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https://www.readbyqxmd.com/read/29473530/allergoids-for-allergy-treatment
#1
Jeronimo Carnes, Maria T Gallego, Raquel Moya, Victor Iraola
Background Chemically modified allergen extracts, known as allergoids, are commonly used for treating allergic patients. In general terms, the concept of allergoids implies allergen extracts with a reduction of their allergenicity maintaining their immunogenicity. Different methods to obtain allergoids have been developed in the past years, opening attractive lines of research. Objective To review the different approaches to allergoid development as well as their characterization, mechanism of action and efficacy and safety issues...
February 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29472925/understanding-the-unfolded-protein-response-in-the-pathogenesis-of-asthma
#2
REVIEW
Prabuddha S Pathinayake, Alan C-Y Hsu, David W Waters, Philip M Hansbro, Lisa G Wood, Peter A B Wark
Asthma is a heterogeneous, chronic inflammatory disease of the airways. It is a complex disease with different clinical phenotypes and results in a substantial socioeconomic burden globally. Poor understanding of pathogenic mechanisms of the disease hinders the investigation into novel therapeutics. Emerging evidence of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) has demonstrated previously unknown functions of this response in asthma development. A worsening of asthmatic condition can be brought on by stimuli such as oxidative stress, pathogenic infections, and allergen exposure...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29470975/high-throughput-screening-of-t7-phage-display-and-protein-microarrays-as-a-methodological-approach-for-the-identification-of-ige-reactive-components
#3
P San Segundo-Acosta, M Garranzo-Asensio, C Oeo-Santos, A Montero-Calle, J Quiralte, J Cuesta-Herranz, M Villalba, R Barderas
Olive pollen and yellow mustard seeds are major allergenic sources with high clinical relevance. To aid with the identification of IgE-reactive components, the development of sensitive methodological approaches is required. Here, we have combined T7 phage display and protein microarrays for the identification of allergenic peptides and mimotopes from olive pollen and mustard seeds. The identification of these allergenic sequences involved the construction and biopanning of T7 phage display libraries of mustard seeds and olive pollen using sera from allergic patients to both biological sources together with the construction of phage microarrays printed with 1536 monoclonal phages from the third/four rounds of biopanning...
February 19, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29469745/oral-involvement-of-cutaneous-t-cell-lymphoma
#4
Jason Schoenfeld, Julia Accetta
Methylisothiazolinone (MI) is commonly used as a preservative in personal care products and is a frequent cause of allergic contact dermatitis. We present a patient with allergic contact dermatitis caused by MI in hair care products and discuss this allergen to bring attention to this common cause of contact dermatitis, and to highlight its frequent use in hair care products. If allergy to MI is suspected, testing should be performed to this individual preservative, as testing solely for the combination preservative, methylisothiazolinone/methylchloroisothiazolinone (Kathon CG®), may miss many cases of MI allergy...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29468728/european-surveillance-system-on-contact-allergies-essca-polysensitization-2009-2014
#5
Daan Dittmar, Wolfgang Uter, Andrea Bauer, Anna B Fortina, Andreas J Bircher, Magdalena Czarnecka-Operacz, Aleksandra Dugonik, Peter Elsner, Rosella Gallo, Sharizan A Ghaffar, Anna Giménez-Arnau, Graham A Johnston, Beata Kręcisz, Francesca L Filon, Thomas Rustemeyer, Anna Sadowska-Przytocka, Javier Sánchez-Pérez, Axel Schnuch, Dagmar Simon, Radoslaw Spiewak, Philipp Spring, Maria T Corradin, Skaidra Valiukevičienė, Marko Vok, Elke Weisshaar, Mark Wilkinson, Marie L Schuttelaar
BACKGROUND: Polysensitization, defined as being allergic to three or more haptens from the European baseline series, is considered to reflect increased susceptibility to developing a contact allergy, and is likely to be associated with an impaired quality of life. OBJECTIVES: To evaluate the prevalences of polysensitization across Europe and to analyse factors associated with polysensitization. METHODS: Patch test data collected by the European Surveillance System on Contact Allergies (ESSCA; www...
February 22, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29467760/microrna-regulation-of-host-immune-responses-following-fungal-exposure
#6
REVIEW
Tara L Croston, Angela R Lemons, Donald H Beezhold, Brett J Green
Fungal bioaerosols are ubiquitous in the environment and human exposure can result in a variety of health effects ranging from systemic, subcutaneous, and cutaneous infections to respiratory morbidity including allergy, asthma, and hypersensitivity pneumonitis. Recent research has focused on the role of microRNAs (miRNAs) following fungal exposure and is overlooked, yet important, group of regulators capable of influencing fungal immune responses through a variety of cellular mechanisms. These small non-coding ribose nucleic acids function to regulate gene expression at the post-transcriptional level and have been shown to participate in multiple disease pathways including cancer, heart disease, apoptosis, as well as immune responses to microbial hazards and occupational allergens...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29467434/conformational-ige-epitope-mapping-of-der-p-2-and-the-evaluations-of-two-candidate-hypoallergens-for-immunotherapy
#7
Kavita Reginald, Fook Tim Chew
Epitope mapping of Der p 2, a clinically important dust-mite allergen is the first step in designing immunotherapy hypoallergen vaccine candidates. Twenty-one single alanine mutants of Der p 2 were generated and their secondary structure was analysed using circular dichroism spectra. Only one mutant, K96A resulted in a misfolded protein. All mutants were tested for serum IgE reactivity using serum from dust mite allergic individuals by immuno dot-blots. Mutations to five residues, N10, E25, K77, K96 and E102 consistently showed reduced IgE reactions compared to wild-type Der p 2, and therefore these residues constitute the major IgE epitopes of Der p 2...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29466894/a-preliminary-study-on-topical-ozonated-oil-in-the-therapeutic-management-of-atopic-dermatitis-in-murine
#8
J Lu, M Chen, L Gao, Q Cheng, Y Xiang, J Huang, K Wu, J Huang, M Li
Atopic dermatitis (AD) is an inflammatory skin disease characterized as a Th2-predominant immune response. Patients are susceptible to infection. Ozone is used for wound treatment due to its anti-infection features. However, it is unclear whether ozone can recovery AD lesions. In this study, mice were repeatedly challenged with the triplex allergens of staphylococcal enterotoxin B, ovalbumin and calcipotriol ointment on the back to develop AD lesions and were treated with ozonated oil. We found that ozonated oil significantly inhibited inflammation and healed the lesions in 7 days...
February 22, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29466753/human-t-cell-development-localization-and-function-throughout-life
#9
REVIEW
Brahma V Kumar, Thomas J Connors, Donna L Farber
Throughout life, T cells coordinate multiple aspects of adaptive immunity, including responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is studied in the context of a specific type of pathogen, antigen, or disease condition over a limited time frame, whereas in humans, T cells control multiple insults simultaneously throughout the body and maintain immune homeostasis over decades. In this review, we discuss how human T cells develop and provide essential immune protection at different life stages and highlight tissue localization and subset delineation as key determinants of the T cell functional role in immune responses...
February 20, 2018: Immunity
https://www.readbyqxmd.com/read/29465897/-effects-of-nasal-provocation-with-a-single-dose-allergen-on-the-explicit-and-implicit-memory-of-physically-active-and-inactive-patients-with-ragweed-allergy
#10
Margaréta Tokodi, Eszter Csábi, Ágnes Kiricsi, Rebeka Schultz, Andor Molnár H, László Rovó, Zsolt Bella
Background and purpose: Allergy is an endemic disease and has a considerable impact on the quality of life. This study aimed to measure the effect of active allergic rhinitis on memory functions of physically active and inactive patients with ragweed allergy. Methods: Memory functions were assessed before and after allergen exposure. Participants in both groups were provoked nasally with 30 IR/mL ragweed allergen in each nostril. Explicit memory was measured with story-recalling and implicit memory was investigated with reaction time task...
January 30, 2018: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29463838/interleukin-33-is-activated-by-allergen-and-necrosis-associated-proteolytic-activities-to-regulate-its-alarmin-activity-during-epithelial-damage
#11
Ian C Scott, Jayesh B Majithiya, Caroline Sanden, Peter Thornton, Philip N Sanders, Tom Moore, Molly Guscott, Dominic J Corkill, Jonas S Erjefält, E Suzanne Cohen
Interleukin (IL)-33 is an IL-1 family alarmin released from damaged epithelial and endothelial barriers to elicit immune responses and allergic inflammation via its receptor ST2. Serine proteases released from neutrophils, mast cells and cytotoxic lymphocytes have been proposed to process the N-terminus of IL-33 to enhance its activity. Here we report that processing of full length IL-33 can occur in mice deficient in these immune cell protease activities. We sought alternative mechanisms for the proteolytic activation of IL-33 and discovered that exogenous allergen proteases and endogenous calpains, from damaged airway epithelial cells, can process full length IL-33 and increase its alarmin activity up to ~60-fold...
February 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29461689/clinical-associations-between-allergies-and-rapid-eye-movement-sleep-disturbances
#12
Shelley R Berson, Jaclyn Klimczak, Elizabeth A Prezio, Shirley Hu, Manoj Abraham
BACKGROUND: Allergic rhinitis, an immunoglobulin E inflammatory condition including nasal congestion, obstruction, sneezing, pruritus, and fatigue symptoms, has significant impact on quality of life and impairs sleep. Sleep-disordered breathing (SDB) patients often have normal all-night apnea-hypopnea (AHI) or respiratory-disturbance (RDI) indices on polysomnography (PSG). We hypothesized that the rapid eye motion-respiratory disturbance index (REM-RDI) may be a novel predictor of allergic status...
February 20, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29461211/vertebrate-tropomyosin-as-an-allergen
#13
S Peixoto, T Monteiro, M Carvalho, M Santos, C Matos, B Bartolomé, M Labrador-Horrillo, M Quaresma
No abstract text is available yet for this article.
2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29459528/-a-validation-study-of-the-improved-product-for-measuring-japanese-cypress-pollen-specific-ige-thermo-scientific-%C3%A2-immunocap-%C3%A2-immunocap-japanese-cypress-pollen-specific-ige
#14
Syuji Yonekura, Yoshitaka Okamoto, Satoshi Nakayama
BACKGROUND: Japanese cypress pollen is a major causative allergen of seasonal allergic rhinitis in Japan. Although ImmunoCAP-specific immunoglobulin E (IgE) reagent Japanese cypress pollen has been widely used as a diagnostic aid, its sensitivity requires enhancement. This study evaluated an improved version of this reagent. METHODS: Serum samples from 61 subjects who underwent Japanese cypress pollen exposure testing in an environmental challenge chamber in Chiba University were assessed using the conventional ImmunoCAPspecific IgE Japanese cypress pollen product and the improved product...
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29457485/atopy-associated-with-positive-patch-test-and-possible-allergic-contact-dermatitis
#15
Mark G Kirchhof, Gillian C de Gannes
BACKGROUND: Atopy is a genetic predisposition to the development of allergic reactions and the increased production of immunoglobulin E (IgE) upon exposure to environmental antigens. Clinical manifestations of atopy include asthma, atopic dermatitis (AD), and allergic rhinoconjunctivitis (ARC). OBJECTIVE: To determine if cutaneous delayed hypersensitivity reactions (CDHRs) as assessed by patch testing are higher among patients with a history of atopy and with a familial predisposition to atopy...
February 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29457221/association-of-stat6-gene-variants-with-food-allergy-diagnosed-by-double-blind-placebo-controlled-food-challenges
#16
C D van Ginkel, M E Pettersson, A E J Dubois, G H Koppelman
This study describes the role of two STAT6 gene variants in food allergy using data of patients and their parents who underwent double-blind placebo-controlled food challenges (DBPCFCs). After quality control, 369 trios were analyzed including 262 children (71.0%) with food allergy. Associations were tested by family based association testing (FBAT). The A alleles of both SNPs were associated with food allergy (p=0.036 and p=0.013 for rs324015 and rs1059513, respectively). Furthermore, these A alleles were associated with peanut allergy, higher sIgE levels to both peanut and cow's milk, more severe symptoms and higher eliciting doses during peanut and cow's milk DBPCFCs (all p<0...
February 19, 2018: Allergy
https://www.readbyqxmd.com/read/29456832/interleukin-25-and-eosinophils-progenitor-cell-mobilization-in-allergic-asthma
#17
Wei Tang, Steven G Smith, Wei Du, Akash Gugilla, Juan Du, John Paul Oliveria, Karen Howie, Brittany M Salter, Gail M Gauvreau, Paul M O'Byrne, Roma Sehmi
Background: Eosinophil-lineage committed progenitor cells (EoP) migrate from the bone marrow and differentiate locally to provide an ongoing source of mature eosinophils in asthmatic inflammatory responses in the airways. Sputum levels of EoP are increased in asthmatics compared to normal controls suggesting an exaggerated eosinophilopoietic environment in the airways. Understanding what factors promote EoP traffic to the airways is important to understand the diathesis of asthma pathology...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29456677/concurrent-eosinophilia-and-igg4-related-disease-in-a-child-a-case-report-and-review-of-the-literature
#18
Can Chen, Kuang Chen, Xilian Huang, Kaile Wang, Shenxian Qian
The current study presents the case of a 9-year-old Chinese boy who presented with eosinophilia and elevated serum levels of immunoglobulin G4 (IgG4). A bone marrow puncture identified an elevated eosinophil rate of 23% (normal range, <5%), which indicated eosinophilia. However, gene analysis, fluorescent in situ hybridization and other examinations, including bone marrow aspiration, blood routine, auto-antibody tests and parasitic and allergens screening, contradicted a diagnosis of secondary or clonal eosinophilia...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456195/mast-cell-tryptase-changes-with-aspergillus-fumigatus-host-crosstalk-in-cystic-fibrosis-patients
#19
Carine Gomez, Ania Carsin, Marion Gouitaa, Martine Reynaud-Gaubert, Jean-Christophe Dubus, Jean-Louis Mège, Stéphane Ranque, Joana Vitte
Pulmonary and systemic antifungal immunity influences quality of life and survival of people with cystic fibrosis. Aspergillus fumigatus (Af) induces specific IgG and IgE. Mast cells respond to IgE, IgG and direct interactions with Af. Mast cells are the source of the protease tryptase. We aimed at evaluating serum baseline tryptase as a potential biomarker of the Af-host interaction in cystic fibrosis patients. Serum baseline tryptase, IgE and IgG directed to Af extract and Af molecular allergens were measured in 76 cystic fibrosis patients...
February 15, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29456037/evaluation-of-an-intervention-to-improve-the-management-of-allergens-in-school-food-services-in-the-city-of-barcelona
#20
M Fontcuberta-Famadas, G Serral, M J López, P Balfagón, E García-Cid, L Caballé-Gavaldà
BACKGROUND: An intervention to promote the development of an allergen control plan (ACP) and preventive measures for the management of allergens in school food services was implemented in all schools of Barcelona city over a three-year period (2013-2015) by the public health services. The present study aimed to assess changes regarding the management of food allergens in school food services in Barcelona after an intervention conducted by the public health services of the city. METHODS: School meal operators of a random sample of 117 schools were assessed before and after the intervention using a structured questionnaire...
February 15, 2018: Allergologia et Immunopathologia
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