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https://www.readbyqxmd.com/read/28449186/the-risk-of-lower-gastrointestinal-bleeding-in-low-dose-aspirin-users
#1
W-C Chen, K-H Lin, Y-T Huang, T-J Tsai, W-C Sun, S-K Chuah, D-C Wu, P-I Hsu
BACKGROUND: Aspirin increases the risk of gastrointestinal bleeding. AIM: To investigate the risk of lower gastrointestinal bleeding (LGIB) in aspirin users. METHODS: Low-dose (75-325 mg daily) aspirin users and controls matched by age, gender and enrollment time in a 1:5 ratio were selected from 1 million randomly sampled subjects in the National Health Insurance Research Database of Taiwan. Cox proportional hazard regression models were developed to evaluate the predictors of LGIB with adjustments for age, gender, comorbidities including coronary artery disease, ischaemic stroke, diabetes, hypertension, chronic kidney disease, liver cirrhosis, chronic obstructive pulmonary disease, dyslipidemia, uncomplicated peptic ulcer disease, history of peptic ulcer bleeding, and concomitant use of clopidogrel, ticlopidine, warfarin, nonsteroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase-2 inhibitors, steroids, proton pump inhibitors (PPIs), histamine-2 receptor antagonists (H2RAs), nitrates, alendronate, selective serotonin reuptake inhibitors (SSRIs) and calcium channel blockers...
April 27, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28449076/qtl-analysis-of-the-developmental-response-to-l-glutamate-in-arabidopsis-roots-and-its-genotype-by-environment-interactions
#2
Pia Walch-Liu, Rhonda C Meyer, Thomas Altmann, Brian G Forde
Primary root growth in Arabidopsis and a number of other species has previously been shown to be remarkably sensitive to the presence of external glutamate, with glutamate signalling eliciting major changes in root architecture. Using two recombinant inbred lines from reciprocal crosses between Arabidopsis accessions C24 and Col-0, we have identified one large-effect quantitative trait locus (QTL), GluS1, and two minor QTLs, GluS2 and GluS3, which together accounted for 41% of the phenotypic variance in glutamate sensitivity...
April 26, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28448941/geochemistry-and-microbial-diversity-of-cave-waters-in-the-gypsum-karst-aquifers-of-emilia-romagna-region-italy
#3
Ilenia M D'Angeli, Diana I Serrazanetti, Chiara Montanari, Lucia Vannini, Fausto Gardini, Jo De Waele
Fifty-seven control points of waters (sinking streams, rivers in caves, and resurgences) hosted in gypsum karst areas in Emilia Romagna region (N-Italy) were sampled in the framework of a Project LIFE+08NAT/IT/000369 "Gypsum" in the period 2010-2014. The microbiology and chemistry of these waters have been analyzed to evaluate the impact of human activities or natural factors, in the gypsum karst systems. Waters have been analyzed for major chemistry (Ca, Mg, Na, K, SO4, HCO3, Cl, NO3) and some minor constituents (F, Br, NH4 and PO4), measuring pH, electric conductivity (EC), total dissolved solids (TDS) and temperature (T) in situ...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448907/characterization-of-typical-metal-particles-during-haze-episodes-in-shanghai-china
#4
Rui Li, Xin Yang, Hongbo Fu, Qingqing Hu, Liwu Zhang, Jianmin Chen
Aerosol particles were collected during three heavy haze episodes at Shanghai in the winter of 2013. Transmission electron microscopy (TEM) coupled with energy dispersive X-ray spectroscopy was used to study the morphology and speciation of typical metal particles at a single-particle level. In addition, time-of-flight aerosol mass spectrometry (ATOFMS) was applied to identify the speciation of the Fe-containing particles. TEM analysis indicated that various metal-containing particles were hosted by sulfates, nitrates, and oxides...
April 19, 2017: Chemosphere
https://www.readbyqxmd.com/read/28448452/a-wireless-sensor-network-for-growth-environment-measurement-and-multi-band-optical-sensing-to-diagnose-tree-vigor
#5
Shinichi Kameoka, Shuhei Isoda, Atsushi Hashimoto, Ryoei Ito, Satoru Miyamoto, Genki Wada, Naoki Watanabe, Takashi Yamakami, Ken Suzuki, Takaharu Kameoka
We have tried to develop the guidance system for farmers to cultivate using various phenological indices. As the sensing part of this system, we deployed a new Wireless Sensor Network (WSN). This system uses the 920 MHz radio wave based on the Wireless Smart Utility Network that enables long-range wireless communication. In addition, the data acquired by the WSN were standardized for the advanced web service interoperability. By using these standardized data, we can create a web service that offers various kinds of phenological indices as secondary information to the farmers in the field...
April 27, 2017: Sensors
https://www.readbyqxmd.com/read/28448172/the-macrophage-stimulating-anti-cancer-agent-rrx-001-protects-against-ischemia-reperfusion-injury
#6
Pedro Cabrales, Scott Caroen, Arnold Oronsky, Corey Carter, Jane Trepel, Thomas Summers, Tony Reid, Neil Oronsky, Michelle Lybeck, Bryan Oronsky
Introduction RRx-001, a clinical macrophage-stimulating anti-cancer agent that also produces nitric oxide (NO) was studied in a model of ischemia-reperfusion injury. Methods The production of NO is dependent on the oxygen tension because nitric oxide synthases convert l-arginine to NO and l-citrulline in the presence of O2. Since the P450 enzymes, which metabolize nitrate esters such as nitroglycerin are dependent on oxygen, the generation of 'exogenous' NO is also sensitive to alterations in tissue PO2. I/R injury was studied in a hamster chamber window, with compression of the periphery of the window for 1 hour to induce ischemia...
April 27, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28448146/radical-nitration-debromination-of-%C3%AE-bromo-%C3%AE-fluoroalkenes-as-a-stereoselective-route-to-aromatic-%C3%AE-fluoronitroalkenes-functionalized-fluorinated-building-blocks-for-organic-synthesis
#7
Vladimir A Motornov, Vasiliy M Muzalevskiy, Andrey A Tabolin, Roman A Novikov, Yulia V Nelyubina, Valentine G Nenajdenko, Sema L Ioffe
A new highly efficient method for the synthesis of 2-fluoro-2-nitrostyrenes was described. Radical nitration of readily available 2-bromo-2-fluorostyrenes with Fe(NO3)3∙9H2O resulted in the formation of the corresponding α-fluoro-nitroalkenes in isolated yields up to 92%. The reaction proceeded as a nitration-debromination sequence to highly stereoselectively give α-fluoro-nitroalkenes as Z-isomers only. The broad scope of this method was demonstrated. Prepared monofluorinated alkenes were shown to be versatile building blocks for the synthesis of various fluorinated products...
April 27, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28448144/a-maldiisotopic-approach-to-discover-natural-products-cryptomaldamide-a-hybrid-tripeptide-from-the-marine-cyanobacterium-moorea-producens
#8
Robin B Kinnel, Eduardo Esquenazi, Tiago Leao, Nathan Moss, Emily Mevers, Alban R Pereira, Emily A Monroe, Anton Korobeynikov, Thomas F Murray, David Sherman, Lena Gerwick, Pieter C Dorrestein, William H Gerwick
Genome sequencing of microorganisms has revealed a greatly increased capacity for natural products biosynthesis than was previously recognized from compound isolation efforts alone. Hence, new methods are needed for the discovery and description of this hidden secondary metabolite potential. Here we show that provision of heavy nitrogen (15)N-nitrate to marine cyanobacterial cultures followed by single-filament MALDI analysis over a period of days was highly effective in identifying a new natural product with an exceptionally high nitrogen content...
April 27, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28448139/suppression-of-nitrite-oxidizing-bacteria-in-intermittently-membrane-aerated-biofilms-a-model-based-explanation
#9
Yunjie Ma, Carlos Domingo-Félez, Benedek Gy Plosz, Barth F Smets
Autotrophic ammonium oxidation in membrane-aerated biofilm reactors (MABRs) can make treatment of ammonium-rich wastewaters more energy-efficient, especially within the context of short-cut ammonium removal. The challenge is to exclusively enrich ammonium-oxidizing bacteria (AOB). To achieve nitritation, strategies to suppress nitrite-oxidizing bacteria (NOB) are needed, which are ideally grounded on an understanding of underlying mechanisms. In this study, a counter-diffusion nitrifying biofilm reactor was operated under intermittent aeration...
April 27, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28448126/from-surprising-solvothermal-reaction-to-uncommon-zinc-ii-catalyzed-aromatic-c-h-activation-reaction-for-direct-nitroquinoline-synthesis
#10
Yazhen Wang, Feihu Yu, Xiao Han, Ming Li, Yue Tong, Jie Ding, Hongwei Hou
In this work, we first found a surprising solvothermal reaction for direct dinitration of quinoline derivative. To explore the application in direct nitroquinoline synthesis, this reaction was subsequently modified as an equivalent reaction in a Schlenk tube. More significantly, after a constant attempt, nitrated derivative was obtained in optimized condition with a zinc(II) sulfate catalyst, where some substrates with strong electron-withdrawing group were first nitrated by a directly catalyzed condition. This new zinc(II)-catalyzed aromatic C-H activation reaction is the first example of direct dinitration by a single catalyst, which will be a new facile and environmentally friendly strategy to access synthetically useful nitroquinoline derivative...
April 27, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28447506/anti-inflammatory-and-gastroprotective-potential-of-leaf-essential-oil-of-cinnamomum-glanduliferum-in-ethanol-induced-rat-experimental-gastritis
#11
Samar S Azab, Gehad A Abdel Jaleel, Omayma A Eldahshan
CONTEXT: Nothing could be found in the literature concerning Cinnamomum glanduliferum (Wall) Meissn (Lauraceae) bark (CG) in Egypt. OBJECTIVE: To investigate CG volatile oil chemically and its anti-inflammatory and gastroprotective effects. MATERIALS AND METHODS: Essential oils were investigated by GC-MS. Leaves oil was assessed at doses of 250, 500 and 1000 mg/kg for its anti-inflammatory effect against carrageenan-induced rat oedema model...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28447463/screening-of-debaryomyces-hansenii-strains-for-flavor-production-under-reduced-concentration-of-nitrifying-preservatives-used-in-meat-products
#12
Monica Flores, Daniel Moncunill, Rebeca Montero, Jose Javier López-Díez, Carmela Belloch
Fifteen D. hansenii strains from different food origins were genetically characterised and tested on a culture medium resembling the composition of fermented sausages but different concentrations of nitrifying preservatives. Genetic typing of the D. hansenii strains revealed two levels of discrimination, isolation source or strain specific. Different ability to proliferate on culture media containing different concentrations of nitrate and nitrite, as sole nitrogen sources and in presence of amino acids, was observed within D...
April 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28447452/a-single-usage-of-a-kitchen-degreaser-can-alter-indoor-aerosol-composition-for-days
#13
Jaroslav Schwarz, Otakar Makeš, Jakub Ondráček, Michael Cusack, Nicholas Talbot, Petr Vodička, Lucie Kubelova, Vladimir Zdimal
To the best of our knowledge, this study represents the first observation of multi-day persistence of an indoor aerosol transformation linked to a kitchen degreaser containing mono-ethanol amine (MEA). MEA remaining on the cleaned surfaces and on a wiping paper towel in a trash can was able to transform ammonium sulfate and ammonium nitrate into (MEA)2SO4 and (MEA)NO3. This influence persisted for at least 60 hours despite a high average ventilation rate. The influence was observed using both offline (filters, impactors, and ion chromatography analysis) and online (compact time-of-flight aerosol mass spectrometer) techniques...
April 27, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28446901/anaerobic-methanotrophic-archaea-of-the-anme-2d-cluster-are-active-in-a-low-sulfate-iron-rich-freshwater-sediment
#14
Hannah S Weber, Kirsten S Habicht, Bo Thamdrup
ANaerobic MEthanotrophic (ANME) archaea remove the greenhouse gas methane from anoxic environments and diminish its flux to the atmosphere. High methane removal efficiencies are well documented in marine environments, whereas anaerobic oxidation of methane (AOM) was only recently indicated as an important methane sink in freshwater systems. Freshwater AOM-mediating microorganisms lack taxonomic identification and only little is known about metabolic adaptions to prevailing biogeochemical conditions. One of the first study sites providing information about AOM activity in freshwater sediment is Lake Ørn, a low-sulfate, iron-rich Danish lake...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28445543/comparative-genomic-analysis-between-corynebacterium-pseudotuberculosis-strains-isolated-from-buffalo
#15
Marcus Vinicius Canário Viana, Henrique Figueiredo, Rommel Ramos, Luis Carlos Guimarães, Felipe Luiz Pereira, Fernanda Alves Dorella, Salah Abdel Karim Selim, Mohammad Salaheldean, Artur Silva, Alice R Wattam, Vasco Azevedo
Corynebacterium pseudotuberculosis is a Gram-positive, pleomorphic, facultative intracellular pathogen that causes Oedematous Skin Disease (OSD) in buffalo. To better understand the pathogenic mechanisms of OSD, we performed a comparative genomic analysis of 11 strains of C. pseudotuberculosis isolated from different buffalo found to be infected in Egypt during an outbreak that occurred in 2008. Sixteen previously described pathogenicity islands (PiCp) were present in all of the new buffalo strains, but one of them, PiCp12, had an insertion that contained both a corynephage and a diphtheria toxin gene, both of which may play a role in the adaptation of C...
2017: PloS One
https://www.readbyqxmd.com/read/28445231/the-effects-of-multi-day-vs-single-pre-exercise-nitrate-supplement-dosing-on-simulated-cycling-time-trial-performance-and-skeletal-muscle-oxygenation
#16
Edward Jo, Michelle Fischer, Alexandra T Auslander, Alan Beigarten, Bruce Daggy, Ken Hansen, Lisa Kessler, Adam Osmond, Hong Wang, Rachel Wes
A transient augmentation in the metabolic efficiency of skeletal muscle is the purported basis for dietary nitrate supplementation amongst competitive and recreational athletes alike. Previous studies support the ergogenic effects of nitrate supplementation as findings indicated improved microvascular blood flow, exercise economy, and performance with relatively short-term supplementation. As with most ergogenic aids, the optimum duration of supplementation prior to performance or competition, i.e. loading phase, is a critical determinant for efficacy...
April 18, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28444690/strobilurins-as-growth-promoting-compounds-how-stroby-regulates-arabidopsis-leaf-growth
#17
Judith Van Dingenen, Chrystalla Antoniou, Panagiota Filippou, Jacob Pollier, Nathalie Gonzalez, Stijn Dhondt, Alain Goossens, Vasileios Fotopoulos, Dirk Inzé
Strobilurins are an important class of agrochemical fungicides used throughout the world on a wide variety of crops as protection against fungal pathogens. In addition to this protective role, they are reported to also positively influence plant physiology. In this study, we analyzed the effect of Stroby® WG, a commercially available fungicide consisting of 50% (w/w) kresoxim-methyl (KM) as active strobilurin compound, on Arabidopsis leaf growth. Treatment of seedlings with Stroby resulted in larger leaves due to an increase in cell number...
April 25, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28444566/improvement-of-rice-seedling-growth-and-nitrogen-use-efficiency-by-seed-inoculation-with-endophytic-denitrifiers
#18
Wenfeng Wang, Yanyan Zhai, Lixiang Cao, Hongming Tan, Renduo Zhang
The aim of the present study is to investigate the effect of seed inoculation with endophytic denitrifiers on rice seedling growth and nitrogen use efficiency under low- and high-urea conditions. Pseudomonas sp. B2, Streptomyces sp. A9, and Fusarium sp. F3 were isolated from rice plant tissues. Rice seeds inoculated with the denitrifiers were sown in soil fertilized with 100 and 300 mg/kg urea concentrations, respectively. The denitrifiers increased soil ammonia concentrations or kept high ammonia concentration for a longer time in soils...
April 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28444419/the-role-of-localized-acidity-generation-in-microbially-influenced-corrosion
#19
REVIEW
Yuriy Kryachko, Sean M Hemmingsen
Microbially influenced corrosion is of great industrial concern. Microbial coupling of metal oxidation to sulfate-, nitrate-, nitrite-, or CO2-reduction is proton-mediated, and some sulfate-reducing prokaryotes are capable of regulating extracellular pH. The analysis of the corrosive processes catalyzed by nitrate reducing bacteria and methanogenic archaea indicates that these microorganisms may be capable of regulating extracellular pH as well. It is proposed that nutrient limitation at metal-biofilm interfaces may induce activation of enzymatic proton-producing/proton-secreting functions in respiratory and methanogenic microorganisms to make them capable of using Fe(0) as the electron donor...
April 26, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28443934/hg-ii-and-pd-ii-complexes-with-a-new-selenoether-bridged-biscarbene-ligand-efficient-mono-and-bis-arylation-of-methyl-acrylate-with-a-pincer-biscarbene-pd-ii-precatalyst
#20
Rishu, Billa Prashanth, Deependra Bawari, Ushnish Mandal, Aditya Verma, Angshuman Roy Choudhury, Sanjay Singh
Two equivalents of 1-benzyl-3-bromoethylbenzimidazolium bromide couple with Na2Se to produce the first selenoether bridged bis-benzimidazolium salt (LH2)Br2. The nitrate (LH2)(NO3)2 and tetrafluoroborate (LH2)(BF4)2 salts were also synthesized from (LH2)Br2. The reaction of Hg(OAc)2 with (LH2)Br2 gave the first pseudo pincer carbene mercury complex, [Hg(L-κ(2)C)][HgBr4] (C1). Different complexes of Pd(ii) with selenoether bridged carbene were obtained using (LH2)Br2 and (LH2)(NO3)2. Syntheses of these complexes were dependent on the counter anion and the temperature...
April 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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