Amy M Berkman, Chelsea G Goodenough, Paul Durakiewicz, Carrie R Howell, Zhaoming Wang, John Easton, Heather L Mulder, Gregory T Armstrong, Melissa M Hudson, Mondira Kundu, Kirsten K Ness
PURPOSE: Childhood cancer survivors are at risk for cardiac dysfunction and impaired physical performance, though underlying cellular mechanisms are not well studied. In this cross-sectional study, we examined the association between peripheral blood mitochondrial DNA copy number (mtDNA-CN, a proxy for mitochondrial function) and markers of performance impairment and cardiac dysfunction. METHODS: Whole-genome sequencing, validated by quantitative polymerase chain reaction, was used to estimate mtDNA-CN in 1720 adult survivors of childhood cancer (48...
April 18, 2024: Journal of Cancer Survivorship: Research and Practice