Marta H Hernandez, Jacqueline M Cohen, Karoline H Skåra, Thea K Grindstad, Yunsung Lee, Per Magnus, Pål R Njølstad, Ole A Andreassen, Elizabeth C Corfield, Alexandra Havdahl, Espen Molden, Kari Furu, Maria C Magnus, Alvaro Hernaez
Low birth weight raises neonatal risks and lifelong health issues and is linked to maternal medication use during pregnancy. We examined data from the Norwegian Mother, Father, and Child Cohort Study and the Medical Birth Registry of Norway, including 69,828 offspring with genotype data and 81,189 with maternal genotype data. We identified genetic risk variants in placental efflux transporters, calculated genetic scores based on alleles related to transporter activity, and assessed their interaction with prenatal use of antiseizure or antidepressant medication on offspring birth weight...
March 15, 2024: IScience