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https://www.readbyqxmd.com/read/29215340/a-report-of-brugada-syndrome-presenting-with-cardiac-arrest-triggered-by-verapamil-intoxication
#1
Kahraman Yakut, İlkay Erdoğan, Birgül Varan, İlyas Atar
BACKGROUND: Brugada syndrome is a disease characterized by a specific electrocardiographic pattern and an increased risk of sudden cardiac death. We present this case with the updated literature to emphasise the need to consider the diagnosis of Brugada syndrome in patients admitted to the emergency ward with sudden cardiac arrest. CASE REPORT: A 16-year-old female patient was admitted to the emergency ward with complaints of weakness and abdominal pain, and she had four cardiac arrests during her evaluation period...
December 1, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29207769/brugada-syndrome-with-spontaneous-fluctuation-in-ecg-pattern
#2
Abhishek Goyal, Varun Loomba, Naved Aslam, Bishav Mohan, Gurpreet Singh Wander
No abstract text is available yet for this article.
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29202755/h558r-a-common-scn5a-polymorphism-modifies-the-clinical-phenotype-of-brugada-syndrome-by-modulating-dna-methylation-of-scn5a-promoters
#3
Hiroya Matsumura, Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Shunsuke Tomomori, Chikaaki Motoda, Michitaka Amioka, Naoya Hironobe, Masaaki Toshishige, Shinya Takahashi, Katsuhiko Imai, Taijiro Sueda, Kazuaki Chayama, Yasuki Kihara
BACKGROUND: A common SCN5A polymorphism H558R (c.1673 A > G, rs1805124) improves sodium channel activity in mutated channels and known to be a genetic modifier of Brugada syndrome patients (BrS). We investigated clinical manifestations and underlying mechanisms of H558R in BrS. METHODS AND RESULTS: We genotyped H558R in 100 BrS (mean age 45 ± 14 years; 91 men) and 1875 controls (mean age 54 ± 18 years; 1546 men). We compared clinical parameters in BrS with and without H558R (H558R+ vs...
December 4, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29196089/atrial-fibrillation-ablation-with-the-second-generation-cryoballoon-multicenter-propensity-score-matched-comparison-between-freezing-strategies
#4
Erwin Ströker, Kaspars Kupics, Carlo de Asmundis, Giacomo Mugnai, Valentina de Regibus, Jeroen De Cocker, Dirk Stockman, Saverio Iacopino, Juan Sieira-Moret, Pedro Brugada, Bruno Schwagten, Yves De Greef, Gian-Battista Chierchia
BACKGROUND: Second generation cryoballoon (CB-A) ablation is highly effective in achieving pulmonary vein (PV) isolation and freedom from atrial fibrillation (AF). However, the ideal freezing strategy is still under debate. Our objective was to investigate the efficacy and outcome between different freezing strategies used with the CB-A in a multicenter, matched population. METHODS: From a total cohort of 1018 patients having undergone CB-A ablation for drug-refractory AF, 673 patients with follow-up ≥6months were included and stratified according to the applied freezing strategy: bonus freeze (BF) versus single freeze (SF)...
November 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29182748/phrenic-nerve-injury-during-right-inferior-pulmonary-vein-ablation-with-the-second-generation-cryoballoon-clinical-procedural-and-anatomical-characteristics
#5
Juan-Pablo Abugattas, Carlo de Asmundis, Saverio Iacopino, Francesca Salghetti, Ken Takarada, Hugo-Enrique Coutiño, Erwin Ströker, Valentina De Regibus, Yves de Greef, Pedro Brugada, Juan Sieira, Gian-Battista Chierchia
Aims: There is still sparse information regarding phrenic nerve injury (PNI) during ablation of the right inferior pulmonary vein (RIPV) by means of the second-generation cryoballoon advance (CB-A). The aim of this study was to describe the procedural, anatomical, and clinical characteristics of patients who experienced PNI during the RIPV ablation. Methods and results: Consecutive patients who had undergone pulmonary vein isolation (PVI) using CB-A and suffered PNI during RIPV ablation were retrospectively included in our study...
November 22, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29180267/cardiac-arrest-and-brugada-syndrome-is-drug-induced-type-1-ecg-pattern-always-a-marker-of-low-risk
#6
Pietro Delise, Giuseppe Allocca, Nadir Sitta, Federico Migliore, Federica Dagradi, Carla Spazzolini, Luigi Sciarra, Valeria Carinci, Domenico Corrado, Leonardo Calò, Peter J Schwartz
BACKGROUND: Patients diagnosed as affected by Brugada syndrome (BrS) on the basis of a drug-induced type 1 ECG pattern (type1) are regarded as at low risk for cardiac arrest. We tested whether this assumption matches reality. METHODS: The study population included 26 patients from our group and 217 patients from three studies published between 2002 and 2013, all of them with aborted cardiac arrest (ACA) and in whom a previously unrecognized type1 (spontaneous or drug-induced) was discovered after the event, thus leading to the diagnosis of BrS...
November 16, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29174707/brugada-phenocopy-associated-with-diabetic-ketoacidosis-in-two-pediatric-patients
#7
Ryan E Alanzalon, Jonathan R Burris, Jeffrey M Vinocur
Two patients without cardiac history demonstrated type 1 Brugada pattern during hospitalization for diabetic ketoacidosis (DKA). Both patients had normalization of their ECGs after treatment of marked electrolyte abnormalities and metabolic acidosis. In this report, we describe two cases of Brugada phenocopy associated with DKA in children.
October 28, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29174247/atrial-electrical-abnormality-in-patients-with-brugada-syndrome-assessed-by-signal-averaged-electrocardiography
#8
Yasutsugu Nagamoto, Yuto Fujii, Yuichi Morita, Yusuke Ueda, Yasuko Miyake, Kenichi Yamane, Mai Fujiwara, Shinji Mito, Yuichiro Watari, Hiromichi Tamekiyo, Tomokazu Okimoto, Yuji Muraoka, Yasuhiko Hayashi
BACKGROUND: Ventricular fibrillation and atrial fibrillation are well-known arrhythmias in patients with Brugada syndrome. This study evaluated the characteristics of the atrial arrhythmogenic substrate using the signal-averaged electrogram (SAECG) in patients with Brugada syndrome. METHODS: SAECGs were performed during normal sinus rhythm in 23 normal volunteers (control group), 21 patients with paroxysmal atrial fibrillation (PAF; PAF group), and 21 with Brugada syndrome (Brugada group)...
November 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29174097/effects-of-propofol-on-ventricular-repolarization-and-incidence-of-malignant-arrhythmias-in-adults
#9
Alexander Wutzler, Carlo De Asmundis, Hisao Matsuda, Marwin Bannehr, Lena Loehr, Katharina Voelk, Johannes Jungmann, Martin Huemer, Philipp Attanasio, Abdul Parwani, Leif-Hendrik Boldt, Pedro Brugada, Wilhelm Haverkamp
BACKGROUND: Propofol is commonly used for procedural sedation in interventional electrophysiology. However, ventricular arrhythmias under Propofol have been reported. Our aim was to investigate ventricular repolarization and incidence of ventricular arrhythmias under Propofol infusion in adults with cardiac arrhythmias. METHODS: QRS, QTcB (Bazett), QTcFri (Fridericia), JTc, measurement of T peak to Tend time (Tp-e) at baseline and under Propofol infusion was performed in 235 patients...
November 11, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29173400/channelopathies-as-causes-of-sudden-cardiac-death
#10
REVIEW
Peter J Schwartz, Michael J Ackerman, Arthur A M Wilde
This article reviews the main clinical aspects of 3 channelopathies: the long QT syndrome, the catecholaminergic polymorphic ventricular tachycardia, and the Brugada syndrome. The text summarizes our views on clinical presentation and diagnosis, on risk stratification, and on therapy. Special attention is given to the progress in the understanding of the genetic bases and on the growing impact of genetics on therapy, which, at least in the case of long QT syndrome, now allows gene-specific management.
December 2017: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/29172153/ajmaline-blocks-ina-and-ikr-without-eliciting-differences-between-brugada-syndrome-patient-and-control-human-pluripotent-stem-cell-derived-cardiac-clusters
#11
Duncan C Miller, Stephen C Harmer, Ariel Poliandri, Muriel Nobles, Elizabeth C Edwards, James S Ware, Tyson V Sharp, Tristan R McKay, Leo Dunkel, Pier D Lambiase, Andrew Tinker
The class Ia anti-arrhythmic drug ajmaline is used clinically to unmask latent type I ECG in Brugada syndrome (BrS) patients, although its mode of action is poorly characterised. Our aims were to identify ajmaline's mode of action in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs), and establish a simple BrS hiPSC platform to test whether differences in ajmaline response could be determined between BrS patients and controls. Control hiPSCs were differentiated into spontaneously contracting cardiac clusters...
November 7, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29163198/ankyrins-and-spectrins-in-cardiovascular-biology-and-disease
#12
REVIEW
Mona M El Refaey, Peter J Mohler
Ankyrins are adaptor proteins critical for the expression and targeting of cardiac membrane proteins, signaling molecules, and cytoskeletal elements. Findings in humans and animal models have highlighted the in vivo roles for ankyrins in normal physiology and in cardiovascular disease, most notably in cardiac arrhythmia. For example, human ANK2 loss-of-function variants are associated with a complex array of electrical and structural phenotypes now termed "ankyrin-B syndrome," whereas alterations in the ankyrin-G pathway for Nav channel targeting are associated with human Brugada syndrome...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29159074/only-some-patients-with-bulbar-and-spinal-muscular-atrophy-may-develop-cardiac-disease
#13
Josef Finsterer, Claudia Stöllberger
Objectives: According to recent publications, some patients with spinal and bulbar muscular atrophy (BSMA) develop cardiac disease, manifesting as ST-segment abnormalities, Brugada-syndrome, dilative cardiomyopathy, or sudden cardiac death. Here we present neurological and cardiac data of a BSMA patient who was followed up for 10 y. Case report: In a male patient aged 47 y, BSMA was diagnosed at age 37 y upon the typical clinical presentation (postural tremor since age 12 y, dysarthria since age 15 y, muscle cramps since age 29 y, general myalgias since age 32 y, general fasciculations since age 34 y, myoclonic jerks, easy fatigability, dyspnea upon exercise since age 36 y) and a CAG-repeat expansion of 47 ± 1 repeats in the androgen-receptor gene detected at age 37 y...
March 2018: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/29150410/lung-function-in-early-adulthood-and-health-in-later-life-a-transgenerational-cohort-analysis
#14
Alvar Agustí, Guillaume Noell, Josep Brugada, Rosa Faner
BACKGROUND: Early life events can affect health in later life. We hypothesised that low lung function (FEV1 <80% predicted) in early adulthood (25-40 years) is associated with higher prevalence and earlier incidence of respiratory, cardiovascular, and metabolic abnormalities, and premature death. METHODS: In this cohort analysis, we tested this hypothesis using data from the Framingham Offspring Cohort (FOC) and validated our observations in CARDIA (an independent cohort) and GenIII (which includes the direct descendants of FOC participants)...
November 14, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29148067/should-theophylline-be-added-to-the-j-wave-syndrome-therapeutic-armamentarium
#15
EDITORIAL
Charles Antzelevitch, Sami Viskin
The substrate for both early repolarization syndrome (ERS) and Brugada syndrome (BrS), the so-called J wave syndromes, has been shown to develop as a consequence of genetic variants causing a loss of function of inward currents such sodium (INa ) and calcium (ICa ) channel currents or a gain of function in outward currents such as the transient outward current (Ito ). These changes in ion channel function result in an outward shift of the balance of currents active during the early phases of the epicardial action potential in the right ventricular outflow tract (RVOT) of the heart in the case BrS and in the inferior left ventricle in the case of ERS...
November 16, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29145303/epicardial-radiofrequency-catheter-ablation-of-brugada-syndrome-with-electrical-storm-during-ventricular-fibrillation-a-case-report
#16
Shufen Jiang, Xiaomeng Yin, Chang Dong, Yunlong Xia, Jinqiu Liu
RATIONALE: Brugada syndrome (BrS) is characterized by ST segment elevation at the J point ≥2 mm in the right precordial electrocardiogram (ECG) leads, in the absence of structural heart disease, electrolyte disturbances, or ischemia. It is a well-described cause of sudden death in young patients, especially in the age of between 30 and 40 years old. Here, we reported an unusual case of electrical storm (ES) of ventricular fibrillation (VF) caused by BrS with complete right bundle-branch block (CRBBB) in a 75-year-old male patient...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29142189/a-carbamazepine-induced-brugada-type-electrocardiographic-pattern-in-a-patient-with-schizophrenia
#17
Hisanobu Ota, Yuichiro Kawamura, Nobuyuki Sato, Naoyuki Hasebe
We report the case of a 61-year-old man with schizophrenia who was treated with carbamazepine, in whom electrocardiography showed transient Brugada-type ST elevation. He had been hospitalized our hospital's Department of Psychiatry and had been diagnosed with pneumonia. On the following day, electrocardiography showed coved-type ST elevation in the right precordial leads and a blood examination revealed that the patient's carbamazepine concentration was at the upper limit of the standard range, as well as hypothyroidism...
2017: Internal Medicine
https://www.readbyqxmd.com/read/29138889/-hypothermia-induced-ecg-changes-characteristic-but-not-specific
#18
G Michels, S Ney, F Hoffmann, J Brugada, R Pfister, K Brockmeier, A Sultan
Hypothermia-induced J‑ or so-called Osborn waves can be detected under therapeutic hypothermia in approximately 20-40% of cases. The occurrence of J‑waves in the context of the targeted temperature management after cardiopulmonary resuscitation is characteristic, but not pathognomonic for hypothermia. An electrocardiographic diagnosis under hypothermia after cardiac arrest should always be done with caution due to the various hypothermia-associated electromechanical changes of the myocardium.
November 14, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29133531/unusual-st-segment-elevation-in-the-anterolateral-precordial-leads-ischemia-brugada-phenocopy-brugada-syndrome-all-or-none
#19
Andrés Ricardo Pérez-Riera, Raimundo Barbosa-Barros, Rodrigo Daminello-Raimundo, Luiz Carlos de Abreu, Adrian Baranchuk
No abstract text is available yet for this article.
November 14, 2017: Circulation
https://www.readbyqxmd.com/read/29112729/single-freeze-per-vein-strategy-with-the-second-generation-cryoballoon-for-atrial-fibrillation-a-propensity-score-matched-study-between-180-and-240-s-application-time-in-a-large-cohort-of-patients
#20
Valentina De Regibus, Juan-Pablo Abugattas, Saverio Iacopino, Giacomo Mugnai, Cesare Storti, Giulio Conte, Angelo Auricchio, Erwin Ströker, Hugo-Enrique Coutiño, Ken Takarada, Francesca Salghetti, Ian Lusoc, Lucio Capulzini, Pedro Brugada, Carlo de Asmundis, Gian-Battista Chierchia
Aims: The single-freeze strategy using the second-generation cryoballoon (CB-A, Arctic Front Advance, Medtronic, Minneapolis, MN, USA) has been reported to be as effective as the recommended double-freeze approach in several single-centre studies. In this retrospective, international, multicentre study, we compare the 3-min single-freeze strategy with the 4-min single-freeze strategy. Methods and results: Four hundred and thirty-two patients having undergone pulmonary vein isolation (PVI) by means of CB-A using a single-freeze strategy were considered for this analysis...
November 2, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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