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https://www.readbyqxmd.com/read/27924757/cardiac-resynchronization-therapy-prevents-progression-of-renal-failure-in-heart-failure-patients
#1
Vinodh Jeevanantham, Mohit Turagam, David Shanberg, Madhu Reddy, Moustapha Atoui, James P Daubert, Buddhadeb Dawn, Dhanunjaya Lakkireddy
BACKGROUND: The goal of this study is to assess the effect of cardiac resynchronization therapy (CRT) over time on renal function and its impact on mortality. The effect of CRT on renal function in patients with heart failure is not well understood. METHODS: All patients who underwent CRT implantation at University of Kansas between year 2000 and 2009 were reviewed and patients who had pre and post CRT renal function studied were included in our study. Stages of chronic kidney disease (CKD) were defined based on Kidney Disease Outcome Quality Initiative (KDOQI) guidelines...
July 2016: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/27866375/pre-operative-assessment-for-arteriovenous-fistula-placement-for-dialysis
#2
REVIEW
Maria G Marques, Pedro Ponce
Native AV fistulas are considered to be the best VA for most dialysis patients. A careful preoperative process of care is essential to maximize the proportion of fistulas that achieve adequacy for dialysis. An individualized and timely evaluation of patients starts early with the identification of risk factors, followed by a physical examination which should be complemented by ultrasound vascular mapping in most cases. Vascular mapping includes any technique that leads to information on patient's inflow and outflow anatomy (± hemodynamics) as they relate to arteriovenous access creation and may predict maturation...
November 20, 2016: Seminars in Dialysis
https://www.readbyqxmd.com/read/27783256/predictive-factors-of-renal-toxicities-related-to-anti-vegfr-multikinase-inhibitors-in-phase-1-trials
#3
Emilie Boissier, Olivier Mir, Antoine Hollebecque, Hassan Izzedine, Stéphane Ederhy, Anas Gazzah, Rastislav Bahleda, Christophe Massard, Isabelle Macquin-Mavier, Christophe Tournigand, Jean-Philippe Spano, Jean-Charles Soria, Benoît Rousseau
Purpose Renal toxicities are common with angiogenesis multikinase inhibitors (AMKI), and can be limiting in phase I trials. Factors associated with such toxicities are poorly known. The aims of this exploratory study were to describe renovascular toxicities associated with AMKI, impact on drug development and to identify baseline parameters associated with the occurrence of renal toxicities in phase I trials. Methods Consecutive patients treated with AMKI in Gustave Roussy phase I unit between October 2005 and August 2013 were included...
October 25, 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27778533/quality-of-life-clinical-outcome-personality-and-coping-in-chronic-hemodialysis-patients
#4
Giuseppina D'Onofrio, Mariadelina Simeoni, Paolo Rizza, Mariarita Caroleo, Maria Capria, Giovanni Mazzitello, Tiziana Sacco, Elena Mazzuca, Maria Teresa Panzino, Annamaria Cerantonio, Cristina Segura-Garcia, Michele Andreucci, Pasquale De Fazio, Giorgio Fuiano
RATIONAL: Our aim was to investigate the quality of life (QoL) in 103 patients undergoing chronic hemodialysis (HD) in an integrated assessment of clinical, personological, and adaptation parameters, also in a non-urban context. OBJECTIVES: We collected data from all chronic HD patients attending four HD units. Clinical status was assessed by Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines and by Age-adjusted Charlson Comorbidity Index (ACCI). Patients completed the following questionnaires: Kidney Disease Quality of Life Short Form (KDQOL-SF), Pittsburgh Sleep Quality Index (PSQI)...
October 25, 2016: Renal Failure
https://www.readbyqxmd.com/read/27754086/os-19-09-bioelectrical-impedance-phase-angle-as-intradialytic-hypotension-predictor
#5
Vaidas Vicka, Laurynas Rimsevicius, Alvita Gincaite, Diana Sukackiene, Marius Miglinas
OBJECTIVE: Water balance and blood pressure (BP) alterations are strongly associated in haemodialysis (HD) patients. Aim of this study was to determine whether bioelectrical impedance analysis (BIA) parameters can be used as predictors of intradialytic hypotension (IDH). DESIGN AND METHOD: We conducted an observational study of chronic HD patients. BIA was measured before the HD procedure using InBody S10 (Biospace, Seoul, Korea) body composition analyzer. Intracellular water (ICW), extracellular water (ECW), total body water (TBW), ECW/TBW ratio and phase angle (PhA) were selected as markers of hydration state and thus possible predictors of IDH...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27680289/negative-relationship-between-erythropoietin-dose-and-blood-lead-level-in-patients-undergoing-maintenance-hemodialysis
#6
Wen-Hung Huang, Ching-Wei Hsu, Cheng-Hao Weng, Dan-Tzu Lin-Tan, Tzung-Hai Yen
The adverse effects of increased blood lead levels have been well discussed. Several antioxidant agents have been reported to offer protection from lead toxicity and to reduce blood lead levels (BLL). Given that erythropoietin (EPO) also has antioxidant properties, the aim of this cross-sectional study was to assess the role of EPO and other clinical variables on BLL in hemodialysis (HD) patients. We recruited 931 maintenance hemodialysis (MHD) patients who had undergone HD for at least 6 months and who had ever received blood lead level (BLL) study...
September 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27643011/os-19-09-bioelectrical-impedance-phase-angle-as-intradialytic-hypotension-predictor
#7
Vaidas Vicka, Laurynas Rimsevicius, Alvita Gincaite, Diana Sukackiene, Marius Miglinas
OBJECTIVE: Water balance and blood pressure (BP) alterations are strongly associated in haemodialysis (HD) patients. Aim of this study was to determine whether bioelectrical impedance analysis (BIA) parameters can be used as predictors of intradialytic hypotension (IDH). DESIGN AND METHOD: We conducted an observational study of chronic HD patients. BIA was measured before the HD procedure using InBody S10 (Biospace, Seoul, Korea) body composition analyzer. Intracellular water (ICW), extracellular water (ECW), total body water (TBW), ECW/TBW ratio and phase angle (PhA) were selected as markers of hydration state and thus possible predictors of IDH...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27638233/progression-of-renal-impairment-and-chronic-kidney-disease-in-chronic-heart-failure
#8
Kevin Damman, Serge Masson, Donata Lucci, Marco Gorini, Renato Urso, Aldo P Maggioni, Luigi Tavazzi, Luigi Tarantini, Gianni Tognoni, Adriaan Voors, Roberto Latini
BACKGROUND: Data on the natural change in renal function in patients with chronic heart failure (HF) is limited. METHODS AND RESULTS: Estimated glomerular filtration rate (eGFR) was assessed over 36 months in 6934 patients included in the GISSI-HF study. Association between baseline, changes in renal function and occurrence of Cardiovascular Death or HF hospitalization was assessed. Mean age was 67 years, mainly males (78%) and mean eGFR was 68 mL/min/1.73m(2). Change in eGFR in the first year was -1...
September 13, 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27626266/-alternative-variants-of-formation-of-permanent-vascular-access-for-hemodialysis
#9
V A Batrashov, É N Manafov
A native arteriovenous fistula is the most preferred type of a permanent vascular access (PVA) amongst the patients on programmed haemodialysis. Complications of vascular accesses leading to their lost with time would eventually and unavoidably result in exhaustion of the vascular recourses of the patient thus creating posing a problem while forming yet another PVA. Taking into consideration vitally important necessity of carrying out haemodialysis procedures for these patients, vascular surgeons have to search for alternative variants of access to the vascular bed...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27588942/effectiveness-of-cinacalcet-in-patients-with-chronic-kidney-disease-and-secondary-hyperparathyroidism-not-receiving-dialysis
#10
Ariadna Pérez-Ricart, Maria Galicia-Basart, Maria Alcalde-Rodrigo, Alfons Segarra-Medrano, Josep-Maria Suñé-Negre, José-Bruno Montoro-Ronsano
BACKGROUND: Secondary hyperparathyroidism (SHPT) is a common complication in chronic kidney disease (CKD) patients. Cinacalcet could be a therapeutic option although its use is controversial in patients not receiving dialysis. Thus, the aim of this study is to assess the effectiveness and safety of cinacalcet in patients with CKD and SHPT without renal replacement treatment (RRT) and without renal transplantation (RT). METHODS: A retrospective observational study was conducted...
2016: PloS One
https://www.readbyqxmd.com/read/27519355/five-year-mortality-outcomes-in-patients-with-chronic-kidney-disease-undergoing-percutaneous-coronary-intervention
#11
Agam D Patel, Mohammed Ibrahim, Rajesh V Swaminathan, Irfan U Minhas, Luke K Kim, Prashanth Venkatesh, Dmitriy N Feldman, Robert M Minutello, Geoffrey W Bergman, S Chiu Wong, Harsimran S Singh
OBJECTIVE: To examine peri-procedural and long-term outcomes in patients with chronic kidney disease (CKD) undergoing percutaneous coronary interventions (PCI). BACKGROUND: Patients with advanced CKD are considered high risk when undergoing PCI. Limited published data exist on quantifying risk and assessment of long-term outcomes after PCI in this group. METHODS: Examining the Cornell Coronary Registry, we prospectively collected data of 6,478 consecutive patients who underwent elective or urgent PCI between 2009 and 2013...
August 13, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27508717/-op-1b-01-vitamin-k-dependent-protection-of-renal-function-in-multi-ethnic-population-studies
#12
F Wei, N E A Drummen, A E Schutte, L Thijs, L Jacobs, T Petit, W Y Yang, W Smith, Z Y Zhang, Y M Gu, T Kuznetsova, P Verhamme, K Allegaert, R Schutte, E Lerut, P Evenepoel, C Vermeer, J A Staessen
OBJECTIVE: Vitamin K (VK) dependent carboxylation of matrix Gla protein (MGP) protects the macrocirculation against calcification. Whether glomerular filtration (GFR), a renal microvascular trait, is related to circulating desphospho-uncarboxylated MGP (dp-ucMGP) has not been explored before. We therefore investigated our hypothesis in our Flemish Study on Environment, Genes and Health Outcomes (FLEMENGHO) and sought replication in the South African Study Regarding the Influence of Sex, Age and Ethnicity on Insulin Sensitivity and Cardiovascular Function (SAfrEIC)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27449697/ultrafiltration-rate-thresholds-in-maintenance-hemodialysis-an-nkf-kdoqi-controversies-report
#13
Holly Kramer, Jerry Yee, Daniel E Weiner, Vinod Bansal, Michael J Choi, Laura Brereton, Jeffrey S Berns, Milagros Samaniego-Picota, Paul Scheel, Michael Rocco
High hemodialysis ultrafiltration rate (UFR) is increasingly recognized as an important and modifiable risk factor for mortality among patients receiving maintenance hemodialysis. Recently, the Kidney Care Quality Alliance (KCQA) developed a UFR measure to assess dialysis unit care quality. The UFR measure was defined as UFR≥13mL/kg/h for patients with dialysis session length less than 240 minutes and was endorsed by the National Quality Forum as a quality measure in December 2015. Despite this, implementation of a UFR threshold remains controversial...
October 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27418390/test-of-the-recommended-dialysis-dose-on-one-year-mortality-of-nondiabetic-maintenance-hemodialysis-patients-observations-from-a-single-dialysis-unit
#14
Tuncay Sahutoglu, Ekrem Kara, Elbis Ahbap, Tamer Sakaci, Yener Koc, Taner Basturk, Mustafa Sevinc, Cuneyt Akgol, Zuhal Atan Ucar, Arzu Ozdemir Kayalar, Feyza Bayraktar Caglayan, Abdulkadir Unsal
BACKGROUND: The optimal delivered dialysis dose has been of a great interest for the last three decades, though a clear cut point has not been reached yet. We aimed to evaluate the relationship between one-year mortality and the delivered dialysis dose, which was recommended by Kidney Disease Outcomes Quality Initiative (KDOQI), in our maintenance hemodialysis (MHD) patients. METHODS: This was a single center, prospective observational study with one year of follow-up...
September 2016: Renal Failure
https://www.readbyqxmd.com/read/27366711/prevalence-and-severity-of-disordered-mineral-metabolism-in-patients-with-chronic-kidney-disease-a-study-from-a-tertiary-care-hospital-in-india
#15
Sanjay Vikrant, Anupam Parashar
BACKGROUND: Disordered mineral metabolism is common complications of chronic kidney disease (CKD). However, there are limited data on the pattern of these disturbances in Indian CKD population. MATERIALS AND METHODS: This was a prospective observational study of CKD-mineral and bone disorder (CKD-MBD) over a period of 3 years. The biochemical markers of CKD-MBD, namely, calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone (iPTH), and 25-hydoxyvitamin Vitamin D3 (25OHD), were measured in newly diagnosed CKD Stage 3-5 and prevalent CKD Stage 5D adult patients...
July 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27312146/pre-dialysis-decline-of-measured-glomerular-filtration-rate-but-not-serum-creatinine-based-estimated-glomerular-filtration-rate-is-a-risk-factor-for-mortality-on-dialysis
#16
Chava L Ramspek, Hakan Nacak, Merel van Diepen, Marjolijn van Buren, Raymond T Krediet, Joris I Rotmans, Friedo W Dekker
BACKGROUND: Monitoring of renal function is important in patients with chronic kidney disease progressing towards end-stage renal failure, both for timing the start of renal replacement therapy and for determining the prognosis on dialysis. Thus far, studies on associations between estimated glomerular filtration rate (eGFR) measurements in the pre-dialysis stage and mortality on dialysis have shown no or even inverse relations, which may result from the poor validity of serum creatinine-based estimation equations for renal function in pre-dialysis patients...
June 16, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27296523/a-modified-nontransposed-brachiobasilic-arteriovenous-fistula-versus-brachiocephalic-arteriovenous-fistula-for-maintenance-hemodialysis-access
#17
Dayong Hu, Changbin Li, Liping Sun, Chunyu Zhou, Xinhua Li, Zisheng Ai, Jie Tang, Ai Peng
OBJECTIVE: With the growing need for reliable and durable upper arm hemodialysis access, we sought to compare the performance of a novel modified nontransposed brachiobasilic arteriovenous fistula (mNT-BBAVF) with that of the more traditional brachiocephalic arteriovenous fistula (BCAVF). METHODS: Briefly, to construct an mNT-BBAVF, an incision is made on the ulnar side of the elbow. The brachial artery and basilic vein are then isolated, and a side-to-side anastomosis is performed without transposition of the basilic vein...
October 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27197101/-end-stage-renal-disease-lymphopenia-characterization-and-clinical-correlation
#18
José Luis Lepe-Zúñiga, Pedro Morales-Molina, Gabriela Alejandra García-Nandayapa
BACKGROUND: Patients with End Stage Renal Disease (ESRD), defined as those in Stage 5 of the Kidney Disease Outcome Quality Initiative (KDOQI) classification, have a number of acquired immune deficiencies secondary to the uremic stage, among them lymphopenia. In the present report, we retrospectively characterized the peripheral blood lymphocyte counts in a group of patients with ESRD and we related lymphopenia to their biochemical parameters and to the presence or absence of infections...
July 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27171479/non-medical-risk-factors-as-avoidable-determinants-of-excess-mortality-in-children-with-chronic-kidney-disease-a-prospective-cohort-study-in-nicaragua-a-model-low-income-country
#19
Giovanni Montini, Alberto Edefonti, Yajaira Silva Galán, Mabel Sandoval Díaz, Marta Medina Manzanarez, Giuseppina Marra, Fabio Robusto, Gianni Tognoni, Fabio Sereni
BACKGROUND: The widely recognized clinical and epidemiological relevance of the socioeconomic determinants of health-disease conditions is expected to be specifically critical in terms of chronic diseases in fragile populations in low-income countries. However, in the literature, there is a substantial gap between the attention directed towards the medical components of these problems and the actual adoption of strategies aimed at providing solutions for the associated socioeconomic determinants, especially in pediatric populations...
2016: PloS One
https://www.readbyqxmd.com/read/27068269/prevalence-of-chronic-kidney-disease-and-associated-factors-in-chinese-individuals-with-type-2-diabetes-cross-sectional-study
#20
Kaifeng Guo, Lei Zhang, Fangya Zhao, Junxi Lu, Pan Pan, Haoyong Yu, Yuqian Bao, Haibing Chen, Weiping Jia
AIMS: This cross-sectional study aimed to determine the prevalence and associated risk factors of chronic kidney disease (CKD) in Chinese type 2 diabetic patients. METHODS: A total of 3301 patients with type 2 diabetes were included in this study. Anthropometric parameters and biochemical indices were measured. The main outcome measures were detection of CKD, albuminuria and estimated glomerular filtration rate (eGFR). RESULTS: The prevalence of CKD and albuminuria in Shanghai Chinese type 2 diabetic patients was 27...
July 2016: Journal of Diabetes and its Complications
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