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https://www.readbyqxmd.com/read/28646406/podocytes-and-the-quest-for-precision-medicines-for-kidney-diseases
#1
REVIEW
Peter Mundel
In this review, I describe a 30-year journey in the quest for precision medicines for patients with kidney diseases. In 1987, when I started my reseach career, most scientists studying glomerular disease biology were focused on mesangial cells. The crucial role of the podocyte in many kidney diseases characterized by proteinuria, including focal segmental glomerulosclerosis (FSGS) and diabetic nephropathy, had not yet been recognized. We were not aware of genetic causes or drivers of kidney diseases nor of molecular markers and cell culture systems for mechanistic studies of podocyte biology...
June 23, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28641326/a-technical-diving-related-burns-case-treatment-in-a-remote-location
#2
Fiona C Sharp, Martin Dj Sayer
Injuries suffered as a result of a rebreather oxygen explosion and fire occurred to a diver on vacation in the island state of Chuuk, Micronesia. The medical and logistical management of the diver in a remote location are described. The mechanism of both the fire and the subsequent blast and burn injuries are discussed. Prevention of and preparation for such incidents are discussed in the context of the increasing frequency of dive and adventure travel to remote areas.
June 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/28639111/a-lifetime-s-adventure-in-extracellular-k-regulation-the-scottish-connection
#3
Angus M Brown
In a career that has spanned 45 years and shows no signs of slowing down, Dr Bruce Ransom has devoted considerable time and energy to studying regulation of interstitial K(+). When Bruce commenced his studies in 1969 virtually nothing was known of the functions of glial cells, but Bruce's research contributed to the physiological assignation of function to mammalian astrocytes, namely interstitial K(+) buffering. The experiments that I describe in this review concern the response of the membrane potential (Em) of in vivo cat cortical astrocytes to changes in [K(+)]o, an experimental manoeuvre that was achieved in two different ways...
June 21, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28608356/-the-influence-of-spanish-neuropsychiatry-on-the-improbable-medicine-of-ramon-gomez-de-la-serna
#4
REVIEW
G Delgado-Garcia, C Rodriguez-Navarez, T Corona, B Estanol-Vidal
INTRODUCTION: El doctor inverosimil (The Improbable Doctor) is a novel by Ramon Gomez de la Serna (1888-1963) in which the reader follows, by means of a series of different clinical cases, the adventures of Doctor Vivar. AIMS: To present and discuss, for the first time, the influence that Spanish neuropsychiatry had on this novel, taking the following short stories as study models: 'Casos cerebrales' ('Brain Cases') and 'La risita' ('The Giggles'). DEVELOPMENT: In these two tales, the improbable doctor embodies the three defining elements of Spanish neuropsychiatry...
June 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28604118/practical-tips-for-working-as-an-expedition-doctor-on-high-altitude-expeditions
#5
Anne Brants, Tracee Metcalfe
Brants, Anne, and Tracee Metcalfe. Practical tips for working as an expedition doctor on high-altitude expeditions. High Alt Med Biol 00:000-000, 2017.-With the explosion of adventure travel over the past decade, there has been a concurrent increase in mountaineering expeditions to extreme elevations, including many of the 8000-m peaks. This trend has created an increased demand for qualified expedition doctors to provide specialized medical advice and care to climbers and expedition staff. This review is intended to help physicians prepare for work on such expeditions...
June 12, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28599976/the-adventurous-way-from-feasibility-to-advisability
#6
EDITORIAL
Tine Philipsen, Thierry Bove
No abstract text is available yet for this article.
May 18, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28579910/influence-of-biological-experiential-and-psychological-factors-in-wine-preference-segmentation
#7
Gary J Pickering, John E Hayes
BACKGROUND AND AIMS: We sought to determine the influence of selected biological, experiential and psychological variables on self-reported liking and consumption of wine in a sample of 329 Ontario wine consumers. METHODS AND RESULTS: Cluster analysis revealed three distinct groups, representing plausible market segments: wine lovers; dry table wine likers/sweet dislikers; and sweet wine likers/fortified dislikers. These groups differ in level of wine expertise, wine adventurousness, alcohol intake, bitterness from 6-n-propylthiouracil (PROP), and several demographic variables...
June 2017: Australian Journal of Grape and Wine Research
https://www.readbyqxmd.com/read/28578008/an-adventure-with-don
#8
Richard Henderson
No abstract text is available yet for this article.
May 31, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28566803/greater-muscle-damage-in-athletes-with-actn3-r577x-rs1815739-gene-polymorphism-after-an-ultra-endurance-race-a-pilot-study
#9
T Belli, A H Crisp, R Verlengia
In this study, we aimed to investigate the influence of ACTN3 R577X gene polymorphism on muscle damage responses in athletes competing in an ultra-endurance race. Twenty moderate to well-trained ultra-runners who had entered in an official 37.1 km adventure race (22.1 km mountain biking, 10.9 km trekking, 4.1 km water trekking, 30 m rope course, and orienteering) volunteered for the study. Blood samples were collected for genotyping and analysis of muscle protein levels before and after the race. Percentage changes (pre- to post-race) of serum myoglobin [XX = 5,377% vs...
June 2017: Biology of Sport
https://www.readbyqxmd.com/read/28557779/adventures-in-the-environmental-world-and-environmental-microbiology-sampling-of-air-for-pharmaceutical-sterile-compounding
#10
Roberto Ligugnana
Chapter <797> issued by the United States Pharmacopeial Convention, Inc. is the standard for sterile compounding. It is designed to reduce the number of patient infections due to contaminated pharmaceutical preparation. This regulation applies to all staff who prepare compounded sterile preparations and all places where they are produced, including hospitals, clinics, pharmacies, and physician's offices. This article provides the history of environmental microbiology and provides a discussion on environmental microbiology sampling of air for pharmaceutical sterile compounding...
May 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28555018/adventure-behavior-seeking-scale
#11
Piotr Próchniak
This article presents a new tool-the Adventure Behavior Seeking Scale (ABSS). The Adventure Behavior Seeking Scale was developed to assess individuals' highly stimulating behaviors in natural environments. An exploratory factor analysis was conducted with 466 participants and resulted in one factor. The internal consistency was 0.80. A confirmatory factor analysis was performed using another sample of 406 participants, and results verified the one-factor structure. The findings indicate that people with a lot of experience in outdoor adventure have a higher score on the ABSS scale than control groups without such experience...
May 27, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28511956/erosion-of-the-duodenum-by-an-aortic-graft-leading-to-recurrent-sepsis
#12
Ege Altan, Nomingerel Tseveldorj, Taylan Kav
No abstract text is available yet for this article.
May 13, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28495987/a-multidisciplinary-and-multicultural-adventure-from-materials-engineering-to-cardiovascular-science
#13
Vahid Serpooshan
No abstract text is available yet for this article.
May 12, 2017: Circulation Research
https://www.readbyqxmd.com/read/28488406/between-a-rock-and-a-hard-place-adventures-in-treating-calcific-femoropopliteal-disease
#14
EDITORIAL
Richard Heuser
SFA disease has unique challenges A myriad of interventional techniques have been proposed to treat calcific femoral disease It appears a combination of atherectomy and drug elution may be the procedure of choice in these patients New innovative therapies may be a viable option in the future.
May 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28480387/politics-of-biopiracy-an-adventure-into-hoodia-xhoba-patenting-in-southern-africa
#15
Lere Amusan
BACKGROUND: Africa is being described as the wretched of the earth, despite this, the continent is endowed with natural resources, dynamic ecosystem, and different species of plants and animals, and species derivatives. This paper area of departure is to focus on Hoodia, a plant that is being a source of food, medicine and water for the San and Khoe indigenous peoples before the advent of Europeans into southern Africa. South African Council for Scientific and Industrial Research (CSIR) dubiously patented Hoodia without observing the basic indices of geographical indications (GIs), indigenous knowledge (IK), novelty, access sharing benefit (ASB), prior informed consent (PIC) and sustainability of ecosystem before the rights was sold to Phytopharm pharmaceutical company...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28470176/dyslipidaemia-the-pcsk9-adventure-humanizing-extreme-ldl-lowering
#16
Michael D Shapiro, Sergio Fazio
No abstract text is available yet for this article.
June 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28456629/mitochondrial-adventures-at-the-organelle-society
#17
Cátia V Diogo, King Faisal Yambire, Lorena Fernández Mosquera, Tiago Branco F, Nuno Raimundo
Mitochondria are constantly communicating with the rest of the cell. Defects in mitochondria underlie severe pathologies, whose mechanisms remain poorly understood. It is becoming increasingly evident that mitochondrial malfunction resonates in other organelles, perturbing their function and their biogenesis. In this manuscript, we review the current knowledge on the cross-talk between mitochondria and other organelles, particularly lysosomes, peroxisomes and the endoplasmic reticulum. Several organelle interactions are mediated by transcriptional programs, and other signaling mechanisms are likely mediating organelle dysfunction downstream of mitochondrial impairments...
April 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28447331/understanding-action-and-adventure-sports-participation-an-ecological-dynamics-perspective
#18
Tuomas Immonen, Eric Brymer, Dominic Orth, Keith Davids, Francesco Feletti, Jarmo Liukkonen, Timo Jaakkola
Previous research has considered action and adventure sports using a variety of associated terms and definitions which has led to confusing discourse and contradictory research findings. Traditional narratives have typically considered participation exclusively as the pastime of young people with abnormal characteristics or personalities having unhealthy and pathological tendencies to take risks because of the need for thrill, excitement or an adrenaline 'rush'. Conversely, recent research has linked even the most extreme forms of action and adventure sports to positive physical and psychological health and well-being outcomes...
December 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28435759/md-5-big-island-adventures-the-challenges-and-rewards-of-rural-physician-practices
#19
Quinn Ng
No abstract text is available yet for this article.
March 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28411937/preparing-for-international-travel-and-global-medical-care
#20
REVIEW
Swaminatha V Mahadevan, Matthew C Strehlow
Thorough pretravel preparation and medical consultation can mitigate avoidable health and safety risks. A comprehensive pretravel medical consultation should include an individualized risk assessment, immunization review, and discussion of arthropod protective measures, malaria prophylaxis, traveler's diarrhea, and injury prevention. Travel with children and jet lag reduction require additional planning and prevention strategies; travel and evacuation insurance may prove essential when traveling to less resourced countries...
May 2017: Emergency Medicine Clinics of North America
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