keyword
https://read.qxmd.com/read/38535325/the-effect-of-dietary-protein-hydrolysate-from-black-soldier-fly-larvae-and-schizochytrium-on-palatability-nutrient-metabolites-and-health-status-in-beagle-dogs
#1
JOURNAL ARTICLE
Yu Wei, Lingfeng Xue, Deying Ma, Yuxiao Weng, Mingkang Liu, Luyang Li, Ziyi Dai, Ziyun Zhao, Haifeng Wang, Xiao Xu
Protein hydrolysate from black soldier fly larvae (BSFP) has garnered great attention with its lower allergenicity, high amount of essential amino acids, and small bioactive peptides. Schizochytrium is a promising alternative source of n-3 FUFA because it has enriched docosahexaenoic acid (DHA, C22: 6). The aim of this study was to assess palatability, the presence of diarrhea, plasma biochemistry panels, anti-oxidative and anti-inflammatory effects, and immune function in beagle dogs when supplementing a mixture of protein hydrolysate from black soldier fly larvae and schizochytrium (BSFPs) into their diets...
March 14, 2024: Metabolites
https://read.qxmd.com/read/38534844/sporopollenin-capsules-as-biomimetic-templates-for-the-synthesis-of-hydroxyapatite-and-%C3%AE-tcp
#2
JOURNAL ARTICLE
Arianna De Mori, Daniel Quizon, Hannah Dalton, Berzah Yavuzyegit, Guido Cerri, Milan Antonijevic, Marta Roldo
Pollen grains, with their resilient sporopollenin exine and defined morphologies, have been explored as bio-templates for the synthesis of calcium phosphate minerals, particularly hydroxyapatite (HAp) and β-tricalcium phosphate (TCP). Various pollen morphologies from different plant species (black alder, dandelion, lamb's quarters, ragweed, and stargazer lily) were evaluated. Pollen grains underwent acid washing to remove allergenic material and facilitate subsequent calcification. Ragweed and lamb's quarter pollen grains were chosen as templates for calcium phosphate salts deposition due to their distinct morphologies...
March 4, 2024: Biomimetics
https://read.qxmd.com/read/38534759/the-beneficial-role-of-lactobacillus-paracasei-subsp-paracasei-ntu-101-in-the-prevention-of-atopic-dermatitis
#3
JOURNAL ARTICLE
Chin-Feng Liu, Tsung-Wei Shih, Chun-Lin Lee, Tzu-Ming Pan
Atopic dermatitis (AD) is a recurrent allergic disease characterized by symptoms such as itching, redness, swelling, dryness, scaling skin, inflammation, and tissue damage. The underlying pathogenesis of AD remains unclear. Steroid drugs are commonly used in the clinical treatment of AD; however, their long-term use may lead to associated complications. Numerous studies have indicated that probiotics could modulate the immune system, enhance immune function, or suppress excessive immune responses. In this study, Lactobacillus paracasei subsp...
March 9, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534417/ccl28-a-promising-biomarker-for-assessing-salivary-gland-functionality-and-maintaining-healthy-oral-environments
#4
JOURNAL ARTICLE
Yuichiro Kaibori, Saho Tamoto, Sayoko Okuda, Kazuhiko Matsuo, Takashi Nakayama, Daisuke Nagakubo
The oral cavity serves as the primary path through which substances from the outside world enter our body. Therefore, it functions as a critical component of host defense. Saliva is essential for maintaining a stable oral environment by catching harmful agents, including pathogens, allergens, and chemicals, in the air or food. CCL28, highly expressed in mucosal tissues, such as the colon and salivary glands, is a chemokine that attracts CCR10/CCR3 expressing cells. However, the role of CCL28 in salivary gland formation remains unclear...
February 27, 2024: Biology
https://read.qxmd.com/read/38533918/effects-of-increasing-sensitizing-doses-of-ovalbumin-on-airway-hyperresponsiveness-in-asthmatic-mice
#5
JOURNAL ARTICLE
Yan-Jiao Chen, Yu Yuan, Lu Peng, Xin-Yi Dong, Yu-Dong Xu, Yu Wang, Yong-Qing Yang
BACKGROUND: The dosage of ovalbumin (OVA) during the sensitization stage is considered a crucial factor in the development of airway hyperresponsiveness (AHR). However, the inconsistent dosages of sensitizing OVA used in current studies and the lack of research on their impact on AHR are notable limitations. METHODS: We examined the impact of increasing sensitizing doses of OVA in a murine asthma model, which entailed initial sensitization with OVA followed by repeated exposure to OVA aerosols...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38533360/clinical-relevance-of-cluster-analysis-in-phenotyping-allergic-rhinitis-in-the-paediatric-population-of-the-kuyavian-pomeranian-voivodeship-poland
#6
JOURNAL ARTICLE
Agnieszka Kowalczyk, Aneta Krogulska
INTRODUCTION: Allergic rhinitis (AR) is the most common allergic disease in the world, and additionally, its prevalence is successively increasing. Children with AR constitute a heterogeneous group of patients differing both in the course of AR and in the frequency of asthma coexistence. It is possible to identify children with AR at risk of a more severe course of the disease by analysing the potential family, environmental and clinical factors related to the development of the disease; the findings will help identify patients with a higher risk of developing asthma in the future, and who will benefit the most from early allergen-specific immunotherapy...
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38533354/history-of-pollutant-adjuvants-in-respiratory-allergy
#7
REVIEW
Dennis Shusterman
Combined exposures to allergens and air pollutants emerged as a topic of concern in scientific circles by the 1980's, when it became clear that parallel increases in respiratory allergies and traffic-related air pollution had been occurring during the 20th century. Although historically there has been a tendency to treat exposure-related symptoms as either allergic or toxicologic in nature, cross-interactions have since been established between the two modalities. For example, exposure to selected air pollutants in concert with a given allergen can increase the likelihood that an individual will become sensitized to that allergen, strongly suggesting that the pollutant acted as an adjuvant ...
2024: Front Allergy
https://read.qxmd.com/read/38532775/discontinuous-translocation-of-a-luciferase-protein-beyond-graft-junction-in-tobacco
#8
JOURNAL ARTICLE
Taira Miyahara, Hitomi Ohkubo, Yukiko Umeyama, Taichi Oguchi, Takumi Ogawa, Daisaku Ohta, Tomofumi Mochizuki, Hiroaki Kodama
Transgrafting, a grafting technique that uses both genetically modified (GM) and non-GM plants, is a novel plant breeding technology that can be used to improve the efficiency of crop cultivation without introducing foreign genes into the edible parts of non-GM plants. This technique can facilitate the acquisition of disease resistance and/or increased yield. However, the translocation of low-molecular-weight compounds, ribonucleic acid (RNA), and proteins through graft junctions raises a potential safety risk for food crops...
March 2024: Food safety
https://read.qxmd.com/read/38532772/discontinuous-translocation-of-a-luciferase-protein-beyond-graft-junction-in-tobacco
#9
JOURNAL ARTICLE
Taira Miyahara, Hitomi Ohkubo, Yukiko Umeyama, Taichi Oguchi, Takumi Ogawa, Daisaku Ohta, Tomofumi Mochizuki, Hiroaki Kodama
Transgrafting, a grafting technique that uses both genetically modified (GM) and non-GM plants, is a novel plant breeding technology that can be used to improve the efficiency of crop cultivation without introducing foreign genes into the edible parts of non-GM plants. This technique can facilitate the acquisition of disease resistance and/or increased yield. However, the translocation of low-molecular-weight compounds, ribonucleic acid (RNA), and proteins through graft junctions raises a potential safety risk for food crops...
March 2024: Food safety
https://read.qxmd.com/read/38531465/il-6-mediates-olfactory-dysfunction-in-a-mouse-model-of-allergic-rhinitis
#10
JOURNAL ARTICLE
Xiao-Yu Song, Qi Sun, Shi-Zhuang Wei, Han-Rui Wang, Yao Wang, Wen-Bin Zhang, Chao Ren, Xi-Cheng Song, Ya-Kui Mou
BACKGROUND: Immune-inflammatory response is a key element in the occurrence and development of olfactory dysfunction (OD) in patients with allergic rhinitis (AR). As one of the core factors in immune-inflammatory responses, interleukin (IL)-6 is closely related to the pathogenesis of allergic diseases. It may also play an important role in OD induced by diseases, such as Sjögren's syndrome and coronavirus disease 2019. However, there is no study has reported its role in OD in AR...
March 24, 2024: Brain Research
https://read.qxmd.com/read/38531299/recent-advance-in-sesame-allergens-influence-of-food-processing-and-their-detection-methods
#11
REVIEW
Jianhua Zeng, Feifei Ma, Ligong Zhai, Chuanlai Du, Jinlong Zhao, Zhenxing Li, Jin Wang
Sesame (Sesamum indicum L.) is a valuable oilseed crop with numerous nutritional benefits containing a diverse range of bioactive compounds. However, sesame is also considered an allergenic food that triggers various mild to severe adverse reactions (e.g., anaphylaxis). Strict dietary avoidance of sesame components is the best option to protect the sensitized consumers. Sesame or sesame-derived foods are always consumed after certain food processing operations, which would cause a considerable impact on the structure of sesame proteins, changing their sensitization capacity and detectability...
March 21, 2024: Food Chemistry
https://read.qxmd.com/read/38530645/determining-the-impact-of-genotype-%C3%A3-environment-on-oat-protein-isolate-composition-using-hplc-and-lc-ms-techniques
#12
JOURNAL ARTICLE
Roshema Mel, Christof Rampitsch, Francis Zvomuya, Kirby T Nilsen, Aaron D Beattie, Maneka Malalgoda
The effect of genotype and environment on oat protein composition was analyzed through size exclusion-high-performance liquid chromatography (SE-HPLC) and liquid chromatography-mass spectrometry (LC-MS) to characterize oat protein isolate (OPI) extracted from three genotypes grown at three locations in the Canadian Prairies. SE-HPLC identified four fractions in OPI, including polymeric globulins, avenins, glutelins, and albumins, and smaller proteins. The protein composition was dependent on the environment, rather than the genotype...
March 26, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38530075/effectiveness-of-allergen-immunotherapy-with-house-dust-mite-extract-for-pediatric-bronchial-asthma
#13
JOURNAL ARTICLE
Masaaki Hamada, Keigo Saeki, Ichiro Tanaka
Aim: We compared the effectiveness of rush subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) using standardized house dust mite (HDM) extract for pediatric bronchial asthma (BA). Methods: We followed the pediatric BA treatment score during 3 years of treatment. We assessed the median time to no longer requiring long-term control pharmacotherapy (LTCP) for BA (LTCP-free). We compared the outcomes after adjustment for confounding factors and propensity score matching. Results: Patients in the HDM SCIT group achieved the LTCP-free status significantly earlier than those in the HDM SLIT group after adjustment for confounding factors and propensity score matching...
March 26, 2024: Immunotherapy
https://read.qxmd.com/read/38529801/precision-allergy-molecular-diagnosis-applications-in-food-allergy
#14
JOURNAL ARTICLE
Sakura Sato, Motohiro Ebisawa
PURPOSE OF THE REVIEW: Precision medicine has become important in the diagnosis and management of food allergies. This review summarizes the latest information regarding molecular allergology, an essential component of food allergy managements. RECENT FINDINGS: Component-resolved diagnostics (CRD) can be used to investigate sensitization to allergens based on symptoms and to reveal co-sensitization and/or cross-sensitization in patients with allergies. The following allergen components are known to be associated with symptoms: ovomucoid from eggs, omega-5 gliadin from wheat, and many storage proteins (Gly m 8 from soy, Ara h 2 from peanut, Cor a 14 from hazelnut, Ana o 3 from cashew nut, Jug r 1 from walnut, and Ses i 1 from sesame)...
March 27, 2024: Current Opinion in Allergy and Clinical Immunology
https://read.qxmd.com/read/38529288/comprehensive-analysis-of-lung-macrophages-and-dendritic-cells-in-two-murine-models-of-allergic-airway-inflammation-reveals-model-and-subset-specific-accumulation-and-phenotypic-alterations
#15
JOURNAL ARTICLE
Belinda Camp, Ilka Jorde, Franka Sittel, Alexander Pausder, Andreas Jeron, Dunja Bruder, Jens Schreiber, Sabine Stegemann-Koniszewski
INTRODUCTION: Allergic asthma has been mainly attributed to T helper type 2 (Th2) and proinflammatory responses but many cellular processes remain elusive. There is increasing evidence for distinct roles for macrophage and dendritic cell (DC) subsets in allergic airway inflammation (AAI). At the same time, there are various mouse models for allergic asthma that have been of utmost importance in identifying key inflammatory pathways in AAI but that differ in the allergen and/or route of sensitization...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38528385/predicting-the-outcome-of-pediatric-oral-food-challenges-for-determining-tolerance-development
#16
JOURNAL ARTICLE
Hamin Kim, Kyunguk Jeong, Mireu Park, Yun Young Roh, Jae Hwa Jung, Soo Yeon Kim, Jong Deok Kim, Min Jung Kim, Yoon Hee Kim, Myung Hyun Sohn, Sooyoung Lee, Kyung Won Kim
PURPOSE: Despite the risk of anaphylaxis, oral food challenges (OFCs) are performed clinically for various indications, particularly to confirm tolerance development. This study aimed to assess OFCs by relevant indications and build an outcome prediction model to help determine when to perform OFCs in children who are likely to have developed immune tolerance. METHODS: In total, 432 pediatric OFCs were retrospectively analyzed according to indications. Clinical characteristics, serum total immunoglobulin (Ig) E, blood eosinophils, and specific IgE and IgG4 levels for food allergens were noted and compared...
March 2024: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/38527464/styrene-epoxide-unusual-allergen-in-clinical-practice
#17
Daniela Calderón, Oscar Navea, Catalina Silva, Edinson Lopez, Roberto Valdés
No abstract text is available yet for this article.
March 25, 2024: Contact Dermatitis
https://read.qxmd.com/read/38527454/emerging-and-novel-elicitors-of-anaphylaxis-collegium-internationale-allergologicum-update-2024
#18
REVIEW
Regina Treudler
BACKGROUND: Anaphylaxis represents the most severe end of the spectrum of allergic reactions. Frequent elicitors of anaphylaxis are insects, foods, and drugs. This paper summarizes recent development with regard to emerging and novel elicitors of anaphylaxis. SUMMARY: Food allergens on the rise include pulses (like pea, chickpea), seeds (hemp, chia), nuts (cashew), pseudograins (buckwheat, quinoa), fruits, and microalgae. Novel foods are foods that were not consumed to any significant extent in the European Union before May 1997, which includes four edible insects (mealworm, migratory locust, house cricket, and buffalo worm)...
March 25, 2024: International Archives of Allergy and Immunology
https://read.qxmd.com/read/38527445/prevention-of-anaphylaxis-episodes-in-idiopathic-anaphylaxis-by-omalizumab
#19
JOURNAL ARTICLE
Mitja Košnik, Lea Zugan, Matija Rijavec
INTRODUCTION: In 15-35 percent of patients with anaphylaxis, the triggering allergen cannot be found; therefore, a diagnosis of idiopathic anaphylaxis (IA) is made. We report on the outcomes in patients with IA treated with omalizumab. METHODS: We included consequent omalizumab-treated IA adult patients treated with omalizumab 300 mg every 4 weeks. RESULTS: Out of 7 patients, 6 were female, median age 40 years with the frequency of anaphylaxis episodes from 3 in 2 years to 5 in 4 months...
March 25, 2024: International Archives of Allergy and Immunology
https://read.qxmd.com/read/38527402/up-regulation-of-hsp90%C3%AE-in-hdm-induced-asthma-causes-pyroptosis-of-airway-epithelial-cells-by-activating-the-cgas-sting-er-stress-pathway
#20
JOURNAL ARTICLE
Haohua Huang, Yujie Qiao, Lanhe Chu, Cuiping Ye, Lishan Lin, Hua Liao, Xiaojing Meng, Fei Zou, Haijin Zhao, Mengchen Zou, Shaoxi Cai, Hangming Dong
Heat Shock protein 90 α (HSP90α), an main subtype of chaperone protein HSP90, involves important biological functions such as DNA damage repair, protein modification, innate immunity. However, the potential role of HSP90α in asthma occurrence and development is still unclear. This study aimed to elucidate the underlying mechanism of HSP90α in asthma by focusing on the cGAS-STING-Endoplasmic Reticulum stress pathway in inflammatory airway epithelial cell death (i.e., pyroptosis; inflammatory cell death)...
March 24, 2024: International Immunopharmacology
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