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https://www.readbyqxmd.com/read/29046027/-frequency-of-skin-reactivity-to-food-allergens-in-allergic-patients
#1
Heriberto Camero-Martínez, Aída Inés López-García, Daniela Rivero-Yeverino, Chrystopherson Gengyny Caballero-López, Oswaldo Arana-Muñoz, Sergio Papaqui-Tapia, Isabel Cristina Rojas-Méndez, Elizabeth Vázquez-Rojas
BACKGROUND: Food allergy is deemed to have a worldwide prevalence ranging from 2 to 10 %. OBJECTIVE: To determine the frequency of skin reactivity to food allergens by age groups. METHODS: Cross-sectional, descriptive, prolective, observational study. Patients aged from 2 to 64 years with symptoms consistent with allergic disease were included. Skin prick tests were carried out with food allergens. Frequencies and percentages were estimated...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29046026/-influence-of-lifestyle-diet-and-vitamin-d-on-atopy-in-a-population-of-afro-descendant-colombian-children
#2
Luis Carlos Fang-Mercado, Juan Ricardo Urrego-Álvarez, Andrés Ernesto Merlano-Barón, Catherine Meza-Torres, Luz Hernández-Bonfante, Liliana López-Kleine, Javier Marrugo-Cano
BACKGROUND: Allergic conditions have shown an increase in the past few decades. Hygiene, changes in lifestyle, diet and vitamin D have been blamed for this increase. OBJECTIVE: To determine the role of environment, diet and vitamin D in atopic diseases in a population of Colombian Afro-descendant children. METHODS: Cross-sectional, descriptive, observational study in 200 Afro-descendant children of rural and urban areas from northern Colombia...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29046023/-determination-of-a-new-cow-s-milk-based-formula-allergenic-capacity-in-7-infants
#3
Beatriz Estella López-Marín, Benjamín Rojano, Luz Marina Carvajal-de Pabón
BACKGROUND: Cow's milk protein allergy is the main allergic problem during the first year of life, possibly owing to immune and gastrointestinal systems poor maturation. To prevent allergic reactions, the content and type of proteins in infant formulas resemble those of breast milk. We believe that reactions are due rather to the amount than to the type of protein. OBJECTIVE: To design a new formula with cow's milk that provides the infant with the main nutrients at an affordable cost and with lower risk for the development of allergies...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29045903/hpari-protein-secreted-by-a-helminth-parasite-suppresses-interleukin-33
#4
Megan Osbourn, Dinesh C Soares, Francesco Vacca, E Suzanne Cohen, Ian C Scott, William F Gregory, Danielle J Smyth, Matilda Toivakka, Andrea M Kemter, Thierry le Bihan, Martin Wear, Dennis Hoving, Kara J Filbey, James P Hewitson, Holly Henderson, Andrea Gonzàlez-Cìscar, Claire Errington, Sonja Vermeren, Anne L Astier, William A Wallace, Jürgen Schwarze, Alasdair C Ivens, Rick M Maizels, Henry J McSorley
Infection by helminth parasites is associated with amelioration of allergic reactivity, but mechanistic insights into this association are lacking. Products secreted by the mouse parasite Heligmosomoides polygyrus suppress type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway. Here, we identified H. polygyrus Alarmin Release Inhibitor (HpARI), an IL-33-suppressive 26-kDa protein, containing three predicted complement control protein (CCP) modules. In vivo, recombinant HpARI abrogated IL-33, group 2 innate lymphoid cell (ILC2) and eosinophilic responses to Alternaria allergen administration, and diminished eosinophilic responses to Nippostrongylus brasiliensis, increasing parasite burden...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29045819/disruption-of-the-epidermal-barrier-induces-regulatory-t-cells-via-il-33-in-mice
#5
Anika Bruhs, Ehrhardt Proksch, Thomas Schwarz, Agatha Schwarz
Disturbance of the epidermal barrier by UV radiation (UVR) is associated with the release of antimicrobial peptides and inflammatory cytokines for the purpose of a danger response. On the other hand, UVR causes immunosuppression via regulatory T cells (Treg) which limit the inflammatory reaction. The concurrent induction of antimicrobial peptides and Treg by UVR may represent a counter-regulatory mechanism in response to barrier disruption, preventing microbial superinfection and sensitization to contact allergens, respectively, both of which cross impaired epidermis more easily...
October 15, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29045689/sensitivity-to-house-dust-mites-allergens-with-atopic-asthma-and-its-relationship-with-cd14-c-159t-polymorphism-in-patients-of-west-bengal-india
#6
Amlan Ghosh, Shampa Dutta, Sanjoy Podder, Priti Mondal, Arghya Laha, Nimai Chandra Saha, Saibal Moitra, Goutam Kumar Saha, Richard Johnson
India is the home to around 15-20 million asthmatics, and asthma prevalence is increasing in Indian metropolitan area, including Kolkata, West Bengal. Complex interactions of genetic and environmental factors are involved in asthma. Genome-wide search for susceptible loci regulating IgE response (atopy) have identified a candidate gene CD14 which is most important in the context of allergic responses of respiratory system. This study was aimed to investigate the role of house dust and house dust mites in development of bronchial asthma and to explore the possible association of candidate gene CD14 with disease manifestation among Kolkata patient population...
October 17, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29045024/in-vivo-characterizations-of-the-immune-properties-of-sericin-an-ancient-material-with-emerging-value-in-biomedical-applications
#7
Zhanying Jiao, Yu Song, Yang Jin, Cheng Zhang, Dong Peng, Zhenzhen Chen, Panpan Chang, Subhas C Kundu, Guobin Wang, Zheng Wang, Lin Wang
The biosafety of sericin remains controversial. The misunderstanding regarding sericin causing adverse biological responses have been clarified by extensively reviewing relevant literatures and experimentally demonstrating that sericin exhibits mild inflammatory responses, negligible allergenicity, and low immunogenicity in vivo. This study supports that sericin is biosafe as a natural biomaterial.
October 17, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29044554/contact-dermatitis-caused-by-a-new-rubber-compound-detected-in-canvas-shoes
#8
Eva Hulstaert, Ola Bergendorff, Christina Persson, An Goossens, Liesbeth Gilissen, Malin Engfeldt, Magnus Bruze, Marie L Schuttelaar, Joost M Meijer, Hilde Lapeere
BACKGROUND: In 2015 and 2016, female patients in Flanders consulted a dermatologist because they developed skin lesions after wearing a specific brand of canvas shoes. OBJECTIVES: To identify the culprit allergen in the shoes. METHODS: Eighteen young females aged 14-22 years presented with itching and erythematous to purple-coloured eczematous lesions on both feet. They were patch tested by 10 dermatologists with the European baseline series...
October 17, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29043591/alternaria-alternata-fr-keissl-with-mutation-g143a-in-the-cyt-b-gene-is-the-source-of-a-difficult-to-control-allergen
#9
Adrian Duba, Klaudia Goriewa, Urszula Wachowska, Marian Wiwart
The saprotrophic fungus Alternaria alternata is widespread in the agro-environment and produces more than ten allergenic proteins, mostly protein Alt a 1. The frequency of the Alt a 1 gene was analyzed in a group of A. alternata isolates from winter wheat kernels obtained in Poland, and the effectiveness of various fungicides targeting the pathogen was evaluated. The Alt a 1 gene was identified in four of the seven tested isolates. A. alternata colonized 35.67% kernels on average, but its frequency increased in stored grain where the presence of epiphytes was noted on 23...
October 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29043011/debates-in-allergy-medicine-allergy-skin-testing-cannot-be-replaced-by-molecular-diagnosis-in-the-near-future
#10
Désirée Larenas-Linnemann, Jorge A Luna-Pech, Ralph Mösges
Percutaneous skin prick tests (SPT) have been considered the preferred method for confirming IgE-mediated sensitization. This reliable and minimally invasive technique correlates with in vivo challenges, has good reproducibility, is easily quantified, and allows analyzing multiple allergens simultaneously. Potent extracts and a proficient tester improve its accuracy. Molecular-based allergy diagnostics (MA-Dx) quantifies allergenic components obtained either from purification of natural sources or recombinant technology to identify the patient's reactivity to those specific allergenic protein components...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/29042229/-allergen-of-the-year-alkyl-glucoside-is-an-ingredient-in-top-selling-sunscreens-and-facial-moisturizers
#11
Emily Boozalis, Shivani Patel
No abstract text is available yet for this article.
October 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29040259/introduction-of-various-allergenic-foods-during-infancy-reduces-risk-of-ige-sensitization-at-12-months-of-age-a-birth-cohort-study
#12
Man-Chin Hua, Tsung-Chieh Yao, Chien-Chang Chen, Ming-Han Tsai, Sui-Ling Liao, Shen-Hao Lai, Chih-Yung Chiu, Kuan-Wen Su, Kuo-Wei Yeh, Jing-Long Huang
BackgroundIn this study, we aimed to determine whether introducing various allergenic foods during infancy is associated with IgE sensitization at 12 months of age.MethodsDetailed information on feeding practices regarding six possible allergenic foods (fruits, egg white, egg yolk, fish, shellfish, and peanuts) was obtained by administering age-specific questionnaires to parents of infants at ages 6 and 12 months. Fecal secretory IgA (sIgA), fecal eosinophil cationic protein (ECP), and serum levels of total IgE and IgE specific to 20 foods, and IgE specific to 20 inhalant allergens were also quantified at 12 months of age...
November 2017: Pediatric Research
https://www.readbyqxmd.com/read/29038898/molecular-and-immunological-characterisation-of-tropomyosin-from-anisakis-pegreffii
#13
Abdouslam Asnoussi, Ibukun E Aibinu, Robin B Gasser, Andreas L Lopata, Peter M Smooker
Tropomyosin (TM) is a major allergen in shellfish, known to cross-react with mite, cockroach and/or some roundworm (nematode) TM. In this study, we aimed to express and purify TM from the parasitic nematode Anisakis pegreffii and also to characterise its cross-reactivity with TM from shellfish. A. pegreffii was isolated from the flathead tiger fish (Neoplatycephalus richardsoni) and characterised using single-strand conformation polymorphism (SSCP)-based sequencing of the first and second internal transcribed spacers (ITS-1 and ITS-2) of nuclear ribosomal DNA...
October 16, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29038643/current-diagnostic-and-treatment-strategies-for-eosinophilic-esophagitis
#14
Anna M Lipowska, Robert T Kavitt
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus diagnosed by the presence of esophageal symptoms accompanied by an esophageal eosinophilic infiltrate. EoE has an increasing worldwide prevalence and can be a cause of dysphagia and food impactions. There is an important role for the use of proton pump inhibitors in the diagnostic pathway of EoE. Treatment paradigms for EoE aim to minimize esophageal inflammation and improve symptom control. Dietary therapy targets dietary allergens and encompasses the elemental diet, the allergy testing-directed elimination diet, and the empiric elimination diet...
September 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29038166/why-and-how-to-step-down-chronic-asthma-drugs
#15
REVIEW
Michael R Gionfriddo, John B Hagan, Matthew A Rank
Asthma is a common chronic airways disease. The goal of asthma management is to control symptoms while minimizing the side effects of treatment. Following a period of stable asthma, clinicians should consider stepping down treatment. This approach is recommended by current guidelines. Step-down has been studied for several types of asthma drug regimens, and certain approaches may have lower risk than others. Systematic reviews of multiple trials support the following specific step-down approaches: optimizing inhaled corticosteroid dosing when stepping down oral corticosteroid, reducing inhaled corticosteroid from a higher dose, lowering inhaled corticosteroid-long acting bronchodilator (ICS-LABA) dose while adding ICS-LABA on-demand, adding leukotriene receptor antagonist (LTRA) while lowering inhaled corticosteroid dose, and using allergen immunotherapy when reducing inhaled corticosteroid from a higher dose...
October 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29038008/fibrinogen-cleavage-products-and-tlr4-promote-the-generation-of-programmed-cell-death-1-ligand-2-pd-l2-dendritic-cells-in-allergic-asthma
#16
Minkyoung Cho, Jeong-Eun Lee, Hoyong Lim, Hyun-Woo Shin, Roza Khalmuratova, Garam Choi, Hyuk Soon Kim, Wahn Soo Choi, Young-Jun Park, Inbo Shim, Byung-Seok Kim, Chang-Yuil Kang, Jae-Ouk Kim, Shinya Tanaka, Masato Kubo, Yeonseok Chung
BACKGROUND: Inhaled protease allergens preferentially trigger Th2-mediated inflammation in allergic asthma. The role of dendritic cells (DCs) on the induction of Th2 cell responses in allergic asthma has been well documented; however, the mechanism by which protease allergens induce Th2-favorable DCs in the airway remains unclear. OBJECTIVE: We sought to determine a subset of DCs responsible for Th2 cell responses in allergic asthma and the mechanism by which protease allergens induce the DC subset in the airway...
October 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29037873/cross-linked-ovalbumin-catalyzed-by-polyphenol-oxidase-preparation-structure-and-potential-allergenicity
#17
Ke Liu, Shuguang Chen, Hongbing Chen, Ping Tong, Jinyan Gao
Ovalbumin (OVA) is described as one of the major allergens in hen's egg, and it is the most abundant protein in egg white. Enzyme-mediated covalent cross-linking of food proteins, can influence their structure and allergenicity. The aim of this study was to investigate the potential of polyphenol oxidase from Agaricus bisporus to cross-link OVA (CL-OVA) in the presence or absence of caffeic acid, followed by characterizing the structure and allergenicity of CL-OVA. A single-factor experiment was designed to assess the optimum conditions for cross-linking of OVA by sodium dodecyl sulfate-polyacrylamide gel electrophoresis...
October 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29037302/feno-levels-increase-with-degree-of-sensitisation-in-apprentices-at-risk-of-occupational-asthma
#18
P Wild, H Mével, E Penven, D Zmirou-Navier, A Barbaud, A Bohadana, C Paris
BACKGROUND: Atopy has emerged as a major determinant of airway inflammation. OBJECTIVE: To examine whether early markers of occupational asthma increase with degree of sensitisation. METHOD: This study was a prospective follow-up study of apprentices in baking, pastry-cooking and hairdressing during their 2-year apprenticeship. Four visits were conducted to administer a standardised questionnaire, a methacholine challenge test to assess bronchial hyperresponsiveness (BHR) and to measure fractional exhaled nitric oxide (FeNO)...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29037263/long-term-effects-of-allergen-specific-subcutaneous-immunotherapy-for-house-dust-mite-induced-allergic-rhinitis
#19
E Sahin, D Dizdar, M E Dinc, A A Cirik
BACKGROUND: Allergic rhinitis is strongly associated with the presence of house dust mites. This study investigated the long-term effects of allergen-specific immunotherapy. Allergen-specific immunotherapy was applied over three years. The study was based on a 10-year follow up of patients with allergic rhinitis. METHODS: The study was conducted between 2001 and 2015. Skin prick test results and symptom scores were evaluated before (26 patients) and after 3 years (20 patients) of allergen-specific immunotherapy (using data from a previously published study), and 10 years after allergen-specific immunotherapy had ended (20 of 26 patients)...
October 17, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29035299/two-distinct-conformations-in-bet-v-2-determine-its-proteolytic-resistance-to-cathepsin-s
#20
Wai Tuck Soh, Peter Briza, Elfriede Dall, Claudia Asam, Mario Schubert, Sara Huber, Lorenz Aglas, Barbara Bohle, Fatima Ferreira, Hans Brandstetter
Birch pollen allergy affects more than 20% of the European allergic population. On a molecular level, birch pollen allergy can be linked to the two dominant allergens Bet v 1 and Bet v 2. Bet v 2 belongs to the profilin family, which is abundant in the plant kingdom. Importantly, the homologous plant profilins have a conserved cysteine motif with a currently unknown functional relevance. In particular, it is unknown whether the motif is relevant for disulfide formation and to what extent it would affect the profilins' structural, functional and immunological properties...
October 16, 2017: International Journal of Molecular Sciences
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