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Jeroen Vangindertael, Rafael Camacho, Wouter Sempels, Hideaki Mizuno, Peter Dedecker, Kris Pieter Frans P F Janssen
Ever since the inception of light microscopy, the laws of physics have seemingly thwarted every attempt to visualize the processes of life at its most fundamental, sub- cellular, level. The diffraction limit has restricted our view to length scales well above 250 nm and in doing so, severely compromised our ability to gain true insights into many biological systems. Fortunately, continuous advancements in optics, electronics and mathematics have since provided the means to once again make physics work to our advantage...
February 9, 2018: Methods and Applications in Fluorescence
Joanna E Bettmann, David E Scheinfeld, Kort C Prince, Eric L Garland, Katherine V Ovrom
When veterans need effective mental health treatment, many are reluctant to engage in traditional treatment modalities because of stigma. Therapeutic adventure shows promise as a way to engage veterans and enact positive changes in functioning, but little is known about how therapeutic adventure impacts mental health symptoms among veterans. This study examined changes in mental health symptoms and related psychological processes over the course of a 6-day Outward Bound for Veterans (OB4V) program and at a 1-month follow-up...
February 8, 2018: Psychological Services
A Perciaccante, C Negri, A Coralli, P Charlier, O Appenzeller, R Bianucci
Niccolò Ugo Foscolo (1778-1827), known as Ugo, is one of the masters of the Italian poetry. A writer and a revolutionary, he embraced the ideals of the French Revolution and took part in the stormy political discussions, which the fall of the Republic of Venice had provoked. Despite his poor health, Foscolo lived an adventurous life serving as a volunteer in the Guardia Nazionale and in the Napoleonic army. Following Napoleon's fall (1814), he went into voluntary exile in early 1815. He reached London in Sept...
February 2018: Medical Hypotheses
Ian R Tofler, Brandon M Hyatt, David S Tofler
Extreme sports, defined as sporting or adventure activities involving a high degree of risk, have boomed since the 1990s. These types of sports attract men and women who can experience a life-affirming transcendence or "flow" as they participate in dangerous activities. Extreme sports also may attract people with a genetic predisposition for risk, risk-seeking personality traits, or underlying psychiatric disorders in which impulsivity and risk taking are integral to the underlying problem. In this report, we attempt to illustrate through case histories the motivations that lead people to repeatedly risk their lives and explore psychiatry's role in extreme sports...
2018: Permanente Journal
Nika Anžiček, Simon Williams, Michael P Housden, Ian Paterson
The aplyronines are a family of antimitotic marine macrolides that disrupt cytoskeletal dynamics by dual targeting of both actin and tubulin. Given their picomolar cytotoxicity profile and unprecedented mode of action, the aplyronines represent an excellent candidate as a novel payload for the development of next-generation antibody-drug conjugates (ADCs) for cancer chemotherapy. Enabled by an improved second-generation synthesis of the macrolactone core 5, we have achieved the first total synthesis of the most potent congener aplyronine D together with a highly stereocontrolled synthesis of aplyronine A...
February 2, 2018: Organic & Biomolecular Chemistry
Daniel Dominguez Ferraz, Karen Valadares Trippo, Gabriel Pereira Duarte, Mansueto Gomes Neto, Kionna Oliveira Bernardes Santos, Jamary Oliveira Filho
OBJECTIVES: To compare the effects of functional training, bicycle exercise and exergaming on walking capacity of elderly with Parkinson disease (PD). DESIGN: A pilot randomized controlled single-blinded trial. SETTING: A State Reference Health Care Centre for Elderly, a public reference outpatient clinic for the elderly. PARTICIPANTS: Sixty-two elderly individuals (≥60 years-old) with idiopathic PD (stage 2 to 3 of modified Hoehn and Yahr) according to the London Brain Bank...
January 11, 2018: Archives of Physical Medicine and Rehabilitation
Michael J Barry
No abstract text is available yet for this article.
January 16, 2018: Annals of Internal Medicine
Karina L R Canabrava, Fernanda R Faria, Jorge R P de Lima, Dartagnan P Guedes, Paulo R S Amorim
PURPOSE: This study aimed to compare the energy expenditure and intensity of active video games to that of treadmill walking in children and adolescents. METHOD: Seventy-two boys and girls (aged 8-13 years) were recruited from local public schools. Energy expenditure and heart rate were measured during rest, during 3-km/hr, 4-km/hr, and 5-km/hr walks, and during active games (Adventure, Boxing I, Boxing II, and Dance). During walking and active games, we also assessed physical activity using an accelerometer...
January 15, 2018: Research Quarterly for Exercise and Sport
Valeria Santini
No abstract text is available yet for this article.
January 10, 2018: Lancet Haematology
Janina Golob Deeb, Nicholas Walter, Caroline Carrico, Miha Gašperin, George R Deeb
INTRODUCTION: The popularity of adventure recreation in wilderness areas across the world continues to increase. Nevertheless, the risk of injury and illness remains significant. The purpose of this study is to analyze the mountain rescue operations performed in Slovenia between 2011 and 2015. METHODS: This retrospective study reports mountain rescue operations documented by the Slovenian National Mountain Rescue Association. The annual number of ground-based and helicopter-based rescues were identified and compared...
January 10, 2018: Wilderness & Environmental Medicine
(no author information available yet)
Having worked in the veterinary pharmaceutical industry, vet David Renney set up his own company to explore a niche area that involves bringing new or neglected ideas, products and technologies to the veterinary market.
January 6, 2018: Veterinary Record
Bin Yang, Melissa Vasbinder, Alexander W Hird, Qibin Su, Haixia Wang, Yan Yu, Dorin Toader, Paul D Lyne, Jon A Read, Jason Breed, Stephanos Ioannidis, Chun Deng, Michael Grondine, Nancy DeGrace, David Whitston, Patrick Brassil, James W Janetka
Checkpoint kinase-1 (CHK1) inhibitors are potential cancer therapeutics which can be utilized for enhancing the efficacy of DNA damaging agents. Multiple small molecule CHK1 inhibitors from different chemical scaffolds have been developed and evaluated in clinical trials in combination with chemotherapeutics and radiation treatment. Scaffold morphing of thiophene carboxamide ureas (TCUs), such as AZD7762 (1) and a related series of triazoloquinolines (TZQs), led to the identification of fused-ring bicyclic CHK1 inhibitors, 7-carboxamide thienopyridines (7-CTPs) and 7-carboxamide indoles...
January 4, 2018: Journal of Medicinal Chemistry
Claude B Sirlin
No abstract text is available yet for this article.
January 2018: Abdominal Radiology
Martin Weinhold, Edeltraud Mast-Gerlach, Vera Meyer
Filamentous fungi are fascinating microorganisms. One of the reasons why it is so worthwhile to take a closer look at them is their capacity to produce secondary metabolites. Some of these substances have the potential to be of great use for mankind, such as it was the case with penicillin and its discovery in 1928. Almost a century later, the situation in healthcare could possibly turn back to the state before the development of the first antibiotics. Due to an overuse of antibiotics we are facing a surge of multiresistant bacteria that are not inhibited by any of the currently known drugs...
2017: Fungal Biology and Biotechnology
Robert Fedele
British nurse Georgie Carroll moved to Australia seeking adventure and inadvertently discovered a hidden talent for making people laugh.
April 2017: Australian Nursing & Midwifery Journal
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2017: Primary Dental Journal
Daniel Bertrand, A V Terry
Nearly 30 years of experimental evidence supports the argument that ligands of nicotinic acetylcholine receptors (nAChRs) have potential as therapeutic agents. However, as in the famous Lewis Carroll novel "Alice in Wonderland", there have been many unexpected adventures along the pathway of development, and few nAChR ligands have been approved for any clinical condition to date with the exception of nicotine dependence. The recent failures of nAChR ligands in AD and schizophrenia clinical trials have reduced enthusiasm for this therapeutic strategy and many pharmaceutical companies have now abandoned this field of research...
December 14, 2017: Biochemical Pharmacology
Vicente Arroyo, Joan Clària
No abstract text is available yet for this article.
December 12, 2017: Clinical Gastroenterology and Hepatology
Yanqiu Song, Jialei Bai, Rong Zhang, Houluo He, Chao Li, Jiang Wang, Shuang Li, Yuan Peng, Baoan Ning, Minglin Wang, Zhixian Gao
The abuse of antibiotics results in a large number of antibiotics residues in the environment and even causes the problem of "super bacteria". Therefore, it is crucial to develop a powerful analytic method to monitor antibiotics quickly and simply. Photonic crystal (PC), as a sensing material, has a promising application prospects. Herein, we adventurously try to use PC to realize the pretreatment-free and label-free detection of Ciprofloxacin (CF) through Michael addition reaction. The recognition process is carried out by the Michael addition reaction between the piperazine group of CF and the o-benzoquinone group on the PC...
December 15, 2017: Analytical Chemistry
Christophe Soussan, Martin Andersson, Anette Kjellgren
BACKGROUND: The increasing number of legally ambiguous and precarious Novel Psychoactive Substances (NPS) constitutes a challenge for policy makers and public health. Scientific and more in-depth knowledge about the motivations for using NPS is scarce and often consist of predetermined, non-systematic, or poorly described reasons deduced from top-down approaches. Therefore, the aim of the present study was to explore and characterize the users' self-reported reasons for NPS use inductively and more comprehensively...
December 11, 2017: International Journal on Drug Policy
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