keyword
https://read.qxmd.com/read/38489816/clinical-evaluation-of-a-stereotactic-system-for-single-stage-deep-brain-stimulation-surgery-under-general-anesthesia-technical-note
#1
JOURNAL ARTICLE
Kristen M Scheitler, Aaron E Rusheen, Jason Yuen, Abhinav Goyal, Sukwoo Hong, Gamaleldin M Osman, Basel Sharaf, Bryan T Klassen, Sanjeet S Grewal, Kai J Miller, Hojin Shin, Yoonbae Oh, Kendall H Lee
OBJECTIVE: Conventional frame-based stereotactic systems have circumferential base frames, often necessitating deep brain stimulation (DBS) surgery in two stages: intracranial electrode insertion followed by surgical re-preparation and pulse generator implantation. Some patients do not tolerate awake surgery, underscoring the need for a safe alternative for asleep DBS surgery. A frame-based stereotactic system with a skull-mounted "key" in lieu of a circumferential base frame received US FDA clearance...
March 15, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38482574/jugular-venous-flow-dynamics-during-acute-weightlessness
#2
JOURNAL ARTICLE
Karina Marshall-Goebel, Stuart M C Lee, Jason R Lytle, David S Martin, Christopher A Miller, Millennia Young, Steven S Laurie, Brandon R Macias
During spaceflight fluids shift headward, causing internal jugular vein (IJV) distension and altered hemodynamics, including stasis and retrograde flow, that may increase the risk of thrombosis. This study's purpose was to determine the effects of acute exposure to weightlessness (0-G) on IJV dimensions and flow dynamics. We used 2D ultrasound to measure IJV cross-sectional area (CSA) and Doppler ultrasound to characterize venous blood flow patterns in the right and left IJV in 13 healthy participants (6 female) while 1) seated and supine on the ground, 2) supine during 0-G parabolic flight, and 3) supine during level flight (at 1-G)...
March 14, 2024: Journal of Applied Physiology
https://read.qxmd.com/read/38475727/machine-learning-on-alignment-features-for-parent-of-origin-classification-of-simulated-hybrid-rna-seq
#3
JOURNAL ARTICLE
Jason R Miller, Donald A Adjeroh
BACKGROUND: Parent-of-origin allele-specific gene expression (ASE) can be detected in interspecies hybrids by virtue of RNA sequence variants between the parental haplotypes. ASE is detectable by differential expression analysis (DEA) applied to the counts of RNA-seq read pairs aligned to parental references, but aligners do not always choose the correct parental reference. RESULTS: We used public data for species that are known to hybridize. We measured our ability to assign RNA-seq read pairs to their proper transcriptome or genome references...
March 12, 2024: BMC Bioinformatics
https://read.qxmd.com/read/38456417/need-for-a-cardiogenic-shock-team-collaborative-promoting-a-team-based-model-of-care-to-improve-outcomes-and-identify-best-practices
#4
REVIEW
Balimkiz Senman, Jacob C Jentzer, Christopher F Barnett, Jason A Bartos, David D Berg, Sharon Chih, Stavros G Drakos, David M Dudzinski, Andrea Elliott, Ann Gage, James M Horowitz, P Elliott Miller, Shashank S Sinha, Behnam N Tehrani, Eugene Yuriditsky, Saraschandra Vallabhajosyula, Jason N Katz
Cardiogenic shock continues to carry a high mortality rate despite contemporary care, with no breakthrough therapies shown to improve survival over the past few decades. It is a time-sensitive condition that commonly results in cardiovascular complications and multisystem organ failure, necessitating multidisciplinary expertise. Managing patients with cardiogenic shock remains challenging even in well-resourced settings, and an important subgroup of patients may require cardiac replacement therapy. As a result, the idea of leveraging the collective cognitive and procedural proficiencies of multiple providers in a collaborative, team-based approach to care (the "shock team") has been advocated by professional societies and implemented at select high-volume clinical centers...
March 8, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38451810/the-impact-of-hamstring-lengthening-on-stance-knee-flexion-at-skeletal-maturity-in-ambulatory-cerebral-palsy
#5
JOURNAL ARTICLE
Bidzina Kanashvili, Timothy A Niiler, Chris Church, Nancy Lennon, M Wade Shrader, Jason J Howard, Freeman Miller
This study reports the long-term outcomes of hamstring lengthening to treat flexed knee gait in children with ambulatory cerebral palsy (CP) after skeletal maturity. This retrospective longitudinal observational study used instrumented gait analysis (GA) <8 and >15 years old in children with bilateral CP. The primary variable was knee flexion in stance phase. Eighty children (160 limbs) were included; 49% were male, 51% female. Mean age at first GA was 6.0 (SD: 1.2) years and 19.6 (SD: 4.5) years at final GA...
February 26, 2024: Journal of Pediatric Orthopedics. Part B
https://read.qxmd.com/read/38450121/progressive-medical-simulation-an-analysis-of-the-integration-of-progressive-and-personalized-learning-in-central-line-simulators
#6
JOURNAL ARTICLE
Isra K Elsaadany, Jessica M Gonzalez-Vargas, Jason Z Moore, Scarlett R Miller
Progressive learning gradually increases task difficulty as students advance in their education. One area that can benefit from it is medical education since it can optimize medical trainees' skill acquisition. While progressive learning can allow for skill transfer to patient encounters, personalized learning increases the efficiency and effectiveness of learning. However, it is not well understood the number of practice trials needed to reach proficiency. To evaluate whether progressive and personalized learning can enhance medical trainees' learning gains, the learning interface of the Dynamic Haptic Robotic Trainer (DHRT) for Central Venous Catheterization was assessed...
September 2023: Proceedings of the Human Factors and Ergonomics Society ... Annual Meeting
https://read.qxmd.com/read/38450120/shifting-perspectives-a-proposed-framework-for-analyzing-head-mounted-eye-tracking-data-with-dynamic-areas-of-interest-and-dynamic-scenes
#7
JOURNAL ARTICLE
Haroula M Tzamaras, Hang-Ling Wu, Jason Z Moore, Scarlett R Miller
Eye-tracking is a valuable research method for understanding human cognition and is readily employed in human factors research, including human factors in healthcare. While wearable mobile eye trackers have become more readily available, there are no existing analysis methods for accurately and efficiently mapping dynamic gaze data on dynamic areas of interest (AOIs), which limits their utility in human factors research. The purpose of this paper was to outline a proposed framework for automating the analysis of dynamic areas of interest by integrating computer vision and machine learning (CVML)...
September 2023: Proceedings of the Human Factors and Ergonomics Society ... Annual Meeting
https://read.qxmd.com/read/38441159/six-square-miles-of-urban-america-association-between-firearm-discharge-injury-and-fatality
#8
JOURNAL ARTICLE
William B Risinger, Chinweotuto V Uma, Matthew V Benns, Matthew H Ruther, Nicholas A Nash, Matthew C Bozeman, Jamie C Coleman, Jason W Smith, Brian G Harbrecht, Keith R Miller
BACKGROUND: Despite the increase in firearm injury observed across the country, significant gaps remain relevant to our understanding of how firearm exposure translates to injury. Using acoustic gunshot detection and a collaborative hospital and law enforcement firearm injury database, we sought to identify the relationship between firearm discharge and injury over time. STUDY DESIGN: From 2018-2021, instances of firearm discharge captured via acoustic detection in six-square miles of Louisville, KY was merged with data from the collaborative firearm injury database...
March 5, 2024: Journal of the American College of Surgeons
https://read.qxmd.com/read/38440984/design-of-abrasion-resistant-long-lasting-antifog-coatings
#9
JOURNAL ARTICLE
Brian Macdonald, Fan-Wei Wang, Brian Tobelmann, Jing Wang, Jason Landini, Nipuli Gunaratne, Joseph Kovac, Todd Miller, Ravi Mosurkal, Anish Tuteja
Fog formation is a common challenge for numerous applications, such as food packaging, mirrors, building windows, and freezer/refrigerator doors. Most notably, fog forms on the inner surfaces of prescription glasses and safety eyewear (particularly when used with a mask), face shields, and helmet lenses. Fogging is caused by the distortion of light from condensed water droplets present on a surface and can typically be prevented if the surface static water contact angle (θ) is less than ∼40°...
March 5, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38430544/an-online-behavioural-self-help-intervention-rapidly-improves-acute-insomnia-severity-and-subjective-mood-during-the-covid-19-pandemic-a-stratified-randomised-controlled-trial
#10
JOURNAL ARTICLE
Greg J Elder, Nayantara Santhi, Amelia R Robson, Pamela Alfonso-Miller, Kai Spiegelhalder, Jason G Ellis
STUDY OBJECTIVES: Stressful life events, such as the COVID-19 pandemic, can cause acute insomnia. Cognitive behavioural therapy for acute insomnia is effective but is both time and resource-intensive. This study investigated if an online behavioural self-help intervention, which has been successfully used alongside sleep restriction for acute insomnia, reduced insomnia severity and improved mood in acute insomnia. This study also assessed good sleepers to explore if a "sleep vaccination" approach was feasible...
March 2, 2024: Sleep
https://read.qxmd.com/read/38430499/psychological-flexibility-predicts-perceived-stress-in-doctor-of-physical-therapy-students
#11
JOURNAL ARTICLE
Jason Cherry, Marilyn E Miller
PURPOSE: University students generally, and Doctor of Physical Therapy (DPT) students specifically, experience stress that may threaten their well-being and academic performance with implications after graduation. Universities can benefit from implementing strategies to help students develop stress management skills. An essential first step is identifying modifiable psychological variables that allow students to cope positively with stress. Psychological flexibility may represent one such variable...
2024: Journal of Allied Health
https://read.qxmd.com/read/38416845/a-functional-identification-platform-reveals-frequent-spontaneous-neoantigen-specific-t-cell-responses-in-patients-with-cancer
#12
JOURNAL ARTICLE
Aaron M Miller, Zeynep Koşaloğlu-Yalçın, Luise Westernberg, Leslie Montero, Milad Bahmanof, Angela Frentzen, Manasa Lanka, Ashmitaa Logandha Ramamoorthy Premlal, Gregory Seumois, Jason Greenbaum, Spencer E Brightman, Karla Soria Zavala, Rukman R Thota, Martin S Naradikian, Samir S Makani, Scott M Lippman, Alessandro Sette, Ezra E W Cohen, Bjoern Peters, Stephen P Schoenberger
The clinical impact of tumor-specific neoantigens as both immunotherapeutic targets and biomarkers has been impeded by the lack of efficient methods for their identification and validation from routine samples. We have developed a platform that combines bioinformatic analysis of tumor exomes and transcriptional data with functional testing of autologous peripheral blood mononuclear cells (PBMCs) to simultaneously identify and validate neoantigens recognized by naturally primed CD4+ and CD8+ T cell responses across a range of tumor types and mutational burdens...
February 28, 2024: Science Translational Medicine
https://read.qxmd.com/read/38387826/drug-approval-for-the-treatment-of-geographic-atrophy-how-we-got-here-and-where-we-need-to-go
#13
JOURNAL ARTICLE
Karl G Csaky, Jason Ml Miller, Daniel F Martin, Mark W Johnson
PURPOSE: To discuss the clinical trial results leading to the FDA approval of anti-complement therapies for geographic atrophy (GA), perspectives on functional data from the GA clinical trials, and how lessons from the FDA approval may guide future directions for basic and clinical research in AMD. DESIGN: Selected literature review with analysis and perspective METHODS: We performed a targeted review of publicly available data from the clinical trials of pegcetacoplan and avacincaptad for the treatment of GA as well as scientific literature on the natural history of GA and the genetics and basic science of complement in AMD...
February 20, 2024: American Journal of Ophthalmology
https://read.qxmd.com/read/38378768/prefusion-stabilized-sars-cov-2-s2-only-antigen-provides-protection-against-sars-cov-2-challenge
#14
JOURNAL ARTICLE
Ching-Lin Hsieh, Sarah R Leist, Emily Happy Miller, Ling Zhou, John M Powers, Alexandra L Tse, Albert Wang, Ande West, Mark R Zweigart, Jonathan C Schisler, Rohit K Jangra, Kartik Chandran, Ralph S Baric, Jason S McLellan
Ever-evolving SARS-CoV-2 variants of concern (VOCs) have diminished the effectiveness of therapeutic antibodies and vaccines. Developing a coronavirus vaccine that offers a greater breadth of protection against current and future VOCs would eliminate the need to reformulate COVID-19 vaccines. Here, we rationally engineer the sequence-conserved S2 subunit of the SARS-CoV-2 spike protein and characterize the resulting S2-only antigens. Structural studies demonstrate that the introduction of interprotomer disulfide bonds can lock S2 in prefusion trimers, although the apex samples a continuum of conformations between open and closed states...
February 20, 2024: Nature Communications
https://read.qxmd.com/read/38377340/sexual-racism-on-geosocial-networking-applications-and-identity-outness-among-sexual-minority-men-in-the-us
#15
JOURNAL ARTICLE
Junye Ma, Dafna Paltin, Michael Miller-Perusse, Ashley Black, Jason V Baker, Keith J Horvath
Although the use of geosocial networking (GSN) applications for relationship seeking is prevalent among sexual minority men (SMM), SMM of color may be vulnerable to sexual racism online. Little is known about how sexual racism relates to SMM of color's identity outness, which is integral to the minority stress model and the focus of this study. Eighty SMM, recruited through social media (53.7% racial/ethnic minority), reported their experiences of race-based discrimination on GSN apps and identity outness. Chi-squared and Fisher's tests examined differences in race-based discrimination online by participants' race/ethnicity...
February 20, 2024: Journal of Homosexuality
https://read.qxmd.com/read/38369981/humans-in-the-loop-community-science-and-machine-learning-synergies-for-overcoming-herbarium-digitization-bottlenecks
#16
JOURNAL ARTICLE
Robert Guralnick, Raphael LaFrance, Michael Denslow, Samantha Blickhan, Mark Bouslog, Sean Miller, Jenn Yost, Jason Best, Deborah L Paul, Elizabeth Ellwood, Edward Gilbert, Julie Allen
PREMISE: Among the slowest steps in the digitization of natural history collections is converting imaged labels into digital text. We present here a working solution to overcome this long-recognized efficiency bottleneck that leverages synergies between community science efforts and machine learning approaches. METHODS: We present two new semi-automated services. The first detects and classifies typewritten, handwritten, or mixed labels from herbarium sheets. The second uses a workflow tuned for specimen labels to label text using optical character recognition (OCR)...
2024: Applications in Plant Sciences
https://read.qxmd.com/read/38367882/tdp-43-m323k-causes-abnormal-brain-development-and-progressive-cognitive-and-motor-deficits-associated-with-mislocalised-and-increased-levels-of-tdp-43
#17
JOURNAL ARTICLE
Juan M Godoy-Corchuelo, Zeinab Ali, Jose M Brito Armas, Aurea B Martins-Bach, Irene García-Toledo, Luis C Fernández-Beltrán, Juan I López-Carbonero, Pablo Bascuñana, Shoshana Spring, Irene Jimenez-Coca, Ramón A Muñoz de Bustillo Alfaro, Maria J Sánchez-Barrena, Remya R Nair, Brian J Nieman, Jason P Lerch, Karla L Miller, Hande P Ozdinler, Elizabeth M C Fisher, Thomas J Cunningham, Abraham Acevedo-Arozena, Silvia Corrochano
TDP-43 pathology is found in several neurodegenerative disorders, collectively referred to as "TDP-43 proteinopathies". Aggregates of TDP-43 are present in the brains and spinal cords of >97% of amyotrophic lateral sclerosis (ALS), and in brains of ~50% of frontotemporal dementia (FTD) patients. While mutations in the TDP-43 gene (TARDBP) are usually associated with ALS, many clinical reports have linked these mutations to cognitive impairments and/or FTD, but also to other neurodegenerative disorders including Parkinsonism (PD) or progressive supranuclear palsy (PSP)...
February 15, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38360922/compact-zinc-finger-architecture-utilizing-toxin-derived-cytidine-deaminases-for-highly-efficient-base-editing-in-human-cells
#18
JOURNAL ARTICLE
Friedrich Fauser, Bhakti N Kadam, Sebastian Arangundy-Franklin, Jessica E Davis, Vishvesha Vaidya, Nicola J Schmidt, Garrett Lew, Danny F Xia, Rakshaa Mureli, Colman Ng, Yuanyue Zhou, Nicholas A Scarlott, Jason Eshleman, Yuri R Bendaña, David A Shivak, Andreas Reik, Patrick Li, Gregory D Davis, Jeffrey C Miller
Nucleobase editors represent an emerging technology that enables precise single-base edits to the genomes of eukaryotic cells. Most nucleobase editors use deaminase domains that act upon single-stranded DNA and require RNA-guided proteins such as Cas9 to unwind the DNA prior to editing. However, the most recent class of base editors utilizes a deaminase domain, DddAtox , that can act upon double-stranded DNA. Here, we target DddAtox fragments and a FokI-based nickase to the human CIITA gene by fusing these domains to arrays of engineered zinc fingers (ZFs)...
February 15, 2024: Nature Communications
https://read.qxmd.com/read/38357248/presentation-and-outcomes-of-patients-with-preoperative-critical-illness-undergoing-cardiac-surgery
#19
JOURNAL ARTICLE
Thomas S Metkus, Carlos L Alviar, Vivian M Baird-Zars, Gregory W Barsness, David D Berg, Erin A Bohula, James A Burke, Christopher B Fordyce, Jianping Guo, Jason N Katz, Ellen C Keeley, Venu Menon, P Elliott Miller, Connor G O'Brien, Shashank S Sinha, Derek So, Bradley W Ternus, Sagar Vadhar, Sean van Diepen, David A Morrow
BACKGROUND: Little is known about the prevalence and post-surgical outcomes associated with cardiac intensive care unit (CICU) therapeutics among CICU patients referred for cardiac surgery. OBJECTIVES: The purpose of this study was to investigate the clinical characteristics and outcomes of CICU patients referred for cardiac surgery from the intensive care unit. METHODS: We analyzed characteristics and outcomes of CICU admissions referred from the CICU for cardiac surgery during 2017 to 2020 across 29 centers...
March 2023: JACC Adv
https://read.qxmd.com/read/38355140/surgical-specialty-consultation-for-pediatric-facial-laceration-repair-an-american-and-canadian-survey
#20
JOURNAL ARTICLE
Andrew F Miller, Jason A Levy, Todd W Lyons
OBJECTIVE: We sought to describe patterns of and indications for surgical specialty consultation for facial laceration repair in pediatric emergency departments (PEDs). METHODS: We performed a multicenter survey of PED leadership throughout the United States and Canada evaluating the practice patterns of surgical specialty consultation for patients presenting for facial lacerations requiring repair. We measured demographics of PEDs, factors influencing the decision to obtain a surgical specialty consultation, and the presence and components of consultation guidelines...
February 14, 2024: Pediatric Emergency Care
keyword
keyword
18319
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.