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Kidney transplant candidate

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https://www.readbyqxmd.com/read/27899225/humoral-and-cellular-response-after-varicella-vaccination-in-vzv-igg-seronegative-kidney-transplant-candidates
#1
Marcia M L Kho, Joke M Zuijderwijk, Annemiek A van der Eijk, Ronella de Kuiper, Marieken J Boer-Verschragen, Willem Weimar, Nicole M van Besouw
BACKGROUND: In immunocompromised patients, primary infection with VZV may have a disastrous clinical course. Vaccination of VZV-seronegative patients on the waiting list for renal transplantation may prevent severe disease. However, the immunologic response of end-stage renal disease patients to peptide vaccines is far from optimal. Our question was whether end-stage renal disease patients with undetectable VZV-IgG levels were able to mount an adequate humoral and cellular response to a live attenuated varicella vaccine...
November 26, 2016: Vaccine
https://www.readbyqxmd.com/read/27890719/casting-a-smaller-net-into-a-bigger-donor-pool-a-single-center-s-experience-with-the-new-kidney-allocation-system
#2
Julie A Houp, Karl P Schillinger, Andrew J Eckstein, Renato M Vega, Niraj M Desai, Bonnie E Lonze, Annette M Jackson
The new Kidney Allocation System (KAS) provides additional allocation points for candidates with broad HLA sensitization in an effort to increase transplant rates for this underserved population. Following the implementation of KAS, our center lowered the HLA antibody threshold for listing unacceptable antigens from a cytotoxicity crossmatch level to a flow cytometric crossmatch level increasing Calculated Panel Reactive Antibody (CPRA) values and allocation points, yet restricting acceptable donor HLA phenotypes...
November 24, 2016: Human Immunology
https://www.readbyqxmd.com/read/27888276/communicating-about-choices-in-transplantation-coach-results-of-a-pilot-test-using-matched-controls
#3
Heather M Traino, Stacy M West, Camilla W Nonterah, Jennifer Russell, Eva Yuen
INTRODUCTION: Previous research highlights the difficulties patients with end-stage renal disease awaiting kidney transplant experience while attempting to manage both the logistical and the content-related aspects of discussions about transplantation. This article presents pilot results of the behavioral communication intervention program, Communicating about Choices in Transplantation (COACH), designed to improve transplant candidates' communication about transplantation. RESEARCH QUESTIONS: As compared to matched controls, increases in knowledge of deceased and living donor transplantation, communication self-efficacy, intentions to hold conversations about transplantation, and self-reported discussion were expected for pilot participants from pre- and postassessment; decreases in conversational difficulties were also posited...
November 25, 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27816867/effectiveness-of-weight-loss-intervention-in-highly-motivated-people
#4
Mariétou H Ouayogodé
A variety of approaches have been implemented to address the rising obesity epidemic, with limited success. I consider the success of weight loss efforts among a group of highly motivated people: those required to lose weight in order to qualify for a life-saving kidney transplantation. Out of 246 transplantation centers, I identified 156 (63%) with explicit body mass index (BMI) requirements for transplantation, ranging from 30 to 50kg/m(2). Using the United States national registry of transplant candidates, I examine outcomes for 29,608 obese deceased-donor transplant recipients between 1990 and 2010...
October 17, 2016: Economics and Human Biology
https://www.readbyqxmd.com/read/27805523/smoking-behaviors-of-renal-transplant-recipients-an-analysis-of-113-patients
#5
Fisun Sözen, Sinem Aydemir, Rengin Erdal, Mehmet Haberal
OBJECTIVES: Smoking is the most important remediable risk factor for the progression of renal diseases. Smoking has serious adverse effects, such as cardiovascular disease, kidney function impairment, and cancer in kidney transplant recipients who are already at high risk for these diseases. In this study, our objective was to evaluate descriptive characteristics and smoking status of renal transplant recipients. MATERIALS AND METHODS: We evaluated 113 patients who underwent renal transplant at Baskent University Hospital between 1990 and 2015...
November 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27805516/pretransplant-thyroid-findings-in-patients-with-end-stage-renal-disease
#6
Eda Yılmaz Akçay, Merih Tepeoğlu, Binnaz Handan Özdemir, Gonca Özgün, Semih Kazancı, Mehmet Haberal
OBJECTIVES: Patients with end-stage renal diseases can display abnormal thyroid gland function due to altered hormone excretion and transport. In this study, we aimed to evaluate the incidence of thyroid diseases by fine-needle aspiration cytology in kidney transplant candidates and to estimate the outcomes of these patients. MATERIALS AND METHODS: We reevaluated thyroid fineneedle aspiration biopsies, which were performed between January 2000 and December 2015, of 181 candidates for kidney transplant...
November 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27805305/the-impact-of-the-new-kidney-allocation-system-kas-on-prior-living-kidney-donors-access-to-deceased-donor-kidney-transplants-an-early-look
#7
J L Wainright, A Y Kucheryavaya, D K Klassen, D E Stewart
This study investigated the early effects of the new Kidney Allocation System (KAS) on prior living kidney donors' (PLDs) access to deceased donor kidney transplants. Using OPTN data, we compared prevalent and incident cohorts of PLDs in the 1-year periods before and after KAS (pre-KAS: 12/4/13-12/3/14, n=50 newly listed; post-KAS: 12/4/14-12/3/15, n=39). We assessed transplant rates per active patient-year, waiting times, and the Kidney Donor Profile Index (KDPI) of transplanted kidneys. Transplant rates were not statistically different pre vs...
November 2, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27799969/bk-viremia-among-iranian-renal-transplant-candidates
#8
Manizheh Jozpanahi, Amitis Ramezani, Shahrzad Ossareh, Mohammad Banifazl, Anahita Bavand, Setareh Mamishi, Arezoo Aghakhani
BACKGROUND: Primary infection with BK virus (BKV) is occurred during childhood and usually asymptomatic, but after initial infection, BKV may persist lifelong in the kidney and genitourinary tract. Reactivation may occur in individuals with compromised immunity such as renal transplant recipients. Due to the role of BKV in BK virus-associated nephropathy (BKVAN) and potentially renal allograft rejection, the detection of BKV in renal transplant candidates is very important. The aim of this study was to evaluate the frequency of BK viremia in end stage renal disease cases who were candidates for renal transplantation...
2016: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/27779800/the-expanded-criteria-donor-for-kidney-transplant-not-a-nearly-new-car
#9
Johan De Meester
From late nineteen nineties, the higher number of suitable renal transplant candidates has forced the transplant community to re-explore the whole spectrum of deceased donors after brain death (DBD) as well as after cardiac death (DCD); in practice, donors of older age and donors with more chronic diseases or "medical complexities". This new kidney donor population - finally defined as extended criteria donors (ECD) - currently comprises on average 20 to 25%. In his seminal paper in 2003 on the introduction of ECD in the US, Metzger et al...
October 25, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27773831/kidney-transplantation-of-highly-sensitized-recipients-under-the-new-kidney-allocation-system-a-reflection-from-five-different-transplant-centers-across-the-united-states
#10
Ronald F Parsons, Jayme E Locke, Robert R Redfield, Garrett R Roll, Matthew H Levine
Deceased donor kidney allocation was reorganized in the United States to address several problems, including the highly sensitized patients disadvantaged with large, diverse repertoires of antibodies. Here, five transplant surgeons review their center's experience with the new allocation changes: highlighting areas of accomplishment, opportunities for improvement and, in some cases, stark differences in practice. Across these five centers the highly sensitized patients (CPRA ⩾98%) range from 5.5 to 9.2% of the 12,364 candidates on their collective waitlist...
October 20, 2016: Human Immunology
https://www.readbyqxmd.com/read/27771385/should-epitope-based-hla-compatibility-be-used-in-the-kidney-allocation-system
#11
Rene J Duquesnoy
The new kidney allocation system (KAS) still applies donor-recipient HLA compatibility mostly at the antigen level and although some four-digit alleles have been included. This system is used to record unacceptable mismatches for sensitized transplant candidates with serum HLA antibodies. Since the reactivities of such antibodies are specifically associated with epitopes rather than HLA antigens, a more scientifically accurate assessment of mismatch acceptability could be based on epitopes. HLA class I and class II epitope specificity analyses can now be readily performed with serum antibody assays with single allele panels...
October 19, 2016: Human Immunology
https://www.readbyqxmd.com/read/27771384/the-new-kidney-allocation-system-does-not-equally-advantage-all-very-high-cpra-candidates-a-single-center-analysis
#12
Amy B Hahn, Maryanne Mackey, Don Constantino, Ashar Ata, Nikolaos Chandolias, Reynold Lopez-Soler, David J Conti
The new UNOS kidney allocation system awards very high points to candidates with cPRA 99% and 100%, and allows for national sharing for cPRA 100% candidates. We sought to determine the effect of this new kidney allocation system on candidates who are very highly sensitized (90-98% cPRA) but not eligible for very high points or national sharing by examining offers to these candidates for 5months pre-implementation and two consecutive 5month periods post-implementation and comparing them to cPRA⩾99% candidates...
October 19, 2016: Human Immunology
https://www.readbyqxmd.com/read/27768693/a-comparison-of-different-algorithms-for-the-assessment-of-cardiovascular-risk-in-patients-at-waiting-list-for-kidney-transplantation
#13
Stefan Reuter, Stefanie Reiermann, Viola Malyar, Katharina Schütte-Nütgen, Renè Schmidt, Hermann Pavenstädt, Holger Reinecke, Barbara Suwelack
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death after renal transplantation with a high prevalence in dialysis patients. It is still a matter of debate how to assess the cardiovascular risk in kidney transplant candidates. Several approaches and scores exist and found their way into the guidelines. METHODS AND RESULTS: We herein assessed PROCAM, Framingham, ESC-SCORE and our own dedicated algorithm in patients applying for renal transplantation at our transplantation center between July 2006 and August 2009...
2016: PloS One
https://www.readbyqxmd.com/read/27768622/survival-benefit-of-kidney-transplantation-in-hiv-infected-patients
#14
Jayme E Locke, Sally Gustafson, Shikha Mehta, Rhiannon D Reed, Brittany Shelton, Paul A MacLennan, Christine Durand, Jon Snyder, Nicholas Salkowski, Allan Massie, Deirdre Sawinski, Dorry L Segev
OBJECTIVE: To determine the survival benefit of kidney transplantation in human immunodeficiency virus (HIV)-infected patients with end-stage renal disease (ESRD). SUMMARY BACKGROUND DATA: Although kidney transplantation (KT) has emerged as a viable option for select HIV-infected patients, concerns have been raised that risks of KT in HIV-infected patients are higher than those in their HIV-negative counterparts. Despite these increased risks, KT may provide survival benefit for the HIV-infected patient with ESRD, yet this important clinical question remains unanswered...
April 26, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27759741/acute-kidney-injury-in-liver-transplant-candidates-a-position-paper-on-behalf-of-the-liver-intensive-care-group-of-europe
#15
Paolo Angeli, Dimitri Bezinover, Gianni Biancofiore, Anja Bienholz, James Findlay, Catherine Paugam Burtz, Koen Reyntjens, Tetsuro Sakai, Fuat H Saner, Dana Tomescu, Gebhard Wagener, Emmanuel Weiss
Acute kidney injury (AKI) is associated with high perioperative mortality. A series of AKI research breakthroughs are worth mentioning. First, in 2003, serum and urine biomarkers specific to AKI were identified. These biomarkers have contributed to early detection, prevention, and treatment of AKI. In 2004, AKI severity was defined with the Risk, Injury, Failure, Loss, and End-stage kidney disease (RIFLE) criteria, which was developed by the International Consensus Conference Workgroup of the Acute Dialysis Quality Initiative...
October 19, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27757587/poor-outcomes-for-children-on-the-wait-list-at-low-volume-kidney-transplant-centers-in-the-united-states
#16
Abbas Rana, Eileen D Brewer, Brandi B Scully, Michael L Kueht, Matt Goss, Karim J Halazun, Hao Liu, N Thao N Galvan, Ronald T Cotton, Christine A O'Mahony
BACKGROUND: Low case volume has been associated with worse survival outcomes in solid organ transplantation. Our aim was to analyze wait-list outcomes in conjunction with posttransplant outcomes. METHODS: We studied a cohort of 11,488 candidates waitlisted in the Organ Procurement and Transplantation Network (OPTN) for pediatric kidney transplant between 2002 and 2014, including both deceased- and living-donor transplants; 8757 (76 %) candidates received a transplant...
October 18, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27752472/hiv-infection-with-viro-immunological-dissociation-in-a-patient-with-polycystic-kidney-disease-candidate-for-transplantation
#17
Claudia Colomba, Marcello Trizzino, Claudia Gioè, Danilo Di Bona, Alessandra Mularoni, Antonio Cascio
Here we describe the case of a HIV-infected patient with polycystic kidney disease and end stage renal diseases not transplantable due to the persistence of a CD4 count <200 notwithstanding a good virological response to highly active antiretroviral therapy and suggest that such limitation to kidney transplantation in such as cases might be bypassed.
2016: IDCases
https://www.readbyqxmd.com/read/27743878/the-coordination-of-allocation-logistics-of-kidney-organ-allocation-to-highly-sensitized-patients
#18
John Lunz, Lisa Hinsdale, Casey King, Robin Pastush, Magnolia Buenvenida, Michael Harmon
Since implementation, the new UNOS OPTN kidney allocation system (KAS) has drastically expanded the pool of available kidneys to candidates that may have previously waited extended periods for an organ offer. This is particularly true for highly sensitized patients. The changes to the KAS have had ramifications throughout the transplant process, including for organ procurement organizations (OPO) and local transplant hospital call centers. Here, we will examine the impact of the new KAS on the organ donation process and highlight the necessary interactions between the OPO and transplant centers to best match donor kidneys and highly sensitized recipients...
October 12, 2016: Human Immunology
https://www.readbyqxmd.com/read/27742389/do-federal-regulations-have-an-impact-on-kidney-transplant-outcomes
#19
Kenneth J Woodside, Randall S Sung
Transplantation is one of the most highly regulated fields in health care. An important component of transplant oversight is the performance assessment of transplant centers as measured by 1-year patient and graft survival outcomes. The use of the Organ Procurement and Transplantation Network and Scientific Registry of Transplant Recipients flagging mechanism for quality improvement as criteria for Center for Medicare and Medicaid Services certification has resulted in greater importance in transplant program operations...
September 2016: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/27742323/positive-rates-of-preliminary-crossmatches-among-transplantation-candidates-waitlisted-for-different-organs-in-the-korean-network-for-organ-sharing
#20
M H Park, S Kim, H Hwang, H Park, J Kwak, E K Kwon, H Y Sung, B Han
OBJECTIVE: For deceased-donor organ transplantations, negative T cell crossmatches (XMs) are mandatory for kidney and pancreas allocation in the Korean Network for Organ Sharing (KONOS) organ allocation system. Submission and periodic renewal of serum to the KONOS is required for all transplantation candidates of kidney or pancreas and these sera are distributed to 23 laboratories for preliminary XMs. We have investigated how sensitization status varies among transplantation candidates waitlisted for different organs...
September 2016: Transplantation Proceedings
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