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https://www.readbyqxmd.com/read/29909639/adventures-in-atropisomerism-total-synthesis-of-a-complex-active-pharmaceutical-ingredient-with-two-chirality-axes
#1
Gregory Beutner, Ronald Carrasquillo, Peng Geng, Yi Hsiao, Eric C Huang, Jacob Janey, Kishta Katipally, Sergei Kolotuchin, Thomas La Porte, Andrew Lee, Paul Lobben, Federico Lora-Gonzalez, Brendan Mack, Boguslaw Mudryk, Yuping Qiu, Xinhua Qian, Antonio Ramirez, Thomas M Razler, Thorsten Rosner, Zhongping Shi, Eric Simmons, Jason Stevens, Jianji Wang, Carolyn Wei, Steven R Wisniewski, Ye Zhu
A strategy to prepare compounds with multiple chirality axes, which has led to a concise total synthesis of compound 1A with complete stereocontrol, is reported.
June 17, 2018: Organic Letters
https://www.readbyqxmd.com/read/29886335/decreased-retention-of-olfactory-predator-recognition-in-juvenile-surgeon-fish-exposed-to-pesticide
#2
Frédéric Bertucci, Hugo Jacob, Alexandre Mignucci, Camille Gache, Natacha Roux, Marc Besson, Cécile Berthe, Marc Metian, David Lecchini
Dory, the animated surgeonfish created by the Pixar Animation studios, famously suffered from short-term memory loss leading to many adventures. In reality, many fishes have excellent cognitive abilities and are able to learn and retain important information such as the identity of predators. However, if and how cognition can be affected by anthropogenically altered oceanic conditions is poorly understood. Here, we examine the effect of a widely used pesticide, chlorpyrifos, on the retention of acquired predator recognition in post-larval stage of the surgeonfish Acanthurus triostegus...
June 4, 2018: Chemosphere
https://www.readbyqxmd.com/read/29868991/traditional-sex-and-gender-stereotypes-in-the-relationships-of-non-disclosing-behaviorally-bisexual-men
#3
Karolynn Siegel, Étienne Meunier
Traditional stereotypes about sex and gender present men as assertive, aggressive, sexually adventurous, and emotionally restrained, and women as docile, passive, sexually modest, and emotionally sensitive. Past research has shown that such stereotypes impose constraints on heterosexual relationships that decrease sexual satisfaction for men and women. This study examined the impact of traditional sex and gender stereotypes on a sample of 203 behaviorally bisexual men who were in a heterosexual relationship with a woman to whom they did not disclose their same-sex behaviors...
June 4, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29868173/adventure-tourism-and-schistosomiasis-serology-and-clinical-findings-in-a-group-of-danish-students-after-white-water-rafting-in-uganda
#4
Dennis Röser, Stephanie Bjerrum, Marie Helleberg, Henrik Vedel Nielsen, Kim Peter David, Søren Thybo, Christen Rune Stensvold
Introduction: Diagnosis of schistosomiasis in travellers is a clinical challenge, since cases may present with no symptoms or a few non-specific symptoms. Here, we report on the laboratory and clinical findings in Danish travellers exposed to Schistosoma -infested water during white-water rafting on the Ugandan part of the upper Nile River in July 2009. Case presentation: Forty travellers were offered screening for Schistosoma -specific antibodies. Serological tests were performed 6-65 weeks after exposure...
April 2018: JMM Case Reports
https://www.readbyqxmd.com/read/29863757/platinum-in-chemistry-an-adventure-from-phosphorescent-materials-to-catalytic-c-h-functionalization
#5
REVIEW
Shouquan Huo
Platinum is a precious and versatile metal and has played important roles in various fields of chemistry ranging from functional materials to anticancer drugs and catalysis. This account highlights an adventurous journey of platinum from promoting phosphorescence to catalyzing a C-H functionalization reaction, or you may consider it our research adventure from phosphorescent materials to catalysis. Interestingly, this journey is driven by a series of "bad" reactions, and of course more importantly by our curiosity about the "bad" reactions...
June 4, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29849201/the-intrepid-adventure-of-early-transcatheter-mitral-valve-replacement
#6
EDITORIAL
Qasim Stanazai, Mohamad Alkhouli
No abstract text is available yet for this article.
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29789961/illnesses-associated-with-freshwater-recreation-during-international-travel
#7
REVIEW
Daniel L Bourque, Joseph M Vinetz
PURPOSE OF REVIEW: International travel, adventure travel, and eco-tourism are increasing over the past few decades. This review aims to summarize the spectrum of infections associated with recreational freshwater activities and international travel. RECENT FINDINGS: Recreational water activities can be associated with a wide range of infections. Acute febrile illnesses due to leptospirosis and schistosomiasis are not uncommon in travelers following extensive freshwater exposure...
May 22, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29788160/mind-the-eye-squirter-an-anthia-sexmaculata-sexmaculata-related-necrotic-burn
#8
Olivier Aoun, Mickaël François, Jean-Paul Demoncheaux, Christophe Rapp
We report the case of an Anthia sexmaculata sexmaculata-associated necrotic burn in a French expatriate in Mauritania. Anthia spp.-related injury is a common though underreported health issue in the Sahelo-Saharan area. Deployed soldiers and travellers should be aware of these beetles when adventuring in this region.
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29764633/national-preceptor-development-program-pdp-prototype-the-third-of-a-3-part-series
#9
Craig D Cox, Katrina Mulherin, Sheila Walter
INTRODUCTION: Preceptor development is critical to successful delivery of experiential learning. Although many preceptor development programs exist, a more individualized approach to training is needed. To accomplish this a national preceptor development program should be considered based on the continuing professional development model. A detailed prototype for this program has been described. METHODS: In this final installment of the series, the twelve evidence-based recommendations from the first installment were utilized to construct a prototype for a preceptor development program...
March 2018: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29752846/it-s-like-balancing-on-a-slackline-a-description-of-how-adults-with-congenital-heart-disease-describe-themselves-in-relation-to-physical-activity
#10
Annika Bay, Kristina Lämås, Malin Berghammer, Camilla Sandberg, Bengt Johansson
AIMS AND OBJECTIVES: To illuminate how adults with CHD describe themselves in relation to physical activity. BACKGROUND: Several studies have shown that adults with congenital heart disease (CHD) have reduced exercise capacity and do not reach the recommended daily level of physical activity. With this in view, it is of immense importance to investigate how this population experiences physical activity. DESIGN: Qualitative study with semi-structured interviews analysed with qualitative content analysis...
May 12, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29705449/of-dodo-birds-and-common-factors-a-scoping-review-of-direct-comparison-trials-in-adventure-therapy
#11
Will W Dobud, Nevin J Harper
BACKGROUND: Adventure therapy (AT) is a term that includes therapies such as wilderness therapy and adventure-based counseling. With growing empirical support for AT, the diversity of studies make it difficult to attribute outcomes to specific treatment factors. OBJECTIVES: Researchers explored whether AT, often perceived as an alternative therapy, works because of AT's unique components, or whether factors shared by all therapies were responsible. METHODS: A scoping review was undertaken utilizing a search of major databases, unpublished dissertations, and a hand search for direct comparison trials matching AT with another therapeutic intervention...
May 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29701325/pediatric-maxillofacial-trauma-epidemiologic-study-between-the-years-2012-and-2015-in-an-israeli-medical-center
#12
Michael Joachim, Moti Tuizer, Shareef Araidy, Imad Abu El-Naaj
BACKGROUND/AIM: Trauma is the leading cause of morbidity and mortality in the pediatric population worldwide, and Israel is no different in this aspect. Of these injuries, craniofacial trauma is a significant cause of morbidity in the pediatric population. The high occurrence of pediatric trauma is possibly related to a lower perception for the hazards that surround them, combined with the restless and adventurous nature that is typical of children. The aim was to perform a retrospective, epidemiological study on facial trauma in children examined in the emergency room in order to analyze the different patterns in pediatric maxillofacial trauma, to emphasize this data and educate those involved in preventing and treating children's injuries...
April 27, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/29695661/enhanced-delignification-of-lignocellulosic-substrates-by-pichia-gs115-expressed-recombinant-laccase
#13
Vidya Pradeep Kumar, Atul P Kolte, Arindam Dhali, Chandrashekar Naik, Manpal Sridhar
Utilization of energy-rich crop residues by ruminants is restricted by the presence of lignin, which is recalcitrant to digestion. Application of lignin degrading enzymes on the lignocellulosic biomass exposes the cellulose for easy digestion by ruminants. Laccases have been found to be considerably effective in improving the digestibility by way of delignification. However, laccase yields from natural hosts are not sufficient for industrial scale applications, which restricts their use. A viable option would be to express the laccase gene in compatible hosts to achieve higher production yields...
April 25, 2018: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/29689482/adventure-based-training-to-promote-physical-activity-and-reduce-fatigue-among-childhood-cancer-survivors-a-randomized-controlled-trial
#14
William H C Li, K Y Ho, K K W Lam, H S Lam, S Y Chui, Godfrey C F Chan, A T Cheung, L L K Ho, O K Chung
BACKGROUND: Cancer-related fatigue is one of the most distressing symptoms reported by childhood cancer survivors. Despite the body of evidence that regular physical activity helps alleviate cancer-related fatigue, insufficient participation in physical activity is frequently observed among childhood cancer survivors. OBJECTIVES: This study examined the effectiveness of an adventure-based training programme in promoting physical activity, reducing fatigue, and enhancing self-efficacy and quality of life among Hong Kong Chinese childhood cancer survivors...
July 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29665560/are-online-poker-problem-gamblers-sensation-seekers
#15
Céline Bonnaire, Servane Barrault
The purpose of this research was to examine the relationship between sensation seeking and online poker gambling in a community sample of adult online poker players, when controlling for age, gender, anxiety and depression. In total, 288 online poker gamblers were recruited. Sociodemographic data, gambling behavior (CPGI), sensation seeking (SSS), depression and anxiety (HADS) were evaluated. Problem online poker gamblers have higher sensation seeking scores (total, thrill and adventure, disinhibition and boredom susceptibility subscores) and depression scores than non-problem online poker gamblers...
June 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29621619/adventures-with-rna-graphs
#16
REVIEW
Tamar Schlick
The structure of RNA has been a natural subject for mathematical modeling, inviting many innovative computational frameworks. This single-stranded polynucleotide chain can fold upon itself in numerous ways to form hydrogen-bonded segments, imperfect with single-stranded loops. Illustrating these paired and non-paired interaction networks, known as RNA's secondary (2D) structure, using mathematical graph objects has been illuminating for RNA structure analysis. Building upon such seminal work from the 1970s and 1980s, graph models are now used to study not only RNA structure but also describe RNA's recurring modular units, sample the conformational space accessible to RNAs, predict RNA's three-dimensional folds, and apply the combined aspects to novel RNA design...
April 3, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29605540/the-management-of-methamphetamine-use-in-sexual-settings-among-men-who-have-sex-with-men-in-malaysia
#17
Sin How Lim, Mohd Akbar, Jeffrey A Wickersham, Adeeba Kamarulzaman, Frederick L Altice
BACKGROUND: The intentional use of illicit drugs for sexual purposes (also known as 'chemsex') is well known within the MSM communities in Malaysia although research in this population is scarce primarily because both drug use and homosexuality are illegal and stigmatised in Malaysia. METHODS: From April to December 2014, interviews were conducted with twenty men (age range 21-43) living in Greater Kuala Lumpur who had sexual intercourse with other men in the past 6 months and who used illicit drugs at least monthly in the past 3 months...
May 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29593744/studies-of-mast-cells-adventures-in-serendipity
#18
REVIEW
Melissa A Brown
Like many of us who had the great fortune to work with Bill Paul, my science life was immeasurably altered by my interactions with him. Although intimidating at first because of his stature in the immunology world, it was soon clear that he not only truly cared about the specific research we were doing together, but he wished to convey to his trainees an approach to science that was open, always questioning, and infinitely fun. His enthusiasm was infectious and after my training with him, despite stresses due to funding and publishing hurdles, I never regretted the path I took...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29546966/a-nurse-researcher-s-guide-to-reflexive-interviewing
#19
Holly Lear, Winifred Eboh, Lesley Diack
BACKGROUND: In a wider doctoral study related to unfavourable experiences of nursing students studying abroad, the researcher undertook a reflexive interview to reduce the potential for bias. AIM: To discuss a method for conducting reflexive interviews and recommend their use to nurse researchers. DISCUSSION: A reflexive interview was undertaken to reduce bias and pilot an original interview instrument. A senior researcher interviewed the researcher using original questions that would be used to interview participants in the wider doctoral study...
March 16, 2018: Nurse Researcher
https://www.readbyqxmd.com/read/29541044/aging-adventure-athletes-assess-achievements-and-alter-aspirations-to-maintain-self-esteem
#20
Ralf C Buckley
Achievements and capabilities influence the self-esteem of skilled adventure athletes. Self-esteem affects individual mental health. Aging commonly reduces adventure capabilities. To avoid loss in self-esteem, aging adventure athletes are forced to adjust their aspirations. Here, I examine this process using participant observation, ethnographic and autoethnographic approaches. The qualitative data for this analysis are derived from 60 years' experience in outdoor adventure activities, and ∼30,000 person-hours of participant observation...
2018: Frontiers in Psychology
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