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https://www.readbyqxmd.com/read/28334843/a152t-tau-allele-causes-neurodegeneration-that-can-be-ameliorated-in-a-zebrafish-model-by-autophagy-induction
#1
Ana Lopez, Suzee E Lee, Kevin Wojta, Eliana Marisa Ramos, Eric Klein, Jason Chen, Adam L Boxer, Maria Luisa Gorno-Tempini, Daniel H Geschwind, Lars Schlotawa, Nikolay V Ogryzko, Eileen H Bigio, Emily Rogalski, Sandra Weintraub, Marsel M Mesulam, Angeleen Fleming, Giovanni Coppola, Bruce L Miller, David C Rubinsztein
Mutations in the gene encoding tau (MAPT) cause frontotemporal dementia spectrum disorders. A rare tau variant p.A152T was reported as a risk factor for frontotemporal dementia spectrum and Alzheimer's disease in an initial case-control study. Such findings need replication in an independent cohort. We analysed an independent multinational cohort comprising 3100 patients with neurodegenerative disease and 4351 healthy control subjects and found p.A152T associated with significantly higher risk for clinically defined frontotemporal dementia and progressive supranuclear palsy syndrome...
February 9, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28333508/morphological-variability-in-second-language-learners-an-examination-of-electrophysiological-and-production-data
#2
José Alemán Bañón, David Miller, Jason Rothman
We examined sources of morphological variability in second language (L2) learners of Spanish whose native language (L1) is English, with a focus on L1-L2 similarity, morphological markedness, and knowledge type (receptive vs. expressive). Experiment 1 uses event-related potentials to examine noun-adjective number (present in L1) and gender agreement (absent in L1) in online sentence comprehension (receptive knowledge). For each feature, markedness was manipulated, such that half of the critical noun-adjective combinations were feminine (marked) and the other half were masculine; half were used in the plural (marked) and the other half were used in the singular...
March 23, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28328947/a-spontaneous-mutation-in-kdsd-a-biosynthesis-gene-for-3-deoxy-d-manno-octulosonic-acid-occurred-in-a-ciprofloxacin-resistant-strain-of-francisella-tularensis-and-caused-a-high-level-of-attenuation-in-murine-models-of-tularemia
#3
Taylor Chance, Jennifer Chua, Ronald G Toothman, Jason T Ladner, Jonathan E Nuss, Jo Lynne Raymond, Fabrice V Biot, Samandra Demons, Lynda Miller, Stephanie Halasohoris, Sherry Mou, Galina Koroleva, Sean Lovett, Gustavo Palacios, Nicholas J Vietri, Patricia L Worsham, Christopher K Cote, Todd M Kijek, Joel A Bozue
Francisella tularensis, a gram-negative facultative intracellular bacterial pathogen, is the causative agent of tularemia and able to infect many mammalian species, including humans. Because of its ability to cause a lethal infection, low infectious dose, and aerosolizable nature, F. tularensis subspecies tularensis is considered a potential biowarfare agent. Due to its in vitro efficacy, ciprofloxacin is one of the antibiotics recommended for post-exposure prophylaxis of tularemia. In order to identify therapeutics that will be efficacious against infections caused by drug resistant select-agents and to better understand the threat, we sought to characterize an existing ciprofloxacin resistant (CipR) mutant in the Schu S4 strain of F...
2017: PloS One
https://www.readbyqxmd.com/read/28328629/clinical-biomechanical-and-anatomic-investigation-of-colles-fascia-and-pubic-ramus-periosteum-for-use-during-medial-thighplasty
#4
Martin J Carney, Tim Matatov, Matthew Freeman, John Miller, Rahul Vemula, Jason Schuster, Michael Dancisak, John Lindsey, Guenevere Rae
INTRODUCTION: The medial thighplasty is a procedure where patients may attain superior mobility, hygiene, and cosmesis. Most surgeons use attachment of the superficial fascial system (SFS) of the thigh flap to the Colles fascia, whereas others attach the SFS to the pubic ramus periosteum. Because of a high complication profile, we aim to elucidate the clinical, biomechanical, and anatomic qualities of the Colles fascia versus the pubic ramus periosteum. MATERIALS AND METHODS: We performed a 17-year retrospective review documenting clinical complications, a biomechanical analysis of sutures placed in different tissue layers of the thigh, and a histologic analysis surrounding the ischiopubic ramus...
March 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28300075/a-human-antibody-against-zika-virus-crosslinks-the-e-protein-to-prevent-infection
#5
S Saif Hasan, Andrew Miller, Gopal Sapparapu, Estefania Fernandez, Thomas Klose, Feng Long, Andrei Fokine, Jason C Porta, Wen Jiang, Michael S Diamond, James E Crowe, Richard J Kuhn, Michael G Rossmann
The recent Zika virus (ZIKV) epidemic has been linked to unusual and severe clinical manifestations including microcephaly in fetuses of infected pregnant women and Guillian-Barré syndrome in adults. Neutralizing antibodies present a possible therapeutic approach to prevent and control ZIKV infection. Here we present a 6.2 Å resolution three-dimensional cryo-electron microscopy (cryoEM) structure of an infectious ZIKV (strain H/PF/2013, French Polynesia) in complex with the Fab fragment of a highly therapeutic and neutralizing human monoclonal antibody, ZIKV-117...
March 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28298431/canu-scalable-and-accurate-long-read-assembly-via-adaptive-k-mer-weighting-and-repeat-separation
#6
Sergey Koren, Brian P Walenz, Konstantin Berlin, Jason R Miller, Nicholas H Bergman, Adam M Phillippy
Long-read single-molecule sequencing has revolutionized de novo genome assembly and enabled the automated reconstruction of reference-quality genomes. However, given the relatively high error rates of such technologies, efficient and accurate assembly of large repeats and closely related haplotypes remains challenging. We address these issues with Canu, a successor of Celera Assembler that is specifically designed for noisy single-molecule sequences. Canu introduces support for nanopore sequencing, halves depth-of-coverage requirements, and improves assembly continuity while simultaneously reducing runtime by an order of magnitude on large genomes versus Celera Assembler 8...
March 15, 2017: Genome Research
https://www.readbyqxmd.com/read/28297351/output-factor-comparison-of-monte-carlo-and-measurement-for-varian-truebeam-6-mv-and-10-mv-flattening-filter-free-stereotactic-radiosurgery-system
#7
Jason Y Cheng, Holly Ning, Barbara C Arora, Ying Zhuge, Robert W Miller
The dose measurements of the small field sizes, such as conical collimators used in stereotactic radiosurgery (SRS), are a significant challenge due to many factors including source occlusion, detector size limitation, and lack of lateral electronic equilibrium. One useful tool in dealing with the small field effect is Monte Carlo (MC) simulation. In this study, we report a comparison of Monte Carlo simulations and measurements of output factors for the Varian SRS system with conical collimators for energies of 6 MV flattening filter-free (6 MV) and 10 MV flattening filter-free (10 MV) on the TrueBeam accelerator...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28294975/reverse-transcription-in-the-saccharomyces-cerevisiae-long-terminal-repeat-retrotransposon-ty3
#8
REVIEW
Jason W Rausch, Jennifer T Miller, Stuart F J Le Grice
Converting the single-stranded retroviral RNA into integration-competent double-stranded DNA is achieved through a multi-step process mediated by the virus-coded reverse transcriptase (RT). With the exception that it is restricted to an intracellular life cycle, replication of the Saccharomyces cerevisiae long terminal repeat (LTR)-retrotransposon Ty3 genome is guided by equivalent events that, while generally similar, show many unique and subtle differences relative to the retroviral counterparts. Until only recently, our knowledge of RT structure and function was guided by a vast body of literature on the human immunodeficiency virus (HIV) enzyme...
March 15, 2017: Viruses
https://www.readbyqxmd.com/read/28291944/pyrolyzable-nanoparticle-tracers-for-environmental-interrogation-and-monitoring
#9
Jason R Cox, Mohammed Alsenani, Scott E Miller, James A Roush, Rena Shi, Hooisweng Ow, Sehoon Chang, Anthony A Kmetz, Shannon L Eichmann, Martin E Poitzsch
Environmental tracing applications require materials that can be detected in complex fluids composed of multiple phases and contaminants. Moreover, large libraries of tracers are necessary in order to mitigate memory effects and to deploy multiple tracers simultaneously in complex oil fields. Herein, we disclose a novel approach based on the thermal decomposition of polymeric nanoparticles comprised of styrenic and methacrylic monomers. Polymeric nanoparticles derived from these monomers cleanly decompose into their constituent monomers at elevated temperatures, thereby maximizing atom economy wherein the entire nanoparticle mass contributes to the generation of detectable units...
March 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28279545/social-media-use-and-perceived-social-isolation-among-young-adults-in-the-u-s
#10
Brian A Primack, Ariel Shensa, Jaime E Sidani, Erin O Whaite, Liu Yi Lin, Daniel Rosen, Jason B Colditz, Ana Radovic, Elizabeth Miller
INTRODUCTION: Perceived social isolation (PSI) is associated with substantial morbidity and mortality. Social media platforms, commonly used by young adults, may offer an opportunity to ameliorate social isolation. This study assessed associations between social media use (SMU) and PSI among U.S. young adults. METHODS: Participants were a nationally representative sample of 1,787 U.S. adults aged 19-32 years. They were recruited in October-November 2014 for a cross-sectional survey using a sampling frame that represented 97% of the U...
February 24, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28279291/clinical-benefit-of-ablating-localized-sources-for-human-atrial-fibrillation-the-indiana-university-firm-registry
#11
John M Miller, Vikas Kalra, Mithilesh K Das, Rahul Jain, Jason B Garlie, Jordan A Brewster, Gopi Dandamudi
BACKGROUND: Mounting evidence shows that localized sources maintain atrial fibrillation (AF). However, it is unclear in unselected "real-world" patients if sources drive persistent atrial fibrillation (PeAF), long-standing persistent atrial fibrillation (LPeAF), or paroxysmal atrial fibrillation (PAF); if right atrial sites are important; and what the long-term success of source ablation is. OBJECTIVES: The aim of this study was to analyze the role of rotors and focal sources in a large academic registry of consecutive patients undergoing source mapping for AF...
March 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28267733/us-immigration-order-strikes-against-biotech
#12
Jeremy M Levin, Steven H Holtzman, John Maraganore, Paul J Hastings, Ron Cohen, Bassil Dahiyat, Julian Adams, Chris Adams, Brett Ahrens, Jeff Albers, Mara G Aspinall, James E Audia, Martin Babler, Peter Barrett, Zoe Barry, Nessan Bermingham, Stephen Bloch, Robert I Blum, Paul B Bolno, Michael W Bonney, Bruce Booth, Daniel M Bradbury, Steven K Brauer, Brook Byers, Pablo J Cagnoni, Brian M Cali, Isaac Ciechanover, Chip Clark, Michael D Clayman, Jeff L Cleland, Paula Cobb, Ron Cooper, Mark G Currie, John Diekman, Eric L Dobmeier, Doug Doerfler, Elizabeth Lr Donley, Deborah Dunsire, Matthew During, Jens W Eckstein, Eric Elenko, Neil A Exter, Jonathan J Fleming, Gregory J Flesher, Jean-Francois Formela, Robert Forrester, Cedric Francois, Heather Franklin, Mason W Freeman, Howard Furst, Leonard Patrick Gage, Nicholas Galakatos, Brian M Gallagher, James A Geraghty, Simba Gill, David V Goeddel, Mark A Goldsmith, Maxine Gowen, Vikas Goyal, Tom Graney, David Grayzel, Barry Greene, Paul Grint, J C Gutierrez-Ramos, Bill Haney, Tuan Ha-Ngoc, Tim Harris, Faheem Hasnain, Yujiro Steve Hata, Peter Hecht, Leslie Henshaw, Rich Heyman, Herve Hoppenot, H Robert Horvitz, Thomas E Hughes, Wende S Hutton, Stephen T Isaacs, Annalisa Jenkins, Jeff Jonker, Jeff Kaplan, Perry Karsen, Jeb Keiper, Jean Kim, Jeff Kindler, Rachel King, Vanessa King, Nina Kjellson, Scott Koenig, Gerhard Koenig, Peter Kolchinsky, Paul Laikind, Robert Bob Langer, John J Lee, Jonathan S Leff, Bruce A Leicher, Nick Leschly, Andrew Levin, Mark Levin, Arnold J Levine, Alan Levy, David R Liu, Harvey F Lodish, Uri Lopatin, Ted W Love, Guy Macdonald, Gail J Maderis, Ankit Mahadevia, Nagesh K Mahanthappa, Joel F Martin, Alex Martin, W Eddie Martucci, James G McArthur, Corey M McCann, Sean A McCarthy, C Geoffrey McDonough, John Mendlein, Larry Miller, Diego Miralles, Kenneth I Moch, Bob More, Andrew G Myers, Michael A Narachi, Amir Nashat, Wendy Nelson, William J Newell, Bernat Olle, John E Osborn, Julia C Owens, Atul Pande, Stelios Papadopoulos, H Stewart Parker, Kush M Parmar, Matthew R Patterson, Steve M Paul, Rob Perez, Matthew Perry, Cary G Pfeffer, Mike Powell, Mark Pruzanski, Dennis J Purcell, Amit Rakhit, Kartik Ramamoorthi, William Rastetter, Adrian Ad Rawcliffe, Laurence E Reid, Ron C Renaud, Jason P Rhodes, William J Rieflin, Chad Robins, Scott M Rocklage, Michael Rosenblatt, Jonathan G Rosin, William J Rutter, Saurabh Saha, Camille Samuels, Vicki L Sato, George Scangos, John A Scarlett, David Schenkein, Stuart L Schreiber, Andrew Schwab, Paul Sekhri, Rajeev Shah, Thomas Shenk, Clay B Siegall, Nick J Simon, Nancy Simonian, Jeff Stein, Michael Su, Mary T Szela, Marco Taglietti, Nina Tandon, Henri Termeer, Nancy A Thornberry, Martin Tolar, Richard Ulevitch, Akshay K Vaishnaw, Anne VanLent, Martin Varsavsky, George P Vlasuk, Michel Vounatsos, Samuel G Waksal, Neil Warma, Ryan J Watts, Yaron Werber, Christoph Westphal, Wendell Wierenga, Doug E Williams, Lewis Rusty Williams, Kleanthis G Xanthopoulos, Daphne Zohar, Sandford Sandy Zweifach
No abstract text is available yet for this article.
March 7, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28266154/enhanced-atrazine-degradation-is-widespread-across-the-united-states
#13
Thomas C Mueller, Ethan T Parker, Larry Steckel, Sharon A Clay, Micheal D K Owen, William S Curran, Randall Currie, Robert Scott, Christy Sprague, Daniel O Stephenson, Donnie K Miller, Eric P Prostko, W James Grichar, James Martin, L Jason Kruz, Kevin Bradley, Mark L Bernards, Peter Dotray, Stevan Knezevic, Vince Davis, Robert Klein
BACKGROUND: Atrazine (ATZ) has been a key herbicide for annual weed control in corn, with both a soil and postemergence vegetation application period. Although enhanced ATZ degradation in soil with a history of ATZ use has been reported, the extent and rate of degradation in the U.S. Corn Belt is uncertain. We show that enhanced ATZ degradation exists across much of the country. RESULTS: Soils from 15 of 16 surveyed states had enhanced ATZ degradation. The average ATZ half-life was only 2...
March 7, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28265087/classroom-sound-can-be-used-to-classify-teaching-practices-in-college-science-courses
#14
Melinda T Owens, Shannon B Seidel, Mike Wong, Travis E Bejines, Susanne Lietz, Joseph R Perez, Shangheng Sit, Zahur-Saleh Subedar, Gigi N Acker, Susan F Akana, Brad Balukjian, Hilary P Benton, J R Blair, Segal M Boaz, Katharyn E Boyer, Jason B Bram, Laura W Burrus, Dana T Byrd, Natalia Caporale, Edward J Carpenter, Yee-Hung Mark Chan, Lily Chen, Amy Chovnick, Diana S Chu, Bryan K Clarkson, Sara E Cooper, Catherine Creech, Karen D Crow, José R de la Torre, Wilfred F Denetclaw, Kathleen E Duncan, Amy S Edwards, Karen L Erickson, Megumi Fuse, Joseph J Gorga, Brinda Govindan, L Jeanette Green, Paul Z Hankamp, Holly E Harris, Zheng-Hui He, Stephen Ingalls, Peter D Ingmire, J Rebecca Jacobs, Mark Kamakea, Rhea R Kimpo, Jonathan D Knight, Sara K Krause, Lori E Krueger, Terrye L Light, Lance Lund, Leticia M Márquez-Magaña, Briana K McCarthy, Linda J McPheron, Vanessa C Miller-Sims, Christopher A Moffatt, Pamela C Muick, Paul H Nagami, Gloria L Nusse, Kristine M Okimura, Sally G Pasion, Robert Patterson, Pleuni S Pennings, Blake Riggs, Joseph Romeo, Scott W Roy, Tatiane Russo-Tait, Lisa M Schultheis, Lakshmikanta Sengupta, Rachel Small, Greg S Spicer, Jonathon H Stillman, Andrea Swei, Jennifer M Wade, Steven B Waters, Steven L Weinstein, Julia K Willsie, Diana W Wright, Colin D Harrison, Loretta A Kelley, Gloriana Trujillo, Carmen R Domingo, Jeffrey N Schinske, Kimberly D Tanner
Active-learning pedagogies have been repeatedly demonstrated to produce superior learning gains with large effect sizes compared with lecture-based pedagogies. Shifting large numbers of college science, technology, engineering, and mathematics (STEM) faculty to include any active learning in their teaching may retain and more effectively educate far more students than having a few faculty completely transform their teaching, but the extent to which STEM faculty are changing their teaching methods is unclear...
March 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28263858/predicting-mortality-and-independence-at-discharge-in-the-aging-traumatic-brain-injury-population-using-data-available-at-admission
#15
Preston R Miller, Michael C Chang, J Jason Hoth, Amy N Hildreth, Stacey Q Wolfe, Jessica L Gross, R Shayn Martin, Jeffrey E Carter, J Wayne Meredith, Ralph D'Agostino
INTRODUCTION: Aging worsens outcome in traumatic brain injury (TBI), but available studies may not provide accurate outcome predictions due to confounding associated injuries. Our goal was to develop a predictive tool using variables available at admission to predict outcome related to severity of brain injury in aging patients. METHODS: Characteristics and outcomes of blunt trauma patients with isolated TBI of ages ≥ 50 in National Trauma Data Bank (NTDB) were evaluated...
January 31, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28257570/pattern-breaks-on-the-surface-ecg-can-we-anticipate-a-long-day-ahead
#16
EDITORIAL
Jason S Bradfield, Kalyanam Shivkumar
In 1988, Miller and colleagues(1) reported their experience with the correlation between 12-lead electrocardiograms (ECG) and endocardial sites of ventricular tachycardia (VT) origin in patients with coronary artery disease. In this series of 182 VTs in 108 patients, they noted numerous precordial transition patterns, one of which was a "regression/growth" pattern, with loss of R waves in the mid- precordial leads and then "regrowth" in the left precordial leads during right bundle branch block morphology VT...
March 3, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28253932/does-the-low-prevalence-affect-the-sample-size-of-interventional-clinical-trials-of-rare-diseases-an-analysis-of-data-from-the-aggregate-analysis-of-clinicaltrials-gov
#17
Siew Wan Hee, Adrian Willis, Catrin Tudur Smith, Simon Day, Frank Miller, Jason Madan, Martin Posch, Sarah Zohar, Nigel Stallard
BACKGROUND: Clinical trials are typically designed using the classical frequentist framework to constrain type I and II error rates. Sample sizes required in such designs typically range from hundreds to thousands of patients which can be challenging for rare diseases. It has been shown that rare disease trials have smaller sample sizes than non-rare disease trials. Indeed some orphan drugs were approved by the European Medicines Agency based on studies with as few as 12 patients. However, some studies supporting marketing authorisation included several hundred patients...
March 2, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28251903/integrated-molecular-analysis-of-tumor-biopsies-on-sequential-ctla-4-and-pd-1-blockade-reveals-markers-of-response-and-resistance
#18
Whijae Roh, Pei-Ling Chen, Alexandre Reuben, Christine N Spencer, Peter A Prieto, John P Miller, Vancheswaran Gopalakrishnan, Feng Wang, Zachary A Cooper, Sangeetha M Reddy, Curtis Gumbs, Latasha Little, Qing Chang, Wei-Shen Chen, Khalida Wani, Mariana Petaccia De Macedo, Eveline Chen, Jacob L Austin-Breneman, Hong Jiang, Jason Roszik, Michael T Tetzlaff, Michael A Davies, Jeffrey E Gershenwald, Hussein Tawbi, Alexander J Lazar, Patrick Hwu, Wen-Jen Hwu, Adi Diab, Isabella C Glitza, Sapna P Patel, Scott E Woodman, Rodabe N Amaria, Victor G Prieto, Jianhua Hu, Padmanee Sharma, James P Allison, Lynda Chin, Jianhua Zhang, Jennifer A Wargo, P Andrew Futreal
Immune checkpoint blockade produces clinical benefit in many patients. However, better biomarkers of response are still needed, and mechanisms of resistance remain incompletely understood. To address this, we recently studied a cohort of melanoma patients treated with sequential checkpoint blockade against cytotoxic T lymphocyte antigen-4 (CTLA-4) followed by programmed death receptor-1 (PD-1) and identified immune markers of response and resistance. Building on these studies, we performed deep molecular profiling including T cell receptor sequencing and whole-exome sequencing within the same cohort and demonstrated that a more clonal T cell repertoire was predictive of response to PD-1 but not CTLA-4 blockade...
March 1, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28250468/drop-on-demand-sample-delivery-for-studying-biocatalysts-in-action-at-x-ray-free-electron-lasers
#19
Franklin D Fuller, Sheraz Gul, Ruchira Chatterjee, E Sethe Burgie, Iris D Young, Hugo Lebrette, Vivek Srinivas, Aaron S Brewster, Tara Michels-Clark, Jonathan A Clinger, Babak Andi, Mohamed Ibrahim, Ernest Pastor, Casper de Lichtenberg, Rana Hussein, Christopher J Pollock, Miao Zhang, Claudiu A Stan, Thomas Kroll, Thomas Fransson, Clemens Weninger, Markus Kubin, Pierre Aller, Louise Lassalle, Philipp Bräuer, Mitchell D Miller, Muhamed Amin, Sergey Koroidov, Christian G Roessler, Marc Allaire, Raymond G Sierra, Peter T Docker, James M Glownia, Silke Nelson, Jason E Koglin, Diling Zhu, Matthieu Chollet, Sanghoon Song, Henrik Lemke, Mengning Liang, Dimosthenis Sokaras, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Amie K Boal, J Martin Bollinger, Carsten Krebs, Martin Högbom, George N Phillips, Richard D Vierstra, Nicholas K Sauter, Allen M Orville, Jan Kern, Vittal K Yachandra, Junko Yano
X-ray crystallography at X-ray free-electron laser sources is a powerful method for studying macromolecules at biologically relevant temperatures. Moreover, when combined with complementary techniques like X-ray emission spectroscopy, both global structures and chemical properties of metalloenzymes can be obtained concurrently, providing insights into the interplay between the protein structure and dynamics and the chemistry at an active site. The implementation of such a multimodal approach can be compromised by conflicting requirements to optimize each individual method...
February 27, 2017: Nature Methods
https://www.readbyqxmd.com/read/28250416/top2-synergizes-with-baf-chromatin-remodeling-for-both-resolution-and-formation-of-facultative-heterochromatin
#20
Erik L Miller, Diana C Hargreaves, Cigall Kadoch, Chiung-Ying Chang, Joseph P Calarco, Courtney Hodges, Jason D Buenrostro, Kairong Cui, William J Greenleaf, Keji Zhao, Gerald R Crabtree
The resolution and formation of facultative heterochromatin are essential for development, reprogramming, and oncogenesis. The mechanisms underlying these changes are poorly understood owing to the difficulty of studying heterochromatin dynamics and structure in vivo. We devised an in vivo approach to investigate these mechanisms and found that topoisomerase II (TOP2), but not TOP1, synergizes with BAF (mSWI/SNF) ATP-dependent chromatin remodeling complexes genome-wide to resolve facultative heterochromatin to accessible chromatin independent of transcription...
February 27, 2017: Nature Structural & Molecular Biology
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