keyword
MENU ▼
Read by QxMD icon Read
search

Kidney transplant candidate

keyword
https://www.readbyqxmd.com/read/29052563/predictive-score-model-for-delayed-graft-function-based-on-easily-available-variables-before-kidney-donation-after-cardiac-death
#1
Chen-Guang Ding, Qian-Hui Tai, Feng Han, Yang Li, Xiao-Hui Tian, Pu-Xun Tian, Xiao-Ming Ding, Xiao-Ming Pan, Jin Zheng, He-Li Xiang, Wu-Jun Xue
BACKGROUND: How to evaluate the quality of donation after cardiac death (DCD) kidneys has become a critical problem in kidney transplantation in China. Hence, the aim of this study was to develop a simple donor risk score model to evaluate the quality of DCD kidneys before DCD. METHODS: A total of 543 qualified kidneys were randomized in a 2:1 manner to create the development and validation cohorts. The donor variables in the development cohort were considered as candidate univariate predictors of delayed graft function (DGF)...
October 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29050351/the-prognostic-significance-of-preoperative-left-ventricular-diastolic-dysfunction-and-left-atrial-enlargement-on-acute-coronary-syndrome-in-kidney-transplantation
#2
Jin Ho Hwang, Jun-Bean Park, Yong-Jin Kim, Jung Nam An, Jaeseok Yang, Curie Ahn, In Mok Jung, Chun Soo Lim, Yon Su Kim, Young Hoon Kim, Jung Pyo Lee
Echocardiography is commonly performed as a screening test to evaluate perioperative risks before kidney transplantation. However, only limited data are available on echocardiographic parameters of left ventricular diastolic dysfunction (LVDD) and left atrial enlargement (LAE) on acute coronary syndrome and mortality in kidney transplant recipients. We reviewed 2779 adult recipients who underwent pretransplant echocardiography from 1997 to 2012. We divided the patients into two and four groups by two categories: LVDD grades 0-1 vs...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29038394/factors-associated-with-lumbar-and-femoral-bone-mineral-density-in-kidney-transplants-candidates
#3
Mohammad Aghighi, Mitra Mahdavi Mazdeh, Mohsen Nafar, Vahid Rakhshan
INTRODUCTION: Data on risk factors associated with low bone mineral density are limited in patients with end-stage renal disease. This study evaluated the factors deemed associated with lumbar and femoral Z and T scores. MATERIALS AND METHODS: Clinical and demographic data of 98 patients waiting for kidney transplantation were collected, as well as lumbar and femoral bone densitometries, before transplantation. Osteoporosis and osteopenia and factors associated with bone mineral density were assessed...
October 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29037453/establishment-of-calculated-panel-reactive-antibody-and-its-potential-benefits-in-improving-the-kidney-allocation-strategy-in-taiwan
#4
Ssu-Wen Shen, Chun-Kai Chang, Yi-Shun Gao, Pin-Jou Hsu, Shuo-Chueh Cheng, Fei-Yun Liu, Shyh-Chyi Lo
BACKGROUND/PURPOSE: Renal transplant candidates who are highly sensitized to human leukocyte antigens (HLAs) tend to wait longer to find a matched donor and have poor outcomes. Most organ-sharing programs prioritize highly sensitized patients in the allocation scoring system. The HLA sensitization status is traditionally evaluated by the panel-reactive antibody (PRA) assay. However, this assay is method dependent and does not consider the ethnic differences in HLA frequencies. A calculated PRA (cPRA), based on a population's HLA frequency and patients' unacceptable antigens (UAs), correctly estimates the percentage of donors suitable for candidates...
October 13, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29033833/cell-based-therapies-for-tissue-fibrosis
#5
REVIEW
Rebecca Lim, Sharon D Ricardo, William Sievert
The development of tissue fibrosis in the context of a wound-healing response to injury is common to many chronic diseases. Unregulated or persistent fibrogenesis may lead to structural and functional changes in organs that increase the risk of significant morbidity and mortality. We will explore the natural history, epidemiology, and pathogenesis of fibrotic disease affecting the lungs, kidneys, and liver as dysfunction of these organs is responsible for a substantial proportion of global mortality. For many patients with end-stage disease, organ transplantation is the only effective therapy to prolong life...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29031488/-outcome-of-living-kidney-donors-for-transplantation
#6
Antoine Lanot, Nicolas Bouvier, Valérie Chatelet, Angélique Lecouf, Xavier Tillou, Bruno Hurault de Ligny
Nowadays, several treatments exist to treat terminal chronic renal failure. Best results for the recipients are obtained with kidney transplantation concerning mortality and quality of life. Transplantation is also the cheaper option for society. Living kidney donation raises the issue of the becoming of the donor, an absolutely healthy subject who gets to a surgical procedure. The becoming of living kidney donors has been compared with the one of controls subjects in several studies. The evaluations focused on the complications of nephrectomy in the short and long-term: kidney failure, hypertension, proteinuria, possibility of pregnancy, quality of life, and mortality...
October 11, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29030886/genetics-of-acute-rejection-after-kidney-transplantation
#7
REVIEW
Casey R Dorr, William S Oetting, Pamala A Jacobson, Ajay K Israni
Treatment of acute rejection (AR) following kidney transplantation has improved in recent years, but there are still limitations to successful outcomes. This review article covers literature in regards to recipient and donor genetics of AR kidney and secondarily of liver allografts. Many candidate gene and some genome wide association studies (GWAS) have been conducted for AR in kidney transplantation. Genetic associations with AR in kidney and liver are mostly weak and in most cases the associations have not been reproducible...
October 14, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29023314/renal-dysfunction-and-cirrhosis
#8
François Durand, Jody C Olson, Mitra K Nadim
PURPOSE OF REVIEW: Hepatorenal syndrome (HRS) does not represent the predominant phenotype of acute kidney injury (AKI) in cirrhosis. Early recognition of HRS helps initiate appropriate therapy. The aims of this review are to present redefinition of AKI, to list new biomarkers, to report recent data on vasopressors in HRS and to propose criteria for simultaneous liver and kidney transplantation (SLKT). RECENT FINDINGS: Urine output, which was not part of the definition of AKI might be reconsidered as it has an independent prognostic value...
October 11, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28988984/prevention-of-chronic-renal-allograft-rejection-by-as2553627-a-novel-jak-inhibitor-in-a-rat-transplantation-model
#9
Koji Nakamura, Yuka Kawato, Yoko Kaneko, Kaori Hanaoka, Kaori Kubo, Tomonori Nakanishi, Masashi Maeda, Hidehiko Fukahori, Misato Ito, Takahisa Noto, Masamichi Inami, Jun Hirose, Tatsuaki Morokata
BACKGROUND: Janus kinase (JAK) inhibitors are thought to be promising candidates to aid renal transplantation. However, the effectiveness of JAK inhibitors against features of chronic rejection, including interstitial fibrosis/tubular atrophy (IF/TA) and glomerulosclerosis, has not been elucidated. Here, we investigated the effect of AS2553627, a novel JAK inhibitor, on the development of chronic rejection in rat renal transplantation. METHODS: Lewis (LEW) to Brown Norway (BN) rat renal transplantation was performed...
October 5, 2017: Transplant Immunology
https://www.readbyqxmd.com/read/28983694/incomplete-vaccination-coverage-in-european-children-with-end-stage-kidney-disease-prior-to-renal-transplantation
#10
Britta Höcker, Martin Aguilar, Paul Schnitzler, Lars Pape, Luca Dello Strologo, Nicholas J A Webb, Martin Bald, Gurkan Genc, Heiko Billing, Jens König, Anja Büscher, Markus J Kemper, Stephen D Marks, Martin Pohl, Marianne Wigger, Rezan Topaloglu, Susanne Rieger, Kai Krupka, Thomas Bruckner, Alexander Fichtner, Burkhard Tönshoff
BACKGROUND: Because infections constitute a major cause of morbidity and mortality in paediatric renal allograft recipients, avoidance of preventable systemic infections by vaccination before transplantation is of utmost importance. However, data on the completeness of vaccinations and factors associated with incomplete vaccination coverage are scarce. METHODS: Within the framework of the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN), we therefore performed a multi-centre, multi-national, retrospective study investigating the vaccination coverage before transplantation of 254 European children with end-stage renal disease (mean age 10...
October 5, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28979776/usefulness-of-99m-tc-dimercaptosuccinic-acid-renal-scan-in-the-diagnosis-and-follow-up-of-acute-tubulointerstitial-nephritis-in-children
#11
Enrico Vidal, Elisabetta Miorin, Pietro Zucchetta, Elisa Benetti, Germana Longo, Davide Meneghesso, Mattia Parolin, Luisa Murer
BACKGROUND: Symptoms and signs of acute tubulointerstitial nephritis (ATIN) are nonspecific; therefore, renal biopsy is often necessary to clarify the diagnosis. The aim of this study was to evaluate the use of (99m)Tc-dimercaptosuccinic acid (DMSA) scintigraphy in the diagnosis and follow-up of ATIN. METHODS: We retrospectively reviewed the charts of five patients (nine renal units) with a median age of 14 years who underwent DMSA scan after a clinical and/or biopsy-proven diagnosis of ATIN...
October 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28964472/organ-allocation-and-utilization-in-pediatric-transplantation
#12
Walter S Andrews, Bartholomew J Kane, Richard J Hendrickson
Pediatric transplant candidates include heart, lung, liver, pancreas, small intestine, and kidney. The purpose of this article is to review the history and current methods for determining priority of the above-mentioned transplantable organs. The methods used by the authors involved the review of historical and current manuscripts and UNOS policy documents. We summarized the findings in order to create a concise review of the current policies and wait times for transplantation in pediatric transplant patients...
August 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/28951777/hepatitis-b-in-renal-transplant-patients
#13
REVIEW
Smaragdi Marinaki, Kyriaki Kolovou, Stratigoula Sakellariou, John N Boletis, Ioanna K Delladetsima
Hepatitis B virus (HBV) poses a significant challenge for both dialysis patients and kidney transplant recipients despite its decreasing rates, especially in developed countries. The best preventive method is vaccination. Patients with chronic renal disease should ideally be vaccinated prior to dialysis, otherwise, reinforced vaccination practices and close antibody titer monitoring should be applied while on dialysis. HBV infected dialysis patients who are renal transplant candidates must be thoroughly examined by HBV-DNA, and liver enzyme testing and by liver biopsy...
September 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28947546/effect-of-organ-donation-after-circulatory-determination-of-death-on-number-of-organ-transplants-from-donors-with-neurologic-determination-of-death
#14
Vivek Rao, Sonny Dhanani, Janet MacLean, Clare Payne, Elizabeth Paltser, Atul Humar, Jeffrey Zaltzman
BACKGROUND: To increase the available pool of organ donors, Ontario introduced donation after circulatory determination of death (DCD) in 2006. Other jurisdictions have reported a decrease in donations involving neurologic determination of death (NDD) after implementation of DCD, with a drop in organ yield and quality. In this study, we examined the effect of DCD on overall transplant activity in Ontario. METHODS: We examined deceased donor and organ transplant activity during 3 distinct 4-year eras: pre-DCD (2002/03 to 2005/06), early DCD (2006/07 to 2009/10) and recent DCD (2010/11 to 2013/14)...
September 25, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28947279/kidney-allocation-based-on-proven-acceptable-antigens-results-in-superior-graft-survival-in-highly-sensitized-patients
#15
Sebastiaan Heidt, Geert W Haasnoot, Jon J van Rood, Marian D Witvliet, Frans H J Claas
Highly sensitized renal transplant candidates accumulate on transplant waiting lists since they produce antibodies to many HLA antigens, which in this way become unacceptable. Organ allocation to these patients is usually based on avoiding transplantation of organs bearing these unacceptable antigens. In contrast, allocation through the Eurotransplant Acceptable Mismatch (AM) program is based on extension of the patient's own HLA type with so-called acceptable HLA antigens to which strictly no antibodies are formed, as shown by extensive laboratory testing...
September 22, 2017: Kidney International
https://www.readbyqxmd.com/read/28925596/a-kidney-offer-acceptance-decision-tool-to-inform-the-decision-to-accept-an-offer-or-wait-for-a-better-kidney
#16
Andrew Wey, Nicholas Salkowski, Walter K Kremers, Cory R Schaffhausen, Bertram L Kasiske, Ajay K Israni, Jon J Snyder
We developed a kidney offer acceptance decision tool to predict the probability of graft survival and patient survival for first-time kidney-alone candidates after an offer is accepted or declined, and we characterized the effect of restricting the donor pool with a maximum acceptable kidney donor profile index (KDPI). For accepted offers, Cox proportional hazards models estimated these probabilities using transplanted kidneys. For declined offers, these probabilities were estimated by considering the experience of similar candidates who declined offers and the probability that declining would lead to these outcomes...
September 19, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28921746/identification-of-occult-active-infection-using-pet-ct-in-a-combined-liver-kidney-transplant-candidate
#17
Julien Al Shakarchi, Desley Neil, Graham Lipkin, Ahmed Elsharkawy, Nicholas Inston
This case describes a patient being considered for combined liver-kidney transplantation for Caroli's disease with a failed renal transplant. A chronic septic focus could not be located with standard imaging techniques, such as ultrasonography and computed tomography. This case report highlights the observation that a retained non-functioning transplant can be the cause of fever of unknown origin and PET-CT can be useful in diagnosing these challenging cases. This article is protected by copyright. All rights reserved...
September 16, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28918445/pre-emptive-intestinal-transplant-the-surgeon-s-point-of-view
#18
REVIEW
Augusto Lauro, Ignazio R Marino, Kishore R Iyer
Pre-emptive transplantation is a well-established practice for certain types of end-organ failure such as in the use of kidney transplantation. For irreversible intestinal failure, total parenteral nutrition (TPN) remains the gold standard, due to the suboptimal long-term results of intestinal transplantation. As such, the only role for pre-emptive transplantation, if at all, will be for patients identified to be at high risk of complications and mortality while on definitive long-term TPN. In these patients, the timing of early listing and transplantation could become life-saving, taking into account that mortality on the waiting list is still the highest for intestinal candidates...
November 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28917674/prognostic-value-of-risk-factors-calcium%C3%A2-score-coronary-cta-myocardial%C3%A2-perfusion-imaging-and-invasive%C3%A2-coronary-angiography-in-kidney%C3%A2-transplantation-candidates
#19
Simon Winther, My Svensson, Hanne Skou Jørgensen, Laust Dupont Rasmussen, Niels Ramsing Holm, Lars Christian Gormsen, Kirsten Bouchelouche, Hans Erik Bøtker, Per Ivarsen, Morten Bøttcher
OBJECTIVES: This study sought to perform a prospective head-to-head comparison of the predictive value of clinical risk factors and a variety of cardiac imaging modalities including coronary artery calcium score (CACS), coronary computed tomography angiography (CTA), single-photon emission computed tomography (SPECT), and invasive coronary angiography (ICA) on major adverse cardiac events (MACE) and all-cause mortality in kidney transplantation candidates. BACKGROUND: Current guidelines recommend screening for coronary artery disease in kidney transplantation candidates...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28892567/using-omics-to-explore-complications-of-kidney-transplantation
#20
REVIEW
Caragh P Stapleton, Peter J Conlon, Paul J Phelan
The importance of genetic and biochemical variation in renal transplant outcomes has been clear since the discovery of the HLA in the 1950s. Since that time, there have been huge advancements in both transplantation and omics. In recent years, there has seen an increased number of genome-, proteome- and transcriptome-wide studies in the field of transplantation moving away from the earlier candidate gene/protein approaches. These areas have the potential to lead to the development of personalized treatment depending on individual molecular risk profiles...
September 11, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
keyword
keyword
18344
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"