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https://www.readbyqxmd.com/read/27904584/effectiveness-and-relevant-factors-of-platelet-rich-plasma-treatment-in-managing-plantar-fasciitis-a-systematic-review
#1
REVIEW
Seet Khing Chiew, Thamil Selvee Ramasamy, Farahnaz Amini
BACKGROUND: Plantar fasciitis (PF) is a common foot complaint, affects both active sportsmen and physically inactive middle age group. It is believed that PF results from degenerative changes rather than inflammation. Platelet-rich plasma (PRP) therapy has been introduced as an alternative therapy for PF. This study is aimed to systematically review to the effectiveness and relevant factors of PRP treatment in managing PF. MATERIALS AND METHODS: A search was conducted in electronic databases, including PubMed, Scopus, and Google Scholar using different keywords...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903453/repair-of-8-oxo-7-8-dihydroguanine-in-prokaryotic-and-eukaryotic-cells-properties-and-biological-roles-of-the-fpg-and-ogg1-dna-n-glycosylases
#2
Serge Boiteux, Franck Coste, Bertrand Castaing
Oxidatively damaged DNA results from the attack of sugar and base moieties by reactive oxygen species (ROS), which are formed as byproducts of normal cell metabolism and during exposure to endogenous or exogenous chemical or physical agents. Guanine, having the lowest redox potential, is the DNA base the most susceptible to oxidation, yielding products such as 8-oxo-7,8-dihydroguanine (8-oxoG) and 2-6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG). In DNA, 8-oxoG was shown to be mutagenic yielding GC to TA transversions upon incorporation of dAMP opposite this lesion by replicative DNA polymerases...
November 26, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27901355/folic-acid-conjugated-and-ag-carrying-organoclay-nanoparticles-and-their-response-to-l929-fibroblast-and-dld-1-cancer-cells
#3
Zakir M O Rzayev, Sevda Khalilova, Kouroush Salimi
This work presents the synthesis and characterization of intercalated nanocomposites (NCs) from dispersed water solution blends of octadecyl amine-montmorillonite (ODA-MMT) (NC-0), folic acid (FA) conjugated ODA-MMT (NC-1) and Ag-MMT clay as a stable silver carrying agent (NC-2). The composition, chemical/physical and morphology of NCs with in situ intercalating nanostructures were investigated. Effect of organoclay, FA and Ag-MMT on L929 fibroblast (control), human colon carcinoma (DLD-1) cell lines, and the cytotoxicity, apoptosis and necrosis degree were estimated via WST-1/hemocytometric, double staining (as a ribonuclease A enzyme based method) and fluorescence microscopy methods in dose-dependent manner...
November 30, 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27898016/recent-advances-on-inorganic-nanoparticle-based-cancer-therapeutic-agents
#4
REVIEW
Fenglin Wang, Chengyao Li, Jing Cheng, Zhiqin Yuan
Inorganic nanoparticles have been widely investigated as therapeutic agents for cancer treatments in biomedical fields due to their unique physical/chemical properties, versatile synthetic strategies, easy surface functionalization and excellent biocompatibility. This review focuses on the discussion of several types of inorganic nanoparticle-based cancer therapeutic agents, including gold nanoparticles, magnetic nanoparticles, upconversion nanoparticles and mesoporous silica nanoparticles. Several cancer therapy techniques are briefly introduced at the beginning...
November 25, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27897241/functional-involvement-of-a-mitogen-activated-protein-kinase-module-osmkk3-osmpk7-oswrk30-in-mediating-resistance-against-xanthomonas-oryzae-in-rice
#5
Siddhi Kashinath Jalmi, Alok Krishna Sinha
Mitogen-activated protein kinases (MAPKs) are highly conserved signaling modules in eukaryotes, transmitting signals from upstream receptor to downstream target by phosphorelay mechanism. Here we report involvement of a poorly characterized group C MAPK of rice namely, OsMPK7 along with its upstream MAPK kinase, OsMKK3 and downstream target, OsWRKY30 during Xanthomonas oryzae infection, a causal agent of leaf blight disease in rice. X. oryzae infection resulted in induction of OsMPK7 and OsMKK3. OsMKK3 was found to physically interact and phosphorylate OsMPK7...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895099/new-thiazacridine-agents-synthesis-physical-and-chemical-characterization-and-in-vitro-anticancer-evaluation
#6
Mbo Chagas, Ncc Cordeiro, Kmr Marques, M G Rocha Pitta, Mjbm Rêgo, McA Lima, Mgr Pitta, I R Pitta
A series of new thiazacridine agents were synthesized and evaluated as antitumor agents, in terms of not only their cytotoxicity but also their selectivity. The cytotoxicity assay confirmed that all compounds showed cytotoxic activity and selectivity. The new compound, 3-acridin-9-ylmethyl-5-(5-bromo-1H-indol-3-ylmethylene)-thiazolidine-2,4-dione (LPSF/AA29 - 7A: ), proved to be the most promising compound as it presents lower half-maximal inhibitory concentration (IC50) values (ranging from 0.25 to 68.03 µM) depending on cell lineage...
November 27, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27894987/a-novel-approach-for-dry-powder-coating-of-pellets-with-ethylcellulose-part-i-evaluation-of-film-formulation-and-process-set-up
#7
Beatrice Albertini, Serena Bertoni, Cecilia Melegari, Luisa Stella Dolci, Nadia Passerini
An innovative dry powder coating technology was developed in a high-shear granulator using ethylcellulose (E10) as polymer. Several solid plasticizers were investigated with the aim of decreasing the polymer Tg at least to the highest possible working temperature (80°C). DSC analysis of physical mixtures of E10 and plasticizers evidenced that lauric acid (LA) was the most effective plasticizer. In order to reach the target temperature a liquid plasticizer, oleic acid (OA), was introduced in the coating formulation...
November 25, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27894293/lung-bioengineering-physical-stimuli-and-stem-progenitor-cell-biology-interplay-towards-biofabricating-a-functional-organ
#8
REVIEW
Paula N Nonaka, Juan J Uriarte, Noelia Campillo, Vinicius R Oliveira, Daniel Navajas, Ramon Farré
A current approach to obtain bioengineered lungs as a future alternative for transplantation is based on seeding stem cells on decellularized lung scaffolds. A fundamental question to be solved in this approach is how to drive stem cell differentiation onto the different lung cell phenotypes. Whereas the use of soluble factors as agents to modulate the fate of stem cells was established from an early stage of the research with this type of cells, it took longer to recognize that the physical microenvironment locally sensed by stem cells (e...
November 28, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27894229/-self-reported-experience-in-patients-treated-with-hepatitis-c-direct-acting-antivirals
#9
Irene Cañamares Orbis, Javier Saez de la Fuente, Ismael Escobar Rodriguez, Concepción Esteban Alba, Ana Such Díaz, Ismael Escobar Rodríguez
BACKGROUND AND OBJECTIVE: To learn about and analyze the self-reported treatment experience of HCV patients who started treatment with direct acting antivirals agents (DAA), at a real-time, proactive and integrated into the pharmaceutical care healthcare process, using a prospective questionnaire completed by patients as clinical tool. MATERIAL AND METHODS: Observational and cross-sectional study conducted between April (start of the National Strategic Plan) and December 2015 in the Outpatient Pharmacy Service...
November 1, 2016: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/27890643/coordination-of-dna-single-strand-break-repair
#10
Rachel Abbotts, David M Wilson
The genetic material of all organisms is susceptible to modification. In some instances, these changes are programmed, such as the formation of DNA double strand breaks during meiotic recombination to generate gamete variety or class switch recombination to create antibody diversity. However, in most cases, genomic damage is potentially harmful to the health of the organism, contributing to disease and aging by promoting deleterious cellular outcomes. A proportion of DNA modifications are caused by exogenous agents, both physical (namely ultraviolet sunlight and ionizing radiation) and chemical (such as benzopyrene, alkylating agents, platinum compounds and psoralens), which can produce numerous forms of DNA damage, including a range of "simple" and helix-distorting base lesions, abasic sites, crosslinks and various types of phosphodiester strand breaks...
November 24, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27889528/tailoring-shape-and-size-of-biogenic-silver-nanoparticles-to-enhance-antimicrobial-efficacy-against-mdr-bacteria
#11
Madhuree Kumari, Shipra Pandey, Ved Prakash Giri, Arpita Bhattacharya, Richa Shukla, Aradhana Mishra, C S Nautiyal
Spherical, rectangular, penta, and hexagonal silver nanoparticles of different dimensions were biosynthesized in an eco-friendly manner by biocontrol agent, Trichoderma viride by manipulating physical parameters, pH, temperature, and reaction time. The particles were characterized by UV-vis spectroscopy; Dynamic Light Scattering (DLS), Transmission Electron Microscopy (TEM) and Fourier Transform Infra-red Spectroscopy (FTIR). Shape and size dependent antimicrobial activity of nanoparticles against human pathogens was observed...
November 23, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27886695/pathogenesis-and-management-of-sarcopenia
#12
REVIEW
Robinder J S Dhillon, Sarfaraz Hasni
Sarcopenia represents a loss of muscle strength and mass in older individuals. Sarcopenia in the elderly has now become a major focus of research and public policy debate due to its impact on morbidity, mortality, and health care expenditure. Despite its clinical importance, sarcopenia remains under-recognized and poorly managed in routine clinical practice. This is, in part, due to a lack of available diagnostic testing and uniform diagnostic criteria. The management of sarcopenia is primarily focused on physical therapy for muscle strengthening and gait training...
February 2017: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/27886520/surprise-20-month-old-infants-understand-the-emotional-consequences-of-false-beliefs
#13
Rose M Scott
Recent studies suggest that by the second year of life, infants can attribute false beliefs to agents. However, prior studies have largely focused on infants' ability to predict a mistaken agent's physical actions on objects. The present research investigated whether 20-month-old infants could also reason about belief-based emotional displays. In Experiments 1 and 2, infants viewed an agent who shook two objects: one rattled and the other was silent. Infants expected the agent to express surprise at the silent object if she had a false belief that both objects rattled, but not if she was merely ignorant about the objects' properties...
November 22, 2016: Cognition
https://www.readbyqxmd.com/read/27884774/esponsive-multifunctional-drug-delivery-nanoparticles-for-elastic-matrix-regenerative-repair
#14
Balakrishnan Sivaraman, Ganesh Swaminathan, Lee Moore, Jonathan Fox, Dhruv Seshadri, Shataakshi Dahal, Ivan Stoilov, Maciej Zborowski, Robert Mecham, Anand Ramamurthi
: Arresting or regressing growth of abdominal aortic aneurysms (AAAs), localized expansions of the abdominal aorta are contingent on inhibiting chronically overexpressed matrix metalloproteases (MMPs)-2 and -9 that disrupt elastic matrix within the aortic wall, concurrent with providing a stimulus to augmenting inherently poor auto-regeneration of these matrix structures. In a recent study we demonstrated that localized, controlled and sustained delivery of doxycycline (DOX; a tetracycline-based antibiotic) from poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs), enhances elastic matrix deposition and MMP-inhibition at a fraction of the therapeutically effective oral dose...
November 21, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27884158/rapid-visualization-of-latent-fingermarks-using-gold-seed-mediated-enhancement
#15
Chia-Hao Su, Chun-Chieh Yu, Fong-Yu Cheng
BACKGROUND: Fingermarks are one of the most important and useful forms of physical evidence in forensic investigations. However, latent fingermarks are not directly visible, but can be visualized due to the presence of other residues (such as inorganic salts, proteins, polypeptides, enzymes and human metabolites) which can be detected or recognized through various strategies. Convenient and rapid techniques are still needed to provide obvious contrast between the background and the fingermark ridges and to then visualize latent fingermark with a high degree of selectivity and sensitivity...
November 25, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27882003/risk-factors-for-deep-venous-thrombosis-of-lower-limbs-in-postoperative-neurosurgical-patients
#16
Qiang Li, Zongxue Yu, Xiao Chen, Jinjun Wang, Guixi Jiang
OBJECTIVES: To detect the risk factors for deep venous thrombosis (DVT) in patients after neurosurgery. METHODS: Three hundred and seventy-six patients treated in the department of neurosurgery of our hospital from February 2013 to November 2015 were reviewed retrospectively. The clinical data including age, gender, hospital stay, operation time, occupation type, hypertension, coronary heart disease, diabetes, smoking status, drinking status, postoperative exercises, malignant tumor, and postoperative hormone or dehydrating agent were collected...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27879108/detecting-phase-transitions-in-collective-behavior-using-manifold-s-curvature
#17
Kelum Gajamannage, Erik M Bollt
If a given behavior of a multi-agent system restricts the phase variable to an invariant manifold, then we define a phase transition as a change of physical characteristics such as speed, coordination, and structure. We define such a phase transition as splitting an underlying manifold into two sub-manifolds with distinct dimensionalities around the singularity where the phase transition physically exists. Here, we propose a method of detecting phase transitions and splitting the manifold into phase transitions free sub-manifolds...
April 1, 2017: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/27877237/near-infrared-fluorescent-nanoparticles-derived-from-hyaluronic-acid-improve-tumor-contrast-for-image-guided-surgery
#18
Tanner K Hill, Sneha S Kelkar, Nicholas E Wojtynek, Joshua J Souchek, William M Payne, Kristina Stumpf, Frank C Marini, Aaron M Mohs
Tumor tissue that remains undetected at the primary surgical site can cause tumor recurrence, repeat surgery, and treatment strategy alterations that impose a significant patient and healthcare burden. Intraoperative near infrared fluorescence (NIRF) imaging is one potential method to identify remaining tumor by visualization of NIR fluorophores that are preferentially localized to the tumor. This requires development of fluorophores that consistently identify tumor tissue in different patients and tumor types...
2016: Theranostics
https://www.readbyqxmd.com/read/27875014/a-viologen-perylenediimide-conjugate-as-an-efficient-base-sensor-with-solvochromic-property
#19
Debapratim Das, Bapan Pramanik, Julfikar Hassan Mondal, Nilotpal Singha, Sahnawaz Ahmed, Jyotirmayee Mohanty
A viologen-perylenediimide conjugate, termed as PDEV, is prepared for efficient base sensing. The conjugate is showing solvatochromic behavior as well. The base-sensitivity of viologen is purposefully coupled with the emission property of perylenediimide (PDI) in order to lower the detection limit. PDEV has shown base sensing ability in the ppb level which is at least three orders of magnitude lower than the previously reported sensors. The probe is sensitive toward solvent polarity and generates different shades of colors based on the polarity of the medium (solvent)...
November 22, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27874293/improved-stability-of-solid-dispersions-of-manidipine-with-polyethylene-glycol-4000-copovidone-blends-application-of-ternary-phase-diagram
#20
Benchawan Chamsai, Sontaya Limmatvapirat, Srisagul Sungthongjeen, Pornsak Sriamornsak
CONTEXT: Manidipine (MDP) is generally used clinically as an antihypertensive agent; however, the bioavailability of orally administered MDP is limited very low due to their very low water solubility. OBJECTIVE: The objectives of this research were, therefore, to increase the solubility of MDP by the formation of ternary solid dispersions (tSD) with polyethylene glycol 4000 (PEG4000) and copovidone and to improve their stability. METHODS: Solid ternary phase diagram was constructed to find homogeneous solid dispersion region after melting and solidifying at low temperature with different quenching substances...
November 22, 2016: Drug Development and Industrial Pharmacy
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