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HIV and cardiovascular

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https://www.readbyqxmd.com/read/27906007/what-happens-to-cardiovascular-system-behind-the-undetectable-level-of-hiv-viremia
#1
REVIEW
Gabriella d'Ettorre, Giancarlo Ceccarelli, Paolo Pavone, Pietro Vittozzi, Gabriella De Girolamo, Ivan Schietroma, Sara Serafino, Noemi Giustini, Vincenzo Vullo
Despite the combined antiretroviral therapy has improved the length and quality of life of HIV infected patients, the survival of these patients is always decreased compared with the general population. This is the consequence of non-infectious illnesses including cardio vascular diseases. In fact large studies have indicated an increased risk of coronary atherosclerotic disease, myocardial infarction even in HIV patients on cART. In HIV infected patients several factors may contribute to the pathogenesis of cardiovascular problems: life-style, metabolic parameters, genetic predisposition, viral factors, immune activation, chronic inflammation and side effects of antiretroviral therapy...
April 27, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27905840/combining-cell-and-gene-therapy-in-an-effort-to-eradicate-hiv
#2
Thor A Wagner
More than 30 million people are infected with HIV, and HIV remains the fifth leading cause of disability-adjusted life years worldwide. Antiretroviral therapy (ART) dramatically decreases mortality rate, but there are side effects, long-term toxicities, expenses, stigmas, and inconveniences associated with chronic treatment, and HIV-infected individuals on ART have an increased risk of malignancies, cardiovascular disease, neurologic disease, and shortened life expectancy. Therefore, a cure for HIV remains an important goal...
December 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27905351/-visualizing-research-lines-in-public-health-an-analysis-based-on-bibliometric-maps-applied-to-the-revista-espa%C3%A3-ola-de-salud-p%C3%A3%C2%BAblica-2006-2015
#3
Carmen Gálvez
OBJECTIVE: Identifying research lines is essential to understand the knowledge structure of a scientific domain. The aim of this study was to identify the main research topics of within the domain of public health, in the Revista Española de Saslud Pública during 2006-2015. METHODS: Original articles included in the Social Sciences Citation Index (SSCI) database, available online through the Web of Science (WoS), were selected. The analysis units used were the keywords, KeyWords Plus (KW+), extracted automatically by SSCI...
December 1, 2016: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/27899066/predictive-factors-for-unfavorable-outcomes-of-tuberculous-pericarditis-in-human-immunodeficiency-virus-uninfected-patients-in-an-intermediate-tuberculosis-burden-country
#4
In Young Jung, Young Goo Song, Jun Yong Choi, Moo Hyun Kim, Woo Yong Jeong, Dong Hyun Oh, Yong Chan Kim, Je Eun Song, Eun Jin Kim, Ji Un Lee, Su Jin Jeong, Nam Su Ku, June Myung Kim
BACKGROUND: In areas where Mycobacterium tuberculosis is endemic, tuberculosis is known to be the most common cause of pericarditis. However, the difficulty in diagnosis may lead to late complications such as constrictive pericarditis and increased mortality. Therefore, identification of patients at a high risk for poor prognosis, and prompt initiation of treatment are important in the outcome of TB pericarditis. The aim of this study is to identify the predictive factors for unfavorable outcomes of TB pericarditis in HIV-uninfected persons in an intermediate tuberculosis burden country...
November 29, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27892704/the-effects-of-a-16-week-aerobic-exercise-programme-on-cognitive-function-in-people-living-with-hiv
#5
Adam McDermott, Lilia Zaporojan, Patricia McNamara, Colin P Doherty, Janice Redmond, Cuisle Forde, John Gormley, Mikel Egaña, Colm Bergin
High levels of cardiovascular fitness and physical activity are associated with higher levels of cognitive function in people with HIV, thus, they may reduce the risk of developing HIV-associated neurocognitive disorder (HAND). This study aimed to investigate the effects of a 16-week aerobic exercise intervention on cognitive function in people with HIV. Eleven participants living with HIV were recruited into the study. Participants were randomised into either an exercise group (n = 5), that completed a 16-week aerobic exercise programme training, 3 times per week (2 supervised sessions and one unsupervised session) or a control group (n = 6) that received no intervention...
November 28, 2016: AIDS Care
https://www.readbyqxmd.com/read/27887644/copenhagen-comorbidity-in-hiv-infection-cocomo-study-a-study-protocol-for-a-longitudinal-non-interventional-assessment-of-non-aids-comorbidity-in-hiv-infection-in-denmark
#6
Andreas Ronit, Judith Haissman, Ditte Marie Kirkegaard-Klitbo, Thomas Skårup Kristensen, Anne-Mette Lebech, Thomas Benfield, Jan Gerstoft, Henrik Ullum, Lars Køber, Andreas Kjær, Klaus Kofoed, Jørgen Vestbo, Børge Nordestgaard, Jens Lundgren, Susanne Dam Nielsen
BACKGROUND: Modern combination antiretroviral therapy (cART) has improved survival for people living with HIV (PLWHIV). Non-AIDS comorbidities have replaced opportunistic infections as leading causes of mortality and morbidity, and are becoming a key health concern as this population continues to age. The aim of this study is to estimate the prevalence and incidence of non-AIDS comorbidity among PLWHIV in Denmark in the cART era and to determine risk factors contributing to the pathogenesis...
November 26, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27886790/cardiac-disease-associated-with-human-immunodeficiency-virus-infection
#7
REVIEW
Gerald S Bloomfield, Claudia Leung
Over the last 2 decades human immunodeficiency virus (HIV) infection has become a chronic disease requiring long-term management. Aging, antiretroviral therapy, chronic inflammation, and several other factors contribute to the increased risk of cardiovascular disease in patients infected with HIV. In low-income and middle-income countries where antiretroviral therapy access is limited, cardiac disease is most commonly related to opportunistic infections and end-stage manifestations of HIV/acquired immunodeficiency syndrome, including HIV-associated cardiomyopathy, pericarditis, and pulmonary arterial hypertension...
February 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/27886418/surviving-triple-trouble-synchronous-breast-and-cervical-cancer-hiv-infection-and-myocardial-infarction
#8
Antony G Thottian, Supriya Mallick, Bhanuprasad Venkatesulu, Ranjit Kumar, Kunhiparambath Haresh, Subhash Gupta, Daya Nand Sharma, Pramod Kumar Julka, Goura Kishor Rath
Breast and cervical cancer are the two most common cancers in female. However, owing to the contrasting risk factors, synchronous breast and cervical cancer has very rarely been reported. However, noncommunicable disease like cardiovascular disease and different infections has tended to make situations complicated because of complex interaction. In recent years, such cases are being seen frequently and their management is challenging. We report such a case of synchronous breast and cervical cancer complicated by HIV infection and myocardial infarction...
November 25, 2016: Breast Journal
https://www.readbyqxmd.com/read/27885058/association-between-human-immunodeficiency-virus-infection-and-arterial-stiffness-in-children
#9
Justin S Kuilder, Nikmah S Idris, Diederick E Grobbee, Michiel L Bots, Michael Mh Cheung, David Burgner, Nia Kurniati, Cuno Spm Uiterwaal
BACKGROUND: Human immunodeficiency virus infection (HIV) is associated with increased cardiovascular risk and adverse cardiovascular outcome in adults. Early recognition of changes in vascular properties might prove essential in cardiovascular prevention in HIV-infected patients. We investigated the relations between HIV infection and arterial stiffness in children. METHODS: This cross-sectional study included 51 HIV-infected and 52 healthy children (age 3.2-14...
November 24, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27878224/potential-drug-interactions-in-patients-given-antiretroviral-therapy
#10
Wendel Mombaque Dos Santos, Silvia Regina Secoli, Stela Maris de Mello Padoin
Objective: to investigate potential drug-drug interactions (PDDI) in patients with HIV infection on antiretroviral therapy. Methods: a cross-sectional study was conducted on 161 adults with HIV infection. Clinical, socio demographic, and antiretroviral treatment data were collected. To analyze the potential drug interactions, we used the software Micromedex(r). Statistical analysis was performed by binary logistic regression, with a p-value of ≤0.05 considered statistically significant...
November 21, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27875832/remediating-hiv-associated-neurocognitive-disorders-via-cognitive-training-a-perspective-on-neurocognitive-aging
#11
David E Vance, Shameka L Cody, Linda Moneyham
Over 50% of adults with HIV exhibit some form of HIV-associated neurocognitive disorder, ranging from mild asymptomatic neurocognitive impairment to HIV-associated dementia. As adults age with HIV and become susceptible to cardiovascular and metabolic comorbidities, the prevalence and severity of such neurocognitive disorders are likely to increase. With compromised renal and hepatic functioning often accompanying HIV, pharmaceutical interventions to address such neurocognitive disorders may not be the best strategy and are not without risks...
2017: Interdisciplinary Topics in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27875824/multimorbidity-and-burden-of-disease
#12
Todd T Brown, Giovanni Guaraldi
With effective antiretroviral therapy, HIV has become a chronic disease, and life expectancy among HIV-infected persons is approaching that of HIV-uninfected persons. Despite this success, epidemiologic evidence suggests that the burden of multiple aging-related diseases, including cardiovascular disease, liver disease, metabolic abnormalities, chronic kidney disease, cognitive dysfunction, and osteoporosis, is higher in HIV-infected persons compared to their HIV-uninfected peers. These comorbid diseases tend to cluster in a single person, leading to multimorbidity and polypharmacy...
2017: Interdisciplinary Topics in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27875822/cellular-senescence-immunosenescence-and-hiv
#13
Tamàs Fülöp, Georges Herbein, Andrea Cossarizza, Jacek M Witkowski, Eric Frost, Gilles Dupuis, Graham Pawelec, Anis Larbi
Aging is a complex biological process that leads to several physiological changes. Among these changes, the most striking are those involving the innate and adaptive parts of the immune system. Furthermore, these changes are associated with a low-grade inflammation called inflamm-aging, which is the result of several lifelong antigenic stimulations, including chronic viral infections such as cytomegalovirus. Immunosenescence, concomitantly with inflamm-aging, is considered as the leading cause of age-related diseases including cardiovascular, neurodegenerative and metabolic diseases, and cancer...
2017: Interdisciplinary Topics in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27875821/are-hiv-infected-older-adults-aging-differently
#14
Stephen E Karpiak, Richard Havlik
With increasing success in treating HIV, infected persons are living longer, and a new challenge has emerged - the need to understand how HIV-infected adults are aging. What are the similarities with typical aging and what are the unique aspects that may have resulted from HIV infection, interacting with characteristic life style factors and other comorbid conditions? Are specific diseases and conditions (comorbidities), typically seen as part of the aging process, occurring at accelerated rates or with higher frequency (accentuated) in HIV-infected adults? At this juncture, conclusions should be tentative...
2017: Interdisciplinary Topics in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27864732/impact-of-pharmaceutical-care-on-cardiovascular-risk-among-older-hiv-patients-on-antiretroviral-therapy
#15
Elza Aparecida Machado Domingues, Mónica Ferrit-Martín, Miguel Ángel Calleja-Hernández
Background Advances in the treatment of HIV infection have enabled better control of the disease, allowing patients to enjoy a longer life expectancy. However, the ageing of patients leads to an increased prevalence of cardiovascular disease. Various studies have found that pharmaceutical care results in better control of cardiovascular risk factors. Objective To measure the impact of pharmaceutical care on cardiovascular risk in patients older than 50 years receiving combination antiretroviral therapy. Setting Outpatient pharmacy service of a tertiary hospital, Spain...
November 18, 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27860212/alcohol-and-dietary-factors-associate-with-gut-integrity-and-inflammation-in-hiv-infected-adults
#16
A R Webel, A Sattar, N T Funderburg, B Kinley, C T Longenecker, D Labbato, Sm Khurshid Alam, G A McComsey
OBJECTIVES: HIV-infected adults have heightened monocyte activation and inflammation, at least partially as a consequence of altered gut integrity. The role of dietary factors in microbial translocation and inflammation and their downstream effect on markers of cardiovascular disease (CVD) have not been explored. Our purpose was to describe the longitudinal dietary patterns of HIV-infected adults, and to examine the relationship between dietary intake, gut integrity, inflammation and subclinical markers of CVD in HIV-infected adults...
November 9, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27853986/the-hidden-risk-incorporating-inflammation-and-hiv-serostatus-into-coronary-artery-disease-screening
#17
EDITORIAL
Gregory A Payne, Edgar Turner Overton
CAD is a well-established comorbidity associated with HIV infection. This association is in large part due to ongoing inflammation propagated by viremia and dysregulation of the immune system. Despite this knowledge, evidence to guide clinical management and screening for CAD among HIV-infected patients is lacking. The following editorial discusses recent evidence that HIV-infected patients with abnormal cardiovascular stress testing are more likely to undergo subsequent percutaneous coronary intervention. Importantly, the cardiovascular consequences of HIV infection and potential clinical implications are discussed...
November 16, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27837530/freeze-fracture-electron-microscopy-on-domains-in-lipid-mono-and-bilayer-on-nano-resolution-scale
#18
Brigitte Papahadjopoulos-Sternberg
Freeze-fracture electron microscopy (FFEM) as a cryofixation, replica, and transmission electron microscopy technique is unique in membrane bilayer and lipid monolayer research because it enables us to excess and visualize pattern such as domains in the hydrophobic center of lipid bilayer as well as the lipid/gas interface of lipid monolayer. Since one of the preparation steps of this technique includes fracturing the frozen sample and since during this fracturing process the fracture plane follows the area of weakest forces, these areas are exposed allowing us to explore pattern built up by lipids and/or intrinsic proteins but also initiated by peptides, drugs, and toxins reaching into these normally hard to access areas...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27835618/increased-glucose-transporter-1-expression-on-intermediate-monocytes-from-hiv-infected-women-with-subclinical-cardiovascular-disease
#19
Tiffany R Butterfield, David B Hanna, Robert C Kaplan, Jorge R Kizer, Helen G Durkin, Mary A Young, Marek J Nowicki, Phyllis C Tien, Elizabeth T Golub, Michelle A Floris-Moore, Kehmia Titanji, Margaret A Fischl, Sonya L Heath, Jefferey Martinson, Suzanne M Crowe, Clovis S Palmer, Alan L Landay, Joshua J Anzinger
OBJECTIVE: People living with HIV (PLWH) have chronic immune activation and increased cardiovascular disease (CVD) risk. Activation of monocytes and T lymphocytes causes up-regulation of glucose transporter-1 (GLUT1) for efficient function. PLWH have an increased percentage of GLUT1-expressing monocytes and T lymphocytes, but it is unclear if these cells are associated with CVD. We evaluated expression of GLUT1 and CD38 on monocyte and T lymphocyte populations from HIV-infected women with subclinical CVD...
November 9, 2016: AIDS
https://www.readbyqxmd.com/read/27833730/general-diseases-influence-on-peri-implantitis-development-a-systematic-review
#20
REVIEW
Zygimantas Guobis, Ingrida Pacauskiene, Inesa Astramskaite
OBJECTIVES: To systematically review the influence of systemic diseases or medications used in their treatment on the dental implant therapy success. MATERIAL AND METHODS: The search strategy was implemented on the National Library of Medicine database (MEDLINE) (Ovid) and EMBASE electronic databases between January 2006 and January 2016. Human studies with available English articles analysing the relationship between dental implant therapy success and systemic diseases, such as diabetes mellitus, AIDS/HIV, rheumatoid arthritis, osteoporosis, Crohn's disease, cardiovascular diseases, scleroderma, Sjögren's syndrome, lichen planus, ectodermal dysplasia, post-transplantation status, were included in present review according to the PRISMA guidelines...
July 2016: Journal of Oral & Maxillofacial Research
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