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https://www.readbyqxmd.com/read/28334811/causes-and-predictors-of-neonatal-post-neonatal-and-maternal-deaths-in-india-analysis-of-a-nationwide-district-level-household-survey-4-dlhs-4-2012-13
#1
Jaya P Tripathy, Sanskruti Mishra
Introduction: There is lack of reliable mortality estimates in India about maternal, neonatal and infant deaths. As we move towards achieving the targets under Sustainable Development Goals, information on cause of death is essential to prioritize our resources and planning. Therefore, the present study describes the causes and characteristics of neonatal, post-neonatal and maternal deaths in India. Methods: The study analysed nationwide District-Level Household Survey-4 conducted by the Ministry of Health and Family Welfare, Government of India, in 2014...
March 2, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28333155/network-analysis-a-novel-method-for-mapping-neonatal-acute-transport-patterns-in-california
#2
S N Kunz, J A F Zupancic, J Rigdon, C S Phibbs, H C Lee, J B Gould, J Leskovec, J Profit
OBJECTIVE: The objectives of this study are to use network analysis to describe the pattern of neonatal transfers in California, to compare empirical sub-networks with established referral regions and to determine factors associated with transport outside the originating sub-network. STUDY DESIGN: This cross-sectional database study included 6546 infants <28 days old transported within California in 2012. After generating a graph representing acute transfers between hospitals (n=6696), we used community detection techniques to identify more tightly connected sub-networks...
March 23, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28322867/bile-acid-analysis-in-human-disorders-of-bile-acid-biosynthesis
#3
REVIEW
Frédéric M Vaz, Sacha Ferdinandusse
Bile acids facilitate the absorption of lipids in the gut, but are also needed to maintain cholesterol homeostasis, induce bile flow, excrete toxic substances and regulate energy metabolism by acting as signaling molecules. Bile acid biosynthesis is a complex process distributed across many cellular organelles and requires at least 17 enzymes in addition to different metabolite transport proteins to synthesize the two primary bile acids, cholic acid and chenodeoxycholic acid. Disorders of bile acid synthesis can present from the neonatal period to adulthood and have very diverse clinical symptoms ranging from cholestatic liver disease to neuropsychiatric symptoms and spastic paraplegias...
March 17, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28316463/the-role-of-serotonin-transporter-in-human-lung-development-and-in-neonatal-lung-disorders
#4
E C C Castro, P Sen, W T Parks, C Langston, C Galambos
Introduction. Failure of the vascular pulmonary remodeling at birth often manifests as pulmonary hypertension (PHT) and is associated with a variety of neonatal lung disorders including a uniformly fatal developmental disorder known as alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV). Serum serotonin regulation has been linked to pulmonary vascular function and disease, and serotonin transporter (SERT) is thought to be one of the key regulators in these processes. We sought to find evidence of a role that SERT plays in the neonatal respiratory adaptation process and in the pathomechanism of ACD/MPV...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28301484/health-facility-service-availability-and-readiness-for-intrapartum-and-immediate-postpartum-care-in-malawi-a-cross-sectional-survey
#5
Naoko Kozuki, Lolade Oseni, Angella Mtimuni, Reena Sethi, Tambudzai Rashidi, Fannie Kachale, Barbara Rawlins, Shivam Gupta
This analysis seeks to identify strengths and gaps in the existing facility capacity for intrapartum and immediate postpartum fetal and neonatal care, using data collected as a part of Malawi's Helping Babies Breath program evaluation. From August to September 2012, the Maternal and Child Health Integrated Program (MCHIP) conducted a cross-sectional survey in 84 Malawian health facilities to capture current health facility service availability and readiness and health worker capacity and practice pertaining to labor, delivery, and immediate postpartum care...
2017: PloS One
https://www.readbyqxmd.com/read/28300011/neonatal-fatty-acid-profiles-are-correlated-with-infant-growth-measures-at-6-months
#6
P F O'Tierney-Ginn, D Davina, M Gillingham, D J P Barker, C Morris, K L Thornburg
Rapid weight gain in infancy and low levels of n-3 long chain polyunsaturated fatty acids (LCPUFA) at birth are associated with increased adiposity later in life. The association between placental LCPUFA delivery and weight gain in infancy is poorly understood. We sought to determine the relationships between maternal phenotype, placental fatty acid transporter expression and offspring growth patterns over the first 6 months. Placental tissue and cord blood were collected at term delivery from women with uncomplicated pregnancies...
March 16, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28298198/maternal-and-neonatal-service-usage-and-determinants-in-fragile-and-conflict-affected-situations-a-systematic-review-of-asia-and-the-middle-east
#7
Saji S Gopalan, Ashis Das, Natasha Howard
BACKGROUND: Fragile and conflict-affected situations (FCS) in Asia and the Middle-East contribute significantly to global maternal and neonatal deaths. This systematic review explored maternal and neonatal health (MNH) services usage and determinants in FCS in Asia and the Middle-East to inform policy on health service provision in these challenging settings. METHODS: This systematic review was conducted using a standardised protocol. Pubmed, Embase, Web of Science, and selected development agency websites were searched for studies meeting inclusion criteria...
March 15, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28294399/the-impact-of-italian-regionalisation-on-transporting-neonatal-patients-back-from-the-neonatal-intensive-care-unit-to-the-referring-level-two-unit
#8
Carlo Bellini, Luca A Ramenghi
Perinatal regionalisation networks aim to centralise highly skilled care for high-risk neonates and their mothers (1). This study examined how the regional policy in Liguria, Italy, had changed the management of very low birth weight preterm infants. We were particularly keen to look at the impact on back transports, namely transferring patients back to a Level II unit once they did not need to be in the neonatal intensive care unit (NICU) at the IRCCS Istituto Giannina Gaslini, Genoa, Italy. This article is protected by copyright...
March 10, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28289928/human-rotavirus-strain-wa-downregulates-nhe1-and-nhe6-expressions-in-rotavirus-infected-caco-2-cells
#9
Honglang Chen, Lijun Song, Guixian Li, Wenfeng Chen, Shumin Zhao, Ruoxia Zhou, Xiaoying Shi, Zhenying Peng, Wenchang Zhao
Rotavirus (RV) is the most common cause of severe gastroenteritis and fatal dehydration in human infants and neonates of different species. However, the pathogenesis of rotavirus-induced diarrhea is poorly understood. Secretory diarrhea caused by rotavirus may lead to a combination of excessive secretion of fluid and electrolytes into the intestinal lumen. Fluid absorption in the small intestine is driven by Na(+)-coupled transport mechanisms at the luminal membrane, including Na(+)/H(+) exchanger (NHE). Here, we performed qRT-PCR to detect the transcription of NHEs...
March 13, 2017: Virus Genes
https://www.readbyqxmd.com/read/28278217/passive-hypothermia-%C3%A2-35-36%C3%A2-c-during-transport-of-newborns-with-hypoxic-ischaemic-encephalopathy
#10
Aurélie Sellam, Noëlla Lode, Azzedine Ayachi, Gilles Jourdain, Stéphane Dauger, Peter Jones
BACKGROUND: Hypothermia initiated in the first six hours of life in term infants with hypoxic ischemic encephalopathy reduces the risk of death and severe neurological sequelae. Our study's principal objective was to evaluate transport predictors potentially influencing arrival in NICU (Neonatal Intensive Care Unit) at a temperature ≥35-<36°C. METHODOLOGY/PRINCIPAL FINDINGS: A multi-centric, prospective cohort study was conducted during 18 months by the three Neonatal Transport Teams and 13 NICUs...
2017: PloS One
https://www.readbyqxmd.com/read/28271797/term-infants-born-at-home-in-peru-are-less-likely-to-be-hospitalised-in-the-neonatal-period-than-those-born-in-hospital
#11
Tina Lavin, David B Preen
BACKGROUND: More than 50% of women worldwide give birth at home, but little is known about home birth and subsequent neonatal hospitalisation. OBJECTIVES: The objective of the study was to investigate home birth and neonatal hospitalisation of term neonates in Peru. METHODS: The relationship between birth setting [home - with or without skilled birth attendant (SBA), health centre, hospital] and neonatal hospitalisation (n = 1656) and incubator care (n = 1651) was investigated using data from the 2002 Young Lives Study...
March 8, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28264506/plasma-membrane-na%C3%A2-%C2%BA-coupled-citrate-transporter-slc13a5-and-neonatal-epileptic-encephalopathy
#12
REVIEW
Yangzom D Bhutia, Jonathan J Kopel, John J Lawrence, Volker Neugebauer, Vadivel Ganapathy
SLC13A5 is a Na⁺-coupled transporter for citrate that is expressed in the plasma membrane of specific cell types in the liver, testis, and brain. It is an electrogenic transporter with a Na⁺:citrate(3-) stoichiometry of 4:1. In humans, the Michaelis constant for SLC13A5 to transport citrate is ~600 μM, which is physiologically relevant given that the normal concentration of citrate in plasma is in the range of 150-200 μM. Li⁺ stimulates the transport function of human SLC13A5 at concentrations that are in the therapeutic range in patients on lithium therapy...
February 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28260772/neonatal-transport-experience-of-a-tertiary-care-hospital-of-bangladesh
#13
S K Dey, S Sharker, I Jahan, S C Moni, K H Shabuj, M J Chisti, M A Mannan, M Shahidullah
Safe transportation is mostly an unnoticed neonatal health issue in Bangladesh and no documentation is available regarding the existing practices. So this study was intended to document transport status of the referred newborn to a tertiary care hospital. This observational study included 150 out born neonates over 12 months period transported from various places to NICU, Bangabandhu Sheikh Mujib Medical University (BSMMU) from May 2015 to April 2016. A structured data collection form was used to record information categorized into pre-transport, during transport and at admission...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28259932/albumin-based-nanoparticles-as-methylprednisolone-carriers-for-targeted-delivery-towards-the-neonatal-fc-receptor-in-glomerular-podocytes
#14
Lin Wu, Mingyu Chen, Huijuan Mao, Ningning Wang, Bo Zhang, Xiufen Zhao, Jun Qian, Changying Xing
Glucocorticoids (GCs) are commonly used in the treatment of nephrotic syndrome. However, high doses and long periods of GC therapy can result in severe side effects. The present study aimed to selectively deliver albumin‑methylprednisolone (MP) nanoparticles towards glomerular podocytes, which highly express the specific neonatal Fc receptor (FcRn) of albumin. Bovine serum albumin (BSA) was labeled with a fluorescent dye and linked with modified MP via an amide bond. The outcome nanoparticle named BSA633‑MP showed a uniform size with a diameter of approximately 10 nm and contained 12 drug molecules on average...
February 21, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28258294/profiling-of-virulence-determinants-in-cronobacter-sakazakii-isolates-from-different-plant-and-environmental-commodities
#15
Niharika Singh, Mamta Raghav, Shifa Narula, Simran Tandon, Gunjan Goel
Cronobacter sakazakii is an emerging pathogen causing meningitis, sepsis and necrotizing enterocolitis in neonates and immune-compromised adults. The present study describes the profiling of different virulence factors associated with C. sakazakii isolates derived from plant-based materials and environmental samples (soil, water, and vacuum dust). All the isolates exhibited β-hemolysis and chitinase activity, and were able to utilize inositol. Among the nine virulence-associated genes, hly gene coding for hemolysin was detected in all the isolates followed by ompA (outer membrane protein); however, plasmid-borne genes were detected at a level of 60% for both cpa (cronobacter plasminogen activator) and eitA (Ferric ion transporter protein) gene, respectively...
March 3, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28255779/mutations-in-slc25a22-hyperprolinaemia-vacuolated-fibroblasts-and-presentation-with-developmental-delay
#16
Emma S Reid, Hywel Williams, Glenn Anderson, Malika Benatti, Kling Chong, Chela James, Louise Ocaka, Cheryl Hemingway, Daniel Little, Richard Brown, Alasdair Parker, Simon Holden, Emma Footitt, Shamima Rahman, Paul Gissen, Philippa B Mills, Peter T Clayton
Mutations in SLC25A22 are known to cause neonatal epileptic encephalopathy and migrating partial seizures in infancy. Using whole exome sequencing we identified four novel SLC25A22 mutations in six children from three families. Five patients presented clinical features similar to those in the literature including hypotonia, refractory neonatal-onset seizures and developmental delay. However, the sixth patients presented atypically with isolated developmental delay, developing late-onset (absence) seizures only at 7 years of age...
March 2, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28245682/-hypothermia-treatment-in-asphyxiated-neonates-a-single-center-experience-in-hungary
#17
Kata Kovács, Enikő Szakmár, Ünőke Méder, Márton Kolossváry, Zsolt Bagyura, Lilla Lamboy, Zsuzsanna Élő, Attila Szabó, Miklós Szabó, Ágnes Jermendy
INTRODUCTION AND AIM: We aimed to analyze patient characteristics of term neonates with hypoxic-ischemic encephalopathy treated with hypothermia at the 3rd level Neonatal Intensive Care Unit of the 1st Department of Pediatrics, Semmelweis University. METHOD: We conducted a retrospective cohort analysis between 2013-2015, including 97 asphyxiated neonates with HIE who received hypothermia treatment, using our in-house developed novel registry database. RESULTS: 59...
March 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28241728/ampk-%C3%AE-ketoglutarate-axis-regulates-intestinal-water-and-ion-homeostasis-in-young-pigs
#18
Liuqin He, Niu Huang, Huan Li, Junquan Tian, Xihong Zhou, Tiejun Li, Kang Yao, Guoyao Wu, Yulong Yin
Water and ion absorption via sensitive aquaporins (AQPs) and ion channels is of critical importance in intestinal health. However, whether α-ketoglutarate (AKG) could improve intestinal water and ion homeostasis in lipopolysaccharide (LPS)-challenged piglets and whether the AMP-activated protein kinase (AMPK) pathway is involved remains largely unknown. This study was conducted to investigate the effect of dietary AKG supplementation on the small intestinal water and ion homeostasis through modulating the AMPK pathway in a piglet diarrhea model...
March 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28238468/the-effects-of-unilateral-cochlear-ablation-on-the-expression-of-vesicular-glutamate-transporter-1-in-the-lower-auditory-pathway-of-neonatal-rats
#19
Hiroki Hasegawa, Miyako Hatano, Hisashi Sugimoto, Makoto Ito, Hiroshi Kawasaki, Tomokazu Yoshizaki
OBJECTIVES: Unilateral cochlear damage has profound effects on the central auditory pathways in the brain. METHODS: We examined the effects of unilateral cochlear ablation on VGLUT1 expression in the cochlear nucleus (CN) and the superior olivary complex (SOC) in neonatal rats. RESULTS: VGLUT1 expression in the CN subdivisions (the AVCN, the PVCN and the DCN-deep layers) and the SOC (the MnTB, the LSO and the MSO) ipsilateral to the ablated side was significantly suppressed by unilateral cochlear ablation...
February 23, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28230106/longitudinal-assessments-of-normal-and-perilesional-tissues-in-focal-brain-ischemia-and-partial-optic-nerve-injury-with-manganese-enhanced-mri
#20
Kevin C Chan, Iris Y Zhou, Stanley S Liu, Yolandi van der Merwe, Shu-Juan Fan, Victor K Hung, Sookja K Chung, Wu-Tian Wu, Kwok-Fai So, Ed X Wu
Although manganese (Mn) can enhance brain tissues for improving magnetic resonance imaging (MRI) assessments, the underlying neural mechanisms of Mn detection remain unclear. In this study, we used Mn-enhanced MRI to test the hypothesis that different Mn entry routes and spatiotemporal Mn distributions can reflect different mechanisms of neural circuitry and neurodegeneration in normal and injured brains. Upon systemic administration, exogenous Mn exhibited varying transport rates and continuous redistribution across healthy rodent brain nuclei over a 2-week timeframe, whereas in rodents following photothrombotic cortical injury, transient middle cerebral artery occlusion, or neonatal hypoxic-ischemic brain injury, Mn preferentially accumulated in perilesional tissues expressing gliosis or oxidative stress within days...
February 23, 2017: Scientific Reports
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