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HIV and coagulation

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https://www.readbyqxmd.com/read/27909114/conservative-treatment-of-chronic-subdural-hematoma-in-hiv-associated-thrombocytopenia-with-tranexamic-acid
#1
Raja K Kutty, Anil Kumar Peethambaran, Sunilkumar, M Anilkumar
Chronic subdural hematomas (CSDHs) and its management comprise a majority work in a neurosurgical specialty. The effectiveness of surgery is beyond doubt and sometimes even lifesaving in severe cases. However, the straightforward surgery is sometimes complicated by the associated comorbidities of the patient. Comorbidities in the form of coagulopathies secondary to chronic liver diseases, drugs (warfarin, ecosprin, clopidogrel), thrombocytopenia secondary to systemic illness are always a challenge to deal with in patients with CSDH...
December 1, 2016: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/27875823/biomarkers-and-clinical-indices-of-aging-with-hiv
#2
Kathleen V Fitch, Meghan Noonan Feldpausch, Sara E Dolan Looby
HIV infection may potentiate specific biomarkers that influence the development of premature clinical indices commonly associated with aging. Therefore, predicting mortality outcomes in people living with HIV is extremely important as this population ages. This chapter describes biomarkers associated with inflammation, coagulation, and immune activation in HIV, and reviews the association between specific biomarkers and the development of co-morbid conditions in individuals with HIV. Measures that incorporate specific biomarkers related to HIV infection, designed to predict mortality outcomes in individuals with HIV, are also discussed...
2017: Interdisciplinary Topics in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27824677/do-biomarkers-of-inflammation-monocyte-activation-and-altered-coagulation-explain-excess-mortality-between-hiv-infected-and-uninfected-people
#3
Kaku A So-Armah, Janet P Tate, Chung-Chou H Chang, Adeel A Butt, Mariana Gerschenson, Cynthia L Gibert, David Leaf, David Rimland, Maria C Rodriguez-Barradas, Matthew J Budoff, Jeffrey H Samet, Lewis H Kuller, Steven G Deeks, Kristina Crothers, Russell P Tracy, Heidi M Crane, Mohammad M Sajadi, Hilary A Tindle, Amy C Justice, Matthew S Freiberg
BACKGROUND: HIV infection and biomarkers of inflammation [measured by interleukin-6 (IL-6)], monocyte activation [soluble CD14 (sCD14)], and coagulation (D-dimer) are associated with morbidity and mortality. We hypothesized that these immunologic processes mediate (explain) some of the excess risk of mortality among HIV infected (HIV+) versus uninfected people independently of comorbid diseases. METHODS: Among 2350 (1521 HIV+) participants from the Veterans Aging Cohort Study Biomarker Cohort (VACS BC), we investigated whether the association between HIV and mortality was altered by adjustment for IL-6, sCD14, and D-dimer, accounting for confounders...
June 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27822257/co-infection-of-the-hepatitis-c-virus-with-other-blood-borne-and-hepatotropic-viruses-among-hemophilia-patients-in-poland
#4
Marta Kucharska, Malgorzata Inglot, Aleksandra Szymczak, Weronika Rymer, Malgorzata Zalewska, Krzysztof Malyszczak, Urszula Zaleska-Dorobisz, Malgorzata Kuliszkiewicz-Janus
BACKGROUND: The prevalence of HCV infection in people with hemophilia is substantially higher than that in the general population (63% - 98%). Multiple transfusions and substitutive therapy have also been linked to a high risk of HBV and HIV transmission. However, the prevalence of other blood-borne viral infections in this population is less well known. OBJECTIVES: This study aimed to assess the prevalence of co-infection with HBV and other blood-borne viruses in Polish HCV-infected hemophiliacs...
September 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27813318/bleeding-and-liver-transplantation-outcomes-in-haemophilia
#5
K D Mehta, M V Ragni
BACKGROUND: Hepatitis C is the major cause of end-stage liver disease and the major indication for orthotopic liver transplantation (OLTx) in individuals with haemophilia. AIM: To assess the epidemiology and outcomes of OLTx in U.S. haemophilia patients. METHODS: We investigated haemophilia liver transplant recipients between 1993 and 2012, using the Nationwide Inpatient Sample, identified by ICD9 code 50.59. RESULTS: Of the 11 267 (weighted n = 54 691) patients undergoing OLTx, 44 (0...
November 4, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27737952/initiation-of-antiretroviral-therapy-in-early-hiv-infection-reduces-but-does-not-abrogate-chronic-residual-inflammation
#6
Irini Sereti, Shelly J Krebs, Nittaya Phanuphak, James L Fletcher, Bonnie Slike, Suteeraporn Pinyakorn, Robert J O'Connell, Adam Rupert, Nicolas Chomont, Victor Valcour, Jerome H Kim, Merlin L Robb, Nelson L Michael, Daniel C Douek, Jintanat Ananworanich, Netanya S Utay
BACKGROUND:  Serious non-AIDS events cause substantial morbidity and mortality despite HIV suppression with antiretroviral therapy (ART). Biomarkers of inflammation, coagulation cascade activation, and fibrosis predict these end-organ events. We aimed to determine whether ART initiation during acute HIV infection would attenuate changes in these biomarker levels. METHODS:  Plasma samples were obtained from participants starting ART during acute HIV infection, chronic HIV infection, and HIV-uninfected participants, from Bangkok, Thailand...
October 12, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27719675/impact-of-hiv-infection-on-the-presentation-outcome-and-host-response-in-patients-admitted-to-the-intensive-care-unit-with-sepsis-a-case-control-study
#7
Maryse A Wiewel, Michaëla A Huson, Lonneke A van Vught, Arie J Hoogendijk, Peter M C Klein Klouwenberg, Janneke Horn, René Lutter, Olaf L Cremer, Marcus J Schultz, Marc J Bonten, Tom van der Poll
BACKGROUND: Sepsis is a prominent reason for intensive care unit (ICU) admission in patients with HIV. We aimed to investigate the impact of HIV infection on presentation, outcome and host response in sepsis. METHODS: We performed a prospective observational study in the ICUs of two tertiary hospitals. For the current analyses, we selected all patients diagnosed with sepsis within 24 hours after admission. Host response biomarkers were analyzed in a more homogeneous subgroup of admissions involving HIV-positive patients with pneumosepsis, matched to admissions of HIV-negative patients for age, gender and race...
October 10, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27704656/long-term-liver-related-morbidity-and-mortality-related-to-chronic-hepatitis-c-virus-infection-in-swedish-patients-with-inherited-bleeding-disorders
#8
M Holmström, A Nangarhari, J Öhman, A-S Duberg, A Majeed, S Aleman
INTRODUCTION: Hepatitis C virus (HCV) infection is common in patients with inherited bleeding disorders treated with clotting factor concentrates prior to the introduction of viral inactivation of these products. The long-term consequences of hepatitis C infection in Swedish patients are not fully understood. AIM: To examine the impact of HCV infection on liver-related morbidity and mortality in Swedish patients with inherited bleeding disorders. METHODS: We retrospectively collected data on 183 patients with inherited bleeding disorders infected with HCV who attended the Coagulation Unit at Karolinska University Hospital, Sweden...
November 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27703039/inflammatory-function-of-cx3cr1-cd8-t-cells-in-treated-hiv-infection-is-modulated-by-platelet-interactions
#9
Joseph C Mudd, Soumya Panigrahi, Benjamin Kyi, So Hee Moon, Maura M Manion, Souheil-Antoine Younes, Scott F Sieg, Nicholas T Funderburg, David A Zidar, Michael M Lederman, Michael L Freeman
Increases in inflammation, coagulation, and CD8 T cell numbers are associated with elevated cardiovascular disease (CVD) risk in antiretroviral therapy (ART)-treated HIV infection. Circulating memory CD8 T cells that express the vascular endothelium-homing receptor CX3CR1 (fractalkine receptor) are enriched in ART-treated HIV-infected subjects. Thrombin-activated receptor (PAR-1) expression is increased in ART-treated HIV-infected subjects and is particularly elevated on CX3CR1+ CD8 T cells, suggesting that these cells could interact with coagulation elements...
October 4, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27683822/cigarette-smoking-and-inflammation-monocyte-activation-and-coagulation-in-hiv-infected-individuals-on-antiretroviral-therapy-compared-to-uninfected-individuals
#10
Katherine W Kooij, Ferdinand W N M Wit, Thijs Booiman, Marc van der Valk, Maarten F Schim van der Loeff, Neeltje A Kootstra, Peter Reiss
Smoking may affect cardiovascular disease risk more strongly in HIV-infected compared to HIV-uninfected individuals. We hypothesized that an interaction at the level of the immune system may contribute to this increased risk. We assessed soluble markers of inflammation (high-sensitivity C-reactive protein [hsCRP]), immune activation (soluble [s]CD14 and sCD163) and coagulation (D-dimer) in HIV-infected and uninfected never, former and current smokers. Smoking was independently associated with higher hsCRP levels and lower sCD163 levels, and at borderline significance with higher sCD14 and D-dimer levels; we found no evidence of a differential effect of smoking in HIV-infected compared to uninfected individuals...
September 28, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27618139/significant-decrease-in-plasma-levels-of-d-dimer-interleukin-8-and-interleukin-12-after-a-12-month-treatment-with-rosuvastatin-in-hiv-infected-patients-under-antiretroviral-therapy
#11
Leonardo Calza, Vincenzo Colangeli, Eleonora Magistrelli, Ilaria Contadini, Isabella Bon, Maria Carla Re, Matteo Conti, Rita Mancini, Pierluigi Viale
OBJECTIVES: Statins have shown anti-inflammatory and immune-modulatory properties in both general and HIV-infected population, but their effect on plasma D-dimer levels is controversial and it has not been investigated to date in HIV-positive patients. The aim of our study was to assess the effect of rosuvastatin on D-dimer and other serum inflammation markers among these subjects. METHODS: Prospective, cohort study of HIV-1-infected adult patients receiving a stable combination antiretroviral therapy (cART), who started a lipid-lowering therapy with rosuvastatin (10 mg daily) and were followed up for at least 12 months...
October 14, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27568666/effects-of-first-line-anti-retroviral-therapy-on-blood-coagulation-parameters-of-hiv-infected-patients-attending-a-tertiary-hospital-at-abuja-nigeria
#12
I A Nasir, A Owolagba, A E Ahmad, M M Barma, P O Musa Po, M Bakare, Y Ibrahim, D O Amadu
BACKGROUND: Blood coagulation abnormalities are common in persons infected with the human immunodeficiency virus (HIV). However, few studies showed the association of these abnormalities with anti-retroviral therapy (ART). OBJECTIVE: This cross-sectional study investigated the effects of ART on blood coagulation parameters of patients infected with HIV attending HIV special clinics of the University of Abuja Teaching Hospital (UATH), Gwagwalada, Abuja, Nigeria. MATERIAL AND METHODS: A total of 191 patients comprising 128 HIV subjects on ART (test subjects) and 63 other HIV patients not on ART (control subjects) were included in the study...
August 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/27509250/marker-of-endothelial-dysfunction-asymmetric-dimethylarginine-is-elevated-in-hiv-infection-but-not-associated-with-sub-clinical-atherosclerosis
#13
Judith M Haissman, Anna K Haugaard, Andreas Knudsen, Ulrik S Kristoffersen, Ingebjørg Seljeflot, Karin K Pedersen, Anne-Mette Lebech, Philip Hasbak, Andreas Kjær, Sisse R Ostrowski, Jan Gerstoft, Marius Trøseid, Susanne D Nielsen
BACKGROUND: Cardiovascular disease (CVD) contributes to excess morbidity and mortality in HIV infection, and endothelial dysfunction may contribute to this pattern. We aimed to determine endothelial function in treated and untreated HIV-infected individuals and investigate potential associations with viral replication, immune activation, coagulation, platelet function, and subclinical atherosclerosis. METHODS: Asymmetric dimethylarginine (ADMA, marker of endothelial dysfunction) and soluble CD14 (sCD14, marker of monocyte activation) were measured in plasma from two previously established cross-sectional cohorts: Cohort A including 50 untreated and 50 anti-retroviral therapy (ART) treated HIV-infected individuals with previously assessed coagulation and platelet function, and Cohort B including 105 HIV-infected individuals on ART and 105 uninfected controls with previously assessed coronary artery calcium score (CACS), myocardial perfusion defects (MPD), and carotid intima-media thickness (cIMT)...
August 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27437222/study-of-basic-coagulation-parameters-among-hiv-patients-in-correlation-to-cd4-counts-and-art-status
#14
R Thulasi Raman, D Manimaran, Praveen Rachakatla, K Bharathi, Tameem Afroz, Radha Sagar
INTRODUCTION: HIV infection is known to cause coagulation abnormalities by various mechanism, especially during its late course. AIM: The objective of this study was to analyse platelet count, prothrombin time and activated partial thromboplastin time among HIV infected patients and to analyse these parameters with respect to their CD4 count and ART status. MATERIALS AND METHODS: A case control study was conducted with 120 HIV infected patients and 40 normal individuals...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27419814/anal-dysplasia-screening-and-treatment-in-a-southern-human-immunodeficiency-virus-clinic
#15
Wesley G Willeford, Luis Barroso, Jennifer Keller, Nora Fino, Laura H Bachmann
BACKGROUND: Persistent human papillomavirus infection in human immunodeficiency virus (HIV)-infected individuals has been strongly associated with anal squamous cell carcinoma. The incidence of anal squamous cell carcinoma continues to increase in this population despite advances in HIV therapy. There are few studies describing the prevalence of anal cancer precursors, treatment outcomes, and associated factors among HIV-infected populations in the southern United States. METHODS: A retrospective chart review was performed on 355 HIV-infected patients from a Southern HIV clinic who were 18 years or older and had received at least one anal Pap smear...
August 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27320416/treatment-of-anal-dysplasia-in-hiv-positive-men-who-have-sex-with-men-in-a-large-aids-reference-centre
#16
Nathalie Willems, Agnès Libois, Marcel Nkuize, Francesco Feoli, Marc Delforge, Stéphane DeWit
OBJECTIVES: Over the last few decades, incidence of anal cancer among HIV-positive men has been on the rise. In this context, programmes of screening and treatment of anal dysplasia which is a precursor of anal cancer have been developed. The aim of our study was to describe the efficiency, side effects and outcome of anal dysplasia treatment in a population of HIV-positive men who have sex with men (MSM). METHODS: We performed a retrospective study of HIV-positive MSM who received treatment for anal dysplasia between May 2010 and February 2014 in the Saint-Pierre University Hospital, Brussels...
June 16, 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/27314025/etiologic-agents-of-bacterial-sepsis-and-their-antibiotic-susceptibility-patterns-among-patients-living-with-human-immunodeficiency-virus-at-gondar-university-teaching-hospital-northwest-ethiopia
#17
Gelila Alebachew, Brhanu Teka, Mengistu Endris, Yitayal Shiferaw, Belay Tessema
Background. Bacterial sepsis is a major cause of illness in human immunodeficiency virus infected patients. There is scarce evidence about sepsis among HIV patients in Ethiopia. This study aimed to determine the etiologic agents of bacterial sepsis and their antibiotic susceptibility patterns among HIV infected patients. Methods. A cross-sectional study was carried out from March 1 to May 2, 2013. One hundred patients infected with HIV and suspected of having sepsis were included. Sociodemographic data were collected by interview and blood sample was aseptically collected from study participants...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27300170/maraviroc-intensification-improves-endothelial-function-in-abacavir-treated-patients-an-open-label-randomized-cross-over-pilot-study
#18
Maaike Krikke, Kiki Tesselaar, Joop E Arends, Julia Drylewicz, Sigrid A Otto, Steven F L van Lelyveld, Frank J L Visseren, Andy I M Hoepelman
BACKGROUND: The increased risk of abacavir in cardiovascular disease (CVD) in HIV-infected patients is still being debated. Maraviroc, a CCR5 blocker, has been shown to decrease immune activation and monocyte infiltration in atherosclerotic plaques in murine experiments. Therefore, we examined the effect of maraviroc intensification on flow-mediated dilatation (FMD) in abacavir-treated HIV-infected patients and its effect on immunological and inflammatory parameters. METHODS: A open-label prospective crossover study with a duration of 16 weeks: 8 weeks of intervention (maraviroc intensification) and 8 weeks of control (unchanged cART regimen)...
September 2016: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/27222628/seroprevalence-of-human-immunodeficiency-virus-hepatitis-b-virus-hepatitis-c-virus-and-syphilis-among-blood-donors-at-jigjiga-blood-bank-eastern-ethiopia
#19
Melese Abate, Tesfaye Wolde
BACKGROUND: Transfusion-transmissible infectious agents such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), and Syphilis are among the greatest threats to blood safety for recipients. They are also the leading causes of death and chronic and life-threatening abnormalities. METHODS: A retrospective analysis of consecutive blood donors' records covering the period between January 2010 and December 2014 was conducted to analyze for seroprevalence of HIV, HBV, HCV and syphilis among blood donors aged 17-65 years...
March 2016: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/27187749/systemic-inflammation-and-liver-damage-in-hiv-hepatitis-c-virus-coinfection
#20
K V Shmagel, E V Saidakova, N G Shmagel, L B Korolevskaya, V A Chereshnev, J Robinson, J-C Grivel, D C Douek, L Margolis, D D Anthony, M M Lederman
OBJECTIVES: Chronic hepatitis C virus (HCV) and HIV viral infections are characterized by systemic inflammation. Yet the relative levels, drivers and correlates of inflammation in these settings are not well defined. METHODS: Seventy-nine HIV-infected patients who had been receiving antiretroviral therapy (ART) for more than 2 years and who had suppressed plasma HIV levels (< 50 HIV-1 RNA copies/mL) were included in the study. Two patient groups, HCV-positive/HIV-positive and HCV-negative/HIV-positive, and a control group comprised of healthy volunteers (n = 20) were examined...
September 2016: HIV Medicine
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