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Hepatitis C virus

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https://www.readbyqxmd.com/read/29334550/chronic-hepatitis-c-virus-infection-and-subsequent-hiv-viral-load-among-women-with-hiv-initiating-antiretroviral-therapy
#1
Sarah J Willis, Stephen R Cole, Daniel Westreich, Andrew Edmonds, Christopher B Hurt, Svenja Albrecht, Kathryn Anastos, Michael Augenbraun, Margaret Fischl, Audrey L French, Aley G Kalapila, Roksana Karim, Marion G Peters, Michael Plankey, Eric C Seaberg, Phyllis C Tien, Adaora A Adimora
OBJECTIVE(S): One in four persons living with HIV is coinfected with HCV. Biological and behavioral mechanisms may increase HIV viral load among coinfected persons. Therefore, we estimated the longitudinal effect of chronic HCV on HIV suppression after ART initiation among women with HIV (WWH). DESIGN: HIV RNA was measured every six months among 441 WWH in the Women's Interagency HIV Study who initiated ART from 2000-2015. METHODS: Log-binomial regression models were used to compare the proportion of study visits with detectable HIV RNA between women with and without chronic HCV...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29334502/risk-of-hepatitis-b-virus-reactivation-among-patients-treated-with-ledipasvir-sofosbuvir-for-hepatitis-c-virus-infection
#2
Beshoy T Yanny, Nyan L Latt, Sammy Saab, Steven Han, Gina Choi, Jason Kramer, Amandeep K Sahota
BACKGROUND: Direct acting antiviral (DAA) agents are the standard of care for treatment of hepatitis C virus (HCV)-infected individuals. Hepatitis B virus (HBV) reactivation during HCV treatment has been reported, the incidence and clinical outcome remains unclear. The aim of our study is to examine the risk of HBV reactivation in actively infected or previously exposed patients during or after HCV treatment with DAAs. METHODS: Adults with chronic HCV infection previously exposed or actively infected with HBV and treated with DAAs between December 2015 to 2016 were included...
January 12, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29333940/expression-analysis-of-liver-specific-circulating-micrornas-in-hcv-induced-hepatocellular-carcinoma-in-egyptian-patients
#3
Lobna Mourad, Eman El-Ahwany, Mona Zoheiry, Hoda Abu-Taleb, Marwa Hassan, Amged Ouf, Ali Abdel Rahim, Moataz Hassan, Suher Zada
OBJECTIVES: Due to the absence of reliable and accurate biomarkers for the early detection of liver malignancy, circulating microRNAs have recently emerged as great candidates for prompt cancer identification. Therefore, the aim of this study was to investigate the potential of liver-specific circulating microRNAs as an accurate non-invasive diagnostic tool for early diagnosis of hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC). METHODOLOGY: A total of 165 patients were enrolled in this study and categorized into four main groups: 42 chronic hepatitis C (CHC) without cirrhosis, 45 CHC with cirrhosis (LC), 38 HCC with HCV patients, and 40 healthy controls...
January 15, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29333065/hepatitis-c-infection-in-patients-with-hereditary-bleeding-disorders-epidemiology-natural-history-and-management
#4
REVIEW
Nikolaos Papadopoulos, Vasiliki Argiana, Melanie Deutsch
Hereditary bleeding disorders include a group of diseases with abnormalities of coagulation. Prior to 1990, infection with hepatitis C virus (HCV) was mainly transmitted via pooled plasma products as a treatment for hereditary bleeding disorders. Anti-HCV positivity in these patients may be as high as >70% in some areas, while some of them have also been coinfected with human immunodeficiency virus. Since about 20% of HCV-infected patients clear the infection naturally, chronic HCV infection represents a significant health problem in this group of patients...
January 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29331069/cellular-membrane-trafficking-machineries-utilized-by-the-hepatitis-viruses
#5
REVIEW
Jun Inoue, Masashi Ninomiya, Tooru Shimosegawa, Mark A McNiven
While the life cycles of hepatitis viruses (hepatitis A, B, C, D, and E viruses) have been modestly characterized, recent intensive studies have provided new insights. Because these viruses 'hijack' the membrane trafficking of the host cell machinery during replicative propagation, it is essential to determine and understand these specific cellular pathways. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are well known as a leading cause of liver cirrhosis and hepatocellular carcinoma. While substantial inroads toward treating HCV patients have recently been made, patients with HBV continue to require life-long treatment, which makes a thorough understanding of the HBV life cycle essential...
January 13, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29330989/hepatitis-b-and-hepatitis-c-virus-in-women-with-first-pregnancy
#6
Shandana Mustafa Jadoon, Muhammad Adeel, Shaheen Aslam, Ahsan Rasool
BACKGROUND: Hepatitis B and Hepatitis C are amongst the leading causes of morbidity and mortality in pregnant women throughout the globe. This study is aimed at determining the frequency of these infections among primigravid females and the common factors that make them prone to these infections. METHODS: This cross-sectional study was conducted at Ayub Teaching Hospital, Abbottabad from December 2015 to May 2016. A total of 174 jaundiced primigravida patients were included in the study through non-probability consecutive sampling...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29330866/enteric-viruses-dissemination-in-a-private-reserve-of-natural-heritage
#7
T M Fumian, M Victoria, C B Vieira, J M Fioretti, M S Rocha, T Prado, F R Guimarães, N P da Gama, J M de Oliveira, A C O Mendes, A M C Gaspar, J D O Santos, M Chame, J P G Leite, M P Miagostovich
This study aimed to assess anthropogenic impact of surrounding population in the Private Reserve of Natural Heritage at Pantanal, the world's largest freshwater wetland ecosystem located in the center of South America. Viral etiologic agents of acute gastroenteritis as rotavirus A (RVA), noroviruses (NoV), human adenoviruses (HAdV), klassevirus (KV) and of hepatitis, as hepatitis A virus (HAV), were investigated in different aquatic matrices. Annual collection campaigns were carried out from 2009 to 2012, alternating dry and rainy seasons...
January 13, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29330728/analysis-of-plasma-tenascin-c-in-post-hcv-cirrhosis-a-prospective-study
#8
Jennifer H Benbow, April D Elam, Krista L Bossi, Danae L Massengill, Elizabeth Brandon-Warner, William E Anderson, Catherine R Culberson, Mark W Russo, Andrew S deLemos, Laura W Schrum
BACKGROUND AND AIM: Hepatitis C virus (HCV)-related cirrhosis, one of the most common etiologies of liver cirrhosis in the Western world, is a risk factor for hepatocellular carcinoma. To confirm and improve current effectiveness of screening and prognosis of patients with established cirrhosis, a credible, simple plasma biomarker is needed. Hepatic stellate cell activation, a pivotal event in cirrhosis development, results in increased secretion of extracellular matrix proteins, including tenascin-C (TnC)...
January 12, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29330418/hla-b-hla-c-and-kir-improve-the-predictive-value-of-ifnl3-for-hepatitis-c-spontaneous-clearance
#9
Mario Frias, Antonio Rivero-Juárez, Diego Rodriguez-Cano, Ángela Camacho, Pedro López-López, María Ángeles Risalde, Bárbara Manzanares-Martín, Teresa Brieva, Isabel Machuca, Antonio Rivero
IFNL3 is the strongest predictor of spontaneous resolution (SR) of hepatitis C virus (HCV), however, consideration of IFNL3 genotype alone is of limited clinical value for the prediction of SR or chronic HCV infection. The objective of this study was to analyze the impact of HLA-B, HLA-C and KIRs on SR, as well as their additive effects on the predictive value of the IFNL3 genotype. We conducted a retrospective study of HIV patients that included both SR and chronic HCV patients. In our study, 61.6% of patients with IFNL3 CC achieved SR, and 81...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329497/pharmacokinetic-interactions-between-elbasvir-grazoprevir-and-immunosuppressant-drugs-in-healthy-volunteers
#10
Hwa-Ping Feng, Luzelena Caro, Christine M Fandozzi, Zifang Guo, Jennifer Talaty, Dennis Wolford, Deborah Panebianco, Marian Iwamoto, Joan R Butterton, Wendy W Yeh
Elbasvir (EBR)/grazoprevir (GZR) may be coadministered with immunosuppressant drugs in posttransplant people who are infected with hepatitis C virus. The aim of the present study was to assess the safety and pharmacokinetic interactions between EBR and GZR and single doses of cyclosporine, tacrolimus, mycophenolate mofetil (MMF), and prednisone. This was a 4-part, open-label study in 58 healthy volunteers. Participants received single doses of cyclosporine 400 mg, tacrolimus 2 mg, MMF 1 g, or prednisone 40 mg alone or in the presence of once-daily EBR 50 mg/GZR 200 mg...
January 12, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29329373/co-existing-hepatitis-c-and-alcoholic-liver-disease-a-diminishing-indication-for-liver-transplantation
#11
Amanda Wieland, Gregory T Everson
Aims: To provide an overview of published literature on the interaction of alcohol and hepatitis C virus (HCV) in the accelerated progression of liver disease to cirrhosis as relates to decision-making for the management of the liver transplant candidate and recipient. Methods: General PubMed search was employed along with expert input to identify the relevant articles on the topic. The authors also utilized both backward and forward citation review of the relevant articles and reviews to identify articles on identified topic...
January 10, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29329149/an-electronic-health-record-based-intervention-to-promote-hepatitis-c-virus-testing-among-adults-born-between-1945-and-1965-a-cluster-randomized-trial
#12
https://www.readbyqxmd.com/read/29328881/factors-affecting-the-virological-response-among-chronic-hepatitis-c-virus-patients-in-yemen
#13
Zaid Mutahar Mohammed Alezzi, Ayman Yosry Abd El Rehim, Waleed Fouad Fathallah, Mansour Ali Alamrani, Fouad Hezam Othman
Hepatitis C virus (HCV) infection is increasingly seen as a major public health problem, threat, and concern worldwide. In Yemen about 1.7% of the population is infected with chronic hepatitis C. This study aimed to detect the predictors for response to pegylated interferon and ribavirin (Peg-IFN/RBV) in chronic HCV Yemeni patients. The study was conducted on 100 patients with chronic HCV who received Peg-IFN/RBV in the 48th Military Hospital in Sana'a Yemen, from 2011 to 2013. All patients were subjected to complete history taking, thorough clinical examinations, routine laboratory investigation, and abdominal ultrasonography...
January 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29328682/brief-report-prevalence-of-hepatitis-b-and-c-virus-infections-in-u-s-air-force-basic-military-trainees-who-donated-blood-2013-2016
#14
Douglas F Taylor, Ryan S Cho, Jason F Okulicz, Bryant J Webber, John G Gancayco
Hepatitis B virus (HBV) and hepatitis C virus (HCV) can cause significant morbidity in military service members. Prevalences of HBV and HCV infections among military recruits accessioning into the U.S. Air Force have not previously been described. The Joint Base San Antonio-Lackland Blood Donor Center was queried for the results of HBV and HCV screening tests among all basic military trainees who donated blood between 25 November 2013 and 16 April 2016. Other active and reserve component members were excluded...
December 2017: MSMR
https://www.readbyqxmd.com/read/29328556/coronary-artery-disease-in-decompensated-patients-undergoing-liver-transplantation-evaluation
#15
Samarth S Patel, Eiman Nabi, Luis Guzman, Antonio Abbate, Chandra Bhati, Richard T Stravitz, Trevor Reichman, Scott C Matherly, Carolyn Driscoll, Hannah Lee, Velimir A Luketic, Richard K Sterling, Arun J Sanyal, Vaishali Patel, Marlon Levy, Mohammad Shadab Siddiqui
Coronary artery disease (CAD) is an important contributor to morbidity and mortality in patients undergoing liver transplantation (LT). However, the current literature is limited by sampling bias and non-definitive assessment of CAD. AIM: The current study examines the prevalence of CAD via per protocol coronary angiography and its relationship to etiology of liver disease in patients undergoing LT evaluation (LTE). METHODS: Data on 228 patients was prospectively collected who had coronary angiography as part of LTE between 2011-2014...
January 12, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29328393/paediatric-virology-and-its-interaction-between-basic-science-and-clinical-practice-review
#16
Ioannis N Mammas, Anne Greenough, Maria Theodoridou, Anna Kramvis, Maria Rusan, Angeliki Melidou, Paraskevi Korovessi, Georgia Papaioannou, Alexia Papatheodoropoulou, Chryssie Koutsaftiki, Maria Liston, George Sourvinos, Demetrios A Spandidos
The 3rd Workshop on Paediatric Virology, which took place on October 7th, 2017 in Athens, Greece, highlighted the role of breast feeding in the prevention of viral infections during the first years of life. Moreover, it focused on the long-term outcomes of respiratory syncytial virus and rhinovirus infections in prematurely born infants and emphasised the necessity for the development of relevant preventative strategies. Other topics that were covered included the vaccination policy in relation to the migration crisis, mother‑to‑child transmission of hepatitis B and C viruses, vaccination against human papilloma viruses in boys and advances on intranasal live‑attenuated vaccination against influenza...
January 4, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29327821/chronic-kidney-disease-in-patients-with-chronic-hepatitis-c-virus-infection
#17
Omer Shahab, Pegah Golabi, Zobair M Younossi
Hepatitis C virus (HCV) infection affects many organs in the body, including the liver, kidneys, skin, joints and others. Although the hepatic manifestation of HCV has been widely studied, the extrahepatic manifestaions of HCV have not been fully appreciated. Studies have shown that patients with HCV have a higher risk of chronic kidney disease and end-stage renal disease, as well as poorer outcomes after kidney transplantation. Given these findings, it is important to screen HCV patients for presence of renal impairement in a timely manner...
January 10, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29327320/phylogenetic-analysis-and-biological-evaluation-of-marine-endophytic-fungi-derived-from-red-sea-sponge-hyrtios-erectus
#18
Mervat Morsy Abbas Ahmed El-Gendy, Shaymaa M M Yahya, Ahmed R Hamed, Maha M Soltan, Ahmed Mohamed Ahmed El-Bondkly
Forty-four endophytic fungal isolates obtained from marine sponge, Hyrtios erectus, were evaluated and screened for their hydrolase activities. Most of the isolates were found to be prolific producers of hydrolytic enzymes. Only 11 isolates exhibited maximum cellular contents of lipids, rhamnolipids, and protein in the fungal isolates under the isolation numbers MERVA5, MERVA22, MERVA25, MERVA29, MERVA32, MERVA34, MERV36, MERVA39, MERVA42, MERVA43, and MERVA44. These isolate extracts exhibit the highest reducing activities against carbohydrate-metabolizing enzymes including α-amylase, α-glucosidase, β-glucosidase, β-glucuronidase, and tyrosinase...
January 12, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29327233/dcaf1-is-involved-in-hcv-replication-through-regulation-of-mir-122
#19
Yanling Yan, Conghui Li, Binlian Sun, Rongge Yang
Hepatitis C virus (HCV) is a worldwide threaten to human health with a high ratio of chronic infections. Recently, we found that Vpr-mediated regulation of HCV replication depends on the host protein DDB1-Cul4 associate factor 1 (DCAF1), implying that DCAF1 might be involved in the replication of HCV. In this study, we demonstrated that DCAF1 knockdown reduced HCV replication both in the infectious (JFH1) and replicon (Con1) systems. Further investigation showed a negative regulation of HCV internal ribosome entry site (IRES)-mediated translation by DCAF1...
January 11, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29326823/lichen-planus-following-tetanus-diphtheria-acellular-pertussis-vaccination-a-case-report-and-review-of-the-literature
#20
Heather C Rosengard, Chikoti M Wheat, Matthew P Tilson, Jonathan D Cuda
Lichen planus is an inflammatory dermatosis with a prevalence of approximately 1%. Recent meta-analyses show that patients with hepatitis C virus have a 2.5- to 4.5-fold increased risk of developing lichen planus. Lichen planus has also followed vaccinations and has specifically been attributed to the hepatitis B vaccine, the influenza vaccine, and the tetanus-diphtheria-acellular pertussis vaccine. We describe a case of lichen planus in a hepatitis C virus-infected African American male occurring in temporal association with the administration of the tetanus-diphtheria-acellular pertussis vaccine...
2018: SAGE Open Medical Case Reports
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