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Partial nephrectomy

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https://www.readbyqxmd.com/read/29679000/valsartan-alleviates-insulin-resistance-in-skeletal-muscle-of-chronic-renal-failure-rats
#1
Yang Wang, Ri-Bao Wei, Yue Yang, Ting-Yu Su, Meng-Jie Huang, Ping Li, Xiang-Mei Chen
BACKGROUND Studies on insulin resistance (IR) in chronic kidney disease (CKD) patients are rare, and its exact mechanism remains unclear. In this study, we explored the molecular mechanism of IR with chronic renal failure (CRF) and interventions to alleviate IR in patients with CRF. MATERIAL AND METHODS In vivo and in vitro models of CRF were established by 5/6 nephrectomy and urea stimulation C2C12 cells, respectively. Based on the CRF model, angiotensin II (Ang II) and valsartan groups were established to observe the effect of drug intervention on IR...
April 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29678662/multi-institutional-survival-analysis-of-incidental-pathologic-t3a-upstaging-in-clinical-t1-renal-cell-carcinoma-following-partial-nephrectomy
#2
Christopher M Russell, Amir H Lebastchi, Juan Chipollini, Adam Niemann, Rohit Mehra, Todd M Morgan, David C Miller, Ganesh S Palapattu, Khaled S Hafez, Wade J Sexton, Philippe E Spiess, Alon Z Weizer
OBJECTIVE: To evaluate whether incidental pT3a upstaging after partial nephrectomy (PN) for cT1 disease results in inferior oncologic outcomes compared to pT1a/b disease. METHODS: Retrospective chart review was completed at the University of Michigan and Moffitt Cancer Center to identify patients undergoing PN for cT1 masses between 1995-2015. A total of 1955 patients were identified, of which 95 had pT3a upstaging. Median follow-up was 38.2 months. Patients with pT3a disease were individually matched by clinico-pathologic features with patients undergoing PN with pT1a/b disease in a 1:2 ratio...
April 17, 2018: Urology
https://www.readbyqxmd.com/read/29677895/re-intravenous-mannitol-versus-placebo-during-partial-nephrectomy-in-patients-with-normal-kidney-function-a-double-blind-clinically-integrated-randomized-trial
#3
https://www.readbyqxmd.com/read/29677868/re-renal-functional-outcomes-in-patients-undergoing-percutaneous-cryoablation-or-partial-nephrectomy-for-a-solitary-renal-mass
#4
Jeffrey A Cadeddu
No abstract text is available yet for this article.
May 2018: Journal of Urology
https://www.readbyqxmd.com/read/29675631/role-of-quantitative-computed-tomography-texture-analysis-in-the-prediction-of-adherent-perinephric-fat
#5
Zine-Eddine Khene, Karim Bensalah, Axel Largent, Shahrokh Shariat, Gregory Verhoest, Benoit Peyronnet, Oscar Acosta, Renaud DeCrevoisier, Romain Mathieu
OBJECTIVE: To assess the performance of computed tomography (CT) texture analysis to predict the presence of adherent perinephric fat (APF). MATERIALS AND METHODS: Seventy patients with small renal tumors treated with robot-assisted partial nephrectomy were included. Patients were divided into two groups according to the presence of APF. We extracted 15 image features from unenhanced CT and contrast-enhanced CT corresponding to first-order and second-order Haralick textural features...
April 19, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29671904/prospective-study-of-robotic-partial-nephrectomy-for-renal-cancer-in-japan-comparison-with-a-historical-control-undergoing-laparoscopic-partial-nephrectomy
#6
Kazushi Tanaka, Jun Teishima, Atsushi Takenaka, Ryoichi Shiroki, Yasuyuki Kobayashi, Kazunori Hattori, Hiro-Omi Kanayama, Shigeo Horie, Yasushi Yoshino, Masato Fujisawa
OBJECTIVES: To evaluate the outcomes of robotic partial nephrectomy compared with those of laparoscopic partial nephrectomy for T1 renal tumors in Japanese centers. METHODS: Patients with a T1 renal tumor who underwent robotic partial nephrectomy were eligible for inclusion in the present study. The primary end-point consisted of three components: a negative surgical margin, no conversion to open or laparoscopic surgery and a warm ischemia time ≤25 min. We compared data from these patients with the data from a retrospective study of laparoscopic partial nephrectomy carried out in Japan...
April 19, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29668695/value-of-computed-tomography-texture-analysis-for-prediction-of-perioperative-complications-during-laparoscopic-partial-nephrectomy-in-patients-with-renal-cell-carcinoma
#7
Georg Bier, Simone Bier, Malte Niklas Bongers, Ahmed Othman, Ulrike Ernemann, Johann-Martin Hempel
PURPOSE: Tumorous texture is a marker for tumor tissue inhomogeneity. Based on this assumption, this study aims to evaluate the value of computed tomography texture analysis for imaging-based prediction of perioperative complications during laparoscopic partial tumor nephrectomy. METHODS: A total of 106 patients with histologically confirmed renal cell carcinoma and pre-operative CT were included and volumetric texture analysis of the tumors was performed by two readers...
2018: PloS One
https://www.readbyqxmd.com/read/29668402/retroperitoneal-laparoscopic-partial-nephrectomy-versus-radical-nephrectomy-for-clinical-t1-renal-hilar-tumor-comparison-of-perioperative-characteristics-and-short-term-functional-and-oncologic-outcomes
#8
Chuance Yang, Zhenlong Wang, Shanlong Huang, Li Xue, Delai Fu, Tie Chong
PURPOSE: To present our single-center experience with retroperitoneal laparoscopic partial nephrectomy (LPN) and retroperitoneal laparoscopic radical nephrectomy (LRN) for T1 renal hilar tumors and evaluate which one is better. METHODS: A retrospective review of 63 patients with hilar tumors undergoing retroperitoneal LPN or LRN was performed. The perioperative characteristics, change in estimated glomerular filtration rate (eGFR) from baseline to month 3, and oncologic outcomes were summarized...
April 18, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29664692/comparison-of-short-term-functional-oncological-and-perioperative-outcomes-between-laparoscopic-and-robotic-partial-nephrectomy-beyond-the-learning-curve
#9
Quentin Alimi, Benoit Peyronnet, Philippe Sebe, Jean-François Cote, Solene-Florence Kammerer-Jacquet, Zine-Eddine Khene, Benjamin Pradere, Romain Mathieu, Gregory Verhoest, Bertrand Guillonneau, Karim Bensalah
PURPOSE: To compare the short-term outcomes of robot-assisted partial nephrectomy (RPN) and laparoscopic partial nephrectomy (LPN) when performed by highly experienced surgeons. METHODS: A prospective multicenter study was conducted, including the 50 last patients having undergone LPN and RPN for T1-T2 renal tumors in two institutions between 2013 and 2016, performed by two different surgeons with an experience of over 200 procedures each in LPN and RPN, respectively, at the beginning of the study...
April 17, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29663528/purely-off-clamp-robotic-partial-nephrectomy-preliminary-3-year-oncological-and-functional-outcomes
#10
Giuseppe Simone, Leonardo Misuraca, Gabriele Tuderti, Francesco Minisola, Mariaconsiglia Ferriero, Giuseppe Romeo, Manuela Costantini, Samer F Al-Rawashdah, Salvatore Guaglianone, Michele Gallucci
OBJECTIVES: To describe our surgical technique and to report perioperative, 3-year oncological and functional outcomes of a single-center series of purely off-clamp robotic partial nephrectomy. METHODS: A prospective renal cancer institutional database was queried, and data of consecutive patients treated with purely off-clamp robotic partial nephrectomy between 2010 and 2015 in a high-volume center were collected. Perioperative complications, and 3-year oncological and functional outcomes were assessed...
April 16, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29661179/outcomes-of-pathologic-stage-t3a-renal-cell-carcinoma-up-staged-from-small-renal-tumor-emphasis-on-partial-nephrectomy
#11
Hakmin Lee, Minseung Lee, Sang Eun Lee, Seok-Soo Byun, Hyeon Hoe Kim, Cheol Kwak, Sung Kyu Hong
BACKGROUND: The prognosis of patients with pathologic stage T3a renal cell carcinoma (RCC) that is up-staged from a small renal tumor remains controversial. We evaluated the prognosis of patients with RCC who were up-staged from clinical stage T1 to pathologic stage T3a. METHODS: We retrospectively reviewed the data of 3431 patients who were surgically treated for clinical stage T1 RCC. The survival outcomes were compared using Kaplan-Meier and Cox proportional analyses...
April 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29660398/molecular-phenotypes-of-the-human-kidney-myoid-stromal-cells-telocytes-and-myoepithelial-cells
#12
M C Rusu, L Mogoantă, F Pop, M A Dobra
The connective stromal and epithelial compartments of the kidney have regenerative potential and phenotypic flexibility. A few studies have shown that cells appertaining to both compartments can exhibit myoid phenotypes. The purpose of our study was to investigate the myoid pattern of kidney and its association with the kidney niches containing stromal cells/telocytes (SC/TCs). We performed an immunohistochemical study using a panel of endothelial, myoid, mesenchymal and stem/progenitor markers, namely CD31, CD34, CD105 (endoglin), CD117/c-kit, nestin, desmin, α-smooth muscle actin (α-SMA) and the heavy chain of smooth muscle myosin (SMM)...
April 13, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29657088/monocarboxylate-transporters-mct1-and-mct4-are-independent-prognostic-biomarkers-for-the-survival-of-patients-with-clear-cell-renal-cell-carcinoma-and-those-receiving-therapy-targeting-angiogenesis
#13
Yan-Wei Cao, Yong Liu, Zhen Dong, Lei Guo, En-Hao Kang, Yong-Hua Wang, Wei Zhang, Hai-Tao Niu
BACKGROUND: Prognostic biomarkers for patients with clear cell renal cell carcinoma (ccRCC), particularly those receiving therapy targeting angiogenesis, are not well established. In this study, we examined the correlations of monocarboxylate transporter 1 (MCT1) and MCT4, 2 critical transporters for glycolytic metabolism, with various clinicopathological parameters as well as survival of patients with ccRCC and those treated with vascular endothelial growth factor receptor (VEGFR) inhibitors...
April 12, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29653161/is-routine-use-of-renal-tumor-biopsy-associated-with-lower-rates-of-benign-histology-following-nephrectomy-for-small-renal-masses
#14
Patrick O Richard, Luke T Lavallée, Frederic Pouliot, Maria Komisarenko, Lisa Martin, Jean-Baptiste Latouff, Antonio Finelli
PURPOSE: Renal tumor biopsies (RTBs) have been proposed as a management alternative to avoid treatment of benign or low-risk small renal masses (SRMs). However, many urologists are reluctant to recommend RTB because they feel its result frequently will not impact management. Our primary objective was to evaluate if centers that routinely favor RTB (FRB) have lower rates of benign histology after surgery than centers that use a selective RTB approach (SRB). METHODS: This was a retrospective multicenter study of patients who underwent a partial or radical nephrectomy for a lesion suspicious for localised RCC and measuring ≤4cm (cT1a and pT1a or pT3a) between 2013 and 2015...
April 10, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29649832/the-impact-of-preexisting-chronic-kidney-disease-on-the-severity-and-recovery-of-acute-kidney-injury
#15
Sung Yoon Lim, Yoon Sook Ko, Hee Young Lee, Ji Hyun Yang, Myung Gyu Kim, Sang Kyung Jo, Won Yong Cho
BACKGROUND: Recent observational studies have shown that in chronic kidney disease (CKD) patients, a significantly smaller percentage of patients with an episode of acute kidney injury (AKI) have full recovery of renal function compared to those without CKD. However, precise mechanisms involved in the incomplete repair after AKI with preexisting CKD have not been completely ascertained. Here, we assessed the impact of preexisting CKD on the severity and recovery of AKI in a mouse model of 5/6 nephrectomy...
April 12, 2018: Nephron
https://www.readbyqxmd.com/read/29648703/editorial-comment-to-robot-assisted-laparoscopic-partial-nephrectomy-versus-laparoscopic-partial-nephrectomy-a-propensity-score-matched-comparative-analysis-of-surgical-outcomes-and-preserved-renal-parenchymal-volume
#16
Rocco Papalia, Riccardo Mastroianni
No abstract text is available yet for this article.
April 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29645344/functional-and-oncologic-outcomes-of-open-laparoscopic-and-robotic-partial-nephrectomy-a-multicenter-comparative-matched-pair-analyses-with-a-median-5-years-follow-up
#17
Ki Don Chang, Ali Abdel Raheem, Kwang Hyun Kim, Cheol Kyu Oh, Sung Yul Park, Young Sik Kim, Won Sik Ham, Woong Kyu Han, Young Deuk Choi, Byung Ha Chung, Koon Ho Rha
PURPOSE: Data regarding the long-term oncologic and functional outcomes of robotic-assisted, laparoscopic, and open partial nephrectomy (RPN, LPN and OPN) is lacking. Our aim was to compare outcomes among RPN, LPN and OPN with a 5-year median follow-up. PATIENTS AND METHODS: We retrospectively analyzed 1308 patients who underwent PN (RPN, n=380; LPN, n=206; OPN, n=722) between 2006 and 2012 at four academic centers. We performed 1:1:1 propensity score matching adjustment based on confounding variables among groups and 366 patients (122 in each group) were included in the final analysis...
April 12, 2018: BJU International
https://www.readbyqxmd.com/read/29628300/long-term-outcomes-of-selective-renal-artery-embolization-for-renal-arteriovenous-fistulae-with-dilated-venous-sac
#18
Yasushi Kimura, Keigo Osuga, Yusuke Ono, Tetsuro Nakazawa, Hiroki Higashihara, Noriyuki Tomiyama
PURPOSE: To retrospectively evaluate the role of selective renal artery embolization for renal arteriovenous fistulae (AVFs) with dilated venous sac. MATERIALS AND METHODS: Between 2002 and 2015, 14 patients (7 men and 7 women; mean age, 60 years) with a single renal AVF with dilated venous sac underwent selective renal artery embolization. Three patients presented with gross hematuria, 4 presented with occult blood in urine, and 1 presented with chronic heart failure...
April 6, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29626285/image-guided-minimally-invasive-treatment-for-small-renal-cell-carcinoma
#19
REVIEW
Miltiadis E Krokidis, Panagiotis Kitrou, Stavros Spiliopoulos, Dimitrios Karnabatidis, Konstantinos Katsanos
Surgical partial nephrectomy is still considered as the "gold standard" for the definitive management of small malignant renal masses, whereas treatment with image-guided percutaneous ablation is still mainly reserved for those patients who cannot undergo nephron-sparing surgical resection due to advanced age, underlying comorbidities or compromised renal function. Nonetheless, the recent evidence that underlines the long-term oncological equipoise of percutaneous ablation methods with surgical resection in combination with the reduced complication rate and cost supports the use of an image-guided minimally invasive approach as a first-line treatment...
April 6, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29620517/solitary-fibrous-tumor-of-the-kidney-treated-with-laparoscopic-partial-nephrectomy-a-case-report
#20
Xing Chen, Jian-Feng Wang, Zhen-Shan Ding, Xiao-Feng Zhou
We herein reported a 27-year-old woman with a right renal mass for two years. She underwent laparoscopic partial nephrectomy. Immunohistochemical examination of the specimen confirmed the diagnosis of solitary fibrous tumor by revealing its positive staining for cluster of differentiation (CD)34, epithelial membrane antigen (EMA), B-cell lymphoma-2 (Bcl-2) and CD99 in the tumor cells. No adjuvant treatment was carried out. The patient was in good health without local recurrence or metastasis during 2 years of follow-up...
March 30, 2018: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
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