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Breast cancer review

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https://www.readbyqxmd.com/read/29222705/tai-chi-and-qigong-for-cancer-related-symptoms-and-quality-of-life-a-systematic-review-and-meta-analysis
#1
REVIEW
Peter M Wayne, M S Lee, J Novakowski, K Osypiuk, J Ligibel, L E Carlson, R Song
PURPOSE: This study aims to summarize and critically evaluate the effects of Tai Chi and Qigong (TCQ) mind-body exercises on symptoms and quality of life (QOL) in cancer survivors. METHODS: A systematic search in four electronic databases targeted randomized and non-randomized clinical studies evaluating TCQ for fatigue, sleep difficulty, depression, pain, and QOL in cancer patients, published through August 2016. Meta-analysis was used to estimate effect sizes (ES, Hedges' g) and publication bias for randomized controlled trials (RCTs)...
December 8, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29222623/tumor-infiltrating-lymphocytes-in-breast-cancer-patients-with-progressive-disease-during-neoadjuvant-chemotherapy
#2
Jacques Raphael, S Nofech-Mozes, T Paramsothy, N Li, S Gandhi
A minority of breast cancer (BC) patients progress during neoadjuvant chemotherapy (NCT). The aim of this study was to assess the value of Tumor infiltrating lymphocytes (TILs) in such a high-risk population where valid biomarkers are eagerly needed. A retrospective review identified BC patients who either progressed during NCT or achieved a pathologic complete response (pCR). An experienced BC pathologist semi-quantified stromal TILs in pre-treatment core biopsies using hematoxylin and eosin stained slides...
December 8, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29221345/a-rare-mixed-breast-cancer-of-intraductal-and-solid-papillary-with-tubular-carcinoma-histotypes-in-a-young-woman
#3
Xiaohui Zhang, Jie Shi, Yidong Zhou, Feng Mao, Yan Lin, Jinghong Guan, Zhiyong Liang, Qiang Sun
Mixed breast cancer, especially of uncommon breast cancer histotypes, is rare, limiting our understanding of the disease and influencing diagnostic and management outcomes. We report a case of mixed breast cancer, with features of intraductal and solid papillary and tubular carcinomas, which appeared in a young patient. Physical examination, ultrasonography, molybdenum target mammography, and histopathology were performed for a definitive diagnosis. Tumor resection followed by radiotherapy and adjuvant chemotherapy was selected as the therapeutic strategy, and the patient was followed up thrice post treatment...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29220587/fto-gene-affects-obesity-and-breast-cancer-through-similar-mechanisms-a-new-insight-into-the-molecular-therapeutic-targets
#4
M E Akbari, M Gholamalizadeh, S Doaei, F Mirsafa
OBJECTIVES: This review focused on the possible mediatory role of the FTO in the association between obesity and breast cancer. METHOD: All articles published in English from June 1990 to January 2017 were studied. The search terms used were FTO gene, FTO polymorphism, breast cancer, and obesity. Inclusion criteria consisted of assessment of the relationship between FTO polymorphisms and/or FTO expression level with obesity and/or breast cancer as a primary outcome...
December 8, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29220062/community-academic-partnership-to-implement-a-breast-and-cervical-cancer-screening-education-program-in-puerto-rico
#5
Vivian Colón-López, Daisy González, Camille Vélez, Natalie Fernández-Espada, Alana Feldman-Soler, Kelly Ayala-Escobar, Alelí M Ayala-Marín, Marievelisse Soto-Salgado, William A Calo, Angela Pattatucci-Aragón, Marinilda Rivera-Díaz, María E Fernández
OBJECTIVE: To describe how a community-academic partnership between Taller Salud Inc., a community-based organization, and the Puerto Rico Community Cancer Control Outreach Program of the University of Puerto Rico was crucial in the adaptation and implementation of Cultivando La Salud (CLS), an evidencebased educational outreach program designed to increase breast and cervical cancer screening among Hispanic women living in Puerto Rico. This collaboration facilitated the review and adaptation of the CLS intervention to improve cultural appropriateness, relevance, and acceptability for Puerto Rican women...
December 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29219017/eribulin-in-advanced-breast-cancer-safety-efficacy-and-new-perspectives
#6
Ornella Garrone, Emanuela Miraglio, Anna Maria Vandone, Paola Vanella, Daniele Lingua, Marco C Merlano
Eribulin is a synthetic analog of halichondrin B belonging to microtubule-targeted agents with a distinct mechanism of inhibition of microtubule dynamics. This molecule has multiple nonmitotic effects on tumor biology, exhibiting effects on epithelial-mesenchimal transition and tumor vasculature. We review here preclinical and clinical studies on eribulin. The mitotic and nonmitotic effects together with its favorable safety profile make eribulin a unique drug with high potential in the treatment of metastatic breast cancer...
December 2017: Future Oncology
https://www.readbyqxmd.com/read/29218120/characteristics-and-correlates-of-woman-eligible-for-targeted-screening-mammography-in-oman
#7
Mahmood Masud Al Awfi, Obaid Said Al-Hubaishi
Objectives: We sought to determine the characteristics of women eligible for a high-yield screening mammography program in Oman. Methods: We conducted a retrospective review of women who underwent breast cancer screening at the Oman Cancer Association from 22 December 2009 to 6 February 2011. Women with a Breast Imaging Reporting and Data System (BI-RADS) score of 4-5 were compared with those with a score of 1-3 based on well-known breast cancer risk factors using the case-control approach analysis...
November 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29216916/low-level-laser-therapy-photobiomodulation-therapy-for-breast-cancer-related-lymphedema-a-systematic-review
#8
G David Baxter, Lizhou Liu, Simone Petrich, Angela Spontelli Gisselman, Cathy Chapple, Juanita J Anders, Steve Tumilty
BACKGROUND: Breast cancer related lymphedema (BCRL) is a prevalent complication secondary to cancer treatments which significantly impacts the physical and psychological health of breast cancer survivors. Previous research shows increasing use of low level laser therapy (LLLT), now commonly referred to as photobiomodulation (PBM) therapy, for BCRL. This systematic review evaluated the effectiveness of LLLT (PBM) in the management of BCRL. METHODS: Clinical trials were searched in PubMed, AMED, Web of Science, and China National Knowledge Infrastructure up to November 2016...
December 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29215763/breast-cancer-the-translation-of-big-genomic-data-to-cancer-precision-medicine
#9
REVIEW
Siew-Kee Low, Hitoshi Zembutsu, Yusuke Nakamura
Cancer is a complex genetic disease that consequence from the accumulation of genomic alterations, in which germline variations predispose individuals to cancer and somatic alterations initiate and trigger the progression of cancer. For the past two decades, genomic research has advanced remarkably, evolving from single-gene to whole-genome screening by using genome-wide association study (GWAS) and next generation sequencing (NGS) that contributing to big genomic data. International collaborative efforts have contributed in curating these data to identify clinically significant alterations that could be used in the clinical settings...
December 7, 2017: Cancer Science
https://www.readbyqxmd.com/read/29215311/classification-of-breast-cancer-from-ultrasound-imaging-using-a-generic-deep-learning-analysis-software-a-pilot-study
#10
Anton S Becker, Michael Mueller, Elina Stoffel, Magda Marcon, Soleen Ghafoor, Andreas Boss
PURPOSE: To train a generic deep learning software (DLS) to classify breast cancer on ultrasound images and to compare its performance to human readers with variable breast imaging experience. METHODS: In this IRB-approved, HIPAA compliant, retrospective study, all breast ultrasound examinations from January 1, 2014, to December 31, 2014 were reviewed. Patients with postsurgical scars, initially indeterminate, or malignant lesions with histological diagnoses or 2-year follow-up were included...
December 7, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29214870/advances-in-cell-free-protein-array-methods
#11
Xiaobo Yu, Brianne Petritis, Hu Duan, Danke Xu, Joshua LaBaer
Cell-free protein microarrays represent a special form of protein microarray which display proteins made fresh at the time of the experiment, avoiding storage and denaturation. They have been used increasingly in basic and translational research over the past decade to study protein-protein interactions, the pathogen-host relationship, post-translational modifications, and antibody biomarkers of different human diseases. Their role in the first blood-based diagnostic test for early stage breast cancer highlights their value in managing human health...
December 7, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29214416/breast-conserving-surgery-following-neoadjuvant-therapy-a-systematic-review-on-surgical-outcomes
#12
REVIEW
José H Volders, Vera L Negenborn, Pauline E Spronk, Nicole M A Krekel, Linda J Schoonmade, Sybren Meijer, Isabel T Rubio, M Petrousjka van den Tol
PURPOSE: Neoadjuvant chemotherapy (NACT) is increasingly used in breast cancer treatment. One of the main goals of NACT is to reduce the extent of local surgery of the breast and axilla. The aim of this study was to determine surgical outcomes for patients receiving breast-conserving therapy (BCT) after NACT, including margin status plus secondary surgeries, excision volumes, and cosmetic outcomes. METHODS: A systematic review was performed in accordance with PRISMA principles...
December 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29212167/a-nomogram-to-predict-her2-status-in-breast-cancer-patients-with-her2-borderline-disease-as-determined-via-immunohistochemistry
#13
Qianqian Guo, Kai Chen, Xiaojie Lin, Yi Su, Rui Xu, Yan Dai, Chang Qiu, Xue Song, Siying Mao, Qianjun Chen
This study aimed to develop a nomogram to predict fluorescence in situ hybridization (FISH) assay results for HER2-borderline breast cancer as determined via immunohistochemistry (IHC) among patients in China. We reviewed a database of breast cancer patients diagnosed between January 2007 and April 2013 at our institutions. We used logistic regression to develop a nomogram and we used receiver operating characteristic curve analysis and calibration plots to validate our nomogram. In total, 1138, 301 and 344 patients had IHC-determined HER2-negative, HER2-borderline and HER2-positive disease, respectively...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29210805/development-of-a-simple-preoperative-risk-score-for-persistent-pain-after-breast-cancer-surgery-a-prospective-observational-cohort-study
#14
Domitille Dereu, Georges L Savoldelli, Christophe Combescure, Stanislas Mathivon, Benno Rehberg
OBJECTIVES: Persistent postoperative pain concerns 30 to 50% of patients following breast cancer surgery. Studies testing preventive measures, however, have so far failed to produce consistent positive results. If preventive measures could be targeted to a subgroup of patients at high risk of persistent pain, positive results would be more likely. Our aim was to develop a simple risk score predicting persistent pain after breast cancer surgery. METHODS: In a prospective observational cohort study, we tested the predictive ability of a 4 simple items score for persistent pain in 200 patients scheduled for breast cancer surgery...
November 28, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29210319/carcinogenicity-of-ethylene-oxide-key-findings-and-scientific-issues
#15
Jennifer Jinot, Jason M Fritz, Suryanarayana V Vulimiri, Nagalakshmi Keshava
In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) completed an evaluation of the inhalation carcinogenicity of ethylene oxide (EtO) in December 2016. This article reviews key findings and scientific issues regarding the carcinogenicity of EtO in EPA's Carcinogenicity Assessment. EPA's assessment critically reviewed and characterized epidemiologic, laboratory animal, and mechanistic studies pertaining to the human carcinogenicity of EtO, and addressed some key scientific issues such as the analysis of mechanistic data as part of the cancer hazard evaluation and to inform the quantitative risk assessment...
December 6, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29209558/development-and-clinical-application-of-anti-her2-monoclonal-and-bispecific-antibodies-for-cancer-treatment
#16
REVIEW
Shengnan Yu, Qian Liu, Xinwei Han, Shuang Qin, Weiheng Zhao, Anping Li, Kongming Wu
HER2-targeted immunotherapy consists of monoclonal antibodies (e.g. trastuzumab, pertuzumab), bispecific antibodies (e.g. MM-111, ertumaxomab) and activated T cells armed with anti-HER2 bispecific antibody (HER2Bi-aATC). Trastuzumab is a classic drug for the treatment of HER2 positive metastatic breast cancer. The combined application of pertuzumab, trastuzumab and paclitaxel has been suggested as a standard therapy for HER2 positive advanced breast cancer. The resistance to anti-HER2 antibody has resulted in disease progression...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29209536/activating-her2-mutations-as-emerging-targets-in-multiple-solid-cancers
#17
REVIEW
Claire M Connell, Gary J Doherty
The epidermal growth factor receptor (EGFR) family of transmembrane receptor tyrosine kinases activates signalling pathways regulating cellular proliferation and survival. HER2 is a non-ligand-binding member of this family and exerts its activity through heterodimerisation with other EGFR family members. HER2 functional activation promotes oncogenesis, leading to the investigation of HER2-directed agents in cancers with HER2 alterations. This has been best characterised in the context of HER2 gene amplification in breast and gastro-oesophageal cancers, for which HER2-directed drugs form part of standard treatment regimens...
2017: ESMO Open
https://www.readbyqxmd.com/read/29209436/the-potential-relationship-between-flammer-and-sj%C3%A3-gren-syndromes-the-chime-of-dysfunction
#18
REVIEW
Babak Baban, Olga Golubnitschaja
Flammer syndrome (FS) is a term to blanket a cluster of vascular and nonvascular signs and symptoms linked to primary vascular dysregulation (PVD), increased sensitivity to various stimuli (stress, drugs, etc.) and altered sense regulation such as pain, smell and thirst perception. On one hand, disruption of blood barrier and homeostasis of the body are the main targets of vascular irregularity. Inflammation and immune disorders including autoimmunity are considered as a consequence of the abnormal vascular regulation processes...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29209143/risk-factors-and-preventions-of-breast-cancer
#19
REVIEW
Yi-Sheng Sun, Zhao Zhao, Zhang-Nv Yang, Fang Xu, Hang-Jing Lu, Zhi-Yong Zhu, Wen Shi, Jianmin Jiang, Ping-Ping Yao, Han-Ping Zhu
Breast cancer is the second leading cause of cancer deaths among women. The development of breast cancer is a multi-step process involving multiple cell types, and its prevention remains challenging in the world. Early diagnosis of breast cancer is one of the best approaches to prevent this disease. In some developed countries, the 5-year relative survival rate of breast cancer patients is above 80% due to early prevention. In the recent decade, great progress has been made in the understanding of breast cancer as well as in the development of preventative methods...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29208440/radiotherapy-in-the-setting-of-breast-reconstruction-types-techniques-and-timing
#20
REVIEW
Alice Y Ho, Zishuo I Hu, Babak J Mehrara, Edwin G Wilkins
As the use of breast reconstruction and postmastectomy radiotherapy (PMRT) has increased over the past decade, the typical approach to integrating radiotherapy with breast reconstruction has provoked intense controversy in the management of breast cancer. PMRT can lead to an increased frequency of complications in the reconstructed breast. Conversely, the reconstructed breast can increase the complexity of radiotherapy delivery. How to minimise the frequency of complications without compromising oncological or cosmetic outcomes of the reconstructed breast is an important shared multidisciplinary goal for oncologists and their patients...
December 2017: Lancet Oncology
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