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JOURNAL ARTICLE
Jordan B Strom, Monica Mukherjee, Lauren Beussink-Nelson, Julius M Gardin, Benjamin H Freed, Sanjiv J Shah, Jonathan Afilalo
BACKGROUND: Normalization of echocardiographic chamber measurements for body surface area may result in misclassification of individuals with obesity or sarcopenia. Normalization for alternative measures of body size may be preferable, but there remains a dearth of information on their normative values and association with cardiovascular function metrics. METHODS AND RESULTS: A total of 3032 individuals underwent comprehensive 2-dimensional echocardiography at Exam 6 in MESA (Multi-Ethnic Study of Atherosclerosis)...
April 3, 2024: Journal of the American Heart Association
#2
JOURNAL ARTICLE
Jonathan Afilalo
No abstract text is available yet for this article.
March 6, 2024: European Heart Journal
#3
JOURNAL ARTICLE
Yang Zhan, Matthias G Friedrich, Nandini Dendukuri, Yang Lu, Michael Chetrit, Ian Schiller, Lawrence Joseph, Jaime L Shaw, Michael L Chuang, Johannes H Riffel, Warren J Manning, Jonathan Afilalo
BACKGROUND: Cardiovascular magnetic resonance (CMR) reference values are relied upon to accurately diagnose left ventricular (LV) and right ventricular (RV) pathologies. To date, reference values have been derived from modest sample sizes with limited patient diversity and attention to 1 but not both commonly used tracing techniques for papillary muscles and trabeculations. We sought to overcome these limitations by meta-analyzing normal reference values for CMR parameters stemming from multiple countries, vendors, analysts, and patient populations...
February 2024: Circulation. Cardiovascular Imaging
#4
JOURNAL ARTICLE
Louis Mullie, Jonathan Afilalo, Patrick Archambault, Rima Bouchakri, Kip Brown, David L Buckeridge, Yiorgos Alexandros Cavayas, Alexis F Turgeon, Denis Martineau, François Lamontagne, Martine Lebrasseur, Renald Lemieux, Jeffrey Li, Michaël Sauthier, Pascal St-Onge, An Tang, William Witteman, Michaël Chassé
OBJECTIVES: Distributed computations facilitate multi-institutional data analysis while avoiding the costs and complexity of data pooling. Existing approaches lack crucial features, such as built-in medical standards and terminologies, no-code data visualizations, explicit disclosure control mechanisms, and support for basic statistical computations, in addition to gradient-based optimization capabilities. MATERIALS AND METHODS: We describe the development of the Collaborative Data Analysis (CODA) platform, and the design choices undertaken to address the key needs identified during our survey of stakeholders...
December 21, 2023: Journal of the American Medical Informatics Association: JAMIA
#5
Monica Mukherjee, Jordan B Strom, Jonathan Afilalo, Mo Hu, Lauren Beussink-Nelson, Jiwon Kim, Karima Addetia, Alain Bertoni, John Gottdiener, Erin D Michos, Julius M Gardin, Sanjiv J Shah, Benjamin H Freed
BACKGROUND: Echocardiographic (2DE) thresholds indicating disease or impaired functional status compared to normal physiologic aging in individuals ≥ 65 years are not clearly defined. In the present study, we sought to establish standard values for 2DE parameters related to chamber size and function in older adults without cardiopulmonary or cardiometabolic conditions. METHODS: In this cross-sectional study of 3032 individuals who underwent 2DE at Exam 6 in the Multi-Ethnic Study of Atherosclerosis (MESA), 608 participants fulfilled our inclusion criteria, with normative values defined as the mean value ± 1...
December 7, 2023: medRxiv
#6
Quin E Denfeld, Sunita R Jha, Erik Fung, Tiny Jaarsma, Mathew S Maurer, Gordon R Reeves, Jonathan Afilalo, Nadine Beerli, Lavanya Bellumkonda, Sabina De Geest, Eiran Z Gorodeski, Emer Joyce, Jon Kobashigawa, Oliver Mauthner, Julee McDonagh, Izabella Uchmanowicz, Victoria Vaughan Dickson, JoAnn Lindenfeld, Peter Macdonald
Frailty is increasingly recognized as a salient condition in patients with heart failure (HF) as previous studies have determined that frailty is highly prevalent and prognostically significant, particularly in those with advanced HF. Definitions of frailty have included a variety of domains, including physical performance, sarcopenia, disability, comorbidity, and cognitive and psychological impairments, many of which are common in advanced HF. Multiple groups have recently recommended incorporating frailty assessments into clinical practice and research studies, indicating the need to standardize the definition and measurement of frailty in advanced HF...
November 29, 2023: Journal of Heart and Lung Transplantation
#7
JOURNAL ARTICLE
Rosie Fountotos, Sandra Lauck, Nicolo Piazza, Giuseppe Martucci, Rakesh Arora, Anita Asgar, Jessica Forcillo, Remi Kouz, Marino Labinaz, Andre Lamy, Mark Peterson, Harindra Wijeysundera, Lisa Masse, Marie-Claude Ouimet, Jopie Polderman, John Webb, Jonathan Afilalo
BACKGROUND: Despite the high procedural success of transcatheter aortic valve replacement (TAVR), 2 out of 5 older adults report poor physical performance and health-related quality of life (HRQOL) in the ensuing months, particularly those with frailty. There has yet to be a trial examining the synergistic effects of exercise and protein supplementation to counteract frailty and improve patient-centered outcomes following TAVR. METHODS: The PERFORM-TAVR trial is a multicenter parallel-group randomized clinical trial that is enrolling 200 frail older adults ≥70 years undergoing TAVR (NCT03522454)...
December 3, 2023: Canadian Journal of Cardiology
#8
JOURNAL ARTICLE
Tadhg Prendiville, Aoife Leahy, Ahmed Gabr, Fayeza Ahmad, Jonathan Afilalo, Glen Philip Martin, Mamas Mamas, Ivan P Casserly, Abdirahman Mohamed, Anastasia Saleh, Elaine Shanahan, Margaret O'Connor, Rose Galvin
OBJECTIVES: Assessment of frailty prior to aortic valve intervention is recommended in European and North American valvular heart disease guidelines. However, there is a lack of consensus on how it is best measured. The Clinical Frailty Scale (CFS) is a well-validated measure of frailty that is relatively quick to calculate. This meta-analysis sought to examine whether the CFS predicts mortality and morbidity following either transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR)...
August 2023: Open Heart
#9
JOURNAL ARTICLE
Chen-Yang Su, Sirui Zhou, Edgar Gonzalez-Kozlova, Guillaume Butler-Laporte, Elsa Brunet-Ratnasingham, Tomoko Nakanishi, Wonseok Jeon, David R Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Meriem Bouab, Louis Petitjean, Charlotte Guzman, Xiaoqing Xue, Chris Tselios, Branka Vulesevic, Olumide Adeleye, Tala Abdullah, Noor Almamlouk, Yara Moussa, Chantal DeLuca, Naomi Duggan, Erwin Schurr, Nathalie Brassard, Madeleine Durand, Diane Marie Del Valle, Ryan Thompson, Mario A Cedillo, Eric Schadt, Kai Nie, Nicole W Simons, Konstantinos Mouskas, Nicolas Zaki, Manishkumar Patel, Hui Xie, Jocelyn Harris, Robert Marvin, Esther Cheng, Kevin Tuballes, Kimberly Argueta, Ieisha Scott, Celia M T Greenwood, Clare Paterson, Michael A Hinterberg, Claudia Langenberg, Vincenzo Forgetta, Joelle Pineau, Vincent Mooser, Thomas Marron, Noam D Beckmann, Seunghee Kim-Schulze, Alexander W Charney, Sacha Gnjatic, Daniel E Kaufmann, Miriam Merad, J Brent Richards
Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully understood. To approach this problem, we measured 4701 circulating human protein abundances in two independent cohorts totaling 986 individuals. We then trained prediction models including protein abundances and clinical risk factors to predict COVID-19 severity in 417 subjects and tested these models in a separate cohort of 569 individuals. For severe COVID-19, a baseline model including age and sex provided an area under the receiver operator curve (AUC) of 65% in the test cohort...
April 17, 2023: Scientific Reports
#10
JOURNAL ARTICLE
Joseph Somech, Aayushi Joshi, Rita Mancini, Jessica Chetrit, Caroline Michel, Richard Sheppard, Viviane Nguyen, Mathieu Walker, Nadia Giannetti, Abhinav Sharma, Delina Maghakian, Esther Laforest, Jonathan Afilalo
Background Frailty is prevalent in older adults with heart failure and is associated with poor outcomes; however, there remains uncertainty on how to measure frailty in clinical practice. Methods and Results A multicentric prospective cohort study was assembled at 4 heart failure clinics to compare the prognostic value of 3 physical frailty scales in ambulatory patients with heart failure. Outcomes were all-cause death or hospitalization and health-related quality of life using the 36-Item Short Form survey questionnaire (SF-36) at 3 months...
March 9, 2023: Journal of the American Heart Association
#11
JOURNAL ARTICLE
Satoshi Yoshiji, Guillaume Butler-Laporte, Tianyuan Lu, Julian Daniel Sunday Willett, Chen-Yang Su, Tomoko Nakanishi, David R Morrison, Yiheng Chen, Kevin Liang, Michael Hultström, Yann Ilboudo, Zaman Afrasiabi, Shanshan Lan, Naomi Duggan, Chantal DeLuca, Mitra Vaezi, Chris Tselios, Xiaoqing Xue, Meriem Bouab, Fangyi Shi, Laetitia Laurent, Hans Markus Münter, Marc Afilalo, Jonathan Afilalo, Vincent Mooser, Nicholas J Timpson, Hugo Zeberg, Sirui Zhou, Vincenzo Forgetta, Yossi Farjoun, J Brent Richards
Obesity is a major risk factor for Coronavirus disease (COVID-19) severity; however, the mechanisms underlying this relationship are not fully understood. As obesity influences the plasma proteome, we sought to identify circulating proteins mediating the effects of obesity on COVID-19 severity in humans. Here, we screened 4,907 plasma proteins to identify proteins influenced by body mass index using Mendelian randomization. This yielded 1,216 proteins, whose effect on COVID-19 severity was assessed, again using Mendelian randomization...
February 2023: Nature metabolism
#12
JOURNAL ARTICLE
Julia Rodighiero, Ali M Alakhtar, Nouf Baker, Ali Zgheib, Benoit de Varennes, Kevin Lachapelle, Renzo Cecere, Patrick Ergina, Christo Tchervenkov, Dominique Shum-Tim, Giuseppe Martucci, Nicolo Piazza, Jonathan Afilalo, Marco Spaziano
BACKGROUND: This study sought to compare characteristics and outcomes of patients who underwent surgical aortic valve replacement (SAVR) after being referred to a heart team (HT), to those of patients referred directly for SAVR. METHODS: An analysis of patients who underwent SAVR from 2015 to 2020 was conducted. Patients were categorized into 3 groups, as follows: (i) H-HT: patients referred to the HT from 2015 to 2017 (historical cohort); (ii) C-HT: patients referred to the HT from 2018 to 2020 (contemporary cohort); and (iii) No-HT: patients referred directly to cardiac surgery from 2018 to 2020...
January 2023: CJC open
#13
RANDOMIZED CONTROLLED TRIAL
Rosie Fountotos, Fayeza Ahmad, Neetika Bharaj, Haroon Munir, John Marsala, Lawrence G Rudski, Michael Goldfarb, Jonathan Afilalo
BACKGROUND: Hospitalization for cardiovascular disease (CVD) may be complicated by hospital-acquired disability (HAD) and subsequently poor health-related quality of life (HRQOL). While frailty has been shown to be a risk factor, it has yet to be studied as a therapeutic target to improve outcomes. OBJECTIVES: This trial sought to determine the effects of an in-hospital multicomponent intervention targeting physical weakness, cognitive impairment, malnutrition, and anemia on patient-centered outcomes compared to usual care...
May 2023: Journal of the American Geriatrics Society
#14
JOURNAL ARTICLE
Christine Pacheco, Maxime Tremblay-Gravel, Guillaume Marquis-Gravel, Etienne Couture, Robert Avram, Olivier Desplantie, Lior Bibas, François Simard, Isabelle Malhamé, Anthony Poulin, Dan Tran, Mario Senechal, Jonathan Afilalo, Paul Farand, Lyne Bérubé, E Marc Jolicoeur, Anique Ducharme, François Tournoux
BACKGROUND: Peripartum cardiomyopathy (PPCM) is associated with severe morbidity and mortality, and the significance of right ventricular (RV) involvement is unclear. We sought to determine whether RV systolic dysfunction or dilatation is associated with adverse clinical outcomes in women with PPCM. METHODS: We conducted a multicentre retrospective cohort study examining the association between echocardiographic RV systolic dysfunction or dilatation at the time of PPCM diagnosis and clinical outcomes...
November 2022: CJC open
#15
JOURNAL ARTICLE
Thiago Quinaglia, Carlos Gongora, Magid Awadalla, Malek Z O Hassan, Amna Zafar, Zsofia D Drobni, Syed S Mahmood, Lili Zhang, Otavio R Coelho-Filho, Giselle A Suero-Abreu, Muhammad A Rizvi, Gagan Sahni, Anant Mandawat, Eduardo Zatarain-Nicolás, Michael Mahmoudi, Ryan Sullivan, Sarju Ganatra, Lucie M Heinzerling, Franck Thuny, Stephane Ederhy, Hannah K Gilman, Supraja Sama, Sofia Nikolaidou, Ana González Mansilla, Antonio Calles, Marcella Cabral, Francisco Fernández-Avilés, Juan José Gavira, Nahikari Salterain González, Manuel García de Yébenes Castro, Ana Barac, Jonathan Afilalo, Daniel A Zlotoff, Leyre Zubiri, Kerry L Reynolds, Richard Devereux, Judy Hung, Michael H Picard, Eric H Yang, Dipti Gupta, Caroline Michel, Alexander R Lyon, Carol L Chen, Anju Nohria, Michael G Fradley, Paaladinesh Thavendiranathan, Tomas G Neilan
BACKGROUND: Global circumferential strain (GCS) and global radial strain (GRS) are reduced with cytotoxic chemotherapy. There are limited data on the effect of immune checkpoint inhibitor (ICI) myocarditis on GCS and GRS. OBJECTIVES: This study aimed to detail the role of GCS and GRS in ICI myocarditis. METHODS: In this retrospective study, GCS and GRS from 75 cases of patients with ICI myocarditis and 50 ICI-treated patients without myocarditis (controls) were compared...
November 2022: JACC. Cardiovascular Imaging
#16
JOURNAL ARTICLE
Guillaume Butler-Laporte, Edgar Gonzalez-Kozlova, Chen-Yang Su, Sirui Zhou, Tomoko Nakanishi, Elsa Brunet-Ratnasingham, David Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Meriem Bouab, Louis Petitjean, Charlotte Guzman, Xiaoqing Xue, Chris Tselios, Branka Vulesevic, Olumide Adeleye, Tala Abdullah, Noor Almamlouk, Yara Moussa, Chantal DeLuca, Naomi Duggan, Erwin Schurr, Nathalie Brassard, Madeleine Durand, Diane Marie Del Valle, Ryan Thompson, Mario A Cedillo, Eric Schadt, Kai Nie, Nicole W Simons, Konstantinos Mouskas, Nicolas Zaki, Manishkumar Patel, Hui Xie, Jocelyn Harris, Robert Marvin, Esther Cheng, Kevin Tuballes, Kimberly Argueta, Ieisha Scott, Celia M T Greenwood, Clare Paterson, Michael Hinterberg, Claudia Langenberg, Vincenzo Forgetta, Vincent Mooser, Thomas Marron, Noam Beckmann, Ephraim Kenigsberg, Alexander W Charney, Seunghee Kim-Schulze, Miriam Merad, Daniel E Kaufmann, Sacha Gnjatic, J Brent Richards
INTRODUCTION: Severe COVID-19 leads to important changes in circulating immune-related proteins. To date it has been difficult to understand their temporal relationship and identify cytokines that are drivers of severe COVID-19 outcomes and underlie differences in outcomes between sexes. Here, we measured 147 immune-related proteins during acute COVID-19 to investigate these questions. METHODS: We measured circulating protein abundances using the SOMAscan nucleic acid aptamer panel in two large independent hospital-based COVID-19 cohorts in Canada and the United States...
September 28, 2022: Clinical Proteomics
#17
JOURNAL ARTICLE
Fayeza Ahmad, Rosie Fountotos, Michael Goldfarb, Neetika Bharaj, Haroon Munir, John Marsala, Lawrence G Rudski, Jonathan Afilalo
AIMS: Frailty is disproportionately prevalent in cardiovascular disease patients and exacerbated during hospital admissions, heightening the risk for adverse events and functional decline. Using the Essential Frailty Toolset (EFT) to target physical weakness, cognitive impairment, malnourishment, and anemia, we tested a multicomponent intervention to de-frail older adults with acute cardiovascular conditions during their hospital admission. METHODS AND RESULTS: The TARGET-EFT trial was a single-center randomized clinical trial at the Jewish General Hospital, Montreal, Canada...
August 26, 2022: European Heart Journal. Quality of Care & Clinical Outcomes
#18
REVIEW
Luigina Guasti, Polychronis Dilaveris, Mamas A Mamas, Dimitrios Richter, Ruxandra Christodorescu, Joost Lumens, Mark J Schuuring, Stefano Carugo, Jonathan Afilalo, Marc Ferrini, Riccardo Asteggiano, Martin R Cowie
Digital health technology is receiving increasing attention in cardiology. The rise of accessibility of digital health tools including wearable technologies and smart phone applications used in medical practice has created a new era in healthcare. The coronavirus pandemic has provided a new impetus for changes in delivering medical assistance across the world. This Consensus document discusses the potential implementation of digital health technology in older adults, suggesting a practical approach to general cardiologists working in an ambulatory outpatient clinic, highlighting the potential benefit and challenges of digital health in older patients with, or at risk of, cardiovascular disease...
July 12, 2022: ESC Heart Failure
#19
RANDOMIZED CONTROLLED TRIAL
Abhinav Sharma, Malik Elharram, Jonathan Afilalo, Alexandria Flannery, Marc Afilalo, Chris Tselios, Jiayi Ni, Justin A Ezekowitz, Matthew P Cheng, Andrew P Ambrosy, Faiez Zannad, James M Brophy, Nadia Giannetti, Amal Bessissow, Nadine Kronfli, Ariane Marelli, Haya Aziz, Mohammad Alqahtani, Mona Aflaki, Morgan Craig, Renato D Lopes, João Pedro Ferreira
BACKGROUND: Renin-angiotensin aldosterone system inhibitors (RAASi) are commonly used among patients hospitalized with a severe acute respiratory syndrome coronavirus 2 infection coronavirus disease 2019 (COVID-19). We evaluated whether continuation versus discontinuation of RAASi were associated with short term clinical or biochemical outcomes. METHODS: The RAAS-COVID-19 trial was a randomized, open label study in adult patients previously treated with RAASi who are hospitalized with COVID-19 (NCT04508985)...
May 2022: American Heart Journal
#20
EDITORIAL
Lawrence G Rudski, Jonathan Afilalo
No abstract text is available yet for this article.
February 8, 2022: Journal of the American College of Cardiology
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