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Deepika Jaiswal, Rashi Turniansky, Erin M Green
When yeast cells are challenged by a fluctuating environment, signaling networks activate differentiation programs that promote their individual or collective survival. These programs include the initiation of meiotic sporulation, the formation of filamentous growth structures, and the activation of programmed cell death pathways. The establishment and maintenance of these distinct cell fates are driven by massive gene expression programs that promote the necessary changes in morphology and physiology. While these genomic reprogramming events depend on a specialized network of transcription factors, a diverse set of chromatin regulators, including histone-modifying enzymes, chromatin remodelers, and histone variants, also play essential roles...
October 18, 2016: Journal of Molecular Biology
Waltraud Maierhofer, Emanuella Israel
The Fifty Shades trilogy by E.L. James has taken the world by storm and become a cultural phenomenon. The lack of contraceptive use in the erotic fiction, first pointed out by bloggers, is analysed in this article and compared to medical information. James may be praised for sexualising condom use. However, her protagonist makes poor choices in terms of hormonal contraception and is negligent about its use, resulting in an unintended pregnancy and resolved in marital bliss and motherhood. What is of more interest here than a possible message about contraceptive use, is the outcome that the fiction's negligence in birth control and responsibility affirms an ideology in which female sexuality and sexual experimentation can only be tolerated within the context of procreation and affirmation of motherhood...
October 20, 2016: Culture, Health & Sexuality
Courtney E Sutherland, Toban Dvoretzky, Nicholas J Solomos
Wedgies-the upward yanking of another's underpants from the rear to wedge them between the buttocks-can be administered playfully, maliciously, or adventurously; at forces ranging from gentle to "atomic"; and with or without the foreknowledge or consent of the recipient. Wedgies have been documented anecdotally in the popular Internet literature, with chief emphasis on their sensation-seeking or momentary entertainment value to the giver and recipient. Most participants are typically young; however, we report the case of a 50-year-old man who sustained chronic, painless radiculitis after he received an unanticipated wedgie of moderate force...
October 2016: Proceedings of the Baylor University Medical Center
Jess French
During her first degree, Jess French founded a programme in which university students taught primary school children about environmental issues. She recently qualified as a vet and, when not studying, teaching, writing or looking for bugs, she enjoys adventure sports and travel, learning new languages and playing the saxophone and drums. She is also a presenter on CBeebies.
October 1, 2016: Veterinary Record
(no author information available yet)
If you are undertaking a research module or degree requiring statistics, then this text book will be a valuable addition to your library.
September 28, 2016: Nursing Standard
Damian Scarf, Jillian G Hayhurst, Benjamin C Riordan, Mike Boyes, Ted Ruffman, John A Hunter
OBJECTIVE: Mental health problems are a leading cause of health-related disability during adolescence. The objectives of the current study were to investigate whether participating in an adventure education programme (AEP) increased adolescents' resilience and elucidate how social connectedness contributes to any increase. METHOD: Adolescents who participated in the AEP had their resilience measured on the first (Time 1) and last day (Time 2) of a 10-day voyage...
September 27, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Gilbert Umaye Adie, Lingyu Sun, Xianlai Zeng, Lixia Zheng, Oladele Osibanjo, Jinhui Li
Management of waste electrical and electronic equipment (WEEE) has recently attracted worldwide attention because of high metal concentrations in them. Evolution of toxic and precious metals utilized in WEEE can not only reflect the adventure of eco-design, but can also guide the final recycling option. Pb, As, Cu, Au, Sn and Ag were determined in 10 composite samples of printed circuit boards of cathode ray tube televisions (TV-PCBs) that were produced between 1980 and 2005. The obtained results indicated that average metal concentrations in all TV-PCBs were - Cu: 10...
October 2, 2016: Environmental Technology
Janneke Caw Peijnenborgh, Petra Pm Hurks, Albert P Aldenkamp, Erik D van der Spek, Gwm Rauterberg, Johan Sh Vles, Jos Gm Hendriksen
BACKGROUND: A computer-based game, named Timo's Adventure, was developed to assess specific cognitive functions (eg, attention, planning, and working memory), time perception, and reward mechanisms in young school-aged children. The game consists of 6 mini-games embedded in a story line and includes fantasy elements to enhance motivation. OBJECTIVE: The aim of this study was to investigate the validity of Timo's Adventure in normally developing children and in children with attention-deficit/hyperactivity disorder (ADHD)...
2016: JMIR Serious Games
Kunihiko Suzuki
In this hybrid of a personal essay and a subjective review, I am attempting to convey the sense of an adventure I myself experienced in exploring various aspects of Krabbe disease, which occupied a significant portion of my life as a biomedical researcher. This is meant to be a personal summary, and I have no pretense of this being an objective scholarly review. Since the first description of the disease by Krabbe 100 years ago, knowledge about the disease has advanced significantly. The main contributions from my laboratory, always the fruits of dedicated efforts of talented young colleagues, include the identification of the genetic defect as deficiency of galactosylceramidase, proposal of the psychosine hypothesis as the pathogenetic mechanism to explain the unique phenotypic characteristics of the disease, detailed delineations of the substrate specificities of the two lysosomal β-galactosidases, discovery of the twitcher mutant as a convenient and useful mouse model, and identification of saposin A as a specific galactosylceramide activator protein and as the second causative gene for globoid cell leukodystrophy...
November 2016: Journal of Neuroscience Research
Phuong Minh Pham
Schultz RC. Morgan Hill, California: Bookstand Publishing. ISBN: 1618635549. Pp. 243. 87 illustrations. Softcover. 2013. $15.95.
September 12, 2016: Cleft Palate-craniofacial Journal
Angela Ting
Extract: Halfway through my third year in college, I still had not decided on a career path. I toyed with the idea of going to law school to become an intellectual property lawyer. I considered further training to become a genetic counselor. I also attended several career opportunity seminars by notable consulting firms. None of these possibilities really excited me. Coincidentally, I had started attending a superb journal club led by Dr. Carl Douglas at the University of British Columbia. By far, it was one of the most enjoyable classes I had taken because we were reading and discussing research studies that were pushing the frontiers of knowledge...
September 7, 2016: Endocrine-related Cancer
Douglas C Wu, Mitchel P Goldman
No abstract text is available yet for this article.
September 2, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Daniel Bradshaw, Jayna Raghwani, Brendan Jacka, Rachel Sacks-Davis, Francois Lamoury, Ian Down, Garrett Prestage, Tanya L Applegate, Margaret Hellard, Joe Sasadeusz, Gregory J Dore, Oliver G Pybus, Gail V Matthews, Mark Danta
BACKGROUND: This study aimed to investigate the potential influence of venue-based networks on HCV transmission in HIV-positive gay and bisexual men (GBM). METHODS: This was a prospectively recruited cohort of HIV-infected GBM with recently-acquired HCV infection resident in Melbourne and Sydney. Clinical and demographic data were collected together with blood samples for HCV sequencing. Phylogenies were inferred and clusters of individuals infected with HCV with genetic sequence homology were identified...
2016: PloS One
Jina Huh, Bum Chul Kwon, Sung-Hee Kim, Sukwon Lee, Jaegul Choo, Jihoon Kim, Min-Je Choi, Ji Soo Yi
Many researchers and practitioners use online health communities (OHCs) to influence health behavior and provide patients with social support. One of the biggest challenges in this approach, however, is the rate of attrition. OHCs face similar problems as other social media platforms where user migration happens unless tailored content and appropriate socialization is supported. To provide tailored support for each OHC user, we developed personas in OHCs illustrating users' needs and requirements in OHC use...
August 26, 2016: Journal of Biomedical Informatics
Ralf C Buckley
People can speak, and this provides opportunities to analyze human emotions using perceived experiences communicated via language, as well as through measurement and imaging techniques that are also applicable to other higher animal species. Here I compare four qualitative methodological approaches to test if, and how, thrill depends on fear. I use eight high-risk, high-skill, real-life outdoor adventure recreation activities to provide the test circumstances. I present data from: >4000 person-days of participant observation; interviews with 40 expert practitioners; retrospective autoethnography of 50 critical incidents over 4 decades; and experimental autoethnography of 60 events...
2016: Frontiers in Psychology
Tracey Ledoux, Melissa Griffith, Debbe Thompson, Nga Nguyen, Kathy Watson, Janice Baranowski, Richard Buday, Dina Abdelsamad, Tom Baranowski
BACKGROUND: Playing Escape from DIAB (DIAB) and Nanoswarm (NANO), epic video game adventures, increased fruit and vegetable consumption among a multi-ethnic sample of 10-12 year old children during pilot testing. Key elements of both games were educational mini-games embedded in the overall game that promoted knowledge acquisition regarding diet, physical activity and energy balance. 95-100% of participants demonstrated mastery of these mini-games suggesting knowledge acquisition. AIM: This article describes the process of designing and developing the educational mini-games...
August 2016: Simulation & Gaming
Mauro Sasdelli
In Italy, Nephrology and Dialysis born in the 50s. Among the protagonists of those years, there were Vittorio Bonomini and Pietro Zucchelli. In Bologna, they created a school of nephrology of national and international importance that generated many distinguished pupils. In the 60-70s, the author joined the school as student, then as assistant. He describes university life at the time of one of the last barons, Domenico Campanacci. Moreover, it is illustrated the adventurous birth and development of hemodialysis and peritoneal dialysis, under the guidance of Bonomini and Zucchelli...
July 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
P Weatherburn, F Hickson, D Reid, S Torres-Rueda, A Bourne
OBJECTIVES: There is considerable public health concern about the combining of sex and illicit drugs (chemsex) among gay men. With a view to inform supportive therapeutic and clinical interventions, we sought to examine the motivations for engaging in chemsex among gay men living in South London. METHODS: Community advertising recruited 30 gay men for qualitative semi-structured interview. Aged between 21 and 53 years, all lived in South London in the boroughs of Lambeth, Southwark and Lewisham and all had combined crystal methamphetamine, mephedrone and/or γ-hydroxybutyric acid/γ-butyrolactone with sex in the past 12 months...
August 12, 2016: Sexually Transmitted Infections
M Schneider
"The objective of Pitfall!™ is to guide Harry through a maze of jungle scenes, jumping over or avoiding many deadly dangers… Harry has three lives in each game." If you exchange Harry's adventures with "Life with SLE," patients have to be guided through the jungle having just one life and the deadly dangers are flares, organ manifestations, and, e.g., consequences of immunosuppressive medications, especially glucocorticoids. Monitoring and treatment in line with recommendations and guidelines may be supportive to survive the first 3 to 5 levels in most cases, but for higher levels of the reality game, creativity is needed and life becomes more risky...
August 2, 2016: Autoimmunity Reviews
A D C Macknight
No abstract text is available yet for this article.
September 2016: Advances in Physiology Education
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