems. GEMM are especially useful for inferencing phenocopy information to genetic human diseases such as breast cancer. Human breast cancer modeling in mice most commonly employs mammary epithelial-specific promoters to investigate gene function(s) and, in particular, putative oncogenes. Models are specifically useful in the mammary epithelial cell in the context of the complete mammary gland environment...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29651384/cell-free-dna-integrity-for-the-monitoring-of-breast-cancer-future-perspectives
#8
REVIEW
Navid Sobhani, Daniele Generali, Fabrizio Zanconati, Marina Bortul, Bruna Scaggiante
Breast cancer (BC) is the most common cancer and the second cause of death in women worldwide. Therapeutic options are increasing, but the response to treatments is not always efficient and the risk of recurrence covers decades. In this perspective, the need to have a proper follow-up for the therapeutic responses and for anticipating recurrence it is urgent in the clinical setting. Liquid biopsy provides the basic principle for a non-invasive method for the routinely monitoring of BC. However, due to the heterogeneity of tumors during onset and progression, the search for tumor DNA mutations of targeted genes in plasma/serum is a limiting factor...
April 10, 2018: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29650809/-molecular-targeted-therapies-for-hereditary-cancer-syndrome
#9
Hideki Shimodaira
Development of molecular targeted drugs has achieved remarkable improvement of systemic cancer therapy. Recently, the several molecular targeted drugs have become available which associated with the status of responsible genes for hereditary cancer syndrome. These drugs would allow to establish specific strategy for hereditary cancer syndrome or sporadic cancers with similar biological phenotype with hereditary cancer. Genetic tests for the diagnosis of hereditary cancer syndrome will have the meaning of biomarker for predicting the efficacy of these molecular targeted drugs...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650282/meeting-the-needs-of-breast-cancer-a-nucleolin-s-perspective
#10
REVIEW
Ana C Gregório, Manuela Lacerda, Paulo Figueiredo, Sérgio Simões, Sérgio Dias, João Nuno Moreira
A major challenge in the management of breast cancer disease has been the development of metastases. Finding new molecular targets and the design of targeted therapeutic approaches to improve the overall survival and quality of life of these patients is, therefore, of great importance. Nucleolin, which is overexpressed in cancer cells and tumor-associated blood vessels, have been implicated in various processes supporting tumorigenesis and angiogenesis. Additionally, its overexpression has been demonstrated in a variety of human neoplasias as an unfavorable prognostic factor, associated with a high risk of relapse and low overall survival...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29649327/evaluation-of-intraoperative-touch-imprint-cytology-on-axillary-sentinel-lymph-nodes-in-invasive-breast-carcinomas-a-retrospective-study-of-1227-patients-comparing-sensitivity-in-the-different-tumor-subtypes
#11
Hafsteinn Ingi Pétursson, Anikó Kovács, Jan Mattsson, Roger Olofsson Bagge
BACKGROUND: Intraoperative evaluation of the axillary sentinel lymph node (SLN) in patients with breast carcinoma reduces the need of re-operations in cases where an axillary completion lymph node dissection (CLND) is indicated. Different methods have been used to determine the SLN status intraoperatively, e.g. frozen section histology (FS) and touch imprint cytology (TIC). The sensitivity of intraoperative TIC examination on SLN is not consistent between different studies and varies according to different tumor histologic subtypes, tumor size and the age of the patient...
2018: PloS One
https://www.readbyqxmd.com/read/29649080/investigating-changes-in-weight-and-body-composition-among-women-in-adjuvant-treatment-for-breast-cancer-a-scoping-review
#12
Birgith Pedersen, Charlotte Delmar, Tamás Lörincz, Ursula Falkmer, Mette Grønkjær
BACKGROUND: Despite several investigations, findings on weight changes during and after adjuvant treatment for breast cancer are diverse and point in several directions. OBJECTIVE: The aims of this study were to investigate changes in weight and body composition associated with contemporary anticancer medication and to examine factors that might influence the assessment and diversity of the findings. METHODS: This article used the method of a scoping review to map the body of literature...
April 12, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29644507/the-impact-of-obesity-on-breast-cancer
#13
REVIEW
Daniel F Argolo, Clifford A Hudis, Neil M Iyengar
The rates of obesity are increasing worldwide and this condition is now recognized as a leading preventable cause of cancer. Several diseases are directly related to obesity, including diabetes, hypertension, atherosclerosis, stroke, musculoskeletal disorders, and a diverse range of malignances-such as breast cancer. Obesity is associated with an increased risk of postmenopausal estrogen receptor-positive breast cancer and worse cancer-related outcomes for all breast tumor subtypes. Several mechanisms have been proposed to contribute to the obesity-cancer link, including high levels of circulating and local estrogens, altered amounts of adipokines (leptin and adiponectin), disrupted insulin/IGF signaling, modifications within the microbiome, and local and systemic effects of inflammation...
April 11, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29644453/analysis-of-factors-predicting-surgical-intervention-and-associated-costs-in-pediatric-breast-masses-a-single-center-study
#14
E Graham Englert, Guillermo Ares, Andrea Henricks, Karen Rychlik, Catherine J Hunter
PURPOSE: Finding a breast mass in a child provokes apprehension in parents, especially in those with a family history of breast cancer. Clinicians must decide between serial imaging or biopsy of the mass. Herein, we identify management differences in those with and without a positive family history, as well as identify cost differences. METHODS: An institutional retrospective review was performed of patients (2-18 years of age) with a diagnosis of breast mass...
April 11, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29644155/stereotactic-body-radiation-therapy-for-pulmonary-oligometastases-arising-from-non-lung-primaries-in-patients-without-extrapulmonary-disease
#15
Michael J Dohopolski, Zachary Horne, David Clump, Steven A Burton, Dwight E Heron
Purpose Stereotactic body radiation therapy (SBRT) is increasingly used in the management of patients with oligometastatic cancers and is under prospective evaluation by the Radiation Therapy Oncology Group (RTOG). Here we report outcomes from a high-volume institution of patients treated with SBRT for pulmonary oligometastases. Materials and methods We conducted a retrospective review of 105 patients who had one to five pulmonary oligometastases (185 lesions) without extrapulmonary disease treated with SBRT from 2002-2014...
February 7, 2018: Curēus
https://www.readbyqxmd.com/read/29629349/knowledge-and-source-of-information-about-early-detection-techniques-of-breast-cancer-among-women-in-iran-a-systematic-review
#16
Salehoddin Bouya, Abbas Balouchi, Sudabeh Ahmadidarehsima, Mahin Badakhsh
Background: An increase of access to knowledge about early detection techniques of breast cancer can reduce this mortality rate. This study aimed to determine the knowledge and source of information about early detection techniques of breast cancer among Iranian women. Methods: Both International (PubMed, Web of Science, and Google Scholar) and national (scientific information database [SID] and Magiran) databases were reviewed launching to September, 2017 to obtain related articles...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29628987/benign-intraductal-papilloma-without-atypia-on-core-needle-biopsy-has-a-low-rate-of-upgrading-to-malignancy-after-excision
#17
Song-Hee Han, Milim Kim, Yul Ri Chung, Bo La Yun, Mijung Jang, Sun Mi Kim, Eunyoung Kang, Eun-Kyu Kim, So Yeon Park
Purpose: The management of benign intraductal papilloma (IDP) without atypia diagnosed on core needle biopsy (CNB) remains controversial. This study was performed to evaluate the rate of upgrading to malignancy or high-risk lesions after excision and to identify factors associated with upgrading using a large series of benign IDP cases without atypia. Methods: We included patients who were diagnosed as having benign IDP without atypia on CNB and underwent surgical or vacuum-assisted excision between 2010 and 2015...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29628986/chronological-improvement-in-survival-of-patients-with-breast-cancer-a-large-scale-single-center-study
#18
Sae Byul Lee, Guiyun Sohn, Jisun Kim, Il Yong Chung, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sung-Bae Kim, Sei-Hyun Ahn
Purpose: This study aimed to chronologically evaluate survival of patients with breast cancer in Korea and investigate the observed changes during the last 20 years. We also sought to determine factors that may influence outcomes and changes in the duration of survival over time. Methods: We retrospectively analyzed a total of 10,988 patients with breast cancer who were treated at our institution between January 1993 and December 2008. We divided the study period into three periods (P1, 1993-1997; P2, 1998-2002; and P3, 2003-2008)...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29628613/locoregional-therapies-for-the-treatment-of-hepatic-metastases-from-breast-and-gynecologic-cancers
#19
REVIEW
Samdeep K Mouli, Ramona Gupta, Neil Sheth, Andrew C Gordon, Robert J Lewandowski
Breast cancer is the most common women's malignancy in the United States and is the second leading cause of cancer death. More than half of patients with breast cancer will develop hepatic metastases; this portends a poorer prognosis. In the appropriately selected patient, there does appear to be a role for curative (surgery, ablation) or palliative (intra-arterial treatments) locoregional therapy. Gynecologic malignancies are less common and metastases to the liver are most often seen in the setting of disseminated disease...
March 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29625911/specialized-second-opinion-interpretations-of-breast-imaging-impact-on-additional-workup-and-management
#20
R Jared Weinfurtner, Bethany Niell, Yasmin Mekhail, Emily Aguila, Leena Kamat
BACKGROUND: Women with breast imaging often seek second opinions at tertiary care centers. Our study measures the frequency of discrepancy between initial and second opinion breast imaging recommendations and evaluates the impact on patient management. MATERIALS AND METHODS: A retrospective chart review was conducted on 504 consecutive patients with second opinion breast radiology interpretations performed by 6 sub-specialized breast radiologists at a dedicated cancer center from January 1, 2014 through September 1, 2014...
March 16, 2018: Clinical Breast Cancer
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