keyword
https://read.qxmd.com/read/38352349/focused-ultrasound-blood-brain-barrier-opening-arrests-the-growth-and-formation-of-cerebral-cavernous-malformations
#21
Delaney G Fisher, Khadijeh A Sharifi, Ishaan M Shah, Catherine M Gorick, Victoria R Breza, Anna C Debski, Matthew R Hoch, Tanya Cruz, Joshua D Samuels, Jason P Sheehan, David Schlesinger, David Moore, John R Lukens, G Wilson Miller, Petr Tvrdik, Richard J Price
BACKGROUND: Cerebral cavernous malformations (CCM) are vascular lesions within the central nervous system, consisting of dilated and hemorrhage-prone capillaries. CCMs can cause debilitating neurological symptoms, and surgical excision or stereotactic radiosurgery are the only current treatment options. Meanwhile, transient blood-brain barrier opening (BBBO) with focused ultrasound (FUS) and microbubbles is now understood to exert potentially beneficial bioeffects, such as stimulation of neurogenesis and clearance of amyloid-β...
February 4, 2024: bioRxiv
https://read.qxmd.com/read/38351049/u-s-cereal-rye-winter-cover-crop-growth-database
#22
JOURNAL ARTICLE
Alexandra M Huddell, Resham Thapa, Guillermo S Marcillo, Lori J Abendroth, Victoria J Ackroyd, Shalamar D Armstrong, Gautam Asmita, Muthukumar V Bagavathiannan, Kipling S Balkcom, Andrea Basche, Shawn Beam, Kevin Bradley, Lucas Pecci Canisares, Heather Darby, Adam S Davis, Pratap Devkota, Warren A Dick, Jeffery A Evans, Wesley J Everman, Tauana Ferreira de Almeida, Michael L Flessner, Lisa M Fultz, Stefan Gailans, Masoud Hashemi, Joseph Haymaker, Matthew J Helmers, Nicholas Jordan, Thomas C Kaspar, Quirine M Ketterings, Eileen Kladivko, Alexandra Kravchenko, Eugene P Law, Lauren Lazaro, Ramon G Leon, Jeffrey Liebert, John Lindquist, Kristen Loria, Jodie M McVane, Jarrod O Miller, Michael J Mulvaney, Nsalambi V Nkongolo, Jason K Norsworthy, Binaya Parajuli, Christopher Pelzer, Cara Peterson, Hanna Poffenbarger, Pratima Poudel, Mark S Reiter, Matt Ruark, Matthew R Ryan, Spencer Samuelson, John E Sawyer, Sarah Seehaver, Lovreet S Shergill, Yogendra Raj Upadhyaya, Mark VanGessel, Ashley L Waggoner, John M Wallace, Samantha Wells, Charles White, Bethany Wolters, Alex Woodley, Rongzhong Ye, Eric Youngerman, Brian A Needelman, Steven B Mirsky
Winter cover crop performance metrics (i.e., vegetative biomass quantity and quality) affect ecosystem services provisions, but they vary widely due to differences in agronomic practices, soil properties, and climate. Cereal rye (Secale cereale) is the most common winter cover crop in the United States due to its winter hardiness, low seed cost, and high biomass production. We compiled data on cereal rye winter cover crop performance metrics, agronomic practices, and soil properties across the eastern half of the United States...
February 13, 2024: Scientific Data
https://read.qxmd.com/read/38314881/the-role-of-temperature-wind-speed-and-precipitation-on-the-abundance-of-culex-species-and-west-nile-virus-infection-rate-in-rural-west-central-illinois
#23
JOURNAL ARTICLE
Michele M Rehbein, Roger Viadero, Jason R Hunt, Catherine Miller
While most research on West Nile virus (WNV) and its main vector, the Culex mosquito, has been conducted in laboratory or urban settings, studies with field-caught mosquitoes in rural areas, such as west-central Illinois, are lacking. The objective of this research was to investigate key abiotic factors using macroclimate data, including temperature, precipitation, and wind speed, to determine their influence on field-caught mosquito abundance in 4 rural counties in Illinois from 2014 to 2016. Additionally, the relationship between minimum infection rate (MIR) and thermal time was examined...
February 5, 2024: Journal of the American Mosquito Control Association
https://read.qxmd.com/read/38302619/mechanism-matters-mortality-and-endothelial-cell-damage-marker-differences-between-blunt-and-penetrating-traumatic-injuries-across-three-prehospital-clinical-trials
#24
JOURNAL ARTICLE
Jack K Donohue, Danielle S Gruen, Nidhi Iyanna, John M Lorence, Joshua B Brown, Francis X Guyette, Brian J Daley, Brian J Eastridge, Richard S Miller, Raminder Nirula, Brian G Harbrecht, Jeffrey A Claridge, Herb A Phelan, Gary A Vercruysse, Terence O'Keeffe, Bellal Joseph, Matthew D Neal, Timothy R Billiar, Jason L Sperry
Injury mechanism is an important consideration when conducting clinical trials in trauma. Mechanisms of injury may be associated with differences in mortality risk and immune response to injury, impacting the potential success of the trial. We sought to characterize clinical and endothelial cell damage marker differences across blunt and penetrating injured patients enrolled in three large, prehospital randomized trials which focused on hemorrhagic shock. In this secondary analysis, patients with systolic blood pressure < 70 or systolic blood pressure < 90 and heart rate > 108 were included...
February 2, 2024: Scientific Reports
https://read.qxmd.com/read/38300202/hybrid-magnetic-resonance-positron-emission-tomography-is-associated-with-cardiac-related-outcomes-in-cardiac-sarcoidosis
#25
JOURNAL ARTICLE
Maria Giovanna Trivieri, Philip M Robson, Vittoria Vergani, Gina LaRocca, Angelica M Romero-Daza, Ronan Abgral, Ana Devesa, Levi-Dan Azoulay, Nicolas A Karakatsanis, Aditya Parikh, Christia Panagiota, Anna Palmisano, Louis DePalo, Helena L Chang, Joseph H Rothstein, Rima A Fayad, Marc A Miller, Valentin Fuster, Jagat Narula, Marc R Dweck, Adam Morgenthau, Adam Jacobi, Maria Padilla, Jason C Kovacic, Zahi A Fayad
BACKGROUND: Imaging with late gadolinium enhancement (LGE) magnetic resonance (MR) and 18 F-fluorodeoxyglucose (18 F-FDG) PET allows complementary assessment of myocardial injury and disease activity and has shown promise for improved characterization of active cardiac sarcoidosis (CS) based on the combined positive imaging outcome, MR(+)PET(+). OBJECTIVES: This study aims to evaluate qualitative and quantitative assessments of hybrid MR/PET imaging in CS and to evaluate its association with cardiac-related outcomes...
January 20, 2024: JACC. Cardiovascular Imaging
https://read.qxmd.com/read/38282035/molecular-determinants-of-asic1-modulation-by-divalent-cations
#26
JOURNAL ARTICLE
Yi Liu, Jichun Ma, Renee L DesJarlais, Rebecca Hagan, Jason Rech, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael P Maher
Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the nervous system. ASIC gating is modulated by divalent cations as well as small molecules; however, the molecular determinants of gating modulation by divalent cations are not well understood. Previously, we identified two small molecules that bind to ASIC1a at a novel site in the acidic pocket and modulate ASIC1 gating in a manner broadly resembling divalent cations, raising the possibility that these small molecules may help to illuminate the molecular determinants of gating modulation by divalent cations...
January 28, 2024: Scientific Reports
https://read.qxmd.com/read/38278722/clinical-outcomes-of-standardized-central-venous-catheterization-simulation-training-a-comparative-analysis
#27
JOURNAL ARTICLE
Jessica M Gonzalez-Vargas, Elizabeth Sinz, Jason Z Moore, Scarlett R Miller
OBJECTIVE: A standardized ultrasound-guided Internal Jugular Central Venous Catheterization (US-IJCVC) using online- and simulation-based training was first designed and then large-scale deployed at a teaching hospital institution to improve CVC surgical education. To understand the impact that the standardized training might have on patient complications, this study focuses on identifying the impact of the integration of an iteratively designed US-IJCVC training on clinical complications at a teaching hospital...
January 25, 2024: Journal of Surgical Education
https://read.qxmd.com/read/38275218/tempo-and-mode-of-gene-expression-evolution-in-the-brain-across-primates
#28
JOURNAL ARTICLE
Katherine Rickelton, Trisha M Zintel, Jason Pizzollo, Emily Miller, John J Ely, Mary Ann Raghanti, William D Hopkins, Patrick R Hof, Chet C Sherwood, Amy L Bauernfeind, Courtney C Babbitt
Primate evolution has led to a remarkable diversity of behavioral specializations and pronounced brain size variation among species (Barton, 2012; DeCasien & Higham, 2019; Powell, Isler, & Barton, 2017). Gene expression provides a promising opportunity for studying the molecular basis of brain evolution, but it has been explored in very few primate species to date (e.g. Khaitovich et al., 2005; Khrameeva et al., 2020; Ma et al., 2022; Somel et al., 2009). To understand the landscape of gene expression evolution across the primate lineage, we generated and analyzed RNA-Seq data from four brain regions in an unprecedented eighteen species...
January 26, 2024: ELife
https://read.qxmd.com/read/38267212/discovery-of-kin-3248-an-irreversible-next-generation-fgfr-inhibitor-for-the-treatment-of-advanced-tumors-harboring-fgfr2-and-or-fgfr3-gene-alterations
#29
JOURNAL ARTICLE
John S Tyhonas, Lee D Arnold, Jason M Cox, Aleksandra Franovic, Elisabeth Gardiner, Kathryn Grandinetti, Robert Kania, Toufike Kanouni, Matthew Lardy, Chun Li, Eric S Martin, Nichol Miller, Adithi Mohan, Eric A Murphy, Michelle Perez, Liliana Soroceanu, Noel Timple, Sean Uryu, Scott Womble, Stephen W Kaldor
Fibroblast growth factor receptor (FGFR) alterations are present as oncogenic drivers and bypass mechanisms in many forms of cancer. These alterations can include fusions, amplifications, rearrangements, and mutations. Acquired drug resistance to current FGFR inhibitors often results in disease progression and unfavorable outcomes for patients. Genomic profiling of tumors refractory to current FGFR inhibitors in the clinic has revealed several acquired driver alterations that could be the target of next generation therapeutics...
January 24, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38259673/a-longitudinal-metagenomic-comparative-analysis-of-oral-microbiome-shifts-in-patients-receiving-proton-radiation-versus-photon-radiation-for-head-and-neck-cancer
#30
JOURNAL ARTICLE
Timothy F Meiller, Claire M Fraser, Silvia Grant-Beurmann, Mike Humphrys, Luke Tallon, Lisa D Sadzewicz, Mary Ann Jabra-Rizk, Areej Alfaifi, Anmar Kensara, Jason K Molitoris, Matthew Witek, William S Mendes, William F Regine, Phuoc T Tran, Robert C Miller, Ahmed S Sultan
INTRODUCTION: Due to the radiation-sparing effects on salivary gland acini, changes in the composition of the oral microbiome may be a driver for improved outcomes in patients receiving proton radiation, with potentially worse outcomes in patients exposed to photon radiation therapy. To date, a head-to-head comparison of oral microbiome changes at a metagenomic level with longitudinal sampling has yet to be performed in these patient cohorts. METHODS AND MATERIALS: To comparatively analyze oral microbiome shifts during head and neck radiation therapy, a prospective pilot cohort study was performed at the Maryland Proton Treatment Center and the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center...
2024: Journal of cancer & allied specialties
https://read.qxmd.com/read/38235978/rural-ems-stemi-patients-why-the-delay-to-pci
#31
JOURNAL ARTICLE
Jason P Stopyra, Anna C Snavely, Nicklaus P Ashburn, Michael W Supples, W Mark Brown, Chadwick D Miller, Simon A Mahler
BACKGROUND: The objective of this study is to identify patient and EMS agency factors associated with timely reperfusion of patients with ST-elevation myocardial infarction (STEMI). METHODS: We conducted a cohort study of adult patients (≥18 years old) with STEMI activations from 2016-2020. Data was obtained from a regional STEMI registry, which included eight rural county EMS agencies and three North Carolina percutaneous coronary intervention (PCI) centers...
January 18, 2024: Prehospital Emergency Care
https://read.qxmd.com/read/38230963/the-discovery-of-exarafenib-kin-2787-overcoming-the-challenges-of-pan-raf-kinase-inhibition
#32
JOURNAL ARTICLE
Young K Chen, Toufike Kanouni, Lee D Arnold, Jason M Cox, Elisabeth Gardiner, Kathryn Grandinetti, Ping Jiang, Stephen W Kaldor, Catherine Lee, Chun Li, Eric S Martin, Nichol Miller, Eric A Murphy, Noel Timple, John S Tyhonas, Angie Vassar, Tim S Wang, Richard Williams, Ding Yuan, Robert S Kania
RAF, a core signaling component of the MAPK kinase cascade, is often mutated in various cancers, including melanoma, lung, and colorectal cancers. The approved inhibitors were focused on targeting the BRAFV600E mutation that results in constitutive activation of kinase signaling through the monomeric protein (Class I). However, these inhibitors also paradoxically activate kinase signaling of RAF dimers, resulting in increased MAPK signaling in normal tissues. Recently, significant attention has turned to targeting RAF alterations that activate dimeric signaling (class II and III BRAF and NRAS)...
January 17, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38198609/intraocular-pressure-lowering-associated-with-worsening-optic-pit-like-retinoschisis
#33
JOURNAL ARTICLE
Jonah E Yousif, Jason M L Miller
In this article, we present a case of optic pit-like macular retinoschisis in the absence of advanced glaucomatous cupping. Intraocular pressure (IOP)-lowering therapy, which was started due to an early concern for glaucoma, caused a worsening of the retinoschisis, which subsequently resolved on discontinuation of the IOP-lowering therapy. Lower IOP likely triggered intraretinal fluid accumulation by facilitating a translaminar gradient from the subarachnoid to intraretinal space. [ Ophthalmic Surg Lasers Imaging Retina 2024;55:XX-XX...
January 1, 2024: Ophthalmic Surgery, Lasers & Imaging Retina
https://read.qxmd.com/read/38198141/short-stay-units-vs-routine-admission-from-the-emergency-department-in-patients-with-acute-heart-failure-the-ssu-ahf-randomized-clinical-trial
#34
RANDOMIZED CONTROLLED TRIAL
Peter S Pang, David A Berger, Simon A Mahler, Xiaochun Li, Susan J Pressler, Kathleen A Lane, Jason J Bischof, Douglas Char, Deborah Diercks, Alan E Jones, Erik P Hess, Phillip Levy, Joseph B Miller, Arvind Venkat, Nicholas E Harrison, Sean P Collins
IMPORTANCE: More than 80% of patients who present to the emergency department (ED) with acute heart failure (AHF) are hospitalized. With more than 1 million annual hospitalizations for AHF in the US, safe and effective alternatives are needed. Care for AHF in short-stay units (SSUs) may be safe and more efficient than hospitalization, especially for lower-risk patients, but randomized clinical trial data are lacking. OBJECTIVE: To compare the effectiveness of SSU care vs hospitalization in lower-risk patients with AHF...
January 2, 2024: JAMA Network Open
https://read.qxmd.com/read/38190101/multi-ancestry-genetic-analysis-of-gene-regulation-in-coronary-arteries-prioritizes-disease-risk-loci
#35
JOURNAL ARTICLE
Chani J Hodonsky, Adam W Turner, Mohammad Daud Khan, Nelson B Barrientos, Ruben Methorst, Lijiang Ma, Nicolas G Lopez, Jose Verdezoto Mosquera, Gaëlle Auguste, Emily Farber, Wei Feng Ma, Doris Wong, Suna Onengut-Gumuscu, Maryam Kavousi, Patricia A Peyser, Sander W van der Laan, Nicholas J Leeper, Jason C Kovacic, Johan L M Björkegren, Clint L Miller
Genome-wide association studies (GWASs) have identified hundreds of risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in GWASs, and the causal gene-regulatory mechanisms of these risk loci during atherosclerosis remain unclear. We incorporated local ancestry and haplotypes to identify quantitative trait loci for expression (eQTLs) and splicing (sQTLs) in coronary arteries from 138 ancestrally diverse Americans. Of 2,132 eQTL-associated genes (eGenes), 47% were previously unreported in coronary artery; 19% exhibited cell-type-specific expression...
December 7, 2023: Cell Genom
https://read.qxmd.com/read/38176749/rigler-sign-and-hepatic-portal-venous-gas-classic-surgical-radiology
#36
JOURNAL ARTICLE
Justin Essington McKay Hunt, Jason Miller, Jason Brown, Nicholas O'Rourke
No abstract text is available yet for this article.
January 4, 2024: BMJ Case Reports
https://read.qxmd.com/read/38168469/applying-data-science-methodologies-with-artificial-intelligence-variant-reinterpretation-to-map-and-estimate-genetic-disorder-prevalence-utilizing-clinical-data
#37
JOURNAL ARTICLE
Suellen Jackson, Rebecca Freeman, Adriana Noronha, Hafsah Jamil, Eric Chavez, Jason Carmichael, Kaylee M Ruiz, Christine Miller, Sarah Benke, Rosalie Perrot, Maryam Hockley, Kady Murphy, Aimiel Casillan, Lily Radanovich, Roger Deforest, Mark E Nunes, Carolina Galarreta-Aima, Richard Sidlow, Yaron Einhorn, Jeremy Woods
Data science methodologies can be utilized to ascertain and analyze clinical genetic data that is often unstructured and rarely used outside of patient encounters. Genetic variants from all genetic testing resulting to a large pediatric healthcare system for a 5-year period were obtained and reinterpreted utilizing the previously validated Franklin© Artificial Intelligence (AI). Using PowerBI©, the data were further matched to patients in the electronic healthcare record to associate with demographic data to generate a variant data table and mapped by ZIP codes...
January 2, 2024: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/38114498/rbfox2-deregulation-promotes-pancreatic-cancer-progression-and-metastasis-through-alternative-splicing
#38
JOURNAL ARTICLE
Michelle Maurin, Mohammadreza Ranjouri, Cristina Megino-Luque, Justin Y Newberg, Dongliang Du, Katelyn Martin, Robert E Miner, Mollie S Prater, Dave Keng Boon Wee, Barbara Centeno, Shondra M Pruett-Miller, Paul Stewart, Jason B Fleming, Xiaoqing Yu, Jose Javier Bravo-Cordero, Ernesto Guccione, Michael A Black, Karen M Mann
RNA splicing is an important biological process associated with cancer initiation and progression. However, the contribution of alternative splicing to pancreatic cancer (PDAC) development is not well understood. Here, we identify an enrichment of RNA binding proteins (RBPs) involved in splicing regulation linked to PDAC progression from a forward genetic screen using Sleeping Beauty insertional mutagenesis in a mouse model of pancreatic cancer. We demonstrate downregulation of RBFOX2, an RBP of the FOX family, promotes pancreatic cancer progression and liver metastasis...
December 19, 2023: Nature Communications
https://read.qxmd.com/read/38110089/cervical-disc-arthroplasty-versus-anterior-cervical-discectomy-and-fusion-an-analysis-of-the-michigan-spine-surgery-improvement-collaborative-database
#39
JOURNAL ARTICLE
Alex K Miller, Philip Zakko, Daniel K Park, Victor W Chang, Lonni Schultz, Kylie Springer, Travis M Hamilton, Muwaffak M Abdulhak, Jason M Schwalb, David R Nerenz, Ilyas S Aleem, Jad G Khalil
BACKGROUND CONTEXT: Anterior cervical discectomy and fusion (ACDF) and cervical disc arthroplasty (CDA) are established surgical options for the treatment of cervical radiculopathy, myelopathy, and cervical degenerative disc disease. However, current literature does not demonstrate a clear superiority between ACDF and CDA. PURPOSE: To investigate procedural and patient-reported outcomes of ACDF and CDA among patients included in the Michigan Spine Surgery Improvement Collaborative (MSSIC) database...
December 16, 2023: Spine Journal: Official Journal of the North American Spine Society
https://read.qxmd.com/read/38088212/sequence-differences-between-bax-and-bak-core-domains-manifest-as-differences-in-their-interactions-with-lipids
#40
JOURNAL ARTICLE
Michelle S Miller, Angus D Cowan, Jason M Brouwer, Sean T Smyth, Liuyu Peng, Ahmad Z Wardak, Rachel T Uren, Cindy Luo, Michael J Roy, Sayali Shah, Ziwen Tan, Gavin E Reid, Peter M Colman, Peter E Czabotar
The B-cell lymphoma 2 (BCL2) family members, BCL2-associated protein X (BAX) and BCL2 homologous antagonist killer (BAK), are required for programmed cell death via the mitochondrial pathway. When cells are stressed, damaged or redundant, the balance of power between the BCL2 family of proteins shifts towards BAX and BAK, allowing their transition from an inactive, monomeric state to a membrane-active oligomeric form that releases cytochrome c from the mitochondrial intermembrane space. That oligomeric state has an essential intermediate, a symmetric homodimer of BAX or BAK...
December 13, 2023: FEBS Journal
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