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Anat Milman, Jean-Baptiste Gourraud, Antoine Andorin, Pieter G Postema, Frederic Sacher, Philippe Mabo, Giulio Conte, Carla Giustetto, Georgia Sarquella-Brugada, Aviram Hochstadt, Sung-Hwan Kim, Jimmy Jm Juang, Shingo Maeda, Yoshihide Takahashi, Tsukasa Kamakura, Takeshi Aiba, Eran Leshem, Yoav Michowitz, Michael Rahkovich, Yuka Mizusawa, Elena Arbelo, Zhengrong Huang, Isabelle Denjoy, Yanushi D Wijeyeratne, Carlo Napolitano, Ramon Brugada, Ruben Casado-Arroyo, Jean Champagne, Leonardo Calo, Jacob Tfelt-Hansen, Silvia G Priori, Masahiko Takagi, Christian Veltmann, Pietro Delise, Domenico Corrado, Elijah R Behr, Fiorenzo Gaita, Gan-Xin Yan, Josep Brugada, Antoine Leenhardt, Arthur A M Wilde, Pedro Brugada, Kengo F Kusano, Kenzo Hirao, Gi-Byoung Nam, Vincent Probst, Bernard Belhassen
BACKGROUND: There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVES: To compare clinical, electrocardiographic (ECG), electrophysiologic (EP) and genetic characteristics between males and females in BrS-patients with their first AE. METHODS: The multicenter Survey on AE in BrS (SABRUS) collected data on first AE in 678 BrS-patients including 619 (91.3%) males and 59 (8...
June 13, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Michele Cavalli, Barbara Fossati, Raffaele Vitale, Elisa Brigonzi, Vito A G Ricigliano, Lorenzo Saraceno, Rosanna Cardani, Carlo Pappone, Giovanni Meola
Skeletal muscle sodium channelopathies are a group of neuromuscular disorders associated with mutations in the SCN4A gene. Because principal sodium channel isoforms expressed in the skeletal muscles and the heart are distinct one from the other, this condition usually spares cardiac functioning. Nonetheless, evidence on a possible link between skeletal muscle and cardiac sodium channelopathies has emerged in recent years. To date, eight patients bearing pathogenetic mutations in the SCN4A gene and manifesting cardiac electrophysiological alterations have been reported in literature...
2018: Frontiers in Neurology
Stefan Warpechowski Neto, Tiago Luiz Luz Leiria, Laura Lessa Gaudie Ley, Antonio Lessa Gaudie Ley, Luiza Zwan Dutra, Leonardo Martins Pires, Marcelo Lapa Kruse, Gustavo Glotz de Lima
BACKGROUND: Brugada syndrome (SBr) is an arrhythmic condition characterized by ST-T segment abnormalities in the right precordial leads associated with a high risk of ventricular arrhythmias and sudden death. Local data regarding the clinical characteristics of patients with a typical electrocardiographic (ECG) pattern undergoing electrophysiological study are scarce. OBJECTIVE: To evaluate patients with an ECG pattern suggestive of SBr referred for electrophysiological evaluation in a specialized center...
June 11, 2018: Arquivos Brasileiros de Cardiologia
Dursun Aras, Ozcan Ozeke, Serkan Cay, Firat Ozcan, Burak Acar, Serkan Topaloglu
No abstract text is available yet for this article.
June 8, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Masahiko Takagi, Yukio Sekiguchi, Yasuhiro Yokoyama, Naohiko Aihara, Masayasu Hiraoka, Kazutaka Aonuma
No abstract text is available yet for this article.
June 8, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Xin Hui S Chan, Yan Naung Win, Laura J Mawer, Jireh Y Tan, Josep Brugada, Nicholas J White
BACKGROUND: Dihydroartemisinin-piperaquine is an effective and well tolerated artemisinin-based combination therapy that has been assessed extensively for the prevention and treatment of malaria. Piperaquine, similar to several structurally related antimalarials currently used, can prolong cardiac ventricular repolarisation duration and the electrocardiographic QT interval, leading to concerns about its proarrhythmic potential. We aimed to assess the risk of potentially lethal iatrogenic ventricular arrhythmias in individuals receiving dihydroartemisinin-piperaquine...
June 7, 2018: Lancet Infectious Diseases
Aleix Fort, Pablo Loma-Osorio, Óscar Alcalde, Ramon Brugada
No abstract text is available yet for this article.
June 7, 2018: Medicina Clínica
Josep Brugada, Gerhard Hindricks
No abstract text is available yet for this article.
June 1, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Ibrahim El-Battrawy, Martin Borggrefe, Siegfried Lang, Xiaobo Zhou, Ibrahim Akin
No abstract text is available yet for this article.
June 1, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Dimitrios Asvestas, Gary Tse, Adrian Baranchuk, George Bazoukis, Tong Liu, Athanasios Saplaouras, Panagiotis Korantzopoulos, Christina Goga, Michael Efremidis, Antonios Sideris, Konstantinos P Letsas
Several clinical, electrocardiographic (ECG) and electrophysiological markers have been proposed to provide optimal risk stratification in patients with Brugada syndrome (BrS). Of the different markers, only a spontaneous type 1 ECG pattern has clearly shown a sufficiently high predictive value. This review article highlights specific ECG markers based on depolarization and/or repolarization that have been associated with an increased risk of arrhythmic events in patients with BrS.
March 2018: IJC Heart & Vasculature
C A Martin, M Orini, N T Srinivasan, J Bhar-Amato, S Honarbakhsh, A W Chow, M D Lowe, R Ben-Simon, P M Elliott, P Taggart, P D Lambiase
BACKGROUND: The re-entry vulnerability index (RVI) is a recently proposed activation-repolarization metric designed to quantify tissue susceptibility to re-entry. This study aimed to test feasibility of an RVI-based algorithm to predict the earliest endocardial activation site of ventricular tachycardia (VT) during electrophysiological studies and occurrence of haemodynamically significant ventricular arrhythmias in follow-up. METHODS: Patients with Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) (n = 11), Brugada Syndrome (BrS) (n = 13) and focal RV outflow tract VT (n = 9) underwent programmed stimulation with unipolar electrograms recorded from a non-contact array in the RV...
May 20, 2018: International Journal of Cardiology
José M Di Diego, Charles Antzelevitch
The J wave syndromes, including the Brugada (BrS) and early repolarization (ERS) syndromes, are characterized by the manifestation of prominent J waves in the electrocardiogram appearing as an ST segment elevation and the development of life-threatening cardiac arrhythmias. BrS and ERS differ with respect to the magnitude and lead location of abnormal J waves and are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes (JWS). Despite over 25 years of intensive research, risk stratification and the approach to therapy of these two inherited cardiac arrhythmia syndromes are still rapidly evolving...
June 5, 2018: Pacing and Clinical Electrophysiology: PACE
Mark Heckle, Shadwan Alsafwah, Manyoo Agarwal
No abstract text is available yet for this article.
June 1, 2018: JAMA Internal Medicine
Shiva Sreenivasan, Monica Monaghan, Adrian Baranchuk
No abstract text is available yet for this article.
June 1, 2018: JAMA Internal Medicine
Javier García-Niebla, Antonio Bayés de Luna, Adrian Baranchuk
No abstract text is available yet for this article.
June 1, 2018: JAMA Internal Medicine
Christian Abrahim, Satish Maharaj
Case presentation: A 47-year-old Caucasian woman with type 1 diabetes presented with epigastric pain and vomiting. She had not been adherent with her diet and insulin therapy for the past 3 weeks. She never had a personal or family history of arrhythmia-related symptoms, ventricular tachycardia or fibrillation (VT/VF) or premature sudden cardiac death (SCD). Examination revealed dry mucosa, tachycardia and epigastric tenderness to palpation. Her ECG showed ST elevations (V1-V3) with associated T wave inversions (figure 1A)...
2018: Heart Asia
Giselle G Gervacio, Jaime Alfonso Manalo Aherrera, Rody G Sy, Lauro L Abrahan Iv, Michael Joseph Agbayani, Felix Eduardo Punzalan, Elmer Jasper B Llanes, Paul Ferdinand M Reganit, Olivia T Sison, E Shyong Tai, Felicidad V Velandria, Allan Gumatay, Nina T Castillo-Carandang
Background: Brugada syndrome is the mechanism for sudden unexplained death. The Brugada ECG pattern is found in 2% of Filipinos. There is a knowledge gap on the clinical outcome of these individuals. The clinical profile and 5-year cardiac event rate of individuals with the Brugada ECG pattern were determined in this cohort. Methods: This is a sub-study of LIFECARE (Life Course Study in Cardiovascular Disease Epidemiology), a community based cohort enrolling healthy individuals 20 to 50 years old conducted in 2009-2010...
2018: Heart Asia
Eva M Benito, Nuno Cabanelas, Marta Nuñez-Garcia, Francisco Alarcón, Rosa M Figueras I Ventura, David Soto-Iglesias, Eduard Guasch, Susanna Prat-Gonzalez, Rosario J Perea, Roger Borràs, Constantine Butakoff, Oscar Camara, Felipe Bisbal, Elena Arbelo, José Maria Tolosana, Josep Brugada, Antonio Berruezo, Lluís Mont
Aims: Left atrial (LA) fibrosis can be identified by late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) in patients with atrial fibrillation (AF). However, there is limited information about anatomical fibrosis distribution in the left atrium. The aim is to determine whether there is a preferential spatial distribution of fibrosis in the left atrium in patients with AF. Methods and results: A 3-Tesla LGE-CMR was performed in 113 consecutive patients referred for AF ablation...
May 31, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Adedoyin Akinlonu, Ranjit Suri, Priyanka Yerragorla, Persio D López, Tuoyo O Mene-Afejuku, Olatunde Ola, Carissa Dumancas, Jumana Chalabi, Gerald Pekler, Ferdinand Visco, Savi Mushiyev
Recreational drugs are commonly abused in all age groups. Intoxication with these substances can induce silent but significant electrocardiographic signs which may lead to sudden death. In this case study, we present a 49-year-old male with no medical comorbidities who came to the emergency department requesting opioid detoxification. Toxicology screen was positive for cocaine, heroin, and cannabis. Initial electrocardiogram (EKG) showed features of a Brugada pattern in the right precordial leads, which resolved within one day into admission...
2018: Case Reports in Cardiology
Rene M Kukkamalla, Eric Katz
No abstract text is available yet for this article.
May 2018: Clinical practice and cases in emergency medicine
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