Juan M Godoy-Corchuelo, Zeinab Ali, Jose M Brito Armas, Aurea B Martins-Bach, Irene García-Toledo, Luis C Fernández-Beltrán, Juan I López-Carbonero, Pablo Bascuñana, Shoshana Spring, Irene Jimenez-Coca, Ramón A Muñoz de Bustillo Alfaro, Maria J Sánchez-Barrena, Remya R Nair, Brian J Nieman, Jason P Lerch, Karla L Miller, Hande P Ozdinler, Elizabeth M C Fisher, Thomas J Cunningham, Abraham Acevedo-Arozena, Silvia Corrochano
TDP-43 pathology is found in several neurodegenerative disorders, collectively referred to as "TDP-43 proteinopathies". Aggregates of TDP-43 are present in the brains and spinal cords of >97% of amyotrophic lateral sclerosis (ALS), and in brains of ~50% of frontotemporal dementia (FTD) patients. While mutations in the TDP-43 gene (TARDBP) are usually associated with ALS, many clinical reports have linked these mutations to cognitive impairments and/or FTD, but also to other neurodegenerative disorders including Parkinsonism (PD) or progressive supranuclear palsy (PSP)...
February 15, 2024: Neurobiology of Disease