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Molly cooke

Sadegh Davoudi, Chih-Ying Chin, Michael J Cooke, Roger Y Tam, Molly S Shoichet, Penney M Gilbert
Adult skeletal muscle tissue harbors the capacity for self-repair due to the presence of tissue resident muscle stem cells (MuSCs). Advances in the area of prospective MuSC isolation demonstrated the potential of cell transplantation therapy as a regenerative medicine strategy to restore strength and long-term regenerative capacity to aged, injured, or diseased skeletal muscle tissue. However, cell loss during ejection, limits to post-injection proliferation, and poor donor cell dispersion distal to the injection site are amongst hurdles to overcome to maximize MuSC transplant impact...
April 26, 2018: Biomaterials
Jeremy Lung, Laura Bell, Molly Heslop, Sophie Cuming, Anura Ariyawardana
AIM: The aim of the present study was to determine the prevalence of temporomandibular disorder (TMD) symptoms among dentistry students at James Cook University in Australia, and to determine the associations of TMD symptoms with demographic parameters and compare the prevalence to that of the Australian general population. METHODS: The study was conducted at the School of Dentistry, James Cook University. Axis I symptom questionnaire of diagnostic criteria for TMD was used to assess the prevalence of TMD symptoms...
March 31, 2018: Journal of Investigative and Clinical Dentistry
Leila Wood, Laurie Cook Heffron, Molly Voyles, Shanti Kulkarni
More than 1,800 programs exist in the United States, providing not only shelter but also transitional housing, advocacy and support, transportation, legal aid, and group and individual counseling for women who have experienced intimate partner violence (IPV). Shelter and transitional housing provide critical support for survivors, but have also been critiqued for having too many restrictive rules and code of conduct. More information is needed about the impact of rules and agency policy on women seeking services in IPV residential settings...
June 1, 2017: Journal of Interpersonal Violence
Eui Jae Sung, Masasuke Ryuda, Hitoshi Matsumoto, Outa Uryu, Masanori Ochiai, Molly E Cook, Na Young Yi, Huanchen Wang, James W Putney, Gary S Bird, Stephen B Shears, Yoichi Hayakawa
A systems-level understanding of cytokine-mediated, intertissue signaling is one of the keys to developing fundamental insight into the links between aging and inflammation. Here, we employed Drosophila , a routine model for analysis of cytokine signaling pathways in higher animals, to identify a receptor for the growth-blocking peptide (GBP) cytokine. Having previously established that the phospholipase C/Ca2+ signaling pathway mediates innate immune responses to GBP, we conducted a dsRNA library screen for genes that modulate Ca2+ mobilization in Drosophila S3 cells...
December 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
Kristen Ricchetti-Masterson, J Morel Symons, Molly Aldridge, Ayush Patel, Joe Maskell, John Logie, Yuji Yamaguchi, Suzanne F Cook
BACKGROUND: Population-based and clinical case reports of hyperhidrosis (HH) provide prevalence estimates that vary widely across reported studies because of differences in case ascertainment. OBJECTIVE: In this study, we specify diagnostic, symptom, and prescription codes for HH to estimate incidence and prevalence for the United Kingdom and the United States. METHODS: Data from UK and US health care databases were analyzed to ascertain HH cases and estimate incidence and prevalence from health care records during calendar years 2011 through 2013...
February 2018: Journal of the American Academy of Dermatology
Simone M Nicholson, Gianluca Carlesso, Lily I Cheng, Halie Cook, Karma DaCosta, Joel Leininger, Kathleen McKeever, Stephen Weasel Scott, Devon Taylor, Katie Streicher, Steve Eck, Molly Reed, Raffaella Faggioni, Ronald Herbst, Rakesh Dixit, Patricia C Ryan
MEDI-570 is a fully human afucosylated monoclonal antibody (MAb) against Inducible T-cell costimulator (ICOS), highly expressed on CD4+ T follicular helper (TFH ) cells. Effects of MEDI-570 were evaluated in an enhanced pre-postnatal development toxicity (ePPND) study in cynomolgus monkeys. Administration to pregnant monkeys did not cause any abortifacient effects. Changes in hematology and peripheral blood T lymphocyte subsets in maternal animals and infants and the attenuated infant IgG immune response to keyhole limpet hemocyanin (KLH) were attributed to MEDI-570 pharmacology...
December 2017: Reproductive Toxicology
Natalie Reznikov, Carina Phillips, Martyn Cooke, Amin Garbout, Farah Ahmed, Molly M Stevens
The normal structure of human feet is optimized for shock dampening during walking and running. Foot binding was a historical practice in China aimed at restricting the growth of female feet for aesthetic reasons. In a bound foot the shock-dampening function normally facilitated by the foot arches is withdrawn, resulting in the foot functioning as a rigid extension of the lower leg. An interesting question inspiring this study regards the nature of adaptation of the heel bone to this nonphysiological function using the parameters of cancellous bone anisotropy and 3D fabric topology and a novel intertrabecular angle (ITA) analysis...
September 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Beverly Pierce, Brandin Bowden, Molly McCullagh, Alica Diehl, Zachary Chissell, Rebecca Rodriguez, Brian M Berman, Christopher R D Adamo
CONTEXT: Physical inactivity, poor nutrition, and chronic stress threaten the health of African-American youth in urban environments. Conditions often worsen in summer with diminished access to healthy foods and safe venues for physical activity. OBJECTIVE: A public-private partnership was formed to develop and evaluate an integrative health intervention entitled "Mission Thrive Summer" (MTS). METHODS: The MTS setting was an urban farm and adjacent school in a low-income community in Baltimore, Maryland...
May 2017: Explore: the Journal of Science and Healing
Molly Cooke
No abstract text is available yet for this article.
May 1, 2017: JAMA Internal Medicine
Andrew F Leuchter, Aimee M Hunter, Felipe A Jain, Molly Tartter, Caroline Crump, Ian A Cook
Serotonin modulates brain oscillatory activity, and serotonergic projections to the thalamus and cortex modulate the frequency of prefrontal rhythmic oscillations. Changes in serotonergic tone have been reported to shift oscillations between the combined delta-theta (2.5-8 Hz) and the alpha (8-12 Hz) frequency ranges. Such frequency shifts may constitute a useful biomarker for the effects of selective serotonin reuptake inhibitor (SSRI) medications in Major Depressive Disorder (MDD). We utilized quantitative electroencephalography (qEEG) to measure shifts in prefrontal rhythmic oscillations early in treatment with either the SSRI escitalopram or placebo, and examined the relationship between these changes and remission of depressive symptoms...
January 2017: Journal of Psychiatric Research
Bethany L Stangl, Vatsalya Vatsalya, Molly R Zametkin, Megan E Cooke, Martin H Plawecki, Sean O'Connor, Vijay A Ramchandani
Background: Self-administration is a hallmark of all addictive drugs, including alcohol. Human laboratory models of alcohol self-administration have characterized alcohol-seeking behavior and served as surrogate measures of the effectiveness of pharmacotherapies for alcohol use disorders. Intravenous alcohol self-administration is a novel method that assesses alcohol exposure driven primarily by the pharmacological response to alcohol and may have utility in characterizing unique behavioral and personality correlates of alcohol-seeking and consumption...
January 1, 2017: International Journal of Neuropsychopharmacology
Molly Gabaza, Habtu Shumoy, Maud Muchuweti, Peter Vandamme, Katleen Raes
The aim of this study was to evaluate the soluble and bound phenolic content of finger millet and the impact of process induced changes on phenolic profiles of their sour porridge. Finger millet porridge and intermediate products were collected from four groups of households in the Hwedza communal area, Zimbabwe, after which soluble and bound phenolic compounds (PC) including condensed tannins (CT) were quantified. Bound PC and CT contributed 95% of the total PC and CT. The CT were only detected in the red varieties...
October 12, 2016: Journal of Agricultural and Food Chemistry
Molly C Cook, Justin Roper, Eric S Elder, Eduard Schreibmann
PURPOSE: To introduce a simplified quality assurance (QA) procedure that integrates tests for the linac's imaging components and the robotic couch. Current QA procedures for evaluating the alignment of the imaging system and linac require careful positioning of a phantom at isocenter before image acquisition and analysis. A complementary procedure for the robotic couch requires an initial displacement of the phantom and then evaluates the accuracy of repositioning the phantom at isocenter...
September 2016: Medical Physics
Nicole Green, Nadia Odell, Molly Zych, Cheryl Clark, Zong-Heng Wang, Bridget Biersmith, Clara Bajzek, Kevin R Cook, Mitchell S Dushay, Erika R Geisbrecht
The organization and stability of higher order structures that form in the extracellular matrix (ECM) to mediate the attachment of muscles are poorly understood. We have made the surprising discovery that a subset of clotting factor proteins are also essential for muscle attachment in the model organism Drosophila melanogaster One such coagulation protein, Fondue (Fon), was identified as a novel muscle mutant in a pupal lethal genetic screen. Fon accumulates at muscle attachment sites and removal of this protein results in decreased locomotor behavior and detached larval muscles...
November 2016: Genetics
Bharati Kochar, Molly Aldridge, Suzanne Follan Cook, Renee Bright, Meaghan Mallette, Heather Moniz, Samir A Shah, Neal S LeLeiko, Jason Shapiro, Bruce E Sands, Wenli Chen, Elizabeth Jaeger, Joseph Galanko, Millie D Long, Christopher F Martin, Robert S Sandler, Michael D Kappelman
BACKGROUND: Traditional cohort studies are important contributors to our understanding of inflammatory bowel diseases, but they are labor intensive and often do not focus on patient-reported outcomes. Internet-based studies provide new opportunities to study patient-reported outcomes and can be efficiently implemented and scaled. If a traditional cohort study was linked to an Internet-based study, both studies could benefit from added synergy. Existing cohort studies provide an opportunity to develop and test processes for cohort linkage...
June 3, 2016: Journal of Medical Internet Research
Kristen Ricchetti-Masterson, Molly Aldridge, John Logie, Nittaya Suppapanya, Suzanne F Cook
Recent studies on the epidemiology of the inner-ear disorder Ménière's disease (MD) use disparate methods for sample selection, case identification and length of observation. Prevalence estimates vary geographically from 17 to 513 cases per 100,000 people. We explored the impact of case detection strategies and observation periods in estimating the prevalence of MD in the USA, using data from a large insurance claims database. Using case detection strategies of ≥1, ≥2 and ≥3 ICD-9 claim codes for MD within a 1-year period, the 2012 prevalence estimates were 66, 27 and 14 cases per 100,000 people, respectively...
2016: Audiology & Neuro-otology
Molly C McLaughlin, Thomas Borch, Jens Blotevogel
Hydraulic fracturing frequently occurs on agricultural land. Yet the extent of sorption, transformation, and interactions among the numerous organic frac fluid and oil and gas wastewater constituents upon environmental release is hardly known. Thus, this study aims to advance our current understanding of processes that control the environmental fate and toxicity of commonly used hydraulic fracturing chemicals. Poly(ethylene glycol) surfactants were completely biodegraded in agricultural topsoil within 42-71 days, but their transformation was impeded in the presence of the biocide glutaraldehyde and was completely inhibited by salt at concentrations typical for oil and gas wastewater...
June 7, 2016: Environmental Science & Technology
Amir Qaseem, Devan Kansagara, Mary Ann Forciea, Molly Cooke, Thomas D Denberg
DESCRIPTION: The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on the management of chronic insomnia disorder in adults. METHODS: This guideline is based on a systematic review of randomized, controlled trials published in English from 2004 through September 2015. Evaluated outcomes included global outcomes assessed by questionnaires, patient-reported sleep outcomes, and harms. The target audience for this guideline includes all clinicians, and the target patient population includes adults with chronic insomnia disorder...
July 19, 2016: Annals of Internal Medicine
Andrew F Leuchter, Aimee M Hunter, Molly Tartter, Ian A Cook
No abstract text is available yet for this article.
December 2015: British Journal of Psychiatry: the Journal of Mental Science
Christine Kolehmainen, Anne Stahr, Anna Kaatz, Meghan Brennan, Bennett Vogelman, Jessica Cook, Molly Carnes
BACKGROUND: Internal medicine (IM) residents participate in cardiopulmonary resuscitation events (or "codes"), stressful events that involve the death or near death of patients. Experiencing traumatic stress can lead to posttraumatic stress disorder (PTSD). OBJECTIVE: We examined whether IM residents who participate in codes developed PTSD symptoms. METHODS: We conducted this research as a 2-phase, mixed methods study. In the first phase, we analyzed interview transcripts from 25 IM residents at 9 institutions for content relevant to PTSD...
September 2015: Journal of Graduate Medical Education
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