keyword
https://read.qxmd.com/read/38532461/placental-tlr-recognition-of-salivary-and-subgingival-microbiota-is-associated-with-pregnancy-complications
#1
JOURNAL ARTICLE
Kazune Pax, Nurcan Buduneli, Murat Alan, Pinar Meric, Onder Gurlek, Shareef M Dabdoub, Purnima S Kumar
BACKGROUND: Pre-term birth, the leading cause of neonatal mortality, has been associated with maternal periodontal disease and the presence of oral pathogens in the placenta. However, the mechanisms that underpin this link are not known. This investigation aimed to identify the origins of placental microbiota and to interrogate the association between parturition complications and immune recognition of placental microbial motifs. Video Abstract METHODS: Saliva, plaque, serum, and placenta were collected during 130 full-term (FT), pre-term (PT), or pre-term complicated by pre-eclampsia (PTPE) deliveries and subjected to whole-genome shotgun sequencing...
March 26, 2024: Microbiome
https://read.qxmd.com/read/38526217/ongoing-effects-of-preterm-birth-on-the-dopaminergic-and-noradrenergic-pathways-in-the-frontal-cortex-and-hippocampus-of-guinea-pigs
#2
JOURNAL ARTICLE
Roisin A Moloney, Hannah K Palliser, Rebecca M Dyson, Carlton L Pavy, Max Berry, Jonathon J Hirst, Julia C Shaw
Children born preterm have an increased likelihood of developing neurobehavioral disorders such as attention-deficit hyperactivity disorder (ADHD) and anxiety. These disorders have a sex bias, with males having a higher incidence of ADHD, whereas anxiety disorder tends to be more prevalent in females. Both disorders are underpinned by imbalances to key neurotransmitter systems, with dopamine and noradrenaline in particular having major roles in attention regulation and stress modulation. Preterm birth disturbances to neurodevelopment may affect this neurotransmission in a sexually dimorphic manner...
March 25, 2024: Developmental Neurobiology
https://read.qxmd.com/read/38524098/neighborhood-environment-and-poor-maternal-glycemic-control-associated-complications-of-gestational-diabetes-mellitus
#3
JOURNAL ARTICLE
Leela V Thomas, Claudine T Jurkovitz, Zugui Zhang, Mitchell R Fawcett, M James Lenhard
INTRODUCTION: Risk of complications due to gestational diabetes mellitus is increasing in the U.S., particularly among individuals from racial minorities. Research has focused largely on clinical interventions to prevent complications, rarely on individuals' residential environments. This retrospective cohort study aims to examine the association between individuals' neighborhoods and complications of gestational diabetes mellitus. METHODS: Demographic and clinical data were extracted from electronic health records and linked to American Community Survey data from the U...
June 2024: AJPM Focus
https://read.qxmd.com/read/38517098/amino-acid-uptake-limitations-during-human-mesenchymal-stem-cell-based-chondrogenesis
#4
JOURNAL ARTICLE
Yi Zhong, Bo Zhang, Rodrigo A Somoza, Arnold I Caplan, Jean F Welter, Harihara Baskaran
Amino acids are the essential building block for collagen and proteoglycan, which are the main constituents for cartilage extracellular matrix (ECM). Synthesis of ECM proteins require uptake of various essential/non-essential amino acids. Analyzing amino acids metabolism during chondrogenesis can help to relate tissue quality to amino acids metabolism under different conditions. In our study, we studied amino acids uptake/secretion using hMSC-based aggregate chondrogenesis in a serum-free induction medium with a defined chemical formulation...
March 22, 2024: Tissue Engineering. Part A
https://read.qxmd.com/read/38515025/sex-and-fetal-genome-influence-gene-expression-in-pig-endometrium-at-the-end-of-gestation
#5
JOURNAL ARTICLE
Agnes Bonnet, Lisa Bluy, Laure Gress, Laurianne Canario, Laure Ravon, Aurelie Sécula, Yvon Billon, Laurence Liaubet
BACKGROUND: A fine balance of feto-maternal resource allocation is required to support pregnancy, which depends on interactions between maternal and fetal genetic potential, maternal nutrition and environment, endometrial and placental functions. In particular, some imprinted genes have a role in regulating maternal-fetal nutrient exchange, but few have been documented in the endometrium. The aim of this study is to describe the expression of 42 genes, with parental expression, in the endometrium comparing two extreme breeds: Large White (LW); Meishan (MS) with contrasting neonatal mortality and maturity at two days of gestation (D90-D110)...
March 21, 2024: BMC Genomics
https://read.qxmd.com/read/38514168/skin-to-skin-stabilisation-and-uninterrupted-respiratory-support-for-preterm-infants-after-birth-feasibility-of-a-new-and-simplified-rpap-system
#6
JOURNAL ARTICLE
Sonja Baldursdottir, Kolbrun Gunnarsdottir, Snorri Donaldsson, Baldvin Jonsson, Thomas Drevhammar
BACKGROUND: The rPAP respiratory support system, used for delivery room stabilisation with nasal prongs, has been shown to reduce the need for intubation in extremely preterm infants. A simplified version of the system has been developed. The purpose of this study was to determine the feasibility of providing uninterrupted respiratory support with the simplified rPAP from birth up to 4 hours of life and to assess ease of use for skin-to skin stabilisation. METHODS: This was a non-randomised feasibility study conducted at Karolinska University Hospital, Sweden...
March 21, 2024: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://read.qxmd.com/read/38512678/intranasal-nose-to-brain-drug-delivery-via-the-olfactory-region-in-mice-two-in-depth-protocols-for-region-specific-intranasal-application-of-antibodies-and-for-expression-analysis-of-fc-receptors-via-in-situ-hybridization-in-the-nasal-mucosa
#7
JOURNAL ARTICLE
Helena Herzog, Sara Glöckler, Johannes Flamm, Simone Ladel, Frank Maigler, Claudia Pitzer, Katharina Schindowski
A region-specific catheter-based intranasal administration method was successfully developed, established, and validated as reported previously. By using this method, drugs can be applicated specifically to the olfactory region. Thereby, intranasally administered drugs could be delivered via neuronal connections to the central nervous system. Here, we present a detailed protocol with a step-by-step procedure for nose-to-brain delivery via the olfactory mucosa.Fc receptors such as the neonatal Fc receptor (FcRn) and potentially Fcγ receptor IIb (FcγRIIb) are involved in the uptake and transport of antibodies via the olfactory nasal mucosa...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38504758/contributory-factors-to-early-neonatal-deaths-in-the-upper-east-regional-hospital-in-ghana
#8
JOURNAL ARTICLE
Francis K Wuni, Margaret W Kukeba, Yakubu Zakariah, Emmanuella A Nyaabila, Aiden S Saanwie
OBJECTIVE: This study examined factors identified during early neonatal death audits contributing to preventable newborn deaths at the Upper East Regional Hospital. METHOD: Data for this study was collected retrospectively from perinatal death audit forms using three data collectors. Data collection lasted two weeks, from 18th June to 2nd July 2021. The data collectors submitted 113 filled hard copy data collection forms. This was then entered into a designed Excel sheet and exported to STATA software version 15...
June 2023: Ghana Medical Journal
https://read.qxmd.com/read/38493982/neuroligin1-in-excitatory-synapses-contributes-to-long-term-cognitive-impairments-after-repeated-neonatal-sevoflurane-exposures
#9
JOURNAL ARTICLE
Hui Zhang, Yingqiao Niu, Peng Yuan, Wenbo Liu, Wei Zhu, Jie Sun
BACKGROUND: Repeated sevoflurane exposures in neonatal rats may lead to neuronal apoptosis affecting long-term cognitive function, the mechanism is unknown. Neuroligin1 (NL1) is essential for normal excitatory transmission and long-term synaptic plasticity in the hippocampus of intact animals. Herein, we explore the role of NL1 in hippocampal excitatory synapses on long-term cognitive impairments induced by repeated sevoflurane exposures in neonatal rats. METHODS: From postnatal day six (P6) to P8, neonatal rats were exposed to 30% oxygen or 3% sevoflurane +30% oxygen for 2 h daily...
March 15, 2024: Experimental Neurology
https://read.qxmd.com/read/38492913/motivations-for-and-against-participation-in-neonatal-research-insights-from-interviews-of-diverse-parents-approached-for-neonatal-research-in-the-us
#10
JOURNAL ARTICLE
Elliott Mark Weiss, Pamela K Donohue, Susan H Wootton, Emily Stevens, Stephanie L Merhar, Mihai Puia-Dumitrescu, Amanda Mercer, Ellie Oslin, Kathryn M Porter, Benjamin S Wilfond
OBJECTIVE: To describe parents' motivations for and against participation in neonatal research, including the views of those who declined participation. STUDY DESIGN: We performed 44 semi-structured, qualitative interviews of parents approached for neonatal research. Here we describe their motivations for and against participation. RESULTS: Altruism was an important reason parents chose to participate. Some hoped participation in research would benefit their infant...
March 14, 2024: Journal of Pediatrics
https://read.qxmd.com/read/38490776/vibratory-impact-of-3-different-ambulance-suspension-systems-on-the-simulated-neonate-and-health-care-provider-during-normal-driving-conditions
#11
JOURNAL ARTICLE
Trevor Pier, Justin S Misuraca, Maria J Mandt
OBJECTIVE: Patients and health care providers experience varying degrees of vibration during interfacility ground transport. The impact of vibration on term and preterm neonates may result in physiologic instability and increased risk of intracranial hemorrhage, whereas the impact on health care providers has been shown to include an increase in perceived and physiologic stress levels and may contribute to chronic back and neck pain. This study aimed to evaluate 3 common ambulance suspension systems and the corresponding vibratory impact produced during typical interfacility driving conditions on adult caregiver and neonatal patient mannequins...
2024: Air Medical Journal
https://read.qxmd.com/read/38487530/fcry-is-a-key-molecule-controlling-maternal-blood-igy-transfer-to-yolks-during-egg-development-in-avian-species
#12
JOURNAL ARTICLE
Mayuko Okamoto, Ryo Sasaki, Koki Ikeda, Kasumi Doi, Fumiya Tatsumi, Kenzi Oshima, Takaaki Kojima, Shusei Mizushima, Keisuke Ikegami, Takashi Yoshimura, Kyohei Furukawa, Misato Kobayashi, Fumihiko Horio, Atsushi Murai
Maternal immunoglobulin transfer plays a key role in conferring passive immunity to neonates. Maternal blood immunoglobulin Y (IgY) in avian species is transported to newly-hatched chicks in two steps: 1) IgY is transported from the maternal circulation to the yolk of maturing oocytes, 2) the IgY deposited in yolk is transported to the circulation of the embryo via the yolk sac membrane. An IgY-Fc receptor, FcRY, is involved in the second step, but the mechanism of the first step is still unclear. We determined whether FcRY was also the basis for maternal blood IgY transfer to the yolk in the first step during egg development...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38486324/air-transportation-impact-on-a-late-preterm-neonate
#13
JOURNAL ARTICLE
Sheng-Ping Li, Po-Chang Hsu, Chuang-Yen Huang, Po-Wei Wu, Hung-Hsiang Fang
BACKGROUND: Neonatal air transportation is a crucial means of moving critically ill or sick neonates to specialized neonatal intensive care units or medical centers for consultation, regardless of distance or geographical limits. Proper preparation and consideration of air transport can help alleviate medical emergencies and ensure safe delivery. However, crewmembers and neonates may face stress during transportation. To date, there are few studies on neonatal air transportation in Taiwan. CASE REPORT: We present the case of a late preterm neonate born with neonatal respiratory distress syndrome and polycythemia, who was also diagnosed with patent ductus arteriosus and mild pulmonary arterial hypertension on echocardiography...
April 1, 2024: Aerospace Medicine and Human Performance
https://read.qxmd.com/read/38482260/do-gene-polymorphisms-play-a-role-in-newborn-hyperbilirubinemia
#14
JOURNAL ARTICLE
N Hakan, M Aydin, S Ceylaner, D Dilli, A Zenciroğlu, N Okumuş
OBJECTIVES: Polymorphisms of the uridine-diphospho-glucuronosyltransferase 1A1 ( UGT1A1 ) gene, hepatic solute carrier organic anion transporter 1B1/B3 ( SLCO1B1/3 ) gene, and glutathione S-transferase ( GST ) gene have been associated with significant hyperbilirubinemia in some populations. This study aims to determine whether the variation of UGT1A1 , SLCO1B1/3 and GST genes play an important role in neonatal hyperbilirubinemia in Turkish newborn infants. METHODS: The study included 61 idiopathic hyperbilirubinemia cases, 28 prolonged jaundice cases, and 41 controls...
December 2023: Balkan Journal of Medical Genetics: BJMG
https://read.qxmd.com/read/38469845/smooth-roads-ahead-lessons-from-our-sick-neonate-retrieval-service
#15
JOURNAL ARTICLE
Zubair Ahmad Bhat, Mohamed Muneer Varikkottil, Femitha Pournami, Ajai Kumar Prithvi, Naveen Jain
Strategies for free transfer of sick neonates to hospitals are in place, but reports suggest suboptimal status of the same across the country. Over 7 years, our Sick Neonate Retrieval Service (SNRS) transported 165 neonates, of whom 92.1% survived. Safe, stable transportation mandates the presence of a neonatology-trained doctor and nurse in an equipped ambulance.
March 15, 2024: Indian Pediatrics
https://read.qxmd.com/read/38467191/endothelial-slc35a1-deficiency-causes-loss-of-lsec-identity-and-exacerbates-neonatal-lipid-deposition-in-the-liver-in-mice
#16
JOURNAL ARTICLE
Bin Zuo, Fei Yang, Lulu Huang, Jingjing Han, Tianyi Li, Zhenni Ma, Lijuan Cao, Yun Li, Xia Bai, Miao Jiang, Yang He, Lijun Xia
BACKGROUND & AIMS: The functional maturation of the liver largely occurs after birth. In the early stages of life, the liver of a newborn encounters enormous high-fat metabolic stress caused by the consumption of breast milk. It is unclear how the maturing liver adapts to high lipid metabolism. Liver sinusoidal endothelial cells (LSECs) play a fundamental role in establishing liver vasculature and are decorated with many glycoproteins on their surface. The Slc35a1 gene encodes a CMP-sialic acid transporter responsible for transporting CMP-sialic acids between the cytoplasm and the Golgi apparatus for protein sialylation...
March 9, 2024: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/38460800/neonatal-hypoxia-impairs-serotonin-release-and-cognitive-functions-in-adult-mice
#17
JOURNAL ARTICLE
Karen K Y Lee, Bidisha Chattopadhyaya, Antônia Samia Fernandes do Nascimento, Luc Moquin, Pedro Rosa-Neto, Bénédicte Amilhon, Graziella Di Cristo
Children who experienced moderate perinatal asphyxia (MPA) are at risk of developing long lasting subtle cognitive and behavioral deficits, including learning disabilities and emotional problems. The prefrontal cortex (PFC) regulates cognitive flexibility and emotional behavior. Neurons that release serotonin (5-HT) project to the PFC, and compounds modulating 5-HT activity influence emotion and cognition. Whether 5-HT dysregulations contribute to MPA-induced cognitive problems is unknown. We established a MPA mouse model, which displays recognition and spatial memory impairments and dysfunctional cognitive flexibility...
March 7, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38460573/physiologically-based-pharmacokinetic-modeling-and-dosing-optimization-of-cefotaxime-in-preterm-and-term-neonates
#18
JOURNAL ARTICLE
Qiaoxi Li, Yanping Guan, Chen Xia, Lili Wu, Hongyu Zhang, Yan Wang
BACKGROUND: Cefotaxime is commonly used in treating bacterial infections in neonates. To characterize the pharmacokinetic process in neonates and evaluate different recommended dosing schedules of cefotaxime, a physiologically-based pharmacokinetic (PBPK) model of cefotaxime was established in adults and scaled to neonates. METHODS: A whole-body PBPK model was built in PK-SIM® software. Three elimination pathways are composed of enzymatic metabolism in the liver, passive filtration through glomerulus, and active tubular secretion mediated by renal transporters...
March 7, 2024: Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38455980/placental-efflux-transporters-and-antiseizure-or-antidepressant-medication-use-impact-birth-weight-in-moba-cohort
#19
JOURNAL ARTICLE
Marta H Hernandez, Jacqueline M Cohen, Karoline H Skåra, Thea K Grindstad, Yunsung Lee, Per Magnus, Pål R Njølstad, Ole A Andreassen, Elizabeth C Corfield, Alexandra Havdahl, Espen Molden, Kari Furu, Maria C Magnus, Alvaro Hernaez
Low birth weight raises neonatal risks and lifelong health issues and is linked to maternal medication use during pregnancy. We examined data from the Norwegian Mother, Father, and Child Cohort Study and the Medical Birth Registry of Norway, including 69,828 offspring with genotype data and 81,189 with maternal genotype data. We identified genetic risk variants in placental efflux transporters, calculated genetic scores based on alleles related to transporter activity, and assessed their interaction with prenatal use of antiseizure or antidepressant medication on offspring birth weight...
March 15, 2024: IScience
https://read.qxmd.com/read/38455643/neonatal-transport-practices-and-effectiveness-of-the-use-of-low-cost-interventions-on-outcomes-of-transported-neonates-in-sub-saharan-africa-a-systematic-review-and-narrative-synthesis
#20
JOURNAL ARTICLE
Emmanuel Okai, Frankie Fair, Hora Soltani
BACKGROUND AND AIMS: Neonatal deaths contribute significantly to under-5 mortality worldwide with Sub-Saharan Africa (SSA) alone accounting for 43% of global newborn deaths. Significant challenges in the region's health systems evidenced by huge disparities in health facility deliveries and poor planning for preterm births are major contributors to the high neonatal mortality. Many neonates in the region are delivered in suboptimal conditions and require transportation to facilities equipped for specialized care...
March 2024: Health Science Reports
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