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https://www.readbyqxmd.com/read/27909531/brugada-syndrome-risk-stratification-and-management
#1
REVIEW
Konstantinos P Letsas Md Fesc, Stamatis Georgopoulos Md, Konstantinos Vlachos Md, Nikolaos Karamichalakis Md, Ioannis Liatakis Md, Panagiotis Korantzopoulos Md PhD, Tong Liu Md PhD, Michael Efremidis Md, Antonios Sideris Md
The Brugada syndrome (BrS) is an arrhythmogenic disease associated with an increased risk of ventricular fibrillation and sudden cardiac death. The risk stratification and management of BrS patients, particularly of asymptomatic ones, still remains challenging. A previous history of aborted sudden cardiac death or arrhythmic syncope in the presence of spontaneous type 1 ECG pattern of BrS phenotype appear to be the most reliable predictors of future arrhythmic events. Several other ECG parameters have been proposed for risk stratification...
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909514/influence-of-novel-electrocardiographic-features-of-provocable-brugada-ecg-in-arrhythmogenic-cardiomyopathy-and-its-exclusion-by-lead-avr
#2
REVIEW
Stefan Peters
In 19 patients (14 females, mean age 49.1 ± 11.3 years) with typical arrhythmogenic cardiomyopathy and provocable type I Brugada ECG pattern by ajmaline administration were analysed by novel electrocardiographic features as having "true" or "false" Brugada syndrome. Three patients turned out as having false Brugada syndrome, the diagnosis is pure arrhythmogenic cardiomyopathy. In 16 patients, however, true Brugada syndrome could be provoked. In these patients the diagnosis was arrhythmogenic cardiomyopathy associated by provocable Brugada syndrome...
June 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27906652/management-of-brugada-syndrome-2016-should-all-high-risk-patients-receive-an-icd-all-high-risk-patients-should-receive-an-implantable-cardiac-defibrillator
#3
Juan Sieira, Pedro Brugada
No abstract text is available yet for this article.
November 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27906651/management-of-brugada-syndrome-2016-should-all-high-risk-patients-receive-an-icd-alternatives-to-implantable-cardiac-defibrillator-therapy-for-brugada-syndrome
#4
Bernard Belhassen
No abstract text is available yet for this article.
November 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27894866/transcriptional-regulation-of-the-sodium-channel-gene-scn5a-by-gata4-in-human-heart
#5
Anna Tarradas, Mel Lina Pinsach-Abuin, Carlos Mackintosh, Oriol Llorà-Batlle, Alexandra Pérez-Serra, Montserrat Batlle, Félix Pérez-Villa, Thomas Zimmer, Ivan Garcia-Bassets, Ramon Brugada, Pedro Beltran-Alvarez, Sara Pagans
Aberrant expression of the sodium channel gene (SCN5A) has been proposed to disrupt cardiac action potential and cause human cardiac arrhythmias, but the mechanisms of SCN5A gene regulation and dysregulation still remain largely unexplored. To gain insight into the transcriptional regulatory networks of SCN5A, we surveyed the promoter and first intronic regions of the SCN5A gene, predicting the presence of several binding sites for GATA transcription factors (TFs). Consistent with this prediction, chromatin immunoprecipitation (ChIP) and sequential ChIP (Re-ChIP) assays show co-occupancy of cardiac GATA TFs GATA4 and GATA5 on promoter and intron 1 SCN5A regions in fresh-frozen human left ventricle samples...
November 25, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27890882/a-case-of-brugada-syndrome-which-developed-status-epilepticus
#6
Misa Matsui, Kimiko Inoue, Harutoshi Fujimura, Saburo Sakoda
A 35-year-old man showed a convulsive attack with consciousness loss and was suspected of having Brugada syndrome 6 months prior to admission to our hospital. At the initial examination, the patient showed conjugate deviation, followed by left limb convulsions and consciousness loss. He regained consciousness after 1 minute, though cardiac arrest from ventricular fibrillation was noted during an electroencephalography (EEG) examination. Sinus rhythm recovered with defibrillation, though the convulsions persisted and a Status Epilepticus developed...
November 25, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27890733/differences-in-the-onset-mode-of-ventricular-tachyarrhythmia-between-patients-with-j-wave-in-anterior-leads-versus-inferolateral-leads
#7
Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Yuko Y Inoue, Koji Miyamoto, Hideo Okamura, Satoshi Nagase, Takashi Noda, Takeshi Aiba, Satoshi Yasuda, Wataru Shimizu, Shiro Kamakura, Kengo Kusano
BACKGROUND: The pathophysiological mechanism of J wave in anterior leads (A-leads) and inferolateral leads (L-leads) remains unclear. OBJECTIVE: We investigated the onset mode and circadian distribution of ventricular tachyarrhythmia (VTA) episodes in patients with early repolarization syndrome (ERS) and Brugada syndrome (BrS). METHODS: The study enrolled 35 ERS patients and 52 type 1 BrS patients with spontaneous ventricular fibrillation who were divided into four groups: ERS(A+L) (n=15), ERS patients who had non-type 1 Brugada-pattern electrocardiogram (ECG) in any A-leads (2(nd) to 4(th) intercostal spaces) in control and/or after drug provocation tests; ERS(L) (n=20), ERS with J wave only in L-leads; BrS(A) (n=24), BrS without J wave in L-leads; and, BrS(A+L) (n=28), BrS with J wave in L-leads...
November 23, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27889554/familial-dilated-cardiomyopathy-a-multidisciplinary-entity-from-basic-screening-to-novel-circulating-biomarkers
#8
REVIEW
D de Gonzalo-Calvo, M Quezada, O Campuzano, A Perez-Serra, J Broncano, R Ayala, M Ramos, V Llorente-Cortes, S Blasco-Turrión, F J Morales, P Gonzalez, R Brugada, A Mangas, R Toro
Idiopathic dilated cardiomyopathy has become one of the most prevalent inherited cardiomyopathies over the past decades. Genetic screening of first-degree relatives has revealed that 30-50% of the cases have a familial origin. Similar to other heart diseases, familial dilated cardiomyopathy is characterized by a high genetic heterogeneity that complicates family studies. Cli'nical screening, 12-lead electrocardiogram and transthoracic echocardiogram are recommended for patients and first-degree family members...
November 8, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27885745/exaggerated-reactivity-of-parasympathetic-nerves-is-involved-in-ventricular-fibrillation-in-j-wave-syndrome
#9
Tetsuji Shinohara, Hidekazu Kondo, Toyokazu Otsubo, Akira Fukui, Kunio Yufu, Mikiko Nakagawa, Naohiko Takahashi
INTRODUCTION: Brugada syndrome (BrS) and early repolarization syndrome (ERS) are termed the J-wave syndrome. In most cases of J-wave syndrome, ventricular fibrillation (VF) often occurs around midnight or in the early morning when parasympathetic tone is augmented. OBJECTIVE: The purpose of this study was to clarify the relationship between VF and autonomic nervous activity in patients with J-wave syndrome. METHODS AND RESULTS: We enrolled 28 consecutive patients with J-wave syndrome (20 BrS and 8 ERS) in whom implantable cardioverter-defibrillators (ICDs) were implanted between January 2002 and December 2014...
November 25, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27884575/brugada-pattern-caused-by-a-flecainide-overdose
#10
Elena Tessitore, Majd Ramlawi, Olivier Tobler, Henri Sunthorn
BACKGROUND: Brugada pattern can be found on the electrocardiogram (ECG) of patients with altered mental status, usually with fever or drug intoxication. Diagnosis remains challenging, because the ECG changes are dynamic and variable. In addition, triggers are not always clearly identified. In patients with atrial fibrillation (AF), the use of class IC antidysrhythmic drugs can unmask a Brugada pattern on the ECG, especially if combined with other medications acting on sodium channels...
November 21, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27871986/second-generation-cryoballoon-ablation-without-the-use-of-real-time-recordings-a-novel-strategy-based-on-a-temperature-guided-approach-to-ablation
#11
Saverio Iacopino, Giacomo Mugnai, Ken Takarada, Gaetano Paparella, Erwin Ströker, Valentina De Regibus, Hugo Enrique Coutino-Moreno, Rajin Choudhury, Juan Pablo Abugattas de Torres, Pedro Brugada, Carlo de Asmundis, Gian-Battista Chierchia
BACKGROUND: The achievement of -40°C within 60 seconds has proven to independently predict durable PV isolation in the setting of second generation cryoballoon (CB-A; Medtronic; USA) ablation. OBJECTIVE: In the present study, we sought to evaluate a strategy based on the attainment of the specific parameter of -40°C within the first 60 seconds during cryoenergy applications in the setting of CB-A without the use of an inner lumen mapping catheter (ILMC) (Achieve; Medtronic, USA) for the visualisation of real time recordings (RTR)...
November 18, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27871569/near-miss-in-a-patient-with-undiagnosed-brugada-syndrome-a-case-report-and-literature-review
#12
Tariq Alzahrani
Brugada syndrome is a rare genetic disorder mostly affecting young subjects without any underlying heart disease. Here we are describing 1 patient presented for gastric bypass surgery who had near cardiac arrest under general anesthesia for unknown reason. Postoperative investigation of this case revealed the diagnosis of Brugada syndrome.
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27863892/pericarditis-mimicking-brugada-syndrome-a-case-report
#13
Manuel Monti, Giulia Olivi, Francesca Francavilla, Francesco Borgognoni
INTRODUCTION: Brugada syndrome (BrS) is a genetic heart disorder due to alteration of the ion channels function that causes an impaired in the cardiac conduction system. It is characterized by an abnormal electrocardiogram pattern and may be complicated by malignant ventricular arrhythmias. Pericarditis is an inflammation of the pericardium and 90% of isolated cases of acute pericarditis are idiopathic or viral. Acute pericarditis may appears with chest pain, fever, pericardial friction rub, and cardiac tamponade...
November 9, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27862715/effect-of-cardiac-resynchronization-therapy-in-patients-with-diabetes-randomized-in-echocrt
#14
REVIEW
Matthias P Nägele, Jan Steffel, Michele Robertson, Jagmeet P Singh, Andreas J Flammer, Jeroen J Bax, Jeffrey S Borer, Kenneth Dickstein, Ian Ford, John Gorcsan, Daniel Gras, Henry Krum, Peter Sogaard, Johannes Holzmeister, William T Abraham, Josep Brugada, Frank Ruschitzka
AIMS: As patients with heart failure (HF) and concomitant diabetes carry a poor prognosis, this post-hoc subgroup analysis aimed to compare the outcomes of patients with and without diabetes randomized in the Echocardiography Guided Cardiac Resynchronization Therapy (EchoCRT) study. METHODS AND RESULTS: EchoCRT randomized patients with a QRS duration <130 ms and echocardiographic evidence of left ventricular dyssynchrony to CRT turned on (CRT=ON) vs. off (CRT=OFF) following device implantation...
November 11, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27848162/characterizing-the-spectrum-of-right-ventricular-remodelling-in-response-to-chronic-training
#15
Marta Sitges, Beatriz Merino, Constatine Butakoff, Maria Sanz de la Garza, Carles Paré, Silvia Montserrat, Barbara Vidal, Manel Azqueta, Georgia Sarquella, Josep Antoni Gutierrez, Ramon Canal, Josep Brugada, Bart H Bijnens
The significance and spectrum of reduced right ventricular (RV) deformation, reported in endurance athletes, is unclear. To comprehensively analyze the cardiac performance at rest of athletes, especially focusing on integrating RV size and deformation to unravel the underlying triggers of this ventricular remodelling. Hundred professional male athletes and 50 sedentary healthy males of similar age were prospectively studied. Conventional echocardiographic parameters of all four chambers were obtained, as well as 2D echo-derived strain (2DSE) in the left (LV) and in the RV free wall with separate additional analysis of the RV basal and apical segments...
November 15, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27844191/-indications-for-implantable-loop-recorders-in-patients-with-channelopathies-and-ventricular-tachycardias
#16
Julia Köbe, Kristina Wasmer, Florian Reinke, Lars Eckardt
Implantable loop recorders (ILR) do not play a pivotal role in the current guidelines on ventricular arrhythmias except in identifying rhythm-symptom correlations if ventricular arrhythmias are assumed. Before a decision for a pure diagnostic implantable device is made, a thorough arrhythmic risk assessment is of major importance due to the potential lethal outcome of ventricular arrhythmias. Nevertheless, some clinical circumstances exist where long-term monitoring by an ILR may add significant information in electrical heart diseases, in patients with ventricular arrhythmias, or structural heart diseases and a potential risk of ventricular arrhythmias...
November 14, 2016: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/27830074/sodium-channel-blockade-unmasked-brugada-electrocardiographic-pattern-in-a-patient-with-complete-right-bundle-branch-block-and-early-repolarization-in-the-lateral-leads
#17
Shozo Konishi, Hitoshi Minamiguchi, Yuji Okuyama, Yasushi Sakata
Early repolarization syndrome (ERS) and Brugada syndrome (BrS) share many electrocardiographic and clinical features, and recently have been collectively grouped as J wave syndrome. However, the effects of sodium channel blockers on the J waves differ greatly between ERS and BrS.
November 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27825748/-sudden-death-in-the-athlete
#18
Marta Sitges, Josep Brugada
No abstract text is available yet for this article.
November 5, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27815537/pre-participation-cardiovascular-evaluation-for-athletic-participants-to-prevent-sudden-death-position-paper-from-the-ehra-and-the-eacpr-branches-of-the-esc-endorsed-by-aphrs-hrs-and-solaece
#19
Lluís Mont, Antonio Pelliccia, Sanjay Sharma, Alessandro Biffi, Mats Borjesson, Josep Brugada Terradellas, Francois Carré, Eduard Guasch, Hein Heidbuchel, André La Gerche, Rachel Lampert, William McKenna, Michail Papadakis, Silvia G Priori, Mauricio Scanavacca, Paul Thompson, Christian Sticherling, Sami Viskin, Mathew Wilson, Domenico Corrado, Gregory Yh Lip, Bulent Gorenek, Carina Blomström Lundqvist, Bela Merkely, Gerhard Hindricks, Antonio Hernández-Madrid, Deirdre Lane, Guiseppe Boriani, Calambur Narasimhan, Manlio F Marquez, David Haines, Judith Mackall, Pedro Manuel Marques-Vidal, Ugo Corra, Martin Halle, Monica Tiberi, Josef Niebauer, Massimo Piepoli
No abstract text is available yet for this article.
November 4, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27815371/pre-participation-cardiovascular-evaluation-for-athletic-participants-to-prevent-sudden-death-position-paper-from-the-ehra-and-the-eacpr-branches-of-the-esc-endorsed-by-aphrs-hrs-and-solaece
#20
Lluís Mont, Antonio Pelliccia, Sanjay Sharma, Alessandro Biffi, Mats Borjesson, Josep Brugada Terradellas, François Carré, Eduard Guasch, Hein Heidbuchel, André La Gerche, Rachel Lampert, William McKenna, Michail Papadakis, Silvia G Priori, Mauricio Scanavacca, Paul Thompson, Christian Sticherling, Sami Viskin, Mathew Wilson, Domenico Corrado, Gregory Y H Lip, Bulent Gorenek, Carina Blomström Lundqvist, Bela Merkely, Gerhard Hindricks, Antonio Hernández-Madrid, Deirdre Lane, Guiseppe Boriani, Calambur Narasimhan, Manlio F Marquez, David Haines, Judith Mackall, Pedro Manuel Marques-Vidal, Ugo Corra, Martin Halle, Monica Tiberi, Josef Niebauer, Massimo Piepoli
No abstract text is available yet for this article.
November 4, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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