Becky M Ma, Naama Elefant, Martina Tedesco, Kelsie Bogyo, Natalie Vena, Sarath K Murthy, Shiraz A Bheda, Sandy Yang, Nikita Tomar, Jun Y Zhang, Syed Ali Husain, Sumit Mohan, Krzysztof Kiryluk, Hila Milo Rasouly, Ali G Gharavi
Cardiovascular disease, infection, malignancy, and thromboembolism are major causes of morbidity and mortality in kidney transplant recipients (KTR). Prospectively identifying monogenic conditions associated with post-transplant complications may enable personalized management. Therefore, we developed a transplant morbidity panel (355 genes) associated with major post-transplant complications including cardiometabolic disorders, immunodeficiency, malignancy, and thrombophilia. This gene panel was then evaluated using exome sequencing data from 1590 KTR...
March 21, 2024: Kidney International